HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5 .
3-594: DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution, having diverged from DRB1 approximately 4 million years ago. DRB5 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB5. DRB5* is subdivided into two allele groups, DRB5*01 and DRB5*02. B5*01 encodes 14 alleles and 11 isoforms. B5*02 encoded 4 alleles that can generate 4 isoforms. Only 3 of these have been surveyed by serotyping. There are numerous null genes at this locus. DRB5*01 allele group DRB5*02 allele group DR51 serotype
6-528: Is positively associated with The following HLA- DRB5 alleles are associated with disease: DRB5*0101:DRB1*1501 Multiple sclerosis, leprosy HLA-DRB5 (DR51)is linked to the following HLA-DR serotypes and DRB1 allele groups. HLA-DR2 HLA-DR2 HLA-DR2 (DR2) of the HLA - DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of
9-530: The HLA-DRB1*15 and HLA-DRB1*16 allele groups. DR2 serotypes are associated with Goodpasture syndrome , systemic lupus erythematosus , multiple sclerosis , narcolepsy , tuberculoid leprosy ( multi-drug-resistant tuberculosis or leprosy), ulcerative colitis (Japanese), primary biliary cirrhosis and autoimmune hepatitis . DR2 is also found in all patients that test positive for anti-Asn-RNA-synthetase and chronic interstitial lung disease. DR2
#170829