The Jackling House was a mansion in Woodside, California , designed and built for copper mining magnate Daniel Cowan Jackling and his family by noted California architect George Washington Smith in 1925.
129-399: Though it was considered a historic home, it was demolished in 2011 by its last owner, Steve Jobs . Its demolition followed a protracted court battle during which Jobs stated his intentions to build a smaller, contemporary-styled home on the site, though he died before any plans could be realized. The Jackling House designer, George Washington Smith , was the foremost creator and proponent of
258-453: A Lutheran church. When Steve was in high school, Clara admitted to his girlfriend, Chrisann Brennan , that she "was too frightened to love [Steve] for the first six months of his life ... I was scared they were going to take him away from me. Even after we won the case, Steve was so difficult a child that by the time he was two I felt we had made a mistake. I wanted to return him." When Chrisann shared this comment with Steve, he stated that he
387-444: A MEN1 mutation eventually develop a PanNet. Other genes that are frequently mutated include DAXX , mTOR , and ATRX . The symptoms of pancreatic adenocarcinoma do not usually appear in the disease's early stages, and they are not individually distinctive to the disease. The symptoms at diagnosis vary according to the location of the cancer in the pancreas, which anatomists divide (from left to right on most diagrams) into
516-465: A closed adoption , and travelled to San Francisco to give birth. Schieble requested that her son be adopted by college graduates. A lawyer and his wife were selected, but they withdrew after discovering that the baby was a boy, so Jobs was instead adopted by Paul Reinhold and Clara (née Hagopian) Jobs. Paul Jobs, an American of German descent, was the son of a dairy farmer from Washington County, Wisconsin . After dropping out of high school, he worked as
645-495: A computer platform development company that specialized in computers for higher-education and business markets, serving as its CEO. In 1986, he helped develop the visual effects industry by funding the computer graphics division of Lucasfilm that eventually spun off independently as Pixar, which produced the first 3D computer-animated feature film Toy Story (1995) and became a leading animation studio , producing 28 films since. In 1997, Jobs returned to Apple as CEO after
774-534: A repossession agent, and Clara became a bookkeeper . In 1955, after having an ectopic pregnancy , the couple looked to adopt a child. Since they lacked a college education, Schieble initially refused to sign the adoption papers, and went to court to request that her son be removed from the Jobs household and placed with a different family, but changed her mind after Paul and Clara promised to pay for their son's college tuition. In his youth, Jobs's parents took him to
903-402: A tumor microenvironment that is short of blood vessels (hypovascular) and so of oxygen ( tumor hypoxia ). It is thought that this prevents many chemotherapy drugs from reaching the tumor, as one factor making the cancer especially hard to treat. Negative for: Pancreatic cancer is usually staged following a CT scan . The most widely used cancer staging system for pancreatic cancer
1032-406: A Homestead classmate as "kind of brain and kind of hippie ... but he never fit into either group. He was smart enough to be a nerd, but wasn't nerdy. And he was too intellectual for the hippies, who just wanted to get wasted all the time. He was kind of an outsider. In high school everything revolved around what group you were in, and if you weren't in a carefully defined group, you weren't anybody. He
1161-421: A better prognosis than the other exocrine types. Pancreatoblastoma is a rare form, mostly occurring in childhood, and with a relatively good prognosis. Other exocrine cancers include adenosquamous carcinomas , signet ring cell carcinomas , hepatoid carcinomas , colloid carcinomas, undifferentiated carcinomas, and undifferentiated carcinomas with osteoclast -like giant cells . Solid pseudopapillary tumor
1290-496: A built in residence pipe organ , originally constructed by the Aeolian Company and later enlarged by George Kilgen and Sons . George Washington Smith integrated the 17,000 sq ft (1,600 m) residence and landscaped gardens with a large traditional courtyard, open-air balconies, and many indoor-outdoor sightline and access connections. Details about the house and its contents when Jackling lived there, including
1419-590: A chandelier, wall sconces, door handles, a flagpole, and a 1920s thermostat and toilet – in sequence to the town first, and then to the owners of another Smith-designed home next door. After that, the items would be offered to the museum of the University of California, Santa Barbara , which has additional Smith designs nearby. Remaining items would then be made available to the public via silent auction before being "sent to salvage". Steve Jobs Steven Paul Jobs (February 24, 1955 – October 5, 2011)
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#17327719838781548-410: A combination of medical imaging techniques such as ultrasound or computed tomography , blood tests, and examination of tissue samples ( biopsy ). The disease is divided into stages , from early (stage I) to late (stage IV). Screening the general population has not been found to be effective. The risk of developing pancreatic cancer is lower among non-smokers, and people who maintain
1677-401: A combination of these. Treatment options are partly based on the cancer stage. Surgery is the only treatment that can cure pancreatic adenocarcinoma, and may also be done to improve quality of life without the potential for cure. Pain management and medications to improve digestion are sometimes needed. Early palliative care is recommended even for those receiving treatment that aims for
1806-401: A considerably increased risk remains of pancreatic cancer developing subsequently. The third type, pancreatic mucinous cystic neoplasm (MCN), mainly occurs in women, and may remain benign or progress to cancer. If these lesions become large, cause symptoms, or have suspicious features, they can usually be successfully removed by surgery. A fourth type of cancer that arises in the pancreas
1935-456: A cure or to alleviate symptoms. Risk factors for pancreatic adenocarcinoma include: Drinking alcohol excessively is a major cause of chronic pancreatitis , which in turn predisposes to pancreatic cancer, but considerable research has failed to firmly establish alcohol consumption as a direct risk factor for pancreatic cancer. Overall, the association is consistently weak and the majority of studies have found no association, with smoking
2064-541: A cure. Pancreatic cancer is among the most deadly forms of cancer globally, with one of the lowest survival rates. In 2015, pancreatic cancers of all types resulted in 411,600 deaths globally. Pancreatic cancer is the fifth-most-common cause of death from cancer in the United Kingdom, and the third most-common in the United States. The disease occurs most often in the developed world, where about 70% of
2193-420: A decade. After that, he leased it out for several years until 2000 when he stopped maintaining the house, allowing exposure to the weather to degrade it. In 2004, Jobs received permission from the town of Woodside to demolish the house in order to build a smaller, contemporary styled one. Local preservationists created a new group, "Uphold Our Heritage" (UOH), dedicated to saving the historic residence. They sued
2322-481: A female name (his first choice was "Claire" after St. Clare ). She stated that she never gave him permission to use the baby's name for a computer and he hid the plans from her. Jobs worked with his team to come up with the phrase, "Local Integrated Software Architecture" as an alternative explanation for the Apple Lisa . Decades later, however, Jobs admitted to his biographer Walter Isaacson that "obviously, it
2451-513: A hammer so I could work with him ... I wasn't that into fixing cars ... but I was eager to hang out with my dad." Jobs had difficulty functioning in a traditional classroom, tended to resist authority figures, frequently misbehaved, and was suspended a few times. He frequently played pranks on others at Monta Loma Elementary School in Mountain View. His father Paul (who was abused as a child) never reprimanded him, however, and instead blamed
2580-509: A healthy weight and limit their consumption of red or processed meat ; the risk is greater for men, smokers, and those with diabetes. There is some evidence that links high levels of red meat consumption to increased risk of pancreatic cancer. Smokers' risk of developing the disease decreases immediately upon quitting, and almost returns to that of the rest of the population after 20 years. Pancreatic cancer can be treated with surgery, radiotherapy , chemotherapy , palliative care , or
2709-545: A house from their other roommate, Al. In September 1972, Jobs enrolled at Reed College in Portland, Oregon . He insisted on applying only to Reed, although it was an expensive school that Paul and Clara could ill afford. Jobs soon befriended Robert Friedland , who was Reed's student body president at that time. Brennan remained involved with Jobs while he was at Reed. I was interested in Eastern mysticism which hit
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#17327719838782838-460: A humanities person as a kid, but I liked electronics... then I read something that one of my heroes, Edwin Land of Polaroid , said about the importance of people who could stand at the intersection of humanities and sciences, and I decided that's what I wanted to do. —Steve Jobs Paul Jobs worked in several jobs that included a try as a machinist, several other jobs, and then "back to work as
2967-637: A lifelong friendship with Jobs. By early 1985, the Macintosh's failure to defeat the IBM PC became clear, and it strengthened Sculley's position in the company. In May 1985, Sculley—encouraged by Arthur Rock—decided to reorganize Apple, and proposed a plan to the board that would remove Jobs from the Macintosh group and put him in charge of "New Product Development". This move would effectively render Jobs powerless within Apple. In response, Jobs then developed
3096-556: A machinist". Paul and Clara adopted Jobs's sister Patricia in 1957, and by 1959 the family had moved to the Monta Loma neighborhood in Mountain View, California . Paul built a workbench in his garage for his son in order to "pass along his love of mechanics". Jobs, meanwhile, admired his father's craftsmanship "because he knew how to build anything. If we needed a cabinet, he would build it. When he built our fence, he gave me
3225-607: A mechanic, then joined the US Coast Guard . When his ship was decommissioned at San Francisco, he bet he could find a wife within two weeks. He then met Clara Hagopian, an American of Armenian descent, and the two were engaged ten days later, in March 1946, and married that same year. The couple moved to Wisconsin, then Indiana, where Paul Jobs worked as a machinist and later as a car salesman. Since Clara missed San Francisco, she convinced Paul to move back. There, Paul worked as
3354-483: A new building for the site in 2016. The Woodside History Museum has an exhibit of furniture, maps, photographs, etc. from the Jackling House. The town of Woodside collected 150 items from the home before it was destroyed. As of October 2018, the items were reportedly appraised at over $ 30,000. At a meeting that month, the town council approved a plan to offer the items – including a silver-plated teaspoon,
3483-663: A plan to get rid of Sculley and take over Apple. However, Jobs was confronted after the plan was leaked, and he said that he would leave Apple. The Board declined his resignation and asked him to reconsider. Sculley also told Jobs that he had all of the votes needed to go ahead with the reorganization. A few months later, on September 17, 1985, Jobs submitted a letter of resignation to the Apple Board. Five additional senior Apple employees also resigned and joined Jobs in his new venture, NeXT. The Macintosh's struggle continued after Jobs left Apple. Though marketed and received in fanfare,
3612-505: A smaller, contemporary styled one. After a few years in court, the house was finally demolished in 2011, a few months before he died. Jobs took over development of the Macintosh in 1981, from early Apple employee Jef Raskin , who had conceived the project. Wozniak and Raskin had heavily influenced the early program, and Wozniak was on leave during this time due to an airplane crash earlier that year, making it easier for Jobs to take over
3741-545: A strong confounding factor. The evidence is stronger for a link with heavy drinking, of at least six drinks per day. Exocrine cancers are thought to arise from several types of precancerous lesions within the pancreas, but these lesions do not always progress to cancer, and the increased numbers detected as a byproduct of the increasing use of CT scans for other reasons are not all treated. Apart from pancreatic serous cystadenomas , which are almost always benign, four types of precancerous lesion are recognized. The first
3870-519: A sufficient quantity to give rise to overt clinical symptoms, so nonfunctioning PanNETs are often diagnosed only after the cancer has spread to other parts of the body. As with other neuroendocrine tumors, the history of the terminology and classification of PanNETs is complex. PanNETs are sometimes called "islet cell cancers", though they are now known to not actually arise from islet cells as previously thought. Since pancreatic cancer usually does not cause recognizable symptoms in its early stages,
3999-606: A whole lot, and I started to read more outside of just science and technology — Shakespeare , Plato . I loved King Lear ... when I was a senior I had this phenomenal AP English class . The teacher was this guy who looked like Ernest Hemingway . He took a bunch of us snowshoeing in Yosemite." During his last two years at Homestead High, Jobs developed two different interests: electronics and literature. These dual interests were particularly reflected during Jobs's senior year, as his best friends were Wozniak and his first girlfriend,
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4128-469: Is a rare low- grade neoplasm that mainly affects younger women, and generally has a very good prognosis. Pancreatic mucinous cystic neoplasms are a broad group of pancreas tumors that have varying malignant potential. They are being detected at a greatly increased rate as CT scans become more powerful and common, and discussion continues as how best to assess and treat them, given that many are benign. The small minority of tumors that arise elsewhere in
4257-457: Is accompanied by typical symptoms such as unexplained weight loss, persistent abdominal or back pain, indigestion, vomiting, or fatty feces. Jaundice accompanied by a painlessly swollen gallbladder (known as Courvoisier's sign ) may also raise suspicion, and can help differentiate pancreatic cancer from gallstones . Medical imaging techniques, such as computed tomography (CT scan) and endoscopic ultrasound (EUS) are used both to confirm
4386-453: Is by far the most common type, representing about 85% of all pancreatic cancers. Nearly all these start in the ducts of the pancreas, as pancreatic ductal adenocarcinoma (PDAC). This is despite the fact that the tissue from which it arises – the pancreatic ductal epithelium – represents less than 10% of the pancreas by cell volume, because it constitutes only the ducts (an extensive but capillary-like duct-system fanning out) within
4515-410: Is less sensitive and will miss small tumors, but can identify cancers that have spread to the liver and build-up of fluid in the peritoneal cavity ( ascites ). It may be used for a quick and cheap first examination before other techniques. A biopsy by fine needle aspiration , often guided by endoscopic ultrasound, may be used where there is uncertainty over the diagnosis, but a histologic diagnosis
4644-456: Is not usually required for removal of the tumor by surgery to go ahead. Liver function tests can show a combination of results indicative of bile duct obstruction (raised conjugated bilirubin , γ-glutamyl transpeptidase and alkaline phosphatase levels). CA19-9 (carbohydrate antigen 19.9) is a tumor marker that is frequently elevated in pancreatic cancer. However, it lacks sensitivity and specificity , not least because 5% of people lack
4773-485: Is pancreatic intraepithelial neoplasia (PanIN). These lesions are microscopic abnormalities in the pancreas and are often found in autopsies of people with no diagnosed cancer. These lesions may progress from low to high grade and then to a tumor. More than 90% of cases at all grades carry a faulty KRAS gene, while in grades 2 and 3, damage to three further genes – CDKN2A ( p16 ), p53 , and SMAD4 – are increasingly often found. A second type
4902-428: Is technically feasible because the celiac axis and superior mesenteric artery are still free) and those that are "unresectable" (due to more locally advanced disease); in terms of the more detailed TNM classification, these two groups correspond to T3 and T4 respectively. Locally advanced adenocarcinomas have spread into neighboring organs, which may be any of the following (in roughly decreasing order of frequency):
5031-513: Is the intraductal papillary mucinous neoplasm (IPMN). These are macroscopic lesions, which are found in about 2% of all adults. This rate rises to about 10% by age 70. These lesions have about a 25% risk of developing into invasive cancer. They may have KRAS gene mutations (40–65% of cases) and in the GNAS Gs alpha subunit and RNF43, affecting the Wnt signaling pathway . Even if removed surgically,
5160-574: Is the intraductal tubulopapillary neoplasm. This type was recognised by the WHO in 2010 and constitutes about 1–3% of all pancreatic neoplasms. Mean age at diagnosis is 61 years (range 35–78 years). About 50% of these lesions become invasive. Diagnosis depends on histology, as these lesions are very difficult to differentiate from other lesions on either clinical or radiological grounds. The genetic events found in ductal adenocarcinoma have been well characterized, and complete exome sequencing has been done for
5289-700: Is the one formulated by the American Joint Committee on Cancer (AJCC) together with the Union for International Cancer Control (UICC). The AJCC-UICC staging system designates four main overall stages, ranging from early to advanced disease, based on TNM classification of T umor size, spread to lymph N odes, and M etastasis. To help decide treatment, the tumors are also divided into three broader categories based on whether surgical removal seems possible: in this way, tumors are judged to be "resectable", "borderline resectable", or "unresectable". When
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5418-426: Is typically characterized by moderately to poorly differentiated glandular structures on microscopic examination. There is typically considerable desmoplasia or formation of a dense fibrous stroma or structural tissue consisting of a range of cell types (including myofibroblasts , macrophages , lymphocytes and mast cells ) and deposited material (such as type I collagen and hyaluronic acid ). This creates
5547-557: The Lewis (a) antigen and cannot produce CA19-9. It has a sensitivity of 80% and specificity of 73% in detecting pancreatic adenocarcinoma, and is used for following known cases rather than diagnosis. All those with pancreatic cancer require genetic testing as high risk oncogenic mutations may provide prognostic information and certain mutations with high risk features require first degree relatives to undergo genetic testing as well. The most common form of pancreatic cancer (adenocarcinoma)
5676-697: The Spanish Colonial Revival architectural style that became popular in the U.S. and remains so, especially in California and the Southwest. Based in Montecito , Smith helped create Santa Barbara 's unified city planning and architectural aesthetic and many significant residences in the area in the 1920s. Daniel Jackling was a copper mining baron, and the estate represented his aesthetic values, wealth, and family needs. It contained
5805-443: The duodenum , stomach , transverse colon , spleen , adrenal gland , or kidney . Very often they also spread to the important blood or lymphatic vessels and nerves that run close to the pancreas, making surgery far more difficult. Typical sites for metastatic spread (stage IV disease) are the liver, peritoneal cavity and lungs , all of which occur in 50% or more of fully advanced cases. The 2010 WHO classification of tumors of
5934-480: The hormone -producing ( endocrine ) tissue of the pancreas have different clinical characteristics and are called pancreatic neuroendocrine tumors , sometimes abbreviated as "PanNETs". Both groups occur mainly (but not exclusively) in people over 40, and are slightly more common in men, but some rare subtypes mainly occur in women or children. The exocrine group is dominated by pancreatic adenocarcinoma (variations of this name may add "invasive" and "ductal"), which
6063-436: The pancreas , a glandular organ behind the stomach , begin to multiply out of control and form a mass . These cancerous cells have the ability to invade other parts of the body. A number of types of pancreatic cancer are known. The most common, pancreatic adenocarcinoma , accounts for about 90% of cases, and the term "pancreatic cancer" is sometimes used to refer only to that type. These adenocarcinomas start within
6192-602: The $ 50 fine. The arrest allegedly occurred "behind a store". Basically Steve Wozniak and I invented the Apple because we wanted a personal computer. Not only couldn't we afford the computers that were on the market, those computers were impractical for us to use. We needed a Volkswagen . The Volkswagen isn't as fast or comfortable as other ways of traveling, but the VW owners can go where they want, when they want and with whom they want. The VW owners have personal control of their car. —Steve Jobs By March 1976, Wozniak completed
6321-512: The Apple II, targeting education, small business, and home markets less vulnerable to IBM. Jobs wanted the company to focus on the closed architecture Macintosh as a business alternative to the IBM PC. President and CEO Sculley had little control over chairman of the board Jobs's Macintosh division; it and the Apple II division operated like separate companies, duplicating services. Although its products provided 85% of Apple's sales in early 1985,
6450-574: The Mac interface." Sculley granted Microsoft the license which later led to problems for Apple. In addition, cheap IBM PC clones that ran Microsoft software and had a graphical user interface began to appear. Although the Macintosh preceded the clones, it was far more expensive, so "through the late 1980s, the Windows user interface was getting better and better and was thus taking increasingly more share from Apple". Windows-based IBM-PC clones also led to
6579-635: The Neem Karoli ashram, it was almost deserted because Neem Karoli Baba had died in September 1973. Then they made a long trek up a dry riverbed to an ashram of Haidakhan Babaji . After seven months, Jobs left India and returned to the US ahead of Daniel Kottke. Jobs had changed his appearance; his head was shaved, and he wore traditional Indian clothing . During this time, Jobs experimented with psychedelics , later calling his LSD experiences "one of
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#17327719838786708-469: The TTL count to 45, far below the usual 100, though Atari later re-engineered it to make it easier to test and add a few missing features. According to Wozniak, Jobs told him that Atari paid them only $ 750 (instead of the actual $ 5,000), and that Wozniak's share was thus $ 375. Wozniak did not learn about the actual bonus until ten years later but said that if Jobs had told him about it and explained that he needed
6837-510: The US. He considered taking up monastic residence at Eihei-ji in Japan , and maintained a lifelong appreciation for Zen, Japanese cuisine, and artists such as Hasui Kawase . Jobs returned to Atari in early 1975, and that summer, Bushnell assigned him to create a circuit board for the arcade video game Breakout in as few chips as possible, knowing that Jobs would recruit Wozniak for help. During his day job at HP, Wozniak drew sketches of
6966-507: The Woodside Town Council's 2009 decision that allowed Jobs to tear down his house. If an appeal was not filed before Jobs obtained a demolition permit, then demolition could proceed. The demolition permit process typically took "the better part of a couple of months", according to Woodside Town Manager Susan George. On April 29, 2010, "Uphold Our Heritage" appealed the March court decision. The appeal put an "automatic stay" on
7095-513: The Year special, released on January 3, 1983, in which she discussed her relationship with Jobs. Rather than name Jobs the Person of the Year, the magazine named the generic personal computer the "Machine of the Year". In the issue, Jobs questioned the reliability of the paternity test, which stated that the "probability of paternity for Jobs, Steven... is 94.1%". He responded by arguing that "28% of
7224-403: The artistic Homestead junior Chrisann Brennan . In 1971, after Wozniak began attending University of California, Berkeley , Jobs would visit him there a few times a week. This experience led him to study in nearby Stanford University 's student union. Instead of joining the electronics club, Jobs put on light shows with a friend for Homestead's avant-garde jazz program. He was described by
7353-506: The basic design of the Apple I computer and showed it to Jobs, who suggested that they sell it; Wozniak was at first skeptical of the idea but later agreed. In April of that same year, Jobs, Wozniak, and administrative overseer Ronald Wayne founded Apple Computer Company (now called "Apple Inc.") as a business partnership in Jobs's parents' Crist Drive home on April 1, 1976. The operation originally started in Jobs's bedroom and later moved to
7482-524: The blue boxes. Jobs later reflected that had it not been for Wozniak's blue boxes, "there wouldn't have been an Apple". He states it showed them that they could take on large companies and beat them. By his senior year of high school, Jobs began using LSD . He later recalled that on one occasion he consumed it in a wheat field outside Sunnyvale, and experienced "the most wonderful feeling of my life up to that point". In mid-1972, after graduation and before leaving for Reed College , Jobs and Brennan rented
7611-408: The body and tail typically also cause pain. People sometimes have recent onset of atypical type 2 diabetes that is difficult to control, a history of recent but unexplained blood vessel inflammation caused by blood clots ( thrombophlebitis ) known as Trousseau sign , or a previous attack of pancreatitis . A doctor may suspect pancreatic cancer when the onset of diabetes in someone over 50 years old
7740-403: The body. Pancreatic cancer rarely occurs before the age of 40, and more than half of cases of pancreatic adenocarcinoma occur in those over 70. Risk factors for pancreatic cancer include tobacco smoking , obesity , diabetes , and certain rare genetic conditions. About 25% of cases are linked to smoking, and 5–10% are linked to inherited genes . Pancreatic cancer is usually diagnosed by
7869-460: The circuit design; at night, he joined Jobs at Atari and continued to refine the design, which Jobs implemented on a breadboard . According to Bushnell, Atari offered $ 100 (equivalent to about $ 600 in 2023) for each TTL chip that was eliminated in the machine. Jobs made a deal with Wozniak to split the fee evenly between them if Wozniak could minimize the number of chips. Much to the amazement of Atari engineers, within four days Wozniak reduced
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#17327719838787998-615: The classic video game Pong and gave its electronics board to Jobs. According to Wozniak, Atari only hired Jobs because he took the board down to the company, and they thought that he had built it himself. Atari's cofounder Nolan Bushnell later described him as "difficult but valuable", pointing out that "he was very often the smartest guy in the room, and he would let people know that". Jobs traveled to India in mid-1974 to visit Neem Karoli Baba at his Kainchi ashram with his Reed College friend and eventual Apple employee Daniel Kottke , searching for spiritual teachings. When they got to
8127-679: The cofounders of Sun Microsystems , said that Jobs broke a " glass age ceiling " in Silicon Valley because he'd created a very successful company at a young age. Markkula brought Apple to the attention of Arthur Rock , which, after looking at the crowded Apple booth at the Home Brew Computer Show, started with a $ 60,000 investment and went on the Apple board. Jobs was not pleased when Markkula recruited Mike Scott from National Semiconductor in February 1977 to serve as
8256-552: The common forms of pancreatic cancer have found that 75% of human genes are expressed in the tumors, with some 200 genes more specifically expressed in pancreatic cancer as compared to other tumor types. Pancreatic ductal adenocarcinoma cancer cells are known to secrete immunosuppressive cytokines, creating to a tumor microenvironment that inhibits immune detection and blocks anti-cancer immunity. Cancer associated fibroblasts secrete fibrous tissue ( desmoplasia ) consisting of matrix metalloproteinases and hyaluronan which blocks
8385-516: The common types of tumor. Four genes have each been found to be mutated in the majority of adenocarcinomas: KRAS (in 95% of cases), CDKN2A (also in 95%), TP53 (75%), and SMAD4 (55%). The last of these is especially associated with a poor prognosis. SWI/SNF mutations/ deletions occur in about 10–15% of the adenocarcinomas. The genetic alterations in several other types of pancreatic cancer and precancerous lesions have also been researched. Transcriptomics analyses and mRNA sequencing for
8514-425: The company's January 1985 annual meeting did not mention the Apple II division or employees. Many left, including Wozniak, who stated that the company had "been going in the wrong direction for the last five years" and sold most of his stock. Though frustrated with the company's and Jobs's dismissal of the Apple II in favor of the Macintosh, Wozniak left amicably and remained an honorary employee of Apple, maintaining
8643-442: The company's acquisition of NeXT. He was largely responsible for reviving Apple, which was on the verge of bankruptcy. He worked closely with British designer Jony Ive to develop a line of products and services that had larger cultural ramifications, beginning with the " Think different " advertising campaign, and leading to the iMac , iTunes , Mac OS X , Apple Store , iPod , iTunes Store , iPhone , App Store , and iPad . Jobs
8772-544: The condition that Jobs must allow the house to be disassembled and moved elsewhere. In February 2010, Magalli and Jason Yoho offered to move the mansion to their five-acre lot in Woodside. Magalli Yoho reported in March that the house resembled a Spanish Colonial Revival mansion she lived in as a child in Ica, Peru. She said, "This house is just a good house for our family." On March 8, 2010, Superior Court Judge Marie Weiner upheld
8901-444: The degree to which they produce hormones. The functioning types secrete hormones such as insulin , gastrin , and glucagon into the bloodstream, often in large quantities, giving rise to serious symptoms such as low blood sugar , but also favoring relatively early detection. The most common functioning PanNETs are insulinomas and gastrinomas , named after the hormones they secrete. The nonfunctioning types do not secrete hormones in
9030-415: The development of additional GUIs such as IBM's TopView or Digital Research's GEM, and thus "the graphical user interface was beginning to be taken for granted, undermining the most apparent advantage of the Mac...it seemed clear as the 1980s wound down that Apple couldn't go it alone indefinitely against the whole IBM-clone market". Pancreatic cancer Pancreatic cancer arises when cells in
9159-430: The development of its unusual case and Rod Holt developed the unique power supply. During the design stage, Jobs argued that the Apple II should have two expansion slots , while Wozniak wanted eight. After a heated argument, Wozniak threatened that Jobs should "go get himself another computer". They later agreed on eight slots. The Apple II became one of the first highly successful mass-produced microcomputer products in
9288-500: The diagnosis and to help decide whether the tumor can be surgically removed (its " resectability "). On contrast CT scan , pancreatic cancer typically shows a gradually increasing radiocontrast uptake, rather than a fast washout as seen in a normal pancreas or a delayed washout as seen in chronic pancreatitis. Magnetic resonance imaging and positron emission tomography may also be used, and magnetic resonance cholangiopancreatography may be useful in some cases. Abdominal ultrasound
9417-436: The digestive system grades all the pancreatic neuroendocrine tumors (PanNETs) into three categories, based on their degree of cellular differentiation (from "NET G1" through to the poorly differentiated "NET G3"). The U.S. National Comprehensive Cancer Network recommends use of the same AJCC-UICC staging system as pancreatic adenocarcinoma. Using this scheme, the stage-by-stage outcomes for PanNETs are dissimilar to those of
9546-424: The disease include weakness and tiring easily, dry mouth , sleep problems, and a palpable abdominal mass . The spread of pancreatic cancer to other organs ( metastasis ) may also cause symptoms. Typically, pancreatic adenocarcinoma first spreads to nearby lymph nodes , and later to the liver or to the peritoneal cavity , large intestine , or lungs. Uncommonly, it spreads to the bones or brain. Cancers in
9675-444: The disease is still in an early stage (AJCC-UICC stages I and II), without spread to large blood vessels or distant organs such as the liver or lungs, surgical resection of the tumor can normally be performed, if the patient is willing to undergo this major operation and is thought to be sufficiently fit. The AJCC-UICC staging system allows distinction between stage III tumors that are judged to be "borderline resectable" (where surgery
9804-422: The disease is typically not diagnosed until it has spread beyond the pancreas itself. This is one of the main reasons for the generally poor survival rates. Exceptions to this are the functioning PanNETs, where over-production of various active hormones can give rise to symptoms (which depend on the type of hormone). Common presenting symptoms of pancreatic adenocarcinoma include: Other common manifestations of
9933-522: The duo gained fame and wealth a year later with production and sale of the Apple II , one of the first highly successful mass-produced microcomputers . Jobs saw the commercial potential of the Xerox Alto in 1979, which was mouse -driven and had a graphical user interface (GUI). This led to the development of the unsuccessful Apple Lisa in 1983, followed by the breakthrough Macintosh in 1984,
10062-437: The established industry of giant mainframe computers with big decks of punch cards: "Steve took me over to the garage. He had a circuit board with a chip on it, a DuMont TV set, a Panasonic cassette tape deck and a keyboard. He said, 'This is an Apple computer.' I said, 'You've got to be joking.' I dismissed the whole idea." Jobs's friend from Reed College and India, Daniel Kottke , recalled that as an early Apple employee, he "was
10191-662: The exocrine cancers. A different TNM system for PanNETs has been proposed by the European Neuroendocrine Tumor Society. Apart from not smoking, the American Cancer Society recommends keeping a healthy weight, and increasing consumption of fruits, vegetables, and whole grains , while decreasing consumption of red and processed meat , although there is no consistent evidence this will prevent or reduce pancreatic cancer specifically. A 2014 review of research concluded that there
10320-461: The expensive Macintosh was hard to sell. In 1985, Bill Gates 's then-developing company, Microsoft , threatened to stop developing Mac applications unless it was granted "a license for the Mac operating system software. Microsoft was developing its graphical user interface ... for DOS, which it was calling Windows and didn't want Apple to sue over the similarities between the Windows GUI and
10449-427: The fact that she realized she was pregnant, and that Jobs was the father. It took her a few days to tell Jobs, whose face, according to Brennan, "turned ugly" at the news. At the same time, according to Brennan, at the beginning of her third trimester, Jobs said to her: "I never wanted to ask that you get an abortion. I just didn't want to do that." He also refused to discuss the pregnancy with her. Brennan turned down
10578-422: The farm owner. While distant, Jobs worked with her on a name for the baby, which they discussed while sitting in the fields on a blanket. Brennan suggested the name "Lisa" which Jobs also liked and notes that Jobs was very attached to the name "Lisa" while he "was also publicly denying paternity". She would discover later that during this time, Jobs was preparing to unveil a new kind of computer that he wanted to give
10707-579: The first batch, Wozniak sold his HP scientific calculator and Jobs sold his Volkswagen van . Later that year, computer retailer Paul Terrell purchased 50 fully assembled Apple I units for $ 500 each. Eventually about 200 Apple I computers were produced in total. A neighbor on Crist Drive recalled Jobs as an odd individual who would greet his clients "with his underwear hanging out, barefoot and hippie-like". Another neighbor, Larry Waterland, who had just earned his PhD in chemical engineering at Stanford, recalled dismissing Jobs's budding business compared to
10836-586: The first mass-produced computer with a GUI. The Macintosh launched the desktop publishing industry in 1985 (for example, the Aldus Pagemaker ) with the addition of the Apple LaserWriter , the first laser printer to feature vector graphics and PostScript . In 1985, Jobs departed Apple after a long power struggle with the company's board and its then-CEO, John Sculley . That same year, Jobs took some Apple employees with him to found NeXT,
10965-403: The first president and CEO of Apple. For what characterizes Apple is that its scientific staff always acted and performed like artists – in a field filled with dry personalities limited by the rational and binary worlds they inhabit, Apple's engineering teams had passion. They always believed that what they were doing was important and, most of all, fun. Working at Apple was never just a job; it
11094-565: The garage. Wayne stayed briefly, leaving Jobs and Wozniak as the active primary cofounders of the company. The two decided on the name "Apple" after Jobs returned from the All One Farm commune in Oregon and told Wozniak about his time in the farm's apple orchard . Jobs originally planned to produce bare printed circuit boards of the Apple I and sell them to computer hobbyists for $ 50 (equivalent to about $ 270 in 2023) each. To fund
11223-569: The host's CD8+ T-cells from reaching the tumor. Tumor associated macrophages , neutrophils and regulatory T-cells secrete cytokines and work to create a tumor microenvironment that promotes cancer growth. The genes often found mutated in pancreatic neuroendocrine tumors (PanNETs) are different from those in exocrine pancreatic cancer. For example, KRAS mutation is normally absent. Instead, hereditary MEN1 gene mutations give risk to MEN1 syndrome , in which primary tumors occur in two or more endocrine glands . About 40–70% of people born with
11352-680: The house down. Jobs appealed to the State Court of Appeals, and in January 2007, that Court unanimously confirmed the lower court ruling. Jobs' attorney asked for an appeal but in April 2007, the Supreme Court of California refused to hear it. In 2008, Jobs submitted a renewed permit application with updated estimates. The Woodside Town Council granted the permit a year later, in May 2009, with
11481-417: The internship and decided to leave Apple. A few weeks before she was due to give birth, Brennan was invited to deliver her baby at the All One Farm. She accepted the offer. When Jobs was 23 (the same age as his biological parents when they had him) Brennan gave birth to her baby, Lisa Brennan , on May 17, 1978. Jobs went there for the birth after he was contacted by Robert Friedland , their mutual friend and
11610-434: The issuance of demolition permits. The group hoped that the house could be relocated and restored. Later in 2010, Judge Weiner upheld the council's decision to allow the house to be demolished. The pipe organ was removed in January 2011, and the entire residence was demolished the next month. Nothing was built on the site, and Jobs died later that year on October 5, 2011, of pancreatic cancer . Laurene Powell Jobs proposed
11739-489: The local Hare Krishna temple. In that same speech, Jobs said: "If I had never dropped in on that single calligraphy course in college, the Mac would have never had multiple typefaces or proportionally spaced fonts". I was lucky to get into computers when it was a very young and idealistic industry. There weren't many degrees offered in computer science, so people in computers were brilliant people from mathematics, physics, music, zoology, whatever. They loved it, and no one
11868-405: The male population of the United States could be the father". Time also noted that "the baby girl and the machine on which Apple has placed so much hope for the future share the same name: Lisa". In 1978, at age 23, Jobs was worth over $ 1 million (equivalent to $ 4.67 million in 2023). By age 25, his net worth grew to an estimated $ 250 million (equivalent to $ 838 million in 2023). He
11997-829: The money, Wozniak would have given it to him. Jobs and Wozniak attended meetings of the Homebrew Computer Club in 1975, which was a stepping stone to the development and marketing of the first Apple computer. According to a document released by the United States Department of Defense , Jobs claimed that in 1975, he was arrested in Eugene, Oregon , after being questioned for being a minor in possession of alcohol. Jobs alleged that he "didn't have any alcohol", but police questioned him, and subsequently determined that he had an outstanding arrest warrant for an unpaid speeding ticket. Jobs claimed he then paid
12126-471: The most-common form of pancreatic cancer may include yellow skin , abdominal or back pain , unexplained weight loss , light-colored stools , dark urine, and loss of appetite . Usually, no symptoms are seen in the disease's early stages, and symptoms that are specific enough to suggest pancreatic cancer typically do not develop until the disease has reached an advanced stage. By the time of diagnosis, pancreatic cancer has often spread to other parts of
12255-420: The new cases in 2012 originated. Pancreatic adenocarcinoma typically has a very poor prognosis; after diagnosis, 25% of people survive one year and 12% live for five years. For cancers diagnosed early, the five-year survival rate rises to about 20%. Neuroendocrine cancers have better outcomes; at five years from diagnosis, 65% of those diagnosed are living, though survival considerably varies depending on
12384-448: The only person who worked in the garage ... Woz would show up once a week with his latest code. Steve Jobs didn't get his hands dirty in that sense." Kottke also stated that much of the early work took place in Jobs's kitchen, where he spent hours on the phone trying to find investors for the company. They received funding from a then-semi-retired Intel product marketing manager and engineer named Mike Markkula . Scott McNealy , one of
12513-523: The organ, are in his collected papers in the Stanford University Library . After Jackling's wife Virginia died in 1957, the home was sold in 1958 and its surrounding land – nearly 194 acres (79 ha) – was subdivided. The house had three other owners before its last one bought the property, which had a list price of $ 3.5 million, in 1984. In 1984 Steve Jobs purchased the Jackling House and estate, and resided there for
12642-494: The pancreas are mainly pancreatic neuroendocrine tumors (PanNETs). Neuroendocrine tumors (NETs) are a diverse group of benign or malignant tumors that arise from the body's neuroendocrine cells , which are responsible for integrating the nervous and endocrine systems. NETs can start in most organs of the body, including the pancreas, where the various malignant types are all considered to be rare . PanNETs are grouped into 'functioning' and 'nonfunctioning' types, depending on
12771-403: The pancreas may also be secondary cancers that have spread from other parts of the body. This is uncommon, found in only about 2% of cases of pancreatic cancer. Kidney cancer is by far the most common cancer to spread to the pancreas, followed by colorectal cancer , and then cancers of the skin , breast , and lung . Surgery may be performed on the pancreas in such cases, whether in hope of
12900-684: The pancreas. This cancer originates in the ducts that carry secretions (such as enzymes and bicarbonate ) away from the pancreas. About 60–70% of adenocarcinomas occur in the head of the pancreas . The next-most common type, acinar cell carcinoma of the pancreas , arises in the clusters of cells that produce these enzymes, and represents 5% of exocrine pancreas cancers. Like the 'functioning' endocrine cancers described below, acinar cell carcinomas may cause over-production of certain molecules, in this case digestive enzymes, which may cause symptoms such as skin rashes and joint pain. Cystadenocarcinomas account for 1% of pancreatic cancers, and they have
13029-422: The part of the pancreas that makes digestive enzymes . Several other types of cancer, which collectively represent the majority of the non-adenocarcinomas, can also arise from these cells. About 1–2% of cases of pancreatic cancer are neuroendocrine tumors , which arise from the hormone-producing cells of the pancreas. These are generally less aggressive than pancreatic adenocarcinoma. Signs and symptoms of
13158-541: The project. On January 22, 1984, Apple aired a Super Bowl television commercial titled " 1984 ", which ended with the words: "On January 24th, Apple Computer will introduce Macintosh. And you'll see why 1984 won't be like 1984 ." On January 24, 1984, an emotional Jobs introduced the Macintosh to a wildly enthusiastic audience at Apple's annual shareholders meeting held in the Flint Auditorium at De Anza College. Macintosh engineer Andy Hertzfeld described
13287-567: The public, as required by state law", the group's attorney Doug Carstens said. "The issue before you is not to preserve and rehabilitate a work of marginal importance; it is to assure the protection and survival of a work of great significance", said the California Department of Parks and Recreation's State Historical Resources Commission chairperson Anthea Hartig, PhD. In January 2006, Superior Court Judge Marie Weiner agreed with "Uphold Our Heritage" and held that Jobs could not tear
13416-455: The relationship. In October 1977, Brennan was approached by Rod Holt , who asked her to take "a paid apprenticeship designing blueprints for the Apples". Both Holt and Jobs believed that it would be a good position for her, given her artistic abilities. Holt was particularly eager that she take the position and puzzled by her ambivalence toward it. Brennan's decision, however, was overshadowed by
13545-465: The rest of your life selling sugared water, or do you want a chance to change the world?". In 1984, Jobs bought the Jackling House and estate and resided there for a decade. Thereafter, he leased it out for several years until 2000 when he stopped maintaining the house, allowing weathering to degrade it. In 2004, Jobs received permission from the town of Woodside to demolish the house to build
13674-527: The scene as "pandemonium". The Macintosh was inspired by the Lisa (in turn inspired by Xerox PARC's mouse -driven graphical user interface ), and it was widely acclaimed by the media with strong initial sales. However, its low performance and limited range of available software led to a rapid sales decline in the second half of 1984. Sculley's and Jobs's respective visions for the company greatly differed. Sculley favored open architecture computers like
13803-410: The school for not challenging his brilliant son. Jobs skipped the 5th grade and transferred to the 6th grade at Crittenden Middle School in Mountain View, where he became a "socially awkward loner". Jobs was often "bullied" at Crittenden Middle, and in the middle of 7th grade, he gave his parents an ultimatum: either they would take him out of Crittenden or he would drop out of school. The Jobs family
13932-471: The shores about then. At Reed there was a constant flow of people stopping by – from Timothy Leary and Richard Alpert , to Gary Snyder . There was a constant flow of intellectual questioning about the truth of life. That was the time when every college student in the country read Be Here Now and Diet for a Small Planet . —Steve Jobs After just one semester, Jobs dropped out of Reed College without telling his parents. Jobs later explained this
14061-458: The thick head, the neck, and the tapering body, ending in the tail. Regardless of a tumor's location, the most common symptom is unexplained weight loss, which may be considerable. A large minority (between 35% and 47%) of people diagnosed with the disease will have had nausea, vomiting, or a feeling of weakness. Tumors in the head of the pancreas typically also cause jaundice, pain, loss of appetite , dark urine, and light-colored stools. Tumors in
14190-451: The town and Jobs, claiming that both had ignored provisions of California law which prohibit cultural landmarks from being destroyed if there are reasonable, feasible ways to preserve them. They also contended that the initial environmental impact report did not demonstrate that preserving the house would cost more than replacing it. "In addition, the town failed to demonstrate that demolishing the mansion would provide an 'overriding benefit' to
14319-674: The two or three most important things [he had] done in [his] life". He spent a period at the All One Farm , a commune in Oregon that was owned by Robert Friedland . During this time period, Jobs and Brennan both became practitioners of Zen Buddhism through the Zen master Kōbun Chino Otogawa . Jobs engaged in lengthy meditation retreats at the Tassajara Zen Mountain Center , the oldest Sōtō Zen monastery in
14448-404: The type of tumor. The many types of pancreatic cancer can be divided into two general groups. The vast majority of cases (about 95%) occur in the part of the pancreas that produces digestive enzymes , known as the exocrine component . Several subtypes of exocrine pancreatic cancers are described, but their diagnosis and treatment have much in common. The small minority of cancers that arise in
14577-521: The world. As Jobs became more successful with his new company, his relationship with Brennan grew more complex. In 1977, the success of Apple was now a part of their relationship, and Brennan, Daniel Kottke , and Jobs moved into a house near the Apple office in Cupertino . Brennan eventually took a position in the shipping department at Apple. Brennan's relationship with Jobs deteriorated as his position with Apple grew, and she began to consider ending
14706-562: Was 13, in 1968, Jobs was given a summer job by Bill Hewlett (of Hewlett-Packard ) after Jobs cold-called him to ask for parts for an electronics project. The location of the Los Altos home meant that Jobs would be able to attend nearby Homestead High School , which had strong ties to Silicon Valley . He began his first year there in late 1968 along with Bill Fernandez , who introduced Jobs to Steve Wozniak, and would become Apple's first employee. Neither Jobs nor Fernandez (whose father
14835-468: Was a lawyer) came from engineering households and thus decided to enroll in John McCollum's Electronics I class. Jobs had grown his hair long and become involved in the growing counterculture, and the rebellious youth eventually clashed with McCollum and lost interest in the class. Jobs underwent a change during mid-1970. He later noted to his official biographer that "I started to listen to music
14964-406: Was already aware, and later said that he had been deeply loved and indulged by Paul and Clara. Jobs would "bristle" when Paul and Clara were referred to as his "adoptive parents", and he regarded them as his parents "1,000%". Jobs referred to his biological parents as "my sperm and egg bank. That's not harsh, it's just the way it was, a sperm bank thing, nothing more." I always thought of myself as
15093-658: Was also a board member at Gap Inc. from 1999 to 2002. In 2003, Jobs was diagnosed with a pancreatic neuroendocrine tumor . He died of tumor-related respiratory arrest in 2011; in 2022, he was posthumously awarded the Presidential Medal of Freedom . Since his death, he has won 141 patents; Jobs holds over 450 patents in total. Steven Paul Jobs was born in San Francisco, California, on February 24, 1955, to Joanne Carole Schieble and Abdulfattah "John" Jandali ( Arabic : عبد الفتاح الجندلي ). Abdulfattah Jandali
15222-492: Was also a crusade, a mission, to bring better computer power to people. At its roots, that attitude came from Steve Jobs. It was " Power to the People ", the slogan of the sixties, rewritten in technology for the eighties and called Macintosh . —Jeffrey S. Young, 1987 After Brennan returned from her own journey to India, she and Jobs fell in love again, as Brennan noted changes in him that she attributes to Kobun (whom she
15351-567: Was also one of the youngest "people ever to make the Forbes list of the nation's richest people—and one of only a handful to have done it themselves, without inherited wealth". In 1982, Jobs bought an apartment on the top two floors of The San Remo , a Manhattan building with a politically progressive reputation. Although he never lived there, he spent years renovating it thanks to I. M. Pei . In 1983, Jobs lured John Sculley away from Pepsi-Cola to serve as Apple's CEO, asking, "Do you want to spend
15480-550: Was also still following). It was also at this time that Jobs displayed a prototype Apple II computer for Brennan and his parents in their living room. Brennan notes a shift in this time period, where the two main influences on Jobs were Apple Inc. and Kobun . In April 1977, Jobs and Wozniak introduced the Apple II at the West Coast Computer Faire . It is the first consumer product to have been sold by Apple Computer. Primarily designed by Wozniak, Jobs oversaw
15609-720: Was an American businessman, inventor, and investor best known for co-founding the technology company Apple Inc. Jobs was also the founder of NeXT and chairman and majority shareholder of Pixar . He was a pioneer of the personal computer revolution of the 1970s and 1980s, along with his early business partner and fellow Apple co-founder Steve Wozniak . Jobs was born in San Francisco in 1955 and adopted shortly afterwards. He attended Reed College in 1972 before withdrawing that same year. In 1974, he traveled through India, seeking enlightenment before later studying Zen Buddhism . He and Wozniak co-founded Apple in 1976 to further develop and sell Wozniak's Apple I personal computer. Together,
15738-400: Was an individual, in a world where individuality was suspect." By his senior year in late 1971, he was taking a freshman English class at Stanford and working on a Homestead underground film project with Chrisann Brennan. Around that time, Wozniak designed a low-cost digital " blue box " to generate the necessary tones to manipulate the telephone network, allowing free long-distance calls. He
15867-435: Was because he did not want to spend his parents' money on an education that seemed meaningless to him. He continued to attend by auditing his classes, including a course on calligraphy that was taught by Robert Palladino . In a 2005 commencement speech at Stanford University , Jobs stated that during this period, he slept on the floor in friends' dorm rooms, returned Coke bottles for food money, and got weekly free meals at
15996-662: Was born in a Muslim household to wealthy Syrian parents, the youngest of nine siblings. After obtaining his undergraduate degree at the American University of Beirut , Jandali pursued a PhD in political science at the University of Wisconsin . There, he met Joanne Schieble, an American Catholic of Swiss-German descent whose parents owned a mink farm and real estate in Green Bay . The two fell in love but faced opposition from Schieble's father due to Jandali's Muslim faith. When Schieble became pregnant, she arranged for
16125-494: Was evidence that consumption of citrus fruits and curcumin reduced risk of pancreatic cancer, while there was possibly a beneficial effect from whole grains, folate , selenium , and non-fried fish. In the general population, screening of large groups is not considered effective and may be harmful as of 2019, although newer techniques, and the screening of tightly targeted groups, are being evaluated. Nevertheless, regular screening with endoscopic ultrasound and MRI/CT imaging
16254-538: Was inspired by an article titled "Secrets of the Little Blue Box" from the October 1971 issue of Esquire . Jobs decided then to sell them and split the profit with Wozniak. The clandestine sales of the illegal blue boxes went well and perhaps planted the seed in Jobs's mind that electronics could be both fun and profitable. In a 1994 interview, he recalled that it took six months for him and Wozniak to design
16383-490: Was named for my daughter". When Jobs denied paternity, a DNA test established him as Lisa's father. It required him to pay Brennan $ 385 (equivalent to about $ 1,200 in 2023) monthly in addition to returning the welfare money she had received. Jobs paid her $ 500 (equivalent to about $ 1,500 in 2023) monthly at the time when Apple went public and made him a millionaire. Later, Brennan agreed to interview with Michael Moritz for Time magazine for its Time Person of
16512-531: Was not affluent, and only by expending all their savings were they able to buy a new home in 1967, allowing Steve to change schools. The new house (a three-bedroom home on Crist Drive in Los Altos, California ) was in the better Cupertino School District , in Cupertino, California . The house was declared a historic site in 2013, as the first site of Apple Computer. As of 2013 , it was owned by Jobs's sister, Patty, and occupied by his stepmother, Marilyn. When he
16641-491: Was really in it for the money [...] There are people around here who start companies just to make money, but the great companies, well, that's not what they're about. —Steve Jobs In February 1974, Jobs returned to his parents' home in Los Altos and began looking for a job. He was soon hired by Atari, Inc. in Los Gatos, California , as a computer technician . Back in 1973, Steve Wozniak designed his own version of
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