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137-630: The Illinois Lottery began operations on July 1, 1974, when lotteries in the United States were confined to areas of the Northeast and Midwest . The drawings are supervised by an independent auditor who certifies the winning results. Illinois was the only single jurisdictional state lottery to have their drawings televised nationwide (which were broadcast throughout the United States and much of Canada via WGN-TV 's national superstation feed WGN America [now NewsNation ]). The 9 p.m. newscast

274-581: A Chicago Tribune investigation found that the Illinois Lottery simply suspended many of its most expensive games before awarding its largest prizes. While many lotteries across the United States do not award all its largest, the Tribune investigation found that Illinois's rate of awarding top prizes was significantly lower. In one example, a game called The Good Life was distributed with tickets at $ 30 each, with two top prizes of $ 46 million, but

411-568: A clinically isolated syndrome (CIS) over a number of days with 45% having motor or sensory problems, 20% having optic neuritis, and 10% having symptoms related to brainstem dysfunction, while the remaining 25% have more than one of the aforementioned difficulties. With optic neuritis as the most common presenting symptom, people with MS notice sub-acute loss of vision, often associated with pain worsening on eye movement, and reduced color vision. Early diagnosis of MS-associated optic neuritis helps timely initiation of targeted treatments. However, it

548-618: A demyelinating disease , MS disrupts the nervous system's ability to transmit signals , resulting in a range of signs and symptoms , including physical, mental , and sometimes psychiatric problems. Symptoms include double vision , vision loss, eye pain, muscle weakness, and loss of sensation or coordination. MS takes several forms, with new symptoms either occurring in isolated attacks (relapsing forms) or building up over time (progressive forms). In relapsing forms of MS symptoms may disappear completely between attacks, although some permanent neurological problems often remain, especially as

685-538: A lumbar puncture can provide evidence of chronic inflammation in the central nervous system. The cerebrospinal fluid is tested for oligoclonal bands of IgG on electrophoresis , which are inflammation markers found in 75–85% of people with MS. Several diseases present similarly to MS. Medical professionals use a patient's specific presentation, history, and exam findings to make an individualized differential . Red flags are findings that suggest an alternate diagnosis, although they do not rule out MS. Red flags include

822-468: A "quick picked" number from 1 through 25 for each play. Matching the Extra Shot number increases the payout received. Players matching the Extra Shot and either 5, 4, 3, or 2 of the 6 numbers of the regular field receive a payout that is 25 times the payout without the Extra Shot. When matching the Extra Shot and 5 regular field numbers this is a variable amount that averages $ 50,000. When matching 4 it

959-437: A 30% chance of developing MS, 5% for a nonidentical twin, 2.5% for a sibling, and an even lower chance for a half sibling. If both parents are affected, the risk in their children is 10 times that of the general population. MS is also more common in some ethnic groups than others. Specific genes linked with MS include differences in the human leukocyte antigen (HLA) system—a group of genes on chromosome 6 that serves as

1096-440: A Beitel Criterion drawing machine debuted. Wednesday drawings were reintroduced on August 15, 1990. On January 15, 1998, the 6/54 matrix was scaled down to 6/48, featuring an all-cash jackpot that began at $ 1 million (previously, the jackpot was annuitized , with no cash option). The matrix changed again to 6/52 on April 14, 1999, and added a fourth prize, $ 3, for matching three numbers; the jackpot again became annuitized, but with

1233-549: A Mega Millions member, began selling tickets for both games on January 31, 2010. In 2012, the price of a Powerball play was raised to $ 2($ 3 with the "PowerPlay" option). Powerball tickets are sold in the same jurisdictions as Mega Millions. Powerball sales in Illinois were suspended on June 28, 2017, due to the state's budget dispute. Powerball sales resumed on July 7, 2017, after the Illinois House came to an agreement on

1370-478: A Saturday-only game, with six plus an "alternate" of 40 numbered balls being drawn. On May 19, 1984, it became a 6/44 game. On December 1, 1985, advance play was introduced. On January 15, 1986, Wednesday drawings were added; the game was played twice weekly until April 15, 1987. Beginning with the May 7, 1988 drawing, the matrix in which the six numbers could be drawn increased from 44 to 54. On April 7, 1990, new balls and

1507-603: A cash option. On April 1, 2021, the matrix is changed from 6/52 to 6/50 and the base wager was raised to $ 2 to support the entry for the Main draw and 2 additional draws (Lotto Million 1 and Lotto Million 2, both have a $ 1,000,000 cash prize). The odds of winning a jackpot in the game's current version are 1 in 15,890,700 for a single set of drawn numbers. In November 2012, Illinois introduced an add-on to Lotto, called Lotto Extra Shot. While regular Lotto plays are $ 2 per game, Lotto Extra Shot plays are $ 3. A Lotto Extra Shot purchase adds

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1644-409: A chance to obtain more winning number combinations. The option can be added for a cost equivalent to the player's original base wager(for example, if a Pick 3 wager is 50¢, it costs an additional 50¢ to add the "Fireball" option); The fireball number is drawn from 10 balls numbered 0 through 9 for each game during each day and night pick 3 and pick 4 drawing. Players can use the fireball number to replace

1781-442: A demyelinating process such as MS is bilateral internuclear ophthalmoplegia, where the patient experiences double vision when attempting to move their gaze to the right & left. Some 60% or more of MS patients find their symptoms, particularly including fatigue, are affected by changes in body temperature. The main measure of disability and severity is the expanded disability status scale (EDSS), with other measures such as

1918-513: A diagnosis of MS. As similarly described before, B-cells can also produce cytokines that induce an inflammatory immune response via activation of autoreactive T-cells. As such, higher levels of these autoreactive B-cells is associated with increased number of lesions & neurodegeneration as well as worse disability. Another cell population that is becoming increasingly implicated in MS are microglia . These cells are resident to & keep watch over

2055-420: A frequently updated set of guidelines used to establish an MS diagnosis. There is no cure for MS. Current treatments aim to mitigate inflammation and resulting symptoms from acute flares and prevent further attacks with disease-modifying medications. Physical therapy and occupational therapy , along with patient-centered symptom management, can help with people's ability to function. The long-term outcome

2192-725: A governor. Massachusetts and New Hampshire also shared a governor for some time. The beginnings of the American Revolutionary War would be in the Northeast, specifically in Massachusetts. The Battles of Lexington and Concord in northeast of Boston would be the first military engagements between the Revolutionaries and the British. Many of the major battles of the revolution would be fought in

2329-507: A gradual worsening over time without periods of recovery (10–15% of cases). A combination of these two patterns may also occur or people may start in a relapsing and remitting course that then becomes progressive later on. Relapses are usually unpredictable, occurring without warning. Exacerbations rarely occur more frequently than twice per year. Some relapses, however, are preceded by common triggers and they occur more frequently during spring and summer. Similarly, viral infections such as

2466-540: A new state budget. Beginning on April 22, 1987, the Illinois Lottery offered a second jackpot game called "Lotto 7". The game was drawn on Wednesday nights. Jackpots were paid in annuities, never offering a cash option. "Lotto 7" was discontinued on May 4, 1988. Players chose 7 numbers from 1 to 39. The "Lotto 7" Game replaced the Wednesday "Lotto" Draw. "My 3" began on September 9, 2012, with drawings held daily at 10:30 a.m. and 6:30 p.m. CT . The game, which

2603-485: A number drawn by the lottery to make new combinations. A fireball prize is awarded to players who match the numbers in any given fireball combination. A bonus prize will be awarded if the player matches the base game numbers and any of the resulting fireball combinations to where the Fireball number can replace a lottery drawn number that is identical to the Fireball number drawn. In the current version of Lucky Day Lotto,

2740-534: A parimutuel jackpot that starts at $ 2,000,000 and rolls by $ 150,000 until it is won. Players matching 5 of 6 numbers win a variable amount that averages $ 2,000, matching 4 of 6 win a variable amount that averages $ 50, matching 3 of 6 numbers win $ 5, and matching 2 of 6 win $ 1. Lotto drawings take place on Monday, Thursday, and Saturday. Lotto now has three drawings: the Jackpot drawing, Lotto Million 1, and Lotto Million 2. Historically, Lotto began on February 19, 1983, as

2877-793: A patient younger than 15 or older than 60, less than 24 hours of symptoms, involvement of multiple cranial nerves , involvement of organs outside of the nervous system , and atypical lab and exam findings. In an emergency setting, it is important to rule out a stroke or bleeding in the brain. Intractable vomiting, severe optic neuritis, or bilateral optic neuritis raises suspicion for neuromyelitis optica spectrum disorder (NMOSD). Infectious diseases that may look similar to multiple sclerosis include HIV, Lyme disease , and syphilis . Autoimmune diseases include neurosarcoidosis , lupus , Guillain-Barré syndrome , acute disseminated encephalomyelitis , and Behçet's disease . Psychiatric conditions such as anxiety or conversion disorder may also present in

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3014-539: A person's own immune system. As briefly detailed in the causes section of this article, MS is currently thought to stem from a failure of the body's immune system to kill off autoreactive T-cells & B-cells. Currently, the T-cell subpopulations that are thought to drive the development of MS are autoreactive CD8+ T-cells, CD4+ helper T-cells, and T H 17 cells. These autoreactive T-cells produce substances called cytokines that induce an inflammatory immune response in

3151-533: A player pays $ 1 and picks 5 numbers from a field of 1 to 45(or gets 5 randomly assigned numbers as a "quick pick"). Players matching all 5 numbers split a parimutuel jackpot that starts at $ 100,000. Players matching 4 of 5 numbers win $ 200, players matching 3 of 5 numbers win $ 15, and players matching 2 of 5 numbers win $ 1. Lucky Day Lotto drawings take place twice a day, seven days a week. For an additional $ 1 per game, players can add an EZMatch option. With EZMatch, five additional numbers are randomly assigned. If any of

3288-748: A relatively high risk and that live closer to the equator such as Sardinians , inland Sicilians , Palestinians , and Parsi . MS symptoms may increase if body temperature is dysregulated. Fatigue is particularly affected. Smoking may be an independent risk factor for MS. Stress may also be a risk factor, although the evidence to support this is weak. Association with occupational exposures and toxins —mainly organic solvents —has been evaluated, but no clear conclusions have been reached. Vaccinations were studied as causal factors; most studies, though, show no association. Several other possible risk factors, such as diet and hormone intake, have been evaluated, but evidence on their relation with

3425-469: A role in MS onset, although EBV alone may be insufficient to cause it. The nuclear antigen of EBV , which is the most consistent marker of EBV infection across all strains, has been identified as a direct source of autoreactivity in the human body. These antigens appear more likely to promote autoimmunity vitamin D-deficient persons. The exact nature of this relationship is poorly understood. MS

3562-502: A single-drawing game that was held on Monday through Saturday evenings. On March 20, 1983, the lottery began to offer Sunday drawings of Pick 3. Ten years later on December 20, 1993, it expanded to 14 draws weekly with the addition of midday drawings. Pick 3 draws three sets of balls numbered 0 through 9. Prices, options, and payouts vary. Pick 4, similar to Pick 3, began on February 16, 1982, with drawings held on Tuesday and Friday evenings. On August 27, 1984, drawings expanded to six nights

3699-428: A small proportion of those infected later develop MS. A study of more than 10 million US military members compared 801 people who developed MS to 1,566 matched controls who did not. The study found a 32-fold increased risk of MS development following EBV infection. It did not find an increased risk after infection with other viruses, including the similar cytomegalovirus . These findings strongly suggest that EBV plays

3836-493: A week with the addition of Monday, Wednesday, Thursday and Saturday draws. Sunday drawings were added on March 9, 1985. Concurrent with the expansion of Pick 3 to daily drawings, on December 20, 1993, Pick 4 expanded to 14 draws weekly with the addition of midday games. The game draws four sets of ten balls numbered 0 through 9. Prices, options and payouts vary. On September 1, 2013, the Illinois Lottery introduced an optional feature to Pick 3 and Pick 4, called "Fireball", to provide

3973-400: A week. In 2012, Little Lotto was renamed Lucky Day Lotto. On July 14, 2014, Lucky Day Lotto was changed again, to 5/45, with 4/5, 3/5, and 2/5 rewards being doubled while maintaining the same jackpot theology. In the current version of Lotto, a player pays $ 2 and picks 6 numbers from a field of 1 to 50 (or gets 6 randomly assigned numbers as a "quick pick"). Players matching all 6 numbers split

4110-525: A year for life prize was paid on a financial annuity over 20 years or the player was given a $ 1.2 million cash value for such annuity). The game was drawn 4 times a day every day (at 10:30 AM, 12:40 PM, 6:30 PM and at 9:22 PM central time). Northeast United States The Northeastern United States (also referred to as the Northeast , the East Coast , or the American Northeast )

4247-806: Is one of the four census regions defined by the United States Census Bureau . Located on the Atlantic coast of North America , the region borders Canada to its north, the Southern United States to its south, the Midwestern United States to its west, and the Atlantic Ocean to its east. The Northeast is one of the four regions defined by the U.S. Census Bureau for the collection and analysis of statistics. The Census Bureau defines

Illinois State Lottery - Misplaced Pages Continue

4384-671: Is $ 40 million. Players pick 5 numbers from 1 to 70 for the primary numbers and 1 number from 1 to 25 for the mega ball. Each set of numbers costs $ 2 for the base game, $ 3 with the megaplier add on, where players can win up to $ 5 million without hitting the jackpot. Initially, Mega Millions drawings were to be held at the WGN-TV studios; however, to entice the Georgia Lottery to switch from Powerball, The Big Game′s drawing machines were moved to Atlanta before its first drawing. Mega Millions tickets are currently sold in 44 states plus

4521-414: Is a known risk factor for developing MS. Inversely, those who live in areas of relatively higher sun exposure and subsequently increased UVB radiation have a decreased risk of developing MS. As of 2019, the north–south gradient of incidence is still present and is increasing. On the other hand, MS is more common in regions with northern European populations, so the geographic variation may simply reflect

4658-423: Is a variable amount that averages $ 1,250. When matching 3 regular field numbers the prize is $ 125, and when matching 2 it is $ 25. There is also a payout for matching the Extra Shot and 1 or no regular field numbers – $ 10 or $ 5, respectively. Matching the Extra Shot when also matching all 6 regular field numbers does not increase the jackpot payout. Multiple scratch games in varying amounts and themes are offered by

4795-480: Is an autoimmune disease with a combination of genetic and environmental causes underlying it. Both T-cells and B-cells are involved, although T-cells are often considered to be the driving force of the disease. The causes of the disease are not fully understood. The Epstein-Barr Virus (EBV) has been shown to be directly present in the brain of most cases of MS and the virus is transcriptionally active in infected cells. EBV nuclear antigens are believed to be involved in

4932-477: Is crucial to adhere to established diagnostic criteria when treating optic neuritis due to the broad range of alternative causes, such as neuromyelitis optica spectrum disorder (NMOSD), and other autoimmune or infectious conditions. The course of symptoms occurs in two main patterns initially: either as episodes of sudden worsening that last a few days to months (called relapses , exacerbations, bouts, attacks, or flare-ups) followed by improvement (85% of cases) or as

5069-536: Is difficult to predict; better outcomes are more often seen in women, those who develop the disease early in life, those with a relapsing course, and those who initially experienced few attacks. MS is the most common immune-mediated disorder affecting the central nervous system (CNS). Nearly one million people in the United States had MS in 2022, and in 2020, about 2.8 million people were affected globally, with rates varying widely in different regions and among different populations. The disease usually begins between

5206-439: Is more advanced, walking difficulties lead to higher risk of falling. Difficulties thinking and emotional problems such as depression or unstable mood are also common. The primary deficit in cognitive function that people with MS experience is slowed information-processing speed, with memory also commonly affected, and executive function less commonly. Intelligence, language, and semantic memory are usually preserved, and

5343-405: Is not considered a hereditary disease , but several genetic variations have been shown to increase its risk. Some of these genes appear to have higher expression levels in microglial cells than expected by chance. The probability of developing MS is higher in relatives of an affected person, with a greater risk among those more closely related. An identical twin of an affected individual has

5480-448: Is provided in the pathophysiology section of this article as well as the standalone article on the pathophysiology of MS . Early evidence suggested the association between several viruses with human demyelinating encephalomyelitis , and the occurrence of demyelination in animals caused by some viral infections. One such virus, Epstein-Barr virus (EBV), can cause infectious mononucleosis and infects about 95% of adults, though only

5617-511: Is responsible for the immune system's central tolerance, where autoreactive T-cells are killed without being released into circulation. A similar mechanism kills autoreactive B-cells in the bone marrow. Some autoreactive T-cells & B-cells may escape these defense mechanisms, which is where peripheral immune tolerance defenses take action by preventing them from causing disease. However, these additional lines of defense can still fail. Further detail on immune dysregulation's contribution to MS risk

Illinois State Lottery - Misplaced Pages Continue

5754-471: Is the most commonly used method of diagnosis with the Schumacher and Poser criteria being of mostly historical significance. The McDonald criteria states that patients with multiple sclerosis should have lesions which are disseminated in time (DIT) and disseminated in space (DIS), i.e. lesions which have appeared in different areas in the brain and at different times. Below is an abbreviated outline of

5891-417: Is typically diagnosed based on the presenting signs and symptoms, in combination with supporting medical imaging and laboratory testing. It can be difficult to confirm, especially early on, since the signs and symptoms may be similar to those of other medical problems. The McDonald criteria , which focus on clinical, laboratory, and radiologic evidence of lesions at different times and in different areas,

6028-496: The 2020 U.S. census , the population of the region was 57,609,148, representing 17.38% of the nation's total population. With an average of 345.5 people per square mile, the Northeast is 2.5 times as densely populated as the second-most dense region, the South . Since the last century, the U.S. population has been shifting away from the Northeast and Midwest toward the South and West . The region's racial composition as of 2020

6165-666: The Atlantic coastal plain , which extends south to the southern tip of Florida . The coastal plain areas include Cape Cod in Massachusetts, Long Island in New York, and most of New Jersey , and are generally low and flat with sandy soil and marshy land. The highlands, including the Piedmont and the Appalachian Mountains, are heavily forested, ranging from rolling hills to summits greater than 6,000 feet (1,800 m), and pocked with many lakes. The highest peak in

6302-770: The Battle of Yorktown in Virginia. The idea of an independent United States of America, with the designs of its government would be created primarily in the Northeast in a series of declarations, constitutions, and documents. The Continental Congresses would meet in Philadelphia, which would produce the Declaration of Independence and the Articles of Confederation . Following the American Revolution,

6439-469: The CNS , a person with MS can have almost any neurological symptom or sign referable to it. Fatigue is one of the most common symptoms of MS. Roughly 65% of people with MS experience fatigue symptomatology, and of these, some 15–40% report fatigue as their most disabling MS symptom. Autonomic , visual, motor, and sensory problems are also among the most common symptoms. The specific symptoms depend on

6576-675: The District of Columbia and the U.S. Virgin Islands. In late October 2017, Mega Millions became $ 2 per play ($ 3 with the "Megaplier"). Mega Millions sales in Illinois were suspended on June 30, 2017, due to the state's budget dispute. Mega Millions sales resumed on July 7, 2017, after the Illinois House came to an agreement on a new state budget. On October 13, 2009, the Mega Millions consortium and MUSL reached an agreement to cross-sell Mega Millions and Powerball . Illinois, already

6713-564: The English colonial empire . The territory became the colonies of New York and New Jersey . New Jersey was originally split into East Jersey and West Jersey until the two were united as a royal colony in 1702. New England played a prominent role in early American education. Starting in the 17th century, the larger towns in New England opened grammar schools , the forerunner of the modern high school . The first public school in

6850-511: The Mid-Atlantic states of New Jersey, New York, and Pennsylvania. This definition has been essentially unchanged since 1880 and is widely used as a standard for data tabulation. The U.S. Census Bureau has acknowledged the obvious limitations of this definition and the potential merits of a proposal created after the 1950 census, that would include changing regional boundaries to include Delaware , Maryland , and Washington, D.C. with

6987-525: The capital of the newly formed United States would move around in the states of Pennsylvania , New Jersey , and New York . It was based in New York City from 1785 until 1790, when it was moved to Congress Hall in Philadelphia , where it remained for a decade, until 1800, when the construction of the new national capital of Washington, D.C. was completed. The Constitutional Convention

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7124-487: The common cold , influenza , or gastroenteritis increase their risk. Stress may also trigger an attack. Many events do not to affect rates of relapse requiring hospitalization including vaccination , breast feeding , physical trauma, and Uhthoff's phenomenon . Many people with MS who become pregnant experience lower symptoms During the first months after delivery, the risk increases. Overall, pregnancy does not seem to influence long-term disability. MS

7261-404: The equator (e.g. those who live in northern regions of the world), although exceptions exist. The cause of this geographical pattern is not clear, although exposure to ultraviolet B (UVB) radiation and vitamin D levels may be possible explanations. For example, those who live in northern regions of the world have less exposure to UVB radiation and subsequently lower levels of vitamin D, which

7398-494: The humid subtropical zone ( Cfa/Do ) begins at Martha's Vineyard and extreme SW Rhode Island and extends southwestward down the coastal plain to central and southern Maryland. The oceanic climate zone ( Cfb/Do ) only exists on Block Island , Nantucket , and the far coastal islands of Maine. It is the only area of the Northeast where all months average between 0 and 22 °C (32 and 72 °F). Cape Cod borders this zone and warm-summer humid continental ( Dfb/Dc ). As of

7535-466: The major histocompatibility complex (MHC). The contribution of HLA variants to MS susceptibility has been known since the 1980s, and it has also been implicated in the development of other autoimmune diseases, such as type 1 diabetes and systemic lupus erythematosus . The most consistent finding is the association between higher risk MS development and the MHC allele DR15 , which is present in 30% of

7672-458: The multiple sclerosis functional composite being increasingly used in research. EDSS is also correlated with falls in people with MS. While it is a popular measure, EDSS has been criticized for some of its limitations, such as overreliance on walking. MS may have a prodromal phase in the years leading up to its manifestation, characterized by psychiatric issues, cognitive impairment, and increased use of healthcare. 85% of cases begin as

7809-504: The 17th century. The cultural area, known as the " Northeastern Woodlands ", in addition to covering the entire Northeast U.S., also covered much of what is now Canada and others regions of what is now the eastern United States . Among the many tribes inhabiting this area were those that made up the Iroquois nations and the numerous Algonquian peoples . In the United States of the 21st century, 18 federally recognized tribes reside in

7946-519: The 1960s. New York state lost its claim to being the most populated state after it was surpassed by California in the 1970s. Some Northeastern cities, including New York City, have recovered from its decline in the mid-20th century. Many new information and service industries have risen in the northeast, which has led to a boom in the 21st century in some cities in the Northeast like Boston, New York, and Philadelphia. Some other cities like Hartford , Syracuse, and Buffalo still are declining though in

8083-595: The 2006 fiscal year. The first contribution to the Capital Projects Fund occurred in 2010. In 2012, the Lottery contributed $ 639,875,000 to the CSF; $ 65,200,000 to the Capital Projects Fund; and $ 3,421,368 in support of the four special-cause instant games initiated to date. The Illinois Lottery has contributed more than $ 18 billion to charitable causes from its inception through 2013. Beginning on July 1, 2015,

8220-443: The 2017 McDonald Criteria for diagnosis of MS. As of 2017 , no single test (including biopsy) can provide a definitive diagnosis. Magnetic resonance imaging (MRI) of the brain and spine may show areas of demyelination (lesions or plaques). Gadolinium can be administered intravenously as a contrast agent to highlight active plaques, and by elimination, demonstrate the existence of historical lesions not associated with symptoms at

8357-468: The 21st century, a large industrial decline in the Northeast resulted in a depopulation of many Northeastern cities, many of which had not yet recovered from it into the 21st century. This led to the rise of programs of urban renewal and demolition of large parts of Northeastern cities during the mid and late 20th century. There has also been a large population shift to the Sun Belt states starting in

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8494-471: The 21st century. Hurricane Sandy would impact much of the northeast in 2012, severely damaging much of the coast and causing flooding inland. The hurricane would directly impact New Jersey and caused large amounts of flooding in New York City. Although the first settlers of New England were motivated by religion, since the 21st century, New England had become one of the least religious parts of

8631-599: The American involvement in both World Wars, the Northeast would become a large base of war production, with the Brooklyn Naval Yard producing many navy ships. Many worker strikes would occur in the states, including the Homestead strike in 1892. Many of these cities would see a peak population and industrial output in the aftermath of World War II in the 1950s. Starting in the 1950s and continuing into

8768-595: The Appalachians partially protect these locations from the extreme cold coming from the west and the interior of North America. The basic climate of the Northeast can be divided into a colder and snowier interior, including western Maryland, most of Pennsylvania, most of North Jersey , Upstate New York , and most of New England, and a milder coastal plain region from Cape Cod and southern Rhode Island southward, including Long Island , Southern Connecticut , New York City , central and southern New Jersey , part of

8905-452: The CNS, leading to the development of the disease. More recently, however, the role of autoreactive B-cells has been elucidated. Evidence of their contribution to the development of MS is implicated through the presence of oligoclonal IgG bands (antibodies produced by B-cells) in the CSF of patients with MS. The presence of these oligoclonal bands has been used as supportive evidence in clinching

9042-671: The CNS, responding to pathogens by shifting between pro- & anti-inflammatory states. Microglia have been shown to be involved in the formation of MS lesions and have been shown to be involved in other diseases that primarily affect the CNS white matter. Although, because of their ability to switch between pro- & anti-inflammatory states, microglia have also been shown to be able to assist in remyelination & subsequent neuron repair. As such, microglia are thought to be participating in both acute & chronic MS lesions, with 40% of phagocytic cells in early active MS lesions being proinflammatory microglia. The name multiple sclerosis refers to

9179-484: The EZMatch numbers match any of the regular field numbers chosen by the player, there is an instant payout of an amount varying from $ 2 to $ 5,000. Historically, on June 1, 1988, Illinois created "Cash 5", which began as a 5/35 game that was drawn on Mondays, Wednesdays and Fridays. On May 15, 1989, the game's name was changed to "Little Lotto Cash 5", then "Little Lotto". New drawing balls were introduced on April 6, 1990;

9316-534: The English colonies was the Boston Latin School , founded in 1635. In 1636, the colonial legislature of Massachusetts founded Harvard College , the oldest institution of higher learning in the United States. In 1681, William Penn , who wanted to give Quakers a land of religious freedom, founded Pennsylvania and extended freedom of religion to all citizens. Penn strongly desired access to

9453-585: The Illinois General Assembly. When the Lottery began in 1974, proceeds went into the state's General Revenue Fund. In 1985, a law was enacted to earmark all Lottery proceeds to the CSF. A similar initiative was vetoed a year earlier by then-governor James R. Thompson , who said the bill earmarking Lottery proceeds to the CSF would give people the wrong impression that the Lottery would be a panacea for school funding. The Lottery's first contributions from special-cause instant games occurred in

9590-581: The Illinois State Lottery suspended payouts on jackpots of $ 25,000 or more due to a state budget impasse that would eventually stretch to the end of August 2017. In October 2015, this was extended to all winnings above $ 600. The stated reason was that there was no legal authority for the Illinois Lottery or Illinois's comptroller to issue checks. Despite this, the state continued to offer its lottery games for play. The move has drawn criticism from some lawmakers, including one who has described

9727-489: The Internet by lotteries in United States jurisdictions was legal. On March 25, 2012, Illinois became the first jurisdiction to allow internet lottery sales. Adults with an IP address within the state of Illinois can play the Lottery in this manner. The program was approved to run for 36 to 48 months on a trial basis, before being implemented permanently sometime afterwards. The June 4, 2024 Mega Millions jackpot of $ 552 million

9864-519: The Lottery's YouTube channel. Prior to this date, the selection of the winning numbers had been broadcast on WGN-TV for more than 25 years. Winners of a Mega Millions(on an Illinois Lottery ticket) or a Lotto jackpot must choose the cash option within 60 days of the drawing if the cash option is desired (a Powerball jackpot winner on an Illinois Lottery ticket has 60 days after claiming to make their choice). Purchasers must be at least 18 years of age to purchase an Illinois Lottery ticket. In December 2016,

10001-568: The Mid-Atlantic states, but ultimately decided that "the new system did not win enough overall acceptance among data users to warrant adoption as an official new set of general-purpose State groupings. The previous development of many series of statistics, arranged and issued over long periods of time on the basis of the existing State groupings, favored the retention of the summary units of the current regions and divisions." The U.S. Census Bureau confirmed in 1994 that it would continue to "review

10138-613: The Northeast United States as having a total area of 181,324 sq mi (469,630 km ), making it the smallest region of the United States by total area. Anthropologists recognize the "Northeastern Woodlands" as one of the cultural regions that existed in the Western Hemisphere at the time of European colonists in the 15th and later centuries. Most did not settle in North America until

10275-529: The Northeast and Midwest and would become prominent towards the mid-19th century, these groups advocated the shrinking or banning of slavery in the United States. Some Northeastern states still had small amounts of slaves into the 1850s, though some would ban it during the decade. The election of 1860 led to the start of the Civil War; southern states seceded from the United States in late-1860 and early-1861. States like Maryland and Delaware would remain in

10412-522: The Northeast is Mount Washington in New Hampshire at 6,288 feet (1,917 m). As of 2012 , forest-use covered approximately 60% of the Northeastern states, including Delaware, Maryland, and Washington, D.C., about twice the national average. About 11% was cropland and another 4% grassland pasture or range. There is also more urbanized land in the Northeast (12%) than any other region in

10549-505: The Northeast, and frequent (but brief) thundershowers are common on hot summer days. In winter, the subtropical high retreats southeastward, and the polar jet stream moves south bringing colder air masses from up in Canada and more frequent storm systems to the region. Winter often brings both rain and snow as well as surges of both warm and cold air. In the southern part of the Northeast from coastal Rhode Island southwest to eastern Maryland,

10686-584: The Northeast. For the most part, the people of the Northeastern Woodlands, on whose lands European fishermen began camping to dry their codfish in the early 1600s, lived in villages, especially after being influenced by agricultural traditions of the Ohio and Mississippi valley societies. All of the U.S. states making up the Northeastern region were among the original Thirteen Colonies , though Maine and Vermont were part of other colonies before

10823-580: The Northeast. The British would evacuate Boston in early-1776 and would move to capture New York City . The revolutionaries were pushed to the Delaware River before suddenly moving forward against the British in the Battles of Trenton and Princeton . A stalemate was reached in 1778, between the British and American Revolutionaries and continued until the end of the war in 1783. The war would move to southern states and eventually conclude with

10960-664: The Northeastern United States in somewhat different ways. The Association of American Geographers divides the Northeast into two divisions: "New England", which is the same as the Census Bureau; and it has the same "Middle States" but adds Delaware. Similarly, the Geological Society of America defines the Northeast as these same states but with the addition of Maryland and the District of Columbia . The narrowest definitions include only

11097-596: The Pennsylvania portion of the Delaware Valley including Philadelphia , Delaware , and most of Maryland . In the latter region the hardiness zone ranges from 7a to 8a. Annual mean temperatures range from the low-to-mid 50s F from Maryland to southern Connecticut, to the 40s F in most of New York State, New England, and northern Pennsylvania. Most of the Northeast has a humid continental climate ( Dfa/Dfb/occasional Dfc/Dc ). The northernmost portion of

11234-720: The U.S. Many parks on a state and national level cover the inland parts of the region. Large parks include the Adirondack Park in northeastern New York, Green Mountain National Forest in Vermont, White Mountain Forest in northern New Hampshire, Baxter State Park in northern Maine, Acadia National Park on the eastern coast of Maine, Allegheny National Forest in northwestern Pennsylvania, and Catskill Park in southern New York. There are also some parks closer to

11371-503: The U.S. and Northern European population. Other loci exhibit a protective effect, such as HLA-C554 and HLA-DRB1 *11 . HLA differences account for an estimated 20 to 60% of the genetic predisposition . Genome-wide association studies have revealed at least 200 MS-associated variants outside the HLA locus . The prevalence of MS from a geographic standpoint resembles a gradient, with it being more common in people who live farther from

11508-596: The United States (western and Northeastern states) and the Confederacy (southeastern states). The admission of Maine as a free state in exchange for Missouri becoming a slave state as part of the Missouri Compromise in 1820 would settle the final boundaries of the Northeastern states. The Mason-Dixon line would be established as the border of slavery, following the border of Pennsylvania and Delaware/Maryland. Abolitionist movements would start in

11645-755: The United States became independent in the American Revolution . The two cultural and geographic regions that form parts of the Northeastern region have distinct histories. The first European explorer known to have explored the Atlantic shoreline of the Northeast since the Norse was Giovanni da Verrazzano in 1524. His ship La Dauphine explored the coast from what is now known as Florida to New Brunswick. The first Europeans to settle and colonize New England were Pilgrims from England , who landed in present-day Massachusetts in 1620. The Pilgrims arrived on

11782-508: The United States during the war, conflicts did arise, like the New York draft riots in 1863. The war would end in 1865 with the United States taking back control of Southern states. Following the Civil War, the Northeast would see a large economic boom and would become one of the most industrialized regions in the world. Many technological innovations would be made in the Northeast during this time. The Second Industrial Revolution would see

11919-714: The United States. The War of 1812 would see less fighting in the Northeast and instead more fighting in western and southern areas. A failed invasion of Canada and the occupation of Maine would be some of the major conflicts during the war. The war would end in 1815 and most of the Northeast has not seen any major conflict since then. The American Industrial Revolution was launched in Blackstone Valley in Rhode Island and Massachusetts , where textile mills spread across New England, and in eastern Pennsylvania , where coal, steel, and industrialization launched

12056-561: The United States. In a 2009 Gallup survey, less than half of residents in Maine , Massachusetts , New Hampshire , and Vermont reported religion as an important part of their daily life. In a 2010 Gallup survey, less than 30% of residents in Vermont, New Hampshire, Maine, and Massachusetts reported attending church weekly, giving them the lowest church attendance among U.S. states. The vast area from central Virginia to northern Maine , and from western Pennsylvania , from Pittsburgh in

12193-475: The ages of 20 and 50 and is twice as common in women as in men. MS was first described in 1868 by French neurologist Jean-Martin Charcot . The name "multiple sclerosis " is short for multiple cerebro-spinal sclerosis , which refers to the numerous glial scars (or sclerae – essentially plaques or lesions) that develop on the white matter of the brain and spinal cord. As MS lesions can affect any part of

12330-569: The area became known as New Netherland . In 1625, the city of New Amsterdam (the location of present-day New York City) was designated the capital of the province. The Dutch New Netherland settlement along the Hudson River and, for a time, the New Sweden settlement along the Delaware River divided the English settlements in the north and the south. In 1664, Charles II of England formally annexed New Netherland and incorporated it into

12467-421: The body. The peripheral nervous system is rarely involved. To be specific, MS involves the loss of oligodendrocytes , the cells responsible for creating and maintaining a fatty layer—known as the myelin sheath—which helps the neurons carry electrical signals (action potentials). This results in a thinning or complete loss of myelin, and as the disease advances, the breakdown of the axons of neurons. When

12604-473: The brain. Gadolinium cannot cross a normal BBB, so gadolinium-enhanced MRI is used to show BBB breakdowns. The pathophysiology and mechanisms causing MS fatigue are not well understood. MS fatigue can be affected by body heat, and this may differentiate MS fatigue from other primary fatigue. Fatigability (loss of strength) may increase perception of fatigue, but the two measures warrant independent assessment in clinical studies. Multiple sclerosis

12741-607: The components of the regions and divisions to ensure that they continue to represent the most useful combinations of states and state equivalents." Many organizations and reference works follow the Census Bureau's definition for the region. In the history of the United States, the Mason–Dixon line between Pennsylvania ( the North ) and Maryland ( the South ) traditionally divided the regions, but in modern times, various entities define

12878-546: The discontinuation two months before of WGN-TV's 9 p.m. newscast from WGN America, the same numbers applied to those playing the same games in neighboring Iowa ; that state now draws their own numbers. Lucky Day Lotto (5/45) , with a minimum jackpot of $ 100,000, is drawn twice a day. In 2009, the Illinois legislature passed amendments to the Lottery Law that approved the Internet Pilot Program to launch

13015-473: The disease advances. In progressive forms of MS, bodily function slowly deteriorates once symptoms manifest and will steadily worsen if left untreated. While its cause is unclear, the underlying mechanism is thought to be due to either destruction by the immune system or inactivation of myelin-producing cells. Proposed causes for this include immune dysregulation, genetics , and environmental factors, such as viral infections . The McDonald criteria are

13152-449: The disease is "sparse and unpersuasive". Gout occurs less than would be expected and lower levels of uric acid have been found in people with MS. This has led to the theory that uric acid is protective, although its exact importance remains unknown. Obesity during adolescence and young adulthood is a risk factor for MS. Multiple sclerosis is an autoimmune disease, primarily mediated by T-cells. The three main characteristics of MS are

13289-401: The formation of lesions in the central nervous system (also called plaques), inflammation, and the destruction of myelin sheaths of neurons . These features interact in a complex and not yet fully understood manner to produce the breakdown of nerve tissue, and in turn, the signs and symptoms of the disease. Damage is believed to be caused, at least in part, by attack on the nervous system by

13426-472: The game used a Beitel Criterion drawing machine. On November 7, 1994, five of the possible numbers were removed from the game(with the matrix becoming 5/30). Little Lotto became a Monday-through-Friday game beginning with the August 4, 1998 drawing. On February 25, 2004, the number matrix for "Little Lotto" changed again, to 5/39, with jackpots beginning at $ 100,000; the game's drawing also expanded to seven days

13563-640: The game was ended before the lottery sold most of the printed tickets. In January 2018, the Camelot Group , a gaming company based in the United Kingdom owned by the Ontario Teachers' Pension Plan , became the new operator of the Illinois Lottery. The state of Illinois was the first in the US to privatize its lottery system. Illinois Lottery proceeds currently benefit three major areas: 1)

13700-540: The global distribution of these high-risk populations. A relationship between season of birth and MS lends support to this idea, with fewer people born in the Northern Hemisphere in November compared to May being affected later in life. Environmental factors may play a role during childhood, with several studies finding that people who move to a different region of the world before the age of 15 acquire

13837-423: The level of cognitive impairment varies considerably between people with MS. Uhthoff's phenomenon , a worsening of symptoms due to exposure to higher-than-usual temperatures, and Lhermitte's sign , an electrical sensation that runs down the back when bending the neck, are particularly characteristic of MS, although may not always be present. Another presenting manifestation that is rare but highly suggestive of

13974-662: The locations of the lesions within the nervous system, and may include focal loss of sensitivity or changes in sensation in the limbs, such as feeling tingling, pins and needles, or numbness; limb motor weakness/pain, blurred vision , pronounced reflexes , muscle spasms , difficulty with ambulation (walking), difficulties with coordination and balance ( ataxia ); problems with speech or swallowing , visual problems ( optic neuritis manifesting as eye pain & vision loss, or nystagmus manifesting as double vision ), fatigue, and bladder and bowel difficulties (such as urinary or fecal incontinence or retention), among others. When MS

14111-408: The loss of myelin, or they may cause the axon to break down completely. The blood–brain barrier (BBB) is a part of the capillary system that prevents the entry of T cells into the central nervous system. It may become permeable to these types of cells secondary to an infection by a virus or bacteria. After it repairs itself, typically once the infection has cleared, T cells may remain trapped inside

14248-473: The lottery, including games based on licensed properties such as the NBC game show Deal or No Deal . Chicago and St. Louis area sports teams also have tie-ins with the Lottery. On September 6, 1996, six U.S. lotteries, including Illinois', launched The Big Game . Six years later, The Big Game added Mega Millions to its name; the game now is known simply as Mega Millions . Mega Millions' minimum jackpot

14385-461: The moment of the evaluation. Central vein signs (CVSs) have been proposed as a good indicator of MS in comparison with other conditions causing white lesions. One small study found fewer CVSs in older and hypertensive people. Further research on CVS as a biomarker for MS is ongoing. Only postmortem MRI allows visualization of sub-millimetric lesions in cortical layers and in the cerebellar cortex. Testing of cerebrospinal fluid obtained from

14522-438: The move as fraud. In 2015, the Illinois Lottery became the subject of a class-action seeking to recoup the monies not paid since the suspension of payouts, including a group of players owed at least $ 288.4 million. On December 7, 2015, Illinois's governor, Bruce Rauner , signed legislation which allowed for the resumption of all payouts. Pick 3 (originally known as The Daily Game ) launched on February 19, 1980. It started out as

14659-403: The myelin is lost, a neuron can no longer effectively conduct electrical signals. A repair process, called remyelination , takes place in early phases of the disease, but the oligodendrocytes are unable to completely rebuild the cell's myelin sheath. Repeated attacks lead to successively less effective remyelinations, until a scar-like plaque is built up around the damaged axons. These scars are

14796-767: The nation's manufacturing sector. After the end of the War of 1812, industry boomed in the Northeast in the early and middle parts of the 19th century. With the construction of railroad and canals crossing the northeast and the rise of western territories and resources from the south, the Northeast experienced the development of new industries and a fast-growing population. Many of the coastal cities, including Boston , New York City , and Philadelphia , served as ocean trade ports for American goods. Cities, including Allentown , Buffalo , Pittsburgh , Rochester , and Syracuse , were settled and emerged as major industrial centers. By 1860, New York City, based on its present-day boundaries,

14933-548: The new region's risk of MS. If migration takes place after age 15, the persons retain the risk of their home country. Some evidence indicates that the effect of moving may still apply to people older than 15. There are some exceptions to the above mentioned geographic pattern. These include ethnic groups that are at low risk and that live far from the equator such as the Sami , Amerindians , Canadian Hutterites , New Zealand Māori , and Canada's Inuit , as well as groups that have

15070-405: The northeast grow massively, even more so than before the Civil War. Many cities in the Northeast would explode in population, with cities like Philadelphia and New York climbing over one million people, while other cities like Buffalo, Boston, and Pittsburgh would rise above half a million during this time. New York City eventually grew to become one of the largest cities in the world by 1900. With

15207-502: The origin of the symptoms and during an attack magnetic resonance imaging (MRI) often shows more than 10 new plaques. This could indicate that some number of lesions exist, below which the brain is capable of repairing itself without producing noticeable consequences. Another process involved in the creation of lesions is an abnormal increase in the number of astrocytes due to the destruction of nearby neurons. A number of lesion patterns have been described. Apart from demyelination,

15344-529: The other sign of the disease is inflammation . Fitting with an immunological explanation, the inflammatory process is caused by T cells , a kind of lymphocytes that plays an important role in the body's defenses. T cells gain entry into the brain as a result of disruptions in the blood–brain barrier . The T cells recognize myelin as foreign and attack it, explaining why these cells are also called "autoreactive lymphocytes". The attack on myelin starts inflammatory processes, which trigger other immune cells and

15481-427: The pathogenesis of multiple sclerosis, but not all people with MS have signs of EBV infection. Dozens of human peptides have been identified in different cases of the disease, and while some have plausible links to infectious organisms or known environmental factors, others do not. Failure of both central and peripheral nervous system clearance of autoreactive immune cells is implicated in MS development. The thymus

15618-440: The region as including the six New England states of Connecticut , Maine , Massachusetts , New Hampshire , Rhode Island , and Vermont , and three northern Mid-Atlantic states of New Jersey , New York , and Pennsylvania . The region is home to the Northeast megalopolis , which includes many of the nation's largest metropolitan areas, including Boston , New York City , and Philadelphia . The megalopolis makes up 67% of

15755-517: The region's total population of 57,609,148. The gross domestic product of the region was $ 5.1 trillion as of 2022 and contains some of the most developed states based on the Human Development Index , with every state with the exception of Maine above the national average. It is also the most densely populated region in the United States, with 320 people per square mile (120 people/km ). The U.S. Census Bureau defines

15892-474: The region. The climate of the Northeastern United States varies from northernmost state of Maine to its southernmost state in Maryland . The region's climate is influenced by its positional western to eastern flow of weather in the middle latitudes in the United States. Summers are normally warm in northern areas to hot in southern areas. In summer, the building Bermuda High pumps warm and sultry air toward

16029-501: The release of soluble factors like cytokines and antibodies . A further breakdown of the blood-brain barrier, in turn, causes a number of other damaging effects, such as swelling , activation of macrophages , and more activation of cytokines and other destructive proteins. Inflammation can potentially reduce transmission of information between neurons in at least three ways. The soluble factors released might stop neurotransmission by intact neurons. These factors could lead to or enhance

16166-587: The revolution the Northeast would see small skirmishes like the Whiskey Rebellion in western parts of Pennsylvania. Many northeastern states would continue trading with the British and other European powers. Tensions between the United States and Europe (specifically Britain) would sour in the lead up to the War of 1812 . This caused certain trade merchants to meet in Hartford to propose succeeding from

16303-422: The sale of the Mega Millions and Lotto games on the Internet. The Illinois Lottery suspended the sale of Mega Millions tickets as the state's General Assembly struggled to pass a budget including lottery funding for the 2018 fiscal year. On December 23, 2011, a U.S. Justice Department decision provided much anticipated clarity to Illinois' and other U.S. lotteries by confirming that the sale of lottery products over

16440-404: The scars (sclerae – better known as plaques or lesions) that form in the nervous system. These lesions most commonly affect the white matter in the optic nerve , brain stem , basal ganglia , and spinal cord , or white matter tracts close to the lateral ventricles . The function of white matter cells is to carry signals between grey matter areas, where the processing is done, and the rest of

16577-639: The sea for the Province of Pennsylvania and leased what then came to be known as the "Lower Counties on the Delaware" from the Duke . Penn established representative government and briefly combined his two possessions under one General Assembly in 1682. By 1704, the province of Pennsylvania had grown so large that their representatives wanted to make decisions without the assent of the Lower Counties and

16714-484: The ship Mayflower and founded Plymouth Colony so they could practice religion freely. Ten years later, a larger group of Puritans settled north of Plymouth Colony in Boston to form Massachusetts Bay Colony . In 1636, colonists established Connecticut Colony and Providence Plantations . Providence was founded by Roger Williams , who was banished by Massachusetts for his beliefs in freedom of religion, and it

16851-679: The shore, though these are usually smaller and squeezed in-between urbanized areas. These include the Palisades Park in New Jersey, Fire Island in Long Island, and the Cape Cod shoreline in Massachusetts. The Northeast has 72 National Wildlife Refuges , encompassing more than 500,000 acres (780 sq mi; 2,000 km ) of habitat and designed to protect some of the 92 different threatened and endangered species living in

16988-424: The state's Common School Fund (CSF), which helps finance K–12 public schools; 2) The Capital Projects Fund, used for infrastructure improvements and job creation and 3) special causes like Illinois veterans, breast cancer charities and research, assistance for people living with HIV/AIDS, and multiple sclerosis research. Each of the four special causes above is funded by a unique instant scratch-off game authorized by

17125-555: The states of New England. Other more restrictive definitions include New England and New York as part of the Northeast United States, but exclude Pennsylvania and New Jersey. States beyond the Census Bureau definition are included in Northeast Region by various other entities: While most of the Northeastern United States lie in the physiographic region of the Appalachian Highlands , some are also part of

17262-433: The two groups of representatives began meeting on their own, one at Philadelphia , and the other at New Castle, Delaware . Penn and his heirs remained proprietors of both and always appointed the same person Governor for their province of Pennsylvania and their territory of the Lower Counties. The fact that Delaware and Pennsylvania shared the same governor was not unique. From 1703 to 1738, both New York and New Jersey shared

17399-580: The union, even with slavery still legal. For the first two years, the eastern theater of the war would remain in Virginia and Maryland, but in 1863 the war would reach its northeastern most extent in Gettysburg, Pennsylvania . The Battle of Gettysburg is considered a turning point in the Civil War, seeing the end of the Confederate push northwards. While all Northeastern states would remain in

17536-400: The west to the Atlantic Ocean in the east, have all been loosely grouped into the Northeast. The U.S. Census Bureau 's definition of the Northeast includes nine states: Maine , New York , New Jersey , Vermont , Massachusetts , Rhode Island , Connecticut , New Hampshire , and Pennsylvania . The region is often subdivided into New England , the six states east of New York state and

17673-415: Was 20.5% under age 18, 57.36% from 18 to 62, and 22.1% who were 62 years of age or older. The median age was 40.5 years. For every 100 females, there were 96.4 males. For every 100 women ages 18 and over, there were 94.3 men. Multiple sclerosis Multiple sclerosis ( MS ) is an autoimmune disease resulting in damage to the insulating covers of nerve cells in the brain and spinal cord . As

17810-429: Was 64.42% white , 11.51% African American, 0.51% Native American, 7.25% Asian, 0.04% Pacific Islander, 8.17% from other races, and 8.10% from two or more races. Hispanic or Latino of any race were 15.27% of the population. There were 22,418,883 households and 14,189,719 families in 2021. Of the 22,418,883 households, 27.7% included children under the age of 18. In 2021, the region's the population's age distribution

17947-522: Was held in Philadelphia, where the new United States Constitution was drafted in 1787. 6 of the first 13 states to ratify the new constitution would be in the Northeast, with the last of the original 13, Rhode Island, ratifying the constitution in 1790. Vermont would be admitted in 1791 as the 14th state. The first Congress would convene in Federal Hall in New York City in March 1789. Following

18084-461: Was played by picking 12 numbers from 1 to 24 for each game played. Unlike the All or Nothing concept and format, players also had an additional number selected at random called the life ball number(from 1 to 5) which only applied to the game’s top prize which was $ 250,000. Players who match all or none of the numbers drawn with the good life number won the top prize and $ 100,000 a year for life (the $ 100,000

18221-585: Was removed from WGN America in February 2014 as they begin their transition to a general cable network. The Illinois Lottery is one of 45 lottery jurisdictions that participate in Mega Millions and Powerball – of these jurisdictions, 44 of the 45 lotteries offer both games. The Lottery also offers Lotto with a smaller jackpot, which is drawn on Monday, Thursday and Saturday nights. Pick 3 and Pick 4 numbers are drawn twice daily. Until April 16, 2014, with

18358-528: Was separate from "Pick 3", allowed players to choose numbers without the need to specify the type of wager being made. Players had to match all three digits in exact order to win $ 200. Lesser amounts were won depending on the order in which three digits were drawn. The final "My 3" drawing was on September 14, 2014. This game had a similar title to the All or Nothing game (although it made its way to Illinois in September 2013 with an unknown end date). The game

18495-534: Was the first U.S. city to reach a population exceeding one million. Due to the settlement of the Midwest and Great Plains , agriculture would collapse in the Mid-Atlantic and New England, with many farms being abandoned by the end of the century, returning to rural forest. Conflicts with the south over the spread of slavery would become a large factor in the start of the American Civil War, between

18632-564: Was the first colony to guarantee all citizens freedom of worship. Anne Hutchinson , who was also banished by Massachusetts, formed the town of Portsmouth . Providence, Portsmouth and two other towns ( Newport and Warwick ) consolidated to form the Colony of Rhode Island and Providence Plantations . Henry Hudson explored the area of present-day New York in 1609 and claimed it for the Netherlands. His journey stimulated Dutch interest, and

18769-415: Was won by an Illinois resident who purchased their ticket via the Illinois State Lottery's online platform. On October 1, 2015, the Illinois Lottery started determining the winning numbers electronically, using a computer with a random number generator , instead of using machines with numbered balls; furthermore, live draws were no longer televised, but rather posted on the Illinois Lottery's website, and on

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