Misplaced Pages

#119880

102-413: Alligators and crocodiles are not truly domesticated and their being bred in farms probably began as late as the early 20th century. Most of the early businesses, such as St. Augustine Alligator Farm Zoological Park , established in 1893, were farms in name only, primarily keeping alligators and crocodiles as a tourist attraction . Only in the 1960s did commercial operations that either harvested eggs from

204-662: A Science article reported that China had approved CanSino 's Ebola vaccine based on an Ad5 vector. It was tested in Sierra Leone , which had high HIV prevalence , making it more likely for such problems to be detected. CanSino's CEO said "we haven't seen anything with the Ebola vaccine" and speculated that HIV susceptibility might be limited to Ad5 vaccines which produced HIV proteins. In research reported in The Lancet in May,

306-420: A "broad" definition: "a coevolutionary process that arises from a mutualism, in which one species (the domesticator) constructs an environment where it actively manages both the survival and reproduction of another species (the domesticate) in order to provide the former with resources and/or services." He comments that this adds niche construction to the activities of the domesticator. Domestication syndrome

408-594: A broad range of vertebrate hosts; in humans, more than 50 distinct adenoviral serotypes have been found to cause a wide range of illnesses , from mild respiratory infections in young children (known as the common cold ) to life-threatening multi-organ disease in people with a weakened immune system . This family contains the following genera : In humans, currently there are 88 human adenoviruses (HAdVs) in seven species (Human adenovirus A to G): Different types/serotypes are associated with different conditions: All these types are called Human mastadenovirus A–G by

510-426: A decade, was shipped to basic training sites on 18 October 2011. Prevention of adenovirus, as well as other respiratory illnesses, involves frequent hand washing for more than 20 seconds, avoiding touching the eyes, face, and nose with unwashed hands, and avoiding close contact with people with symptomatic adenovirus infection. Those with symptomatic adenovirus infection are additionally advised to cough or sneeze into

612-860: A few have been domesticated, including squid , cuttlefish and octopus , all used in research on behaviour and neurology . Terrestrial snails in the genera Helix are raised for food. Several parasitic or parasitoidal insects, including the fly Eucelatoria , the beetle Chrysolina , and the wasp Aphytis are raised for biological control. Conscious or unconscious artificial selection has many effects on species under domestication; variability can readily be lost by inbreeding, selection against undesired traits, or genetic drift, while in Drosophila , variability in eclosion time (when adults emerge) has increased. Humans foraged for wild cereals, seeds, and nuts thousands of years before they were domesticated; wild wheat and barley, for example, were gathered in

714-454: A linear dsDNA genome and are able to replicate in the nucleus of vertebrate cells using the host's replication machinery. Entry of adenoviruses into the host cell involves two sets of interactions between the virus and the host cell. Most of the action occurs at the vertices. Entry into the host cell is initiated by the knob domain of the fiber protein binding to the cell receptor. The two currently established receptors are: CD46 for

816-423: A major effort is made to limit hepatotoxicity and prevent multiple organ failure. Adenovirus dodecahedron can qualify as a potent delivery platform for foreign antigens to human myeloid dendritic cells (MDC), and that it is efficiently presented by MDC to M1-specific CD8+ T lymphocytes. A safety issue with adenoviruses is that they can cause an immune response with a related inflammatory response as occurred in

918-484: A means of communication between far-flung places through the exploitation of the pigeon's homing instinct; research suggests it was domesticated as early as 10,000 years ago. Chicken fossils in China have been dated to 7,400 years ago. The chicken's wild ancestor is Gallus gallus , the red junglefowl of Southeast Asia. The species appears to have been kept initially for cockfighting rather than for food. Two insects ,

1020-468: A population bottleneck where genetic drift is enhanced by the small population size. Mutations can also be fixed in a population by a selective sweep . Mutational load can be increased by reduced selective pressure against moderately harmful traits when reproductive fitness is controlled by human management. However, there is evidence against a bottleneck in crops, such as barley, maize, and sorghum, where genetic diversity slowly declined rather than showing

1122-432: A potentially fatal disease involving vasculitis and hepatitis . Type 1 infection can also cause respiratory and eye infections. CAdV-1 also affects foxes ( Vulpes vulpes and Vulpes lagopus ) and may cause hepatitis and encephalitis. Canine adenovirus 2 (CAdV-2) is one of the potential causes of kennel cough . Core vaccines for dogs include attenuated live CAdV-2, which produces immunity to CAdV-1 and CAdV-2. CAdV-1

SECTION 10

#1732790635120

1224-779: A predictable supply of a resource, resulting in mutual benefits . She noted further that it is not synonymous with agriculture since agriculture depends on domesticated organisms but does not automatically result from domestication. Michael D. Purugganan notes that domestication has been hard to define, despite the "instinctual consensus" that it means "the plants and animals found under the care of humans that provide us with benefits and which have evolved under our control." He comments that insects such as termites , ambrosia beetles , and leafcutter ants have domesticated some species of fungi , and notes further that other groups such as weeds and commensals have wrongly been called domesticated. Starting from Zeder's definition, Purugganan proposes

1326-425: A protracted coevolutionary process with multiple stages along different pathways. There are three proposed major pathways that most mammal domesticates followed into domestication: Humans did not intend to domesticate mammals from either the commensal or prey pathways, or at least they did not envision a domesticated animal would result from it. In both of those cases, humans became entangled with these species as

1428-575: A rapid initial fall at the point of domestication. Further, the genetic diversity of these crops was regularly replenished from the natural population. Similar evidence exists for horses, pigs, cows, and goats. At least three groups of insects, namely ambrosia beetles, leafcutter ants, and fungus-growing termites, have domesticated species of fungi . Ambrosia beetles in the weevil subfamilies Scolytinae and Platypodinae excavate tunnels in dead or stressed trees into which they introduce fungal gardens, their sole source of nutrition. After landing on

1530-457: A steady supply of resources, such as meat, milk, or labor. The process is gradual and geographically diffuse, based on trial and error. Domestication affected genes for behavior in animals, making them less aggressive. In plants, domestication affected genes for morphology, such as increasing seed size and stopping the shattering of cereal seedheads. Such changes both make domesticated organisms easier to handle and reduce their ability to survive in

1632-402: A suitable tree, an ambrosia beetle excavates a tunnel in which it releases its fungal symbiont . The fungus penetrates the plant's xylem tissue, extracts nutrients from it, and concentrates the nutrients on and near the surface of the beetle gallery. Ambrosia fungi are typically poor wood degraders and instead utilize less demanding nutrients. Symbiotic fungi produce and detoxify ethanol, which

1734-419: A vehicle to administer targeted therapy , in the form of recombinant DNA or protein. This therapy has been found especially useful in treating monogenic disease (e.g. cystic fibrosis , X-linked SCID , alpha1-antitrypsin deficiency) and cancer. In China, oncolytic adenovirus is an approved cancer treatment. Specific modifications on fiber proteins are used to target Adenovirus to certain cell types;

1836-509: A wide range of responses, from no symptoms at all to the severe infections typical of Adenovirus serotype 14 . Bat adenovirus TJM (Bt-AdV-TJM) is a novel species of the Mastadenovirus genus isolated from Myotis and Scotophilus kuhlii in China. It is most closely related to the tree shrew and canine AdVs. Two types of canine adenoviruses are well known, type 1 and 2. Type 1 (CAdV-1) causes infectious canine hepatitis ,

1938-474: A working animal. Among invertebrates , the silkworm and the western honey bee were domesticated over 5,000 years ago for silk and honey , respectively. The domestication of plants began around 13,000–11,000 years ago with cereals such as wheat and barley in the Middle East , alongside crops such as lentil , pea , chickpea , and flax . Beginning around 10,000 years ago, Indigenous peoples in

2040-405: Is an attractant for ambrosia beetles and likely prevents the growth of antagonistic pathogens and selects for other beneficial symbionts. Ambrosia beetles mainly colonise wood of recently dead trees. The leafcutter ants are any of some 47 species of leaf-chewing ants in the genera Acromyrmex and Atta . The ants carry the discs of leaves that they have cut back to their nest, where they feed

2142-718: Is caused by Parapoxvirus, affecting hatchlings and juveniles. It causes a brown residue to form around the eyes, oral cavity, and tail. Caiman pox similarly causes white lesions around the eyes, oral cavity, and tail. Adenoviral hepatitis causes organ failure and death. Mycoplasmosis causes polyarthritis and pneumonia in crocodilians under the age of three. Infected animals have swollen jaws and are unable to move. Chlamydiosis has two forms that affects juveniles under one year of age. The first causes acute hepatitis, usually resulting in death. The other causes chronic bilateral conjunctivitis, usually resulting in blindness. Parasitic infections include tapeworm cysts, Trichinella spiralis nelsoni in

SECTION 20

#1732790635120

2244-432: Is domesticated wheat, which relies on farmers for its reproduction and dissemination. Domesticated plants differ from their wild relatives in many ways, including Plant defenses against herbivory , such as thorns, spines, and prickles , poison, protective coverings, and sturdiness may have been reduced in domesticated plants. This would make them more likely to be eaten by herbivores unless protected by humans, but there

2346-564: Is found to be present, it may not be the cause of any symptoms. Some immunocompromised individuals can shed the virus for weeks and show no symptoms. Most infections with adenovirus result in infections of the upper respiratory tract. Adenovirus infections often present as conjunctivitis , tonsillitis (which may look exactly like strep throat and cannot be distinguished from strep except by throat culture), an ear infection , or croup . Adenoviruses types 40 and 41 can also cause gastroenteritis . A combination of conjunctivitis and tonsillitis

2448-419: Is innovative because an Ad26 based vaccine is used on the first day and an Ad5 vaccine is used on day 21. Another one is ChAd-SARS-CoV-2-S ; the vaccine reportedly prevented mice that were genetically modified to have human ACE2 (hACE2) receptors, presumably receptors that allow virus-entry into the cells, from being infected with SARS-CoV-2. Possible issues with using Adenovirus as vaccine vectors include:

2550-511: Is largely directed at the symptoms (such as acetaminophen for fever). The antiviral drug cidofovir has helped certain of those patients who had severe cases of illness; the number helped and to what degree, and the particular complications or symptoms it helped with, and when and where this happened, were not given in the source. A doctor may give antibiotic eyedrops for conjunctivitis, while awaiting results of bacterial cultures, and to help prevent secondary bacterial infections. Currently, there

2652-501: Is no adenovirus vaccine available to the general public, but a vaccine is available for the United States military for Types 4 and 7. Adenoviruses have long been a popular viral vector for gene therapy due to their ability to affect both replicating and non-replicating cells, accommodate large transgenes , and code for proteins without integrating genetic material into the host cell genome. More specifically, they are used as

2754-669: Is only weak support for most of this. Farmers did select for reduced bitterness and lower toxicity and for food quality, which likely increased crop palatability to herbivores as to humans. However, a survey of 29 plant domestications found that crops were as well-defended against two major insect pests ( beet armyworm and green peach aphid ) both chemically (e.g. with bitter substances) and morphologically (e.g. with toughness) as their wild ancestors. During domestication, crop species undergo intense artificial selection that alters their genomes, establishing core traits that define them as domesticated, such as increased grain size. Comparison of

2856-412: Is particularly common with adenovirus infections. Some children (especially the youngest) can develop adenovirus bronchiolitis or pneumonia , both of which can be severe. In babies, adenoviruses can also cause coughing fits that look almost exactly like whooping cough . Adenoviruses can also cause viral meningitis or encephalitis . Rarely, adenovirus can cause hemorrhagic cystitis (inflammation of

2958-420: Is reduced. Juvenile crocodilians can also be released into the wild to support a steady population. Wild alligator conservation has also benefited indirectly from farming. Ranching businesses protect alligator habitats to take care of nesting sites. The fiscal incentive to keep a healthy environment for breeding alligators means that the environment and its wildlife are seen as an economic resource. This can augment

3060-466: Is separated by the DNA replication process into two phases: an early and a late phase. In both phases, a primary transcript that is alternatively spliced to generate monocistronic mRNAs compatible with the host's ribosome is generated, allowing for the products to be translated . The early genes are responsible for expressing mainly non-structural, regulatory proteins . The goal of these proteins

3162-495: Is significantly larger than other viruses in its Baltimore group , it is still a very simple virus and is heavily reliant on the host cell for survival and replication. The genes of adenoviruses can generally be divided into well-conserved sets of transcription units with six early transcription units (E1A, E1B, E2A, E2B, E3 and E4) and one late transcription unit ranging from L1-L5. In addition, adenoviruses also contain two intermediate transcription units named XI and IVa2. To increase

Crocodile farm - Misplaced Pages Continue

3264-465: Is subsequently released, which can enter the nucleus via the nuclear pore . After this the DNA associates with histone molecules already present in the nucleus, which allows it to interact with the host cell transcription machinery. Then, viral gene expression can occur, without integrating the viral genome into host cell chromosomes, and new virus particles can be generated. The adenovirus life cycle

3366-668: Is the suite of phenotypic traits that arose during the initial domestication process and which distinguish crops from their wild ancestors . It can also mean a set of differences now observed in domesticated mammals, not necessarily reflecting the initial domestication process. The changes include increased docility and tameness, coat coloration, reductions in tooth size, craniofacial morphology, ear and tail form (e.g., floppy ears), estrus cycles, levels of adrenocorticotropic hormone and neurotransmitters, prolongations in juvenile behavior, and reductions in brain size and of particular brain regions. The domestication of animals and plants

3468-658: Is threefold: to alter the expression of host proteins that are necessary for DNA synthesis ; to activate other virus genes (such as the virus-encoded DNA polymerase ); and to avoid premature death of the infected cell by the host-immune defenses (blockage of apoptosis , blockage of interferon activity, and blockage of MHC class I translocation and expression). Some adenoviruses under specialized conditions can transform cells using their early gene products. E1A (binds Retinoblastoma tumor suppressor protein ) has been found to immortalize primary cells in vitro allowing E1B (binds p53 tumor suppressor) to assist and stably transform

3570-725: Is today Baluchistan in Pakistan. In East Asia 8,000 years ago, pigs were domesticated from wild boar genetically different from those found in the Fertile Crescent. The cat was domesticated in the Fertile Crescent, perhaps 10,000 years ago, from European wildcats , possibly to control rodents that were damaging stored food. The domestication of vertebrate animals is the relationship between non-human vertebrates and humans who have an influence on their care and reproduction. In his 1868 book The Variation of Animals and Plants Under Domestication , Charles Darwin recognized

3672-790: Is transmitted by mosquitoes. WNV has been found in Mexico at a crocodile farm in Ciudad del Carmen . The skin, most notably the underside, of alligators and crocodiles is of commercial value, so diseases of the skin need to be treated properly and effectively. Crocodilian diseases vary between species. Salmonellosis is common on some farms, and is acquired from infected food; it may also be spread by poor hygiene practices. Chlamydia , (specifically Chlamydophila psittaci ) can persist for years if not treated, for example with tetracycline . Crocodilians may acquire mycobacteria from infected meat. Illnesses affecting crocodilians include crocodile pox, which

3774-636: Is widely grown for food. The yeast Saccharomyces cerevisiae have been used for thousands of years to ferment beer and wine , and to leaven bread . Mould fungi including Penicillium are used to mature cheeses and other dairy products, as well as to make drugs such as antibiotics . Selection of animals for visible traits may have undesired consequences for the genetics of domestic animals. A side effect of domestication has been zoonotic diseases. For example, cattle have given humanity various viral poxes , measles , and tuberculosis ; pigs and ducks have contributed influenza ; and horses have brought

3876-463: The host cell via the receptor on its surface. In 2010, the structure of the human adenovirus was solved at the atomic level, making it the largest high-resolution model ever. The virus is composed of around 1 million amino acid residues and weighs around 150 MDa . The adenovirus genome is linear, non-segmented double-stranded (ds) DNA that is between 26 and 48 k bp . This allows the virus to theoretically carry 22 to 40 genes . Although this

3978-466: The ICTV , because all are members of the genus Mastadenovirus . Adenoviruses are medium-sized (90–100 nm). The virions are composed of one linear piece of double-stranded DNA inside an icosahedral capsid . 240 hexon proteins make up the bulk of the capsid, while twelve penton bases cap the icosahedron's corners. The penton bases are associated with protruding fibers that aid in attachment to

4080-718: The Indian Ocean and those in the Pacific Ocean . The coconut experienced a founder effect , where a small number of individuals with low diversity founded the modern population, permanently losing much of the genetic variation of the wild population. Population bottlenecks which reduced variation throughout the genome at some later date after domestication are evident in crops such as pearl millet , cotton , common bean and lima bean . In wheat, domestication involved repeated hybridization and polyploidy . These steps are large and essentially instantaneous changes to

4182-634: The Levant at least 23,000 years ago. Neolithic societies in West Asia first began to cultivate and then domesticate some of these plants around 13,000 to 11,000 years ago. The founder crops of the West Asian Neolithic included cereals ( emmer , einkorn wheat , barley ), pulses ( lentil , pea , chickpea , bitter vetch ), and flax . Other plants were independently domesticated in 13 centers of origin (subdivided into 24 areas) of

Crocodile farm - Misplaced Pages Continue

4284-619: The coding DNA of chromosome 8 in rice between fragrant and non-fragrant varieties showed that aromatic and fragrant rice, including basmati and jasmine , is derived from an ancestral rice domesticate that suffered a deletion in exon 7 which altered the coding for betaine aldehyde dehydrogenase (BADH2). Comparison of the potato genome with that of other plants located genes for resistance to potato blight caused by Phytophthora infestans . In coconut , genomic analysis of 10 microsatellite loci (of noncoding DNA ) found two episodes of domestication based on differences between individuals in

4386-470: The domestication of wheat . Wild wheat shatters and falls to the ground to reseed itself when ripe, but domesticated wheat stays on the stem for easier harvesting. This change was possible because of a random mutation in the wild populations at the beginning of wheat's cultivation . Wheat with this mutation was harvested more frequently and became the seed for the next crop. Therefore, without realizing it, early farmers selected for this mutation. The result

4488-417: The domestication syndrome , traits presumed essential in the early stages of domestication, while others represent later improvement traits. Domesticated mammals in particular tend to be smaller and less aggressive than their wild counterparts; other common traits are floppy ears, a smaller brain, and a shorter muzzle. Domestication traits are generally fixed within all domesticates, and were selected during

4590-437: The rhinoviruses . Many parasites , too, have their origins in domestic animals. Alongside these, the advent of domestication resulted in denser human populations, which provided ripe conditions for pathogens to reproduce, mutate, spread, and eventually find a new host in humans. Scholars have expressed widely differing viewpoints on domestication's effects on society. Anarcho-primitivism critiques domestication as destroying

4692-436: The silkworm and the western honey bee , have been domesticated for over 5,000 years, often for commercial use. The silkworm is raised for the silk threads wound around its pupal cocoon; the western honey bee, for honey , and, from the 20th century, for pollination of crops. Several other invertebrates have been domesticated, both terrestrial and aquatic, including some such as Drosophila melanogaster fruit flies and

4794-514: The spectacled caiman does take place in South America. Farming alligators and crocodiles first grew out of the demand for skins, which can fetch hundreds of dollars each. But alligator and crocodile meat, long a part of Southern cooking (especially Cajun cuisine ) and some Asian and African cuisines , began to be sold and shipped to markets unfamiliar with crocodilian meat. Chinese cuisine based on traditional Chinese medicine considers

4896-648: The 'vector' to transport the surface protein gene of SARS-CoV-2". The goal is to genetically express the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ). A replication-deficient chimpanzee adenovirus vaccine vector (ChAdOx1) is used by the Oxford–AstraZeneca COVID-19 vaccine that has been approved for use. The Janssen COVID-19 vaccine uses modified recombinant adenovirus type-26 (Ad26). Recombinant adenovirus type-5 (Ad5) are being used by Ad5-nCoV , ImmunityBio and UQ-CSL V451 . The Gam-COVID-Vac (aka Sputnik-V) product

4998-555: The Americas began to cultivate peanuts , squash , maize , potatoes , cotton , and cassava . Rice was first domesticated in China some about 9,000 years ago. In Africa, crops such as sorghum were domesticated. Agriculture developed in some 13 centres around the world, domesticating different crops and animals. Three groups of insects, namely ambrosia beetles , leafcutter ants , and fungus-growing termites have independently domesticated species of fungi, on which they feed. In

5100-592: The Americas, Africa, and Asia (the Middle East, South Asia, the Far East, and New Guinea and Wallacea); in some thirteen of these regions people began to cultivate grasses and grains. Rice was first cultivated in East Asia. Sorghum was widely cultivated in sub-Saharan Africa, while peanuts, squash, cotton, maize , potatoes , and cassava were domesticated in the Americas. Continued domestication

5202-595: The Late Pleistocene. Domestication reduces genetic diversity of the domesticated population, especially of alleles of genes targeted by selection. One reason is a population bottleneck created by artificially selecting the most desirable individuals to breed from. Most of the domesticated strain is then born from just a few ancestors, creating a situation similar to the founder effect . Domesticated populations such as of dogs, rice, sunflowers, maize, and horses have an increased mutation load , as expected in

SECTION 50

#1732790635120

5304-634: The Southern U.S. states of Louisiana , Florida , and Georgia , the practice quickly spread to other nations. Both the American and Chinese alligator are farmed intensively today, mostly within each species' respective native region. The Nile crocodile is found in ranches all over Africa, and the saltwater crocodile is farmed in Australia and other areas. The smaller caimans are generally not of enough market value to farm, though captive breeding of

5406-455: The adenovirus genome can occur. A terminal protein that is covalently bound to the 5' end of the adenovirus genome acts as a primer for replication. The viral DNA polymerase then uses a strand displacement mechanism, as opposed to the conventional Okazaki fragments used in mammalian DNA replication, to replicate the genome. The late phase of the adenovirus lifecycle is focused on producing sufficient quantities of structural protein to pack all

5508-423: The adenovirus. This co-receptor molecule is αV integrin . Binding to αV integrin results in endocytosis of the virus particle via clathrin-coated pits. Attachment to αV integrin stimulates cell signaling and thus induces actin polymerization, which facilitates clathrin-mediated endocytosis, and results in virion's entry into the host cell within an endosome . Once the virus has successfully gained entry into

5610-550: The animals' immune system, and puts them at risk of various illnesses. Another concern is for the cleanliness of the water in enclosures. Many alligator farms in the United States have experienced property damage from Sus scrofa (feral swine). Between 2001 and 2003, West Nile virus (WNV) infected and caused deaths resulting in economic loss in American alligators in Georgia , Florida , Louisiana , and Idaho . The disease

5712-548: The arm or elbow instead of the hand, to avoid sharing cups and eating utensils, and to refrain from kissing others. Chlorination of swimming pools can prevent outbreaks of conjunctivitis caused by adenovirus. Diagnosis is from symptoms and history. Tests are only necessary in very serious cases. Tests include blood tests, eyes, nose or throat swabs, stool sample tests, and chest x-rays. In the laboratory, adenovirus can be identified with antigen detection, polymerase chain reaction (PCR), virus isolation and serology. Even if adenovirus

5814-458: The beginning of the Holocene 11,700 years ago, a warmer climate and increasing human populations led to small-scale animal and plant domestication and an increased supply of food. The appearance of the domestic dog in the archaeological record, at least 15,000 years ago, was followed by domestication of livestock and of crops such as wheat and barley , the invention of agriculture , and

5916-472: The binding of protein VI to the endsomal membrane leading to a severe membrane curvature that ultimately disrupts the endosome. These changes, as well as the toxic nature of the pentons, destroy the endosome, resulting in the movement of the virion into the cytoplasm. With the help of cellular microtubules , the virus is transported to the nuclear pore complex, whereby the adenovirus particle disassembles. Viral DNA

6018-478: The body and water. Adenoviruses are spread primarily via respiratory droplets, however they can also be spread by fecal routes and via aerosols ( airborne transmission ). Research into the molecular mechanisms underlying adenoviral transmission provide empirical evidence in support of the hypothesis that coxsackievirus/adenovirus receptors (CARs) are needed to transport adenoviruses into certain naive/progenitor cell types. Humans infected with adenoviruses display

6120-506: The case of the termites, the relationship is a fully obligate symbiosis on both sides. Domestication (not to be confused with the taming of an individual animal ), is from the Latin domesticus , 'belonging to the house'. The term remained loosely defined until the 21st century, when the American archaeologist Melinda A. Zeder defined it as a long-term relationship in which humans take over control and care of another organism to gain

6222-420: The cells. Nevertheless, they are reliant upon each other to successfully transform the host cell and form tumors . E1A is mostly intrinsically disordered protein and contains CR3 domain which is critical for transcriptional activation. DNA replication separates the early and late phases. Once the early genes have liberated adequate virus proteins, replication machinery, and replication substrates, replication of

SECTION 60

#1732790635120

6324-415: The cost of starting and managing the operation often outweighs the profits gained from products. Although the cost of operating an open cycle operation is comparable to closed cycle, the goal of an open cycle operation is the overall health of the species, rather than economic profit. Captive breeding and ranching operations provide more incentive to protect natural populations and are important contributors to

6426-666: The death of Jesse Gelsinger in 1999. To address this risk, the genome of the viral genes have been modified to remove some viral genes. One such modification is the gutless vector that removes almost all the viral genome. Adenovirus has been used for delivery of CRISPR/Cas9 gene editing systems, but high immune reactivity to viral infection has posed challenges in use for patients. Modified ( recombinant ) adenovirus vectors, including replication incompetent types, can deliver DNA coding for specific antigens . Adenovirus have been used to produce viral vector COVID-19 vaccines . "In four candidate COVID-19 vaccines... Ad5... serves as

6528-435: The developing world. To offset overhead costs and have a regular source of income, crocodilian facilities can add tourism; in this way alligator farming can assist native species and provide people with work. Alligator farming has minimal adverse effects on the environment, and has at least two positive direct effects on alligator conservation. Because the luxury goods industry has a reliable stream of product, illegal poaching

6630-509: The domestication of animals involved violence against animals and damage to the environment. This, in turn, he argues, corrupted human ethics and paved the way for "conquest, extermination, displacement, repression, coerced and enslaved servitude, gender subordination and sexual exploitation, and hunger." Domesticated ecosystems provide food, reduce predator and natural dangers, and promote commerce, but their creation has resulted in habitat alteration or loss, and multiple extinctions commencing in

6732-515: The domestication syndrome; it is predicted that domestic animals are less resistant to parasites than their wild relatives. Domesticated birds principally mean poultry , raised for meat and eggs: some Galliformes ( chicken , turkey , guineafowl ) and Anseriformes (waterfowl: ducks , geese , and swans ). Also widely domesticated are cagebirds such as songbirds and parrots ; these are kept both for pleasure and for use in research. The domestic pigeon has been used both for food and as

6834-447: The freshwater cnidarian Hydra for research into genetics and physiology. Few have a long history of domestication. Most are used for food or other products such as shellac and cochineal . The phyla involved are Cnidaria , Platyhelminthes (for biological pest control ), Annelida , Mollusca , Arthropoda (marine crustaceans as well as insects and spiders), and Echinodermata . While many marine mollusks are used for food, only

6936-451: The general population or on people with weakened immune systems. In the past, US military recruits were vaccinated against two serotypes of adenovirus, with a corresponding decrease in illnesses caused by those serotypes. That vaccine is no longer manufactured. The U.S. Army Medical Research and Materiel Command announced on 31 October 2011 that a new adenovirus vaccine, which replaces the older version that has been out of production for over

7038-417: The genetic material produced by DNA replication. Once the viral components have successfully been replicated, the virus is assembled into its protein shells and released from the cell as a result of virally induced cell lysis . Adenovirus is capable of multiplicity reactivation (MR) (Yamamoto and Shimojo, 1971). MR is the process by which two, or more, virus genomes containing lethal damage interact within

7140-810: The genome and the epigenome , enabling a rapid evolutionary response to artificial selection. Polyploidy increases the number of chromosomes, bringing new combinations of genes and alleles, which in turn enable further changes such as by chromosomal crossover . The microbiome , the collection of microorganisms inhabiting the surface and internal tissue of plants, is affected by domestication. This includes changes in microbial species composition and diversity. Plant lineage, including speciation , domestication, and breeding , have shaped plant endophytes ( phylosymbiosis ) in similar patterns as plant genes. Several species of fungi have been domesticated for use directly as food, or in fermentation to produce foods and drugs. The cultivated mushroom Agaricus bisporus

7242-759: The government's willingness to take care of crocodilian populations. Animals other than crocodilians may benefit from a similar application of sustainable and ethical farming. Ranching, wild harvesting, and captive breeding are the three ways to obtain crocodilians recognized by the Convention on International Trade in Endangered Species (CITES) and the Crocodile Specialist Group (CSG). Alligators can be raised in captivity on farms or on ranches. Alligator farms breed alligators, whereas ranches incubate and rear hatchlings collected from

7344-432: The group B human adenovirus serotypes and the coxsackievirus/adenovirus receptor (CAR) for all other serotypes. There are some reports suggesting MHC molecules and sialic acid residues functioning in this capacity as well. This is followed by a secondary interaction, where a motif in the penton base protein (see capsomere ) interacts with an integrin molecule. It is the co-receptor interaction that stimulates entry of

7446-465: The health of the wild population and are using captive rearing as a means to supplement the wild populations. Closed-cycle operations are primarily concerned with harvest. In closed cycle operations, adult females are kept in captivity, and the eggs they lay are collected, incubated artificially, hatched, and the juveniles are grown to a certain size and harvested. Closed cycle operations provide no incentive for conservation and are often unsuccessful because

7548-532: The homogenizing effect of gene flow from wild boars into pigs, and created domestication islands in the genome. The same process may apply to other domesticated animals. The 2023 parasite-mediated domestication hypothesis suggests that endoparasites such as helminths and protozoa could have mediated the domestication of mammals. Domestication involves taming, which has an endocrine component; and parasites can modify endocrine activity and microRNAs . Genes for resistance to parasites might be linked to those for

7650-404: The host cell, the endosome acidifies, which alters virus topology by causing capsid components to disband. The capsid is destabilized and protein VI, which is one of the capsid constituents (see Adenovirus genome ) is released from it. Protein VI contains an N-terminal amphiphatic alpha-helix, a helical domain that exhibits both hydrophobic and hydrophilic properties. This amphipathic helix enables

7752-465: The human body develops immunity to the vector itself, making subsequent booster shots difficult or impossible. In some cases, people have pre-existing immunity to Adenoviruses, making vector delivery ineffective. The use of Ad5 vaccines for COVID-19 worried researchers who had experience with two failed trials of an Ad5 vaccine, Phambili and STEP, due to the increased risk for uncircumcised male patients of contracting HIV-1 via unprotected anal sex. At

7854-561: The infected cell to form a viable virus genome. Such MR was demonstrated for adenovirus 12 after virions were irradiated with UV light and allowed to undergo multiple infection of host cells. In a review, numerous examples of MR in different viruses were described, and it was suggested that MR is a common form of sexual interaction that provides the survival advantage of recombinational repair of genome damages. Adenoviruses are unusually stable to chemical or physical agents and adverse pH conditions, allowing for prolonged survival outside of

7956-426: The initial episode of domestication of that animal or plant, whereas improvement traits are present only in a proportion of domesticates, though they may be fixed in individual breeds or regional populations . Certain animal species, and certain individuals within those species, make better candidates for domestication because of their behavioral characteristics: The beginnings of mammal domestication involved

8058-580: The leaf material to the fungi that they tend. Some of these fungi are not fully domesticated: the fungi farmed by Mycocepurus smithii constantly produce spores that are not useful to the ants, which eat fungal hyphae instead. The process of domestication by Atta ants, on the other hand, is complete; it took 30 million years. Some 330 fungus-growing termite species of the subfamily Macrotermitinae cultivate Termitomyces fungi to eat; domestication occurred exactly once, 25–40 mya . The fungi, described by Roger Heim in 1942, grow on 'combs' formed from

8160-585: The meat of Nile crocodiles in Zimbabwe, and Coccidia. There have been reports of crocodiles escaping from farms during flooding. In 2013, approximately 15,000 crocodiles were released into the Limpopo River from flood gates at the nearby Rakwena Crocodile Farm. A crocodilian farm in Louisiana (in reality, Jamaica) is featured in the 1973 James Bond film Live and Let Die . Tee Hee Johnson, one of

8262-554: The meat to be a curative food for colds and cancer prevention, although there is no scientific evidence to support this. Crocodile meat was eaten, albeit rarely and as an exotic dish, in Vietnamese cuisine , but it was taboo and off limits for Chinese. In Vietnam, skinning is performed on still living crocodiles. A common misconception is that crocodilians are an easy source of revenue and not difficult to care for in captivity; however, few crocodilian businesses are successful in

8364-437: The public and the crocodiles, while maintaining an aesthetically pleasing environment. This frequently depends on enclosures that can be easily cleaned without harming the animals. If closed to public viewing, facilities have fewer requirements and can have a more practical design. Alligators and crocodiles can be raised in captivity with "open cycle" or "closed cycle" methods. Open cycle refers to programs that are concerned with

8466-514: The relationship between them intensified, and humans' role in their survival and reproduction gradually led to formalized animal husbandry . Although the directed pathway for draft and riding animals proceeded from capture to taming, the other two pathways are not as goal-oriented, and archaeological records suggest that they took place over much longer time frames. Unlike other domestic species selected primarily for production-related traits, dogs were initially selected for their behaviors. The dog

8568-459: The small number of traits that made domestic species different from their wild ancestors. He was also the first to recognize the difference between conscious selective breeding in which humans directly select for desirable traits and unconscious selection, in which traits evolve as a by-product of natural selection or from selection on other traits. There is a difference between domestic and wild populations; some of these differences constitute

8670-424: The success of crocodilian populations. Welfare concerns include the threat of crocodilian diseases such as caiman pox, adenoviral Hepatitis , mycoplasmosis , and chlamydiosis . Crocodiles suffer from stress in confined spaces such as farms, leading to disease outbreaks. Most crocodilians keep a body temperature within 28 and 33 degrees Celsius. On farms, body temperatures can reach 36 degrees Celsius, which affects

8772-451: The supposed primitive state of harmony with nature in hunter-gatherer societies, and replacing it, possibly violently or by enslavement, with a social hierarchy as property and power emerged. The dialectal naturalist Murray Bookchin has argued that domestication of animals, in turn, meant the domestication of humanity, both parties being unavoidably altered by their relationship with each other. The sociologist David Nibert asserts that

8874-481: The termites' excreta, dominated by tough woody fragments. The termites and the fungi are both obligate symbionts in the relationship. Adenovirus Adenoviruses (members of the family Adenoviridae ) are medium-sized (90–100 nm ), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double-stranded DNA genome. Their name derives from their initial isolation from human adenoids in 1953. They have

8976-761: The time, it was concluded that heightened risk of HIV reception may be observed for any Ad5-based vector vaccine. In October 2020, these researchers wrote in The Lancet : "On the basis of these findings, we are concerned that use of an Ad5 vector for immunisation against SARS-CoV-2 could similarly increase the risk of HIV-1 acquisition among men who receive the vaccine." Vaccines using other technologies would not be affected, but Sputnik V , Convidecia and ImmunityBio's hAd5 would. Two studies found that Ad5-specific CD4 T cells are more susceptible to HIV infection than CD4 T cells specific to certain other vectors, such as Cytomegalovirus and Canarypox . By comparison,

9078-637: The transition of humans from foraging to farming in different places and times across the planet. For instance, small-scale trial cultivation of cereals began some 28,000 years ago at the Ohalo II site in Israel. In the Fertile Crescent 11,000–10,000 years ago, zooarchaeology indicates that goats, pigs, sheep, and taurine cattle were the first livestock to be domesticated. Two thousand years later, humped zebu cattle were domesticated in what

9180-778: The urinary bladder—a form of urinary tract infection —with blood in the urine). Most people recover from adenovirus infections by themselves, but people with immunodeficiency sometimes die of adenovirus infections, and—rarely—even previously healthy people can die of these infections. This may be because sometimes adenoviral infection can lead to cardiac disorders. For example, in one study, some cardiac samples of patients with dilated cardiomyopathy were positive for presence of adenovirus type 8. Adenoviruses are often transmitted by expectoration (e.g. aerosols), but they can also be transmitted by contact with an infected person, or by virus particles left on objects such as towels and faucet handles. Some people with adenovirus gastroenteritis may shed

9282-600: The villain's henchman, attempts to feed James Bond to the alligators and crocodiles. In the second season of The Amazing Race Australia , teams had to visit a Cuban alligator farm and feed a wheelbarrow full of chum to a pen of alligators along with capturing an alligator with a stick and rope in order to receive their next clue. Source: Domestication Domestication is a multi-generational mutualistic relationship in which an animal species, such as humans or leafcutter ants , takes over control and care of another species, such as sheep or fungi, to obtain from them

9384-444: The viral gene economy, adenoviruses accommodate genes on both strands of its dsDNA meaning that most of its genome is utilized for coding proteins. An interesting feature of this viral genome is that it has a terminal 55 kDa protein associated with each of the 5' ends of the linear dsDNA. These are used as primers in viral replication and ensure that the ends of the virus' linear genome are adequately replicated. Adenoviruses possess

9486-432: The virus in their stools for months after getting over the symptoms. The virus can be passed through water in swimming pools that are not sufficiently chlorinated. As with many other illnesses, good handwashing practice is one way to inhibit the person-to-person transmission of adenoviruses. Heat and bleach will kill adenoviruses on objects. There are no proven antiviral drugs to treat adenoviral infections, so treatment

9588-414: The wild or bred alligators on-site begin to appear. This was largely driven by diminishing stocks of wild alligators, which had been hunted nearly to extinction by that time. As the American alligator was placed under official protection in 1967 (under a law preceding the 1973 Endangered Species Act ), farming alligators for skins became the most viable option for producing leather. Mostly concentrated in

9690-427: The wild. Crocodiles can be housed in a number of ways depending on the goals of the rearing facility. Large areas of a lake or marsh can be enclosed for many individuals or a smaller area can be created for fewer individuals. Due to the size and lifespan of the animals, adult crocodiles need a substantial amount of space. Tourism can bring additional revenue to crocodile rearing facilities, but they must be made safe for

9792-408: The wild. The first animal to be domesticated by humans was the dog , as a commensal , at least 15,000 years ago. Other animals, including goats , sheep , and cows , were domesticated around 11,000 years ago. Among birds, the chicken was first domesticated in East Asia, seemingly for cockfighting, some 7,000 years ago. The horse came under domestication around 5,500 years ago in central Asia as

9894-427: The wild. Farms do collect eggs from the wild but they also keep breeding adults in their facilities to produce their own eggs whereas ranches do not. Farming and ranching operations typically return a certain percentage of juveniles to the wild at a size associated with a high survival rate, an approach that increases overall alligator survival rates from the low numbers of successful eggs and juveniles usually observed in

9996-500: Was domesticated long before other animals, becoming established across Eurasia before the end of the Late Pleistocene era, well before agriculture . The archaeological and genetic data suggest that long-term bidirectional gene flow between wild and domestic stocks – such as in donkeys , horses , New and Old World camelids, goats, sheep, and pigs – was common. Human selection for domestic traits likely counteracted

10098-532: Was gradual and geographically diffuse – happening in many small steps and spread over a wide area – on the evidence of both archaeology and genetics. It was a process of intermittent trial and error and often resulted in diverging traits and characteristics. Whereas domestication of animals impacted most on the genes that controlled behavior, that of plants impacted most on the genes that controlled morphology (seed size, plant architecture, dispersal mechanisms) and physiology (timing of germination or ripening), as in

10200-1237: Was initially used in a vaccine for dogs, but corneal edema was a common complication. Squirrel adenovirus (SqAdV) is reported to cause enteritis in red squirrels in Europe, while gray squirrels seem to be resistant. SqAdV is most closely related to the adenovirus of guinea pigs (GpAdV). Adenovirus in reptiles is poorly understood, but research is currently in progress. Adenoviruses are also known to cause respiratory infections in horses , cattle , pigs , sheep , and goats . Equine adenovirus 1 can also cause fatal disease in immunocompromised Arabian foals , involving pneumonia and destruction of pancreatic and salivary gland tissue. Tupaia adenovirus (TAV) (tree shrew adenovirus 1) has been isolated from tree shrews. Otarine adenovirus 1 has been isolated from sea lions ( Zalophus californianus ). The fowl adenoviruses are associated with many disease conditions in domestic fowl like inclusion body hepatitis , hydropericardium syndrome , Egg drop syndrome , Quail bronchitis , Gizzard erosions and many respiratory conditions. They have also been isolated from wild black kites (Milvus migrans). Titi monkey adenovirus

10302-428: Was isolated from a colony of monkeys. Currently there is a vaccine for adenovirus type 4 and 7 for US military personnel only. US military personnel are the recipients of this vaccine because they may be at a higher risk of infection. The vaccine contains a live virus, which may be shed in stool and lead to transmission. The vaccine is not approved for use outside of the military, as it has not been tested in studied in

10404-557: Was triggered by the climatic and environmental changes that occurred after the peak of the Last Glacial Maximum and which continue to this present day. These changes made obtaining food by hunting and gathering difficult. The first animal to be domesticated was the dog at least 15,000 years ago. The Younger Dryas 12,900 years ago was a period of intense cold and aridity that put pressure on humans to intensify their foraging strategies but did not favour agriculture. By

#119880