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66-422: Chuckles are jelly candies coated with a light layer of sugar. They come in five flavors: lime , orange , cherry , lemon , and licorice . Each package of Chuckles contains one piece of each flavor. The candies are made with corn syrup , sugar , modified and unmodified cornstarch , and natural and artificial flavors and colors. The Chuckles brand was first produced in 1921 by Fred W. Amend. The only factory

132-457: A " Recp.t for the Scurvy" amongst other largely medicinal and herbal recipes. The recipe consisted of extracts from various plants mixed with a plentiful supply of orange juice, white wine or beer. In 1734, Leiden -based physician Johann Bachstrom published a book on scurvy in which he stated, "scurvy is solely owing to a total abstinence from fresh vegetable food, and greens; which is alone

198-468: A "swelling and obstruction of the spleen ." In 406 CE, the Chinese monk Faxian wrote that ginger was carried on Chinese ships to prevent scurvy. The knowledge that consuming foods containing vitamin C is a cure for scurvy has been repeatedly forgotten and rediscovered into the early-20th century. In the 13th century Crusaders developed scurvy. In the 1497 expedition of Vasco da Gama ,

264-430: A few others do not. Vitamin C, an antioxidant , is required to make the building blocks for collagen , carnitine , and catecholamines , and assists the intestines in the absorption of iron from foods. Diagnosis is typically based on outward appearance, X-rays , and improvement after treatment. Treatment is with vitamin C supplements taken by mouth. Improvement often begins in a few days with complete recovery in

330-425: A few weeks. Sources of vitamin C in the diet include citrus fruit and a number of vegetables, including red peppers, broccoli, and tomatoes. Cooking often decreases the residual amount of vitamin C in foods. Scurvy is rare compared to other nutritional deficiencies. It occurs more often in the developing world in association with malnutrition . Rates among refugees are reported at 5 to 45 percent. Scurvy

396-497: A handbook for apprentice surgeons aboard the company's ships. He repeated the experience of mariners that the cure for scurvy was fresh food or, if not available, oranges, lemons, limes, and tamarinds . He was, however, unable to explain the reason why, and his assertion had no impact on the prevailing opinion of the influential physicians of the age, that scurvy was a digestive complaint. Apart from ocean travel, even in Europe, until

462-564: A means of preventing scurvy. A 1609 book by Bartolomé Leonardo de Argensola recorded a number of different remedies for scurvy known at this time in the Moluccas, including a kind of wine mixed with cloves and ginger, and "certain herbs". The Dutch sailors in the area were said to cure the same disease by drinking lime juice. In 1614, John Woodall , Surgeon General of the East India Company , published The Surgion's Mate as

528-399: A mixture of balsam of Peru , garlic , myrrh , mustard seed and radish root. In A Treatise on the Scurvy (1753) Lind explained the details of his clinical trial and concluded "the results of all my experiments was, that oranges and lemons were the most effectual remedies for this distemper at sea." However, the experiment and its results occupied only a few paragraphs in a work that

594-616: A remedy that was already known in the Spanish navy. In February 1601, Captain James Lancaster , while commanding the first English East India Company fleet en route to Sumatra , landed on the northern coast of Madagascar specifically to obtain lemons and oranges for his crew to stop scurvy. Captain Lancaster conducted an experiment using four ships under his command. One ship's crew received routine doses of lemon juice while

660-479: A rich source of vitamin C , are sour, and are often used to accent the flavours of foods and beverages. They are grown year-round. Plants with fruit called "limes" have diverse genetic origins; limes do not form a monophyletic group. The term lime originated in other languages (from French lime , from Arabic līma , from Persian līmū , ' lemon ' ). The difficulty in identifying exactly which species of fruit are called lime in different parts of

726-542: Is also called kabsa or kebsa ). Key lime gives the character flavoring to the American dessert known as Key lime pie . In Australia, desert lime is used for making marmalade . Lime is an ingredient in several highball cocktails , often based on gin , such as gin and tonic , the gimlet and the Rickey . Freshly squeezed lime juice is also considered a key ingredient in margaritas , although sometimes lemon juice

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792-620: Is also found in vegetables, such as brussels sprouts , cabbage , potatoes , and spinach . Some fruits and vegetables not high in vitamin C may be pickled in lemon juice , which is high in vitamin C. Nutritional supplements which provide ascorbic acid well in excess of what is required to prevent scurvy may cause adverse health effects. Fresh meat from animals, notably internal organs, contains enough vitamin C to prevent scurvy, and even partly treat it. Scott's 1902 Antarctic expedition used fresh seal meat and increased allowance of bottled fruits, whereby complete recovery from incipient scurvy

858-591: Is invariably fatal. Diagnosis is typically based on physical signs, X-rays , and improvement after treatment. Various childhood onset disorders can mimic the clinical and X-ray picture of scurvy such as: Scurvy can be prevented by a diet that includes uncooked vitamin C-rich foods such as amla , bell peppers (sweet peppers), blackcurrants , broccoli , chili peppers , guava , kiwifruit , and parsley . Other sources rich in vitamin C are fruits such as lemons , limes , oranges , papaya , and strawberries . It

924-489: Is needed for cellular functions throughout the body, including muscle contraction . (For low ATP within the muscle cell, see also Purine nucleotide cycle .) In the synthesis of collagen , ascorbic acid is required as a cofactor for prolyl hydroxylase and lysyl hydroxylase . These two enzymes are responsible for the hydroxylation of the proline and lysine amino acids in collagen. Hydroxyproline and hydroxylysine are important for stabilizing collagen by cross-linking

990-402: Is rarely present in adults, although infants and elderly people are affected. Virtually all commercially available baby formulas contain added vitamin C, preventing infantile scurvy. Human breast milk contains sufficient vitamin C, if the mother has an adequate intake. Commercial milk is pasteurized , a heating process that destroys the natural vitamin C content of the milk. Scurvy is one of

1056-527: Is significant for nutrition, with other nutrients present in low DV amounts (table). Lime juice contains slightly less citric acid than lemon juice (about 47 g/L), nearly twice the citric acid of grapefruit juice, and about five times the amount of citric acid found in orange juice. Lime pulp and peel contain diverse phytochemicals , including polyphenols and terpenes . Contact with lime peel or lime juice followed by exposure to ultraviolet light may lead to phytophotodermatitis , which

1122-550: Is sometimes called margarita photodermatitis or lime disease (not to be confused with Lyme disease ). Bartenders handling limes and other citrus fruits while preparing cocktails may develop phytophotodermatitis. A class of organic chemical compounds called furanocoumarins are reported to cause phytophotodermatitis in humans. Limes contain numerous furanocoumarin compounds, including limettin (also called citropten ), bergapten , isopimpinellin , xanthotoxin (also called methoxsalen ), and psoralen . Bergapten appears to be

1188-464: Is substituted. It is also found in many rum cocktails such as the daiquiri , and other tropical drinks. Lime extracts and lime essential oils are frequently used in perfumes , cleaning products, and aromatherapy . Raw limes are 88% water, 10% carbohydrates and less than 1% each of fat and protein (table). Only vitamin C content at 35% of the Daily Value (DV) per 100 g serving

1254-527: Is used to make limeade , and as an ingredient (typically as sour mix ) in many cocktails . Lime pickles are an integral part of Indian cuisine , especially in South India . In Kerala , the Onam Sadhya usually includes either lemon pickle or lime pickle. Other Indian preparations of limes include sweetened lime pickle, salted pickle, and lime chutney. In cooking , lime is valued both for

1320-619: The Ferrara Candy Company . The Chuckles trademark is currently owned by Iconic IP Interests, LLC. From 1974 to 1975, Chuckles sponsored stuntman Evel Knievel . This confectionery -related article is a stub . You can help Misplaced Pages by expanding it . Lime (fruit) There are several species of citrus trees whose fruits are called limes, including the Key lime ( Citrus aurantiifolia ), Persian lime , Makrut lime , finger limes , blood limes, and desert lime . Limes are

1386-559: The Royal Navy and Merchant Navy to provide a daily " lime or lemon juice" ration of one pound to sailors to prevent scurvy. The product became nearly ubiquitous, hence the term " limey ", first for British sailors, then for English immigrants within the former British colonies (particularly America, New Zealand and South Africa), and finally, in old American slang, all British people. The plant Cochlearia officinalis , also known as "common scurvygrass", acquired its common name from

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1452-618: The citron ( Citrus medica ), the mandarin orange ( Citrus reticulata ), the pomelo ( Citrus maxima ) and in particular with many lime varieties, the micrantha ( Citrus hystrix var. micrantha). Note that the tree species known in Britain as lime trees ( Tilia sp.), called linden or basswood in other dialects of English, are broadleaf temperate plants unrelated to the citrus fruits. Most species and hybrids of citrus plants called "limes" have varying origins within tropical Southeast Asia and South Asia . They were spread throughout

1518-404: The 19th century, British sailors were issued a daily allowance of citrus, such as lemon , and later switched to lime. The use of citrus was initially a closely guarded military secret , as scurvy was a common scourge of various national navies, and the ability to remain at sea for lengthy periods without contracting the disorder was a huge benefit for the military. British sailors thus acquired

1584-540: The 20th century. For example, the Belgian Antarctic Expedition of 1897–1899 became seriously affected by scurvy when its leader, Adrien de Gerlache , initially discouraged his men from eating penguin and seal meat. In the Royal Navy's Arctic expeditions in the mid 19th century it was widely believed that scurvy was prevented by good hygiene on board ship, regular exercise, and maintaining

1650-529: The English-speaking world (and the same problem applies to synonyms in other European languages) is increased by the botanical complexity of the Citrus genus itself, to which the majority of limes belong. Species of this genus hybridise readily; only recently have genetic studies started to shed light on the structure of the genus. The majority of cultivated species are in reality hybrids, produced from

1716-504: The French explorer Jacques Cartier , while exploring the St. Lawrence River , used the local St. Lawrence Iroquoians ' knowledge to save his men who were dying of scurvy. He boiled the needles of the arbor vitae tree ( eastern white cedar ) to make a tea that was later shown to contain 50 mg of vitamin C per 100 grams. Such treatments were not available aboard ship, where the disease

1782-747: The Napoleonic Wars made the supply of Mediterranean lemons problematic, and because they were more easily obtained from Britain's Caribbean colonies and were believed to be more effective because they were more acidic. It was the acid, not the (then-unknown) Vitamin C that was believed to cure scurvy. In fact, the West Indian limes were significantly lower in Vitamin C than the previous lemons and further were not served fresh but rather as lime juice, which had been exposed to light and air, and piped through copper tubing, all of which significantly reduced

1848-503: The Vitamin C. Indeed, a 1918 animal experiment using representative samples of the Navy and Merchant Marine's lime juice showed that it had virtually no antiscorbutic power at all. The belief that scurvy was fundamentally a nutritional deficiency, best treated by consumption of fresh food, particularly fresh citrus or fresh meat, was not universal in the 19th and early 20th centuries, and thus sailors and explorers continued to have scurvy into

1914-440: The accompanying diseases of malnutrition (other such micronutrient deficiencies are beriberi and pellagra ) and thus is still widespread in areas of the world dependent on external food aid. Although rare, there are also documented cases of scurvy due to poor dietary choices by people living in industrialized nations. Vitamins are essential to the production and use of enzymes that are involved in ongoing processes throughout

1980-638: The acidity of its juice and the floral aroma of its zest . It is a common ingredient in authentic Mexican , Vietnamese and Thai dishes. Lime soup is a traditional dish from the Mexican state of Yucatan . It is also used for its pickling properties in ceviche . Some guacamole recipes call for lime juice. The use of dried limes (called black lime or limoo ) as a flavouring is typical of Persian cuisine , Iraqi cuisine , as well as in Eastern Arabian cuisine baharat (a spice mixture that

2046-416: The cause of citrus juice, therefore, had no practical impact. The medical theory was based on the assumption that scurvy was a disease of internal putrefaction brought on by faulty digestion caused by the hardships of life at sea and the naval diet. Although this basic idea was given different emphases by successive theorists, the remedies they advocated (and which the navy accepted) amounted to little more than

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2112-591: The consumption of horse meat helped the French to curb an epidemic of scurvy. The meat was cooked but was freshly obtained from young horses bought from Arabs, and was nevertheless effective. This helped to start the 19th-century tradition of horse meat consumption in France. Lauchlin Rose patented a method used to preserve citrus juice without alcohol in 1867, creating a concentrated drink known as Rose's lime juice . The Merchant Shipping Act of 1867 required all ships of

2178-541: The consumption of 'fizzy drinks' to activate the digestive system, the most extreme of which was the regular consumption of 'elixir of vitriol' – sulphuric acid taken with spirits and barley water, and laced with spices. In 1764, a new and similarly inaccurate theory on scurvy appeared. Advocated by Dr David MacBride and Sir John Pringle , Surgeon General of the Army and later President of the Royal Society, this idea

2244-516: The curative effects of citrus fruit were already observed and were confirmed by Pedro Álvares Cabral and his crew in 1507. The Portuguese planted fruit trees and vegetables on Saint Helena , a stopping point for homebound voyages from Asia, and left their sick who had scurvy and other ailments to be taken home by the next ship if they recovered. In 1500, one of the pilots of Cabral 's fleet bound for India noted that in Malindi , its king offered

2310-417: The expedition fresh supplies such as lambs, chickens, and ducks, along with lemons and oranges, due to which "some of our ill were cured of scurvy". These travel accounts did not stop further maritime tragedies caused by scurvy, first because of the lack of communication between travelers and those responsible for their health, and because fruits and vegetables could not be kept for long on ships. In 1536,

2376-526: The human body. Ascorbic acid is needed for a variety of biosynthetic pathways, by accelerating hydroxylation and amidation reactions. The early symptoms of malaise and lethargy may be due to either impaired fatty acid metabolism from lack of carnitine, and/or from lack of catecholamines which are needed for the cAMP-dependent pathway in both glycogen metabolism and fatty acid metabolism. Impairment of either fatty acid metabolism or glycogen metabolism leads to decreased ATP (energy) production. ATP

2442-443: The lack of available game to hunt at high latitudes in winter meant it was not always a viable remedy. Criticism also focused on the fact that some of the men most affected by scurvy on Naval polar expeditions had apparently been heavy drinkers, with suggestions that this predisposed them to the condition. Even cooking fresh meat did not entirely destroy its antiscorbutic properties, especially as many cooking methods failed to bring all

2508-495: The lack of fresh fruit and vegetables in the winter. There the disease was called Spring fever or Spring disease and described an often fatal condition associated with skin lesions, bleeding gums and lethargy. It was eventually identified as scurvy and the remedies already in use at sea implemented. The surgeon-in-chief of Napoleon 's army at the Siege of Alexandria (1801) , Baron Dominique-Jean Larrey , wrote in his memoirs that

2574-608: The late Middle Ages, scurvy was common in late winter, when few green vegetables, fruits and root vegetables were available. This gradually improved with the introduction from the Americas of potatoes; by 1800, scurvy was virtually unheard of in Scotland, where it had previously been endemic. In 2009, a handwritten household book authored by a Cornishwoman in 1707 was discovered in a house in Hasfield, Gloucestershire , containing

2640-457: The late stages, jaundice , generalised edema , oliguria , neuropathy , fever, convulsions, and eventual death are frequently seen. Scurvy, including subclinical scurvy, is caused by a deficiency of dietary vitamin C, since humans are unable to metabolically synthesize vitamin C. Provided the diet contains sufficient vitamin C, the lack of working L-gulonolactone oxidase (GULO) enzyme has no significance, and in modern Western societies, scurvy

2706-595: The list of the remedies he was ordered to investigate. The others were beer, Sauerkraut (a good source of vitamin C) and Lind's 'rob'. The list did not include lemons. Cook did not lose a single man to scurvy, and his report came down in favour of malt and wort, although it is now clear that the reason for the health of his crews on this and other voyages was Cook's regime of shipboard cleanliness, enforced by strict discipline, as well as frequent replenishment of fresh food and greenstuffs. Another beneficial rule implemented by Cook

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2772-561: The medical authorities in Britain remained committed to the notion that scurvy was a disease of internal 'putrefaction' and the Sick and Hurt Board, run by administrators, felt obliged to follow its advice. Within the Royal Navy, however, opinion – strengthened by first-hand experience of the use of lemon juice at the siege of Gibraltar and during Admiral Rodney's expedition to the Caribbean – had become increasingly convinced of its efficacy. This

2838-455: The morale of the crew, rather than by a diet of fresh food. Navy expeditions continued to be plagued by scurvy even while fresh (not jerked or tinned) meat was well known as a practical antiscorbutic among civilian whalers and explorers in the Arctic. In the latter half of the 19th century there was greater recognition of the value of eating fresh meat as a means of avoiding or treating scurvy, but

2904-412: The nickname " Limey " because of their use of limes. In 2022, world production of limes (combined with lemons for reporting) was 21.5 million tonnes , led by India, Mexico, and China as the major producers (table). Limes have higher contents of sugars and acids than lemons do. Lime juice may be squeezed from fresh limes, or purchased in bottles in both unsweetened and sweetened varieties. Lime juice

2970-528: The observation that it cured scurvy, and it was taken on board ships in dried bundles or distilled extracts. Its very bitter taste was usually disguised with herbs and spices; however, this did not prevent scurvygrass drinks and sandwiches from becoming a popular fad in the UK until the middle of the nineteenth century, when citrus fruits became more readily available. West Indian limes began to take over from lemons, when Spain's alliance with France against Britain in

3036-590: The other three ships did not receive any such treatment. As a result, members of the non-treated ships started to contract scurvy, with many dying as a result. It has been estimated by researchers that during the Age of Exploration (between 1500 and 1800), scurvy killed at least two million sailors . Jonathan Lamb wrote: "In 1499, Vasco da Gama lost 116 of his crew of 170; In 1520, Magellan lost 208 out of 230; ... all mainly to scurvy." In 1593, Admiral Sir Richard Hawkins advocated drinking orange and lemon juice as

3102-410: The possibilities of producing a concentrated 'rob' of lemon juice by boiling it. This process destroyed the vitamin C and was therefore unsuccessful. During the 18th century, scurvy killed more British sailors than wartime enemy action. It was mainly by scurvy that George Anson , in his celebrated voyage of 1740–1744, lost nearly two-thirds of his crew (1,300 out of 2,000) within the first 10 months of

3168-487: The primary cause of the disease", and urged the use of fresh fruit and vegetables as a cure. It was not until 1747 that James Lind formally demonstrated that scurvy could be treated by supplementing the diet with citrus fruit, in one of the first controlled clinical experiments reported in the history of medicine. As a naval surgeon on HMS Salisbury , Lind had compared several suggested scurvy cures: hard cider , vitriol , vinegar , seawater , oranges , lemons , and

3234-552: The primary furanocoumarin compound responsible for lime-induced phytophotodermatitis. Lime peel contains higher concentrations of furanocoumarins than lime pulp (by one or two orders of magnitude). Thus lime peels are considerably more phototoxic than lime pulp. Scurvy Scurvy is a disease resulting from a lack of vitamin C (ascorbic acid). Early symptoms of deficiency include weakness, fatigue, and sore arms and legs. Without treatment, decreased red blood cells , gum disease, changes to hair, and bleeding from

3300-539: The propeptides in collagen. Collagen is a primary structural protein in the human body, necessary for healthy blood vessels, muscle, skin, bone, cartilage, and other connective tissues. Defective connective tissue leads to fragile capillaries, resulting in abnormal bleeding, bruising, and internal hemorrhaging. Collagen is an important part of bone, so bone formation is also affected. Teeth loosen, bones break more easily, and once-healed breaks may recur. Defective collagen fibrillogenesis impairs wound healing. Untreated scurvy

3366-518: The skin may occur. As scurvy worsens, there can be poor wound healing, personality changes, and finally death from infection or bleeding. It takes at least a month of little to no vitamin C in the diet before symptoms occur. In modern times, scurvy occurs most commonly in people with mental disorders , unusual eating habits, alcoholism , and older people who live alone. Other risk factors include intestinal malabsorption and dialysis . While many animals produce their own vitamin C, humans and

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3432-432: The supply of the huge quantities of lemon juice required to be secured, but by 1800, the system was in place and functioning. This led to a remarkable health improvement among the sailors and consequently played a critical role in gaining the advantage in naval battles against enemies who had yet to introduce the measures. Scurvy was not only a disease of seafarers. The early colonists of Australia suffered greatly because of

3498-544: The voyage. The Royal Navy enlisted 184,899 sailors during the Seven Years' War ; 133,708 of these were "missing" or died from disease, and scurvy was the leading cause. Although throughout this period sailors and naval surgeons were increasingly convinced that citrus fruits could cure scurvy, the classically trained physicians who determined medical policy dismissed this evidence as merely anecdotal, as it did not conform to their theories of disease. Literature championing

3564-571: The world via migration and trade. The makrut lime , in particular, was one of the earliest citrus fruits introduced to other parts of the world by humans. They were spread into Micronesia and Polynesia via the Austronesian expansion (c. 3000–1500 BCE). They were also later spread into Middle East, and the Mediterranean region via the spice trade and the incense trade routes from as early as ~1200 BCE. To prevent scurvy during

3630-474: The wort, malt and elixir of vitriol which were still being issued to ships of the Royal Navy, and demanded that he be supplied with lemons, to counteract scurvy on the voyage. Members of the Sick and Hurt Board, recently augmented by two practical naval surgeons, supported the request, and the Admiralty ordered that it be done. There was, however, a last minute change of plan, and the expedition against Mauritius

3696-550: Was cancelled. On 2 May 1794, only HMS  Suffolk and two sloops under Commodore Peter Rainier sailed for the east with an outward bound convoy, but the warships were fully supplied with lemon juice and the sugar with which it had to be mixed. In March 1795, it was reported that the Suffolk had arrived in India after a four-month voyage without a trace of scurvy and with a crew that was healthier than when it set out. The effect

3762-431: Was convinced that fresh oranges and lemons were essential for preventing scurvy. Only one outbreak occurred, during a 56-day trip across the open sea. Five sailors came down with symptoms, one seriously. After three days at Guam all five were healthy again. Spain's large empire and many ports of call made it easier to acquire fresh fruit. Although towards the end of the century MacBride's theories were being challenged,

3828-745: Was described as early as the time of ancient Egypt , and historically it was a limiting factor in long-distance sea travel, often killing large numbers of people. During the Age of Sail , it was assumed that 50 percent of the sailors would die of scurvy on a major trip. Early symptoms are malaise and lethargy . After one to three months, patients develop shortness of breath and bone pain . Myalgias may occur because of reduced carnitine production. Other symptoms include skin changes with roughness, easy bruising and petechiae , gum disease , loosening of teeth, poor wound healing, and emotional changes (which may appear before any physical changes). Dry mouth and dry eyes similar to Sjögren's syndrome may occur. In

3894-450: Was his prohibition of the consumption of salt fat skimmed from the ship's copper boiling pans, then a common practice elsewhere in the Navy. In contact with air, the copper formed compounds that prevented the absorption of vitamins by the intestines. The first major long distance expedition that experienced virtually no scurvy was that of the Spanish naval officer Alessandro Malaspina , 1789–1794. Malaspina's medical officer, Pedro González,

3960-418: Was immediate. Fleet commanders clamoured also to be supplied with lemon juice, and by June the Admiralty acknowledged the groundswell of demand in the navy and agreed to a proposal from the Sick and Hurt Board that lemon juice and sugar should in future be issued as a daily ration to the crews of all warships. It took a few years before the method of distribution to all ships in the fleet had been perfected and

4026-612: Was in Danville, Illinois . Nabisco bought the Chuckles Company in 1970. A management buyout occurred in 1986, and the company was quickly acquired by Leaf . Leaf's US properties were sold to The Hershey Company in 1996 and the Chuckles trademark was licensed to Hershey. Hershey sub-licensed Chuckles to Farley's & Sathers in 2002, which later merged with Ferrara Pan in 2012 (also owned by Catterton Partners ), forming

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4092-404: Was long and complex and had little impact. Lind himself never actively promoted lemon juice as a single 'cure'. He shared medical opinion at the time that scurvy had multiple causes – notably hard work, bad water, and the consumption of salt meat in a damp atmosphere which inhibited healthful perspiration and normal excretion – and therefore required multiple solutions. Lind was also sidetracked by

4158-490: Was most common. Later, possibly inspired by this incident, several European countries experimented with preparations of various conifers, such as spruce beer , as cures for scurvy. In 1579, the Spanish friar and physician Agustin Farfán published a book Tractado breve de anathomía y chirugía, y de algunas enfermedades que más comúnmente suelen haver en esta Nueva España in which he recommended oranges and lemons for scurvy,

4224-406: Was reinforced by the writings of experts like Gilbert Blane and Thomas Trotter and by the reports of up-and-coming naval commanders. With the coming of war in 1793, the need to eliminate scurvy acquired a new urgency. But the first initiative came not from the medical establishment but from the admirals. Ordered to lead an expedition against Mauritius, Rear Admiral Gardner was uninterested in

4290-505: Was reported to have taken less than two weeks. Scurvy will improve with doses of vitamin C as low as 10 mg per day though doses of around 100 mg per day are typically recommended. Most people make a full recovery within 2 weeks. Symptoms of scurvy have been recorded in Ancient Egypt as early as 1550  BCE . In Ancient Greece , the physician Hippocrates (460–370 BC) described symptoms of scurvy, specifically

4356-463: Was that scurvy was the result of a lack of 'fixed air' in the tissues which could be prevented by drinking infusions of malt and wort whose fermentation within the body would stimulate digestion and restore the missing gases. These ideas received wide and influential backing, when James Cook set off to circumnavigate the world (1768–1771) in HM Bark ; Endeavour , malt and wort were top of

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