The no-observed-adverse-effect level ( NOAEL ) denotes the level of exposure of an organism , found by experiment or observation , at which there is no biologically or statistically significant increase in the frequency or severity of any adverse effects of the tested protocol. In drug development, the NOAEL of a new drug is assessed in laboratory animals, such as mice , prior to initiation of human trials in order to establish a safe clinical starting dose in humans. The OECD publishes guidelines for Preclinical Safety Assessments , in order to help scientists discover the NOAEL.
21-434: Some adverse effects in the exposed population when compared to its appropriate control might include alteration of morphology , functional capacity, growth , development or life span. The NOAEL is determined or proposed by qualified personnel, often a pharmacologist or a toxicologist . The NOAEL could be defined as "the highest experimental point that is without adverse effect," meaning that under laboratory conditions, it
42-469: A "good" or "useful" taxon is commonly taken to be one that reflects evolutionary relationships . Many modern systematists, such as advocates of phylogenetic nomenclature , use cladistic methods that require taxa to be monophyletic (all descendants of some ancestor). Therefore, their basic unit, the clade , is equivalent to the taxon, assuming that taxa should reflect evolutionary relationships. Similarly, among those contemporary taxonomists working with
63-475: A narrow set of ranks is challenged by users of cladistics ; for example, the mere 10 ranks traditionally used between animal families (governed by the International Code of Zoological Nomenclature (ICZN)) and animal phyla (usually the highest relevant rank in taxonomic work) often cannot adequately represent the evolutionary history as more about a lineage's phylogeny becomes known. In addition,
84-427: A rank above, the prefix sub- indicates a rank below. In zoology , the prefix infra- indicates a rank below sub- . For instance, among the additional ranks of class are superclass, subclass and infraclass. Rank is relative, and restricted to a particular systematic schema. For example, liverworts have been grouped, in various systems of classification, as a family, order, class, or division (phylum). The use of
105-529: A similar appearance as a result of convergent evolution or even mimicry . In addition, there can be morphological differences within a species, such as in Apoica flavissima where queens are significantly smaller than workers. A further problem with relying on morphological data is that what may appear morphologically to be two distinct species may in fact be shown by DNA analysis to be a single species. The significance of these differences can be examined through
126-729: A taxon is given a formal scientific name , its use is then governed by one of the nomenclature codes specifying which scientific name is correct for a particular grouping. Initial attempts at classifying and ordering organisms (plants and animals) were presumably set forth in prehistoric times by hunter-gatherers, as suggested by the fairly sophisticated folk taxonomies. Much later, Aristotle, and later still, European scientists, like Magnol , Tournefort and Carl Linnaeus 's system in Systema Naturae , 10th edition (1758), , as well as an unpublished work by Bernard and Antoine Laurent de Jussieu , contributed to this field. The idea of
147-473: A unit-based system of biological classification was first made widely available in 1805 in the introduction of Jean-Baptiste Lamarck 's Flore françoise , and Augustin Pyramus de Candolle 's Principes élémentaires de botanique . Lamarck set out a system for the "natural classification" of plants. Since then, systematists continue to construct accurate classifications encompassing the diversity of life; today,
168-429: A unit. Although neither is required, a taxon is usually known by a particular name and given a particular ranking , especially if and when it is accepted or becomes established. It is very common, however, for taxonomists to remain at odds over what belongs to a taxon and the criteria used for inclusion, especially in the context of rank-based (" Linnaean ") nomenclature (much less so under phylogenetic nomenclature ). If
189-470: Is a stub . You can help Misplaced Pages by expanding it . Morphology (biology) Morphology in biology is the study of the form and structure of organisms and their specific structural features. This includes aspects of the outward appearance (shape, structure, color, pattern, size), i.e. external morphology (or eidonomy ), as well as the form and structure of internal parts like bones and organs , i.e. internal morphology (or anatomy ). This
210-569: Is found in exposed test organisms where higher doses or concentrations resulted in an adverse effect. The NOAEL level may be used in the process of establishing a dose-response relationship , a fundamental step in most risk assessment methodologies. The NOAEL is also known as NOEL (no-observed-effect level) as well as NEC (no-effect concentration) and NOEC (no-observed-effect concentration). The United States Environmental Protection Agency defines NOAEL as 'an exposure level at which there are no statistically or biologically significant increases in
231-559: Is in contrast to physiology , which deals primarily with function. Morphology is a branch of life science dealing with the study of the gross structure of an organism or taxon and its component parts. The etymology of the word "morphology" is from the Ancient Greek μορφή ( morphḗ ), meaning "form", and λόγος ( lógos ), meaning "word, study, research". While the concept of form in biology, opposed to function , dates back to Aristotle (see Aristotle's biology ),
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#1732790331712252-485: Is said to exemplify the two major deviations in biological thinking at the time – whether animal structure was due to function or evolution. Most taxa differ morphologically from other taxa. Typically, closely related taxa differ much less than more distantly related ones, but there are exceptions to this. Cryptic species are species which look very similar, or perhaps even outwardly identical, but are reproductively isolated. Conversely, sometimes unrelated taxa acquire
273-400: Is the level where there are no side-effects . It either does not provide the effects of drug with respect to duration and dose, or it does not address the interpretation of risk based on toxicologically relevant effects. In toxicology it is specifically the highest tested dose or concentration of a substance (i.e. a drug or chemical) or agent (e.g. radiation), at which no such adverse effect
294-525: The International Code of Zoological Nomenclature (1999) defines a A taxon can be assigned a taxonomic rank , usually (but not necessarily) when it is given a formal name. " Phylum " applies formally to any biological domain , but traditionally it was always used for animals, whereas "division" was traditionally often used for plants , fungi , etc. A prefix is used to indicate a ranking of lesser importance. The prefix super- indicates
315-567: The class rank is quite often not an evolutionary but a phenetic or paraphyletic group and as opposed to those ranks governed by the ICZN (family-level, genus-level and species -level taxa), can usually not be made monophyletic by exchanging the taxa contained therein. This has given rise to phylogenetic taxonomy and the ongoing development of the PhyloCode , which has been proposed as a new alternative to replace Linnean classification and govern
336-469: The field of morphology was developed by Johann Wolfgang von Goethe (1790) and independently by the German anatomist and physiologist Karl Friedrich Burdach (1800). Among other important theorists of morphology are Lorenz Oken , Georges Cuvier , Étienne Geoffroy Saint-Hilaire , Richard Owen , Carl Gegenbaur and Ernst Haeckel . In 1830, Cuvier and Saint-Hilaire engaged in a famous debate , which
357-451: The frequency or severity of adverse effects between the exposed population and its appropriate control; some effects may be produced at this level, but they are not considered as adverse, or as precursors to adverse effects. In an experiment with several NOAELs, the regulatory focus is primarily on the highest one, leading to the common usage of the term NOAEL as the highest exposure without adverse effects.' This toxicology -related article
378-469: The observation of 3-D cell morphology with both high spatial and temporal resolution. The dynamic processes of this cell morphology which are controlled by a complex system play an important role in varied important biological processes, such as immune and invasive responses. Taxa In biology , a taxon ( back-formation from taxonomy ; pl. : taxa ) is a group of one or more populations of an organism or organisms seen by taxonomists to form
399-493: The traditional Linnean (binomial) nomenclature, few propose taxa they know to be paraphyletic . An example of a long-established taxon that is not also a clade is the class Reptilia , the reptiles; birds and mammals are the descendants of animals traditionally classed as reptiles, but neither is included in the Reptilia (birds are traditionally placed in the class Aves , and mammals in the class Mammalia ). The term taxon
420-576: The use of allometric engineering in which one or both species are manipulated to phenocopy the other species. A step relevant to the evaluation of morphology between traits/features within species, includes an assessment of the terms: homology and homoplasy . Homology between features indicates that those features have been derived from a common ancestor. Alternatively, homoplasy between features describes those that can resemble each other, but derive independently via parallel or convergent evolution . The invention and development of microscopy enabled
441-598: Was first used in 1926 by Adolf Meyer-Abich for animal groups, as a back-formation from the word taxonomy ; the word taxonomy had been coined a century before from the Greek components τάξις ( táxis ), meaning "arrangement", and νόμος ( nómos ), meaning " method ". For plants, it was proposed by Herman Johannes Lam in 1948, and it was adopted at the VII International Botanical Congress , held in 1950. The glossary of
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