4DOH
17-600: (Redirected from Il-20 ) IL-20 or IL 20 may refer to: Interleukin 20 , a protein in humans Illinois's 20th congressional district , an obsolete district Illinois Route 20 Ilyushin Il-20 (1948) , a prototype Soviet ground attack aircraft Ilyushin Il-20M , a military variant of the Soviet-era Il-18 turboprop aircraft [REDACTED] Topics referred to by
34-451: A broad range of functions and is involved in a variety of immune and non-immune processes in the body. For example, IL-20 is involved in the process of wound healing , proliferation of epithelial cells , prevention of apoptosis of epithelial cells , regulation of differentiation of keratinocytes during inflammation , the expansion of multipotential hematopoietic progenitor cells , and more. A specific receptor for this cytokine
51-508: Is a β-chain with a short intracellular domain . IL20RB, along with the IL-20 receptor, alpha subunit, form the heterodimeric type I interleukin-20 receptor, which binds the cytokines IL-19 , IL-20 and IL-24 . IL20RB also associates with IL-22 receptor, to form the heterodimeric type II interleukin-20 receptor, which also binds IL-20 and IL-24. After a cytokine binds both the IL20RB and
68-415: Is also associated with bladder cancer . On the other hand, IL-20 is known to prevent tissue damage as a result of chronic inflammation which may reduce the chance of developing cancer . So the role of IL-20 in cancer development is ambiguous and needs to be further explored. IL-20 is an angiogenesis factor and is highly expressed in artery plaques found in patients with atherosclerosis . IL-20
85-437: Is believed to be involved in both pro-inflammatory and anti-inflammatory responses. IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis , osteoclasts , found in bones, and epithelial cells of the intestine and trachea . IL20RB is also found in some immune cells. The subunit has been linked with multiple diseases, including gastrointestinal diseases and glaucoma. IL20RB
102-453: Is different from Wikidata All article disambiguation pages All disambiguation pages Interleukin 20 50604 58181 ENSG00000162891 ENSMUSG00000026416 Q9NYY1 Q9JKV9 NM_018724 NM_021380 NM_001311091 NP_061194 NP_001298020 NP_067355 Interleukin 20 (IL20) is a protein that is in humans encoded by the IL20 gene which
119-471: Is highly upregulated in psoriatic skin . Dysfunctional regulation of IL-20 could lead to uncontrollable wound healing in psoriasis , which could be a contributing factor to the pathogenesis of this disease . Because IL-20 is involved in the promotion of proliferation of epithelial cells it is also linked to the development of cancer . Receptors for IL-20 are very often expressed on tumorous cells of epithelial origin. High expression of IL-20
136-405: Is in the public domain . Interleukin 20 receptor, beta subunit 4DOH 53833 213208 ENSG00000174564 ENSMUSG00000044244 Q6UXL0 E9Q9A6 NM_144717 NM_001033543 NM_001037246 NP_653318 NP_001028715 Interleukin 20 receptor , beta subunit (IL20R2 or IL20RB) is a subunit of the interleukin-20 receptor and interleukin-22 receptor . It
153-493: Is involved in many stages of rheumatoid arthritis (RA) progression. IL-20 stimulates the secretion of chemokines MCP-1 and IL-8 in synovial fibroblasts , which attract neutrophils and T-cells . IL-20 is also an upstream regulator of TNF-α , IL-1 , and IL-6 , which are involved in the pathogenesis of RA . IL-20 is highly expressed in the synovial fluid of RA patients. Serum levels of IL-20 are not different from those of healthy controls, suggesting that IL-20
170-533: Is involved in the pathogenesis of RA only at local sites of inflammation . Receptors for IL-20 are highly expressed in the synovial membranes of RA patients. Due to the clear association of IL-20 with RA , anti-IL-20 antibody is now in a clinical trial for RA . Anti-IL-20 monoclonal antibodies have been researched as clinical candidates for the treatment or prevention of psoriasis , rheumatoid arthritis , atherosclerosis , osteoporosis , and stroke . The anti-IL-20 antibody has been shown to reduce
187-420: Is linked with atherosclerosis and gastrointestinal diseases , although its specific roles are unknown. IL20RB mRNA is expressed in retinal ganglion cells and optic nerves in rats. Mutations in the IL20RB gene are associated with glaucoma . The specific links between IL20RB and glaucoma are unknown, but IL20RB does not have a causative effect on the disease, instead contributing to an increased risk of
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#1732787436535204-585: Is located in close proximity to the IL-10 gene on the 1q32 chromosome . IL-20 is a part of an IL-20 subfamily which is a part of a larger IL-10 family . IL-20 subfamily also includes other cytokines , including IL-19 , IL-20, IL-22 , IL-24 , and IL-26 . Members of the cytokine IL-20 subfamily form an important link between the immune system and epithelial tissues due to the fact that receptors for these cytokines are highly expressed on epithelial cells and are almost exclusively produced by cells of
221-492: Is mainly produced by myeloid cells such as monocytes , granulocytes , and dendritic cells but can also be produced by keratinocytes and fibroblasts . The expression of IL-20 is stimulated by IL-1β , IL-17 , IL-22 , TNF , and LPS . The main cellular targets of IL-20 are keratinocytes , endothelial cells , and adipocytes . IL-20 has been shown to transduce its signal through signal transducer and activator of transcription 3 ( STAT3 ) in keratinocytes . IL-20 has
238-476: The immune system . IL-20 requires an IL-β-subunit receptor ( IL-20RB ) for signaling, which can form a functional heterodimeric receptor with either the α-subunit of the IL-20 receptor (IL-20RA) or the α1-subunit of the IL-22 receptor (IL-22RA1) . Both of these receptor variants allow efficient IL-20 signaling. Receptors for IL-20 are expressed in the skin , lungs , ovary , testes , and placenta . IL-20
255-515: The alpha subunit of the IL20 receptor, a signal is sent through the JAK-STAT signaling pathway. This signaling pathway leads STAT to act as a transcription factor, which can gene expression. IL20RB mRNA is present in some immune cells, including monocytes , natural killer cells , B-cells , T-cells , and some hematopoietic stem cells . It is known what role IL20RB plays in these cells. IL20RB
272-450: The same term This disambiguation page lists articles associated with the same title formed as a letter–number combination. If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=IL-20&oldid=1108838765 " Category : Letter–number combination disambiguation pages Hidden categories: Short description
289-568: The severity of RA in rats , mitigate bone destruction, and more. The anti-IL-20 antibody neutralizes not only IL-20 signaling but also decreases TNF-α , IL-1 , and IL-6 signaling in vivo. A human recombinant monoclonal antibody against IL-20 developed by Novo Nordisk Inc. now entered the IIb phase of a clinical trial . This article incorporates text from the United States National Library of Medicine , which
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