124-516: Pitié-Salpêtrière University Hospital ( French : Hôpital universitaire de la Pitié-Salpêtrière , IPA: [opital ynivɛʁsitɛːʁ də la pitje salpɛtʁijɛʁ] ) is a charitable hospital in the 13th arrondissement of Paris . It is part of the AP-HP Sorbonne University Hospital Group and a teaching hospital of Sorbonne University . The Salpêtrière was originally a gunpowder factory ( saltpeter being
248-654: A Morpholino antisense oligo, has been approved in the United States for the treatment of mutations amenable to dystrophin exon 51 skipping. The US approval has been controversial as eteplirsen failed to establish a clinical benefit; it has been refused approval by the European Medicines Agency. The medication ataluren (Translarna) is approved for use in the European Union. The antisense oligonucleotide golodirsen (Vyondys 53)
372-490: A 1% risk of miscarriage. Amniocentesis can be done after 15 weeks, and has a 0.5% risk of miscarriage. Non invasive prenatal testing can be done around 10–12 weeks. Another option in the case of unclear genetic test results is fetal muscle biopsy. No cure for Duchenne muscular dystrophy is known. Treatment is generally aimed at controlling symptoms to maximize the quality of life which can be measured using specific questionnaires, and include: The medication eteplirsen ,
496-744: A French official to teachers in the department of Finistère , in western Brittany, included the following: "And remember, Gents: you were given your position in order to kill the Breton language". The prefect of Basses-Pyrénées in the French Basque Country wrote in 1846: "Our schools in the Basque Country are particularly meant to replace the Basque language with French..." Students were taught that their ancestral languages were inferior and they should be ashamed of them; this process
620-601: A car crash in 1997; and French bicycle racer Laurent Fignon in 2010, from the metastatic spread of lung cancer (which coincidentally happened exactly thirteen years after Diana’s death in the same hospital). The Brain and Spine Institute, now called Institut du Cerveau (ICM) or the Paris Brain Institute, has been located in the hospital since it was established in September 2010. Chapelle de la Salpêtrière (Hospital Chapel), at n° 47 Boulevard de l'Hôpital
744-424: A carrier mother, in those who are missing an X chromosome, or those who have an inactivated X chromosome (the most common of the rare reasons). The daughter of a carrier mother and an affected father will be affected or a carrier with equal probability, as she will always inherit the affected X-chromosome from her father and has a 50% chance of also inheriting the affected X-chromosome from her mother. Disruption of
868-432: A child tries to arise from lying on his stomach, he compensates for pelvic muscle weakness through use of the upper extremities: first by rising to stand on his arms and knees, and then "walking" his hands up his legs to stand upright. Another characteristic sign of Duchenne muscular dystrophy is pseudohypertrophy (enlarging) of the muscles of the tongue, calves, buttocks, and shoulders (around age 4 or 5). The muscle tissue
992-431: A comprehensive academic study entitled "The World's 10 most influential languages". In the article, Weber ranked French as, after English, the second-most influential language of the world, ahead of Spanish. His criteria were the numbers of native speakers, the number of secondary speakers (especially high for French among fellow world languages), the number of countries using the language and their respective populations,
1116-584: A constituent of gunpowder ), but in 1656 at the direction of Louis XIV , it was converted into a hospice for the poor women of Paris as part of the General Hospital of Paris . This main hospice was for women who were learning disabled, mentally ill, or epileptic , as well as poor. In 1657 it was incorporated with the hospice of the Pitié designed specifically for beggars' children and orphans. Sheets for hospice and military clothing were produced there by
1240-555: A foreign language. Due to the rise of French in Africa, the total French-speaking population worldwide is expected to reach 700 million people in 2050. French is the fastest growing language on the continent (in terms of either official or foreign languages). French is increasingly being spoken as a native language in Francophone Africa, especially in regions like Ivory Coast , Cameroon , Gabon, Madagascar , and
1364-644: A gene editing method to correct a mutation that leads to Duchenne muscular dystrophy (DMD). Researchers used a technique called CRISPR/Cas9-mediated genome editing , which can precisely remove a mutation in the dystrophin gene in DNA, allowing the body's DNA repair mechanisms to replace it with a normal copy of the gene. Genome editing through the CRISPR/Cas9 system is not currently feasible in humans. However, it may be possible, through advancements in technology, to use this technique to develop therapies for DMD in
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#17327809176921488-538: A male disorder ("traumatic hysteria"), he is popularly remembered for his demonstrations with Louise Augustine Gleizes and Marie Wittman . Charcot had also absorbed much from Duchenne (to whom he often referred as " mon maître, Duchenne ") and his teaching activities on the Salpêtrière's wards helped to elucidate the natural history of many diseases including neurosyphilis , epilepsy , and stroke . In his discussion of paralysis agitans , Charcot drew attention to
1612-474: A median life expectancy of 27–31 years. However, with comprehensive care, some individuals may live into their 30s or 40s. Duchenne muscular dystrophy is considerably rarer in females, occurring in approximately one in 50,000,000 live female births. Duchenne muscular dystrophy causes progressive muscle weakness due to muscle fiber disarray, death, and replacement with connective tissue or fat. The voluntary muscles are affected first, especially those of
1736-705: A period of prosperity and prominence among European nations. Richelieu established the Académie française to protect the French language. By the early 1800s, Parisian French had become the primary language of the aristocracy in France. Near the beginning of the 19th century, the French government began to pursue policies with the end goal of eradicating the many minorities and regional languages ( patois ) spoken in France. This began in 1794 with Henri Grégoire 's "Report on
1860-500: A primary state of dyslipidemia in patients. Duchenne muscular dystrophy is the most common type of muscular dystrophy; it affects about one in 5,000 males at birth. Duchenne muscular dystrophy has an incidence of one in 3,600 male infants. In the US, a 2010 study showed a higher amount of those with Duchenne muscular dystrophy age ranging from 5 to 54 who are Hispanic compared to non-Hispanic Whites, and non-Hispanic Blacks. The disease
1984-494: A relic of the old nominal case system of Latin longer than most other Romance languages (with the notable exception of Romanian which still currently maintains a case distinction), differentiating between an oblique case and a nominative case. The phonology was characterized by heavy syllabic stress, which led to the emergence of various complicated diphthongs such as -eau which would later be leveled to monophthongs. The earliest evidence of what became Old French can be seen in
2108-619: A result of French and Belgian colonialism from the 16th century onward, French was introduced to new territories in the Americas, Africa, and Asia. French has a long history as an international language of literature and scientific standards and is a primary or second language of many international organisations including the United Nations , the European Union, the North Atlantic Treaty Organization ,
2232-547: A variant of Canadian French , is spoken in parts of New England . Missouri French was historically spoken in Missouri and Illinois (formerly known as Upper Louisiana ), but is nearly extinct today. French also survived in isolated pockets along the Gulf Coast of what was previously French Lower Louisiana , such as Mon Louis Island , Alabama and DeLisle, Mississippi (the latter only being discovered by linguists in
2356-457: A working language along with English and German ; in some institutions, French is the sole working language (e.g. at the Court of Justice of the European Union ). French is also the 16th most natively spoken language in the world, the sixth most spoken language by total number of speakers , and is among the top five most studied languages worldwide, with about 120 million learners as of 2017. As
2480-437: Is 95%, and in the French collectivity of Wallis and Futuna , it is 84%. In French Polynesia and to a lesser extent Wallis and Futuna, where oral and written knowledge of the French language has become almost universal (95% and 84% respectively), French increasingly tends to displace the native Polynesian languages as the language most spoken at home. In French Polynesia, the percentage of the population who reported that French
2604-472: Is a widespread second language among the Lebanese people , and is taught in many schools along with Arabic and English. French is used on Lebanese pound banknotes, on road signs, on Lebanese license plates , and on official buildings (alongside Arabic). Today, French and English are secondary languages of Lebanon , with about 40% of the population being Francophone and 40% Anglophone. The use of English
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#17327809176922728-489: Is also a working language in nonprofit organisations such as the Red Cross (alongside English, German, Spanish, Portuguese, Arabic and Russian), Amnesty International (alongside 32 other languages of which English is the most used, followed by Spanish, Portuguese, German, and Italian), Médecins sans Frontières (used alongside English, Spanish, Portuguese and Arabic), and Médecins du Monde (used alongside English). Given
2852-519: Is amenable to exon 53 skipping. Casimersen (Amondys 45) was approved for medical use in the United States in February 2021, and it is the first FDA-approved targeted treatment for people who have a confirmed mutation of the Duchenne muscular dystrophy gene that is amenable to exon 45 skipping. Comprehensive multidisciplinary care guidelines for Duchenne muscular dystrophy have been developed by
2976-464: Is amenable to exon 53 skipping. Developed by Nippon Shinyaku and the National Center of Neurology and Psychiatry (NCNP), viltolarsen's pre-clinical development was supported by pioneering work from Toshifumi Yokota and colleagues. It is the second approved targeted treatment for people with this type of mutation in the United States. Approximately 8% of people with DMD have a mutation that
3100-480: Is caused by mutations and/or deletions in any of the 79 exons encoding the large dystrophin protein , which is essential for maintaining the muscle fiber's cell membrane integrity. The disorder follows an X-linked recessive inheritance pattern, with approximately two-thirds of cases inherited from the mother and one-third resulting from a new mutation . Diagnosis can frequently be made at birth through genetic testing , and elevated creatine kinase levels in
3224-713: Is commemorated in the myopathies which he described, as well as in his 1862 masterpiece, the Mécanisme de la physionomie humaine , much consulted by Charles Darwin in the preparation of his Expression of the Emotions in Man and Animals (1872). Duchenne's last major work (published in 1867) was a study of animal locomotion. He was never elected to the Academy of Sciences. Later, when Jean-Martin Charcot (1825–1893) took over
3348-424: Is common, seen in half of 18-year-olds. The development of congestive heart failure or arrhythmia (irregular heartbeat) is only occasional. In late stages of the disease, respiratory impairment and swallowing impairment can occur, which can result in pneumonia . A classic sign of Duchenne muscular dystrophy is trouble getting up from lying or sitting position, as manifested by a positive Gowers's sign . When
3472-652: Is enacted only in New Brunswick, where about one third of the population is Francophone. French is also an official language of all of the territories ( Northwest Territories , Nunavut , and Yukon ). Out of the three, Yukon has the most French speakers, making up just under 4% of the population. Furthermore, while French is not an official language in Ontario , the French Language Services Act ensures that provincial services are available in
3596-427: Is eventually replaced by fat and connective tissue, hence the term pseudohypertrophy. Muscle fiber deformities and muscle contractures of Achilles tendon and hamstrings can occur, which impair functionality because the muscle fibers shorten and fibrose in connective tissue . Skeletal deformities can occur, such as lumbar hyperlordosis , scoliosis , anterior pelvic tilt , and chest deformities. Lumbar hyperlordosis
3720-672: Is functional even though it is shorter than normal dystrophin. In 1990 England et al. noticed that a patient with mild Becker muscular dystrophy was lacking 46% of his coding region for dystrophin. This functional, yet truncated, form of dystrophin gave rise to the notion that shorter dystrophin can still be therapeutically beneficial. Concurrently, Kole et al. had modified splicing by targeting pre-mRNA with antisense oligonucleotides (AONs). Kole demonstrated success using splice-targeted AONs to correct missplicing in cells removed from beta-thalassemia patients Wilton's group tested exon skipping for muscular dystrophy. Researchers are working on
3844-563: Is growing in the business and media environment. Out of about 900,000 students, about 500,000 are enrolled in Francophone schools, public or private, in which the teaching of mathematics and scientific subjects is provided in French. Actual usage of French varies depending on the region and social status. One-third of high school students educated in French go on to pursue higher education in English-speaking institutions. English
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3968-404: Is known as Old French. The period of Old French spanned between the 8th and 14th centuries. Old French shared many characteristics with Latin. For example, Old French made use of different possible word orders just as Latin did because it had a case system that retained the difference between nominative subjects and oblique non-subjects . The period is marked by a heavy superstrate influence from
4092-469: Is often considered to be a useful skill by business owners in the United Kingdom; a 2014 study found that 50% of British managers considered French to be a valuable asset for their business, thus ranking French as the most sought-after foreign language there, ahead of German (49%) and Spanish (44%). MIT economist Albert Saiz calculated a 2.3% premium for those who have French as a foreign language in
4216-426: Is one of the masterpieces of Libéral Bruant , architect of Les Invalides . It was built around 1675, on the model of a Greek cross and has four central chapels each capable of holding a congregation of some 1,000 people. Its central octagonal cupola is illuminated by picture windows in circular arcs. In the place in front of the main entrance to the hospital, there is a large bronze monument to Philippe Pinel , who
4340-828: Is one of the official languages of such major international and regional courts, tribunals, and dispute-settlement bodies as the African Court on Human and Peoples' Rights , the Caribbean Court of Justice , the Court of Justice for the Economic Community of West African States , the Inter-American Court of Human Rights , the International Court of Justice , the International Criminal Tribunal for
4464-451: Is responsible for connecting the actin cytoskeleton of each muscle fiber to the underlying basal lamina ( extracellular matrix ), through a protein complex containing many subunits. The absence of dystrophin permits excess calcium to penetrate the sarcolemma (the muscle cell membrane). Duchenne muscular dystrophy is extremely rare in females (about 1 in 50,000,000 female births). It can occur in females with an affected father and
4588-425: Is targeted to skip exon 51. "As an example, skipping exon 51 restores the reading frame of ~ 15% of all the boys with deletions. It has been suggested that by having 10 AONs to skip 10 different exons it would be possible to deal with more than 70% of all DMD boys with deletions." This represents about 1.5% of cases. People with Becker's muscular dystrophy , which is milder than DMD, have a form of dystrophin which
4712-639: Is taught in universities around the world, and is one of the world's most influential languages because of its wide use in the worlds of journalism, jurisprudence , education, and diplomacy. In diplomacy, French is one of the six official languages of the United Nations (and one of the UN Secretariat 's only two working languages ), one of twenty official and three procedural languages of the European Union , an official language of NATO ,
4836-553: Is the language of business and communication, with French being an element of social distinction, chosen for its emotional value. French is an official language of the Pacific Island nation of Vanuatu , where 31% of the population was estimated to speak it in 2023. In the French special collectivity of New Caledonia , 97% of the population can speak, read and write French while in French Polynesia this figure
4960-483: Is the native language of about 23% of the Swiss population, and is spoken by 50% of the population. Along with Luxembourgish and German, French is one of the three official languages of Luxembourg , where it is generally the preferred language of business as well as of the different public administrations. It is also the official language of Monaco . At a regional level, French is acknowledged as an official language in
5084-492: Is the second-most spoken language (after English) in the states of Maine and New Hampshire . In Louisiana , it is tied with Spanish for second-most spoken if Louisiana French and all creoles such as Haitian are included. French is the third most spoken language (after English and Spanish) in the states of Connecticut , Rhode Island , and New Hampshire . Louisiana is home to many distinct French dialects, collectively known as Louisiana French . New England French , essentially
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5208-424: Is the sole official language in the province of Quebec , where some 80% of the population speak it as a native language and 95% are capable of conducting a conversation in it. Quebec is also home to the city of Montreal , which is the world's fourth-largest French-speaking city, by number of first language speakers. New Brunswick and Manitoba are the only officially bilingual provinces, though full bilingualism
5332-478: Is thought to be compensatory mechanism in response to gluteal and quadriceps muscle weakness, all of which cause altered posture and gait (e.g.: restricted hip extension). Non musculoskeletal manifestations of Duchenne muscular dystrophy occur. There is a higher risk of neurobehavioral disorders (e.g., ADHD ), learning disorders ( dyslexia ), and non-progressive weaknesses in specific cognitive skills (in particular short-term verbal memory), which are believed to be
5456-764: The Aosta Valley region of Italy where it is the first language of approximately 50% of the population, while French dialects remain spoken by minorities on the Channel Islands . It is also spoken in Andorra and is the main language after Catalan in El Pas de la Casa . The language is taught as the primary second language in the German state of Saarland , with French being taught from pre-school and over 43% of citizens being able to speak French. The majority of
5580-609: The Democratic Republic of Congo . There is not a single African French , but multiple forms that diverged through contact with various indigenous African languages . Sub-Saharan Africa is the region where the French language is most likely to expand, because of the expansion of education and rapid population growth. It is also where the language has evolved the most in recent years. Some vernacular forms of French in Africa can be difficult to understand for French speakers from other countries, but written forms of
5704-517: The Democratic Republic of the Congo . In some North African countries, though not having official status, it is also a first language among some upper classes of the population alongside indigenous languages, but only a second one among the general population. In 2015, approximately 40% of the Francophone population (including L2 and partial speakers) lived in Europe, 36% in sub-Saharan Africa and
5828-533: The European Union , French was the dominant language within all institutions until the 1990s. After several enlargements of the EU (1995, 2004), French significantly lost ground in favour of English, which is more widely spoken and taught in most EU countries. French currently remains one of the three working languages, or "procedural languages", of the EU, along with English and German. It is the second-most widely used language within EU institutions after English, but remains
5952-559: The Francien dialect is one that not only continued but also thrived during the Middle French period (14th–17th centuries). Modern French grew out of this Francien dialect. Grammatically, during the period of Middle French, noun declensions were lost and there began to be standardized rules. Robert Estienne published the first Latin-French dictionary, which included information about phonetics, etymology, and grammar. Politically,
6076-877: The International Olympic Committee , the Council of Europe , the Organisation for Economic Co-operation and Development , Organization of American States (alongside Spanish, Portuguese and English), the Eurovision Song Contest , one of eighteen official languages of the European Space Agency , World Trade Organization and the least used of the three official languages in the North American Free Trade Agreement countries. It
6200-626: The Oaths of Strasbourg and the Sequence of Saint Eulalia , while Old French literature began to be produced in the eleventh century, with major early works often focusing on the lives of saints (such as the Vie de Saint Alexis ), or wars and royal courts, notably including the Chanson de Roland , epic cycles focused on King Arthur and his court , as well as a cycle focused on William of Orange . It
6324-713: The Vulgar Latin of the Roman Empire . French evolved from Gallo-Romance , the Latin spoken in Gaul , and more specifically in Northern Gaul. Its closest relatives are the other langues d'oïl —languages historically spoken in northern France and in southern Belgium, which French ( Francien ) largely supplanted. French was also influenced by native Celtic languages of Northern Roman Gaul like Gallia Belgica and by
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#17327809176926448-775: The World Trade Organization , the International Olympic Committee , the General Conference on Weights and Measures , and the International Committee of the Red Cross . French is a Romance language (meaning that it is descended primarily from Vulgar Latin ) that evolved out of the Gallo-Romance dialects spoken in northern France. The language's early forms include Old French and Middle French . Due to Roman rule, Latin
6572-794: The blood are indicative of the condition. While there is no known cure, management strategies such as physical therapy , braces , and corrective surgery may alleviate symptoms. Assisted ventilation may be required in those with weakness of breathing muscles . Several drugs designed to address the root cause are currently available including gene therapy ( Elevidys ), and antisense drugs ( Ataluren , Eteplirsen etc.). Other medications used include glucocorticoids ( Deflazacort , Vamorolone ); calcium channel blockers ( Diltiazem ); to slow skeletal and cardiac muscle degeneration, anticonvulsants to control seizures and some muscle activity, and Histone deacetylase inhibitors ( Givinostat ) to delay damage to dying muscle cells . Various figures of
6696-409: The blood–brain barrier has been seen to be a noted feature in the development of Duchenne muscular dystrophy. Duchenne muscular dystrophy can be detected with about 95% accuracy by genetic studies performed during pregnancy. The muscle-specific isoform of the dystrophin gene is composed of 79 exons , and DNA testing ( blood test ) and analysis can usually identify the specific type of mutation of
6820-481: The chef d'hospice was Jean-Pierre Falret (1794–1870) who contributed much to our understanding of bipolar disorder and folie à deux . A regular visitor to the Salpêtrière from 1842 till his death more than thirty years later was Guillaume-Benjamin Duchenne de Boulogne (1806–1875). From humble provincial origins, a long line of seafarers from Boulogne, Duchenne became one of the outstanding medical scientists of
6944-480: The hips , pelvic area , thighs , calves . It eventually progresses to the shoulders and neck, followed by arms , respiratory muscles, and other areas. Fatigue is common. Signs usually appear before age five, and may even be observed from the moment a boy takes his first steps. There is general difficulty with motor skills , which can result in an awkward manner of walking, stepping, or running. They tend to walk on their toes , in part due to shortening of
7068-578: The mdx mouse model of Duchenne muscular dystrophy, the lack of dystrophin is associated with increased calcium levels and skeletal muscle myonecrosis. The intrinsic laryngeal muscles (ILMs) are protected and do not undergo myonecrosis. ILMs have a calcium regulation system profile suggestive of a better ability to handle calcium changes in comparison to other muscles, and this may provide a mechanistic insight for their unique pathophysiological properties. In addition, patients with Duchenne muscular dystrophy also have elevated plasma lipoprotein levels, implying
7192-474: The median survival age can reach up to 40. In rare cases, people with Duchenne muscular dystrophy have been seen to survive into their forties or early fifties, with proper positioning in wheelchairs and beds, and the use of ventilator support (via tracheostomy or mouthpiece), airway clearance, and heart medications. Early planning of the required supports for later-life care has shown greater longevity for people with Duchenne muscular dystrophy. Curiously, in
7316-626: The provinces of Quebec, Ontario, and New Brunswick); Belgium ( Wallonia and the Brussels-Capital Region ); western Switzerland (specifically the cantons forming the Romandy region); parts of Luxembourg; parts of the United States (the states of Louisiana, Maine, New Hampshire, and Vermont); Monaco; the Aosta Valley region of Italy; and various communities elsewhere. French is estimated to have about 310 million speakers, of which about 80 million are native speakers. According to
7440-427: The ( Germanic ) Frankish language of the post-Roman Frankish invaders. Today, owing to the French colonial empire , there are numerous French-based creole languages , most notably Haitian Creole . A French-speaking person or nation may be referred to as Francophone in both English and French. French is an official language in 27 countries , as well as one of the most geographically widespread languages in
7564-555: The 1817 description by James Parkinson , and suggested it be renamed Parkinson's disease . In 1882, with Charcot's encouragement, Albert Londe created a photographic department in the Salpêtriėre, producing, in collaboration with Georges Gilles de la Tourette , the Nouvelle Iconographie de la Salpêtrière of 1888. Students came from across the world to witness Charcot's clinical demonstrations: among them – in 1885 –
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#17327809176927688-660: The 1929 autobiographical memoir – The Story of San Michele – by the Swedish physician Axel Munthe , whose early idolatry of Charcot gave way to a kind of obsessive antagonism. The Hôpital de la Pitié, founded about 1612, was moved next to the Salpêtrière in 1911 and fused with it in 1964 to form the Groupe Hospitalier Pitié-Salpêtrière. The Pitié-Salpêtrière is now a general teaching hospital with departments focusing on most major medical specialties. Numerous personalities have been treated at
7812-506: The 1990s) but these varieties are severely endangered or presumed extinct. French is one of two official languages in Haiti alongside Haitian Creole . It is the principal language of education, administration, business, and public signage and is spoken by all educated Haitians. It is also used for ceremonial events such as weddings, graduations, and church masses. The vast majority of the population speaks Haitian Creole as their first language;
7936-773: The 20th century, when it was replaced by English as the United States became the dominant global power following the Second World War . Stanley Meisler of the Los Angeles Times said that the fact that the Treaty of Versailles was written in English as well as French was the "first diplomatic blow" against the language. During the Grand Siècle (17th century), France, under the rule of powerful leaders such as Cardinal Richelieu and Louis XIV , enjoyed
8060-402: The Achilles tendon, and because it compensates for knee extensor weakness. Falls can be frequent. It becomes increasingly difficult for the boy to walk. His ability to walk usually disintegrates completely before age 13. Most men affected with Duchenne muscular dystrophy become essentially "paralyzed from the neck down" by the age of 21. Cardiomyopathy , particularly dilated cardiomyopathy ,
8184-510: The Canadian capital, is also effectively bilingual, as it has a large population of federal government workers, who are required to offer services in both French and English, and is just across the river from the Quebecois city of Gatineau . According to the United States Census Bureau (2011), French is the fourth most spoken language in the United States after English, Spanish, and Chinese, when all forms of French are considered together and all dialects of Chinese are similarly combined. French
8308-614: The Caribbean that are collectively referred to as the French West Indies , namely Guadeloupe , Saint Barthélemy , Saint Martin , and Martinique . French is the official language of both French Guiana on the South American continent, and of Saint Pierre and Miquelon , an archipelago off the coast of Newfoundland in North America. French was the official language of the colony of French Indochina , comprising modern-day Vietnam , Laos , and Cambodia . It continues to be an administrative language in Laos and Cambodia, although its influence has waned in recent decades. In colonial Vietnam,
8432-408: The Empire, this local elite had been slowly abandoning Gaulish entirely, but the rural and lower class populations remained Gaulish speakers who could sometimes also speak Latin or Greek. The final language shift from Gaulish to Vulgar Latin among rural and lower class populations occurred later, when both they and the incoming Frankish ruler/military class adopted the Gallo-Roman Vulgar Latin speech of
8556-416: The Germanic Frankish language , which non-exhaustively included the use in upper-class speech and higher registers of V2 word order , a large percentage of the vocabulary (now at around 15% of modern French vocabulary ) including the impersonal singular pronoun on (a calque of Germanic man ), and the name of the language itself. Up until its later stages, Old French , alongside Old Occitan , maintained
8680-410: The Indian Ocean, 15% in North Africa and the Middle East, 8% in the Americas, and 1% in Asia and Oceania. French is the second most widely spoken mother tongue in the European Union . Of Europeans who speak other languages natively, approximately one-fifth are able to speak French as a second language. French is the second most taught foreign language in the EU. All institutions of the EU use French as
8804-402: The OIF, approximately 321 million people worldwide are "able to speak the language" as of 2022, without specifying the criteria for this estimation or whom it encompasses. In Francophone Africa, it is spoken mainly as a second language. However it has also become a native language in a number of urban areas, especially in regions like Ivory Coast , Cameroon , Gabon, Madagascar , and
8928-543: The Pitié-Salpétrière hosted notable doctors, among others: 48°50′13″N 2°21′54″E / 48.837°N 2.365°E / 48.837; 2.365 French language French ( français [fʁɑ̃sɛ] or langue française [lɑ̃ɡ fʁɑ̃sɛːz] ) is a Romance language of the Indo-European family . Like all other Romance languages, it descended from
9052-603: The Salpêtrière, including Michael Schumacher , Ronaldo , Prince Rainier of Monaco , Alain Delon , Gérard Depardieu , and Valérie Trierweiler . Former president Jacques Chirac had a pacemaker fitted at the Salpêtrière in 2008. Celebrities have also died at the Pitié-Salpêtrière, including the singer Josephine Baker in 1975, following a cerebral haemorrhage; philosopher Michel Foucault in 1984 due to AIDS-related complications; Diana, Princess of Wales following
9176-603: The US Centers for Disease Control and Prevention , and were published in 2010. An update was published in 2018. Delandistrogene moxeparvovec (Elevidys) is a gene therapy that in June 2023 received United States FDA accelerated approval for treatment of four and five-year-old children. In March 2024, the US Food and Drug Administration (FDA) granted approval for givinostat (Duvyzat), an oral medication, to be used in
9300-429: The children. Between 1663 and 1673, 240 of the women at the Pitié-Salpêtrière hospice were sent on a mission to populate the Americas and help build New France . They were in the total number of 768 young women recruited during the ten-year period to become known as the " King's Daughters ". The Salpêtrière was much admired for the architectural designs of Libéral Bruant with the support of Louis Le Vau . Its conversion
9424-560: The condition, and muscle biopsy is not required as often to confirm the presence of Duchenne muscular dystrophy. A prenatal test can be considered when the mother is a known or suspected carrier. Prior to invasive testing, determination of the fetal sex is important; while males are sometimes affected by this X-linked disease, female Duchenne muscular dystrophy is extremely rare. This can be achieved by ultrasound scan at 16 weeks or more recently by free fetal DNA (cffDNA) testing. Chorion villus sampling (CVS) can be done at 11–14 weeks, and has
9548-468: The country near French-speaking Quebec, however, it is the foreign language more commonly taught. Vowel phonemes in French Duchenne muscular dystrophy Duchenne muscular dystrophy ( DMD ) is a severe type of muscular dystrophy predominantly affecting boys. The onset of muscle weakness typically begins around age four, with rapid progression. Initially, muscle loss occurs in
9672-519: The demographic prospects of the French-speaking nations of Africa, researcher Pascal-Emmanuel Gobry wrote in 2014 that French "could be the language of the future". However, some African countries such as Algeria intermittently attempted to eradicate the use of French, and as of 2024 it was removed as an official language in Mali and Burkina Faso . Significant as a judicial language, French
9796-520: The department, the Salpêtrière became celebrated as a neuropsychiatric teaching facility, represented on canvas in 1887 by A Clinical Lesson at the Salpêtrière by André Brouillet . In his lectures and demonstrations, the leçons du mardi , Charcot systematized the neurological examination, did much to map out the territory of modern clinical neurology and, in a personal enthusiasm, explored its interface with psychological distress as represented in hysteria . Although Charcot insisted that hysteria could be
9920-463: The disease. Duchenne muscular dystrophy is a rare progressive disease which eventually affects all voluntary muscles and involves the heart and breathing muscles in later stages. Life expectancy is estimated to be around 25–26, but this varies. People born with Duchenne muscular dystrophy after 1990 have a median life expectancy of approximately 28–30. With excellent medical care, affected men often live into their 30s. The oldest surviving person in
10044-432: The dystrophin gene to be skipped when it is transcribed to RNA for protein production, permitting a still-truncated but more functional version of the protein to be produced. It is also known as nonsense suppression therapy. Two kinds of antisense oligos, 2'-O-methyl phosphorothioate oligos (like Drisapersen ) and Morpholino oligos (like eteplirsen ), have tentative evidence of benefit and are being studied. Eteplirsen
10168-448: The economic power of the countries using the language, the number of major areas in which the language is used, and the linguistic prestige associated with the mastery of the language (Weber highlighted that French in particular enjoys considerable linguistic prestige). In a 2008 reassessment of his article, Weber concluded that his findings were still correct since "the situation among the top ten remains unchanged." Knowledge of French
10292-594: The elites primarily spoke French, while many servants who worked in French households spoke a French pidgin known as " Tây Bồi " (now extinct). After French rule ended, South Vietnam continued to use French in administration, education, and trade. However, since the Fall of Saigon and the opening of a unified Vietnam's economy, French has gradually been effectively displaced as the first foreign language of choice by English in Vietnam. Nevertheless, it continues to be taught as
10416-512: The exon or exons that are affected. DNA testing confirms the diagnosis in most cases. If DNA testing fails to find the mutation, a muscle biopsy test may be performed. A small sample of muscle tissue is extracted using a biopsy needle. The key tests performed on the biopsy sample for Duchenne muscular dystrophy are immunohistochemistry , immunocytochemistry , and immunoblotting for dystrophin, and should be interpreted by an experienced neuromuscular pathologist. These tests provide information on
10540-516: The first government authority to adopt Modern French as official was the Aosta Valley in 1536, while the Ordinance of Villers-Cotterêts (1539) named French the language of law in the Kingdom of France . During the 17th century, French replaced Latin as the most important language of diplomacy and international relations ( lingua franca ). It retained this role until approximately the middle of
10664-915: The former Yugoslavia , International Criminal Tribunal for Rwanda , the International Tribunal for the Law of the Sea the International Criminal Court and the World Trade Organization Appellate Body . It is the sole internal working language of the Court of Justice of the European Union , and makes with English the European Court of Human Rights 's two working languages. In 1997, George Weber published, in Language Today ,
10788-672: The future. In 2007, researchers did the world's first clinical (viral-mediated) gene therapy trial for Duchenne MD. Biostrophin is a delivery vector for gene therapy in the treatment of Duchenne muscular dystrophy and Becker muscular dystrophy . Several medications designed to address the root cause are under development, including gene therapy and antisense drugs . Other medications used include corticosteroids to slow muscle degeneration. Physical therapy , orthopedic braces , and corrective surgery may help with some symptoms while assisted ventilation may be required in those with weakness of breathing muscles . Outcomes depend on
10912-829: The gender of the corresponding word in Gaulish. The estimated number of French words that can be attributed to Gaulish is placed at 154 by the Petit Robert , which is often viewed as representing standardized French, while if non-standard dialects are included, the number increases to 240. Known Gaulish loans are skewed toward certain semantic fields, such as plant life ( chêne , bille , etc.), animals ( mouton , cheval , etc.), nature ( boue , etc.), domestic activities (ex. berceau ), farming and rural units of measure ( arpent , lieue , borne , boisseau ), weapons, and products traded regionally rather than further afield. This semantic distribution has been attributed to peasants being
11036-454: The language are very closely related to those of the rest of the French-speaking world. French is the second most commonly spoken language in Canada and one of two federal official languages alongside English. As of the 2021 Canadian census , it was the native language of 7.7 million people (21% of the population) and the second language of 2.9 million (8% of the population). French
11160-479: The language, although it has now given way to Tamil and English. A former French mandate , Lebanon designates Arabic as the sole official language, while a special law regulates cases when French can be publicly used. Article 11 of Lebanon's Constitution states that "Arabic is the official national language. A law determines the cases in which the French language is to be used". The French language in Lebanon
11284-612: The language. The Act applies to areas of the province where there are significant Francophone communities, namely Eastern Ontario and Northern Ontario . Elsewhere, sizable French-speaking minorities are found in southern Manitoba, Nova Scotia , Prince Edward Island and the Port au Port Peninsula in Newfoundland and Labrador, where the unique Newfoundland French dialect was historically spoken. Smaller pockets of French speakers exist in all other provinces. The Ontarian city of Ottawa ,
11408-479: The last to hold onto Gaulish. The beginning of French in Gaul was greatly influenced by Germanic invasions into the country. These invasions had the greatest impact on the northern part of the country and on the language there. A language divide began to grow across the country. The population in the north spoke langue d'oïl while the population in the south spoke langue d'oc . Langue d'oïl grew into what
11532-420: The necessity and means to annihilate the patois and to universalize the use of the French language". When public education was made compulsory , only French was taught and the use of any other ( patois ) language was punished. The goals of the public school system were made especially clear to the French-speaking teachers sent to teach students in regions such as Occitania and Brittany . Instructions given by
11656-474: The nineteenth century. Though he never held a senior appointment in the hospital, Duchenne nevertheless made meticulous observations on neurological patients, employing a wide range of innovative diagnostic techniques. Duchenne's clinical science stood at the technical junction of electricity, photography and psychology, as recorded in his much admired De l'électrisation localisée with its associated atlas Album de photographies pathologiques (1855, 1862). His name
11780-441: The occurrence of Duchenne muscular dystrophy are reported. One source reports that it affects about one in 3,500 to 6,000 males at birth. Another source reports Duchenne muscular dystrophy being a rare disease and having an occurrence of 7.1 per 100,000 male births. A number of sources referenced in this article indicate an occurrence of 6 per 100,000. Duchenne muscular dystrophy is the most common type of muscular dystrophy, with
11904-534: The other main foreign language in the Vietnamese educational system and is regarded as a cultural language. All three countries are full members of La Francophonie (OIF). French was the official language of French India , consisting of the geographically separate enclaves referred to as Puducherry . It continued to be an official language of the territory even after its cession to India in 1956 until 1965. A small number of older locals still retain knowledge of
12028-471: The preferred language of certain institutions or administrations such as the Court of Justice of the European Union , where it is the sole internal working language, or the Directorate-General for Agriculture . Since 2016, Brexit has rekindled discussions on whether or not French should again hold greater role within the institutions of the European Union. A leading world language , French
12152-411: The presence or absence of the protein. Absence of the protein is a positive test for Duchenne muscular dystrophy. Where dystrophin is present, the tests indicate the amount and molecular size of dystrophin, helping to distinguish Duchenne muscular dystrophy from milder dystrophinopathy phenotypes. Over the past several years, DNA tests have been developed that detect more of the many mutations that cause
12276-471: The rest largely speak French as a first language. As a French Creole language , Haitian Creole draws the large majority of its vocabulary from French, with influences from West African languages, as well as several European languages. It is closely related to Louisiana Creole and the creole from the Lesser Antilles . French is the sole official language of all the overseas territories of France in
12400-441: The result of inadequate dystrophin in the brain. Duchenne muscular dystrophy is caused by a mutation of the dystrophin gene, located on the short arm of the X chromosome ( locus Xp21) that codes for dystrophin protein. Mutations can either be inherited or occur spontaneously during germline transmission, causing a large reduction or absence of dystrophin, a protein that provides structural integrity in muscle cells. Dystrophin
12524-615: The sick were sent to the Hôtel-Dieu hospital. During the September massacres of 1792, the Salpêtrière was stormed on the nights of September 3/4 by a mob from the impoverished working-class district of the Faubourg Saint-Marcel, with the avowed intention of releasing the detained prisoners: 134 of the prostitutes were released; twenty-five madwomen were less fortunate and were dragged, some still in their chains, into
12648-568: The streets and murdered. At the very end of the 18th century, the early humanitarian reforms in the treatment of the mentally ill were initiated here by Philippe Pinel (1745–1826), friend of the Encyclopédistes . The iconic image of Pinel as the liberator of the insane was created in 1876 by Tony Robert-Fleury and Pinel's sculptural monument stands before the main entrance in Place Marie-Curie, Boulevard de L'Hôpital. Pinel
12772-456: The thighs and pelvis , extending to the arms, which can lead to difficulties in standing up. By the age of 12, most individuals with Duchenne muscular dystrophy are unable to walk. Affected muscles may appear larger due to an increase in fat content, and scoliosis is common. Some individuals may experience intellectual disability , and females carrying a single copy of the mutated gene may show mild symptoms. Duchenne muscular dystrophy
12896-466: The total number of French speakers will reach approximately 500 million in 2025 and 650 million by 2050, largely due to rapid population growth in sub-Saharan Africa . OIF estimates 700 million French speakers by 2050, 80% of whom will be in Africa. In a study published in March 2014 by Forbes , the investment bank Natixis said that French could become the world's most spoken language by 2050. In
13020-453: The treatment of Duchenne muscular dystrophy in people aged six years and older. Givinostat is the first nonsteroidal drug to receive FDA approval for the treatment of all genetic variants of Duchenne muscular dystrophy. Functioning as a histone deacetylase ( Histone deacetylase (HDAC) inhibitor, givinostat operates by targeting pathogenic processes within the body, ultimately leading to a reduction in inflammation and muscle loss associated with
13144-679: The two official languages—along with Dutch —of the Brussels-Capital Region , where it is spoken by the majority of the population (approx. 80%), often as their primary language. French is one of the four official languages of Switzerland, along with German, Italian, and Romansh , and is spoken in the western part of Switzerland, called Romandy , of which Geneva is the largest city. The language divisions in Switzerland do not coincide with political subdivisions, and some cantons have bilingual status: for example, cities such as Biel/Bienne and cantons such as Valais , Fribourg and Bern . French
13268-508: The urban intellectual elite. The Gaulish language likely survived into the sixth century in France despite considerable Romanization . Coexisting with Latin, Gaulish helped shape the Vulgar Latin dialects that developed into French contributing loanwords and calques (including oui , the word for "yes"), sound changes shaped by Gaulish influence, and influences in conjugation and word order. Recent computational studies suggest that early gender shifts may have been motivated by
13392-485: The use of French in official government publications, public education except in specific cases, and legal contracts; advertisements must bear a translation of foreign words. In Belgium, French is an official language at the federal level along with Dutch and German. At the regional level, French is the sole official language of Wallonia (excluding a part of the East Cantons , which are German-speaking ) and one of
13516-536: The workplace. In 2011, Bloomberg Businessweek ranked French the third most useful language for business, after English and Standard Mandarin Chinese . In English-speaking Canada, the United Kingdom, and Ireland, French is the first foreign language taught and in number of pupils is far ahead of other languages. In the United States, French is the second-most commonly taught foreign language in schools and universities, although well behind Spanish. In some areas of
13640-418: The world with the disease is 60 years old. The most common direct cause of death in people with Duchenne muscular dystrophy is respiratory failure . Complications from treatment, such as mechanical ventilation and tracheotomy procedures, are also a concern. The next leading cause of death is cardiac-related conditions such as heart failure brought on by dilated cardiomyopathy . With respiratory assistance,
13764-402: The world's French-speaking population lives in Africa. According to a 2023 estimate from the Organisation internationale de la Francophonie , an estimated 167 million African people spread across 35 countries and territories can speak French as either a first or a second language . This number does not include the people living in non-Francophone African countries who have learned French as
13888-503: The world, with about 50 countries and territories having it as a de jure or de facto official, administrative, or cultural language. Most of these countries are members of the Organisation internationale de la Francophonie (OIF), the community of 54 member states which share the official use or teaching of French. It is spoken as a first language (in descending order of the number of speakers) in France; Canada (especially in
14012-510: Was approved for medical use in the United States in 2019, for the treatment of cases that can benefit from skipping exon 53 of the dystrophin transcript. The Morpholino antisense oligonucleotide viltolarsen (Viltepso) was approved for medical use in the United States in August 2020, for the treatment of Duchenne muscular dystrophy (DMD) in people who have a confirmed mutation of the DMD gene that
14136-571: Was chief physician of the Hospice from 1795 to his death in 1826. The Salpêtrière was, at the time, like a large village, with seven thousand elderly indigent and ailing women, an entrenched bureaucracy, a teeming market and huge infirmaries. Pinel created an inoculation clinic in his service at the Salpêtrière in 1799 and the first vaccination in Paris was given there in April 1800. Through its history,
14260-542: Was completed in 1669. In 1684 a women's prison was added to the site with a total capacity of 300 convicted prostitutes . It provided wretched living conditions for its inmates. On the eve of the Revolution , Pitié-Salpêtrière Hospice had become the world's largest hospice , with a capacity of 10,000 "patients" and over 300 prisoners. Until the French Revolution , the Salpêtrière had no medical function:
14384-819: Was during the period of the Crusades in which French became so dominant in the Mediterranean Sea that became a lingua franca ("Frankish language"), and because of increased contact with the Arabs during the Crusades who referred to them as Franj , numerous Arabic loanwords entered French, such as amiral (admiral), alcool (alcohol), coton (cotton) and sirop (syrop), as well as scientific terms such as algébre (algebra), alchimie (alchemy) and zéro (zero). Within Old French many dialects emerged but
14508-611: Was first described by the Neapolitan physician Giovanni Semmola in 1834 and Gaetano Conte in 1836. However, Duchenne muscular dystrophy is named after the French neurologist Guillaume-Benjamin-Amand Duchenne (1806–1875), who in the 1861 edition of his book Paraplégie hypertrophique de l'enfance de cause cérébrale , described and detailed the case of a boy who had this condition. A year later, he presented photos of his patient in his Album de photographies pathologiques . In 1868, he gave an account of 13 other affected children. Duchenne
14632-400: Was gradually adopted by the inhabitants of Gaul. As the language was learned by the common people, it developed a distinct local character, with grammatical differences from Latin as spoken elsewhere, some of which is attested in graffiti. This local variety evolved into the Gallo-Romance tongues, which include French and its closest relatives, such as Arpitan . The evolution of Latin in Gaul
14756-652: Was known in the Occitan-speaking region as Vergonha . Spoken by 19.71% of the European Union's population, French is the third most widely spoken language in the EU, after English and German and the second-most-widely taught language after English. Under the Constitution of France , French has been the official language of the Republic since 1992, although the Ordinance of Villers-Cotterêts made it mandatory for legal documents in 1539. France mandates
14880-594: Was shaped by its coexistence for over half a millennium beside the native Celtic Gaulish language , which did not go extinct until the late sixth century, long after the fall of the Western Roman Empire . The population remained 90% indigenous in origin; the Romanizing class were the local native elite (not Roman settlers), whose children learned Latin in Roman schools. At the time of the collapse of
15004-607: Was the 29-year old Sigmund Freud who translated Charcot's lectures into German and whose deconstruction of the lectures on hysteria formed the foundations of psychoanalysis . The first English translations of Charcot's Clinical Lectures (1877, 1881) were published by the Irish physician and politician George Sigerson . Public health physician and advocate of breastfeeding Truby King traveled from New Zealand to witness Charcot, reporting his clinical demonstrations seminal. A rather negative portrait of Charcot's clinical style emerges in
15128-454: Was the chief physician of the Salpêtrière by 1794, in charge of a 200-bed infirmary which housed a tiny proportion of the huge indigent female population. He was succeeded by his assistant Jean-Étienne Dominique Esquirol (1772–1840) who, from 1817, delivered the first systematic lectures on psychiatry in France and was the chief architect of the lunacy legislation of 30 June 1838. Esquirol was followed by Étienne Pariset ; and from 1831 till 1867
15252-486: Was the first to do a biopsy to obtain tissue from a living patient for microscopic examination. Efforts are ongoing to find medications that either return the ability to make dystrophin or utrophin. Other efforts include trying to block the entry of calcium ions into muscle cells. Antisense oligonucleotides (oligos), structural analogs of DNA, are the basis of a potential treatment for 10% of people with Duchenne muscular dystrophy. The compounds allow faulty parts of
15376-570: Was the language they use the most at home rose from 67% at the 2007 census to 74% at the 2017 census. In Wallis and Futuna, the percentage of the population who reported that French was the language they use the most at home rose from 10% at the 2008 census to 13% at the 2018 census. According to a demographic projection led by the Université Laval and the Réseau Démographie de l'Agence universitaire de la Francophonie ,
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