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102-497: Most parts of this region are heavily eroded, which required farmers to protect their enset fields with stone and soil bunds. During the 1930s, about 20% of the land in Gurage was covered with natural forests, which has since been almost completely cut down; the removal was especially fast during the years 1991 and 1992. As of 1996 one of the largest natural forests is Ziarem forest (also known as Forehina), about 800 hectares in size. On

204-575: A blood meal from a previously Plasmodium infected person or animal. Parasites are then typically introduced by the bite of an infected Anopheles mosquito. Some of these inoculated parasites, called " sporozoites ", probably remain in the skin, but others travel in the bloodstream to the liver , where they invade hepatocytes . They grow and divide in the liver for 2–10 days, with each infected hepatocyte eventually harboring up to 40,000 parasites. The infected hepatocytes break down, releasing these invasive Plasmodium cells, called " merozoites ", into

306-462: A child under five died of malaria in 2021, and "many of these deaths are preventable and treatable". Malaria is commonly associated with poverty and has a significant negative effect on economic development. In Africa, it is estimated to result in losses of US$ 12 billion a year due to increased healthcare costs, lost ability to work, and adverse effects on tourism. The term malaria originates from Medieval Italian : mala aria 'bad air',

408-414: A consistent supply of microscopy slides and stains. In places where microscopy is unavailable, malaria is diagnosed with RDTs, rapid antigen tests that detect parasite proteins in a fingerstick blood sample. A variety of RDTs are commercially available, targeting the parasite proteins histidine rich protein 2 (HRP2, detects P. falciparum only), lactate dehydrogenase , or aldolase . The HRP2 test

510-562: A description and quite accurate drawings of a plant common in the marshes around Gondar in Ethiopia, confidently pronounced it to be "no species of Musa" and wrote that its local name was "ensete". In 1853 the British Consul at Mussowah sent some seeds to Kew Gardens , mentioning that their native name was ansett . Kew, quite understandably, did not make the connection, especially as they had never before seen such seeds. However, when

612-417: A fire. Kocho is in places regarded as a delicacy, suitable for serving at feasts and ceremonies such as weddings, when wheat flour is added. The fresh corm is cooked like potatoes before eating. Dry kocho and bulla are energy-rich and produce from 14 to 20 kJ/g (3.3 to 4.8 kcal/g). It is a major crop, although often supplemented with cereal crops. However its value as a famine food has fallen for

714-472: A greater likelihood of complications and death. Malaria infection affects the immune responses following vaccination for various diseases. For example, malaria suppresses immune responses to polysaccharide vaccines. A potential solution is to give curative treatment before vaccination in areas where malaria is present. Due to the non-specific nature of malaria symptoms, diagnosis is typically suspected based on symptoms and travel history, then confirmed with

816-563: A harvest estimated to be almost 10 tonnes per hectare (4.0 long ton/acre; 4.5 short ton/acre). Enset is often intercropped with sorghum , although the practice amongst the Gedeo people is to intercrop it with coffee . The young and tender tissues in the centre or heart of the plant (the growing point ) are cooked and eaten, being tasty and nutritious and very like the core of palms and cycads. In Ethiopia, more than 150,000 hectares (370,000 acres; 580 sq mi) are cultivated for

918-456: A laboratory test showing hemoglobin levels below 8 grams per deciliter of blood. In areas of the world with little to no malaria, the WHO recommends only testing people with possible exposure to malaria (typically travel to a malaria-endemic area) and unexplained fever. In sub-Saharan Africa, testing is low, with only about one in four (28%) of children with a fever receiving medical advice or

1020-488: A laboratory test to detect the presence of the parasite in the blood (parasitological test). In areas where malaria is common, the World Health Organization (WHO) recommends clinicians suspect malaria in any person who reports having fevers, or who has a current temperature above 37.5 °C without any other obvious cause. Malaria should be suspected in children with signs of anemia : pale palms or

1122-534: A large amount of sweat on the surface of the skin. Due to the high levels of lactic acid released from the human body, it has been hypothesized to represent a specific human host-recognition cue for anthropophilic (attracted to humans) mosquitoes. Pungent foot odor Most studies use human odors as stimuli to attract host seeking mosquitoes and have reported a strong and significant attractive effect. The studies have found human odor samples very effective in attracting mosquitoes. Foot odors have been demonstrated to have

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1224-636: A less pronounced and almost continuous fever. Symptoms typically begin 10–15 days after the initial mosquito bite, but can occur as late as several months after infection with some P. vivax strains. Travellers taking preventative malaria medications may develop symptoms once they stop taking the drugs. Severe malaria is usually caused by P. falciparum (often referred to as falciparum malaria). Symptoms of falciparum malaria arise 9–30 days after infection. Individuals with cerebral malaria frequently exhibit neurological symptoms, including abnormal posturing , nystagmus , conjugate gaze palsy (failure of

1326-435: A non-invasive way to detect malarial infections. In addition, these volatile compounds were heavily detected by mosquito antennae as an attractant, making the children more vulnerable to the bite of the mosquitos. Fatty acids Fatty acids have been identified as an attractive compound for mosquitoes, they are typically found in volatile emissions from the skin. These fatty acids that produce body odor profiles originate from

1428-648: A number of reasons, as detailed in the April 2003 issue of the UN-OCHA Ethiopia unit's Focus on Ethiopia : Apart from an enset plant disease epidemic in 1984–85 which wiped out large parts of the plantations and created the green famine, in the past 10 years major factors were recurrent drought and food shortage together with acute land shortage that forced farmers more and more into consumption of immature plants. Hence farmers were overexploiting their Enset reserves thereby causing gradual losses and disappearance of

1530-564: A part of miasma theory ; the disease was formerly called ague or marsh fever due to its association with swamps and marshland. The term appeared in English at least as early as 1768. Malaria was once common in most of Europe and North America, where it is no longer endemic, though imported cases do occur. The scientific study of malaria is called malariology. Adults with malaria tend to experience chills and fever—classically in periodic intense bouts lasting around six hours, followed by

1632-530: A period of sweating and fever relief—as well as headache, fatigue, abdominal discomfort, and muscle pain . Children tend to have more general symptoms: fever, cough, vomiting, and diarrhea. Initial manifestations of the disease—common to all malaria species—are similar to flu-like symptoms , and can resemble other conditions such as sepsis , gastroenteritis , and viral diseases . The presentation may include headache , fever , shivering , joint pain , vomiting , hemolytic anemia , jaundice , hemoglobin in

1734-575: A postdoctoral scholar at the University of California, Berkeley studying the structural basis of membrane manipulation and cell-cell fusion by bacterial pathogens, discusses studies that determine how odor profiles can be used to diagnose the disease. Within the study, samples of volatile compounds from around 400 children within schools in Western Kenya were collected - to identify asymptomatic infections. These biomarkers have been established as

1836-635: A rapid diagnostic test in 2021. There was a 10-percentage point gap in testing between the richest and the poorest children (33% vs 23%). Additionally, a greater proportion of children in Eastern and Southern Africa (36%) were tested than in West and Central Africa (21%). According to UNICEF, 61% of children with a fever were taken for advice or treatment from a health facility or provider in 2021. Disparities are also observed by wealth, with an 18 percentage point difference in care-seeking behaviour between children in

1938-525: A road density of 95.4 kilometers per 1000 square kilometers, the average rural household has 0.5 hectare of land (compared to the national average of 1.01 hectare of land and an average of 0.89 for the SNNPR) the equivalent of 0.2 heads of livestock. 18.9% of the population is in non-farm related jobs, compared to the national average of 25% and a Regional average of 32%. 79% of all eligible children are enrolled in primary school, and 12% in secondary schools. 18% of

2040-411: A short time) and it can be harvested at any development stage. Nevertheless, in recent years, the population growth has put pressure on enset cultivation systems. This is mainly because of a decrease of fertilization through manure and an increase in demand, especially during droughts. At such times, enset becomes the only resource available. Gender roles in enset cultivation are of high importance, as

2142-466: A short time, and a "thin film" of blood, allowing them to clearly see individual parasites and identify the infecting Plasmodium species. Under typical field laboratory conditions, a microscopist can detect parasites when there are at least 100 parasites per microliter of blood, which is around the lower range of symptomatic infection. Microscopic diagnosis is relatively resource intensive, requiring trained personnel, specific equipment, electricity, and

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2244-595: A small proportion of public expenditure on health. In contrast, a similar programme in Tanzania would cost an estimated one-fifth of the public health budget. In 2021, the World Health Organization confirmed that China has eliminated malaria. In 2023, the World Health Organization confirmed that Azerbaijan , Tajikistan , and Belize have eliminated malaria. In areas where malaria is common, children under five years old often have anaemia , which

2346-419: A strong division of work exists: generally men are responsible for the propagation, cultivation, and transplanting of enset, while women are in charge of manuring, hand-weeding, thinning and landrace selection. Additionally, women process enset plants, which is a tedious work (transformation of the plant into useful material, principally food and fibres) for which they generally come together. Men are banned from

2448-573: A viable alternative, have become food insecure and highly vulnerable to climatic and economic disruptions of their agricultural system. The plant is quick-growing and often cultivated as an ornamental plant. In frost-prone areas it requires winter protection under glass. It has gained the Royal Horticultural Society 's Award of Garden Merit , as has the cultivar 'Maurelii' (Ethiopian black banana) A good quality fibre, suitable for ropes, twine, baskets, and general weaving,

2550-518: A way past the net. Insecticide-treated nets (ITNs) are estimated to be twice as effective as untreated nets and offer greater than 70% protection compared with no net. Between 2000 and 2008, the use of ITNs saved the lives of an estimated 250,000 infants in Sub-Saharan Africa. According to UNICEF, only 36% of households had sufficient ITNs for all household members in 2019. In 2000, 1.7 million (1.8%) African children living in areas of

2652-479: Is a feature of blackwater fever , where haemoglobin from lysed red blood cells leaks into the urine. Infection with P. falciparum may result in cerebral malaria, a form of severe malaria that involves encephalopathy . It is associated with retinal whitening, which may be a useful clinical sign in distinguishing malaria from other causes of fever. An enlarged spleen , enlarged liver or both of these , severe headache, low blood sugar , and haemoglobin in

2754-518: Is associated with potentially life-threatening conditions about as often as with a diagnosis of P. falciparum infection. P. vivax proportionally is more common outside Africa. Some cases have been documented of human infections with several species of Plasmodium from higher apes , but except for P. knowlesi —a zoonotic species that causes malaria in macaques —these are mostly of limited public health importance. The Anopheles mosquitos initially get infected by Plasmodium by taking

2856-618: Is caused by Mycospharella spp . and is commonly called black Sigatoka leaf streaks. The symptoms are basically dark/brown lesions surrounded by yellow on the leaves. This disease happens to be favoured by high rainfall and lower temperature. Enset cultivation in Ethiopia is reported to be 10,000 years old, though there is little empirical evidence to support this. It has major economic, social, cultural and environmental functions related to trade, medicine, cultural identity, rituals or settlement patterns. The Enset-planting complex

2958-446: Is caused by six Plasmodium species: P. falciparum , P. malariae , P. ovale curtisi , P. ovale wallikeri , P. vivax and P. knowlesi . Among those infected, P. falciparum is the most common species identified (~75%) followed by P. vivax (~20%). Although P. falciparum traditionally accounts for the majority of deaths, recent evidence suggests that P. vivax malaria

3060-465: Is deemed severe when any of the following criteria are present, otherwise it is considered uncomplicated. Cerebral malaria is defined as a severe P. falciparum -malaria presenting with neurological symptoms, including coma (with a Glasgow coma scale less than 11, or a Blantyre coma scale less than 3), or with a coma that lasts longer than 30 minutes after a seizure. Methods used to prevent malaria include medications, mosquito elimination and

3162-486: Is estimated that 40 to 60 enset plants occupying 250–375 square metres (2,700–4,000 sq ft) can provide enough food for a family of 5 to 6 people." Enset ( E. ventricosum ) is Ethiopia's most important root crop , a traditional staple in the densely populated south and southwestern parts of Ethiopia. Its importance to the diet and economy of the Gurage and Sidama peoples was first recorded by Jerónimo Lobo in

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3264-534: Is important for agro- and biodiversity. The farmers’ main interest for maintaining biodiversity is the different beneficial characteristics of each variety. This means that Ethiopian farmers spread important characteristics over many enset varieties instead of combining a number of desired characteristics in one single genotype This is a significant difference between Ethiopian subsistence farmers’ and plant breeders’ approaches. More than 11 ethnic groups with different cultures, traditions and agricultural systems inhabit

3366-531: Is insufficient evidence that mosquito repellents can prevent malaria infection. Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) are effective, have been commonly used to prevent malaria, and their use has contributed significantly to the decrease in malaria in the 21st century. ITNs and IRS may not be sufficient to eliminate the disease, as these interventions depend on how many people use nets, how many gaps in insecticide there are (low coverage areas), if people are not protected when outside of

3468-451: Is not available. In areas where the disease is common, malaria should be confirmed if possible before treatment is started due to concerns of increasing drug resistance . Resistance among the parasites has developed to several antimalarial medications; for example, chloroquine -resistant P. falciparum has spread to most malarial areas, and resistance to artemisinin has become a problem in some parts of Southeast Asia . The disease

3570-425: Is obtained from the leaves. Dried leaf-sheaths are used as packing material, serving the same function as Western foam plastic and polystyrene. The entire plant but the roots is used to feed livestock. Fresh leaves are a common fodder for cattle during the dry season, and many farmers feed their animals with residues of enset harvest or processing. In 1769, the celebrated Scottish traveller James Bruce first sent

3672-750: Is often neglected or considered of lesser importance than men's by researchers and farmers and women are less likely to get access to extension services and quality services than men. Another important aspect in which gender plays a role is in the classification of enset varieties. Indeed, they differentiate "male" varieties from "female" varieties, according to the preferences of men and women who harvest them. Whereas men prefer late maturing genotypes resistant to diseases, women prefer varieties that are good for cooking and can be harvested for consumption at an earlier stage. In general, households tend to have slightly more “female” genotypes than "male" ones. In Ethiopia, over 300 enset varieties have been recorded which

3774-419: Is one of the four farming systems of Ethiopia together with pastoralism, shifting cultivation and the seed-farming complex. It is widely used by around 20 million people, which represent 20-25% of the population. They mainly live in the densely populated highlands of south and southwest Ethiopia. The plant is very important for food security because it is quite resistant to droughts (the growth only stops for

3876-449: Is preserved not only due to the presence of different ethnic groups but also due to different households’ wealth status. Richer farmers can generally afford to maintain a higher level of farm biodiversity because they have more resources such as land, labour and livestock. Therefore, they can cultivate more varieties with differing specific characteristics. However, also poorer households try to maintain as many clones as possible by selecting

3978-400: Is relatively invisible to immune surveillance. However, circulating infected blood cells are destroyed in the spleen . To avoid this fate, the P. falciparum parasite displays adhesive proteins on the surface of the infected blood cells, causing the blood cells to stick to the walls of small blood vessels, thereby sequestering the parasite from passage through the general circulation and

4080-449: Is sometimes due to malaria. Giving children with anaemia in these areas preventive antimalarial medication improves red blood cell levels slightly but does not affect the risk of death or need for hospitalisation. Vector control refers to methods used to decrease malaria by reducing the levels of transmission by mosquitoes. For individual protection, the most effective insect repellents are based on DEET or picaridin . However, there

4182-408: Is spread exclusively through bites of infected female Anopheles mosquitoes. The mosquito bite introduces the parasites from the mosquito's saliva into a person's blood. The parasites travel to the liver , where they mature and reproduce. Five species of Plasmodium commonly infect humans. The three species associated with more severe cases are P. falciparum (which is responsible for

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4284-425: Is typical) to several years. After a period of dormancy, they reactivate and produce merozoites. Hypnozoites are responsible for long incubation and late relapses in P. vivax infections, although their existence in P. ovale is uncertain. The parasite is relatively protected from attack by the body's immune system because for most of its human life cycle it resides within the liver and blood cells and

4386-413: Is typically attributed to treatment failure. People may develop some immunity when exposed to frequent infections. Malaria infection develops via two phases: one that involves the liver (exoerythrocytic phase), and one that involves red blood cells, or erythrocytes (erythrocytic phase). When an infected mosquito pierces a person's skin to take a blood meal, sporozoites in the mosquito's saliva enter

4488-818: Is widely used in Africa, where P. falciparum predominates. However, since HRP2 persists in the blood for up to five weeks after an infection is treated, an HRP2 test sometimes cannot distinguish whether someone currently has malaria or previously had it. Additionally, some P. falciparum parasites in the Amazon region lack the HRP2 gene, complicating detection. RDTs are fast and easily deployed to places without full diagnostic laboratories. However they give considerably less information than microscopy, and sometimes vary in quality from producer to producer and lot to lot. Serological tests to detect antibodies against Plasmodium from

4590-567: Is widespread in the tropical and subtropical regions that exist in a broad band around the equator . This includes much of sub-Saharan Africa , Asia , and Latin America . In 2022, some 249 million cases of malaria worldwide resulted in an estimated 608,000 deaths, with 80 percent being five years old or less. Around 95% of the cases and deaths occurred in sub-Saharan Africa. Rates of disease decreased from 2010 to 2014, but increased from 2015 to 2021. According to UNICEF, nearly every minute,

4692-825: The Central Statistical Agency of Ethiopia (CSA), Gurage has a total population of 1,280,483. The six largest ethnic groups reported in Gurage Zone were the Gurage people (82%), the Mareqo or Libido (4.28%), the Amhara (3.36%), the Kebena (3.34%), the Silt'e people (2.71%), and the Oromo (1.69%); all other ethnic groups made up 2.62% of the population. Gurage languages are spoken as a first language by 80.54% of

4794-467: The banana family Musaceae . The domesticated form of the plant is cultivated only in Ethiopia, where it provides the staple food for approximately 20 million people. The name Ensete ventricosum was first published in the Kew Bulletin 1947, p. 101. Its synonyms include Musa arnoldiana De Wild., Musa ventricosa Welw. and Musa ensete J. F. Gmelin . In its wild form, it is native to

4896-411: The bone marrow for 11 days, then return to the blood circulation to await uptake by the bite of another mosquito. Once inside a mosquito, the gametocytes undergo sexual reproduction, and eventually form daughter sporozoites that migrate to the mosquito's salivary glands to be injected into a new host when the mosquito bites. The liver infection causes no symptoms; all symptoms of malaria result from

4998-491: The polymerase chain reaction to detect the parasite's DNA have been developed, but they are not widely used in areas where malaria is common, due to their cost and complexity. The risk of disease can be reduced by preventing mosquito bites through the use of mosquito nets and insect repellents or with mosquito-control measures such as spraying insecticides and draining standing water . Several medications are available to prevent malaria for travellers in areas where

5100-644: The 1994 census, the six largest ethnic groups reported in Gurage Zone were the Sebat Bet Gurage (45.02%), the Silt'e (34.81%), the Soddo Gurage (9.75%), the Mareqo or Libido (2.21%), the Amhara (2.16%), and the Kebena (1.82%); all other ethnic groups made up 4.21% of the population. Sebat Bet Gurage is spoken as a first language by 39.93%, 35.04% Silt'e , 10.06% spoke Soddo Gurage , 3.93% spoke Amharic , 2.16% spoke Libido , and 1.93% spoke Kebena ;

5202-489: The Kore people. The first observation of this disease was reported by Yirgou and Bradbury in 1968. The manifestation of the bacterial wilt is taking place in the apical leaves that will wilt then dry and finally lead to the drying of the whole plant. The only way to avoid the spreading of the disease is in uprooting, burning and burying plants as well as in applying strict control of the knives and tools used to harvest and treat

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5304-405: The absence of Duffy antigens on red blood cells. The impact of sickle cell trait on malaria immunity illustrates some evolutionary trade-offs that have occurred because of endemic malaria. Sickle cell trait causes a change in the haemoglobin molecule in the blood. Normally, red blood cells have a very flexible, biconcave shape that allows them to move through narrow capillaries ; however, when

5406-418: The blood have been developed, but are not used for malaria diagnosis due to their relatively poor sensitivity and specificity. Highly sensitive nucleic acid amplification tests have been developed, but are not used clinically due to their relatively high cost, and poor specificity for active infections. Malaria is classified into either "severe" or "uncomplicated" by the World Health Organization (WHO). It

5508-430: The bloodstream and migrate to the liver where they infect hepatocytes, multiplying asexually and asymptomatically for a period of 8–30 days. After a potential dormant period in the liver, these organisms differentiate to yield thousands of merozoites, which, following rupture of their host cells, escape into the blood and infect red blood cells to begin the erythrocytic stage of the life cycle. The parasite escapes from

5610-540: The bloodstream. In the blood, the merozoites rapidly invade individual red blood cells , replicating over 24–72 hours to form 16–32 new merozoites. The infected red blood cell lyses, and the new merozoites infect new red blood cells, resulting in a cycle that continuously amplifies the number of parasites in an infected person. Over rounds of this infection cycle, a small portion of parasites do not replicate, but instead develop into early sexual stage parasites called male and female " gametocytes ". These gametocytes develop in

5712-408: The brain, they contribute to coma . In the placenta they contribute to low birthweight and preterm labor, and increase the risk of abortion and stillbirth. The destruction of red blood cells during infection often results in anemia, exacerbated by reduced production of new red blood cells during infection. Only female mosquitoes feed on blood; male mosquitoes feed on plant nectar and do not transmit

5814-434: The cause, recurrence can be classified as either recrudescence , relapse , or reinfection. Recrudescence is when symptoms return after a symptom-free period due to failure to remove blood-stage parasites by adequate treatment. Relapse is when symptoms reappear after the parasites have been eliminated from the blood but have persisted as dormant hypnozoites in liver cells. Relapse commonly occurs between 8 and 24 weeks after

5916-416: The cavities. The nematode infestation leads to the easy uprooting of the affected plants. Crop rotation can counteract high nematode infestations. The enset plant can be subject to multiple diseases that threaten its use in agriculture. The most well known of them is the infection by the bacteria Xanthomonas campestris pathovar Musacerum which creates bacterial wilt, also known as borijje and wol’a by

6018-426: The corm and pseudostem . As for the nematodes , there are two predominant species: there are the root lesion nematodes ( Pratylenchus goodeyi ) and the root-knot nematodes ( Meloidogyne sp.) and their appearance stand in connection with bacterial wilt. Pratylenchus goodeyi create lesions on the corm and roots, which can lead to cavities up to 2 cm (0.79 in) and characteristic purple colouring around

6120-508: The cultivation of enset is its vulnerability to several pests and diseases. The most common pest that threatens enset is caused by the Cataenococcus enset which is a root mealybug . The Cataenococcus enset feeds on the roots and corm of the enset plant which leads to slower growth and easier uprooting. Even though enset can be infested at all age stages, the highest risk is between the second or fourth growth year. The dispersion of

6222-521: The development of respiratory distress , which occurs in up to 25% of adults and 40% of children with severe P. falciparum malaria. Possible causes include respiratory compensation of metabolic acidosis , noncardiogenic pulmonary oedema , concomitant pneumonia , and severe anaemia . Although rare in young children with severe malaria, acute respiratory distress syndrome occurs in 5–25% of adults and up to 29% of pregnant women. Coinfection of HIV with malaria increases mortality. Kidney failure

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6324-509: The disease in the long run, but the initial costs required are out of reach of many of the world's poorest people. There is a wide difference in the costs of control (i.e. maintenance of low endemicity) and elimination programs between countries. For example, in China—whose government in 2010 announced a strategy to pursue malaria elimination in the Chinese provinces —the required investment is

6426-578: The disease is common. Occasional doses of the combination medication sulfadoxine/pyrimethamine are recommended in infants and after the first trimester of pregnancy in areas with high rates of malaria. As of 2023, two malaria vaccines have been endorsed by the World Health Organization . The recommended treatment for malaria is a combination of antimalarial medications that includes artemisinin . The second medication may be either mefloquine , lumefantrine , or sulfadoxine/pyrimethamine. Quinine , along with doxycycline , may be used if artemisinin

6528-475: The disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial resistance disappears over months to years if the person has no continuing exposure to malaria. The mosquito vector is itself harmed by Plasmodium infections, causing reduced lifespan. Human malaria is caused by single-celled microorganisms of the Plasmodium group. It

6630-673: The disease-resistant first. Sir John Kirk felt that in habit Ensete livingstonianum was indistinguishable from E. ventricosum and noted that both are found in the mountains of equatorial Africa. Malaria Malaria is a mosquito-borne infectious disease that affects vertebrates and Anopheles mosquitoes. Human malaria causes symptoms that typically include fever , fatigue , vomiting , and headaches . In severe cases, it can cause jaundice , seizures , coma , or death . Symptoms usually begin 10 to 15 days after being bitten by an infected Anopheles mosquito . If not properly treated, people may have recurrences of

6732-462: The disease. Females of the mosquito genus Anopheles prefer to feed at night. They usually start searching for a meal at dusk, and continue through the night until they succeed. However, in Africa, due to the extensive use of bed nets, they began to bite earlier, before bed-net time. Malaria parasites can also be transmitted by blood transfusions , although this is rare. Symptoms of malaria can recur after varying symptom-free periods. Depending upon

6834-591: The eastern edge of the Great African Plateau , extending northwards from South Africa through Mozambique, Zimbabwe, Malawi, Kenya, Uganda and Tanzania to Ethiopia, and west to the Congo, being found in high-rainfall forests on mountains, and along forested ravines and streams. Like bananas, Ensete ventricosum is a large non-woody plant—a gigantic monocarpic evergreen perennial (not a tree) —up to 6 m (20 ft) tall. The tallest to be reported

6936-407: The enset-growing regions. This contributes to the high number of varieties. Over centuries, the different ethnic groups have applied their specific indigenous knowledge of farming systems in order to sustain production in various ways. A dying out of enset varieties would hence also make disappear a part of cultural practices and linguistic terms in Ethiopia (Negash et al., 2004). Enset biodiversity

7038-494: The eyes to turn together in the same direction), opisthotonus , seizures , or coma . Diagnosis based on skin odor profiles Humans emanate a large range of smells. Studies have been conducted on how to detect human malaria infections through volatile compounds from the skin - suggesting that volatile biomarkers may be a reliable source for the detection of infection, including those asymptomatic. Using skin body odor profiles can be efficient in diagnosing global populations, and

7140-535: The false banana as an important household food security reserve. Even though not all the plant losses can be attributed to drought and land shortage and hence early consumption of immature crops, estimations go as far as more than 60% of the false banana crop stands have been lost in some areas in SNNPR during the last 10 years. This basically means that a great many people who used to close the food gap with false banana consumption are not able to do so any more, and lacking

7242-407: The field during this process. As women are responsible to provide sufficient food to their family, they are the ones who choose when and which plant to harvest and which quantity to sell. Several studies state the importance of women's knowledge on the different crop varieties. Women are more likely to precisely recognize the different varieties of the plant than men. Nevertheless, women's work

7344-442: The frequency with which malaria parasites complete their life cycle in the cell. Individuals who are homozygous (with two copies of the abnormal haemoglobin beta allele ) have sickle-cell anaemia , while those who are heterozygous (with one abnormal allele and one normal allele) experience resistance to malaria without severe anaemia. Although the shorter life expectancy for those with the homozygous condition would tend to disfavour

7446-466: The fruits are inedible ( insipid , flavorless) and have hard, black, rounded seeds. The Latin specific epithet ventricosum means “with a swelling on the side, like a belly”. Enset is a very important local food source especially in Ethiopia. The Food and Agriculture Organization of the United Nations reports that "enset provides more amount of foodstuff per unit area than most cereals. It

7548-399: The highest attractiveness to anthropophilic mosquitoes. Some of these studies have included traps that had been baited with nylon socks previously worn by human participants and were deemed efficient in catching adult mosquitos. Foot odors have high numbers of volatile compounds, which in turn elicit an olfactory response from mosquitoes. Malaria has several serious complications , including

7650-429: The home, and an increase in mosquitoes that are resistant to insecticides. Modifications to people's houses to prevent mosquito exposure may be an important long term prevention measure. Mosquito nets help keep mosquitoes away from people and reduce infection rates and transmission of malaria. Nets are not a perfect barrier and are often treated with an insecticide designed to kill the mosquito before it has time to find

7752-423: The infection of red blood cells. Symptoms develop once there are more than around 100,000 parasites per milliliter of blood. Many of the symptoms associated with severe malaria are caused by the tendency of P. falciparum to bind to blood vessel walls, resulting in damage to the affected vessels and surrounding tissue. Parasites sequestered in the blood vessels of the lung contribute to respiratory failure . In

7854-502: The initial symptoms and is often seen in P. vivax and P. ovale infections. P. vivax malaria cases in temperate areas often involve overwintering by hypnozoites, with relapses beginning the year after the mosquito bite. Reinfection means that parasites were eliminated from the entire body but new parasites were then introduced. Reinfection cannot readily be distinguished from relapse and recrudescence, although recurrence of infection within two weeks of treatment ending

7956-634: The liver undetected by wrapping itself in the cell membrane of the infected host liver cell. Within the red blood cells, the parasites multiply further, again asexually, periodically breaking out of their host cells to invade fresh red blood cells. Several such amplification cycles occur. Thus, classical descriptions of waves of fever arise from simultaneous waves of merozoites escaping and infecting red blood cells. Some P. vivax sporozoites do not immediately develop into exoerythrocytic-phase merozoites, but instead, produce hypnozoites that remain dormant for periods ranging from several months (7–10 months

8058-482: The main transport vectors are unclean working tools and the usage of already infected suckers. This means that the best way to get rid of the bug and to limit its propagation is to uproot the plant and burn it. In addition, the fields can be kept free of plant growth for a month since the mealybug can only survive up to three weeks without plant material. Other pests include nematodes , spider mites , aphids , mole rats , porcupines and wild pigs. The latter erode

8160-458: The mealybug occurs through different vectors: First, the larvae can crawl short distances as adults mealybugs tend to move only after being disturbed. Second, mealybugs -ant symbiotic relationships can be linked to enset infestation and protect and even transport the mealybug over short distances. In return, they feed on the mealybug honeydew. Third, flooding events can transport the mealybug over longer distances and reach enset plants. However,

8262-431: The metabolism of glycerol, lactic acid, amino acids, and lipids - through the action of bacteria found within the skin. They create a “chemical signature” for the mosquitoes to locate a potential host, humans in particular. Lactic acid Lactic acid, a naturally produced levorotatory isomer, has been titled an attractant of mosquitoes for a long time. Lactic acid is predominantly produced by eccrine-sweat glands, creating

8364-504: The modified haemoglobin S molecules are exposed to low amounts of oxygen, or crowd together due to dehydration, they can stick together forming strands that cause the cell to distort into a curved sickle shape. In these strands, the molecule is not as effective in taking or releasing oxygen, and the cell is not flexible enough to circulate freely. In the early stages of malaria, the parasite can cause infected red cells to sickle, and so they are removed from circulation sooner. This reduces

8466-489: The other hand, beginning in the early 1960s the inhabitants started to grow eucalyptus on an increasing scale, which has increased the amount of land being covered with trees. This region has 783 kilometers of all-weather roads and 281 kilometers of dry-weather roads, for an average road density of 182 kilometers per 1000 square kilometers. The Central Statistical Agency (CSA) reported that 7,624 tons of coffee were produced in Gurage, Hadiya and Kembata Tembaro combined in

8568-637: The parasite eventually disappears from that area, as happened in North America, Europe, and parts of the Middle East. However, unless the parasite is eliminated from the whole world, it could re-establish if conditions revert to a combination that favors the parasite's reproduction. Furthermore, the cost per person of eliminating anopheles mosquitoes rises with decreasing population density, making it economically unfeasible in some areas. Prevention of malaria may be more cost-effective than treatment of

8670-460: The plants. Other diseases have been observed such as Okka and Woqa which occur respectively in case of severe drought and in situations of too much water in the soil which causes the proliferation of bacteria. These problems can be solved by either watering the field when drought is present or by draining the soil to avoid too much water. Another disease can strike enset even though it has been more observed on Banana plants ( Musacea ). This disease

8772-425: The population, 5.28% spoke Amharic , 4.09% spoke Libido , 3.2% spoke Kebena , 2.98% spoke Silt'e , and 1.06% spoke Oromo ; the remaining 2.85% spoke all other primary languages reported. The majority of the inhabitants were reported as Muslim , with 51.91% of the population reporting that belief, while 41.02% practised Ethiopian Orthodox Christianity , 5.79% were Protestants , and 1.12% Catholic . According to

8874-456: The prevention of bites. As of 2023, there are two malaria vaccines , approved for use in children by the WHO: RTS,S and R21 . The presence of malaria in an area requires a combination of high human population density, high Anopheles mosquito population density and high rates of transmission from humans to mosquitoes and from mosquitoes to humans. If any of these is lowered sufficiently,

8976-409: The remaining 6.95% spoke all other primary languages reported. The majority of the inhabitants were reported as Muslim , with 62.97% of the population reporting that belief, while 33.98% practised Ethiopian Orthodox Christianity , 1.9% were Protestants , and 0.95% Catholic . According to a May 24, 2004 World Bank memorandum, 3% of the inhabitants of Gurage have access to electricity, this zone has

9078-411: The richest (71%) and the poorest (53%) households. Malaria is usually confirmed by the microscopic examination of blood films or by antigen -based rapid diagnostic tests (RDT). Microscopy—i.e. examining Giemsa -stained blood with a light microscope —is the gold standard for malaria diagnosis. Microscopists typically examine both a "thick film" of blood, allowing them to scan many blood cells in

9180-437: The screening and monitoring of infection to officially eradicate malaria. Research findings have predominantly relied on chemical explanations to explain the differences in attractiveness among humans based on distinct odor profiles. The existence of volatile compounds, like fatty acids, and lactic acid is an essential reason on why some individuals are more appealing to mosquitos than others. Volatile compounds Kanika Khanna,

9282-478: The seeds had germinated and the plants had rapidly gained size, their relationship to the true banana became obvious. Bruce also discussed the plant's place in the mythology of Egypt and pointed out that some Egyptian statue carvings depict the goddess Isis sitting among the leaves of what was thought to be a banana plant, a plant native to Southeast Asia and not known in Ancient Egypt. A major issue with

9384-641: The seventeenth century. Each plant takes four to five years to mature, at which time a single root will yield about 40 kg (88 lb) of food. Because of the long period of time from planting to harvest, plantings need to be staggered over time, to ensure that there is enset available for harvest in every season. Enset will tolerate drought better than most cereal crops . Wild enset plants are produced from seeds , while most domesticated plants are propagated from suckers . Up to 400 suckers can be produced from just one mother plant. In 1994 3,000 km (1,200 sq mi) of enset were grown in Ethiopia, with

9486-563: The spleen. The blockage of the microvasculature causes symptoms such as those in placental malaria. Sequestered red blood cells can breach the blood–brain barrier and cause cerebral malaria. Due to the high levels of mortality and morbidity caused by malaria—especially the P. falciparum species—it has placed the greatest selective pressure on the human genome in recent history. Several genetic factors provide some resistance to it including sickle cell trait , thalassaemia traits, glucose-6-phosphate dehydrogenase deficiency , and

9588-419: The starchy staple food prepared from the pulverised trunk and inflorescence stalk. Fermenting these pulverised parts results in a food called kocho . Bulla is made from the liquid squeezed out of the mixture and sometimes eaten as a porridge, while the remaining solids are suitable for consumption after a settling period of some days. Mixed kocho and bulla can be kneaded into dough, then flattened and baked over

9690-612: The trait's survival, the trait is preserved in malaria-prone regions because of the benefits provided by the heterozygous form. Liver dysfunction as a result of malaria is uncommon and usually only occurs in those with another liver condition such as viral hepatitis or chronic liver disease . The syndrome is sometimes called malarial hepatitis . While it has been considered a rare occurrence, malarial hepatopathy has seen an increase, particularly in Southeast Asia and India. Liver compromise in people with malaria correlates with

9792-415: The urine with kidney failure may occur. Complications may include spontaneous bleeding, coagulopathy , and shock . Malaria during pregnancy can cause stillbirths , infant mortality , miscarriage , and low birth weight , particularly in P. falciparum infection, but also with P. vivax . Malaria is caused by infection with parasites in the genus Plasmodium . In humans, malaria

9894-424: The urine , retinal damage , and convulsions . The classic symptom of malaria is paroxysm —a cyclical occurrence of sudden coldness followed by shivering and then fever and sweating, occurring every two days ( tertian fever ) in P. vivax and P. ovale infections, and every three days ( quartan fever ) for P. malariae . P. falciparum infection can cause recurrent fever every 36–48 hours, or

9996-401: The vast majority of malaria deaths), P. vivax , and P. knowlesi (a simian malaria that spills over into thousands of people a year). P. ovale and P. malariae generally cause a milder form of malaria. Malaria is typically diagnosed by the microscopic examination of blood using blood films , or with antigen-based rapid diagnostic tests . Methods that use

10098-427: The world where malaria is common were protected by an ITN. That number increased to 20.3 million (18.5%) African children using ITNs in 2007, leaving 89.6 million children unprotected and to 68% African children using mosquito nets in 2015. The percentage of children sleeping under ITNs in sub-Saharan Africa increased from less than 40% in 2011 to over 50% in 2021. Most nets are impregnated with pyrethroids ,

10200-533: The year ending in 2005, based on inspection records from the Ethiopian Coffee and Tea authority. This represented 7.6% of the Southern Nations, Nationalities and Peoples' Region (SNNPR)'s output and 3.36% of Ethiopia's total output. Following a referendum held between 18 and 26 April 2001, the Silt'e unanimously voted to form their own region, Silt'e. Based on the 2007 census conducted by

10302-432: The zone is exposed to malaria , and 38% to Tsetse fly . The memorandum gave this zone a drought risk rating of 319. 8°10′N 38°15′E  /  8.167°N 38.250°E  / 8.167; 38.250 Enset Ensete ventricosum , commonly known as enset or ensete , Ethiopian banana , Abyssinian banana , pseudo-banana , false banana and wild banana , is a species of flowering plant in

10404-598: Was 42 feet (13 meters). It has a stout pseudostem of tightly overlapping leaf bases, and large banana-like leaf blades of up to 5 m (16 ft) tall by 1 m (3 ft 3 in) wide, with a salmon-pink midrib. A mature plant weighs about 550 pounds (250 kilograms). The flowers, which only occur once from the centre of the plant at the end of that plant's life,( monocarpic ) are in massive pendant thyrsesup to ten feet ( three meters) in length bearing thirty or more "hands" of young bananas which are covered by large pink bracts . The roots are an important foodstuff, but

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