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55-403: Eye color is a polygenic phenotypic trait determined by two factors: the pigmentation of the eye 's iris and the frequency-dependence of the scattering of light by the turbid medium in the stroma of the iris . In humans, the pigmentation of the iris varies from light brown to black, depending on the concentration of melanin in the iris pigment epithelium (located on the back of

110-418: A locus , that accounts for a significant amount of the variation observed in the measured trait. This locus will usually contain a large number of genes that are responsible. A new form of QTL has been described as expression QTL (eQTL). eQTLs regulate the amount of expressed mRNA, which in turn regulates the amount of protein within the organism. Another interest of statistical geneticists using QTL mapping

165-412: A brown to a green. Although hazel mostly consists of brown and green, the dominant color in the eye can either be brown/gold or green. This is why hazel eyes can be mistaken as amber, and why amber is often counted as hazel in studies, and vice versa. The combination can sometimes produce a multicolored iris, i.e. an eye that is light brown/amber near the pupil and charcoal or dark green on the outer part of

220-423: A darkened, occasionally black region encircling the iris resulting from a manifestation of the optical properties of the corneal limbus . Limbal rings are not present in all individuals, and their thickness and prominence may correlate with health or youthfulness, and contributes to facial attractiveness . Although people with lighter eye color are generally more sensitive to light because they have less pigment in

275-521: A golf ball or throwing baseballs. In another study, people with darker eyes performed better at hitting racquetballs. There are also other studies that challenge these findings, and more study is needed to verify these results. Polygene Traits with polygenic determinism correspond to the classical quantitative characters , as opposed to the qualitative characters with monogenic or oligogenic determinism. In essence instead of two options, such as freckles or no freckles, there are many variations, like

330-465: A highly sexually dimorphic eye color. Studies from various populations in Europe have shown that men are substantially more likely to have blue eyes than women. The inheritance pattern followed by blue eyes was previously assumed to be a Mendelian recessive trait, though this has been shown to be incorrect. Eye color inheritance is now recognized as a polygenic trait , meaning that it is controlled by

385-413: A lightening of their eye color by adulthood. Children with green eyes often experienced a darkening of their eye color. It was also found that 11% of the children's mothers experienced an eye color change during the same period, with most developing lighter eyes, relative to their original color at the time of their child's birth. Almost all mammals have brown or darkly-pigmented irises. In humans, brown

440-495: A mutation of the gene coding for the enzyme ATPase 7B , which prevents copper within the liver from entering the Golgi apparatus in cells. Instead, the copper accumulates in the liver and in other tissues, including the iris of the eye. This results in the formation of Kayser–Fleischer rings , which are dark rings that encircle the periphery of the iris. Eye color outside of the iris may also be symptomatic of disease. Yellowing of

495-643: A part of one iris is a different color from the remainder (partial heterochromia or sectoral heterochromia). It is a result of the relative excess or lack of pigment within an iris or part of an iris, which may be inherited or acquired by disease or injury . This uncommon condition usually results due to uneven melanin content. A number of causes are responsible, including genetic, such as chimerism , Horner's syndrome and Waardenburg syndrome . A chimera can have two different colored eyes just like any two siblings can—because each cell has different eye color genes. A mosaic can have two different colored eyes if

550-405: A series of 221 photographs of Spanish subjects, 16.3% of the subjects were determined to have blue-gray eyes. Like blue eyes, gray eyes have a dark epithelium at the back of the iris and a relatively clear stroma at the front. One possible explanation for the difference in appearance between gray and blue eyes is that gray eyes have larger deposits of collagen in the stroma, so that the light that

605-643: A single gene or closely linked block of functionally related genes. In modern sense, the inheritance mode of polygenic patterns is called polygenic inheritance , whose main properties may be summarized as follows: Polygenic inheritance occurs when one characteristic is controlled by two or more genes . Often the genes are large in quantity but small in effect. Examples of human polygenic inheritance are height, skin color, eye color and weight. Polygenes exist in other organisms, as well. Drosophila , for instance, display polygeny with traits such as wing morphology, bristle count and many others. The frequency of

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660-408: A solid gold hue. Even though amber is similar to gold, some people have russet- or copper-colored amber eyes that are mistaken for hazel, though hazel tends to be duller and contains green with red/gold flecks, as mentioned above. Amber eyes may also contain amounts of very light gold-ish gray. The eyes of some pigeons contain yellow fluorescing pigments known as pteridines . The bright yellow eyes of

715-429: A strong yellowish/golden or russet/coppery tint, which may be due to a yellow pigment called lipochrome (also found in green eyes). Amber eyes should not be confused with hazel eyes. Although hazel eyes may contain specks of amber or gold, they usually tend to have many other colors, including green, brown, and orange. Also, hazel eyes may appear to shift in color and consist of flecks and ripples, while amber eyes are of

770-604: A study published in Human Genetics that a mutation in the 86th intron of the HERC2 gene, which is hypothesized to interact with the OCA2 gene promoter , reduced expression of OCA2 with subsequent reduction in melanin production. It has been proposed that blue eyes may have been adaptive to shorter day lengths at higher latitudes, as blue eyes increase intraocular light scattering, which suppresses melatonin release from

825-571: A total of ten genes, allowing the explanation of about 50% of eye color variation. Blue eyes with a brown spot, green eyes, and gray eyes are caused by an entirely different part of the genome. A 1997 study of White Americans found that eye color may be subject to change in infancy, and from adolescence to adulthood. 17% of children experienced a change of eye color by adulthood. Of those children, 50% of developed lighter eyes as they got older. The other 50% developed darker eyes. Generally, children with hazel and light brown eyes tended to experience

880-429: A variant form, causes the pink eye color and hypopigmentation common in human albinism . (The name of the gene is derived from the disorder it causes, oculocutaneous albinism type II.) Different SNPs within OCA2 are strongly associated with blue and green eyes as well as variations in freckling , mole counts, hair and skin tone . The polymorphisms may be in an OCA2 regulatory sequence , where they may influence

935-399: Is X-inactivation , which can result in a number of heterochromatic traits, such as calico cats . Trauma and certain medications, such as some prostaglandin analogues , can also cause increased pigmentation in one eye. On occasion, a difference in eye color is caused by blood staining the iris after injury. The limbal ring is also a feature of the iris contributing to eye color, appearing as

990-432: Is also associated with an increased risk of ARMD progression. A gray iris may indicate the presence of a uveitis , and an increased risk of uveal melanoma has been found in those with blue, green or gray eyes. However, a study in 2000 suggests that people with dark brown eyes are at increased risk of developing cataracts and therefore should protect their eyes from direct exposure to sunlight. Wilson's disease involves

1045-492: Is an example of structural color , which depends on the lighting conditions, especially for lighter-colored eyes. The brightly colored eyes of many bird species result from the presence of other pigments, such as pteridines , purines , and carotenoids . Humans and other animals have many phenotypic variations in eye color. The genetics and inheritance of eye color in humans is complicated. As of 2010, as many as 16 genes have been associated with eye color inheritance. Some of

1100-522: Is by far the most common eye color, with approximately 79% of people in the world having it. Brown eyes result from a relatively high concentration of melanin in the stroma of the iris, which causes light of both shorter and longer wavelengths to be absorbed. In many parts of the world, it is nearly the only iris color present. Brown eyes are common in Europe , East Asia , Southeast Asia , Central Asia , South Asia , West Asia , Oceania , West Africa and

1155-485: Is reflected from the epithelium undergoes Mie scattering (which is not strongly frequency-dependent) rather than Rayleigh scattering (in which shorter wavelengths of light are scattered more). This would be analogous to the change in the color of the sky, from the blue given by the Rayleigh scattering of sunlight by small gas molecules when the sky is clear, to the gray caused by Mie scattering of large water droplets when

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1210-474: Is the third-rarest natural eye color after green and gray, occurring in 5% of the world's population. People with amber-colored eyes are found in Europe , and in fewer numbers in the Middle East , North Africa , and South America . Hazel eyes are due to a combination of Rayleigh scattering and a moderate amount of melanin in the iris' anterior border layer. Hazel eyes often appear to shift in color from

1265-411: Is therefore a major factor in the expression of eye color genotypes. One study suggested that women's higher levels of the sex hormone estrogen may explain why women tend to have darker eyes than men. People of European descent show the greatest variety in eye color of any population worldwide. Recent advances in ancient DNA technology have revealed some of the history of eye color in Europe. Through

1320-690: Is to determine the complexity of the genetic architecture underlying a phenotypic trait. For example, they may be interested in knowing whether a phenotype is shaped by many independent loci, or by a few loci, and do those loci interact. This can provide information on how the phenotype may be evolving. SLC24A4 123041 238384 ENSG00000140090 ENSMUSG00000041771 Q8NFF2 Q8CGQ8 NM_153646 NM_153647 NM_153648 NM_001378620 NM_172152 NM_001362345 NP_705932 NP_705933 NP_705934 NP_001365549 NP_742164 NP_001349274 Sodium/potassium/calcium exchanger 4 also known as solute carrier family 24 member 4

1375-487: Is unknown, but there are a few likely candidates. A study in Rotterdam (2009) found that it was possible to predict eye color with more than 90% accuracy for brown and blue using just six SNPs. In humans, eye color is a highly sexually dimorphic trait. Several studies have shown that men are more likely to have blue eyes than women, while women are more likely to have darker eye colors (green and brown eyes) than men. Sex

1430-517: The Americas . Light or medium-pigmented brown eyes can also be commonly found in Europe , among the Americas , and parts of Central Asia , West Asia , South Asia , and East Africa . Light brown eyes bordering amber and hazel coloration are more common in Europe , but can also be observed in East Asia , Southeast Asia , North Africa and East Africa . Amber eyes are a solid color with

1485-844: The Netherlands and the United Kingdom , and have also been observed to be very common among the Low Saxon -speaking populations of northern Germany. Green eyes probably result from the interaction of multiple allelic variants of OCA2 and other genes. They may have been present in southern Siberia during the Bronze Age . Green eyes are most common in Northern , Western , and Central Europe . Around 8–10% of men and 18–21% of women in Iceland and 6% of men and 17% of women in

1540-406: The Netherlands have green eyes. Among European Americans , green eyes are most common among those of recent Celtic and Germanic ancestry, occurring in about 16% of people with those backgrounds. The green color is caused by the combination of: 1) an amber or light brown pigmentation in the stroma of the iris (which has a low or moderate concentration of melanin), and 2) a blue shade created by

1595-451: The great horned owl are thought to be due to the presence of the pteridine pigment xanthopterin within certain chromatophores (called xanthophores) located in the iris stroma. In humans, yellowish specks or patches are thought to be due to the pigment lipofuscin , also known as lipochrome. Many animals such as canines, domestic cats, owls, eagles, pigeons, and fish have amber eyes, whereas in humans this color occurs less frequently. Amber

1650-538: The pineal gland , perhaps reducing psychological depression (which is linked to the short day length of higher latitudes). Blue eyes are predominant in northern and eastern Europe, particularly around the Baltic Sea . Blue eyes are also found in Southern Europe , Central Asia , South Asia , North Africa , and West Asia . Approximately 8% to 10% of the global population have blue eyes. A 2002 study found

1705-403: The sclera (the "whites of the eyes") is associated with jaundice , and may be symptomatic of liver diseases such as cirrhosis or hepatitis . A blue coloration of the sclera may also be symptomatic of disease. Aniridia is a congenital condition characterized by an extremely underdeveloped iris, which appears absent on superficial examination. Normally, there is a thick layer of melanin on

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1760-525: The DNA difference happens to be in an eye-color gene. There are many other possible reasons for having two different-colored eyes. For example, the film actor Lee Van Cleef was born with one blue eye and one green eye, a trait that reportedly was common in his family, suggesting that it was a genetic trait. This anomaly, which film producers thought would be disturbing to film audiences, was "corrected" by having Van Cleef wear brown contact lenses. David Bowie , on

1815-453: The Rayleigh scattering of reflected light. Green eyes contain the yellowish pigment lipochrome . There is no intrinsically blue pigmentation either in the iris or in the vitreous body . Rather, blue eyes result from structural color in combination with certain concentrations of non-blue pigments. The iris pigment epithelium is brownish black due to the presence of melanin . Unlike brown eyes, blue eyes have low concentrations of melanin in

1870-661: The analysis of ancient DNA, a 2020 study published in Experimental Dermatology suggested that the common gene for blue eye color likely originated in the Near East and arrived in Europe around 42,000 years ago, after the exodus out of Africa . There is evidence that as many as 16 different genes could be responsible for eye color in humans; however, the main two genes associated with eye color variation are OCA2 and HERC2 , and both are localized in chromosome 15 . The gene OCA2 (OMIM: 203200 ), when in

1925-424: The back of the iris. Even people with the lightest blue eyes, with no melanin on the front of the iris at all, have dark brown coloration on the back of it, to prevent light from scattering around inside the eye. In those with milder forms of albinism , the color of the iris is typically blue but can vary from blue to brown. In severe forms of albinism, there is no pigment on the back of the iris, and light from inside

1980-408: The color of skin, hair, or even eyes. Polygenic locus is any individual locus which is included in the system of genes responsible for the genetic component of variation in a quantitative (polygenic) character. Allelic substitutions contribute to the variance in a specified quantitative character. Polygenic locus may be either a single or complex genetic locus in the conventional sense, i.e., either

2035-411: The distribution on a fine scale. Traditionally, mapping polygenes requires statistical tools available to help measure the effects of polygenes as well as narrow in on single genes. One of these tools is QTL-mapping . QTL-mapping utilizes a phenomenon known as linkage disequilibrium by comparing known marker genes with correlated phenotypes. Often, researchers will find a large region of DNA, called

2090-457: The expression of the gene product, which in turn affects pigmentation. A specific mutation within the HERC2 gene, a gene that regulates OCA2 expression, is partly responsible for blue eyes. Other genes implicated in eye color variation are SLC24A4 and TYR . A 2010 study of eye color variation in hue and saturation values using high-resolution digital full-eye photographs found three new loci for

2145-588: The extremely low quantities of melanin , allowing the blood vessels to show through. In addition, flash photography can sometimes cause a " red-eye effect ", in which the very bright light from a flash reflects off the retina, which is abundantly vascular, causing the pupil to appear red in the photograph. Although the deep blue eyes of some people such as Elizabeth Taylor can appear purple or violet at certain times, "true" violet-colored eyes occur only due to albinism. Eyes that appear red or violet under certain conditions due to albinism occur in less than 1 percent of

2200-447: The eye can pass through the iris to the front. In these cases, the only color seen is the red from the hemoglobin of the blood in the capillaries of the iris. Such albinos have pink eyes, as do albino rabbits, mice, or any other animal with a total lack of melanin. Transillumination defects can almost always be observed during an eye examination due to lack of iridial pigmentation. The ocular albino also lacks normal amounts of melanin in

2255-527: The eye-color genes include OCA2 and HERC2 . The earlier belief that blue eye color is a recessive trait has been shown to be incorrect, and the genetics of eye color are so complex that almost any parent-child combination of eye colors can occur. Eye color is an inherited trait determined by multiple genes . These genes are sought by studying small changes in the genes themselves and in neighboring genes, called single-nucleotide polymorphisms or SNPs. The total number of genes that contribute to eye color

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2310-433: The fact that human height follows a smooth bell curve implies that there can be no single gene (or even small cluster of genes) that control height under ordinary circumstances. However, in this model all genes must code for alleles with additive effects. This assumption is often unrealistic as many genes display epistasis effects which can have unpredictable effects on the distribution of outcomes, especially when looking at

2365-575: The interactions of several genes. In 2008, a team of researchers from the University of Copenhagen located a single mutation that causes the phenomenon of blue eyes. The research was published in the Journal of Human Genetics . The same DNA sequence of the OCA2 gene among blue-eyed people suggests they may have a single common ancestor. The researchers hypothesized that the OCA2 mutation responsible for blue eyes arose in an individual who lived in

2420-475: The iris (or vice versa) when observed in sunlight. Definitions of the eye color "hazel" vary: it is sometimes considered to be synonymous with light brown or gold, as in the color of a hazelnut shell. Around 18% of the US population and 5% of the world population have hazel eyes. 55.2% of Spanish subjects in a series of 221 photographs were judged to have hazel eyes. Hazel eyes are found in Europe , most commonly in

2475-431: The iris to protect them from sunlight, there is little to no evidence that eye color has a direct impact on vision qualities such as visual acuity . However, there is a study that found that dark-eyed people perform better at "reactive-type tasks", which suggests they may have better reaction times. People with light-colored eyes, however, performed better at so-called "self-paced tasks", which include activities like hitting

2530-459: The iris), the melanin content within the iris stroma (located at the front of the iris), and the cellular density of the stroma. The appearance of blue, green, and hazel eyes results from the Tyndall scattering of light in the stroma, a phenomenon similar to Rayleigh scattering which accounts for the blue sky. Neither blue nor green pigments are present in the human iris or vitreous humour . This

2585-443: The iris. Gray is the second-rarest natural eye color after green, with 3% of the world's population having it. As a result of heterochromia iridum , it is also possible to have two different eye colors. This occurs in humans and certain breeds of domesticated animals and affects less than 1 percent of the world's population. The eyes of people with severe forms of albinism may appear red under certain lighting conditions owing to

2640-693: The northwestern part of the Black Sea region in Europe sometime between 6,000 and 10,000 years ago, during the Neolithic period. However, more recent ancient DNA research has identified human remains much older than the Neolithic period which possess the OCA2 mutation for blue eyes. It is now believed that the OCA2 allele responsible for blue eyes dates back to the migration of modern humans out of Africa roughly 50,000 years ago, and entered Europe from western Asia. Eiberg and colleagues suggested in

2695-428: The other hand, had the appearance of different eye colors due to an injury that caused one pupil to be permanently dilated. Another hypothesis about heterochromia is that it can result from a viral infection in utero affecting the development of one eye, possibly through some sort of genetic mutation. Occasionally, heterochromia can be a sign of a serious medical condition. A common cause in females with heterochromia

2750-631: The phenotypes of these traits generally follows a normal continuous variation distribution pattern. This results from the many possible allelic combinations. When the values are plotted, a bell-shaped "normal" curve is obtained. The mode of the distribution represents the optimal, or fittest, phenotype. The more genes are involved, the smoother the estimated curve, which follows from the Central Limit Theorem . This implies that traits such as height that are both highly heritable and normally distributed are necessarily polygenic. In other words,

2805-495: The prevalence of blue eye color among the white population in the United States to be 33.8% for those born from 1936 through 1951, compared with 57.4% for those born from 1899 through 1905. As of 2006, one out of every six Americans, or 16.6% of the total US population, has blue eyes, including 22.3% of whites. The incidence of blue eyes continues to decline among American children. Of Slovenes , 56% have blue/green eyes. In

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2860-426: The retina as well, which allows more light than normal to reflect off the retina and out of the eye. Because of this, the pupillary reflex is much more pronounced in albino individuals, and this can emphasize the red eye effect in photographs. Heterochromia ( heterochromia iridum or heterochromia iridis ) is an eye condition in which one iris is a different color from the other (complete heterochromia), or where

2915-796: The sky is cloudy. Alternatively, it has been suggested that gray and blue eyes might differ in the concentration of melanin at the front of the stroma. Gray eyes can also be found among the Algerian Shawia people of the Aurès Mountains in Northwest Africa, in the Middle East / West Asia , Central Asia , and South Asia . In the Iliad , the Greek goddess Athene is said to have gray eyes (γλαυκῶπις). Under magnification, gray eyes exhibit small amounts of yellow and brown color in

2970-453: The stroma of the iris, which lies in front of the dark epithelium. Longer wavelengths of light tend to be absorbed by the dark underlying epithelium, while shorter wavelengths are reflected and undergo Rayleigh scattering in the turbid medium of the stroma. This is the same scattering that accounts for the blue appearance of the sky. The result is a " Tyndall blue" structural color that varies with external lighting conditions. Blue eyes are

3025-478: The world's population. The most important role of melanin in the iris is to protect the eyes from the sun's harmful rays. People with lighter eye colors, such as blue or green, have lessened protection from the sun, and so need greater protection from the sun's rays than those with darker eye colors. Those with lighter iris color have been found to have a higher prevalence of age-related macular degeneration (ARMD) than those with darker iris color; lighter eye color

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