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88-410: The song begins with lead singer Rob Thomas drawing a breath before singing the first verse, joined by an acoustic guitar; the second half of the verse goes to electric guitar for the remainder of the song. The first half of the second pre-chorus has acoustic guitar again before the electric guitar comes back as the pre-chorus concludes. The video for "Long Day" (directed by Roger Pistole), like most of

176-404: A GED . He was convicted of stealing a Camaro and spent two months in county jail when he was 17. For the next two or three years, Thomas was homeless. Occasionally he'd stay for a few days or weeks at the homes of various friends. At other times, he would hitchhike around Florida and South Carolina. Soon after getting out of jail, Thomas connected with several local musicians. He played in

264-527: A United States Army sergeant, and Mamie. Thomas has an elder half sister, Melissa, from his mother's previous marriage. The family returned to the United States when Thomas was six months old. His parents divorced when he was two years old. Thomas lived with his mother and sister. They were poor and moved frequently, often staying with Mamie's mother in Lake City, South Carolina . His grandmother

352-425: A bimodal curve for the number of cases; that is, it occurs most frequently in two separate age groups, the first being young adulthood (age 15–35) and the second being in those over 55 years old although these peaks may vary slightly with nationality. Overall, it is more common in males, except for the nodular sclerosis variant, which is slightly more common in females. The annual number of cases of Hodgkin lymphoma

440-402: A gallium scan may be used instead of a PET scan. The two main types of Hodgkin lymphoma are classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. The prevalence of classic Hodgkin lymphoma and nodular-lymphocyte Hodgkin lymphoma are about 90 and 10%, respectively. The morphology, phenotype, molecular features, and, therefore, the clinical behaviour and presentation of

528-705: A Heart Breaks ", went gold in the US and hit the top 50 in Australia. The third single, " Ever the Same ", became a top five Adult Contemporary hit. On October 5, 2005, he started his first solo tour, the Something to Be Tour . In the summer of 2006, Thomas toured with Jewel and Toby Lightman . In September 2006, Thomas's solo effort received more exposure when ABC started using the song " Streetcorner Symphony " in promotional ads for its popular Thursday night lineup. This song

616-454: A Hodgkin's lymphoma on the progression-free survival. Negative interim PET scan results may result in an increase in progression-free survival compared if the adjusted result was measured. Negative interim PET scan results probably result in a large increase in the overall survival compared to those with a positive interim PET scan result, Unlike some other lymphomas , whose number of new cases per year increases with age, Hodgkin lymphoma has

704-573: A credited songwriter for other artists including Willie Nelson , Mick Jagger , Marc Anthony , Pat Green , Taylor Hicks , Travis Tritt , and Daughtry . In 2004, the Songwriters Hall of Fame awarded Thomas its first Hal David Starlight Award which recognizes young songwriters who've quickly gained a lasting influence in the music industry. Thomas was born in Landstuhl , Germany , at Landstuhl Regional Medical Center to Bill Thomas,

792-407: A few different ways radiation oncologists target the cancer cells. Involved site radiation is when the radiation oncologists give radiation only to those parts of the person's body known to have the cancer. Very often, this is combined with chemotherapy. Radiation therapy directed above the diaphragm to the neck, chest or underarms is called mantle field radiation . Radiation to below the diaphragm to

880-458: A major concern, mainly gonadal dysfunction and growth retardation . Gonadal dysfunction seems to be the most severe endocrine long-term effect, especially after treatment with alkylating agents or pelvic radiotherapy. It is possible that patients undergoing a chemotherapy need a platelet transfusion. If a stem cell transplantation is necessary for the treatment of a relapse, graft-versus-host diseases might occur. Adding physical exercises to

968-486: A negative PET versus only 28% in those with positive PET scans. This prognostic method improves on FFP estimates based on the seven conventional factors. Several trials are underway to see if PET-based risk adapted response can be used to improve a person's outcomes by changing chemotherapy early in people who are not responding. The evidence is very uncertain about the effect of negative (= good prognosis) or positive (= bad prognosis) interim PET scan results for patients with

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1056-611: A nodular aspect may appear. A fibrin ring granuloma may be seen. Microscopic examination of the lymph node biopsy reveals complete or partial effacement of the lymph node architecture by scattered large malignant cells known as Reed-Sternberg cells (RSC) (typical and variants) admixed within a reactive cell infiltrate composed of variable proportions of lymphocytes, histiocytes, eosinophils, and plasma cells. The Reed–Sternberg cells are identified as large often bi-nucleated cells with prominent nucleoli and an unusual CD45 −, CD30 +, CD15 +/− immunophenotype. In approximately 50% of cases,

1144-504: A recording contract. Thomas, Yale, and Doucette were still interested in working together, and Serletic introduced them to rhythm guitarist Adam Gaynor and lead guitarist Kyle Cook ; together, they formed a new band, Matchbox 20 . Serletic sent Thomas to vocal coach Jan Smith to learn how to refine his vocal power. The band recorded several demo tapes, with Serletic as their producer. Three radio stations in Orlando and Tampa added

1232-741: A series of cover bands and began writing songs in earnest. Thomas said that "in songwriting I felt special for the first time. And all I wanted to do was get out of Florida." One of his bands, Fair Warning, earned a three-week job playing at a hotel in Vero Beach . They were fired three days into the job, after they were caught stealing beer and candy from the hotel. He was, at one point, a member of another band, Tidal Wave, which played mostly surf tunes. Thomas used drugs, and during one acid trip , he decided to play with dry ice . His hands were burned so badly that doctors initially thought they would require amputation. Thomas' sister recalled that while she

1320-461: A solo artist, Thomas is known for "emotive radio hits". His solo albums have a much stronger pop feel. His album, The Great Unknown , was "unabashed pop". His detractors say the music is fluff and too sweet. Hodgkins lymphoma Hodgkin lymphoma ( HL ) is a type of lymphoma in which cancer originates from a specific type of white blood cell called lymphocytes , where multinucleated Reed–Sternberg cells (RS cells) are present in

1408-500: A songwriter. BMI named Thomas its 1999 Pop Songwriter of the Year for "Smooth" and his Matchbox 20 songs. "Smooth" would ultimately become the second biggest-selling single of all time, after Chubby Checker's "The Twist." "Smooth" increased his visibility, and that of Matchbox 20. The song's video, starring Thomas, was played extensively on VH1 and MTV . That exposure launched him out of anonymity. A new set of listeners, older than

1496-586: A substantial amount of credibility." Thomas says that "Smooth" "really opened up the door for me as a songwriter and a solo artist." As Matchbox 20 prepared to record their second album, band members had heated discussions over song selection. After flirting with the idea of allowing other band members to provide songs, they chose to record only songs that Thomas had written or co-written. They renamed themselves Matchbox Twenty and, in March 2000, released Mad Season . Its first single, " Bent ", reached number 1 on

1584-566: A successor to Hodgkin at Guy's Hospital, was unaware of Hodgkin's prior work on the subject. Bright informed Wilks of Hodgkin's contribution and in 1865, Wilks published a second paper, entitled "Cases of enlargement of the lymphatic glands and spleen", in which he named the illness "Hodgkin's disease" in honor of his predecessor. Theodor Langhans and WS Greenfield first described the microscopic characteristics of Hodgkin lymphoma in 1872 and 1878, respectively. In 1898 and 1902, respectively, Carl Sternberg and Dorothy Reed independently described

1672-399: Is 2.7 per 100,000 per persons per year, and the disease accounts for slightly less than 1% of all cancers worldwide. In 2010, globally it resulted in about 18,000 deaths down from 19,000 in 1990. In 2012, there were an estimated 65,950 cases and 25,469 deaths from Hodgkin lymphoma worldwide, with 28,852 and 37,098 cases occurring in developed and developing countries, respectively. However,

1760-422: Is 42%. The adverse prognostic factors identified in the international study are: Other studies have reported the following to be the most important adverse prognostic factors: mixed-cellularity or lymphocyte-depleted histologies, male sex, large number of involved nodal sites, advanced stage, age of 40 years or more, the presence of B symptoms, high erythrocyte sedimentation rate , and bulky disease (widening of

1848-405: Is another subtype of Hodgkin lymphoma distinct from classic Hodgkin lymphoma and is characterized by the presence of popcorn cells which express CD20 . Due to these differences, among others, NLPHL is often treated differently from classic Hodgkin lymphoma, including using rituximab in combination with AVBD chemotherapy, though individual cases vary and clinical trials are ongoing. The staging

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1936-418: Is by lymph node biopsy (usually excisional biopsy with microscopic examination). Blood tests are also performed to assess function of major organs and safety for chemotherapy. Positron emission tomography (PET) is used to detect small deposits that do not show on CT scanning. PET scans are also useful in functional imaging (by using a radiolabeled glucose to image tissues of high metabolism). In some cases,

2024-412: Is most commonly found in the subtypes lymphocyte depleted HL (>70%) and mixed cellularity HL (70%), whilst being less prevalent in lymphocyte-rich HL (40%) and relatively uncommon by comparison in nodular sclerosing HL. For the other forms, although the traditional B-cell markers (such as CD20 ) are not expressed on all cells, Reed–Sternberg cells are usually of B cell origin. Although Hodgkin's

2112-525: Is not as important as it is in non-Hodgkin lymphoma : the treatment and prognosis in classic Hodgkin lymphoma usually depends on the stage of disease rather than the histotype. The current approach for treatment aims to reduce the acute and long-term toxicities associated with Hodgkin lymphoma (e.g. cardiac damage and secondary cancers) and increase overall survival. People with early stage disease (IA or IIA) can be treated effectively with radiation therapy or chemotherapy. The choice of treatment depends on

2200-532: Is now frequently grouped with other B-cell malignancies, some T-cell markers (such as CD2 and CD4 ) are occasionally expressed. However, this may be an artifact of the ambiguity inherent in the diagnosis. Hodgkin cells produce interleukin-21 (IL-21), which was once thought to be exclusive to T-cells. This feature may explain the behavior of classic Hodgkin lymphoma, including clusters of other immune cells gathered around HL cells (infiltrate) in cultures. Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL)

2288-561: Is the lead vocalist for the Florida-based alternative rock band Matchbox Twenty , which he formed in 1995 and with whom he has released five studio albums. As a solo act, he is best known for his guest performance on Santana 's 1999 single " Smooth ", which won three Grammy Awards , peaked the Billboard Hot 100 and in 2018, was named the second most successful song in the chart's history. His 2005 single, " Lonely No More "

2376-477: Is the same for both Hodgkin and non-Hodgkin lymphomas. After Hodgkin lymphoma is diagnosed, a person will be staged : that is, they will undergo a series of tests and procedures that will determine what areas of the body are affected. These procedures may include documentation of their histology , a physical examination, blood tests, chest X-ray radiographs, computed tomography (CT)/ positron emission tomography (PET)/ magnetic resonance imaging (MRI) scans of

2464-511: The Orlando area the following year. Around this time, Thomas received his first musical instrument, a Casio keyboard. A friend taught him to play, and Thomas practiced by trying to reproduce the songs he heard on the radio. He also acquired a guitar with no strings, which he used as a prop while he pretended he was in a rock band. His home life was not stable. Thomas describes his mother as an alcoholic who occasionally beat him. When Thomas

2552-509: The Songwriters Hall of Fame gave Thomas the inaugural Hal David Starlight Award, which recognizes a young songwriter who has made an outsized impression on the industry. On April 19, 2005, Thomas began his solo career with the release of ...Something to Be which debuted at number 1 on the Billboard 200 album chart. The album included several songs that the other Matchbox Twenty members had rejected, such as "I Am An Illusion". The album

2640-579: The mediastinum by more than one third, or the presence of a nodal mass measuring more than 10 cm in any dimension.) More recently, the use of positron emission tomography (PET) early after commencing chemotherapy has demonstrated to have powerful prognostic ability. This enables assessment of an individual's response to chemotherapy as the PET activity switches off rapidly in people who are responding. In this study, after two cycles of ABVD chemotherapy, 83% of people were free of disease at 3 years if they had

2728-616: The Billboard Hot 100 chart; it remains the band's only number one hit, despite larger commercial success on previous material. Their tour took them to 87 cities, and they sold out Madison Square Garden in 15 minutes. Thomas was inducted into the South Carolina Music and Entertainment Hall of Fame in 2001. When Santana prepared to record his follow-up to Supernatural , he sought to collaborate with Thomas again. Instead of providing vocals, Thomas wrote two songs for

Long Day - Misplaced Pages Continue

2816-523: The CT scan and PET scan. On the basis of this staging, the person will be classified according to a staging classification (the Ann Arbor staging classification scheme is a common one): The absence of systemic symptoms is signified by adding "A" to the stage; the presence of systemic symptoms is signified by adding "B" to the stage. For localised extranodal extension from mass of nodes that does not advance

2904-556: The Orlando area, where they played in bars and nightclubs. Most of their songs were written by Thomas, including " 3 A.M. " This song, inspired by his time taking care of his mother, was the first that he had ever written and liked. In an effort to recreate that magic, his writing shifted to focus more on emotions inspired from his own life. Producer Matt Serletic heard them play and was intrigued. The band met him for an introductory meeting, but broke up before any contracts were signed. Thomas worried that he'd never get another chance for

2992-445: The Orlando suburb of Altamonte Springs . Thomas joined the choir in an unsuccessful attempt to attract the attention of a girl that he liked. His choir teacher told him to keep working, because he saw potential in him. To impress girls at parties, Thomas wrote and played music. A few months before graduation, Thomas dropped out of high school, saying his "regular life was in such disarray that going seemed ridiculous". He later earned

3080-740: The Reed–Sternberg cells are infected by the Epstein–Barr virus. Characteristics of classic Reed–Sternberg cells include large size (20–50 micrometres), abundant, amphophilic, finely granular/homogeneous cytoplasm; two mirror-image nuclei (owl eyes) each with an eosinophilic nucleolus and a thick nuclear membrane ( chromatin is distributed close to the nuclear membrane). Almost all of these cells have an increased copy number of chromosome 9p/9p24.1. Variants: Hodgkin lymphoma can be sub-classified by histological type. The cell histology in Hodgkin lymphoma

3168-524: The Saints , and that kinda carried us a long way through. It gave us a whole new bed to work with, like 'How do I get my pop sensibility around this and work it into that?' It was a lot of fun. But you go through different phases when you're writing; it took a different turn, and I just followed it, too. On March 2, 2009, Clark Collis of Entertainment Weekly interviewed Thomas, where he confirmed he had since shelved his initial efforts to evoke The Rhythm of

3256-526: The Saints , and claimed the album was scheduled for a June 30 release. Having played half the forthcoming album to Entertainment Weekly , it was reported that many of the lyrics on Cradlesong were about troubled relationships, and three more song titles were revealed: "Meltdown" (described as " INXS -esque power pop" that stood out as "a possible first single"), "Fire on the Mountain" (an "epic, tribal drum-driven" track inspired by Dave Eggers ' book What Is

3344-469: The What ) and "Getting Late" (suggested as the "set's likely closer" and what Thomas described as "a little ditty about death."). On March 11, 2009, Rob Thomas created his own Twitter account and announced via the social application that " Her Diamonds " would be the lead single from Cradlesong . Thomas has also stated via Twitter that Cradlesong had been mastered and featured fourteen tracks culled from

3432-468: The abdomen, spleen or pelvis is called inverted-Y field radiation. Total nodal irradiation is when the therapist gives radiation to all the lymph nodes in the body to destroy cells that may have spread. The high cure rates and long survival of many people with Hodgkin lymphoma has led to a high concern with late adverse effects of treatment, including cardiovascular disease and second malignancies such as acute leukemias , lymphomas, and solid tumors within

3520-463: The age, sex, bulk and the histological subtype of the disease. Adding localised radiation therapy after the chemotherapy regimen may provide a longer progression-free survival compared with chemotherapy treatment alone. People with later disease (III, IVA, or IVB) are treated with combination chemotherapy alone. People of any stage with a large mass in the chest are usually treated with combined chemotherapy and radiation therapy. Although no longer

3608-604: The age-standardized rates were higher in developed regions, with the greatest rates in the Americas (1.5 per 100,000), East Mediterranean Region (1.5 per 100,000), and Europe (2.0 per 100,000). The East Mediterranean Region also has the highest age-standardized mortality rate of 1.0 per 100,000, which is mainly attributed to lifestyle and environmental risk factors associated with transitional economies such as smoking, obesity, physical inactivity, and reproductive behaviors, as well as availability of diagnostic practices and awareness of

Long Day - Misplaced Pages Continue

3696-423: The album as "the usual mish-mosh of styles, but hopefully just holding true to a bunch of good songs." The article also mentioned that the record would nonetheless feature several tracks that "take a more global, rhythmic direction after working with South American and African percussionists." Thomas explained one such experiment: We started off with the idea of doing a newer version of (Paul Simon's) The Rhythm of

3784-573: The album with his 2009/2010 tour, Cradlesong Tour . In March 2010, Thomas announced plans to release a four-song digital-only EP entitled the Someday EP . Featuring three new songs, the EP was released to iTunes on March 30, 2010, and all other digital retailers April 6, 2010. After his solo success, many of Thomas's confidants urged him to leave Matchbox Twenty. As Thomas wrapped up his tour for Cradlesong , he began writing songs for consideration for

3872-501: The album, which were recorded by Seal and Musiq . Thomas provided songs to other artists as well. Willie Nelson recorded three of Thomas's songs on his 2002 album The Great Divide . One of those, "Recollection Phoenix", had been in contention for the next Matchbox Twenty album before the other band members had decided it wasn't a good fit. The third Matchbox Twenty album, More Than You Think You Are , wasn't complete until four weeks before its release date, November 19, 2002. For

3960-734: The album, which will include both original and cover songs, in his home studio in New York during the summer. Matchbox Twenty got back together for " Where the Light Goes " album in May 2023, which is being toured in 2024 After spending more than 20 years as part of Matchbox Twenty and more than 10 years working on solo material, Thomas has become adept at navigating the "identity crisis" of two separate musical worlds. Although he does play some Matchbox Twenty songs during his solo tours, they are always reimagined, often as an acoustic version. As

4048-546: The band's initial fan base, was exposed to, and liked, Thomas's work. Yourself or Someone Like You continued to sell briskly. After winning at the Grammy Awards, Atlantic took out ads in many industry publications to make executives aware that Thomas had written not only "Smooth", but also all of the songs on the Matchbox 20 album. Ron Shapiro, an executive at Atlantic, said, "It was our intent to get Rob and this band

4136-410: The band's material centers around Matchbox Twenty, but is punctuated by black and white shots from an old movie. Thomas has shorter hair than in the subsequent clips and is dressed in a suit and sunglasses. Australian maxi-CD single Sales+streaming figures based on certification alone. Rob Thomas (musician) Robert Kelly Thomas (born February 14, 1972) is an American musician. He

4224-426: The band, leaving only four of them. They decided to release a greatest hits album, Exile on Mainstream , which included an additional six new songs. The album released three singles: " How Far We've Come ", " All Your Reasons ", and " These Hard Times ". The album debuted at number 3. On September 15, 2008, Thomas told Billboard his second solo album was tentatively called Cradle Songs . Thomas characterized

4312-415: The cancer has become and whether or not it has favorable features. If the disease is detected early, a cure is often possible. In the United States, 88% of people diagnosed with Hodgkin lymphoma survive for five years or longer . For those under the age of 20, rates of survival are 97%. Radiation and some chemotherapy drugs, however, increase the risk of other cancers, heart disease , or lung disease over

4400-527: The care of Richard Bright , one was of Thomas Addison , and one was of Robert Carswell . Carswell's report of the seventh case was accompanied by numerous illustrations that aided early descriptions of the disease. Hodgkin's report on the seven cases, entitled "On some morbid appearances of the absorbent glands and spleen", was presented to the Medical and Chirurgical Society of London in January 1832 and

4488-510: The chest, abdomen and pelvis, and usually a bone marrow biopsy. PET scan is now used instead of the gallium scan for staging. On the PET scan, sites involved with lymphoma light up very brightly enabling accurate and reproducible imaging. In the past, a lymphangiogram or surgical laparotomy (which involves opening the abdominal cavity and visually inspecting for tumors) were performed. Lymphangiograms or laparotomies are very rarely performed, having been supplanted by improvements in imaging with

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4576-402: The chorus. He was inspired both by his wife, who is half-Spanish and half-Puerto-Rican, and by Santana himself. When he finished the song, he was unsure whether it was any good. His wife listened to the demo and told him, "This is going to be huge." Santana heard the demo and said he couldn't determine at first whether it was a male or female singing. He had no idea who Thomas was, but he liked

4664-553: The classic form. Other risk factors include a family history of the condition and having HIV/AIDS . Diagnosis is conducted by confirming the presence of cancer and identifying RS cells in lymph node biopsies. The virus-positive cases are classified as a form of the Epstein–Barr virus-associated lymphoproliferative diseases . Hodgkin lymphoma may be treated with chemotherapy , radiation therapy , and stem-cell transplantation . The choice of treatment often depends on how advanced

4752-409: The concert. Thomas announced on February 15, 2019, that his fourth studio album—titled Chip Tooth Smile —would be released on April 26, 2019. The lead single for the album, " One Less Day (Dying Young) ", was released on February 20, 2019. On October 7, 2021, Thomas announced that his first Christmas studio album titled "Something About Christmas Time" will be released on October 22. He recorded

4840-488: The disease. Hodgkin lymphoma accounts for less than 1% of all cancer cases and deaths in the UK. Around 1,800 people were diagnosed with the disease in 2011, and around 330 people died in 2012. In 2016, there were 8,389 new cases and 1,000 mortalities attributed to Hodgkin lymphoma, a decrease from the 8,625 new cases and 1,120 mortalities in 2015. As of January 1, 2016, the 5-year limited duration prevalence of Hodgkin lymphoma

4928-495: The disease. The number of cases of Hodgkin lymphoma is increased in people with HIV infection. In contrast to many other lymphomas associated with HIV infection it occurs most commonly in people with higher CD4 T cell counts. Hodgkin lymphoma accounts for 0.6% of all male cancer cases, and 0.4% of all female cancer cases in Canada. In 2017, approximately 990 Canadians will be diagnosed with Hodgkin lymphoma, and 140 will die of

5016-462: The elderly patient is not comparable to that of younger people and the disease is a different entity in older people where different considerations enter into treatment decisions. Recently, two novel targeted drugs have been developed for relapsing and refractory HL patients; Brentuximab vedotin, a CD30 antibody conjugated with a cytotoxic component MMAE, and the checkpoint inhibitors, Nivolumab and Pembrolizumab. This has been an important step in

5104-403: The first single from The Great Unknown , "Trust You", on May 25, 2015. The Great Unknown was released on August 21, 2015. He spent two years touring it prior. "Hold on Forever" was announced as the album's second single on September 28. The tour for Thomas' album included holographic representations of Thomas produced with vntana technology so that fans could pose for photos with him during

5192-464: The first time, the band recorded a song not written by Thomas. Two other songs were jointly attributed to Thomas, Cook, and Doucette. As part of the promotion for the album, Thomas and his bandmates were featured on VH1 's Behind the Music . When the tour for More Than You Think You Are ended, Thomas, Cook, Doucette, Yale, and Gaynor decided to take a break to focus on their families. In June 2004,

5280-434: The lymphocyte predominant subtype has been recently reviewed. The evidence is very uncertain about the effect of Nivolumab for patients with a Hodgkin's lymphoma e.g. on the overall survival. Increased age is an adverse risk factor for Hodgkin lymphoma, but in general elderly people (≥ 60 years of age) without major comorbidities are sufficiently fit to tolerate therapy with curative intent. Despite this, treatment outcome in

5368-427: The lyrics and melody could be strengthened. One of the executives sent the demo to Thomas, asking him if he'd like to work on it. Thomas had never worked on a song that he didn't intend to perform, and he was interested in the opportunity to try something new. He wrote the song intending for it to be sung by George Michael . Thomas wrote the verses to the song that became " Smooth ", and he and Shur collaborated on

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5456-425: The most effective combination, MOPP is still used after relapse or where the person has certain allergies or lung or heart problems which prevents the use of another regimen. The common non-Hodgkin treatment, rituximab (which is a monoclonal antibody against CD20) is not routinely used to treat Hodgkin lymphoma due to the lack of CD20 surface antigens in most cases. The use of rituximab in Hodgkin lymphoma, including

5544-504: The next Matchbox Twenty album. He gathered in Nashville, Tennessee , with his bandmates to narrow down the work he had already done and develop new material. The group members disagreed on which musical direction the new album should take. For three months, they argued and drank, in what Thomas describes as a "$ 100,000 bender". Finally, producer Serletic appeared and told them to stop drinking and get to work. The lecture worked. The result

5632-425: The past few decades. Recent trials that have made use of new types of chemotherapy have indicated higher survival rates than have previously been seen. In a 2007 European trial, the five-year survival rate for those people with a favorable prognosis (FFP) was 98%, while that for people with worse outlooks was at least 85%. In 1998, an international effort identified seven prognostic factors that accurately predict

5720-623: The patient's lymph nodes. The condition was named after the English physician Thomas Hodgkin , who first described it in 1832. Symptoms may include fever , night sweats , and weight loss . Often, nonpainful enlarged lymph nodes occur in the neck, under the arm, or in the groin . Persons affected may feel tired or be itchy. The two major types of Hodgkin lymphoma are classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma . About half of cases of Hodgkin lymphoma are due to Epstein–Barr virus (EBV) and these are generally

5808-588: The radiation therapy field. Most people with early-stage disease are now treated with abbreviated chemotherapy and involved site radiation therapy rather than with radiation therapy alone. Clinical research strategies are exploring reduction of the duration of chemotherapy and dose and volume of radiation therapy in an attempt to reduce late morbidity and mortality of treatment while maintaining high cure rates. Hospitals are also treating those who respond quickly to chemotherapy with no radiation. In childhood cases of Hodgkin lymphoma, long-term endocrine adverse effects are

5896-764: The songs to their rotations. Executives at Atlantic Records noticed that the songs were being requested frequently. Although the band sounded very green, executives thought the songs were good. The band was soon signed to Atlantic subsidiary Lava Records . Thomas wrote every song on Matchbox 20's debut album, Yourself or Someone Like You . It was released in October 1996, on the same day that Lava Records folded. The album sold only 600 copies in its first week. The band toured extensively, trying to attract notice. Radio stations were slow to adopt their first single, " Long Day ". Thomas and his bandmates were convinced they were soon to be dropped from their contract. Their manager

5984-402: The stage, subscript "E" is added. Splenic involvement is signified by adding "S" to the stage. The inclusion of "bulky disease" is signified by "X". Affected lymph nodes (most often, laterocervical lymph nodes) are enlarged, but their shape is preserved because the capsule is not invaded. Usually, the cut surface is white-grey and uniform; in some histological subtypes (e.g. nodular sclerosis )

6072-482: The standard treatment for adult patients with haematological malignancies like Hodgkin lymphoma may result in little to no difference in the mortality, the quality of life and the physical functioning. These exercises may result in a slight reduction in depression. Furthermore, aerobic physical exercises probably reduce fatigue. The evidence is very uncertain about the effect on anxiety and serious adverse events.   Treatment of Hodgkin's disease has been improving over

6160-503: The subsequent decades. In 2015, about 574,000 people globally had Hodgkin lymphoma, and 23,900 (4.2%) died. In the United States, 0.2% of people are affected at some point in their life. Most people are diagnosed with the disease between the ages of 20 and 40. People with Hodgkin lymphoma may present with these symptoms: Hodgkin lymphoma must be distinguished from noncancerous causes of lymph node swelling (such as various infections) and from other types of cancer. Definitive diagnosis

6248-405: The success rate of conventional treatment in people with locally extensive or advanced-stage Hodgkin lymphoma. Freedom from progression (FFP) at five years was directly related to the number of factors present in a person. The five-year FFP for people with zero factors is 84%. Each additional factor lowers the five-year FFP rate by 7%, such that the five-year FFP for a person with five or more factors

6336-520: The treatment for the few, but still existing refractory patients. For Hodgkin lymphomas, radiation oncologists typically use external beam radiation therapy (sometimes shortened to EBRT or XRT). Radiation oncologists deliver external beam radiation therapy to the lymphoma from a machine called a linear accelerator which produces high energy X-rays and electrons. People usually describe treatments as painless and similar to getting an X-ray. Treatments last less than 30 minutes each. For lymphomas, there are

6424-511: The twenty-four songs recorded during the album sessions. All twenty-four tracks were fully mixed and mastered, leaving plenty of material left over for B-sides, iTunes, or EPs. On June 9, 2009, Thomas released " Give Me the Meltdown " to the US iTunes Store . Similarly, " Someday " was released on June 16. On June 22, Cradlesong was made available for streaming only on the we7 website, one week ahead of its UK release date. Thomas promoted

6512-467: The two types differ. Classic Hodgkin lymphoma (excluding nodular lymphocyte predominant Hodgkin lymphoma ) can be subclassified into four pathologic subtypes based upon Reed–Sternberg cell morphology and the composition of the reactive cell infiltrate seen in the lymph node biopsy specimen (the cell composition around the Reed–Sternberg cell(s)). Presence of EBV in Reed-Sternberg cells

6600-559: The voice and asked that Thomas sing on the record. When they first met, Santana asked Thomas if he was married to a Latin woman. The song was recorded live, in three takes. Thomas was not aware that it was going to be released as a single until he heard it on the radio. It was a massive hit, spending 58 weeks on the Billboard Hot 100 chart. Billboard later named it the number 2 Hot 100 song of all time. It won three Grammy Awards, for Best Record, Best Song, and Best Pop Collaboration with Vocals. Its success earned him instant credibility as

6688-727: Was "rock star", and he often dressed the part, wearing sunglasses and long furry coats. He's described the first few years with Matchbox 20 as a blur, featuring large quantities of alcohol, cocaine, and sexual relationships with women. One of those interludes resulted in a son. The constant partying took a toll on Thomas and the band. Thomas concedes that the shows were beginning to suffer. He gained more than 50 pounds (23 kg). The weight gain earned them their first mention in Rolling Stone —an item making fun of Thomas. The band members decided together that they wanted to be more professional and began cleaning themselves up. Cocaine use

6776-460: Was 12, his mother was diagnosed with Hodgkins lymphoma and given only six months to live. His sister ran away from home to get married, leaving Thomas to care for their mother on his own. She eventually entered remission. Mamie dated a series of men, some of whom beat her, and she loved wild parties. Thomas sometimes woke up to find "10 strangers sleeping off last night's booze-a-thon in the living room". He attended Lake Brantley High School in

6864-430: Was 37,513 representing 0.71% of all diagnosed cancers in the U.S. Hodgkin lymphoma was first described in an 1832 report by Thomas Hodgkin , although Hodgkin noted that perhaps an earlier reference to the condition was provided by Marcello Malpighi in 1666. While occupied as museum curator at Guy's Hospital , London, Hodgkin studied seven people with painless lymph node enlargement. Of the seven cases, two were under

6952-510: Was a true collaboration. For the first time, the band recorded several songs written solely by Doucette and Yale. Matchbox Twenty's next album, North , was released on September 4, 2012, ten years after their last full-length album of new material. It debuted at number 1 on the Billboard Top 200 chart. Thomas performed several new album tracks in early 2015: "Hold On Forever", "Great Unknown", and "Heaven Help Me". Thomas released

7040-517: Was also worried, and yelled at them to get serious about their performances. Their fears were well-founded. Officials at Atlantic were close to dropping the band when they noticed that sales had spiked in Birmingham, Alabama . There, radio stations had begun playing another track on the album, " Push ". Atlantic released "Push" as a single, and it soon became a Top 5 hit. Its success led the album to be certified gold . Their next single, "3 A.M.",

7128-413: Was an alcoholic. She owned a small country store and gas station, where she also sold moonshine and marijuana under the counter. He grew up listening to country music and idolized the "big stars who lived ... hard lives", like Johnny Cash and Merle Haggard . Their stories inspired him to be a songwriter. Thomas and his mother and sister moved to Sarasota, Florida , when he was 10, then settled in

7216-406: Was concerned with how Thomas would manage everyday activities, Thomas cried and asked, "How am I going to get these songs in my head out if I can't play them?" In 1993, Thomas formed the band Tabitha's Secret . Brian Yale was the group's bass player. Paul Doucette earned a spot as drummer after answering an ad. Guitarists Jay Stanley and John Goff rounded out the band. The band was popular in

7304-599: Was his first to be released as a lead solo artist. It peaked at number six on the chart and led his debut solo album, ...Something to Be (2005), which peaked atop the Billboard 200 . As part of Matchbox Twenty, Thomas has written and performed their string of commercially successful singles, including " Push ", " 3AM ", " Real World ", " Back 2 Good ", " Bent ", " If You're Gone ", " Mad Season ", " Disease ", " Unwell ", " Bright Lights ", " How Far We've Come ", and " She's So Mean ". Outside of recording, Thomas has also been

7392-568: Was hugely popular, and the album went multi-platinum. " Real World ", and " Back 2 Good " followed. Nearly seven months after its release, the album reached number 99 on the Billboard 200 chart. It continued to climb, finally reaching as high as number 5. The album was nominated for a Grammy Award and two American Music Awards . In 1997, readers of Rolling Stone named Matchbox 20 the best new band. Thomas enjoyed his success. When travelling, he'd tell customs officials that his occupation

7480-515: Was more pop than Thomas's Matchbox Twenty work, adding quirks like sampling and loops . It earned two Grammy nominations, for Best Male Pop Vocal Performance and Best Solo Rock Vocal Performance. His first single from the album, " Lonely No More ", reached number six on the U.S. Billboard Hot 100 chart. The single debuted in the top 10 of the Australian ARIA singles chart on the week of April 4, 2005. The second single, " This Is How

7568-408: Was no longer tolerated. In 1998, Thomas was named one of People magazine's 50 Most Beautiful People . In 1999, Latin guitarist Carlos Santana began putting together his comeback album, Supernatural , a series of duets. He was looking for one last song to complete the album. Songwriter Itaal Shur had given a demo tape to Santana's representatives. Although they liked the music, they thought

7656-431: Was subsequently published in the society's journal, Medical-Chirurgical Society Transactions . Hodgkin's paper went largely unnoticed, however, even though Bright highlighted it in an 1838 publication. Indeed, Hodgkin himself did not view his contribution as particularly significant. In 1856, Samuel Wilks independently reported on a series of patients with the same disease that Hodgkin had previously described. Wilks,

7744-691: Was subsequently released as a single. In January 2007, Thomas released a single entitled " Little Wonders " from the soundtrack to the Disney animated feature, Meet the Robinsons . "Little Wonders" reached No. 5 on the Mediabase Hot Adult Contemporary chart. Thomas was featured on the June 14, 2007, episode of the long-running PBS series Soundstage . Thomas reunited with his Matchbox Twenty bandmates in 2007. Gaynor had left

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