The Human Protein Atlas (HPA) is a Swedish-based program started in 2003 with the aim to map all the human proteins in cells , tissues and organs using integration of various omics technologies, including antibody -based imaging, mass spectrometry -based proteomics , transcriptomics and systems biology . All the data in the knowledge resource is open access to allow scientists both in academia and industry to freely access the data for exploration of the human proteome . In June 2023, version 23 was launched where a new Interaction section was introduced containing human protein-protein interaction networks for more than 11,000 genes that will add new aspects in terms of protein function.
19-485: The resource now includes twelve separate sections with complementary information about all human proteins. All data has been updated on the approximately 5 million individual web pages. The Human Protein Atlas program has already contributed to several thousands of publications in the field of human biology and disease and was selected by the organization ELIXIR as a European core resource due to its fundamental importance for
38-441: A specific type of organism. For example, zoology is the study of animals, while botany is the study of plants. Other life sciences focus on aspects common to all or many life forms, such as anatomy and genetics . Some focus on the micro-scale (e.g. molecular biology , biochemistry ) other on larger scales (e.g. cytology , immunology , ethology , pharmacy, ecology). Another major branch of life sciences involves understanding
57-584: A wider life science community. The HPA consortium is funded by the Knut and Alice Wallenberg Foundation . The Human Protein Atlas consists of twelve sections: In addition to the twelve sections of HPA, exploring gene and protein expression, there are various features available at the HPA website to assist the research community, including integrated external resources, such as Metabolic Atlas, educational material and free downloadable data. The Human Protein Atlas program
76-805: Is also involved in an organisational capacity, for example for the CORBEL, FAIRplus, EOSC-Life, B1MG, GDI and BY-COVID projects. Each member state jointly contributes towards the funding of the ELIXIR Hub in proportion to their GDP. Some countries have allocated new funds to contribute towards their ELIXIR Node. The services and activities of the ELIXIR Nodes will continue to be funded by national agencies. Collectively, ELIXIR members will apply for additional external funding. In 2024, ELIXIR commences its fourth five-year scientific programme . Bioscience This list of life sciences comprises
95-408: Is an initiative that allows life science laboratories across Europe to share and store their research data as part of an organised network. Its goal is to bring together Europe's research organisations and data centres to help coordinate the collection, quality control and storage of large amounts of biological data produced by life science experiments. ELIXIR aims to ensure that biological data
114-550: Is integrated into a federated system easily accessible by the scientific community. ELIXIR's mission is to build a sustainable European infrastructure for biological information, supporting life science research and its translation to medicine and the environment, the bio-industries and society. The results from biological experiments produce vast amounts of results that are stored as data using computer software . European countries have invested heavily in research that produces, analyses and stores biological information. However,
133-651: Is put into validating the antibody reagents used for profiling of tissues and cells, and the HPA has implemented stringent antibody validation criteria as suggested by the International Working Group for Antibody Validation (IWGAV). The Human Protein Atlas program has participated in 9 EU research projects ENGAGE , PROSPECTS , BIO_NMD , AFFINOMICS , CAGEKID , EURATRANS , ITFoM , DIRECT and PRIMES. ELIXIR ELIXIR (the European life-sciences infrastructure for biological information)
152-491: Is the only Node that is not associated with a country. ELIXIR focuses efforts around five central areas of activity, referred to as Platforms . These cover Data, Tools, Compute, Interoperability and Training. Work in these areas is intended to improve access to open data resources and tools by improving connectivity, discoverability and access to computational power, as well as developing training for users and service providers to meet these aims. ELIXIR supports users addressing
171-433: The branches of science that involve the scientific study of life – such as microorganisms , plants, and animals including human beings . This science is one of the two major branches of natural science , the other being physical science , which is concerned with non-living matter. Biology is the overall natural science that studies life, with the other life sciences as its sub-disciplines. Some life sciences focus on
190-686: The ECA in the near future. Countries that have signed the ECA are allocated representation on the ELIXIR Board . The preparatory phase of ELIXIR was coordinated by Professor Dame Janet Thornton of EMBL-EBI . The Founding Director of ELIXIR, Dr Niklas Blomberg, took up his position in the new ELIXIR Hub in Cambridge in May 2013. He left ELIXIR in December 2023 and Prof Tim Hubbard has been appointed
209-489: The ELIXIR consortium are European countries, represented by their governments and ministries; the scientific community in each member country develops their national Node , which operates the services and resources that are part of ELIXIR. Each ELIXIR Node is itself a network of national life science organisations, coordinated by a lead institute. European Molecular Biology Laboratory is an intergovernmental organisation so it
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#1732773102624228-632: The Grand Challenges in life science research across diverse domains. ELIXIR supports a range of self-selected Communities , which focus on high-level topics such as ‘Human Data’ and ‘Plant Sciences’ to more specific and focused disciplines such as ‘Metabolomics’ and ‘Intrinsically Disordered Proteins’, as well as a community dedicated to the ‘Galaxy’ resource. These communities are in place to develop bioinformatic and data standards, services and training that are required to facilitate that community to reach their scientific goals. As of September 2023
247-554: The United States, South Korea, China, and India. Professor Mathias Uhlén is the director of the program. The research underpinning the start of the exploration of the whole human proteome in the Human Protein Atlas program was carried out in the late 1990s and early 2000s. A pilot study employing an affinity proteomics strategy using affinity-purified antibodies raised against recombinant human protein fragments
266-499: The collection, storage, archiving and integration of these large amounts of data presents a problem that cannot be tackled by one country alone. ELIXIR represents the joining of independent bioscience facilities to create an integrated network that addresses the complex problem of biological data storage and management. By providing a sustainable and distributed structure for handling data and data retrieval tools, ELIXIR hopes to secure Europe-wide investment in bioinformatics , providing
285-632: The following countries and EMBL-EBI have signed the ELIXIR Consortium Agreement (ECA) in order to become a member of ELIXIR: Belgium, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Israel, Italy, Luxembourg, the Netherlands, Norway, Portugal, Slovenia, Spain, Sweden, Switzerland, and the United Kingdom. Austria, Cyprus and Romania are Observer countries, working towards ratifying
304-835: The new Director as of March 2024. By the end of 2012 ELIXIR completed its five-year preparatory phase funded by the EU's Seventh Framework Programme as part of the European Strategy Forum on Research Infrastructures (ESFRI) process. In 2015 ELIXIR was awarded €19 Million HORIZON 2020 funding to run the EXCELERATE project, this was followed by the CONVERGE project in 2020. Both projects enabled ELIXIR to coordinate and extend national and international data resources. ELIXIR has also set up collaborations to apply for other large scale funding for other EU projects, in which it
323-657: The stability to conduct research in all areas of life science, both in academia and industry. ELIXIR is an inter-governmental organisation which brings together existing bioinformatics resources. It is coordinated by the ELIXIR Hub, based alongside the European Molecular Biology Laboratory's European Bioinformatics Institute ( EMBL -EBI) on the Wellcome Trust Genome Campus in Hinxton, Cambridge. The members of
342-662: Was carried out for a chromosome-wide protein profiling of chromosome 21. Other projects were also carried out to establish processes for parallel and automated affinity purification of mono-specific antibodies and their validation. Antibodies and antigens, produced in the Human Protein Atlas workflow, are used in research projects to study potential biomarkers in various diseases, such as breast cancer, prostate cancer, colon cancer, diabetes, autoimmune diseases, ovarian cancer and renal failure. Researchers involved with Human Protein Atlas projects, are sharing protocols and method details in an open-access group on protocols.io. A large effort
361-706: Was started in 2003 and funded by the non-profit organization Knut and Alice Wallenberg Foundation (KAW). The main site of the project is the Royal Institute of Technology (KTH), School of Engineering Sciences in Chemistry, Biotechnology and Health (Stockholm, Sweden). Additionally, the project involves research groups at Uppsala University, Karolinska Institutet, Chalmers University of Technology and Lund University, as well as several present and past international collaborations initiated with research groups in Europe,
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