Ilafy is a town and commune ( Malagasy : kaominina ) in Madagascar . It belongs to the district of Ambatondrazaka , which is a part of Alaotra-Mangoro Region . The population of the commune was estimated to be approximately 13,000 in 2001 commune census .
102-454: Primary and junior level secondary education are available in town. The majority 96% of the population of the commune are farmers, while an additional 1% receives their livelihood from raising livestock. The most important crop is rice , while other important products are cassava , sweet potatoes and bambara groundnut . Industry and services provide employment for 0.5% and 1.5% of the population, respectively. Additionally fishing employs 1% of
204-416: A sustainable way. Many varieties of rice have been bred to improve crop quality and productivity. Biotechnology has created Green Revolution rice able to produce high yields when supplied with nitrogen fertiliser and managed intensively. Other products are rice able to express human proteins for medicinal use; flood-tolerant or deepwater rice ; and drought-tolerant and salt-tolerant varieties. Rice
306-501: A Tolerable Upper Intake Level (UL) for β-carotene. The European Food Safety Authority, acting for the European Union, also decided not to set a UL for β-carotene. Carotenoderma , also referred to as carotenemia, is a benign and reversible medical condition where an excess of dietary carotenoids results in orange discoloration of the outermost skin layer. It is associated with a high blood β-carotene value. This can occur after
408-403: A branched inflorescence which arises from the last internode on the stem. There can be up to 350 spikelets in a panicle, each containing male and female flower parts ( anthers and ovule ). A fertilised ovule develops into the edible grain or caryopsis . Rice is a cereal belonging to the family Poaceae . As a tropical crop, it can be grown during the two distinct seasons (dry and wet) of
510-714: A means of preventing and treating VAD. Doses were 50,000 to 100,000 IU ( International units ) for children aged 6 to 11 months and 100,000 to 200,000 IU for children aged 12 months to five years, the latter typically every four to six months. In addition to a 24% reduction in all-cause mortality, eye-related results were reported. Prevalence of Bitot's spots at follow-up were reduced by 58%, night blindness by 68%, xerophthalmia by 69%. RA regulates gene transcription by binding to nuclear receptors known as retinoic acid receptors (RARs; RARα, RARβ, RARγ) which are bound to DNA as heterodimers with retinoid "X" receptors (RXRs; RXRα, RXRβ, RXRγ). RARs and RXRs must dimerize before they can bind to
612-566: A month or two of consumption of β-carotene rich foods, such as carrots, carrot juice, tangerine juice, mangos, or in Africa, red palm oil. β-carotene dietary supplements can have the same effect. The discoloration extends to palms and soles of feet, but not to the white of the eye , which helps distinguish the condition from jaundice . Consumption of greater than 30 mg/day for a prolonged period has been confirmed as leading to carotenemia. For U.S. food and dietary supplement labeling purposes,
714-458: A pivotal role during development. Altering levels of endogenous RA signaling during early embryology, either too low or too high, leads to birth defects, including congenital vascular and cardiovascular defects. Of note, fetal alcohol spectrum disorder encompasses congenital anomalies, including craniofacial, auditory, and ocular defects, neurobehavioral anomalies and mental disabilities caused by maternal consumption of alcohol during pregnancy. It
816-411: A role in various religions and traditions, such as in weddings . The rice plant can grow to over 1 m (3 ft) tall; if in deep water, it can reach a length of 5 m (16 ft). A single plant may have several leafy stems or tillers . The upright stem is jointed with nodes along its length; a long slender leaf arises from each node. The self-fertile flowers are produced in a panicle ,
918-495: A self-regulating feedback loop. Vitamin A status involves eye health via two separate functions. Retinal is an essential factor in rod cells and cone cells in the retina responding to light exposure by sending nerve signals to the brain. An early sign of VAD is night blindness. Vitamin A in the form of retinoic acid is essential to normal epithelial cell functions. Severe VAD, common in infants and young children in southeast Asia causes xerophthalmia characterized by dryness of
1020-483: A short-acting gene transcription signal. This deactivation is mediated by a cytochrome P450 (CYP) enzyme system, specifically enzymes CYP26A1 , CYP26B1 and CYP26C1 . CYP26A1 is the predominant form in the human liver; all other human adult tissues contained higher levels of CYP26B1. CYP26C1 is expressed mainly during embryonic development. All three convert retinoic acid into 4-oxo-RA, 4-OH-RA and 18-OH-RA. Glucuronic acid forms water-soluble glucuronide conjugates with
1122-514: A single domestication event for O. sativa . Both indica and japonica forms of Asian rice sprang from a single domestication event in China from the wild rice Oryza rufipogon . Despite this evidence, it appears that indica rice arose when japonica arrived in India about 4,500 years ago and hybridised with another rice, whether an undomesticated proto- indica or wild O. nivara . Rice
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#17327803202991224-554: A vitamin A-deficient diet, while maintaining blood levels in the normal range. Only when the liver stores are nearly depleted will signs and symptoms of deficiency show. Retinol is reversibly converted to retinal, then irreversibly to retinoic acid, which activates hundreds of genes . VAD is common in developing countries, especially in Sub-Saharan Africa and Southeast Asia . Deficiency can occur at any age but
1326-440: A wide variety of pests including insects, nematodes, rodents such as rats, snails, and birds. Major rice insect pests include armyworms, rice bugs , black bugs , cutworms, field crickets, grasshoppers, leafhoppers, mealybugs, and planthoppers. High rates of nitrogen fertiliser application may worsen aphid outbreaks. Weather conditions can contribute to pest outbreaks: rice gall midge outbreaks are worsened by high rainfall in
1428-453: A β- ionone ring. The primary dietary form is retinol , which may have a fatty acid molecule attached, creating a retinyl ester , when stored in the liver. Retinol – the transport and storage form of vitamin A – is interconvertible with retinal, catalyzed to retinal by retinol dehydrogenases and back to retinol by retinaldehyde reductases. Retinal, (also known as retinaldehyde) can be irreversibly converted to all-trans -retinoic acid by
1530-436: Is rainfed like wheat or maize. Across Asia, unmilled rice or "paddy" (Indonesian and Malay padi ), was traditionally the product of smallholder agriculture, with manual harvesting . Larger farms make use of machines such as combine harvesters to reduce the input of labour. The grain is ready to harvest when the moisture content is 20–25%. Harvesting involves reaping , stacking the cut stalks, threshing to separate
1632-678: Is 69% water, 29% carbohydrates , 2% protein , and contains negligible fat (table). In a reference serving of 100 grams (3.5 oz), cooked white rice provides 130 calories of food energy , and contains moderate levels of manganese (18% DV), with no other micronutrients in significant content (all less than 10% of the Daily Value ). In 2018, the World Health Organization strongly recommended fortifying rice with iron , and conditionally recommended fortifying it with vitamin A and with folic acid . Golden rice
1734-627: Is a major food staple in Asia, Latin America, and some parts of Africa, feeding over half the world's population. However, a substantial part of the crop can be lost post-harvest through inefficient transportation, storage, and milling. A quarter of the crop in Nigeria is lost after harvest. Storage losses include damage by mould fungi if the rice is not dried sufficiently. In China, losses in modern metal silos were just 0.2%, compared to 7–13% when rice
1836-504: Is a variety produced through genetic engineering to synthesize beta-carotene , a precursor of vitamin A, in the endosperm of the rice grain. It is intended to be grown and eaten in parts of the world where Vitamin A deficiency is prevalent. Golden rice has been opposed by activists, such as in the Philippines . In 2016 more than 100 Nobel laureates encouraged the use of genetically modified organisms , such as golden rice, for
1938-404: Is absorbed from the digestive tract via passive diffusion . Unlike retinol, β-carotene is taken up by enterocytes by the membrane transporter protein scavenger receptor B1 (SCARB1), which is upregulated in times of vitamin A deficiency (VAD). Retinol is stored in lipid droplets in the liver . A high capacity for long-term storage of retinol means that well-nourished humans can go months on
2040-526: Is acutely toxic to humans because content has been reported in range of 2,215 to 10,400 μg/g wet weight. As noted, in humans, retinol circulates bound to RBP4. Carnivores maintain R-RBP4 within a tight range while also having retinyl esters in circulation. Bound retinol is delivered to cells while the esters are excreted in the urine. In general, carnivore species are poor converters of ionone-containing carotenoids, and pure carnivores such as felidae (cats) lack
2142-581: Is based on four principles: biodiversity, host plant resistance, landscape ecology, and hierarchies in a landscape—from biological to social. Farmers' pesticide applications are often unnecessary. Pesticides may actually induce resurgence of populations of rice pests such as the brown planthopper , both by destroying beneficial insects and by enhancing the pest's reproduction. The International Rice Research Institute (IRRI) demonstrated in 1993 that an 87.5% reduction in pesticide use can lead to an overall drop in pest numbers. Farmers in China, Indonesia and
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#17327803202992244-499: Is bound to RBP4. Strict carnivores manage vitamin A differently than omnivores and herbivores . Carnivores are more tolerant of high intakes of retinol because those species have the ability to excrete retinol and retinyl esters in urine. Carnivores also have the ability to store more in the liver, due to a higher ratio of liver HSCs to hepatocytes compared to omnivores and herbivores. For humans, liver content can range from 20 to 30 μg/gram wet weight. Notoriously, polar bear liver
2346-412: Is common, vitamin A supplementation public health programs initiated in the 1980s were shown to reduce the incidence of diarrhea and measles, and all-cause mortality. VAD also increases the risk of immune system over-reaction, leading to chronic inflammation in the intestinal system, stronger allergic reactions and autoimmune diseases. Lymphocytes and monocytes are types of white blood cells of
2448-639: Is for this reason that a deficiency in vitamin A will inhibit the reformation of rhodopsin, and will lead to one of the first symptoms, night blindness. VAD-caused night blindness is a reversible difficulty for the eyes to adjust to dim light. It is common in young children who have a diet inadequate in retinol and β-carotene. A process called dark adaptation typically causes an increase in photopigment amounts in response to low levels of illumination. This increases light sensitivity by up to 100,000 times compared to normal daylight conditions. Significant improvement in night vision takes place within ten minutes, but
2550-508: Is from Asia. The average world yield for rice was 4.7 metric tons per hectare (2.1 short tons per acre), in 2022. Yuan Longping of China's National Hybrid Rice Research and Development Center set a world record for rice yield in 1999 at 17.1 metric tons per hectare (7.6 short tons per acre) on a demonstration plot. This employed specially developed hybrid rice and the System of Rice Intensification (SRI), an innovation in rice farming. Rice
2652-429: Is in the normal range, gene expression for SCARB1 and BC01 are suppressed, creating a feedback loop that suppresses β-carotene absorption and conversion. Absorption suppression is not complete, as receptor 36 is not downregulated. The US National Academy of Medicine updated Dietary Reference Intakes (DRIs) in 2001 for vitamin A, which included Recommended Dietary Allowances (RDAs). For infants up to 12 months, there
2754-726: Is lower than expected from incidence of new cases only because childhood VAD significantly increases all-cause mortality. According to a 2017 Cochrane review, VAD, using serum retinol less than 0.70 μmol/L as a criterion, is a major public health problem affecting an estimated 190 million children under five years of age in low- and middle-income countries, primarily in Sub-Saharan Africa and Southeast Asia. In lieu of or in combination with food fortification programs, many countries have implemented public health programs in which children are periodically given very large oral doses of synthetic vitamin A, usually retinyl palmitate, as
2856-443: Is most common in pre-school age children and pregnant women, the latter due to a need to transfer retinol to the fetus. VAD is estimated to affect approximately one-third of children under the age of five around the world, resulting in hundreds of thousands of cases of blindness and deaths from childhood diseases because of immune system failure. Reversible night blindness is an early indicator of low vitamin A status. Plasma retinol
2958-446: Is no risk from consuming too much via commonly consumed foods. Only consumption of retinol-containing dietary supplements can result in acute or chronic toxicity. Acute toxicity occurs after a single or short-term doses of greater than 150,000 μg. Symptoms include blurred vision, nausea, vomiting, dizziness and headache within 8 to 24 hours. For infants ages 0–6 months given an oral dose to prevent development of VAD, bulging skull fontanel
3060-433: Is proposed that in the embryo there is competition between acetaldehyde, an ethanol metabolite, and retinaldehyde (retinal) for aldehyde dehydrogenase activity, resulting in a retinoic acid deficiency, and attributing the congenital birth defects to the loss of RA activated gene activation. In support of this theory, ethanol-induced developmental defects can be ameliorated by increasing the levels of retinol or retinal. As for
3162-812: Is sister to the bamboos, Bambusoideae , and the cereal subfamily Pooideae . The rice genus Oryza is one of eleven in the Oryzeae; it is sister to the Phyllorachideae . The edible rice species O. sativa and O. glaberrima are among some 300 species or subspecies in the genus. other grasses (inc. the C4 grasses , maize , sorghum ) Streptogyneae Ehrharteae Phyllorachideae Wild rices inc. Zizania other rice species and subspecies O. sativa (Asian rice) O. glaberrima (African rice) Bambusoideae (bamboos) Pooideae (grasses and cereals inc. wheat , barley ) Oryza sativa rice
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3264-694: Is stickier, and is used for sweet dishes, and in Italy for risotto ; and sticky short-grain rice is used in Japanese sushi as it keeps its shape when cooked. White rice when cooked contains 29% carbohydrate and 2% protein, with some manganese . Golden rice is a variety produced by genetic engineering to contain vitamin A . Production of rice is estimated to have caused over 1% of global greenhouse gas emissions in 2022. Predictions of how rice yields will be affected by climate change vary across geographies and socioeconomic contexts. In human culture, rice plays
3366-523: Is stopped. In 2001, for the purpose of determining ULs for adults, the US Institute of Medicine considered three primary adverse effects and settled on two: teratogenicity , i.e., causing birth defects, and liver abnormalities. Reduced bone mineral density was considered, but dismissed because the human evidence was contradictory. During pregnancy, especially during the first trimester, consumption of retinol in amounts exceeding 4,500 μg/day increased
3468-438: Is subjected to a steaming process before it is milled. This makes the grain harder, and moves some of the grain's vitamins and minerals into the white part of the rice so these are retained after milling. Rice does not contain gluten , so is suitable for people on a gluten-free diet . Rice is a good source of protein and a staple food in many parts of the world, but it is not a complete protein as it does not contain all of
3570-468: Is taken up by the membrane transporter protein scavenger receptor class B, type 1 (SCARB1). Absorbed β-carotene is converted to retinal and then retinol. The first step of the conversion process consists of one molecule of β-carotene cleaved by the enzyme β-carotene-15, 15'-monooxygenase, which in humans and other mammalian species is encoded by the BCM01 gene, into two molecules of retinal. When plasma retinol
3672-454: Is the enzyme beta-carotene 15,15'-dioxygenase (formerly known as beta- carotene 15,15'-monooxygenase) coded for by the BCMO1 gene, responsible for symmetrically cleaving β-carotene into retinal. Absorbed β-carotene is either incorporated as such into chylomicrons or first converted to retinal and then retinol, bound to RBP2. After a meal, roughly two-thirds of the chylomicrons are taken up by
3774-640: Is the staple food of over half of the world's population , particularly in Asia and Africa . Rice is the seed of the grass species Oryza sativa (Asian rice)—or, much less commonly, Oryza glaberrima (African rice). Asian rice was domesticated in China some 13,500 to 8,200 years ago; African rice was domesticated in Africa about 3,000 years ago. Rice has become commonplace in many cultures worldwide; in 2021, 787 million tons were produced, placing it fourth after sugarcane , maize , and wheat . Only some 8% of rice
3876-410: Is the appearance of Bitot's spots, which are clumps of keratin debris that build up inside the conjunctiva. If untreated, xerophthalmia can lead to dry eye syndrome, corneal ulceration and ultimately to blindness as a result of cornea and retina damage. Although xerophthalmia is an eye-related issue, prevention (and reversal) are functions of retinoic acid having been synthesized from retinal rather than
3978-406: Is to flood the field to a depth of 5 cm (2 in), then to let the water level drop to 15 cm (6 in) below surface level, as measured by looking into a perforated field water tube sunk into the soil, and then repeating the cycle. Deepwater rice varieties tolerate flooding to a depth of over 50 centimetres for at least a month. Upland rice is grown without flooding, in hilly or mountainous regions; it
4080-509: Is traded internationally. China, India, and Indonesia are the largest consumers of rice. A substantial amount of the rice produced in developing nations is lost after harvest through factors such as poor transport and storage. Rice yields can be reduced by pests including insects , rodents , and birds , as well as by weeds , and by diseases such as rice blast . Traditional rice polycultures such as rice-duck farming , and modern integrated pest management seek to control damage from pests in
4182-414: Is used as a biomarker to confirm VAD. Breast milk retinol can indicate a deficiency in nursing mothers. Neither of these measures indicates the status of liver reserves. The European Union and various countries have set recommendations for dietary intake, and upper limits for safe intake. Vitamin A toxicity also referred to as hypervitaminosis A , occurs when there is too much vitamin A accumulating in
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4284-471: Is used as a model organism in biology. Dry rice grain is milled to remove the outer layers; depending on how much is removed, products range from brown rice to rice with germ and white rice. Some is parboiled to make it easy to cook. Rice contains no gluten ; it provides protein but not all the essential amino acids needed for good health. Rice of different types is eaten around the world. Long-grain rice tends to stay intact on cooking; medium-grain rice
4386-440: The essential amino acids in sufficient amounts for good health. World trade figures are much smaller than those for production, as less than 8% of rice produced is traded internationally. China, an exporter of rice in the early 2000s, had become the world's largest importer of rice by 2013. Developing countries are the main players in the world rice trade; by 2012, India was the largest exporter of rice, with Thailand and Vietnam
4488-407: The immune system , and healthy vision. For aiding vision specifically, it combines with the protein opsin to form rhodopsin , the light-absorbing molecule necessary for both low-light ( scotopic vision) and color vision . Vitamin A occurs as two principal forms in foods: A) retinoids, found in animal-sourced foods , either as retinol or bound to a fatty acid to become a retinyl ester, and B)
4590-475: The immune system . Lymphocytes include natural killer cells , which function in innate immunity , T cells for adaptive cellular immunity and B cells for antibody -driven adaptive humoral immunity . Monocytes differentiate into macrophages and dendritic cells . Some lymphocytes migrate to the thymus where they differentiate into several types of T cells, in some instances referred to as "killer" or "helper" T cells and further differentiate after leaving
4692-413: The innate immune response and maintains homeostasis of epithelial tissues and mucosa through its metabolite, retinoic acid (RA). As part of the innate immune system, toll-like receptors in skin cells respond to pathogens and cell damage by inducing a pro-inflammatory immune response which includes increased RA production. The epithelium of the skin encounters bacteria, fungi and viruses. Keratinocytes of
4794-432: The lumen of the small intestine to release free retinol. Retinol enters enterocytes by passive diffusion . Absorption efficiency is in the range of 70 to 90%. Humans are at risk for acute or chronic vitamin A toxicity because there are no mechanisms to suppress absorption or excrete the excess in urine. Within the cell, retinol is there bound to retinol binding protein 2 (RBP2). It is then enzymatically re-esterified by
4896-588: The 11- cis -retinal to rhodopsin cycle. Throughout southeast Asia, estimates are that more than half of children under the age of six years have subclinical VAD and night blindness, with progression to xerophthalmia being the leading cause of preventable childhood blindness. Estimates are that each year there are 350,000 cases of childhood blindness due to VAD. The causes are VAD during pregnancy, followed by low transfer of vitamin A during lactation and infant/child diets low in vitamin A or β-carotene. The prevalence of pre-school age children who are blind due to VAD
4998-478: The 21st century as people in Asia and elsewhere ate less grain and more meat. An exception is Sub-Saharan Africa, where both per capita consumption of rice and population are increasing. Rice is a commonly-eaten food around the world. The varieties of rice are typically classified as short-, medium-, and long-grained. Oryza sativa indica varieties are usually long-grained; Oryza sativa japonica varieties are usually short- or medium-grained. Short-grain rice, with
5100-704: The Americas by the Spanish. In British North America by the time of the start of the American War of Independence , rice had become the fourth most valuable export commodity behind only tobacco, wheat, and fish. In 2021, world production of rice was 787 million tonnes , led by China and India with a combined 52% of the total. This placed rice fourth in the list of crops by production, after sugarcane , maize , and wheat . Other major producers were Bangladesh , Indonesia and Vietnam . 90% of world production
5202-470: The DNA. Expression of more than 500 genes is responsive to retinoic acid. RAR-RXR heterodimers recognize retinoic acid response elements on DNA. Upon binding retinoic acid, the receptors undergo a conformational change that causes co-repressors to dissociate from the receptors. Coactivators can then bind to the receptor complex, which may help to loosen the chromatin structure from the histones or may interact with
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#17327803202995304-466: The Philippines have traditionally managed weeds and pests by the polycultural practice of raising ducks and sometimes fish in their rice paddies. These produce valuable additional crops, eat small pest animals, manure the rice, and in the case of ducks also control weeds. Rice plants produce their own chemical defences to protect themselves from pest attacks. Some synthetic chemicals, such as
5406-669: The US setting an adult upper limit of 3,000 μg/day, some US companies sell vitamin A (as retinyl palmitate) as a dietary supplement with amounts of 7,500 μg/day. Some countries require or recommend fortification of foods. As of January 2022, 37 countries, mostly in Sub-Saharan Africa, require food fortification of cooking oil , rice, wheat flour or maize (corn) flour with vitamin A, usually as retinyl palmitate or retinyl acetate. Examples include Pakistan, oil, 11.7 mg/kg and Nigeria, oil, 6 mg/kg; wheat and maize flour, 2 mg/kg. An additional 12 countries, mostly in southeast Asia, have
5508-496: The absorption of provitamin-A carotenoids is only half as much as previously thought. As a result, in 2001 the US Institute of Medicine recommended a new unit, the retinol activity equivalent (RAE). Each μg RAE corresponds to 1 μg retinol, 2 μg of β-carotene in oil, 12 μg of "dietary" β-carotene, or 24 μg of the three other dietary provitamin-A carotenoids. Animal models have shown that at the enterocyte cell wall, β-carotene
5610-551: The accepted equivalences have changed over time. For many years, a system of equivalencies in which an international unit (IU) was equal to 0.3 μg of retinol (~1 nmol), 0.6 μg of β-carotene, or 1.2 μg of other provitamin-A carotenoids was used. This relationship was alternatively expressed by the retinol equivalent (RE): one RE corresponded to 1 μg retinol, to 2 μg β-carotene dissolved in oil, to 6 μg β-carotene in foods, and to 12 μg of either α-carotene , γ-carotene , or β- cryptoxanthin in food. Newer research has shown that
5712-416: The action of lecithin retinol acyltransferase and incorporated into chylomicrons that are secreted into the lymphatic system . Unlike retinol, β-carotene is taken up by enterocytes by the membrane transporter protein scavenger receptor B1 (SCARB1). The protein is upregulated in times of VAD . If vitamin A status is in the normal range, SCARB1 is downregulated, reducing absorption. Also downregulated
5814-948: The action of retinal dehydrogenase Retinoic acid is actively transported into the cell nucleus by CRABp2 where it regulates thousands of genes by binding directly to gene targets via retinoic acid receptors . In addition to retinol, retinal and retinoic acid, there are plant-, fungi- or bacteria-sourced carotenoids which can be metabolized to retinol, and are thus vitamin A vitamers. There are also what are referred to as 2nd, 3rd and 4th generation retinoids which are not considered vitamin A vitamers because they cannot be converted to retinol, retinal or all-trans -retinoic acid. Some are prescription drugs, oral or topical, for various indications. Examples are etretinate , acitretin , adapalene , bexarotene , tazarotene and trifarotene . Retinyl esters from animal-sourced foods (or synthesized for dietary supplements for humans and domesticated animals) are acted upon by retinyl ester hydrolases in
5916-993: The amount in a serving is expressed as a percent of Daily Value (%DV). For vitamin A labeling purposes, 100% of the Daily Value was set at 5,000 IU, but it was revised to 900 μg RAE on 27 May 2016. A table of the old and new adult daily values is provided at Reference Daily Intake . μg RAE (2001) per 100 g Vitamin A is found in many foods. Vitamin A in food exists either as preformed retinol – an active form of vitamin A – found in animal liver, dairy and egg products, and some fortified foods, or as provitamin A carotenoids, which are plant pigments digested into vitamin A after consuming carotenoid-rich plant foods, typically in red, orange, or yellow colors. Carotenoid pigments may be masked by chlorophylls in dark green leaf vegetables, such as spinach. The relatively low bioavailability of plant-food carotenoids results partly from binding to proteins – chopping, homogenizing or cooking disrupts
6018-465: The benefits these could bring. In 2022, greenhouse gas emissions from rice cultivation were estimated at 5.7 billion tonnes CO2eq, representing 1.2% of total emissions. Within the agriculture sector, rice produces almost half the greenhouse gas emissions from croplands , some 30% of agricultural methane emissions , and 11% of agricultural nitrous oxide emissions. Methane is released from rice fields subject to long-term flooding, as this inhibits
6120-444: The body. It comes from consumption of preformed vitamin A but not of carotenoids, as conversion of the latter to retinol is suppressed by the presence of adequate retinol. There are historical reports of acute hypervitaminosis from Arctic explorers consuming bearded seal or polar bear liver, both very rich sources of stored retinol, and there are also case reports of acute hypervitaminosis from consuming fish liver, but otherwise there
6222-493: The body. Symptoms may include nervous system effects, liver abnormalities, fatigue , muscle weakness, bone and skin changes, and others. The adverse effects of both acute and chronic toxicity are reversed after consumption of high dose supplements is stopped. Vitamin A is a fat-soluble vitamin , a category that also includes vitamins D , E and K . The vitamin encompasses several chemically related naturally occurring compounds or metabolites, i.e., vitamers , that all contain
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#17327803202996324-447: The carotenoids α-carotene ( alpha -carotene), β-carotene, γ-carotene ( gamma -carotene), and the xanthophyll beta-cryptoxanthin (all of which contain β- ionone rings) that function as provitamin A in herbivore and omnivore animals which possess the enzymes that cleave and convert provitamin carotenoids to retinol. Some carnivore species lack this enzyme. The other carotenoids do not have retinoid activity. Dietary retinol
6426-399: The cleaving enzyme entirely. They must have retinol or retinyl esters in their diet. Herbivores consume ionone-containing carotenoids and convert those to retinal. Some species, including cattle and horses, have measurable amounts of β-carotene circulating in the blood, and stored in body fat , creating yellow fat cells . Most species have white fat and no β-carotene in circulation. In
6528-688: The clinical evidence, an uncertainty factor of 5 was used, and with rounding, the UL was set at 3,000 μg/day. Despite a US UL set at 3,000 μg, it is possible to buy over-the-counter dietary supplement products which are 7,500 μg (25,000 IU), with a label caution statement "Not intended for long term use unless under medical supervision." For children, ULs were extrapolated from the adult value, adjusted for relative body weight. For infants, several case studies reported adverse effects that include bulging fontanels, increased intracranial pressure, loss of appetite, hyperirritability and skin peeling after chronic ingestion of
6630-454: The conjunctival epithelium and cornea. Untreated, xerophthalmia progresses to corneal ulceration and blindness. The role of vitamin A in the visual cycle is specifically related to the retinal compound. Retinol is converted by the enzyme RPE65 within the retinal pigment epithelium into 11- cis -retinal. Within the eye, 11- cis -retinal is bound to the protein opsin to form rhodopsin in rod cells and iodopsin in cone cells. As light enters
6732-511: The crop would be lost under these conditions. In the Po Valley in Italy, the arborio and carnaroli risotto rice varieties have suffered poor harvests through drought in the 21st century. The Ente Nazionale Risi [ it ] is developing drought-resistant varieties; its nuovo prometeo variety has deep roots that enable it to tolerate drought, but is not suitable for risotto. Rice yield can be reduced by weed growth, and
6834-431: The cycle by binding to opsin to reform rhodopsin in the retina. In addition, some of the all-trans -retinal may be converted to all-trans -retinol form and then transported with an interphotoreceptor retinol-binding protein to the retinal pigmented epithelial cells. Further esterification into all-trans -retinyl esters allow for storage of all-trans -retinol within the pigment epithelial cells to be reused when needed. It
6936-431: The epidermal layer of the skin produce and secrete antimicrobial peptides (AMPs). Production of AMPs resistin and cathelicidin , are promoted by RA. As some carotenoids can be converted into vitamin A, attempts have been made to determine how much of them in the diet is equivalent to a particular amount of retinol, so that comparisons can be made of the benefit of different foods. The situation can be confusing because
7038-425: The exception of Spanish Bomba, is usually sticky when cooked, and is suitable for puddings. Thai Jasmine rice is aromatic, and unusually for a long-grain rice has some stickiness, with a soft texture. Indian Basmati rice is very long-grained and aromatic. Italian Arborio rice , used for risotto , is of medium length, oval, and quite sticky. Japanese sushi rice is a sticky short-grain variety. Cooked white rice
7140-435: The eye, the 11- cis -retinal is isomerized to the all-trans form. The all-trans -retinal dissociates from the opsin in a series of steps called photo-bleaching. This isomerization induces a nervous signal along the optic nerve to the visual center of the brain. After separating from opsin, the all-trans -retinal is recycled and converted back to the 11- cis -retinal form by a series of enzymatic reactions, which then completes
7242-425: The field where they will grow, or seedlings can be grown in a seedbed and transplanted into the field. Direct seeding needs some 60 to 80 kg of grain per hectare, while transplanting needs less, around 40 kg per hectare, but requires far more labour. Most rice in Asia is transplanted by hand. Mechanical transplanting takes less time but requires a carefully-prepared field and seedlings raised on mats or in trays to fit
7344-511: The grain, and cleaning by winnowing or screening . The rice grain is dried as soon as possible to bring the moisture content down to a level that is safe from mould fungi. Traditional drying relies on the heat of the sun, with the grain spread out on mats or on pavements. The edible rice species are members of the BOP clade within the grass family, the Poaceae . The rice subfamily, Oryzoideae ,
7446-582: The great diversity and continuous evolution of pests. Resistance genes are being sought from wild species of rice, and genetic engineering techniques are being applied. Vitamin A Vitamin A is a fat-soluble vitamin that is an essential nutrient . The term "vitamin A" encompasses a group of chemically related organic compounds that includes retinol , retinyl esters , and several provitamin (precursor) carotenoids , most notably β-carotene ( beta - carotene ). Vitamin A has multiple functions: growth during embryo development, maintaining
7548-575: The herbicide 2,4-D , cause the plant to increase the production of certain defensive chemicals and thereby increase the plant's resistance to some types of pests. Conversely, other chemicals, such as the insecticide imidacloprid , appear to induce changes in the gene expression of the rice that make the plant more susceptible to certain pests. Plant breeders have created rice cultivars incorporating resistance to various insect pests . Conventional plant breeding of resistant varieties has been limited by challenges such as rearing insect pests for testing, and
7650-489: The inner wall of the small intestine. The net effect is a down-regulation of immune activity, seen as tolerance of food allergens , and tolerance of resident bacteria and other organisms in the microbiome of the large intestine. In a vitamin A deficient state, innate immunity is compromised and pro-inflammatory Th1 cells predominate. Deficiencies in vitamin A have been linked to an increased susceptibility to skin infection and inflammation. Vitamin A appears to modulate
7752-410: The later years of the 20th century decreased rice yield by between 10% and 20% across 200 farms in seven Asian countries. This may have been caused by increased night-time respiration. IRRI has predicted that Asian rice yields will fall by some 20% per 1°C rise in global mean temperature. Further, rice is unable to yield grain if the flowers experience a temperature of 35 °C or more for over one hour, so
7854-474: The lipid-rich chylomicrons, bind retinol to retinol-binding protein 4 (RBP4), and transfer the retinol-RBP4 to HSCs for storage in lipid droplets as retinyl esters. Mobilization reverses the process: retinyl ester hydrolase releases free retinol which is transferred to hepatocytes, bound to RBP4, and put into blood circulation. Other than either after a meal or when consumption of large amounts exceeds liver storage capacity, more than 95% of retinol in circulation
7956-453: The liver and peripheral tissues of humans, retinol is reversibly converted to retinal by the action of alcohol dehydrogenases, which are also responsible for the conversion of ethanol to acetaldehyde . Retinal is irreversibly oxidized to retinoic acid (RA) by the action of aldehyde dehydrogenases. RA regulates the activation or deactivation of genes. The oxidative degradation of RA is induced by RA – its presence triggers its removal, making for
8058-443: The liver with the remainder delivered to peripheral tissues. Peripheral tissues also can convert chylomicron β-carotene to retinol. The capacity to store retinol in the liver means that well-nourished humans can go months on a vitamin A deficient diet without manifesting signs and symptoms of deficiency. Two liver cell types are responsible for storage and release: hepatocytes and hepatic stellate cells (HSCs). Hepatocytes take up
8160-417: The machine. Rice does not thrive if continuously submerged. Rice can be grown in different environments, depending upon water availability. The usual arrangement is for lowland fields to be surrounded by bunds and flooded to a depth of a few centimetres until around a week before harvest time; this requires a large amount of water. The "alternate wetting and drying" technique uses less water. One form of this
8262-538: The order of 6,000 or more μg/day. Given the small database, an uncertainty factor of 10 divided into the "Lowest-Observed-Adverse-Effect Level" (LOAEL) led to a UL of 600 μg/day. No adverse effects other than carotenemia have been reported for consumption of β-carotene rich foods. Supplementation with β-carotene does not cause hypervitaminosis A. Two large clinical trials (ATBC and CARET) were conducted in tobacco smokers to see if years of β-carotene supplementation at 20 or 30 mg/day in oil-filled capsules would reduce
8364-428: The other largest exporters. As of 2016, the countries that consumed the most rice were China (29% of total), India, and Indonesia. By 2020, Bangladesh had taken third place from Indonesia. On an annual average from 2020-23, China consumed 154 million tonnes of rice, India consumed 109 million tonnes, and Bangladesh and Indonesia consumed about 36 million tonnes each. Across the world, rice consumption per capita fell in
8466-483: The oxidized metabolites, which are then excreted in urine and feces. Other than for vision, the metabolic functions of vitamin A are mediated by all-trans -retinoic acid (RA) . The formation of RA from retinal is irreversible. To prevent accumulation of RA it is oxidized and eliminated fairly quickly, i.e., has a short half-life. Three cytochromes catalyze the oxidation of retinoic acid. The genes for Cyp26A1, Cyp26B1 and Cyp26C1 are induced by high levels of RA, providing
8568-506: The plant proteins, increasing provitamin A carotenoid bioavailability. Vegetarian and vegan diets can provide sufficient vitamin A in the form of provitamin A carotenoids if the diet contains carrots, carrot juice, sweet potatoes, green leafy vegetables such as spinach and kale, and other carotenoid-rich foods. In the U.S., the average daily intake of β-carotene is in the range 2–7 mg. Some manufactured foods and dietary supplements are sources of vitamin A or β-carotene. Despite
8670-421: The population. Ilafy is of historical and cultural significance, widely considered one of the twelve sacred hills of Imerina . 17°53′S 48°25′E / 17.883°S 48.417°E / -17.883; 48.417 This Alaotra-Mangoro location article is a stub . You can help Misplaced Pages by expanding it . Rice Rice is a cereal grain and in its domesticated form
8772-471: The process can take up to two hours to reach maximal effect. People expecting to work in a dark environment wore red-tinted goggles or were in a red light environment to not reverse the adaptation because red light does not deplete rhodopsin versus what occurs with yellow or green light. Xerophthalmia, caused by a severe VAD, is described by pathologic dryness of the conjunctival epithelium and cornea. The conjunctiva becomes dry, thick, and wrinkled. Indicative
8874-466: The risk of birth defects, but not below that amount, thus setting a "No-Observed Adverse-Effect Level" (NOAEL). Given the quality of the clinical trial evidence, the NOAEL was divided by an uncertainty factor of 1.5 to set the UL for women of reproductive age at 3,000 μg/day of preformed vitamin A. For all other adults, liver abnormalities were detected at intakes above 14,000 μg/day. Given the weak quality of
8976-446: The risk of lung cancer. These trials were implemented because observational studies had reported a lower incidence of lung cancer in tobacco smokers who had diets higher in β-carotene. Unexpectedly, high-dose β-carotene or retinol supplementation resulted in a higher incidence of lung cancer and of total mortality due to cardiac mortality. Taking this and other evidence into consideration, the U.S. Institute of Medicine decided not to set
9078-437: The risks of too much RA during embryogenesis, the prescription drugs tretinoin ( all-trans -retinoic acid) and isotretinoin (13-cis-retinoic acid), used orally or topically for acne treatment, are labeled with block-box warnings for pregnant women or women who may become pregnant, as they are known human teratogens. VAD has been linked to compromised resistance to infectious diseases. In countries where early childhood VAD
9180-892: The same as in the United States. For women and men of ages 15 and older, the PRIs are set respectively at 650 and 750 μg RE/day. PRI for pregnancy is 700 μg RE/day, for lactation 1300/day. For children of ages 1–14 years, the PRIs increase with age from 250 to 600 μg RE/day. These PRIs are similar to the US RDAs. The EFSA reviewed the same safety question as the United States, and set ULs at 800 for ages 1–3, 1100 for ages 4–6, 1500 for ages 7–10, 2000 for ages 11–14, 2600 for ages 15–17 and 3000 μg/day for ages 18 and older for preformed vitamin A, i.e., not including dietary contributions from carotenoids. Vitamin A toxicity ( hypervitaminosis A ) occurs when too much vitamin A accumulates in
9282-1011: The soil from absorbing atmospheric oxygen, resulting in anaerobic fermentation of organic matter in the soil. Emissions can be limited by planting new varieties, not flooding continuously, and removing straw. It is possible to cut methane emissions in rice cultivation by improved water management, combining dry seeding and one drawdown, or executing a sequence of wetting and drying . This results in emission reductions of up to 90% compared to full flooding and even increased yields. Predictions of climate change's effects on rice cultivation vary. Global rice yield has been projected to decrease by around 3.2% with each 1°C increase in global average temperature while another study predicts global rice cultivation will increase initially, plateauing at about 3°C warming (2091–2100 relative to 1850–1900). The impacts of climate change on rice cultivation vary across geographic location and socioeconomic context. For example, rising temperatures and decreasing solar radiation during
9384-423: The thymus. Each subtype has functions driven by the types of cytokines secreted and organs to which the cells preferentially migrate, also described as trafficking or homing. Retinoic acid (RA) triggers receptors in bone marrow, resulting in generation of new white blood cells. RA regulates proliferation and differentiation of white blood cells, the directed movement of T cells to the intestinal system , and to
9486-464: The transcriptional machinery. This response upregulates or downregulates the expression of target genes, including the genes that encode for the receptors themselves. To deactivate retinoic acid receptor signaling, three cytochromes (Cyp26A1, Cyp26B1 Cyp26C1) catalyze the oxidation of RA. The genes for these proteins are induced by high concentrations of RA, thus providing a regulatory feedback mechanism. In vertebrates and invertebrate chordates, RA has
9588-543: The up- and down-regulation of lymphocyte function. If RA is adequate, T helper cell subtype Th1 is suppressed and subtypes Th2, Th17 and iTreg (for regulatory) are induced. Dendritic cells located in intestinal tissue have enzymes that convert retinal to all-trans -retinoic acid, to be taken up by retinoic acid receptors on lymphocytes. The process triggers gene expression that leads to T cell types Th2, Th17 and iTreg moving to and taking up residence in mesenteric lymph nodes and Peyer's patches , respectively outside and on
9690-648: The voyage to the rest of the Pacific. It reached Austroasiatic and Kra-Dai -speakers in Mainland Southeast Asia and southern China by 5000 years ago. Rice spread around the rest of the world through cultivation, migration and trade, eventually to the Americas as part of the Columbian exchange after 1492. The now less common Oryza glaberrima (African rice) was independently domesticated in Africa around 3,000 years ago, and introduced to
9792-785: The wet season, while thrips outbreaks are associated with drought. Rice blast , caused by the fungus Magnaporthe grisea , is the most serious disease of growing rice. It and bacterial leaf streak (caused by Xanthomonas oryzae pv. oryzae ) are perennially the two worst rice diseases worldwide; they are both among the ten most important diseases of all crop plants. Other major rice diseases include sheath blight (caused by Rhizoctonia solani ), false smut ( Ustilaginoidea virens ), and bacterial panicle blight ( Burkholderia glumae ). Viral diseases include rice bunchy stunt, rice dwarf, rice tungro , and rice yellow mottle. Crop protection scientists are developing sustainable techniques for managing rice pests. Sustainable pest management
9894-539: The year provided that sufficient water is made available. It is normally an annual, but in the tropics it can survive as a perennial , producing a ratoon crop. Like all crops, rice depends for its growth on both biotic and abiotic environmental factors. The principal biotic factors are crop variety, pests , and plant diseases . Abiotic factors include the soil type, whether lowland or upland, amount of rain or irrigation water, temperature, day length , and intensity of sunlight. Rice grains can be planted directly into
9996-474: Was evident after 24 hours, usually resolved by 72 hours. Chronic toxicity may occur with long-term consumption of vitamin A at doses of 25,000–33,000 IU/day for several months. Excessive consumption of alcohol can lead to chronic toxicity at lower intakes. Symptoms may include nervous system effects, liver abnormalities, fatigue , muscle weakness, bone and skin changes and others. The adverse effects of both acute and chronic toxicity are reversed after consumption
10098-469: Was first domesticated in China 9,000 years ago, by people of Neolithic cultures in the Upper and Lower Yangtze , associated with Hmong-Mien -speakers and pre-Austronesians , respectively. The functional allele for nonshattering , the critical indicator of domestication in grains, as well as five other single-nucleotide polymorphisms , is identical in both indica and japonica . This implies
10200-574: Was introduced early into Sino-Tibetan cultures in northern China by around 6000 to 5600 years ago, and to the Korean peninsula and Japan by around 5500 to 3200 years ago. It was also carried into Taiwan by the Dapenkeng culture by 5500 to 4000 years ago, before spreading southwards via the Austronesian migrations to Island Southeast Asia , Madagascar , and Guam , but did not survive
10302-505: Was not sufficient information to establish an RDA, so Adequate Intake (AI) is shown instead. As for safety, tolerable upper intake levels (ULs) were also established. For ULs, carotenoids are not added when calculating total vitamin A intake for safety assessments. The European Food Safety Authority (EFSA) refers to the collective set of information as Dietary Reference Values, with Population Reference Intake (PRI) instead of RDA, and Average Requirement instead of EAR. AI and UL are defined
10404-439: Was stored by rural households. The dry grain is milled to remove the outer layers, namely the husk and bran . These can be removed in a single step, in two steps, or as in commercial milling in a multi-step process of cleaning, dehusking, separation, polishing, grading, and weighing. Brown rice only has the inedible husk removed. Further milling removes bran and the germ to create successively whiter products. Parboiled rice
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