114-782: The Main Ingredient was an American soul and R&B group which had a run of hits in the 1970s, including their 1972 million-selling song " Everybody Plays the Fool ". The group was formed in Harlem , New York City in 1964 as a trio called the Poets, composed of lead singer Donald McPherson (July 9, 1941 – July 3, 1971), Luther Simmons Jr. (September 9, 1942 – May 9, 2016), and Panama-born Tony Silvester (October 7, 1941 – November 26, 2006). They made their first recordings for Leiber & Stoller 's Red Bird label, but soon changed their name to
228-412: A call and response between the lead and backing vocalists , an especially tense vocal sound, and occasional improvisational additions, twirls, and auxiliary sounds. Soul music is known for reflecting African-American identity and stressing the importance of African-American culture. Soul music dominated the U.S. R&B charts in the 1960s, and many recordings crossed over into the pop charts in
342-409: A " Third British Invasion " or "British Soul Invasion" in the 2000s and 2010s. Neo soul is a blend of 1970s soul-style vocals and instrumentation with contemporary R&B sounds, hip-hop beats, and poetic interludes. The style was developed in the early to mid-1990s, and the term was coined in the early 1990s by producer and record label executive Kedar Massenburg . A key element in neo-soul
456-580: A Thousand Dances ") and Thee Midniters played brown-eyed R&B music with a rebellious rock and roll edge. Many of these artists drew from the frat rock and garage rock scenes. However, the large Hispanic population on the West Coast began gradually moving away from energetic R&B to romantic soul, and the results were "some of the sweetest soul music heard during the late 1960s and 1970s." Multiple myeloma Multiple myeloma ( MM ), also known as plasma cell myeloma and simply myeloma ,
570-559: A Top 10 Pop and R&B smash with their production of Ben E. King 's hit " Supernatural Thing " in 1975. Silvester was replaced by Carl Tompkins, and Gooding departed for a solo career on Motown in 1977, which produced two albums; Simmons, meanwhile, left the music industry to work as a stockbroker. Gooding, Silvester and Simmons reunited as the Main Ingredient in 1979, and recorded two more albums, 1980's Ready for Love and 1981's I Only Have Eyes for You (the latter featured
684-401: A Woman ". Singer Bobby Womack said, "Ray was the genius. He turned the world onto soul music." Charles was open in acknowledging the influence of Pilgrim Travelers vocalist Jesse Whitaker on his singing style. Little Richard , who inspired Otis Redding , and James Brown both were equally influential. Brown was nicknamed the "Godfather of Soul Music", and Richard proclaimed himself as
798-523: A backing vocalist on some of their previous recordings, and had filled in on tour during McPherson's brief illness. The Gooding era began auspiciously with the million-selling smash " Everybody Plays the Fool ", which hit number two R&B and number three pop to become the group's biggest hit. It sold over one million copies and was awarded a gold disc by the R.I.A.A. in September 1972. The accompanying album, Bitter Sweet , became their first to hit
912-488: A clone of bone marrow plasma cells that causes the asymptomatic disorder MGUS , which is a premalignant disorder characterized by increased numbers of plasma cells in the bone marrow or the circulation of a myeloma protein immunoglobulin. Further genetic or epigenic changes produce a new clone of bone marrow plasma cells, usually descendant from the original clone, that causes the more serious, but still asymptomatic premalignant disorder smoldering multiple myeloma. This myeloma
1026-501: A diplomat until 1944 when his father died, founded Atlantic Records in 1947 with his friend Herb Abramson . Ertegun wrote many songs for Ray Charles and the Clovers . He even sang backup vocals for his artist Big Joe Turner on the song, "Shake Rattle and Roll". Dominated by Berry Gordy 's Motown Records empire, Detroit's soul is strongly rhythmic and influenced by gospel music. The Motown sound often includes hand clapping ,
1140-494: A distinctive New Orleans soul sound that generated a passel of national hits. Other notable New Orleans hits came from Robert Parker, Betty Harris , and Aaron Neville . While record labels in New Orleans largely disappeared by the mid-1960s, producers in the city continued to record New Orleans soul artists for other mainly New York City and Los Angeles–based record labels—notably Lee Dorsey for New York-based Amy Records and
1254-548: A distinctive sound, which included putting vocals further back in the mix than most contemporary R&B records, using vibrant horn parts in place of background vocals, and a focus on the low end of the frequency spectrum. The vast majority of Stax releases were backed by house bands Booker T & the MGs (with Booker T. Jones , Steve Cropper , Duck Dunn , and Al Jackson ) and the Memphis Horns (the splinter horn section of
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#17327979428301368-648: A franchise that saw the creation of a record label ( Soul Train Records ) that distributed music by the Whispers , Carrie Lucas , and an up-and-coming group known as Shalamar . Numerous disputes led to Cornelius spinning off the record label to his talent booker, Dick Griffey , who transformed the label into Solar Records , itself a prominent soul music label throughout the 1980s. The TV series continued to air until 2006, although other predominantly African-American music genres such as hip-hop began overshadowing soul on
1482-466: A fundamental genetic instability in plasma cells or their precursors leads to the progression: Monoclonal gammopathy of undetermined significance → smoldering multiple myeloma → multiple myeloma → plasma cell leukemia Being asymptomatic, monoclonal gammopathy of undetermined significance and smoldering multiple myeloma are typically diagnosed fortuitously by detecting a myeloma protein on serum protein electrophoresis tests done for other purposes. MGUS
1596-521: A huge impact on the pop and R&B charts and a huge direct influence on the birth of Funk music. The principal architect of Crescent City's soul was a songwriter, arranger, and producer Allen Toussaint . He worked with such artists as Irma Thomas ("the Soul Queen of New Orleans"), Jessie Hill, Chris Kenner , Benny Spellman, and Ernie K-Doe on the Minit/Instant label complex to produce
1710-520: A large cell two or three times the size of a peripheral lymphocyte. Because they are actively producing antibodies, the Golgi apparatus typically produces a light-colored area adjacent to the nucleus, called a perinuclear halo. The single nucleus (with inside a single nucleolus with vesicular nuclear chromatin) is eccentric, displaced by an abundant cytoplasm. Other common morphologies seen, but which are not usual in normal plasma cells, include: Historically,
1824-429: A minor hit in "Evening of Love"). The trio reunited for a second time in 1986, but their Zakia single "Do Me Right" flopped, and Simmons returned to his day job. He was replaced by Jerome Jackson on the 1989 Polydor album I Just Wanna Love You . In the wake of Aaron Neville 's Top Ten revival of "Everybody Plays the Fool", Gooding resumed his solo career and issued his third album in 1993. Silvester and Simmons re-formed
1938-507: A multiple myeloma specific gene silencing pattern associated with abnormal histone modifications caused by dysregulation of the polycomb repressive complex 2 (PRC2). Increased expression of the PRC2 subunit, EZH2 have been described to be a common feature in multiple myeloma, resulting in an accumulation and redistribution of histone H3 lysine 27 trimethylation which advances with disease severity. Genetic abnormalities in multiple myeloma divide
2052-522: A newfound sophisticated musicality and ambitious lyricism in black pop. Among these musicians were Sly Stone , Stevie Wonder , Marvin Gaye , Curtis Mayfield , and George Clinton . In discussing the progressive soul of the 1970s, Martin cites this period's albums from Wonder ( Talking Book , Innervisions , Songs in the Key of Life ), War ( All Day Music , The World Is a Ghetto , War Live ), and
2166-482: A person's immune response is typically performed by a lab test that measures the levels of different immunoglobulins in the blood. There are five varieties of immunoglobulins, indicated by the suffices -A, -D, -E, -G and -M. In the aggregate, the immunoglobulin level may be elevated with the disease, but the majority of such increased antibodies are of a monoclonal variety due to the clonal plasma cell and are thus ineffective. Such ineffective antibodies are commonly of
2280-548: A powerful bassline , strings , brass and vibraphone . Motown Records' house band was the Funk Brothers . AllMusic cites Motown as the pioneering label of pop-soul, a style of soul music with raw vocals, but polished production and toned-down subject matter intended for pop radio and crossover success. Artists of this style included Diana Ross , the Jackson 5 , Stevie Wonder , and Billy Preston . Popular during
2394-405: A series of soul ballads characterized by unabashedly sentimental lyrics usually begging forgiveness or asking a girlfriend to come home... He soon became known as "Mr. Pitiful" and earned a reputation as the leading performer of soul ballads. The most important female soul singer to emerge was Aretha Franklin , originally a gospel singer who began to make secular recordings in 1960 but whose career
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#17327979428302508-569: A sound, it’s also a look. It comes with fashion that breaks barriers and shows creativity. The whole aesthetic is art, from the sound to the look. Neo-soul is a blend of music and culture and its impact in the music industry is timeless. Its impact can still be seen and felt across many genres and artists. Northern soul is a music and dance movement that emerged in the late 1960s out of the British mod subculture in Northern England and
2622-452: A specific set of "CRAB" symptoms, which are the basis for diagnosing malignant multiple myeloma and treating the disease. In a small percentage of multiple myeloma cases, further genetic and epigenetic changes lead to the development of a plasma cell clone that moves from the bone marrow into the circulatory system , invades distant tissues, and thereby causes the most malignant of all plasma cell dyscrasias , plasma cell leukemia . Thus,
2736-491: A successful pop music career. Furthermore, his 1962 recording of " Bring It On Home To Me " has been described as "perhaps the first record to define the soul experience". Jackie Wilson, a contemporary of both Cooke and James Brown, also achieved crossover success, especially with his 1957 hit " Reet Petite ". He even was particularly influential for his dramatic delivery and performances. Husband-wife duo Ike & Tina Turner emerged as "leading exponents" of soul music in
2850-454: Is R&B or soul music performed by white artists. The meaning of blue-eyed soul has evolved over the decades. Originally the term was associated with mid-1960s white artists who performed soul and R&B that was similar to the music released by Motown Records and Stax Records . The Righteous Brothers, the Rascals , Spencer Davis Group, Steve Winwood , Van Morrison & Them, and
2964-525: Is brown-eyed soul , or soul music or R&B created and performed mainly by Latinos in Southern California during the 1960s, continuing through to the early 1980s. The genre of soul music occasionally draws from Latin , and often contains rock music influences. This contrasts with blue-eyed soul, soul music performed by non-Hispanic white artists. Ritchie Valens , one of the original pioneers of brown-eyed soul music, also became one of
3078-446: Is a cancer of plasma cells , a type of white blood cell that normally produces antibodies . Often, no symptoms are noticed initially. As it progresses, bone pain , anemia , renal insufficiency , and infections may occur. Complications may include hypercalcemia and amyloidosis . The cause of multiple myeloma is unknown. Risk factors include obesity , radiation exposure, family history, age and certain chemicals. There
3192-626: Is a distant third in the causation. People with amyloidosis have high levels of amyloid protein that can be excreted through the kidneys and cause damage to the kidneys and other organs. Light chains produce myriad effects that can manifest as the Fanconi syndrome ( type II kidney tubular acidosis ). Collateral infections are common with multiple myeloma, since the disease impairs functioning of blood components that normally resist pathogens. The most common infections are pneumonias, urinary tract infections, and sepsis. The greatest risk period for
3306-408: Is a heavy dose of Fender Rhodes or Wurlitzer electric piano "pads" over a mellow, grooving interplay between the drums (usually with a rim shot snare sound) and a muted, deep funky bass. The Fender Rhodes piano sound gives the music a warm, organic character. Notable artists include Jill Scott, Lauryn Hill, and Erykah Badu. Also newer artists like H.E.R and Sza are influenced by Neo Soul. Neo Soul
3420-545: Is a relatively stable condition afflicting 3% of people aged 50 and 5% of people aged 70; it progresses to multiple myeloma at a rate of 0.5–1% cases per year; smoldering multiple myeloma does so at a rate of 10% per year for the first 5 years, but then falls off sharply to 3% per year for the next 5 years and thereafter to 1% per year. Overall, some 2–4% of multiple myeloma cases eventually progress to plasma cell leukemia . The globulin level may be normal in established disease. A doctor may request protein electrophoresis of
3534-431: Is an increased risk of multiple myeloma in certain occupations. This is due to the occupational exposure to aromatic hydrocarbon solvents having a role in causation of multiple myeloma. Multiple myeloma is the result of a multi-step malignant transformation, and almost universally originates from the pre-malignant stage monoclonal gammopathy of undetermined significance (MGUS). As MGUS evolves into MM, another pre-stage of
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3648-595: Is associated with multiple myeloma, particularly in individuals who have an immunodeficiency due to e.g. HIV/AIDS , organ transplantation , or a chronic inflammatory condition such as rheumatoid arthritis . EBV-positive multiple myeloma is classified by the World Health Organization (2016) as one form of the Epstein–Barr virus-associated lymphoproliferative diseases and termed Epstein–Barr virus-associated plasma cell myeloma . EBV-positive disease
3762-457: Is characterized by a rise in the number of bone marrow plasma cells or levels of the circulating myeloma protein above that seen in MGUS. Subsequent genetic and epigenetic changes lead to a new, more aggressive clone of plasma cells, which cause further rises in the level of the circulating myeloma protein, further rises in the number of bone marrow plasma cells, or the development of one or more of
3876-545: Is commonly seen, though this is not specific. The recent introduction of a commercial immunoassay for measurement of free light chains potentially offers an improvement in monitoring disease progression and response to treatment, particularly where the paraprotein is difficult to measure accurately by electrophoresis (for example in light chain myeloma, or where the paraprotein level is very low). Initial research also suggests that measurement of free light chains may also be used, in conjunction with other markers, for assessment of
3990-409: Is difficult to judge mortality statistics because treatments for the disease are advancing rapidly. Based on data concerning people diagnosed with the disease between 2013 and 2019, about 60% lived five years or more post-diagnosis, with about 34% living ten years or more. People newly diagnosed with the disease now have a better outlook, due to improved treatments. The disease usually occurs around
4104-537: Is due to proteins secreted by the malignant cells. Myeloma cells produce monoclonal proteins of varying types, most commonly immunoglobulins (antibodies) and free light chains , resulting in abnormally high levels of these proteins in the blood. Depending on the size of these proteins, they may be excreted through the kidneys. Kidneys can be damaged by the effects of proteins or light chains. Increased bone resorption leads to hypercalcemia and causes nephrocalcinosis , thereby contributing to kidney failure. Amyloidosis
4218-664: Is due to the exposure of different chemicals. Repeated exposure to chemicals increases risk of multiple myeloma. The use of pesticides and hazardous chemicals in occupations, like firefighting and agriculture have been seen to cause an increase of risk for multiple myeloma. Other occupations, such as the industrial occupations, are also at increased risk for multiple myeloma. Industrial workers are exposed to chemicals that have aromatic hydrocarbon solvents in them. Exposure to aromatic hydrocarbon solvents, benzene , toluene , and xylene , can increase risk of multiple myeloma. Increased duration, high intensity of exposure, or repeated exposure
4332-399: Is full of deep lyrics and soulful sounds that resonate with listeners. Neo Soul has had a lasting impact on the music industry, Along with a deep soulful sound, it also includes very soulful lyrics that touch on topics of love and even loss. This genre comes from African American culture and is connected to genres like gospel and blues. Fashion is also very important to this genre. It’s not just
4446-486: Is generally unknown. Studies have reported a familial predisposition to myeloma. Hyperphosphorylation of a number of proteins—the paratarg proteins—a tendency that is inherited in an autosomal dominant manner, appears a common mechanism in these families. This tendency is more common in African-Americans with myeloma and may contribute to the higher rates of myeloma in this group. In a study to investigate
4560-402: Is lost. Often, a promoter gene moves (or translocates) to a chromosome, where it stimulates an antibody gene to overproduction. A chromosomal translocation between the immunoglobulin heavy chain gene (on chromosome 14 , locus q32) and an oncogene (often 11q13, 4p16.3, 6p21, 16q23 and 20q11 ) is frequently observed in people with multiple myeloma. This mutation results in dysregulation of
4674-416: Is mainly due to casts of paraprotein deposition in the kidney, although the cast may also contain complete immunoglobulins, Tamm-Horsfall protein and albumin . Other useful laboratory tests include quantitative measurement of IgA, IgG, and IgM to look for immune paresis, and beta-2 microglobulin, which provides prognostic information. On peripheral blood smear, the rouleaux formation of red blood cells
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4788-584: Is more common in the plasmacytoma rather than multiple myeloma form of plasma cell cancer. Tissues involved in EBV+ disease typically show foci of EBV+ cells with the appearance of rapidly proliferating immature or poorly differentiated plasma cells. The cells express products of EBV genes such as EBER1 and EBER2. While the EBV contributes to the development and/or progression of most Epstein–Barr virus-associated lymphoproliferative diseases, its role in multiple myeloma
4902-616: Is not known. However, people who are EBV-positive with localized plasmacytoma(s) are more likely to progress to multiple myeloma compared to people with EBV-negative plasmacytoma(s). This suggest that EBV may have a role in the progression of plasmacytomas to systemic multiple myeloma. B lymphocytes start in the bone marrow and move to the lymph nodes. As they progress, they mature and display different proteins on their cell surfaces (cell surface antigens). When they are activated to secrete antibodies, they are known as plasma cells. Multiple myeloma develops in B lymphocytes after they have left
5016-627: Is one of the most common symptoms. Myeloma bone pain usually involves the spine and ribs, and worsens with activity. Persistent, localized pain may indicate a pathological bone fracture . Involvement of the vertebrae may lead to spinal cord compression or kyphosis . Myeloma bone disease is due to the overexpression of receptor activator for nuclear factor κ B ligand ( RANKL ) by bone marrow stroma . RANKL activates osteoclasts , which resorb bone. The resultant bone lesions are lytic (cause breakdown) in nature, and are best seen in plain radiographs, which may show "punched-out" resorptive lesions (including
5130-563: The English Midlands , based on a particular style of soul music with a heavy beat and fast tempo. The phrase northern soul was coined by a journalist Dave Godin and popularised through his column in Blues and Soul magazine. The rare soul records were played by DJs at nightclubs , and included obscure 1960s and early 1970s American recordings with an uptempo beat, such as those on Motown and smaller labels, not necessarily from
5244-680: The Northern United States . Many artists in various genres of electronic music (such as house , drum n bass , UK garage , and downtempo ) are heavily influenced by soul, and have produced many soul-inspired compositions. The impact of soul music was manifold; internationally, white and other non-black musicians were influenced by soul music. British soul and Northern soul , rare soul music played by DJs at nightclubs in Northern England, are examples. Several terms were introduced, such as " blue-eyed soul ", which
5358-647: The UK Singles Chart in July 1974, although it was their only chart presence in the UK. In 1975, the group recorded several songs co-written by Leon Ware , including the R&;B Top Ten "Rolling Down a Mountainside". By this point, however, Tony Silvester was harboring other ambitions; he released a solo album called Magic Touch that year, and left the group to form a production team with DeCoteaux. The two of them scored
5472-681: The civil rights movement . Soul also became popular worldwide, directly influencing rock music and the music of Africa . It had a resurgence in the mid-to late 1990s with the subgenre neo soul , which incorporated modern production elements and hip hop influences. The genre emerged from the power struggle to increase black Americans' awareness of their African ancestry, as a newfound consciousness led to new styles of music that boasted pride in being black. Soul music primarily combines elements of gospel, R&B and jazz . Catchy rhythms, stressed by handclaps and extemporaneous body movements, are an important hallmark of soul. Other characteristics are
5586-399: The diagnostic criteria for myeloma. Immunohistochemistry (staining particular cell types using antibodies against surface proteins) can detect plasma cells that express immunoglobulin in the cytoplasm and occasionally on the cell surface; myeloma cells are often CD56 , CD38 , CD138 , and CD319 positive and CD19 , CD20 , and CD45 negative. Flow cytometry is often used to establish
5700-562: The " Motown sound ", a more rhythmic and pop -friendly style that originated from the eponymous label; Southern soul , a driving, energetic variety combining R&B with southern gospel music influences; Memphis soul , a shimmering, sultry style; New Orleans soul , which emerged from the rhythm and blues style; Chicago soul , a lighter gospel-influenced sound; and Philadelphia soul , a lush orchestral variety with doo-wop -inspired vocals. Soul music has its roots in traditional African-American gospel music and rhythm and blues and as
5814-493: The "King of Rockin' and Rollin', Rhythm and Blues Soulin ' ", because his music embodied elements of all three, and since he inspired artists in all three genres. Sam Cooke and Jackie Wilson also are often acknowledged as soul forefathers. Cooke became popular as the lead singer of the gospel group the Soul Stirrers , before controversially moving into secular music. His recording of " You Send Me " in 1957 launched
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#17327979428305928-524: The "first clear evidence of soul music shows up with the "5" Royales , an ex-gospel group that turned to R&B and in Faye Adams , whose "Shake A Hand" becomes an R&B standard". Important innovators whose recordings in the 1950s contributed to the emergence of soul music included Clyde McPhatter , Hank Ballard , and Etta James . Ray Charles is often cited as popularizing the soul music genre with his series of hits, starting with 1954's " I Got
6042-610: The "raindrop" appearance of the skull on radiography). The breakdown of bone also leads to the release of calcium ions into the blood, leading to hypercalcemia and its associated symptoms. The anemia found in myeloma is usually normocytic and normochromic . It results from the replacement of normal bone marrow by infiltrating tumor cells and inhibition of normal red blood cell production ( hematopoiesis ) by cytokines . Impaired kidney function may develop, either acutely or chronically , and with any degree of severity. The most common cause of kidney failure in multiple myeloma
6156-572: The 1940s and '50s occasionally used the term as part of their names. The jazz style that originated from gospel became known as soul jazz . As singers and arrangers began using techniques from both gospel and soul jazz in African-American popular music during the 1960s, soul music gradually functioned as an umbrella term for African-American popular music at the time. According to the Acoustic Music Organization,
6270-603: The 1960s which were unable to connect with the mainstream market. Nevertheless, soul has been a major influence on British popular music since the 1960s including bands of the British Invasion , most significantly the Beatles . There were a handful of significant British blue-eyed soul acts, including Dusty Springfield and Tom Jones . In the 1970s Carl Douglas , the Real Thing and Delegation had hits in
6384-615: The 1960s, the style became glossier during the 1970s and led to disco . In the late 2000s, the style was revisited by contemporary soul singers such as Amy Winehouse , Raphael Saadiq (specifically his 2008 album The Way I See It ) and Solange Knowles (her 2008 album Sol-Angel and the Hadley St. Dreams ). The terms "deep soul" and "Southern soul" generally refer to a driving, energetic soul style combining R&B 's energy with pulsating southern United States gospel music sounds. Memphis, Tennessee , label Stax Records nurtured
6498-711: The 1960s. Their debut single " A Fool in Love " crossed over to the pop charts in 1960. They earned a Grammy nomination for their song " It's Gonna Work Out Fine " in 1962. Along with the Kings of Rhythm and the Ikettes , they toured the Chitlin’ Circuit as the Ike & Tina Turner Revue. Writer Peter Guralnick is among those to identify Solomon Burke as a key figure in the emergence of soul music, and Atlantic Records as
6612-814: The Dells and Billy Stewart . Curtis Mayfield not only scored many hits with his group, the Impressions , but wrote many hit songs for Chicago artists and produced hits on his own labels for the Fascinations , Major Lance , and the Five Stairsteps . Based primarily in the Philadelphia International record label, Philadelphia soul (or Philly Soul) had lush string and horn arrangements and doo-wop -inspired vocals. Thom Bell , and Kenneth Gamble & Leon Huff are considered
6726-694: The Grass Roots were famous blue-eyed soul musicians in the 1960s. The term continued to be used in the 1970s and 1980s, particularly by the British media to refer to a new generation of singers who adopted elements of the Stax and Motown sounds. To a lesser extent, the term has been applied to singers in other music genres that are influenced by soul music. Artists like Hall & Oates , David Bowie , Teena Marie , Hamilton, Joe Frank & Reynolds , Frankie Valli , Christina Aguilera , Amy Winehouse and Adele are known as blue-eyed soul singers. Another term
6840-569: The Insiders and signed with RCA Records . In 1968, after a couple of singles , they changed their name once again, this time permanently, to The Main Ingredient. The name came from a Coca-Cola bottle. They then teamed up with record producer/arranger Bert DeCoteaux. Under his direction, The Main Ingredient reached the R&;B Top 30 for the first time in 1970 with "You've Been My Inspiration". A cover of The Impressions ' " I'm So Proud " broke
6954-534: The Isley Brothers ( 3 + 3 ). Isaac Hayes 's 1969 recording of " Walk on By " is considered a "classic" of prog-soul, according to City Pages journalist Jay Boller. Later prog-soul music includes recordings by Prince , Peter Gabriel , Meshell Ndegeocello , Joi , Bilal , Dwele , Anthony David , Janelle Monáe , and the Soulquarians , an experimental black-music collective active during
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#17327979428307068-410: The Main Ingredient in 1999 with new lead singer Carlton Blount; this line-up recorded Pure Magic in 2001. Tony Silvester died after a six-year struggle with multiple myeloma on November 26, 2006, at the age of 65, and original member Luther Simmons retired shortly thereafter. Simmons died on May 9, 2016, at the age of 74. Cuba Gooding Sr. was found dead in his car on April 20, 2017. The line-up of
7182-538: The Mar-Keys , trumpeter Wayne Jackson and saxophonist Andrew Love ). "Memphis soul" is a shimmering, sultry style of soul music produced in the 1960s and 1970s at Stax Records and Hi Records in Memphis, Tennessee . It featured melancholic and melodic horns, Hammond organ , bass, and drums, as heard in recordings by Hi's Al Green and Stax's Booker T. & the M.G.'s . The latter group also sometimes played in
7296-829: The Meters . More versatile groups such as War , the Commodores , and Earth, Wind and Fire became popular around this time. During the 1970s, some slick and commercial blue-eyed soul acts like Philadelphia's Hall & Oates and Oakland's Tower of Power achieved mainstream success, as did a new generation of street-corner harmony or "city-soul" groups such as the Delfonics and the historically black Howard University 's Unifics . The syndicated music/dance variety television series Soul Train , hosted by Chicago native Don Cornelius , debuted in 1971. The show provided an outlet for soul music for several decades, also spawning
7410-476: The Meters for New York–based Josie and then LA-based Reprise. Chicago soul generally had a light gospel-influenced sound, but the large number of record labels based in the city tended to produce a more diverse sound than other cities. Vee Jay Records , which lasted until 1966, produced recordings by Jerry Butler , Betty Everett , Dee Clark , and Gene Chandler . Chess Records , mainly a blues and rock and roll label, produced several major soul artists, including
7524-552: The Top 10 on the R&B album chart; its follow-up, 1973's Afrodisiac , featured several songs written or co-written by Stevie Wonder , although it did not produce any huge successes on the singles charts. They peaked at number eight on the R&B chart in 1974 with " Just Don't Want to Be Lonely ", which sold over a million copies, and also reached number ten on the Billboard Hot 100 . The track peaked at number twenty-seven in
7638-558: The Top 20, and "Spinning Around (I Must Be Falling in Love)" went into the Top 10. In 1971, they scored again, with the McPherson-penned black-power anthem "Black Seeds Keep on Growing," but tragedy struck that year. Don McPherson, who had been suddenly taken ill with leukemia , died unexpectedly on July 3, 1971, at age 29. Stunned, Tony Silvester and Luther Simmons re-grouped with new lead singer Cuba Gooding Sr. , who had served as
7752-625: The U.S., United Kingdom, and elsewhere. Many prominent soul artists, including Ray Charles , Sam Cooke , Otis Redding , James Brown , Aretha Franklin , and various acts under the Motown label, such as The Supremes and The Temptations , were highly influential in the genre's development and all gained widespread popularity during this time. By 1968, the soul music genre had begun to splinter. Some soul artists moved to funk music, while other singers and groups developed slicker, more sophisticated, and in some cases more socially conscious varieties. By
7866-684: The U.S., including New York City, Detroit, Chicago, Memphis , New Orleans , Philadelphia , and Muscle Shoals, Alabama (the home of FAME Studios and Muscle Shoals Sound Studios ) became noted for different subgenres of the music and recording styles. By 1968, while at its peak of popularity, soul began to fragment into different subgenres. Artists such as James Brown and Sly and the Family Stone evolved into funk music, while other singers such as Marvin Gaye, Stevie Wonder, Curtis Mayfield and Al Green developed slicker, more sophisticated and in some cases more politically conscious varieties of
7980-492: The UK. American soul was extremely popular among some youth sub-cultures like the mod , Northern soul and modern soul movements, but a clear genre of British soul did not emerge until the 1980s when several artists including George Michael , Sade , Simply Red , Lisa Stansfield and Soul II Soul enjoyed commercial success. The popularity of British soul artists in the U.S., most notably Amy Winehouse , Adele , Estelle , Duffy , Joss Stone and Leona Lewis , led to talk of
8094-684: The Vandellas , and the Jackson Five . Hits were made using a quasi-industrial " production-line " approach. The producers and songwriters brought artistic sensitivity to the three-minute tunes. Brian Holland , Lamont Dozier and Eddie Holland were rarely out of the charts for their work as songwriters and record producers for the Supremes , the Four Tops and Martha and the Vandellas . They allowed important elements to shine through
8208-462: The activation of specific oncogenes and repression of specific tumor suppressor genes . The observed methylation pattern of CpG within intronic regions with enhancer-related chromatin marks in multiple myeloma is similar to undifferentiated precursor and stem cells. These results may represent a de novo epigenetic reprogramming in multiple myeloma, leading to the acquisition of a methylation pattern related to stemness. Other studies have identified
8322-492: The age of 60 and is more common in men than women. It is uncommon before the age of 40. The word myeloma is from Greek myelo- 'marrow' and -oma 'tumor'. Because many organs can be affected by myeloma, the symptoms and signs vary greatly. Fatigue and bone pain are the most common symptoms at presentation. The CRAB criteria were formerly the benchmark used to establish presence of active multiple myeloma (as opposed to an earlier, generally asymptomatic, "smoldering" form of
8436-458: The association between occupational exposure to aromatic hydrocarbon solvents ( Benzene and its many derivatives), evidence has shown that these solvents have a role in causation of multiple myeloma. The occurrence of multiple myeloma may occur more in certain occupations. The risk of multiple myeloma occurring is greater in occupations as a firefighter, as a hairdresser, and in agricultural and industrial occupations. The risk in certain occupations
8550-478: The blood and urine, which might show the presence of a paraprotein (monoclonal protein, or M protein ) band, with or without reduction of the other (normal) immunoglobulins (known as immune paresis). One type of paraprotein is the Bence Jones protein , which is a urinary paraprotein composed of free light chains. Quantitative measurements of the paraprotein are necessary to establish a diagnosis and to monitor
8664-410: The clonal nature of the plasma cells, which will generally express only kappa or lambda light chain. Cytogenetics may also be performed in myeloma for prognostic purposes, including a myeloma-specific fluorescent in situ hybridization and virtual karyotype . The plasma cells seen in multiple myeloma have several possible morphologies. First, they could have the appearance of a normal plasma cell,
8778-495: The day. They tended to have smaller ensembles marked by expressive gospel-tinged vocals. Brass and saxophones were also used extensively. Stax Records , founded by siblings Estelle and James Stewart, was the second most successful record label behind Motown Records . They were responsible for releasing hits by Otis Redding , Wilson Pickett , the Staple Singers , and many more. Ahmet Ertegun, who had anticipated being
8892-466: The dense musical texture. The rhythm was emphasized by handclaps or tambourine . Smokey Robinson was another writer and record producer who added lyrics to " The Tracks of My Tears " by his group the Miracles , which was one of the most important songs of the decade. Stax Records and Atlantic Records were independent labels that produced high-quality dance records featuring many well-known singers of
9006-695: The development of neo-soul around 1994. Berry Gordy 's successful Tamla/Motown group of labels was notable for being African-American owned, unlike most of the earlier independent R&B labels. Notable artists under this label were Gladys Knight & the Pips , the Supremes , the Temptations , the Miracles , the Four Tops , the Marvelettes , Mary Wells , Jr. Walker & the All-Stars , Stevie Wonder , Marvin Gaye , Tammi Terrell , Martha and
9120-497: The disease establishment and progression. In a study that investigated the DNA methylation profile of multiple myeloma cells and normal plasma cells , a gradual demethylation from stem cells to plasma cells was observed, with site-specific gain of methylation. Loss of methylation is associated with gene activation and gain of methylation is correlated with gene silencing. The dysregulated methylation pattern in multiple myeloma results in
9234-816: The disease in two main groups, hyperdiploid multiple myeloma and non-hyperdiploid multiple myeloma. Hyperdiploid MM is associated with good prognosis and includes trisomies of odd-numbered chromosomes. Non-hyperdiploid MM has worse outcome and is characterized by translocations on chromosome 14, which lead to the expression of oncogenes. These translocations can be t(11;14), t(6;14), t(4;14), t(14;16), t(14;20). Other genetic alterations are 1q amplification, deletion 1p, deletion 17, deletion 13, MYC overexpression, and point mutations in key pathways. Associated genetic mutations include ATM , BRAF , CCND1 , DIS3 , FAM46C , KRAS , NRAS and TP53 . The genetic and epigenetic changes occur progressively. The initial change, often involving one chromosome 14 translocation, establishes
9348-514: The disease is reached, known as smoldering myeloma (SMM) . In MM, the abnormal plasma cells produce abnormal antibodies , which can cause kidney problems and overly thick blood . The plasma cells can also form a mass in the bone marrow or soft tissue. When one tumor is present, it is called a plasmacytoma ; more than one is called multiple myeloma. Multiple myeloma is diagnosed based on blood or urine tests finding abnormal antibody proteins (often using electrophoretic techniques revealing
9462-554: The disease is well-controlled, neurological symptoms may result from current treatments, some of which may cause peripheral neuropathy, manifesting itself as numbness or pain in the hands, feet, and lower legs. The initial symptoms may involve pain, numbness, swelling, expansion of the jaw, tooth mobility, and radiolucency . Multiple myeloma in the mouth can mimic common tooth problems such as periapical abscess or periodontal abscess , gingivitis , periodontitis , or other gingival enlargement or masses. The cause of multiple myeloma
9576-582: The disease). The CRAB criteria are: As of 2014 the diagnostic criteria were expanded and updated by the IMWG (International Myeloma Working Group) to add three myeloma defining events, any one of which indicates presence of active multiple myeloma. Each of these three events may occur before any of the CRAB criteria appears, thereby making more people eligible for treatment with myeloma drugs earlier. Bone pain affects almost 70% of people with multiple myeloma and
9690-550: The disease. The paraprotein is a specific immunoglobulin (or fragment of immunoglobulin) originally produced by the mutated plasma cell which began to multiply, and which is now produced by the entire line of malignant cells. In theory, multiple myeloma can produce all classes of immunoglobulin, but IgG paraproteins are most common, followed by IgA and IgM . IgD and IgE myeloma are very rare. In addition, light and or heavy chains (the building blocks of antibodies) may be secreted in isolation: κ- or λ-light chains or any of
9804-439: The early 1970s, soul music had begun to absorb influences from psychedelic rock and progressive rock , among other genres, leading to the creation of psychedelic soul and progressive soul . Prominent soul artists of this era include Marvin Gaye , Stevie Wonder , Curtis Mayfield , Isaac Hayes , Al Green , and Bill Withers . Neo soul , which adopted hip hop influences, emerged around 1994. Other subgenres of soul include
9918-499: The evolution of soul music, although their recordings were considered more in a pop music vein than those of Redding, Franklin and Carr. Although stylistically different from classic soul music, recordings by Chicago -based artists are often considered part of the genre. By the early 1970s, soul music had been influenced by psychedelic rock and other genres. Artists like James Brown led soul towards funk music, which became typified by 1970s bands like Parliament-Funkadelic and
10032-523: The first brown-eyed soul artists to bring traditional Latin music and rock and roll influences into the genre. Latino groups on the East and West Coast also drew from the funk -influenced Philadelphia soul, or "Philly" soul . The West Coast Latin rock scene continued to influence brown-eyed soul artists as well. Inspired by Valens, 1960s and 1970s bands such as Cannibal & the Headhunters (" Land of
10146-451: The five types of heavy chains (α-, γ-, δ-, ε- or μ-heavy chains). People without evidence of a monoclonal protein may have "nonsecretory" myeloma (not producing immunoglobulins); this represents about 3% of all people with multiple myeloma. Additional findings may include a raised calcium level (when osteoclasts are breaking down bone, releasing it into the bloodstream), raised serum creatinine level due to reduced kidney function , which
10260-717: The founders of Philadelphia soul, which produced hits for Patti LaBelle , the O'Jays , the Intruders , the Three Degrees , the Delfonics , the Stylistics , Harold Melvin & the Blue Notes , and the Spinners . By the 1970s, African-American popular musicians had drawn from the conceptual album-oriented approach of the then-burgeoning progressive rock development. This progressive-soul development inspired
10374-476: The genre. However, soul music continued to evolve, informing most subsequent forms of R&B from the 1970s-onward, with pockets of musicians continuing to perform in traditional soul style. Mitchell's Hi Records continued in the Stax tradition of the previous decade, releasing a string of hits by Green, Ann Peebles , Otis Clay , O.V. Wright and Syl Johnson . Bobby Womack , who recorded with Chips Moman in
10488-703: The group consisted of Jerome Jackson and Stanley Alston. On August 13, 2020, Alston died from ALS in his hometown of Palm Coast, FL at age 66. Soul music See also: Soul music is a popular music genre that originated in African-American communities throughout the United States in the late 1950s and early 1960s. It has its roots in African-American gospel music and rhythm and blues . Soul music became popular for dancing and listening, and U.S. record labels such as Motown , Atlantic and Stax were influential in its proliferation during
10602-423: The harder-edged Southern soul style. The Hi Records house band ( Hi Rhythm Section ) and producer Willie Mitchell developed a surging soul style heard in the label's 1970s hit recordings. Some Stax recordings fit into this style but had their own unique sound. The New Orleans soul scene directly came out of the rhythm and blues era, when such artists as Little Richard , Fats Domino , and Huey Piano Smith made
10716-416: The hybridization of their respective religious and secular styles – in both lyrical content and instrumentation – that began in the 1950s. The term "soul" had been used among African-American musicians to emphasize the feeling of being an African-American in the United States. According to musicologist Barry Hansen , Though this hybrid produced a clutch of hits in the R&B market in the early 1950s, only
10830-421: The immunoglobulin -A and -G varieties. When the measure of effective antibodies drops below a threshold (a condition termed hypogammaglobulinemia ), supplemental immunoglobulins may be provided by periodic infusions to reduce the risk of collateral infections. Some symptoms (e.g., weakness , confusion , and fatigue ) may be due to anemia or hypercalcemia. Headache , visual changes, and retinopathy may be
10944-419: The influence of psychedelic soul continued on and remained prevalent through the 1970s. In the early 1960s, small soul scenes began popping up around the UK. Liverpool in particular had an established black community from which artists such as Chants and Steve Aldo emerged and go on to record within the British music industry. As a result, many recordings were commercially released by British soul acts during
11058-544: The key record label . Burke's early 1960s songs, including " Cry to Me ", " Just Out of Reach " and "Down in the Valley" are considered classics of the genre. Guralnick wrote: Soul started, in a sense, with the 1961 success of Solomon Burke's "Just Out Of Reach". Ray Charles, of course, had already enjoyed enormous success (also on Atlantic), as had James Brown and Sam Cooke — primarily in a pop vein. Each of these singers, though, could be looked upon as an isolated phenomenon; it
11172-562: The late 1960s, continued to produce soul recordings in the 1970s and 1980s. In Detroit , producer Don Davis worked with Stax artists such as Johnnie Taylor and the Dramatics . Early 1970s recordings by the Detroit Emeralds , such as Do Me Right , are a link between soul and the later disco style. Motown Records artists such as Marvin Gaye , Michael Jackson , Stevie Wonder and Smokey Robinson contributed to
11286-418: The late 1990s and early 2000s. Psychedelic soul, sometimes known as "black rock", was a blend of psychedelic rock and soul music in the late 1960s, which paved the way for the mainstream emergence of funk music a few years later. Early pioneers of this subgenre of soul music include Jimi Hendrix , Sly and the Family Stone , Norman Whitfield , and Isaac Hayes . While psychedelic rock began its decline,
11400-540: The most adventurous white fans felt its impact at the time; the rest had to wait for the coming of soul music in the 1960s to feel the rush of rock and roll sung gospel-style. According to AllMusic, "Soul music was the result of the urbanization and commercialization of rhythm and blues in the '60s." The phrase "soul music" itself, referring to gospel-style music with secular lyrics, was first attested in 1961. The term "soul" in African-American parlance has connotations of African-American pride and culture. Gospel groups in
11514-433: The most successful acts in this era include Smokey Robinson, Jeffry Osbourne, Peabo Bryson , Chaka Khan , and Larry Graham . After the decline of disco and funk in the early 1980s, soul music became influenced by electro music . It became less raw and more slickly produced, resulting in a style is known as contemporary R&B , which sounded very different from the original rhythm and blues style. The United States saw
11628-598: The occurrence of infection is in the initial few months after the start of a new drug therapy, since many drug therapies further suppress the normal immune response. Infections (and "adverse events" for all diseases) are graded by a standardized scale. With some myeloma drug therapies, over 30% of people experience a "Grade 3" or higher infection (many people experience multiple such infections), calling for intervention at least by antibiotics. Of people who die within 6 months of their myeloma diagnosis, between 20% and 50% die from collateral infections. Clinical evaluation of
11742-437: The oncogene which is thought to be an important initiating event in the pathogenesis of myeloma. The result is a proliferation of a plasma cell clone and genomic instability that leads to further mutations and translocations. The chromosome 14 abnormality is observed in about 50% of all cases of myeloma. Deletion of (parts of) chromosome 13 is also observed in about 50% of cases. Production of cytokines (especially IL-6 ) by
11856-422: The part of the lymph node known as the germinal center . The normal cell type most closely associated with MM cells is generally taken to be either an activated memory B cell or the precursor to plasma cells, the plasmablast . The immune system keeps the proliferation of B cells and the secretion of antibodies under tight control. When chromosomes and genes are damaged, often through rearrangement, this control
11970-455: The plasma cells causes much of their localized damage, such as osteoporosis , and creates a microenvironment in which the malignant cells thrive. Angiogenesis (the generation of new blood vessels) is increased. The produced antibodies are deposited in various organs, leading to kidney failure, polyneuropathy, and various other myeloma-associated symptoms. Epigenetic modifications , as DNA methylation or histone modifications , are key for
12084-661: The pop charts in the U.S. Otis Redding was a huge success at the Monterey Pop Festival in 1967. The genre also became highly popular in the UK, where many leading acts toured in the late 1960s. "Soul" became an umbrella term for an increasingly wide variety of R&B-based music styles – from the dance and pop-oriented acts at Motown Records in Detroit , such as the Temptations , Marvin Gaye and Stevie Wonder , to " deep soul " performers such as Percy Sledge and James Carr . Different regions and cities within
12198-585: The presence of a monoclonal spike in the results, termed an m-spike), bone marrow biopsy finding cancerous plasma cells, and medical imaging finding bone lesions. Another common finding is high blood calcium levels . Multiple myeloma is considered treatable, but generally incurable. Remissions may be brought about with steroids , chemotherapy , targeted therapy , and stem cell transplant . Bisphosphonates and radiation therapy are sometimes used to reduce pain from bone lesions. Recently, new approaches utilizing CAR-T cell therapy have been included in
12312-414: The result of hyperviscosity of the blood depending on the properties of the paraprotein . Finally, radicular pain , loss of bowel or bladder control (due to involvement of spinal cord leading to cord compression ) or carpal tunnel syndrome , and other neuropathies (due to infiltration of peripheral nerves by amyloid ) may occur. It may give rise to paraplegia in late-presenting cases. When
12426-496: The risk of progression from MGUS to multiple myeloma. This assay, the serum free light chain assay, has recently been recommended by the International Myeloma Working Group for the screening, diagnosis, prognosis, and monitoring of plasma cell dyscrasias . A bone marrow biopsy is usually performed to estimate the percentage of bone marrow occupied by plasma cells. This percentage is used in
12540-399: The show beginning in the 1980s. As disco and funk musicians had hits in the late 1970s and early 1980s, soul went in the direction of quiet storm . With its relaxed tempos and soft melodies, quiet storm soul took influences from fusion and adult contemporary . Some funk bands, such as EW&F, the Commodores and Con Funk Shun would have a few quiet storm tracks on their albums. Among
12654-402: The treatment regimes. Globally, about 175,000 people were diagnosed with the disease in 2020, while about 117,000 people died from the disease that year. In the U.S., forecasts suggest about 35,000 people will be diagnosed with the disease in 2023, and about 12,000 people will die from the disease that year. In 2020, there were an estimated 170,405 people living with myeloma in the U.S. It
12768-492: Was associated with an increased risk of multiple myeloma by up to 63%. The time from exposure to diagnosis was studied, and diagnosis after exposure lagged at least 20 years. When exposure to one chemical was identified, there was usually exposure to another hydrocarbon solvent identified. Multiple myeloma affects more men, older adults, and African Americans. These populations also have higher exposure frequencies than their female counterparts. Rarely, Epstein–Barr virus (EBV)
12882-447: Was later revitalized by her recordings for Atlantic. Her 1967 recordings, such as " I Never Loved a Man (The Way I Love You) ", " Respect " (written and originally recorded by Otis Redding), and " Do Right Woman, Do Right Man " (written by Chips Moman and Dan Penn ), were significant and commercially successful recordings. Soul music dominated the U.S. African-American music charts in the 1960s, and many recordings crossed over into
12996-557: Was only with the coming together of Burke and Atlantic Records that you could begin to see anything even resembling a movement. Ben E. King also achieved success in 1961 with " Stand By Me ", a song directly based on a gospel hymn. By the mid-1960s, the initial successes of Burke, King, and others had been surpassed by new soul singers, including Stax artists such as Otis Redding and Wilson Pickett , who mainly recorded in Memphis, Tennessee , and Muscle Shoals, Alabama . According to Jon Landau : Between 1962 and 1964 Redding recorded
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