Misplaced Pages

#190809

126-479: BIO holds its annual international conference each year in the United States . This conference provides networking, business development and partnering activities that are essential to the biotechnology industry, in which developing products take considerable time and resources and regulatory risks are high. In 2021, BIO shifted its in-person meetings to virtual, due to restrictions and difficulties arising from

252-416: A Polaroid pack film , and on his second appearance, he used a Holga with a Polaroid back, a Japanese-only model. The book Collector's Guide to Instant Cameras has a dedication to Fraser. He is also an accomplished amateur archer. In 2018, Fraser revealed the physical demands of the stunts and maneuvers he performed in his action and comedy roles eventually required him to undergo several surgeries over

378-577: A lower house based on population; and the Senate , an upper house based on equal representation for each state. Federalism provides substantial autonomy to the 50 states, while the country's political culture promotes liberty , equality , individualism , personal autonomy , and limited government . One of the world's most developed countries , the United States has had the largest nominal GDP since about 1890 and accounted for over 15% of

504-580: A " Special Relationship " with the United Kingdom and strong ties with Canada , Australia , New Zealand , the Philippines , Japan , South Korea , Israel , and several European Union countries ( France , Italy , Germany , Spain , and Poland ). The U.S. works closely with its NATO allies on military and national security issues, and with countries in the Americas through

630-596: A 2018 interview with GQ , Fraser revealed that his oldest son is on the autism spectrum . When their home in Beverly Hills, California sold in April 2007 for $ 3 million, Fraser's publicist announced in December 2007 that the couple had decided to divorce. Fraser was ordered to pay a monthly alimony sum of $ 50,000 for a period of ten years or until remarriage of Smith, whichever occurred first, in addition to

756-463: A Jewish star quarterback confronting embedded anti-semitism in private prep school society. Between 1994 and 1996, he starred in several box office failures such as With Honors (1994) with Joe Pesci , Airheads (1994) with Steve Buscemi & Adam Sandler , The Passion of Darkly Noon (1995), Mrs. Winterbourne (1996) and The Twilight of the Golds (1997). He also had a small part in

882-750: A Montessori school in Detroit and the Sacred Heart School in Bellevue, Washington . He then attended Upper Canada College , a private boarding school in Toronto , from which he graduated in 1987. While on vacation in London, England , in the 1970s, he attended his first professional theatre show, Oliver! , in the West End , which began his interest in acting. He also joined the chorus of

1008-542: A coordinated, continent-wide military effort. Finally, deteriorating relations between the British military establishment and the colonists, relations that were already less than positive, set the stage for further distrust and dislike of British troops. Following their victory in the French and Indian War, Britain began to assert greater control over local colonial affairs, resulting in colonial political resistance ; one of

1134-534: A decentralized government that operated until 1789. After the British surrender at the siege of Yorktown in 1781 American sovereignty was internationally recognized by the Treaty of Paris (1783), through which the U.S. gained territory stretching west to the Mississippi River, north to present-day Canada, and south to Spanish Florida . The Northwest Ordinance (1787) established the precedent by which

1260-407: A few prominent industrialists , largely by their formation of trusts and monopolies to prevent competition. Tycoons led the nation's expansion in the railroad , petroleum , and steel industries. The United States emerged as a pioneer of the automotive industry . These changes were accompanied by significant increases in economic inequality , slum conditions , and social unrest , creating

1386-638: A founding member of the World Bank , Organization of American States , NATO , and the United Nations , as well as a permanent member of the UN Security Council . The first documented use of the phrase "United States of America" is a letter from January 2, 1776. Stephen Moylan , a Continental Army aide to General George Washington , wrote to Joseph Reed , Washington's aide-de-camp , seeking to go "with full and ample powers from

SECTION 10

#1732773398191

1512-429: A heterosexual gardener (played by Fraser) and a homosexual, tortured and ailing filmmaker (played by McKellen). He achieved his biggest commercial success when he portrayed the lead adventurer Rick O'Connell in the fantasy adventure film The Mummy (1999) and its sequel The Mummy Returns (2001). The Mummy established him as one of the biggest film stars of 1990s. In between these successes, he also starred in

1638-643: A high-school musical production of Oklahoma! . Fraser graduated from Seattle's Cornish College of the Arts in 1990. He began acting at a small acting college in New York City . Fraser planned on studying toward a Master of Fine Arts in Acting from Southern Methodist University , but stopped in Hollywood on the way and decided to remain there to work in film. In 1991, Fraser made his film debut with

1764-598: A period of heightened, overt racism following Reconstruction, a time often called the nadir of American race relations . A series of Supreme Court decisions, including Plessy v. Ferguson , emptied the Fourteenth and Fifteenth Amendments of their force, allowing Jim Crow laws in the South to remain unchecked, sundown towns in the Midwest, and segregation in communities across the country , which would be reinforced by

1890-695: A period of seven years, including a partial knee replacement , a laminectomy , and vocal cord surgery. In 2018, Fraser said that he had been sexually assaulted by Philip Berk , the then-president of the Hollywood Foreign Press Association (HFPA), the nonprofit organization that votes for the Golden Globe Awards , at a luncheon in 2003. Berk has described Fraser's account as a "total fabrication", but in his 2014 memoir, he admitted to having groped Fraser "in jest". The alleged assault, his subsequent divorce, and

2016-488: A prominent leader in the early 1960s. The Great Society plan of President Lyndon Johnson 's administration resulted in groundbreaking and broad-reaching laws, policies and a constitutional amendment to counteract some of the worst effects of lingering institutional racism . The counterculture movement in the U.S. brought significant social changes, including the liberalization of attitudes toward recreational drug use and sexuality . It also encouraged open defiance of

2142-492: A representative voice for the smaller companies among BIO's membership. After Congressman Greenwood's 15 years of service, the BIO board announced scientist and former FDA regulator Michelle McMurry-Heath would become president and CEO as of 1 June 2020. McMurry-Heath was placed on leave sometime prior to October 6, 2022, reportedly as a result of disagreements with a small but influential group of board members who wanted

2268-526: A sense of manifest destiny . The Missouri Compromise attempted to balance the desire of northern states to prevent the expansion of slavery into new territories with that of southern states to extend it, admitting Missouri as a slave state and Maine as a free state. It further prohibited slavery in all other lands of the Louisiana Purchase north of the 36°30′ parallel . As Americans expanded further into land inhabited by Native Americans,

2394-614: A sense of American identity as well. Men who otherwise never left their own colony now traveled across the continent to fight alongside men from decidedly different backgrounds but who were no less "American". British officers trained American officers for battle, most notably George Washington ; these officers would lend their skills and expertise to the colonists' cause during the American Revolutionary War to come. In addition, colonial legislatures and officials found it necessary to cooperate intensively in pursuit of

2520-574: A small role as a seaman headed to Vietnam in Dogfight . He got his first leading film role alongside Sean Astin and Pauly Shore in the 1992 comedy film Encino Man , where he played a frozen pre-historic caveman who is thawed out in the present day. The film was a moderate box office success and has gained a cult following. That same year he starred in School Ties with fellow rising actors Matt Damon , Ben Affleck , and Chris O'Donnell as

2646-576: A status solidified after its involvement in World War I . After Japan 's attack on Pearl Harbor in December 1941, the U.S. entered World War II . Its aftermath left the U.S. and the Soviet Union as the world's two superpowers and led to the Cold War , during which both countries struggled for ideological dominance and international influence . Following the Soviet Union's collapse and

SECTION 20

#1732773398191

2772-401: A year). Juvenile correctional facilities are operated by local or state governments and serve as longer-term placements for any minor adjudicated as delinquent and ordered by a judge to be confined. As of January 2023, the United States has the sixth-highest per capita incarceration rate in the world—531 people per 100,000 inhabitants—and the largest prison and jail population in

2898-580: Is a country primarily located in North America . It is a federal union of 50 states and a federal capital district, Washington, D.C. The 48 contiguous states border Canada to the north and Mexico to the south, with the states of Alaska to the northwest and the archipelagic Hawaii in the Pacific Ocean . The United States also asserts sovereignty over five major island territories and various uninhabited islands . The country has

3024-731: Is an American-Canadian actor. Fraser had his breakthrough in 1992 with the comedy Encino Man and the drama School Ties . He gained further prominence for his starring roles in the comedies With Honors (1994) and George of the Jungle (1997) and emerged as a star playing Rick O'Connell in The Mummy trilogy (1999–2008). He took on dramatic roles in Gods and Monsters (1998), The Quiet American (2002), and Crash (2004), and further fantasy roles in Bedazzled (2000) and Journey to

3150-591: Is believed to be the first widespread culture in the Americas. Over time, indigenous North American cultures grew increasingly sophisticated, and some, such as the Mississippian culture , developed agriculture , architecture , and complex societies . In the post-archaic period , the Mississippian cultures were located in the midwestern , eastern , and southern regions, and the Algonquian in

3276-498: Is known as the presidential system , in contrast to the parliamentary system , where the executive is part of the legislative body. Many countries around the world imitated this aspect of the 1789 Constitution of the United States , especially in the Americas. The Constitution is silent on political parties. However, they developed independently in the 18th century with the Federalist and Anti-Federalist parties. Since then,

3402-438: Is now the United States experienced conflicts with Native Americans, they also engaged in trade, exchanging European tools for food and animal pelts. Relations ranged from close cooperation to warfare and massacres. The colonial authorities often pursued policies that forced Native Americans to adopt European lifestyles, including conversion to Christianity. Along the eastern seaboard, settlers trafficked African slaves through

3528-552: Is the federal agency charged with addressing most environmental-related issues . The idea of wilderness has shaped the management of public lands since 1964, with the Wilderness Act . The Endangered Species Act of 1973 provides a way to protect threatened and endangered species and their habitats. The United States Fish and Wildlife Service implements and enforces the Act. In 2024, the U.S. ranked 34th among 180 countries in

3654-603: The Allies of World War I , helping to turn the tide against the Central Powers . In 1920, a constitutional amendment granted nationwide women's suffrage . During the 1920s and '30s, radio for mass communication and the invention of early television transformed communications nationwide. The Wall Street Crash of 1929 triggered the Great Depression , which President Franklin D. Roosevelt responded to with

3780-553: The Atlantic slave trade . The original Thirteen Colonies that would later found the United States were administered as possessions of Great Britain , and had local governments with elections open to most white male property owners . The colonial population grew rapidly, eclipsing Native American populations; by the 1770s, the natural increase of the population was such that only a small minority of Americans had been born overseas. The colonies' distance from Britain allowed for

3906-549: The Environmental Performance Index . The country joined the Paris Agreement on climate change in 2016 and has many other environmental commitments. The United States is a federal republic of 50 states and a separate federal capital district, Washington, D.C. It also asserts sovereignty over five unincorporated territories and several uninhabited island possessions . The U.S. is

Biotechnology Innovation Organization - Misplaced Pages Continue

4032-500: The Federal Bureau of Investigation (FBI) and the U.S. Marshals Service have national jurisdiction and specialized duties, such as protecting civil rights , national security and enforcing U.S. federal courts ' rulings and federal laws. State courts conduct most civil and criminal trials, and federal courts handle designated crimes and appeals of state court decisions . There is no unified "criminal justice system" in

4158-720: The Great Lakes , Mississippi River and Gulf of Mexico . British colonization of the East Coast began with the Virginia Colony (1607) and Plymouth Colony (1620). The Mayflower Compact and the Fundamental Orders of Connecticut established precedents for representative self-governance and constitutionalism that would develop throughout the American colonies. While European settlers in what

4284-719: The Great Lakes region and along the Eastern Seaboard , while the Hohokam culture and Ancestral Puebloans inhabited the southwest . Native population estimates of what is now the United States before the arrival of European immigrants range from around 500,000 to nearly 10 million. Christopher Columbus began exploring the Caribbean for Spain in 1492, leading to Spanish-speaking settlements and missions from Puerto Rico and Florida to New Mexico and California . France established its own settlements along

4410-596: The Midwest . At the same time, about one million French Canadians migrated from Quebec to New England . During the Great Migration , millions of African Americans left the rural South for urban areas in the North. Alaska was purchased from Russia in 1867. The Compromise of 1877 effectively ended Reconstruction and white supremacists took local control of Southern politics . African Americans endured

4536-688: The National Park Service and other agencies. About 28% of the country's land is publicly owned and federally managed, primarily in the Western States . Most of this land is protected , though some is leased for commercial use, and less than one percent is used for military purposes. Environmental issues in the United States include debates on non-renewable resources and nuclear energy , air and water pollution , biodiversity , logging and deforestation , and climate change . The U.S. Environmental Protection Agency (EPA)

4662-596: The New Deal , a series of sweeping programs and public works projects combined with financial reforms and regulations . All were intended to protect against future economic depressions. Initially neutral during World War II , the U.S. began supplying war materiel to the Allies of World War II in March 1941 and entered the war in December after the Empire of Japan 's attack on Pearl Harbor . The U.S. developed

4788-778: The Organization of American States and the United States–Mexico–Canada Free Trade Agreement . In South America, Colombia is traditionally considered to be the closest ally of the United States. The U.S. exercises full international defense authority and responsibility for Micronesia , the Marshall Islands , and Palau through the Compact of Free Association . It has increasingly conducted strategic cooperation with India , but its ties with China have steadily deteriorated. Since 2014,

4914-648: The Pentium microprocessor in accordance with Moore's law , rechargeable lithium-ion batteries , the first gene therapy trial, and cloning either emerged in the U.S. or were improved upon there. The Human Genome Project was formally launched in 1990, while Nasdaq became the first stock market in the United States to trade online in 1998. In the Gulf War of 1991, an American-led international coalition of states expelled an Iraqi invasion force that had occupied neighboring Kuwait . The September 11 attacks on

5040-711: The Showtime drama The Affair (2016–2017), the FX series Trust (2018), and the Max series Doom Patrol (2019–2023). His film career was revitalized by roles in Steven Soderbergh 's No Sudden Move (2021) and Darren Aronofsky 's The Whale (2022). Fraser's starring role as an obese gay man in the latter earned him critical acclaim and numerous accolades, including the Academy Award for Best Actor ,

5166-591: The Spanish–American War . (The Philippines was granted full independence from the U.S. on July 4, 1946, following World War II. Puerto Rico and Guam have remained U.S. territories.) American Samoa was acquired by the United States in 1900 after the Second Samoan Civil War . The U.S. Virgin Islands were purchased from Denmark in 1917. The United States entered World War I alongside

Biotechnology Innovation Organization - Misplaced Pages Continue

5292-648: The cotton gin made the institution increasingly profitable for Southern elites . This sectional conflict regarding slavery culminated in the American Civil War (1861–1865). Eleven slave states seceded and formed the Confederate States of America , while the other states remained in the Union . War broke out in April 1861 after the Confederates bombarded Fort Sumter . After

5418-523: The end of the Cold War in 1991, the U.S. emerged as the world's sole superpower , wielding significant geopolitical influence globally . The U.S. national government is a presidential constitutional federal republic and liberal democracy with three separate branches : legislative , executive , and judicial . It has a bicameral national legislature composed of the House of Representatives ,

5544-537: The fall of communism and the collapse of the Soviet Union , which marked the end of the Cold War and left the United States as the world's sole superpower . The 1990s saw the longest recorded economic expansion in American history , a dramatic decline in U.S. crime rates , and advances in technology . Throughout this decade, technological innovations such as the World Wide Web , the evolution of

5670-400: The global economy in 2023. It possesses by far the largest amount of wealth of any country and has the highest disposable household income per capita among OECD countries. The U.S. ranks among the world's highest in economic competitiveness , productivity , innovation , human rights , and higher education . Its hard power and cultural influence have a global reach. The U.S. is

5796-423: The $ 25,000 monthly payment for child support. In early 2011, Fraser petitioned the courts for a reduction of his alimony payments, asserting that he was unable to meet the annual obligation of $ 600,000; he did not contest the child support payments. In late 2011, Smith accused Fraser of fraud by hiding financial assets and not disclosing film contracts for Extraordinary Measures and Furry Vengeance . In 2014,

5922-813: The 1775 Battles of Lexington and Concord , igniting the American Revolutionary War . At the Second Continental Congress , the colonies appointed George Washington commander-in-chief of the Continental Army , and created a committee that named Thomas Jefferson to draft the Declaration of Independence . Two days after passing the Lee Resolution to create an independent nation the Declaration

6048-420: The 1995 film Now and Then . He made cameo appearances in the Pauly Shore films Son in Law (1993) and In the Army Now (1994), reprising his Encino Man role. Fraser performed at his first theatre production in 1995 at the Geffen Playhouse , taking on the role of Victor in John Patrick Shanley 's Four Dogs and a Bone . He had his first major box office success with the 1997 comedy film George of

6174-466: The 2010s, political polarization in the country increased between liberal and conservative factions. This polarization was capitalized upon in the January 2021 Capitol attack , when a mob of insurrectionists entered the U.S. Capitol and sought to prevent the peaceful transfer of power in an attempted self-coup d'état . The United States is the world's third-largest country by total area behind Russia and Canada. The 48 contiguous states and

6300-495: The 2022 Venice Film Festival, and Fraser thanked Moore during his acceptance speech for the Oscar for Best Actor during the 95th Academy Awards . As of February 2018 , Fraser lives in Bedford , New York . Fraser speaks French and serves on the board of directors for FilmAid International . He is an accomplished amateur photographer and has used several instant cameras in movies and on TV shows, most notably on his guest roles on Scrubs . In his first appearance, he used

6426-426: The American West have an alpine climate . The climate is arid in the Southwest, Mediterranean in coastal California , and oceanic in coastal Oregon , Washington , and southern Alaska . Most of Alaska is subarctic or polar . Hawaii , the southern tip of Florida and U.S. territories in the Caribbean and Pacific are tropical . States bordering the Gulf of Mexico are prone to hurricanes, and most of

SECTION 50

#1732773398191

6552-414: The Biotechnology Innovation Organization (BIO) and the Science History Institute (formerly the Chemical Heritage Foundation), recognizes individuals who have made significant contributions to the development of biotechnology through discovery, innovation, and public understanding. United States The United States of America ( USA ), commonly known as the United States ( U.S. ) or America ,

6678-459: The COVID-19 pandemic. In 2018, BIO spent $ 9.87 million on lobbying the government of the United States. Past issues that BIO has lobbied on included the amending the Internal Revenue Code to provide an exception from the passive loss rules for investments in high-technology research small business pass-through entities , to include vaccines against seasonal influenza within the definition of taxable vaccines, and to extend, expand, and improve

6804-400: The Center of the Earth (2008). Fraser's film work slowed from the late 2000s to mid-2010s due to poor box office performances, and various health and personal issues, including the fallout from a sexual assault committed against him in 2003 by Philip Berk , the then-president of the Hollywood Foreign Press Association . In addition to films, Fraser branched into television with roles in

6930-455: The Center of the Earth . Filming was delayed and late in 2011, Fraser sued the producer Todd Moyer for promised wages. Moyer later countersued for assault, which Fraser dismissed as [Moyer's] desperate attempt to avoid paying his debt. In 2013, he played an Elvis Presley impersonator in the ensemble black comedy Pawn Shop Chronicles . In 2016, Fraser replaced Ray Liotta in the Bollywood thriller Line of Descent . Fraser later joined

7056-683: The Coalition of Small Business Innovators to lobby the U.S. government to modernize the U.S. tax code "to recognize and promote small business innovation as fundamental to the long-term growth of the U.S. economy". It is a member of The Alliance to Feed the Future, an umbrella network, the mission of which is to "raise awareness and improve understanding of the benefits & necessity of modern food production and technology in order to meet global demand". The "Right Mix Matters" campaign launched in 2019 targets diversity within biopharmaceutical company leadership, including ongoing assessment of diversity measures (gender, race, ethnicity, sexual orientation) and

7182-420: The Declaration of Independence on July 4, 1776. The term "United States" and the initialism "U.S.", used as nouns or as adjectives in English, are common short names for the country. The initialism "USA", a noun, is also common. "United States" and "U.S." are the established terms throughout the U.S. federal government , with prescribed rules. In English, the term "America" rarely refers to topics unrelated to

7308-410: The District Attorney of Los Angeles. He has also made guest appearances on the television shows Scrubs , King of the Hill , and The Simpsons . In March 2006, he was inducted into Canada's Walk of Fame , the first American-born actor to receive the honor. However, as of 2022, he does not have a star on the Hollywood Walk of Fame . After a six-year hiatus in the franchise, Fraser returned for

7434-404: The District of Columbia occupy a combined area of 3,119,885 square miles (8,080,470 km ). The coastal plain of the Atlantic seaboard gives way to inland forests and rolling hills in the Piedmont plateau region. The Appalachian Mountains and the Adirondack massif separate the East Coast from the Great Lakes and the grasslands of the Midwest . The Mississippi River System ,

7560-458: The Elder concluded that major military resources needed to be devoted to North America to win the war against France. For the first time, the continent became one of the main theaters of what could be termed a " world war ". The British colonies' position as an integral part of the British Empire became more apparent during the war, with British military and civilian officials becoming a more significant presence in American life. The war increased

7686-469: The End of the Night . "A light bulb went off, and I was like, 'Oh, that guy can do it'", he said. The film premiered at the Venice International Film Festival in September 2022. Fraser spoke on preparing for the role with The New York Times stating, "The Obesity Action Coalition gave me access to many people, so I could ask them their story on Zoom calls. I talked to maybe eight or 10 people — some bedridden, some perfectly mobile." Fraser's performance

SECTION 60

#1732773398191

7812-465: The January 1863 Emancipation Proclamation , many freed slaves joined the Union army . The war began to turn in the Union's favor following the 1863 Siege of Vicksburg and Battle of Gettysburg , and the Confederacy surrendered in 1865 after the Union's victory in the Battle of Appomattox Court House . The Reconstruction era followed the war. After the assassination of President Abraham Lincoln , Reconstruction Amendments were passed to protect

7938-402: The Jungle which was based on the animated series of the same title created by Jay Ward . He received critical acclaim for his dramatic role in 1998's Gods and Monsters , which was based on the life of James Whale ( Ian McKellen ), who directed Frankenstein . The film was written and directed by Bill Condon , and follows the loss of creativity, ambiguous sexuality and the bond between

8064-476: The Rocky Mountains, the Yellowstone Caldera , is the continent's largest volcanic feature. In 2021, the United States had 8% of global permanent meadows and pastures and 10% of cropland. With its large size and geographic variety, the United States includes most climate types. East of the 100th meridian , the climate ranges from humid continental in the north to humid subtropical in the south. The western Great Plains are semi-arid . Many mountainous areas of

8190-451: The U.S. has become a key ally of Ukraine ; it has also provided the country with significant military equipment and other support in response to Russia's 2022 invasion . The president is the commander-in-chief of the United States Armed Forces and appoints its leaders, the secretary of defense and the Joint Chiefs of Staff . The Department of Defense , which is headquartered at the Pentagon near Washington, D.C., administers five of

8316-661: The U.S. territories." Despite disparate systems of confinement, four main institutions dominate: federal prisons , state prisons , local jails, and juvenile correctional facilities . Federal prisons are run by the Federal Bureau of Prisons and hold people who have been convicted of federal crimes, including pretrial detainees. State prisons, run by the official department of correction of each state, hold sentenced people serving prison time (usually longer than one year) for felony offenses. Local jails are county or municipal facilities that incarcerate defendants prior to trial; they also hold those serving short sentences (typically under

8442-416: The United States and the peaceful transfer of power , respectively. The Louisiana Purchase of 1803 from France nearly doubled the territory of the United States. Lingering issues with Britain remained , leading to the War of 1812 , which was fought to a draw. Spain ceded Florida and its Gulf Coast territory in 1819. In the late 18th century, American settlers began to expand westward , many with

8568-541: The United States entered the Cold War, where geopolitical tensions between the U.S. and the Soviet Union led the two countries to dominate world affairs . The U.S. utilized the policy of containment to limit the USSR's sphere of influence, and prevailed in the Space Race , which culminated with the first crewed Moon landing in 1969. Domestically, the U.S. experienced economic growth , urbanization , and population growth following World War II . The civil rights movement emerged, with Martin Luther King Jr. becoming

8694-495: The United States has operated as a de facto two-party system , though the parties in that system have been different at different times. The two main national parties are presently the Democratic and the Republican . The former is perceived as relatively liberal in its political platform while the latter is perceived as relatively conservative . In the American federal system , sovereign powers are shared between two levels of elected government: national and state. People in

8820-402: The United States in 2001 by the pan-Islamist militant organization al-Qaeda led to the war on terror , and subsequent military interventions in Afghanistan and Iraq . The cultural impact of the attacks was profound and long-lasting. The U.S. housing bubble culminated in 2007 with the Great Recession , the largest economic contraction since the Great Depression. Coming to a head in

8946-415: The United States of America to Spain" to seek assistance in the Revolutionary War effort. The first known public usage is an anonymous essay published in the Williamsburg newspaper, The Virginia Gazette , on April 6, 1776. By June 1776, the "United States of America" appeared in the Articles of Confederation and the Declaration of Independence . The Second Continental Congress adopted

9072-593: The United States, despite the usage of "the Americas " as the totality of North and South America. "The States" is an established colloquial shortening of the name, used particularly from abroad; "stateside" is the corresponding adjective or adverb. The first inhabitants of North America migrated from Siberia across the Bering land bridge about 12,000 years ago; the Clovis culture , which appeared around 11,000 BC,

9198-624: The United States, except Iran , North Korea , and Bhutan . Though Taiwan does not have formal diplomatic relations with the U.S., it maintains close unofficial relations. The United States regularly supplies Taiwan with military equipment to deter potential Chinese aggression. Its geopolitical attention also turned to the Indo-Pacific when the United States joined the Quadrilateral Security Dialogue with Australia, India, and Japan. The United States has

9324-509: The United States. The American prison system is largely heterogenous, with thousands of relatively independent systems operating across federal, state, local, and tribal levels. In 2023, "these systems [held] almost 2 million people in 1,566 state prisons, 98 federal prisons, 3,116 local jails, 1,323 juvenile correctional facilities, 181 immigration detention facilities, and 80 Indian country jails, as well as in military prisons , civil commitment centers, state psychiatric hospitals, and prisons in

9450-523: The box office bombs Dudley Do-Right (1999) (which was based on another Jay Ward animated series) and the stop-motion/live-action fantasy comedy Monkeybone (2001); though he did have moderate success with the romantic comedy Blast from the Past (1999) and the fantasy comedy Bedazzled (2000), a remake of the 1967 British film of the same name . He lent his voice for the unreleased animated film Big Bug Man , with Marlon Brando . In 2001, Fraser

9576-457: The contiguous United States are in the State of California, about 84 miles (135 km) apart. At an elevation of 20,310 feet (6,190.5 m), Alaska's Denali is the highest peak in the country and continent. Active volcanoes are common throughout Alaska's Alexander and Aleutian Islands , and Hawaii consists of volcanic islands. The supervolcano underlying Yellowstone National Park in

9702-556: The country's GDP. The U.S. has 42% of the world's nuclear weapons —the second-largest share after Russia. The United States has the third-largest combined armed forces in the world, behind the Chinese People's Liberation Army and Indian Armed Forces . The military operates about 800 bases and facilities abroad, and maintains deployments greater than 100 active duty personnel in 25 foreign countries. State defense forces (SDFs) are military units that operate under

9828-469: The country's territory would expand with the admission of new states , rather than the expansion of existing states. The U.S. Constitution was drafted at the 1787 Constitutional Convention to overcome the limitations of the Articles. It went into effect in 1789, creating a federal republic governed by three separate branches that together ensured a system of checks and balances . George Washington

9954-407: The court ruled against Fraser's request for a reduction in alimony and against Smith's allegation of fraud. Both parents were credited for being actively engaged in the lives of their sons. Smith has since made the transition from acting to writing books and real estate. Fraser has been in a relationship with makeup artist Jeanne Moore since September 2022. The couple made their red carpet debut at

10080-466: The death of his mother launched Fraser into a depression that, combined with his health problems, led to a break in his career. Several publications and social media users interpreted that Fraser was blacklisted from Hollywood because of his accusation against Berk. In the 2018 GQ piece where Fraser first publicly made the allegation, he said, "The phone does stop ringing in your career, and you start asking yourself why. There's many reasons, but

10206-713: The development of self-governance, and the First Great Awakening , a series of Christian revivals , fueled colonial interest in religious liberty . For a century, the American colonists had been providing their own troops and materiel in conflicts with indigenous peoples allied with Britain's colonial rivals , especially France, and the Americans had begun to develop a sense of self-defense and self-reliance separate from Britain. The French and Indian War (1754–1763) took on new significance for all North American colonists after Parliament under William Pitt

10332-414: The dispossession of native inhabitants . As more states were admitted , a North–South division over slavery led to the secession of the Confederate States of America , which fought states remaining in the Union in the 1861–1865 American Civil War . With the victory and preservation of the United States, slavery was abolished nationally . By 1900, the country had established itself as a great power ,

10458-580: The environment for labor unions to begin to flourish . This period eventually ended with the advent of the Progressive Era , which was characterized by significant reforms. Pro-American elements in Hawaii overthrew the Hawaiian monarchy ; the islands were annexed in 1898. That same year, Puerto Rico , the Philippines , and Guam were ceded to the U.S. by Spain after the latter's defeat in

10584-541: The federal government often applied policies of Indian removal or assimilation . The Trail of Tears (1830–1850) was a U.S. government policy that forcibly removed and displaced most Native Americans living east of the Mississippi River to lands far to the west. These and earlier organized displacements prompted a long series of American Indian Wars west of the Mississippi. The Republic of Texas

10710-584: The first Canadian to do so. Fraser was born on December 3, 1968, in Indianapolis, Indiana , to Canadian parents Carol Mary ( née Généreux; 1937–2016) and Peter Fraser. He is the youngest of four siblings; his brothers are Kevin, Sean, and Regan. His mother was a sales counselor, and his father was a former journalist who worked as a Canadian foreign service officer for the Government Office of Tourism. His maternal uncle, George Genereux ,

10836-606: The first nuclear weapons and used them against the Japanese cities of Hiroshima and Nagasaki in August 1945, ending the war. The United States was one of the " Four Policemen " who met to plan the post-war world , alongside the United Kingdom , Soviet Union , and China . The U.S. emerged relatively unscathed from the war, with even greater economic power and international political influence . After World War II,

10962-665: The first settlement of the Thirteen Colonies in Virginia in 1607. Clashes with the British Crown over taxation and political representation sparked the American Revolution , with the Second Continental Congress formally declaring independence on July 4, 1776. Following its victory in the 1775–1783 Revolutionary War , the country continued to expand westward across North America , resulting in

11088-463: The integration of Army National Guard units and personnel into the U.S. Army and (since 1947) the U.S. Air Force. There are about 18,000 U.S. police agencies from local to national level in the United States. Law in the United States is mainly enforced by local police departments and sheriff departments in their municipal or county jurisdictions. The state police departments have authority in their respective state , and federal agencies such as

11214-482: The military draft (leading to the end of conscription in 1973) and wide opposition to U.S. intervention in Vietnam (with the U.S. totally withdrawing in 1975). A societal shift in the roles of women was significantly responsible for the large increase in female paid labor participation during the 1970s, and by 1985 the majority of American women aged 16 and older were employed. The late 1980s and early 1990s saw

11340-612: The most attractive to the population are the most vulnerable. The U.S. is one of 17 megadiverse countries containing large numbers of endemic species : about 17,000 species of vascular plants occur in the contiguous United States and Alaska, and over 1,800 species of flowering plants are found in Hawaii, few of which occur on the mainland. The United States is home to 428 mammal species, 784 birds, 311 reptiles, 295 amphibians , and around 91,000 insect species. There are 63 national parks , and hundreds of other federally managed parks, forests, and wilderness areas , managed by

11466-662: The most violent, the California genocide of thousands of Native inhabitants, lasted into the early 1870s, just as additional western territories and states were created. During the colonial period, slavery had been legal in the American colonies , though the practice began to be significantly questioned during the American Revolution. States in the North enacted abolition laws , though support for slavery strengthened in Southern states , as inventions such as

11592-436: The organization to use its clout to advance social issues not directly connected to its industry interests. Additionally, questions had been raised by some board members about her performance and management style. Heath resigned effective October 11, 2022, with GlycoMimetics co-founder and former CEO Rachel King tapped to serve as interim CEO of the organization. In 2023, John Crowley , Executive Chairman of Amicus Therapeutics ,

11718-553: The organization. Since 2018, Fraser has been a celebrity judge on the Dancing Stars of Greenwich annual charity gala which raises money for the non-profit organization Abilis, a local charity which supports more than 800 individuals and their families with disabilities in Fairfield County, Connecticut . His former wife, Afton Smith, also takes part in the dance competition. In 2022, Smith and Fraser received

11844-408: The policy of redlining later adopted by the federal Home Owners' Loan Corporation . An explosion of technological advancement accompanied by the exploitation of cheap immigrant labor led to rapid economic expansion during the late 19th and early 20th centuries , allowing the United States to outpace the economies of England, France, and Germany combined. This fostered the amassing of power by

11970-520: The political drama The Quiet American which was well received by critics. The following year, he starred in the live-action/animated film Looney Tunes: Back in Action as its human lead, D.J. Drake (he also voiced the Tasmanian Devil ). In 2004, he appeared as part of an ensemble cast in the Academy Award -winning film Crash where he played the husband to Sandra Bullock's character as

12096-574: The primary colonial grievances was a denial of their rights as Englishmen , particularly the right to representation in the British government that taxed them . To demonstrate their dissatisfaction and resolve, the First Continental Congress met in 1774 and passed the Continental Association , a colonial boycott of British goods that proved effective. The British attempt to then disarm the colonists resulted in

12222-745: The production of Elling , but the play closed after one week, due to lackluster reviews. After appearing in the critically panned Furry Vengeance in 2010, Fraser moved from being represented by William Morris Endeavor to the Creative Artists Agency . In 2010, he starred in Whole Lotta Sole directed by Terry George and in 2011, he was set to play William Tell in The Legend of William Tell: 3D , directed by Eric Brevig , with whom Fraser had also worked in Journey to

12348-488: The provision of online tools aimed at assisting companies to achieve target diversity goals. BIOs members include companies that make pharmaceutical drugs , biofuels , industrial enzymes , and genetically modified crops , as well as healthcare facilities that participate in clinical trials and biopharmaceutical research. As of 2016, it represents 1,100 biotech companies in all 50 U.S. states, which employ 1.61 million Americans and support an additional 3.4 million jobs. BIO

12474-404: The qualifying therapeutic discovery project program that first became law in 2010. Examples of its public lobbying efforts, include support for development of biofuels such as those produced from algae , genetically modified crops , strong intellectual property rights, and for a more efficient and predictable regulatory process for new food and drug products. In June 2013 BIO partnered with

12600-472: The recurring cast of the television drama series The Affair during season 3 where he portrayed the misery-minded prison guard Gunther. He portrayed Getty family fixer James Fletcher Chace in the FX anthology series Trust , which premiered on March 25, 2018. Fraser portrayed Clifford "Cliff" Steele / Robotman in the Titans TV series, with Jake Michaels physically portraying Robotman. He reprised

12726-570: The rights of African Americans . National infrastructure, including transcontinental telegraph and railroads , spurred growth in the American frontier . From 1865 through 1917 an unprecedented stream of immigrants arrived in the United States, including 24.4 million from Europe. Most came through the port of New York City , and New York City and other large cities on the East Coast became home to large Jewish , Irish , and Italian populations, while many Germans and Central Europeans moved to

12852-614: The rocky Great Basin and Chihuahua , Sonoran , and Mojave deserts. In the northwest corner of Arizona , carved by the Colorado River over millions of years, is the Grand Canyon , a steep-sided canyon and popular tourist destination known for its overwhelming visual size and intricate, colorful landscape. The Sierra Nevada and Cascade mountain ranges run close to the Pacific coast . The lowest and highest points in

12978-460: The role in the spin-off series Doom Patrol , where he voices the character and appears as Steele in flashbacks; Riley Shanahan – replacing Jake Michaels in Titans – physically portrays Robotman. His comeback after a period of relative inactivity was dubbed "The Brennaissance" by fans. In an interview on The Graham Norton Show , Fraser acknowledged the portmanteau. In September 2020, Fraser

13104-704: The second sequel to The Mummy released in August 2008 and titled The Mummy: Tomb of the Dragon Emperor . Filming started in Montreal on July 27, 2007, and the film also starred Jet Li as Emperor Han. That same year, he starred in the 3D film adaptation of Jules Verne 's Journey to the Center of the Earth and the fantasy film Inkheart (chosen personally for the lead role by the novel 's author Cornelia Funke ). In 2010, Fraser returned to Broadway in

13230-573: The six service branches, which are made up of the U.S. Army , Marine Corps , Navy , Air Force , and Space Force . The Coast Guard is administered by the Department of Homeland Security in peacetime and can be transferred to the Department of the Navy in wartime. The United States spent $ 916 billion on its military in 2023, which is by far the largest amount of any country , making up 37% of global military spending and accounting for 3.4% of

13356-545: The sole authority of a state government. SDFs are authorized by state and federal law but are under the command of the state's governor . They are distinct from the state's National Guard units in that they cannot become federalized entities. A state's National Guard personnel, however, may be federalized under the National Defense Act Amendments of 1933 , which created the Guard and provides for

13482-543: The states are also represented by local elected governments , which are administrative divisions of the states. States are subdivided into counties or county equivalents , and further divided into municipalities . The District of Columbia is a federal district containing the U.S. capital, Washington, D.C. . The federal district is an administrative division of the federal government. Federally recognized tribes govern 326 Indian reservations . The United States has an established structure of foreign relations, and it has

13608-510: The structure and responsibilities of the national federal government and its relationship with the individual states. The U.S. Constitution is the world's oldest national constitution still in effect (from March 4, 1789). Composed of three branches, all headquartered in Washington, D.C., the federal government is the national government of the United States. It is regulated by a strong system of checks and balances . The three-branch system

13734-582: The world's fourth-longest river system , runs predominantly north–south through the heart of the country. The flat and fertile prairie of the Great Plains stretches to the west, interrupted by a highland region in the southeast. The Rocky Mountains , west of the Great Plains, extend north to south across the country, peaking at over 14,000 feet (4,300 m) in Colorado . Farther west are

13860-583: The world's second-largest diplomatic corps as of 2024 . It is a permanent member of the United Nations Security Council , and home to the United Nations headquarters . The United States is a member of the G7 , G20 , and OECD intergovernmental organizations. Almost all countries have embassies and many have consulates (official representatives) in the country. Likewise, nearly all countries host formal diplomatic missions with

13986-461: The world's third-largest land area , largest exclusive economic zone , and third-largest population , exceeding 334 million. Its three largest metropolitan areas are New York , Los Angeles , and Chicago , and its three most populous states are California , Texas , and Florida . Paleo-Indians migrated across the Bering land bridge more than 12,000 years ago, and formed various civilizations and societies . British colonization led to

14112-444: The world's oldest surviving federation, and its presidential system of national government has been adopted, in whole or in part, by many newly independent states worldwide following their decolonization . It is a liberal representative democracy "in which majority rule is tempered by minority rights protected by law ". The Constitution of the United States serves as the country's supreme legal document , also establishing

14238-553: The world's tornadoes occur in the country , mainly in Tornado Alley . Overall, the United States receives more high-impact extreme weather incidents than any other country. Extreme weather became more frequent in the U.S. in the 21st century, with three times the number of reported heat waves as in the 1960s. In the American Southwest , droughts became more persistent and more severe. The regions considered as

14364-506: The world, with almost 2 million people incarcerated . An analysis of the World Health Organization Mortality Database from 2010 showed U.S. homicide rates "were 7 times higher than in other high-income countries, driven by a gun homicide rate that was 25 times higher". Brendan Fraser Brendan James Fraser ( / ˈ f r eɪ z ər / FRAY -zər ; born December 3, 1968)

14490-575: Was annexed in 1845, and the 1846 Oregon Treaty led to U.S. control of the present-day American Northwest . Victory in the Mexican–American War resulted in the 1848 Mexican Cession of California, Nevada, Utah, and much of present-day Colorado and the American Southwest . The California gold rush of 1848–1849 spurred a huge migration of white settlers to the Pacific coast, leading to even more confrontations with Native populations. One of

14616-512: Was [this incident] one of them? I think it was." In contrast, Fraser also clarified in his 2019 appearance on the radio show Sway in the Morning , "I don't think the HFPA really wield that much power." In 2022, Fraser told GQ that if he received a nomination by the HFPA at that year's Golden Globes for his latest film The Whale , he would "not participate" because of the "history" he has with

14742-792: Was a guest narrator at Disney's Candlelight Processional at Walt Disney World . Shortly after arriving in Los Angeles , Fraser met actress Afton Smith while attending a barbecue at Winona Ryder 's house on July 4, 1993. Smith also appeared as a minor cast member in Fraser's George of the Jungle film. They married on September 27, 1998, and had three sons together before separating in 2007. His three sons are named Griffin Arthur Fraser, born 2002, Holden Fletcher Fraser, born 2004, and Leland Francis Fraser, born 2006. Holden and Leland are both fashion models signed with Marilyn Agency . In

14868-759: Was adopted on July 4, 1776. The political values of the American Revolution included liberty , inalienable individual rights ; and the sovereignty of the people ; supporting republicanism and rejecting monarchy , aristocracy , and all hereditary political power; civic virtue ; and vilification of political corruption . The Founding Fathers of the United States , who included Washington, Jefferson, John Adams , Benjamin Franklin , Alexander Hamilton , John Jay , James Madison , Thomas Paine , and many others, were inspired by Greco-Roman , Renaissance , and Enlightenment philosophies and ideas. The Articles of Confederation were ratified in 1781 and established

14994-540: Was announced as BIO's next CEO. Crowley has a background in rare diseases and is credited with working on a drug to save his children's and all individuals with Pompe disease 's hearts. His work was the subject of the movie Extraordinary Measures which starred Brendan Fraser and Harrison Ford . The Biotechnology Heritage Award , presented annually at the Biotechnology Innovation Organization (BIO) Annual International Convention by

15120-469: Was cast as gangster Doug Jones in Steven Soderbergh 's period crime film No Sudden Move , which was released in 2021. In January 2021, Fraser was announced as the lead in Darren Aronofsky 's film The Whale . Aronofsky stated he had looked for the lead role in the movie for a decade, and decided to cast Fraser after seeing him in the trailer of the low-budget Brazilian film Journey to

15246-645: Was cast to portray the villain Firefly in the superhero film Batgirl , set in the DC Extended Universe ; the release of the film was canceled in August 2022 after a change in Warner Bros. studio priorities. Fraser lent his voice to the audiodrama The Downloaded , written by Robert J. Sawyer , which was released in Autumn of 2023 as an Audible -exclusive audiobook. In December 2023, Fraser

15372-583: Was elected the country's first president under the Constitution, and the Bill of Rights was adopted in 1791 to allay skeptics' concerns about the power of the more centralized government. His resignation as commander-in-chief after the Revolutionary War and his later refusal to run for a third term as the country's first president established a precedent for the supremacy of civil authority in

15498-524: Was founded in 1993 in Washington, D.C. , and Carl B. Feldbaum was the president from BIO's founding until he retired in 2004. He was succeeded by James C. Greenwood who held the offices of president and CEO from 2005 to 2020. The association has a 120-member board, consisting of a diverse mix of company executives based upon size, geography, and pharmaceutical focus. The board's executive committee consists of 21 members, purposefully designed to ensure

15624-536: Was highly praised and the film received a six-minute standing ovation at the festival and subsequently won him an Oscar for Best Actor . He became the first Canadian to win the best actor award. In August of the same year, Fraser was announced as part of the cast of Martin Scorsese 's film Killers of the Flower Moon , as well as Max Barbakow's upcoming comedy film Brothers . In October 2021, Fraser

15750-787: Was part of the cast of the Pulitzer Prize winning play Cat on a Hot Tin Roof by Tennessee Williams at the Lyric Theatre, London . Fraser starred as "Brick" in the West End production of Tennessee Williams 's Cat on a Hot Tin Roof in September 2001, directed by Anthony Page . Castmates included Ned Beatty , Frances O'Connor and Gemma Jones . The show closed on January 12, 2002, with Fraser garnering many excellent reviews. In 2002, he starred alongside Michael Caine in

15876-627: Was the only Canadian to win a gold medal in the 1952 Summer Olympics , at the Olympic Trap . Fraser and his three older brothers have Irish, Scottish, German, Czech, and French-Canadian ancestry. He holds dual Canadian and American citizenship. Fraser's family moved often during his childhood, living in Eureka, California ; Seattle, Washington ; Ottawa, Ontario ; the Netherlands ; and Switzerland . His earlier years were spent attending

#190809