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91-589: Aguaruna may refer to: Aguaruna people , an ethnic group of Peru Aguaruna language , their language Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title Aguaruna . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Aguaruna&oldid=999544983 " Category : Disambiguation pages Hidden categories: Short description

182-440: A bone experiences within long bones such as the femur . As far as short bones are concerned, trabecular alignment has been studied in the vertebral pedicle . Thin formations of osteoblasts covered in endosteum create an irregular network of spaces, known as trabeculae. Within these spaces are bone marrow and hematopoietic stem cells that give rise to platelets , red blood cells and white blood cells . Trabecular marrow

273-565: A father's search for closure, "A Darkness on the River", "On the evening of January 18, 1995", just before the outbreak of the border war with neighboring Ecuador, "two 26-year-old Americans, Josh Silver and Patchen Miller, floated down the Marañón on a large balsa-wood raft they had built several days earlier. They tied off in the eddy at the downriver tail of the island. About 9:30 that night, they were shot and left for dead. Josh Silver survived and

364-456: A kind of asymmetric form and the tendency is usually to place them in a linear form along the river. Among the Awajún there is a traditional institution of mutual aid known in their language as ipáamamu , which can be seen in action primarily when they are constructing housing for young couples, clearing fields and, with less frequency, sowing yuca and peanuts . The Awajún were traditionally

455-479: A long bone are separated by a growing zone of cartilage (the epiphyseal plate ). At skeletal maturity (18 to 25 years of age), all of the cartilage is replaced by bone, fusing the diaphysis and both epiphyses together (epiphyseal closure). In the upper limbs, only the diaphyses of the long bones and scapula are ossified. The epiphyses, carpal bones, coracoid process, medial border of the scapula, and acromion are still cartilaginous. The following steps are followed in

546-509: A mineralized organic matrix. The primary inorganic component of human bone is hydroxyapatite , the dominant bone mineral , having the nominal composition of Ca 10 (PO 4 ) 6 (OH) 2 . The organic components of this matrix consist mainly of type I collagen —"organic" referring to materials produced as a result of the human body—and inorganic components, which alongside the dominant hydroxyapatite phase, include other compounds of calcium and phosphate including salts. Approximately 30% of

637-419: A more fulfilling and healthier lifestyle. Bone is constantly being created and replaced in a process known as remodeling . This ongoing turnover of bone is a process of resorption followed by replacement of bone with little change in shape. This is accomplished through osteoblasts and osteoclasts. Cells are stimulated by a variety of signals , and together referred to as a remodeling unit. Approximately 10% of

728-623: A novel bioprospecting agreement with a US-based pharmaceutical multinational, G.D. Searle & Company (then part of Monsanto ), and a group of ethnobotanists from Washington University in St. Louis . The project involved a controversy over violations of the Aguarunas' rights over their genetic and cultural resources and to an equitable share in the potential profits derived from pharmaceuticals based on their traditional knowledge of medicinal plants. The US National Institutes of Health froze funding to

819-457: A number of anatomical terms to describe the appearance, shape and function of bones. Other anatomical terms are also used to describe the location of bones . Like other anatomical terms, many of these derive from Latin and Greek . Some anatomists still use Latin to refer to bones. The term "osseous", and the prefix "osteo-", referring to things related to bone, are still used commonly today. Some examples of terms used to describe bones include

910-422: A number of chemical enzymes that either promote or inhibit the activity of the bone remodeling cells, controlling the rate at which bone is made, destroyed, or changed in shape. The cells also use paracrine signalling to control the activity of each other. For example, the rate at which osteoclasts resorb bone is inhibited by calcitonin and osteoprotegerin . Calcitonin is produced by parafollicular cells in

1001-529: A positive correlation between the adaptations of resistance training and bone density. While nutritional and pharmacological approaches may also improve bone health, the strength and balance adaptations from resistance training are a substantial added benefit. Weight-bearing exercise may assist in osteoblast (bone-forming cells) formation and help to increase bone mineral content. High-impact sports, which involve quick changes in direction, jumping, and running, are particularly effective with stimulating bone growth in

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1092-419: A recent study, there was a strong correlation between calcium intake and BMD across a variety of diverse populations of children and adolescence ultimately coming to the conclusion that fundamentally, achieving optimal bone health is necessary for providing our youth with the ability to undergo hormonal changes as well. They found in a study of over 10,000 children ages 8-19 that in females, African Americans, and

1183-415: A seminomadic population, relocating on a regular basis as soil fertility and wild game populations declined in the immediate vicinity of their houses. Such relocations have become rarer as Awajún find their range of movement increasingly confined to titled community lands, which in some cases are now surrounded by the farms and villages of non-indigenous colonists. Major species of animals that are hunted by

1274-408: A smaller number of randomly oriented collagen fibers, but forms quickly; it is for this appearance of the fibrous matrix that the bone is termed woven . It is soon replaced by lamellar bone, which is highly organized in concentric sheets with a much lower proportion of osteocytes to surrounding tissue. Lamellar bone, which makes its first appearance in humans in the fetus during the third trimester,

1365-401: A strong nutritional plan with adequate amounts of Calcium sources can lead to strong bones but also can be a worth-while strategy into preventing further damage or degradation of bone stores as we age. The connection between Calcium intake & BMD and its effects on youth as a whole is a very world-wide issue and has been shown to affect different ethnicities in a variety of differing ways. In

1456-556: A traditional meeting in the form of an IPAAMAMU be held on Aguaruna territory. At the IPAAMAMU attended by over eighty representatives of sixty Aguaruna communities participants approved continuing negotiations and called upon CONAP, its legal adviser and a representative of the Peruvian Environmental Law Society (SPDA) to provide them with advice and support in the negotiations. The SPDA legal advisor,

1547-456: A very low shear stress strength (51.6 MPa). This means that bone resists pushing (compressional) stress well, resist pulling (tensional) stress less well, but only poorly resists shear stress (such as due to torsional loads). While bone is essentially brittle , bone does have a significant degree of elasticity , contributed chiefly by collagen . Mechanically, bones also have a special role in hearing . The ossicles are three small bones in

1638-441: Is mineralized tissue of two types, cortical bone and cancellous bone . Other types of tissue found in bones include bone marrow , endosteum , periosteum , nerves , blood vessels and cartilage . In the human body at birth, approximately 300 bones are present. Many of these fuse together during development, leaving a total of 206 separate bones in the adult, not counting numerous small sesamoid bones . The largest bone in

1729-474: Is called "osteoid". Around and inside collagen fibrils calcium and phosphate eventually precipitate within days to weeks becoming then fully mineralized bone with an overall carbonate substituted hydroxyapatite inorganic phase. In order to mineralise the bone, the osteoblasts secrete alkaline phosphatase, some of which is carried by vesicles . This cleaves the inhibitory pyrophosphate and simultaneously generates free phosphate ions for mineralization, acting as

1820-418: Is composed of a network of rod- and plate-like elements that make the overall organ lighter and allow room for blood vessels and marrow. Trabecular bone accounts for the remaining 20% of total bone mass but has nearly ten times the surface area of compact bone. The words cancellous and trabecular refer to the tiny lattice-shaped units (trabeculae) that form the tissue. It was first illustrated accurately in

1911-649: Is different from Wikidata All article disambiguation pages All disambiguation pages Aguaruna people The Awajún resisted efforts to incorporate them into the Inca and Spanish empires. Their reputation for fierceness and the difficult terrain in which they live prevented them from being incorporated into Peruvian national society until the late 1950s—and later still in some parts of their territory. Awajún families, either monogamous or polygamous , traditionally lived in dispersed neighborhoods of kin related through descent and marriage. Road construction and

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2002-589: Is less common to see, the necessity for a healthy routine especially when it comes to bone development is essential in our youth. Children that naturally have lower bone mineral density have a lower quality of life and therefore lead a life that is less fulfilling and uncomfortable. Factors such as increases in Calcium intake has been shown to increase BMD stores. Studies have shown that increasing calcium stores whether that be through supplementation or intake via foods and beverages such as leafy greens and milk have pushed

2093-518: Is mostly found in the bone marrow of the femur, the ribs, the vertebrae and pelvic bones . Bone receives about 10% of cardiac output. Blood enters the endosteum , flows through the marrow, and exits through small vessels in the cortex. In humans, blood oxygen tension in bone marrow is about 6.6%, compared to about 12% in arterial blood, and 5% in venous and capillary blood. Bone is metabolically active tissue composed of several types of cells. These cells include osteoblasts , which are involved in

2184-527: Is necessary during our childhood as these factors lead to a supportive and healthy lifestyle/bone health. Up till the age of 30, the bone stores that we have will ultimately start to decrease as we surpass this age. Influencing factors that can help us have larger stores and higher amounts of BMD will allow us to see less harmful results as we reach older adulthood. The issue of having fragile bones during our childhood leads to an increase in certain disorders and conditions such as juvenile osteoporosis , though it

2275-455: Is not fully known. Two types of bone can be identified microscopically according to the arrangement of collagen: woven and lamellar. Woven bone is produced when osteoblasts produce osteoid rapidly, which occurs initially in all fetal bones, but is later replaced by more resilient lamellar bone. In adults, woven bone is created after fractures or in Paget's disease . Woven bone is weaker, with

2366-403: Is not uniformly solid, but consists of a flexible matrix (about 30%) and bound minerals (about 70%), which are intricately woven and continuously remodeled by a group of specialized bone cells. Their unique composition and design allows bones to be relatively hard and strong, while remaining lightweight. Bone matrix is 90 to 95% composed of elastic collagen fibers, also known as ossein, and

2457-730: Is stimulated by the secretion of growth hormone by the pituitary , thyroid hormone and the sex hormones ( estrogens and androgens ). These hormones also promote increased secretion of osteoprotegerin. Osteoblasts can also be induced to secrete a number of cytokines that promote reabsorption of bone by stimulating osteoclast activity and differentiation from progenitor cells. Vitamin D , parathyroid hormone and stimulation from osteocytes induce osteoblasts to increase secretion of RANK- ligand and interleukin 6 , which cytokines then stimulate increased reabsorption of bone by osteoclasts. These same compounds also increase secretion of macrophage colony-stimulating factor by osteoblasts, which promotes

2548-561: Is stronger and filled with many collagen fibers parallel to other fibers in the same layer (these parallel columns are called osteons). In cross-section , the fibers run in opposite directions in alternating layers, much like in plywood , assisting in the bone's ability to resist torsion forces. After a fracture, woven bone forms initially and is gradually replaced by lamellar bone during a process known as "bony substitution". Compared to woven bone, lamellar bone formation takes place more slowly. The orderly deposition of collagen fibers restricts

2639-448: Is the osteon . Cancellous bone or spongy bone , also known as trabecular bone , is the internal tissue of the skeletal bone and is an open cell porous network that follows the material properties of biofoams . Cancellous bone has a higher surface-area-to-volume ratio than cortical bone and it is less dense . This makes it weaker and more flexible. The greater surface area also makes it suitable for metabolic activities such as

2730-492: Is very minimal. Being able to consistently meet calcium needs while also engaging in weight-bearing exercise is essential for building a strong initial bone foundation at which to build upon. Being able to reach our daily value of 1300mg for ages 9-18 is becoming more and more necessary and as we progress in health, the chance that osteoporosis and other factors such as bone fragility or potential for stunted growth can be greatly reduced through these resources, ultimately leading to

2821-641: Is widely regarded the most influential political entity representing the Aguaruna (and Huambisa) peoples, and played a central role in national level indigenous movements in Peru and in the founding of the Coordinating Body of Indigenous Organizations of the Amazon Basin (COICA), which represents Amazonian peoples from all over South America . In the mid-1990s Aguaruna were involved in negotiating

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2912-507: The Inca , although there are accounts of attempts to extend into the territory by Incas Huayna Capac and Tupac Inca Yupanqui . The Spanish conquistadors first encountered the Aguaruna in 1549 when the towns of Jaén de Bracamoros and Santa Maria de Nieva were founded. Fifty years later, a rebellion among the indigenous people forced the Spaniards out of the area. An agricultural colony

3003-598: The blowpipe . They gather the wild fruit of some palm trees , like the uvilla some shrubs , and buds of palm trees , as well as stems , bark , and resins . They extract leche caspi and gather the honey of wild bees , edible worms ( suris ), beetles , medicinal plants and lianas . They use everything that they gather either for food, crafts , traditional medicine , in witchcraft or as fuel , adhering to an ancestral pattern of self-sufficiency. The Awajún are known among naturalists for their sophisticated knowledge of rainforest flora and fauna, which has been

3094-724: The middle ear which are involved in sound transduction. The cancellous part of bones contain bone marrow . Bone marrow produces blood cells in a process called hematopoiesis . Blood cells that are created in bone marrow include red blood cells , platelets and white blood cells . Progenitor cells such as the hematopoietic stem cell divide in a process called mitosis to produce precursor cells. These include precursors which eventually give rise to white blood cells , and erythroblasts which give rise to red blood cells. Unlike red and white blood cells, created by mitosis, platelets are shed from very large cells called megakaryocytes . This process of progressive differentiation occurs within

3185-479: The osteonic canal . Volkmann's canals at right angles connect the osteons together. The columns are metabolically active, and as bone is reabsorbed and created the nature and location of the cells within the osteon will change. Cortical bone is covered by a periosteum on its outer surface, and an endosteum on its inner surface. The endosteum is the boundary between the cortical bone and the cancellous bone. The primary anatomical and functional unit of cortical bone

3276-420: The thyroid gland , and can bind to receptors on osteoclasts to directly inhibit osteoclast activity. Osteoprotegerin is secreted by osteoblasts and is able to bind RANK-L, inhibiting osteoclast stimulation. Osteoblasts can also be stimulated to increase bone mass through increased secretion of osteoid and by inhibiting the ability of osteoclasts to break down osseous tissue . Increased secretion of osteoid

3367-448: The 12-15 adolescent groups that at 2.6-2.8g/kg of body weight, they began to see a decrease in BMD. They elaborate on this by determining that this is strongly influenced by a lower baseline in calcium intake throughout puberty. Genetic factors have also been shown to influence lower acceptance of calcium stores. Ultimately, the window that youth have for accruing and building resilient bones

3458-457: The Aguaruna include the sajino , the huangana , the Brazilian tapir ( sachavaca ), the little red brocket , the ocelot and the otorongo ( jaguar ). Species which are less commonly hunted include the majaz , the ronsoco , the achuni , the añuje , the carachupa , the otter , diverse classes of monkeys and birds. The animals that they hunt not only provide meat ;

3549-462: The Aguarunas and the other inhabitants of the Peruvian rainforest . Their average height is taller – especially the men's – and their physical constitution denotes strength. The Aguarunas have a traditional, ideological and material culture, and they communicate with each other in their own language. A dictionary of this language, Vocabulario aguaruna del Amazonas (Aguaruna Vocabulary of Amazonas)

3640-538: The Irish lawyer Brendan Tobin, had repeatedly offered his legal services to the Consejo Aguaruna Huambisa (CAH), but they have refused. In significant measure, this was due to SPDA's tight relationship with the government of then Peruvian President Alberto Fujimori . The negotiations with OCCAAM and the other participating organizations led a group of agreements, including a "know-how license," which

3731-560: The Washington University scientists. Negotiations that began between Washington University and CAH on a bioprospecting agreement failed when Washington University's Walter Lewis collected Aguaruna medicinal plants and knowledge without a benefit-sharing agreement in place, leading to claims of biopiracy . The CAH terminated its relationship with Walter Lewis, Washington University, and their US government sponsors. As Tim Cahill wrote in his Outside magazine account of

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3822-420: The acellular component of bone consists of organic matter, while roughly 70% by mass is attributed to the inorganic phase. The collagen fibers give bone its tensile strength , and the interspersed crystals of hydroxyapatite give bone its compressive strength . These effects are synergistic . The exact composition of the matrix may be subject to change over time due to nutrition and biomineralization , with

3913-704: The basis of principles consistent with other rights of indigenous peoples . Aguaruna community organizations include the Organización Central de Comunidades Aguarunas del Alto Marañon (OCCAAM), founded in 1975, and the Consejo Aguaruna y Huambisa (CAH), an organization founded in 1977 that represents the Aguaruna and a closely related ethnic group, the Huambisa . Since then, Aguaruna community organizers have founded more than 12 local organizations (including an Aguaruna women's federation). The CAH

4004-479: The body is the femur or thigh-bone, and the smallest is the stapes in the middle ear . The Greek word for bone is ὀστέον (" osteon "), hence the many terms that use it as a prefix—such as osteopathy . In anatomical terminology , including the Terminologia Anatomica international standard, the word for a bone is os (for example, os breve , os longum , os sesamoideum ). Bone

4095-432: The body, and enable mobility . Bones come in a variety of shapes and sizes and have complex internal and external structures. They are lightweight yet strong and hard and serve multiple functions . Bone tissue (osseous tissue), which is also called bone in the uncountable sense of that word, is hard tissue , a type of specialised connective tissue . It has a honeycomb -like matrix internally, which helps to give

4186-416: The bone marrow. After the cells are matured, they enter the circulation . Every day, over 2.5 billion red blood cells and platelets, and 50–100 billion granulocytes are produced in this way. As well as creating cells, bone marrow is also one of the major sites where defective or aged red blood cells are destroyed. Determined by the species, age, and the type of bone, bone cells make up to 15 percent of

4277-548: The bone matrix. The release of these growth factors from the bone matrix could cause the proliferation of osteoblast precursors. Essentially, bone growth factors may act as potential determinants of local bone formation. Cancellous bone volume in postmenopausal osteoporosis may be determined by the relationship between the total bone forming surface and the percent of surface resorption. A number of diseases can affect bone, including arthritis, fractures, infections, osteoporosis and tumors. Conditions relating to bone can be managed by

4368-523: The bone rigidity. Bone tissue is made up of different types of bone cells . Osteoblasts and osteocytes are involved in the formation and mineralisation of bone; osteoclasts are involved in the resorption of bone tissue. Modified (flattened) osteoblasts become the lining cells that form a protective layer on the bone surface. The mineralised matrix of bone tissue has an organic component of mainly collagen called ossein and an inorganic component of bone mineral made up of various salts. Bone tissue

4459-429: The bone. Growth factor storage—mineralized bone matrix stores important growth factors such as insulin -like growth factors, transforming growth factor, bone morphogenetic proteins and others. Strong bones during our youth is essential for preventing osteoporosis and bone fragility as we age. The importance of insuring factors that could influence increases in BMD while lowering our risks for further bone degradation

4550-426: The breakdown of bones by the process of bone resorption . New bone is then formed by the osteoblasts. Bone is constantly remodeled by the resorption of osteoclasts and created by osteoblasts. Osteoclasts are large cells with multiple nuclei located on bone surfaces in what are called Howship's lacunae (or resorption pits ). These lacunae are the result of surrounding bone tissue that has been reabsorbed. Because

4641-458: The cartilage called "primary ossification centers". They mostly appear during fetal development, though a few short bones begin their primary ossification after birth . They are responsible for the formation of the diaphyses of long bones, short bones and certain parts of irregular bones. Secondary ossification occurs after birth and forms the epiphyses of long bones and the extremities of irregular and flat bones. The diaphysis and both epiphyses of

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4732-425: The coast or through rivers. They established themselves in a zone much wider than the one they occupy now. Apparently this zone also included the present-day Jaén . It is also said that they were influenced by cultural groups that were immigrants from the islands of Melanesia . They have always had the reputation of being brave warriors, standing out for their skills in war. Physically there are differences between

4823-447: The conversion of cartilage to bone: Bone development in youth is extremely important in preventing future complications of the skeletal system. Regular exercise during childhood and adolescence can help improve bone architecture, making bones more resilient and less prone to fractures in adulthood. Physical activity, specifically resistance training, stimulates growth of bones by increasing both bone density and strength. Studies have shown

4914-567: The creation and mineralization of bone tissue, osteocytes , and osteoclasts , which are involved in the reabsorption of bone tissue. Osteoblasts and osteocytes are derived from osteoprogenitor cells, but osteoclasts are derived from the same cells that differentiate to form macrophages and monocytes . Within the marrow of the bone there are also hematopoietic stem cells . These cells give rise to other cells, including white blood cells , red blood cells , and platelets . Osteoblasts are mononucleate bone-forming cells. They are located on

5005-641: The differentiation of progenitor cells into osteoclasts, and decrease secretion of osteoprotegerin. Bone volume is determined by the rates of bone formation and bone resorption. Certain growth factors may work to locally alter bone formation by increasing osteoblast activity. Numerous bone-derived growth factors have been isolated and classified via bone cultures. These factors include insulin-like growth factors I and II, transforming growth factor-beta, fibroblast growth factor, platelet-derived growth factor, and bone morphogenetic proteins. Evidence suggests that bone cells produce growth factors for extracellular storage in

5096-499: The ends of which they place feathers and human hair. These adornments are kept in bamboo cases. The real origin of the Aguaruna people is still a mystery. In accordance with the racial characteristics of the majority, some anthropologists suppose that they came down the Andes centuries ago and adapted themselves to the geographical conditions of the region. Others believe that they are emigrants of Central America who came either by

5187-453: The engravings of Crisóstomo Martinez . Bone marrow , also known as myeloid tissue in red bone marrow, can be found in almost any bone that holds cancellous tissue . In newborns , all such bones are filled exclusively with red marrow or hematopoietic marrow, but as the child ages the hematopoietic fraction decreases in quantity and the fatty/ yellow fraction called marrow adipose tissue (MAT) increases in quantity. In adults, red marrow

5278-636: The establishment of bilingual schools and health posts has led to a more clustered settlement pattern and in some cases the appearance of densely populated hamlets. Examples of Awajún towns include Yutupiza on the Santiago River and Japaime on the Nieva . The towns for which there exists a pattern of nucleate population are called "yáakat" in their native language, and do not have streets, footpaths, or squares, but rather are constituted of houses of traditional construction. These houses are distributed in

5369-429: The exchange of calcium ions. Cancellous bone is typically found at the ends of long bones, near joints, and in the interior of vertebrae. Cancellous bone is highly vascular and often contains red bone marrow where hematopoiesis , the production of blood cells, occurs. The primary anatomical and functional unit of cancellous bone is the trabecula . The trabeculae are aligned towards the mechanical load distribution that

5460-410: The foci for calcium and phosphate deposition. Vesicles may initiate some of the early mineralization events by rupturing and acting as a centre for crystals to grow on. Bone mineral may be formed from globular and plate structures, and via initially amorphous phases. Five types of bones are found in the human body: long, short, flat, irregular, and sesamoid. In the study of anatomy , anatomists use

5551-590: The focus of extensive studies by ethnobotanists and ethnozoologists. As agricultural instruments, they use the traditional wái (a stick with a sharp end, made from the wood of the pijuayo palm tree ), along with the axe , the machete and the shovel . The principal crafts are masculine activities like ropemaking , basketry , the construction of canoes , and textiles ; and feminine activities like ceramics and making necklaces from seeds , insects ' small wings and beads . The men make headdresses of exquisite feathers as well as cotton ribbons on

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5642-410: The formation of bone from cartilage . Intramembranous ossification mainly occurs during formation of the flat bones of the skull but also the mandible, maxilla, and clavicles; the bone is formed from connective tissue such as mesenchyme tissue rather than from cartilage. The process includes: the development of the ossification center , calcification , trabeculae formation and the development of

5733-590: The formation of osteoid to about 1 to 2  μm per day. Lamellar bone also requires a relatively flat surface to lay the collagen fibers in parallel or concentric layers. The extracellular matrix of bone is laid down by osteoblasts , which secrete both collagen and ground substance. These cells synthesise collagen alpha polypetpide chains and then secrete collagen molecules. The collagen molecules associate with their neighbors and crosslink via lysyl oxidase to form collagen fibrils. At this stage, they are not yet mineralized, and this zone of unmineralized collagen fibrils

5824-475: The groundwork for bone health later in life, reducing the risk of bone-related conditions such as osteoporosis. Bones have a variety of functions: Bones serve a variety of mechanical functions. Together the bones in the body form the skeleton . They provide a frame to keep the body supported, and an attachment point for skeletal muscles , tendons , ligaments and joints , which function together to generate and transfer forces so that individual body parts or

5915-522: The jetty of the army outpost at Urakuza but has not shared its findings with civilian authorities. After that, Washington University entered into negotiations with OCCAAM as well as their national representative organization the Confederación de Nacionalidades Amazónicas del Perú (CONAP). One of the first demands of these organisations was that all material and knowledge previously collected by Washington University be returned. They also demanded that

6006-405: The later half of the 20th century, the arrival of Protestant and Jesuit missionaries, the building of roads, and the construction of an oil pipeline created substantial tension between the Aguaruna people, poor agricultural colonists, state agencies, and corporations. In response to new threats to their way of life the Aguaruna began to organize a political and social response to defend themselves on

6097-487: The notion that prepuberty or even early pubertal children will see increases in BMD with the addition of increase Calcium intake. Another research study goes on to show that long-term calcium intake has been proven to significantly contribute to overall BMD in children without certain conditions or disorders. This data shows that ensuring adequate calcium intake in children reinforces the structure and rate at which bones will begin to densify. Further detailing how structuring

6188-478: The osteoblast puts up collagen fibers. These collagen fibers are used as a framework for the osteoblasts' work. The osteoblast then deposits calcium phosphate which is hardened by hydroxide and bicarbonate ions. The brand-new bone created by the osteoblast is called osteoid . Once the osteoblast is finished working it is actually trapped inside the bone once it hardens. When the osteoblast becomes trapped, it becomes known as an osteocyte. Other osteoblasts remain on

6279-502: The osteoclasts are derived from a monocyte stem-cell lineage, they are equipped with phagocytic -like mechanisms similar to circulating macrophages . Osteoclasts mature and/or migrate to discrete bone surfaces. Upon arrival, active enzymes, such as tartrate-resistant acid phosphatase , are secreted against the mineral substrate. The reabsorption of bone by osteoclasts also plays a role in calcium homeostasis . Bones consist of living cells (osteoblasts and osteocytes) embedded in

6370-456: The osteocyte cell processes occupy channels called canaliculi. The many processes of osteocytes reach out to meet osteoblasts, osteoclasts, bone lining cells, and other osteocytes probably for the purposes of communication. Osteocytes remain in contact with other osteocytes in the bone through gap junctions—coupled cell processes which pass through the canalicular channels. Osteoclasts are very large multinucleate cells that are responsible for

6461-427: The periosteum. Endochondral ossification occurs in long bones and most other bones in the body; it involves the development of bone from cartilage. This process includes the development of a cartilage model, its growth and development, development of the primary and secondary ossification centers , and the formation of articular cartilage and the epiphyseal plates . Endochondral ossification begins with points in

6552-684: The ratio of calcium to phosphate varying between 1.3 and 2.0 (per weight), and trace minerals such as magnesium , sodium , potassium and carbonate also be found. Type I collagen composes 90–95% of the organic matrix, with the remainder of the matrix being a homogenous liquid called ground substance consisting of proteoglycans such as hyaluronic acid and chondroitin sulfate , as well as non-collagenous proteins such as osteocalcin , osteopontin or bone sialoprotein . Collagen consists of strands of repeating units, which give bone tensile strength, and are arranged in an overlapping fashion that prevents shear stress. The function of ground substance

6643-462: The remainder is ground substance . The elasticity of collagen improves fracture resistance. The matrix is hardened by the binding of inorganic mineral salt, calcium phosphate , in a chemical arrangement known as bone mineral , a form of calcium apatite . It is the mineralization that gives bones rigidity. Bone is actively constructed and remodeled throughout life by special bone cells known as osteoblasts and osteoclasts. Within any single bone,

6734-498: The same university profiting from the arrangement and, in any event, the license earned nobody any money or fame except the SPDA advisor. For the Aguaruna, it earned them nothing. Bone A bone is a rigid organ that constitutes part of the skeleton in most vertebrate animals. Bones protect the various other organs of the body, produce red and white blood cells , store minerals , provide structure and support for

6825-578: The skeletal mass of an adult is remodelled each year. The purpose of remodeling is to regulate calcium homeostasis , repair microdamaged bones from everyday stress, and to shape the skeleton during growth. Repeated stress, such as weight-bearing exercise or bone healing, results in the bone thickening at the points of maximum stress ( Wolff's law ). It has been hypothesized that this is a result of bone's piezoelectric properties, which cause bone to generate small electrical potentials under stress. The action of osteoblasts and osteoclasts are controlled by

6916-428: The skin, feathers , teeth and bones are also used. Hunting therefore has a double purpose: for dietary needs and also for making handicrafts, medicines and items used in witchcraft . Traditionally, the tribe hunted with a spear perfected with pijuayo (a palm tree of very hard wood) and the blowpipe . At present the spear has been almost completely displaced by the pellet shotgun but they also continue using

7007-425: The souls of dead warriors, and if the young man showed no fear he would receive spirit power known as ajútap . A man with such spirit power would be invulnerable in battle. In the distant past, the Aguarunas engaged in the practice of shrinking human heads to make tsantsa . Evangelical missionaries began contacting the Aguaruna in the mid-20th century, and today many Aguarunas have converted to Christianity. In

7098-469: The surface of osteon seams and make a protein mixture known as osteoid , which mineralizes to become bone. The osteoid seam is a narrow region of a newly formed organic matrix, not yet mineralized, located on the surface of a bone. Osteoid is primarily composed of Type I collagen . Osteoblasts also manufacture hormones , such as prostaglandins , to act on the bone itself. The osteoblast creates and repairs new bone by actually building around itself. First,

7189-450: The term "foramen" to describe a hole through which something passes, and a "canal" or "meatus" to describe a tunnel-like structure. A protrusion from a bone can be called a number of terms, including a "condyle", "crest", "spine", "eminence", "tubercle" or "tuberosity", depending on the protrusion's shape and location. In general, long bones are said to have a "head", "neck", and "body". When two bones join, they are said to "articulate". If

7280-419: The tissue is woven into two main patterns, known as cortical and cancellous bone, each with a different appearance and characteristics. The hard outer layer of bones is composed of cortical bone , which is also called compact bone as it is much denser than cancellous bone. It forms the hard exterior (cortex) of bones. The cortical bone gives bone its smooth, white, and solid appearance, and accounts for 80% of

7371-417: The top of the new bone and are used to protect the underlying bone, these become known as bone lining cells. Osteocytes are cells of mesenchymal origin and originate from osteoblasts that have migrated into and become trapped and surrounded by a bone matrix that they themselves produced. The spaces the cell body of osteocytes occupy within the mineralized collagen type I matrix are known as lacunae , while

7462-412: The total bone mass of an adult human skeleton . It facilitates bone's main functions—to support the whole body, to protect organs, to provide levers for movement, and to store and release chemical elements, mainly calcium. It consists of multiple microscopic columns, each called an osteon or Haversian system. Each column is multiple layers of osteoblasts and osteocytes around a central canal called

7553-750: The transandean oil pipeline and the medicinal plant industry also play roles in the local economy. The Aguarunas traditionally believed in many spirits and mythological figures, among them: Zeus , or the Sun; Núgkui , or Mother Earth, Pachamama who ensures agricultural success and provides the clay for ceramics; Tsúgki , water spirits who live in the rivers; and Bikut , or father shaman, who transforms himself into hallucinogenic plants that, mixed with ayahuasca , drugs allows one to communicate with powerful spirit but killed half population-beings. Young men would traditionally take hallucinogenic plants including ayahuasca to give them visions. The visions were believed to be

7644-641: The two Americans were mistaken by the Aguaruna for Washington University specimen hunters. It is also possible the Peruvian Army suspected them of espionage on the eve of the outbreak of war with Ecuador in the nearby border area. Despite Embassy attempts to elicit strong action, the Peruvian government showed no serious effort to investigate the killing, leaving the investigation to the poorly equipped local police outpost at Nieva. The Army conducted its own investigation immediately after Josh Silver showed up on

7735-418: The two bones have a fibrous connection and are relatively immobile, then the joint is called a "suture". The formation of bone is called ossification . During the fetal stage of development this occurs by two processes: intramembranous ossification and endochondral ossification . Intramembranous ossification involves the formation of bone from connective tissue whereas endochondral ossification involves

7826-430: The whole body can be manipulated in three-dimensional space (the interaction between bone and muscle is studied in biomechanics ). Bones protect internal organs, such as the skull protecting the brain or the ribs protecting the heart and lungs . Because of the way that bone is formed, bone has a high compressive strength of about 170  MPa (1,700  kgf/cm ), poor tensile strength of 104–121 MPa, and

7917-421: The youth. Sports such as soccer, basketball, and tennis have shown to have positive effects on bone mineral density as well as bone mineral content in teenagers. Engaging in physical activity during childhood years, particularly in these high-impact osteogenic sports, can help to positively influence bone mineral density in adulthood. Children and adolescents who participate in regular physical activity will place

8008-399: Was compiled by Mildred L. Larson and published by SIL International in 1966. The Aguarunas are located in the geographical area of the Marañón river, that is to say on the banks of the Marañón river and of its tributaries, the rivers Santiago, Nieva , Cenepa , Numpatakay and Chiriaco . Unlike many other cultural groups in what is now Peru, the Aguaruna were never successfully conquered by

8099-472: Was entered into by the participating Agaurauna organizations, CONAP, and Monsanto's pharmaceutical arm Searle and Company. The licensing arrangement was designed to give the Aguarunas greater control over the use of their knowledge once it left their direct control. The "know-how license" concept as applied to indigenous peoples' knowledge is a legal first, according to Professor Charles McManis of Washington University School of Law . Professor McManis worked for

8190-507: Was later established at Borja in 1865. Attempts by Dominican and Jesuit missionaries to convert the Aguarunas were largely unsuccessful. Traditionally, the economy of the Aguaruna was based mostly on hunting, fishing and subsistence agriculture. However, over the last few decades they have increasingly become engaged in capitalism. Some communities now cultivate rice, coffee, cocoa and bananas for sale, either in local markets or for transport to coastal cities like Chiclayo . Maintenance of

8281-494: Was treated for his wounds at an army base and then transferred to a hospital in Santa María de Nieva. The American consul general in Peru, Thomas Holladay, was informed that two Americans had been attacked. One was alive; the other was missing and feared dead." Patchen's body was never recovered nor the crime solved. The attackers were drunk Aguarunas, probably from the nearby village of Huaracayo. There has been speculation that

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