1X59 , 2LW7 , 4G84 , 4G85 , 4PHC , 4X5O
4-512: 3035 15115 ENSG00000170445 ENSMUSG00000001380 P12081 Q61035 NM_001289093 NM_001289094 NM_008214 NP_001276023 NP_002100 NP_032240 Histidyl-tRNA synthetase ( HARS ) also known as histidine-tRNA ligase , is an enzyme which in humans is encoded by the HARS gene . Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids . The protein encoded by this gene
8-399: Is a cytoplasmic enzyme which belongs to the class II family of aminoacyl tRNA synthetases . The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter . The gene product
12-407: Is a frequent target of autoantibodies in the human autoimmune disease polymyositis / dermatomyositis . HARS has been shown to interact with EEF1B2 and EEF1G . This article on a gene on human chromosome 5 is a stub . You can help Misplaced Pages by expanding it . Histidine-tRNA ligase In enzymology , a histidine-tRNA ligase ( EC 6.1.1.21 ) is an enzyme that catalyzes
16-467: The chemical reaction The 3 substrates of this enzyme are ATP , L-histidine , and tRNA(His) , whereas its 3 products are AMP , diphosphate , and L-histidyl-tRNA(His) . This enzyme participates in histidine metabolism and aminoacyl-trna biosynthesis . Histidine—tRNA ligase belongs to the family of ligase enzymes, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class
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