The Kalbelia are a snake charming tribe from the Thar Desert in Rajasthan , India. The dance is an integral part of their culture and performed by men and women.
143-475: Kalbelias are followers of Sage Kanifnath, who drank a bowl of poison and was blessed with control over venomous snakes and animals. Kalbelias are divided in two main groups, the Daliwal and Mewara. The Kalbelias moved frequently from one place to another in ancient times. Their traditional occupation is catching snakes and trading snake venom . They rear snakes, dogs, hens, horses, donkeys, pigs and goats. Hence,
286-465: A celebration, is an integral part of Kalbelia culture. Their dances and songs are a matter of pride and a marker of identity for the Kalbelias, as they represent the creative adaptation of this community of snake charmers to changing socio-economic conditions and their own role in rural Rajasthani society. The dancers are women in flowing black skirts who dance and twirl, replicating the movements of
429-479: A circuitous route repeated over time. Over the generations, the Kalbelias acquired a unique understanding of the local flora and fauna, and are aware of herbal remedies for various diseases which, in turn, is an alternative source of income for them. Since the enactment of the Wildlife Act of 1972 , the Kalbelias have been pushed out of their traditional profession of snake handling. Now performing arts are
572-449: A considerable time. Differences in fang length between the various venomous snakes are likely due to the evolution of different striking strategies. Additionally, it has been shown that the fangs of different species of venomous snakes have different sizes and shapes depending on the biomechanical properties of the snake's prey. Spitting cobras of the genera Naja and Hemachatus , when irritated or threatened, may eject streams or
715-418: A difference in regard to sensitive measurements such as purity. The big drawback has to do with the economics. Although the method offered efficient, acquiring the necessary equipment was difficult. Large machinery is necessary, and for a long time, the lack of equipment availability limited its widespread use. Venom evolved just once among all Toxicofera about 170 million years ago, and then diversified into
858-465: A diluent. For example, fraction V produces about 95% purified albumin (dried crude venom). Saline as a diluent consistently produces widely varying LD 50 results for nearly all venomous snakes. It produces unpredictable variation in precipitate purity (35-60%). Fraction V is structurally stable because it has seventeen disulfide bonds ; it's unique in that it has the highest solubility and lowest isoelectric point of major plasma proteins. This makes it
1001-459: A few days recovery usually occurs somewhat suddenly, but death may result from the severe depression or from the secondary effects of suppuration . That cases of death, in adults as well as in children, are not infrequent in some parts of the Continent is mentioned in the last chapter of this Introduction. The Viperidae differ much among themselves in the toxicity of their venoms. Some, such as
1144-508: A few fatalities were on record, until 1957, the possibility that such snakes were deadly to humans seemed at most remote. The deaths of two prominent herpetologists, Robert Mertens and Karl Schmidt , from African colubrid bites, changed that assessment, and recent events reveal that several other species of rear-fanged snakes have venoms that are potentially lethal to large vertebrates. Boomslang ( Dispholidus typus ) and twig snake ( Thelotornis spp.) venoms are toxic to blood cells and thin
1287-455: A high priority for scientists in terms of scientific research, due to the medical relevance of snake venom, in terms of making antivenom and cancer research. Knowing more about the composition of venom and the ways it can potentially evolve is very beneficial. Three main factors that affect venom evolution have been closely studied: predators of the snake that are resistant to snake venom, prey that are in an evolutionary arms race with snakes, and
1430-472: A large area within the districts of Kota and Bundi forms a tableland. To the northeast of these districts is a rugged region (badlands) following the line of the Chambal River . Farther north the country levels out; the flat plains of the northeastern Bharatpur district are part of an alluvial basin. Merta City lies in the geographical center of Rajasthan. The Aravalli Range and the lands to
1573-661: A large portion of Rajasthan. The indomitable Rana Kumbha defeated the Sultans of Malwa , Nagaur and Gujarat and made Mewar the most powerful Rajput Kingdom in India. The ambitious Rana Sanga united the various Rajput clans, including the Muslim Khanzadas of Mewat under Raja Hasan Khan Mewati , and fought against the foreign powers in India. Rana Sanga defeated the Afghan Lodi Empire of Delhi and crushed
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#17327831761581716-462: A major source of income for them and these have received widespread recognition within and outside India. Opportunities for performance are sporadic, and also depend on tourism, which is season specific, so members of the community work in the fields, or graze cattle to sustain themselves. The Kalbelias are Cultural Hindus and practice snake worship ; they worship the Nāga and Manasa , and their holy day
1859-416: A method to track down prey after a bite. Though venom function has evolved to be specific to prey class (e.g. particular coagulatory effects), the evolution of broad toxicological effects (e.g. neurotoxicity or coagulotoxicity) does not appear to be broadly affected by prey type. The presence of digestive enzymes in snake venom was once believed to be an adaptation to assist digestion. However, studies of
2002-570: A non-enzymatic mechanism that leads to severe skeletal muscle necrosis . These peptides act very quickly, causing instantaneous paralysis to prevent prey from escaping and eventually death due to diaphragmatic paralysis. The first myotoxin to be identified and isolated was crotamine , discovered in the 1950s by Brazilian scientist José Moura Gonçalves from the venom of tropical South American rattlesnake Crotalus durissus terrificus . Its biological actions, molecular structure and gene responsible for its synthesis were all elucidated in
2145-412: A per capita GDP of ₹ 118,000 (US$ 1,400). Rajasthan ranks 22nd among Indian states in human development index . Rajasthan means "The Land of Kings" and is a portmanteau of Sanskrit "Rājā" ('King') and Sanskrit "Sthāna" ('Land') or Persian "St(h)ān", with the same meaning. The oldest reference to Rajasthan is found in a stone inscription dated back to 625 CE. The first printed mention of
2288-532: A remnant of the primitive Sarasvati river . The Desert National Park in Jaisalmer , spread over an area of 3,162 square kilometres (1,221 sq mi), is an excellent example of the ecosystem of the Thar Desert and its diverse fauna . Seashells and massive fossilised tree trunks in this park record the geological history of the desert. The region is a haven for migratory and resident birds of
2431-518: A reputation for composing lyrics spontaneously and improvising songs during performances. These songs and dances are part of an oral tradition that is handed down generations and for which there are neither texts nor any training manuals. In 2010, the Kalbelia folk songs and dances of Rajasthan were declared a part of its Intangible Heritage List by the UNESCO . Snake venom Snake venom
2574-434: A serpent. They wear an upper body cloth called an angrakhi and a headcloth known as the odhani ; the lower body cloth is called a lehenga . All these clothes are of mixed red and black hues and embroidered. The male participants play musical instruments, such as the pungi , a woodwind instrument traditionally played to capture snakes, the dufli , been , the khanjari - a percussion instrument, morchang , khuralio and
2717-486: A spray of venom a distance of 1.2 metres (4 ft) to 2.4 metres (8 ft). These snakes' fangs have been modified for the purposes of spitting; inside the fangs, the channel makes a 90° bend to the lower front of the fang. Spitters may spit repeatedly and still be able to deliver a fatal bite. Spitting is a defensive reaction only. The snakes tend to aim for the eyes of a perceived threat. A direct hit can cause temporary shock and blindness through severe inflammation of
2860-405: Is Naga Panchami . The Kalbelias have different traditions from the majority of Hindus. The Kalbelia men wear a Apadravya . Kalbelias bury their dead, instead of cremating them (as is common with Hindus in the rest of the country). The groom has to pay the bride's father a price for the bride and the groom's father has to pay for the wedding. The Kalbelia dance, folk dance of rajasthan performed as
3003-443: Is a highly toxic saliva containing zootoxins that facilitates in the immobilization and digestion of prey . This also provides defense against threats. Snake venom is usually injected by unique fangs during a bite , though some species are also able to spit venom . The venom glands that secrete zootoxins are a modification of the parotid salivary glands found in other vertebrates and are usually located on each side of
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#17327831761583146-462: Is a purified plasma component for injection or transfusion , the plasma component must be highly pure. The first practical large-scale method of blood plasma fractionation was developed by Edwin J. Cohn during World War II . it's known as the Cohn process (or Cohn method). This process is also known as cold ethanol fractionation, as it involves gradually increasing the concentration of ethanol in
3289-752: Is also undertaken in Rajasthan. Jodhpur sandstone is mostly used in monuments, important buildings, and residential buildings. This stone is termed as Chittar Patthar . Jodhpur leads in the handicraft and guar gum industries. Rajasthan is also a part of the Mumbai-Delhi Industrial corridor set to benefit economically. The state gets 39% of the DMIC, with major districts of Jaipur, Alwar, Kota and Bhilwara benefiting. Rajasthan also has reserves of low-silica limestone. Rajasthan connected 100% of its population to electricity power in 2019 (raising
3432-701: Is appointed by the President of India for a five-year term. The leader of the party or coalition with a majority in the Legislative Assembly is appointed as the chief minister by the governor, and the council of ministers are appointed by the governor on the advice of the chief minister . The governor remains a ceremonial head of the state, while the chief minister and his council are responsible for day-to-day government functions. The council of ministers consists of Cabinet Ministers , Ministers of State (MoS) and Deputy Ministers. The Secretariat headed by
3575-813: Is composed of the following geographical regions: Rajasthan is divided into 50 districts within Ten divisions : A district collector or district magistrate , who is appointed by either the Indian Administrative Service or the Rajasthan Public Service Commission , governs each district. Subdivisions (Tehsils) are responsible for governing districts and are overseen by sub-divisional magistrates. Additionally, districts are further divided into blocks. A block consists of panchayats (village councils) and town municipalities. Tehsils are intermediate level panchayat between
3718-621: Is drained by the Banas and Chambal rivers, tributaries of the Ganges . The northwestern portion of Rajasthan is generally sandy and dry. Most of this region is covered by the Thar Desert which extends into adjoining portions of Pakistan. The Aravalli Range does not intercept the moisture-giving southwest monsoon winds off the Arabian Sea , as it lies in a direction parallel to that of
3861-479: Is formulated with combinations of sodium octanoate and sodium N-acetyl tryptophanate and then subjected to viral inactivation procedures, including pasteurization at 60 °C. This is a more efficient alternative than the Cohn process because: Compared with the Cohn process, albumin purity increased from about 95% to 98% using chromatography, and the yield increased from about 65% to 85%. Small percentage increases make
4004-484: Is geographical and ontogenic. Phosphodiesterases interfere with the prey's cardiac system, mainly to lower the blood pressure . Phospholipase A2 causes hemolysis by lysing the phospholipid cell membranes of red blood cells . Amino acid oxidases and proteases are used for digestion. Amino acid oxidase also triggers some other enzymes and is responsible for the yellow colour of the venom of some species. Hyaluronidase increases tissue permeability to accelerate
4147-694: Is headed by a District Magistrate/District Collector, who is also an IAS officer, and is assisted by a number of officers belonging to Rajasthan Administrative Services . In Rajasthan, the police force is led by an IPS officer holding the position of Director General of Police . Each district is supervised by a Superintendent of Police , also an IPS officer, who is supported by officers from the Rajasthan Police Services. Their primary responsibility involves maintaining law and order and addressing relevant issues within their respective districts. The management of forests, environment, and wildlife in
4290-477: Is how to deliver protein to the nerve cells: proteins usually are not applicable as pills. The question whether individual snakes are immune to their own venom has not yet been definitively settled, though an example is known of a cobra that self-envenomated, resulting in a large abscess requiring surgical intervention, but showing none of the other effects that would have proven rapidly lethal in prey species or humans. Furthermore, certain harmless species, such as
4433-450: Is mainly on the nervous system , respiratory paralysis being quickly produced by bringing the venom into contact with the central nervous mechanism that controls respiration; the pain and local swelling that follow a bite are not usually severe. The bite of all the proteroglyphous elapids, even of the smallest and gentlest, such as the coral snakes , is, so far as known, deadly to humans. However, some mildly venomous elapids remain, such as
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4576-454: Is mardi gras ( Renealmia alpinia ) (berries), which are crushed together with the juice of wild cane ( Costus scaber ) and given to the bitten. Quick fixes have included applying chewed tobacco from cigarettes, cigars, or pipes. Making cuts around the puncture or sucking out the venom had been thought helpful in the past, but this course of treatment is now strongly discouraged, due to the risk of self-envenomation through knife cuts or cuts in
4719-623: Is not so direct; the influence upon the circulation explains the great depression, which is a symptom of viperine envenomation. The pain of the wound is severe and is rapidly followed by swelling and discoloration. The symptoms produced by the bite of the European vipers are thus described by Martin and Lamb: The bite is immediately followed by the local pain of a burning character; the limb soon swells and becomes discolored, and within one to three hours great prostration, accompanied by vomiting , and often diarrhea , sets in. Cold, clammy perspiration
4862-599: Is on India's northwestern side, where it comprises most of the wide and inhospitable Thar Desert (also known as the Great Indian Desert) and shares a border with the Pakistani provinces of Punjab to the northwest and Sindh to the west, along the Sutlej - Indus River valley. It is bordered by five other Indian states: Punjab to the north; Haryana and Uttar Pradesh to the northeast; Madhya Pradesh to
5005-416: Is one of the largest airbases in India, BSF and Military bases are also situated here. Currently four civil airports are located here: Jodhpur, Jaisalmer, Bikaner and Nagaur, of which Jodhpur is the major civil airport, being the 44th busiest airport in India and one of the oldest air strips of India, being built in the 1920s. The Northwestern thorn scrub forests lie in a band around the Thar Desert, between
5148-412: Is purified albumin. Several variations to this process exist, including an adapted method by Nitschmann and Kistler that uses fewer steps, and replaces centrifugation and bulk freezing with filtration and diafiltration. Some newer methods of albumin purification add additional purification steps to the Cohn process and its variations. Chromatographic albumin processing emerged in the 1980s, however, it
5291-564: Is responsible for maintaining and expanding the state highways system and major district roads. Jaipur–Kishangarh Expressway forms a segment of the NH-8 which is a part of the Golden Quadrilateral project. Rajasthan State Road Transport Corporation (RSRTC) was established in 1964 to provide economical and reliable passenger road transport service in the state with connecting services to adjoining states. For travelling locally,
5434-442: Is the first metro in India to run on triple-storey elevated road and metro track. The state is served by a substantial road network, providing links between urban centers, agricultural market-places and rural areas. There are 33 national highways (NH) in the state, covering a total distance of 10,004.14 km (6,216.28 mi). The state has a total road length of 269,028 km (167,166 mi). The Department of Public Works
5577-493: Is the state's largest, busiest and only international airport. Jaipur International Airport offers international service to Dubai , Bangkok , Sharjah and Muscat . There are five civilian airports in Rajasthan including Jodhpur Airport , Udaipur Airport , Ajmer Airport , Bikaner Airport and Jaisalmer Airport . Domestic airports are operated by the Airports Authority of India (AAI) and shares its airside with
5720-524: Is true even for members of one species. Such variation is smaller in captive populations in laboratory settings, though it cannot be eliminated. However, studies to determine snake venom potency must be designed to minimize variability. Several techniques have been designed to this end. One approach is to use 0.1% bovine serum albumin (also known as "fraction V" in Cohn process ) as a diluent in determining LD 50 values. It results in more accurate and consistent LD 50 determinations than using 0.1% saline as
5863-473: Is usual. The pulse becomes extremely feeble, and slight dyspnoea and restlessness may be seen. In severe cases, which occur mostly in children, the pulse may become imperceptible and the extremities cold; the patient may pass into coma . In from twelve to twenty-four hours these severe constitutional symptoms usually pass off; but in the meantime, the swelling and discoloration have spread enormously. The limb becomes phlegmonous and occasionally suppurates. Within
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6006-421: Is very large and is surrounded by the masseter or temporal muscle , which consists of two bands, the superior arising from behind the eye, the inferior extending from the gland to the mandible. A duct carries venom from the gland to the fang. In vipers and elapids, this groove is completely closed, forming a hypodermic needle-like tube. In other species, the grooves are not covered, or only partially covered. From
6149-537: The Aravalli Range , which runs through the state from southwest to northeast, almost from one end to the other, for more than 850 kilometres (530 mi). Mount Abu lies at the southwestern end of the range, separated from the main ranges by the West Banas River . Although a series of broken ridges continues into Haryana in the direction of Delhi where it can be seen as outcrops in the form of
6292-537: The First Battle of Tarain in 1191. In 1192 CE, Muhammad Ghori decisively defeated Prithviraj at the Second Battle of Tarain . After the defeat of Chauhan in 1192 CE, a part of Rajasthan came under Muslim rulers. The principal centers of their powers were Nagaur and Ajmer. Ranthambhore was also under their suzerainty. At the beginning of the 13th century, the most prominent and powerful state of Rajasthan
6435-572: The North American common kingsnake ( Lampropeltis getula ) and the Central and South American mussurana ( Clelia spp.), are proof against the venom of the crotalines , which frequent the same districts, and which they are able to overpower and feed upon. The chicken snake ( Spilotes pullatus ) is the enemy of the fer-de-lance ( Bothrops caribbaeus ) in St. Lucia, and in their encounters,
6578-536: The Raisina Hill and the ridges farther north. About three-fifths of Rajasthan lies northwest of the Aravallis, leaving two-fifths on the east and south direction. The Aravalli Range runs across the state from the southwest peak Guru Shikhar (Mount Abu), which is 1,722 metres (5,650 ft) in height, to Khetri in the northeast. This range divides the state into 60% in the northwest of the range and 40% in
6721-642: The Saka rulers of the western part of India, were successors to the Indo-Scythians and were contemporaneous with the Kushans , who ruled the northern part of the Indian subcontinent . The Indo-Scythians invaded the area of Ujjain and established the Saka era (with their calendar ), marking the beginning of the long-lived Saka Western Satraps state. The Pratiharas ruled for many dynasties in this part of
6864-575: The Shekhawati region. This sanctuary is home to a large population of blackbuck . Desert foxes and the caracal , an apex predator , also known as the desert lynx , can also be spotted, along with birds such as the partridge , harriers , eastern imperial eagle , pale harrier , marsh harrier , short-toed eagle , tawny eagle , sparrow hawk , crested lark , demoiselle crane , skylarks , green bee-eater , brown dove , black ibis , and sand grouse . The great Indian bustard , known locally as
7007-486: The Zilla Parishad (district councils) at the district level and gram panchayat (village councils) at the lower level. Rajasthan has 5 cities with over one million population. The absolute urban population of the state is 17.4 million, which constitutes 24.87% of the total urban population of the state. There are 10 municipal corporations , 34 municipal councils and 172 municipal boards or nagar pachayats in
7150-445: The cobra and advocate the non-killing of such reptiles. In the villages, if a snake inadvertently happened to enter a home, a Kalbelia would be summoned to catch the serpent and to take it away without killing it. Kalbelias have traditionally been a fringe group in the society, living in spaces outside the village where they reside. They live in makeshift camps called deras . The Kalbelias move their deras from one place to another in
7293-499: The cornea and conjunctiva . Although usually no serious symptoms result if the venom is washed away immediately with plenty of water, blindness can become permanent if left untreated. Brief contact with the skin is not immediately dangerous, but open wounds may be vectors for envenomation. The four distinct types of venom act on the body differently: The effect of the venom of proteroglyphous snakes ( sea snakes , kraits , mambas , black snakes , tiger snakes , and death adders )
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#17327831761587436-429: The dholak to create the rhythm on which the dancers perform. The dancers are tattooed in traditional designs and wear jewelry and garments richly embroidered with small mirrors and silver threads. As the performance progresses, the rhythm becomes faster and faster and so does the dance. Kalbelia songs are based on stories taken from folklore and mythology and special dances are performed during Holi . The Kalbelias have
7579-489: The godavan , and which is a state bird, has been classed as critically endangered since 2011. Rajasthan is also noted for its national parks and wildlife sanctuaries. There are four national parks and wildlife sanctuaries: Keoladeo National Park of Bharatpur , Sariska Tiger Reserve of Alwar, Ranthambore National Park of Sawai Madhopur , and Desert National Park of Jaisalmer. A national-level institute, Arid Forest Research Institute (AFRI) an autonomous institute of
7722-411: The maxilla , where a small posterior portion of the upper labial or salivary gland produces venom. Several genera, including Asian coral snakes ( Calliophis ), burrowing asps ( Atractaspis ), and night adders ( Causus ), are remarkable for having exceptionally long venom glands, extending along each side of the body, in some cases extending posterially as far as the heart. Instead of the muscles of
7865-573: The parotid gland of Rhabdophis and Zamenis have shown that even aglyphous snakes are not entirely devoid of venom, and point to the conclusion that the physiological difference between so-called harmless and venomous snakes is only one of degree, just as various steps exist in the transformation of an ordinary parotid gland into a venom gland or of a solid tooth into a tubular or grooved fang. Given that snake venom contains many biologically active ingredients, some may be useful to treat disease. For instance, phospholipases type A2 (PLA2s) from
8008-412: The pig may be considered immune is still uncertain, though early studies show endogenous resistance in pigs tested against neurotoxins. Though the pig's subcutaneous layer of fat may protect it against snake venom, most venoms pass easily through vascular fat layers, making this unlikely to contribute to its ability to resist venoms. The garden dormouse ( Eliomys quercinus ) has recently been added to
8151-425: The solution at 5 °C and 3 °C. The Cohn Process exploits differences in plasma proteins properties, specifically, the high solubility and low pI of albumin. As the ethanol concentration is increased in stages from 0 to 40%, the pH declines from neutral (pH ~ 7) to about 4.8, which is near the pI of albumin. At each stage, proteins are precipitated out of the solution and removed. The final precipitate
8294-404: The western diamondback rattlesnake ( Crotalus atrox ), a snake with highly proteolytic venom, show that venom has no impact on the time required for food to pass through the gut . These various adaptations of venom have also led to considerable debate about the definition of venom and venomous snakes. In vipers , which have the most highly developed venom-delivery apparatus, the venom gland
8437-775: The 1980s. Developments were ongoing between when Cohn fractionation started emerge in 1946, and when chromatography emerged, in 1983. In 1962, the Kistler and Nistchmann process was created as a spin-off of the Cohn process. In the 1990s, the Zenalb and the CSL Albumex processes were created, which incorporated chromatography with variations. The general approach to using chromatography for plasma fractionation for albumin is: recovery of supernatant I, delipidation, anion exchange chromatography , cation exchange chromatography, and gel filtration chromatography. The recovered purified material
8580-521: The British district of Ajmer-Merwara . Jaisalmer , Marwar (Jodhpur), Bikaner , Mewar (Chittorgarh), Alwar and Dhundhar (Jaipur) were some of the main Rajput princely states. Bharatpur and Dholpur were Jat princely states whereas Tonk was a princely state under Pathans . The three chiefships were Lawa, Neemrana and Kushalgarh. The geographic features of Rajasthan are the Thar Desert and
8723-582: The Chief Secretary assists the council of ministers. The Chief Secretary is also the administrative head of the government. Each government department is headed by a minister, who is assisted by an Additional Chief Secretary or a Principal Secretary, who is usually an officer of Indian Administrative Service (IAS), the Additional Chief Secretary/Principal Secretary serve as the administrative head of
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#17327831761588866-460: The Elapidae. Rajasthan Rajasthan ( / r ɑː dʒ ə ˈ s t ɑː n / ; Hindi: [raːdʒəsˈtʰaːn] ; lit. 'Land of Kings') is a state in northwestern India . It covers 342,239 square kilometres (132,139 sq mi) or 10.4 per cent of India's total geographical area. It is the largest Indian state by area and the seventh largest by population . It
9009-725: The Indian Air Force. These airports connect Rajasthan with the major cities of India such as Mumbai, Kolkata , Hyderabad , Chennai and Bangalore . Railways length in the state constitute 8.66 per cent of all India route length. Jaipur Junction is the headquarters of the North Western Railway . Jaipur, Ajmer , Bikaner are the busiest railway stations in the state. Kota is the only electrified section served by three Rajdhani Expresses and trains to all major cities of India. Jaipur Superfast Express , fastest train under Superfast category of trains; connects
9152-669: The Indian Russell's viper ( Daboia russelli ) and saw-scaled viper ( E. carinatus ); the American rattlesnakes ( Crotalus spp.), bushmasters ( Lachesis spp.), and lanceheads ( Bothrops spp.); and the African adders ( Bitis spp.), night adders ( Causus spp.), and horned vipers ( Cerastes spp.), cause fatal results unless a remedy is speedily applied. The bite of the larger European vipers may be very dangerous, and followed by fatal results, especially in children, at least in
9295-562: The Miami Serpentarium, injected himself with snake venom during most of his adult life, in an effort to build up an immunity to a broad array of venomous snakes, in a practice known as mithridatism . Haast lived to age 100, and survived a reported 172 snake bites. He donated his blood to be used in treating snake-bite patients when a suitable antivenom was not available. More than 20 so-treated individuals recovered. Amateur researcher Tim Friede also lets venomous snakes bite him in
9438-597: The Rajput kings accepted Mughal suzerainty, but the rulers of Mewar (Rana Udai Singh II ) and Marwar (Rao Chandrasen Rathore ) refused to have any form of alliance with the Mughals. To teach the Rajputs a lesson Akbar attacked Udai Singh and killed Rajput commander Jaimal of Chitor and the citizens of Mewar in large numbers. Akbar killed 20,000–25,000 unarmed citizens in Chittor on the grounds that they had actively helped in
9581-505: The Tunisian vipers Cerastes cerastes and Macrovipera lebetina have been found to have antitumor activity. Anticancer activity has been also reported for other compounds in snake venom. PLA2s hydrolyze phospholipids, thus could act on bacterial cell surfaces, providing novel antimicrobial (antibiotic) activities. The analgesic (pain-killing) activity of many snake venom proteins has been long known. The main challenge, however,
9724-607: The Turkic Sultanates of Malwa and Gujarat. Rana Sanga then tried to create an Indian empire but was defeated by the first Mughal Emperor Babur at Khanwa . The defeat was due to betrayal by the Tomar King Silhadi of Raisen. After Rana Sanga 's death, Marwar rose as a power center in Rajasthan under Rao Maldeo Rathore . He conquered Jaisalmer, parts of Gujarat, Jalore, Nagaur, Ajmer, Sanchore, Bhinmal, Radhanpur, Bayana, Tonk, Toda and Nabhara. He expanded
9867-408: The absorption of other enzymes into tissues. Some snake venoms carry fasciculins , like the mambas ( Dendroaspis ), which inhibit cholinesterase to make the prey lose muscle control. Snake toxins vary greatly in their functions. The two broad classes of toxins found in snake venoms are neurotoxins (mostly found in elapids) and hemotoxins (mostly found in viperids). However, exceptions occur –
10010-808: The ancient Aravalli mountain range and eastern Rajasthan, the Keoladeo National Park of Bharatpur , a World Heritage Site known for its bird life. Rajasthan is also home to three national tiger reserves, the Ranthambore National Park in Sawai Madhopur , Sariska Tiger Reserve in Alwar and the Mukundra Hills Tiger Reserve in Kota . The State of Rajasthan was formed on 30 March 1949 when
10153-407: The anterior extremity of the gland, the duct passes below the eye and above the maxillary bone , to the basal orifice of the venom fang, which is ensheathed in a thick fold of mucous membrane . By means of the movable maxillary bone hinged to the prefrontal bone and connected with the transverse bone, which is pushed forward by muscles set in action by the opening of the mouth, the fang is erected and
10296-475: The blood (hemotoxic, hemorrhagic). Early symptoms include headaches, nausea, diarrhea, lethargy, mental disorientation, bruising, and bleeding at the site and all body openings. Exsanguination is the main cause of death from such a bite. The boomslang's venom is the most potent of all rear-fanged snakes in the world based on LD 50 . Although its venom may be more potent than some vipers and elapids, it causes fewer fatalities owing to various factors (for example,
10439-568: The caterpillars ( Battus polydamas , Papilionidae) that eat tree leaves ( Aristolochia trilobata ). Emergency snake medicines are obtained by chewing a three-inch piece of the root of bois canôt ( Cecropia peltata ) and administering this chewed-root solution to the bitten subject (usually a hunting dog). This is a common native plant of Latin America and the Caribbean, which makes it appropriate as an emergency remedy. Another native plant used
10582-590: The chicken snake is invariably the victor. Repeated experiments have shown the European grass snake ( Natrix natrix ) not to be affected by the bite of the European adder ( Vipera berus ) and the European asp ( Vipera aspis ), this being due to the presence, in the blood of the harmless snake, of toxic principles secreted by the parotid and labial glands, and analogous to those of the venom of these vipers. Several North American species of rat snakes, as well as king snakes, have proven to be immune or highly resistant to
10725-443: The city of Kota , in southern Rajasthan. Rajasthan is pre-eminent in quarrying and mining in India. The Taj Mahal was built from white marble which was mined from a town called Makrana . The state is the second-largest source of cement in India. It has rich salt deposits at Sambhar , copper mines at Khetri , Jhunjhunu , and zinc mines at Dariba, Zawar mines and Rampura Agucha (opencast) near Bhilwara . Dimensional stone mining
10868-533: The coming monsoon winds, leaving the northwestern region in a rain shadow . The Thar Desert is thinly populated; the City of Jodhpur is the largest city in the desert and a major metropolitan area of India which is known as the gateway of the Thar desert. The desert has some major districts like Jodhpur , Jaisalmer, Barmer, Bikaner , and Nagaur . This area is also important from a defence point of view. Jodhpur airbase
11011-639: The commandants of Jodhpur and Bayana and recovered Amer by a night attack. They next killed Sayyid Hussain Khan Barha, the commandant of Mewat and many other Mughal officers. Bahadur Shah I , then in the Deccan was forced to patch up a truce with the Rajput Rajas. The Jats , under Suraj Mal , overran the Mughal garrison at Agra and plundered the city taking with them the two great silver doors of
11154-573: The country; the region was known as Gurjaratra . Up to the 10th century CE, almost all of North India acknowledged the supremacy of the Imperial Pratiharas, with their seat of power at Kannauj . The Gurjara Pratihar Empire acted as a barrier for Arab invaders from the 8th to the 11th century. The chief accomplishment of the Gurjara-Pratihara Empire lies in its successful resistance to foreign invasions from
11297-633: The dance movements and the costumes of their community bear a resemblance to those of the serpents. They are also called Sapera and Jogira, Gattiwala and Poogiwara. The largest cluster of the Kalbelias is in Pali district , followed by significant other groups in Ajmer , Chittorgarh and Udaipur district . They live a nomadic life and belong to the scheduled tribes . Traditionally, Kalbelia men carried cobras in cane baskets from door to door in villages while their women sang, danced and begged for alms. They revere
11440-481: The department they are assigned to. Each department also has officers of the rank of Secretary, Special Secretary, Joint Secretary etc. assisting the Minister and the Additional Chief Secretary/Principal Secretary. For the administration purpose, the state is divided into 10 divisions and 50 districts. Divisional Commissioner , is the head of administration on the divisional level. The administration in each district
11583-424: The desert and the Aravallis. This region receives less than 400 mm of rain annually. Temperatures can sometimes exceed 45 °C in the summer months and drop below freezing point in the winter. The Godwar , Marwar , and Shekhawati regions lie in the thorn scrub forest zone, along with the city of Jodhpur. The Luni River and its tributaries are the major river system of Godwar and Marwar regions, draining
11726-528: The desert. One can see many eagles , harriers , falcons , buzzards , kestrels and vultures . Short-toed snake eagles ( Circaetus gallicus ), tawny eagles ( Aquila rapax ), spotted eagles ( Aquila clanga ), laggar falcons ( Falco jugger ) and kestrels are some of the raptor species seen in Desert National Park. Road traffic inside the Park is, however, a threat to several wild species of
11869-1621: The digestion of prey, and various other substances are responsible for important but non-lethal biological effects. Some of the proteins in snake venom have very specific effects on various biological functions, including blood coagulation, blood pressure regulation, and transmission of nerve or muscle impulses. These venoms have been studied and developed for use as pharmacological or diagnostic tools, and even drugs. Proteins constitute 90-95% of venom's dry weight and are responsible for almost all of its biological effects. The hundreds, even thousands, of proteins found in venom include toxins, neurotoxins in particular, as well as nontoxic proteins (which also have pharmacological properties), and many enzymes, especially hydrolytic ones. Enzymes ( molecular weight 13-150 KDa) make up 80-90% of viperid and 25-70% of elapid venoms, including digestive hydrolases , L-amino-acid oxidase , phospholipases , thrombin -like pro-coagulant, and kallikrein -like serine proteases and metalloproteinases (hemorrhagins), which damage vascular endothelium . Polypeptide toxins (molecular weight 5-10 KDa) include cytotoxins , cardiotoxins , and postsynaptic neurotoxins (such as α-bungarotoxin and α-Cobratoxin ), which bind to acetylcholine receptors at neuromuscular junctions. Compounds with low molecular weight (up to 1.5 KDa) include metals, peptides, lipids, nucleosides , carbohydrates, amines, and oligopeptides , which inhibit angiotensin-converting enzyme (ACE) and potentiate bradykinin (BPP). Inter- and intra-species variation in venom chemical composition
12012-678: The district is overseen by the Divisional Forest Officer , who is a member of the Indian Forest Service . This responsibility is carried out with the assistance of officers from the Rajasthan Forest Service and Rajasthan Subordinate Service. Rajasthan has its High court Jodhpur which has its principal seat at Jodhpur and a bench at Jaipur , with district courts and session courts in each district or Sessions Division, and lower courts at
12155-501: The early 19th century, accepting British suzerainty and control over their external affairs in return for internal autonomy. The State of Rajasthan was formed on 30 March 1949 when the states of the Rajputana Agency of the erstwhile British Empire in India were merged into the new Indian Union . Modern Rajasthan includes most of Rajputana , which comprises the erstwhile nineteen princely states , three chiefships, and
12298-481: The east and southeast of the range are generally more fertile and better watered. This region is home to the Khathiar-Gir dry deciduous forests ecoregion, with tropical dry broadleaf forests that include teak , Acacia , and other trees. The hilly Vagad region, home to the cities of Dungarpur , Pratapgarh , and Banswara lies in southernmost Rajasthan, on the border with Gujarat and Madhya Pradesh . With
12441-532: The entrance of the famous Taj Mahal which were then melted down by Suraj Mal in 1763. Over the years, the Mughals began to have internal disputes which greatly distracted them at times. The Mughal Empire continued to weaken, and with the decline of the Mughal Empire in the late 18th century, Rajputana came under the influence of the Marathas . The Maratha Empire, which had replaced the Mughal Empire as
12584-589: The exception of Mount Abu, Vagad is the wettest region in Rajasthan, and the most heavily forested. North of Vagad lies the Mewar region, home to the cities of Udaipur and Chittaurgarh . The Hadoti region lies to the southeast, on the border with Madhya Pradesh. North of Hadoti and Mewar lies the Dhundhar region, home to the state capital of Jaipur . Mewat , the easternmost region of Rajasthan, borders Haryana and Uttar Pradesh . Eastern and southeastern Rajasthan
12727-402: The fangs' effectiveness is not high compared with many other snakes, the venom dose delivered is low, and boomslangs are generally less aggressive in comparison to other venomous snakes such as cobras and mambas). Symptoms of a bite from these snakes include nausea and internal bleeding, and one could die from a brain hemorrhage and respiratory collapse . Experiments made with the secretion of
12870-399: The final fraction to be precipitated from its solution. Bovine serum albumin is located in fraction V. The precipitation of albumin is done by reducing the pH to 4.8, near the pH of the proteins, and maintaining the ethanol concentration at 40%, with a protein concentration of 1%. Thus, only 1% of the original plasma remains in the fifth fraction. When the ultimate goal of plasma processing
13013-590: The finance capital of India Mumbai to Jaipur. Luxury tourist train Maharajas' Express runs across North-West and Central India, mainly centered on Rajasthan. There is also an international railway, the Thar Express from Jodhpur (India) to Karachi (Pakistan). However, this is not open to foreign nationals. Jaipur Metro is the metro rail system in the city of Jaipur. It is the only metro rail system in Rajasthan and has been operational since 3 June 2015. It
13156-455: The former state of Jaipur in Rajasthan and included the whole of Alwar with portions of Bharatpur. The capital of Matsya was at Viratanagar (modern Bairat), which is said to have been named after its founder King Virata . Bhargava identifies the two districts of Jhunjhunu and Sikar and parts of Jaipur district along with Haryana districts of Mahendragarh and Rewari as part of Vedic state of Brahmavarta . Bhargava also locates
13299-493: The head of the government and the head of the council of ministers. The Legislative Assembly consists of 200 members who are elected for five-year terms. The state contributes 25 seats to Lok Sabha , the lower house of the Indian Parliament, and 10 seats to Rajya Sabha , the upper house. The Government of Rajasthan is a democratically elected body in India with the governor as its constitutional head. Governor
13442-510: The head, below and behind the eye, and enclosed in a muscular sheath. The venom is stored in large glands called alveoli before being conveyed by a duct to the base of channeled or tubular fangs through which it's ejected. Venom contains more than 20 different compounds, which are mostly proteins and polypeptides . The complex mixture of proteins, enzymes, and various other substances has toxic and lethal properties. Venom serves to immobilize prey. Enzymes in venom play an important role in
13585-416: The hooded snakes ( Parasuta ), bandy-bandies ( Vermicella ), etc. Viper venom ( Russell's viper , saw-scaled vipers , bushmasters , and rattlesnakes ) acts more on the vascular system, bringing about coagulation of the blood and clotting of the pulmonary arteries; its action on the nervous system is not great, no individual group of nerve-cells appears to be picked out, and the effect upon respiration
13728-706: The hopes of a vaccine against snake venom being developed, and has survived over 160 bites from different species as of January 2016. The World Health Organization estimates that 80% of the world's population depends on traditional medicine for their primary health-care needs. Methods of traditional treatments of snakebites, although of questionable efficacy and perhaps even harmful, are nonetheless relevant. Plants used to treat snakebites in Trinidad and Tobago are made into tinctures with alcohol or olive oil and kept in rum flasks called snake bottles, which contain several different plants and/or insects. The plants used include
13871-446: The hotter parts of the Continent; whilst the small meadow viper ( Vipera ursinii ), which hardly ever bites unless roughly handled, does not seem to be possessed of a very virulent venom, and although very common in some parts of Austria and Hungary , is not known to have ever caused a serious accident. Biologists had long known that some snakes had rear fangs, 'inferior' venom injection mechanisms that might immobilize prey; although
14014-511: The huge venom diversity seen today. The original toxicoferan venom was a very simple set of proteins that were assembled in a pair of glands. Subsequently, this set of proteins evolved independently in the various lineages of toxicoferans, including Serpentes , Anguimorpha , and Iguania . Several snake lineages have since lost the ability to produce venom, often due to a change in diet or a change in predatory tactics. In addition to this, venom strength and composition has changed due to changes in
14157-521: The intolerant emperor of Delhi. They took advantage of the Aravalli hills and caused heavy damage to the Mughal armies that were trying to occupy Rajasthan. After Aurangzeb's death Bahadur Shah I tried to subjugate Rajasthan like his ancestors but his plan backfired when the three Rajput Rajas of Amber , Udaipur , and Jodhpur made a joint resistance to the Mughals . The Rajputs first expelled
14300-540: The last two decades. Snake venom toxicity is assessed by a toxicological test called the median lethal dose , lethal dose 50% (abbreviated as LD 50 ), which determines the concentration of a toxin required to kill half the members of a tested population. The potency of wild snake venom varies considerably because of assorted influences such as biophysical environment , physiological status, ecological variables , genetic variation (either adaptive or incidental), and other molecular and ecological evolutionary factors. This
14443-403: The list of animals refractory to viper venom. Some populations of California ground squirrel ( Otospermophilus beecheyi ) are at least partially immune to rattlesnake venom as adults. The acquisition of human immunity against snake venom is ancient (from around 60 CE, Psylli tribe). Research into development of vaccines that will lead to immunity is ongoing. Bill Haast , owner and director of
14586-547: The ministry of forestry is situated in Jodhpur and continuously works on desert flora and their conservation. Ranthambore National Park is 7 km from Sawai Madhopur Railway Station. It is known worldwide for its tiger population and is considered by both wilderness lovers and photographers as one of the best places in India to spot tigers. At one point, due to poaching and negligence, tigers became extinct at Sariska, but five tigers have been relocated there. Prominent among
14729-435: The molecules. Scientists performed experiments on the opossums and found that multiple trials showed replacement to silent substitutions in the von Willebrand factor ( vWf ) gene that encodes for a venom-targeted hemostatic blood protein. These substitutions are thought to weaken the connection between vWf and a toxic snake venom ligand (botrocetin), which changes the net charge and hydrophobicity. These results are significant to
14872-510: The mouth (suction cups from snake bite kits can be used, but suctioning seldom provides any measurable benefit). Serotherapy using antivenom is a common current treatment and has been described back in 1913. Both adaptive immunity and serotherapy are specific to the type of snake; venom with identical physiological action do not cross-neutralize. Boulenger 1913 describes the following cases: A European in Australia who had become immune to
15015-568: The name Rajasthan appears in the 1829 publication Annals and Antiquities of Rajasthan or the Central and Western Rajpoot States of India , while the earliest known record of Rajputana as a name for the region is in George Thomas 's 1800 memoir Military Memories . John Keay , in his book India: A History , stated that Rajputana was coined by the British in 1829, John Briggs, translating Ferishta 's history of early Islamic India, used
15158-458: The other Rajput states, constitutes a glorious saga of Rajput valor and the spirit of self-sacrifice for cherished principles. Rana Pratap's methods of sporadic warfare were later elaborated further by Malik Ambar, the Deccani general, and by Shivaji". Rana Amar Singh I continued his ancestor's war against the Mughals under Jehangir , he repelled the Mughal armies at Dewar. Later an expedition
15301-642: The other hand, the latter consists of Civil and Sessions Judges. The District Judge has control over the Subordinate Judicial Service in Rajasthan. The politics of Rajasthan has mainly been dominated mainly by the Bharatiya Janata Party and the Indian National Congress . Chief Secretary Of Rajasthan is Usha Sharma and Director General of Police or DGP of Rajasthan is Umesh Mishra. Rajasthan
15444-525: The overlord of the subcontinent, was finally replaced by the British Empire in 1818. In the 19th century, the Rajput kingdoms were exhausted, they had been drained financially and in manpower after continuous wars and due to heavy tributes exacted by the Maratha Empire . To save their kingdoms from instability, rebellions and banditry the Rajput kings concluded treaties with the British in
15587-455: The park with several species of amphibians, reptiles, birds and mammals reported to have died as roadkill. The Ranthambore National Park located in Sawai Madhopur , one of the well known tiger reserves in the country, became a part of Project Tiger in 1973. Tal Chhapar Sanctuary is a very small sanctuary in Sujangarh , Churu District , 210 kilometres (130 mi) from Jaipur in
15730-766: The phrase " Rajpoot (Rajput) princes" rather than "Indian princes". Parts of what is now Rajasthan were partly part of the Vedic Civilisation and the Indus Valley civilisation . Kalibangan , in Hanumangarh district , was a major provincial capital of the Indus Valley Civilisation. Topsfield writes that the Rajputs first entered India from the north west in the first millennium A.D. They established kingdoms in western India in
15873-487: The pit viper (mongooses and hedgehogs) show the same type of relationship between snakes, which helps to support the hypothesis that venom has a very strong defensive role along with a trophic role. Which in turn supports the idea that predation on the snakes can be the arms race that produces snake venom evolution. Some of the various adaptations produced by this process include venom more toxic to specific prey in several lineages, proteins that pre-digest prey, as well as
16016-843: The present day Sahibi River as the Vedic Drishadwati River, which along with Saraswati River formed the borders of the Vedic state of Brahmavarta. Manu and Bhrigu narrated the Manusmriti to a congregation of seers in this area. The ashrams of Vedic seers Bhrigu and his son Chayvan Rishi, for whom Chyawanprash was formulated, were near Dhosi Hill , part of which lies in Dhosi village of Jhunjhunu district of Rajasthan and part of which lies in Mahendragarh district of Haryana . The Western Kshatrapas (405–35 BCE),
16159-414: The prey of certain snake species. For example, the venom of the marbled sea snake ( Aipysurus eydouxii ) became significantly less toxic after the diet of this species changed from fish to strictly fish eggs. The evolution of venom is thought to be responsible for the enormous expansion of snakes across the globe. The mechanism of evolution in most cases has been gene duplication in tissues unrelated to
16302-595: The progress of the Arabs beyond the confines of Sindh , their only conquest for nearly 300 years. The Ghurids had made an attempt to invade India through southern Rajasthan, however they were defeated in the Battle of Kasahrada on 1178 by a confederacy of Rajputs under Mularaja II of the Kingdom of Gujarat . Prithviraj Chauhan led a confederacy of Rajput clans and defeated the invading Ghruids under Muhammad Ghori in
16445-499: The rate of electricity access from 71% of the population in 2015). The renewable energy sector plays the most important role in the increase of generation capacities, with the main focus on solar energy . In 2020, Bhadla Solar Park was recognised as the largest cluster of photovoltaic power plants in a single region in the world, with the installed power exceeding the 2.2 gigawatt peak. Jaipur International Airport (JAI) in Jaipur,
16588-690: The region that is now known as Rajasthan. An archaeological excavation at the Balathal site in Udaipur district shows a settlement contemporary with the Harrapan civilisation dating back to 3000–1500 BCE. Stone Age tools dating from 5,000 to 200,000 years were found in Bundi and Bhilwara districts of the state. The Matsya kingdom of the Vedic civilisation of India is said to roughly corresponded to
16731-442: The resistance. Maharana Pratap took an oath to avenge the citizens of Chittor; he fought the Mughal empire till his death and liberated most of Mewar apart from Chittor itself. Maharana Pratap soon became the most celebrated warrior of Rajasthan and became famous all over India for his sporadic warfare and noble actions. According to Satish Chandra , "Rana Pratap's defiance of the mighty Mughal empire, almost alone and unaided by
16874-517: The second-largest producer of oilseeds . Rajasthan is also the biggest wool -producing state in India and the main opium producer and consumer. There are mainly two crop seasons. The water for irrigation comes from wells and tanks. The Indira Gandhi Canal irrigates northwestern Rajasthan. The main industries are mineral based, agriculture-based, and textile based. Rajasthan is the second-largest producer of polyester fibre in India. Several prominent chemical and engineering companies are located in
17017-405: The southeast. The northwest tract is sandy and unproductive with little water but improves gradually from desert land in the far west and northwest to comparatively fertile and habitable land towards the east. The south-eastern area, higher in elevation (100 to 350 m above sea level) and more fertile, has a very diversified topography. In the south lies the hilly tract of Mewar. In the southeast,
17160-534: The southeast; and Gujarat to the southwest. Its geographical location is 23°.3' to 30°.12' North latitude and 69°.30' to 78°.17' East longitude, with the Tropic of Cancer passing through its southernmost tip. Its major features include the ruins of the Indus Valley civilisation at Kalibangan and Balathal , the Dilwara Temples , a Jain pilgrimage site at Rajasthan's only hill station , Mount Abu , in
17303-401: The specific diets that affect the intraspecific evolution of venom. Venoms continue to evolve as specific toxins and are modified to target a specific prey, and toxins are found to vary according to diet in some species. Rapid venom evolution can also be explained by the arms race between venom-targeted molecules in resistant predators, such as the opossum , and the snake venom that targets
17446-404: The state. Jaipur , Jodhpur , and Kota have two municipal corporations each since October 2019, as their populations have exceeded 1 million. Major internet service provider (ISP) and telecom companies are present in Rajasthan including Vodafone Idea , BSNL , Airtel , Jio , Data Infosys Limited , RailTel Corporation of India , Software Technology Parks of India (STPI). Data Infosys
17589-559: The states of Ajmer and Alwar in Rajasthan, and defeated Akbar's forces twice, first at Agra and then at Delhi in 1556 at Battle of Delhi before acceding to the throne of Delhi and establishing the "Hindu Raj" in North India , albeit for a short duration, from Purana Qila in Delhi. Hem Chandra was killed in the battlefield at Second Battle of Panipat fighting against Mughals on 5 November 1556. During Akbar 's reign most of
17732-422: The states of the Rajputana Agency of the erstwhile British Empire in India were merged into the new Indian Union . Its capital and largest city is Jaipur . Other important cities are Jodhpur , Kota , Bikaner , Ajmer , Sarwar , Bharatpur and Udaipur . The economy of Rajasthan is the seventh-largest state economy in India with ₹ 10.20 lakh crore (US$ 120 billion) in gross domestic product and
17875-934: The tehsil level. The president of India appoints the chief justice of the High Court of Rajasthan judiciary on the advice of the Chief Justice of the Supreme Court of India as well as the governor of Rajasthan. In Rajasthan, the Subordinate Judicial Service is an essential component of the state's judiciary, and it is divided into two categories: the Rajasthan Civil Judicial Services and the Rajasthan Higher Judicial Service. The former includes Civil Judges (Junior Division)/Judicial Magistrates and Civil Judges (Senior Division)/Chief Judicial Magistrate. On
18018-505: The temporal region serving to press out the venom into the duct, this action is performed by those of the side of the body. Considerable variability in biting behavior is seen among snakes. When biting, viperid snakes often strike quickly, discharging venom as the fangs penetrate the skin, and then immediately release. Alternatively, as in the case of a feeding response, some viperids (e.g. Lachesis ) bite and hold. A proteroglyph or opisthoglyph may close its jaws and bite or chew firmly for
18161-632: The territories of Marwar up to Sindh-Cholistan in west and his northern boundary was just fifty kilometres from Delhi. After defeating Humayun, Sher Shah came towards Rajputana. He defeated Chiefs of Rathore army by trickery in Battle of Sammel and captured some territory of Marwar but it was recovered by Rathores in 1545. Hem Chandra Vikramaditya , the Hindu emperor, was born in the village of Machheri in Alwar District in 1501. He won 22 battles against Afghans, from Punjab to Bengal including
18304-563: The type of envenomation that has occurred. In the Americas, polyvalent antivenoms are available that are effective against the bites of most pit vipers. Crofab is the antivenom developed to treat the bite of North American pit vipers. These are not effective against coral snake envenomation, which requires a specific antivenom to their neurotoxic venom. The situation is even more complex in countries such as India, with its rich mix of vipers (Viperidae) and highly neurotoxic cobras and kraits of
18447-399: The venom discharged through the distal orifice. When the snake bites, the jaws close and the muscles surrounding the gland contract, causing venom to be ejected via the fangs. In the proteroglyphous elapids , the fangs are tubular, but are short and do not possess the mobility seen in vipers. Opisthoglyphous colubrids have enlarged, grooved teeth situated at the posterior extremity of
18590-470: The venom evolution because it's the first citation of rapid evolution in a venom-targeted molecule. This shows that an evolutionary arms race may be occurring in terms of defensive purposes. Alternative hypotheses suggest that venom evolution is due to trophic adaption, whereas these scientists believe, in this case, that selection would occur on traits that help with prey survival in terms of venom evolution instead of predation success. Several other predators of
18733-517: The venom of rattlesnake species. The king cobra, which does prey on cobras, is said to be immune to their venom. The hedgehog (Erinaceidae), the mongoose (Herpestidae), the honey badger ( Mellivora capensis ) and the opossum are known to be immune to a dose of snake venom. Recently, the honey badger and domestic pig were found to have convergently evolved amino-acid replacements in their nicotinic acetylcholine receptor, which are known to confer resistance to alpha-neurotoxins in hedgehogs. Whether
18876-525: The venom of the black-necked spitting cobra ( Naja nigricollis ), an elapid, consists mainly of cytotoxins , while that of the Mojave rattlesnake ( Crotalus scutulatus ), a viperid, is primarily neurotoxic. Both elapids and viperids may carry numerous other types of toxins. The beginning of a new neural impulse goes as follows: Myotoxins are small, basic peptides found in rattlesnake and lizard (e.g. Mexican beaded lizard ) venoms. This involves
19019-420: The venom of the deadly Australian tiger snake ( Notechis scutatus ), manipulating these snakes with impunity, and was under the impression that his immunity extended also to other species, when bitten by a lowland copperhead ( Austrelaps superbus ), an allied elapine, died the following day. In India , the serum prepared with the venom of monocled cobra Naja kaouthia has been found to be without effect on
19162-467: The venom of two species of kraits ( Bungarus ), Russell's viper ( Daboia russelli ), saw-scaled viper ( Echis carinatus ), and Pope's pit viper ( Trimeresurus popeiorum ). Russell's viper serum is without effect on colubrine venoms, or those of Echis and Trimeresurus . In Brazil , serum prepared with the venom of lanceheads ( Bothrops spp.) is without action on rattlesnake ( Crotalus spp.) venom. Antivenom snakebite treatment must be matched as
19305-462: The venom. Pre-existing salivary proteins are the likely ancestors of most venom toxin genes. Expression of the new protein in the venom gland followed duplication. Then proceeded natural selection for adaptive traits following the birth-and-death model, where duplication is followed by functional diversification, resulting in the creation of structurally related proteins that have slightly different functions. The study of venom evolution has been
19448-498: The vine called monkey ladder ( Bauhinia cumanensis or Bauhinia excisa , Fabaceae), which is pounded and put on the bite. Alternatively, a tincture is made with a piece of the vine and kept in a snake bottle. Other plants used include mat root ( Aristolochia rugosa ), cat's claw ( Pithecellobim unguis-cati ), tobacco ( Nicotiana tabacum ), snake bush ( Barleria lupulina ), obie seed ( Cola nitida ), and wild gri gri root ( Acrocomia aculeata ). Some snake bottles also contain
19591-507: The west, starting in the days of Junaid . Historian R. C. Majumdar says that this was openly acknowledged by the Arab writers. He further notes that historians of India have wondered at the slow progress of Muslim invaders in India, as compared with their rapid advance in other parts of the world. Now there seems little doubt that it was the power of the Pratihara army that effectively barred
19734-513: The western slopes of the Aravallis and emptying southwest into the great Rann of Kutch wetland in neighbouring Gujarat . This river is saline in the lower reaches and remains potable only up to Balotara in Barmer district . The Ghaggar River , which originates in Haryana , is an intermittent stream that disappears into the sands of the Thar Desert in the northern corner of the state and is seen as
19877-401: The wildlife sanctuaries are Mount Abu Sanctuary, Bhensrod Garh Sanctuary, Darrah Sanctuary , Jaisamand Sanctuary, Kumbhalgarh Wildlife Sanctuary , Jawahar Sagar Sanctuary, and Sita Mata Wildlife Sanctuary. The state is governed by a parliamentary system of representative democracy. The governor serves as the state's constitutional leader, whereas the chief minister assumes the role of both
20020-653: Was Mewar . Since the invasion of the Muslim Turks from the 13th century onwards, the Rajputs resisted the Muslim incursions into India, and preserved Hindu culture at their courts. The Rajputs put up resistance to the Islamic invasions with their warfare and chivalry for centuries. The Ranas of Mewar led other kingdoms in their resistance to outside rule. Rana Hammir Singh defeated the Tughlaq dynasty and recovered
20163-412: Was again sent under the leadership of Prince Khurram , which caused much damage to life and property of Mewar . Many temples were destroyed, several villages were put on fire and women and children were captured and tortured to make Amar Singh accept surrender. During Aurangzeb 's rule Rana Raj Singh I , Veer Durgadas Rathore and Patshah Akheraj Singh Rajpurohit were chief among those who defied
20306-472: Was not widely adopted until later due to the scarity of large-scale chromatography equipment. Methods incorporating chromatography generally begin with cryo-depleted plasma undergoing buffer exchange via either diafiltration or buffer exchange chromatography, to prepare the plasma for following ion exchange chromatography steps. After ion exchange, generally purification steps and buffer exchange occur. However, chromatographic methods began to be adopted in
20449-459: Was the first ISP to bring the internet to Rajasthan in April 1999 and OASIS was the first private mobile telephone company. Rajasthan's economy is primarily agricultural and pastoral . Wheat and barley are cultivated over large areas, as are pulses , sugarcane , and oilseeds . Cotton and tobacco are the state's cash crops. Rajasthan is among the largest producers of edible oils in India and
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