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Sandoz Group AG is a Swiss company that focuses on generic pharmaceuticals and biosimilars. Prior to October 2023, it was part of a division of Novartis that was established in 2003, when Novartis united all of its generics businesses under the name Sandoz. Before this, the company existed as an independent pharmaceutical manufacturer until 1996, when it was merged with Ciba-Geigy to form Novartis. Prior to the merger, it specialized in medicines used in organ transplants, such as Sandimmune , and various antipsychotics and migraine medicines. Its headquarters were in Holzkirchen , Germany and after the spin-off from Novartis, the headquarters moved to Basel, Switzerland. Sandoz is one of the leading global generics businesses.

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69-480: The company was founded in 1886 by Alfred Kern (1850–1893) and Edouard Sandoz (1853–1928) in Basel (Switzerland) under the name Chemiefirma Kern und Sandoz . Initially the company focused on production of dyes namely alizarin blue and auramine . When Kern died, the company changed its name to Chemische Fabrik vormals Sandoz in 1895 and began producing pharmaceuticals for the first time the same year. As early as 1895,

138-435: A Time magazine feature. Research on LSD peaked in the 1950s and early 1960s. The CIA purchased quantities of LSD from Sandoz for use in its illegal human experimentation program known as MKUltra . Sandoz withdrew the drug from the market in 1965. The drug became a cultural novelty of the 1960s after psychologist Timothy Leary at Harvard University began to promote its use for recreational and spiritual experiences among

207-401: A bishops' crozier as the heraldic charge in the coat of arms of Basel first appears in the form of a gilded wooden staff in the 12th century. It is of unknown origin or significance (beyond its obvious status of bishop's crozier), but it is assumed to have represented a relic, possibly attributed to Saint Germanus of Granfelden . This staff (known as Baselstab ) became a symbol representing

276-427: A century earlier. For many centuries to come Basel possessed the only permanent bridge over the river "between Lake Constance and the sea". The first city guild were the furriers , established in 1226. A total of about fifteen guilds were established in the course of the 13th century, reflecting the increasing economic prosperity of the city. The Crusade of 1267 set out from Basel. Political conflicts between

345-462: A commercial hub and an important cultural centre since the Renaissance , and has emerged as a centre for the chemical and pharmaceutical industries in the 20th century. In 1897, Basel was chosen by Theodor Herzl as the location for the first World Zionist Congress , and altogether the congress was held there ten times over a time span of 50 years, more than in any other location. The city

414-515: A curfew of several hours was imposed. No people suffered acute harm, with the exception of three people with pre-existing asthma who required hospitalization. However, the toxins found their way into the Rhine via the extinguishing water, where they caused a large number of fish to die off. On November 11, 1986, the analysis of water samples proved that at the same time as the Rhine was being polluted by

483-536: A handful of wealthy families collectively referred to as the "Daig" played a pivotal role in city affairs as they gradually established themselves as a de facto city aristocracy . The first edition of Christianae religionis institutio ( Institutes of the Christian Religion – John Calvin 's great exposition of Calvinist doctrine) was published at Basel in March 1536. In 1544, Johann von Brugge,

552-514: A pro-Habsburg faction, known as Sterner , and an anti-Habsburg faction, the Psitticher . The Black Death reached Basel in 1348. The Jews were blamed , and an estimated 50 to 70 Jews were executed by burning on 16 January 1349 in what has become known as the Basel massacre . The Basel earthquake of 1356 destroyed much of the city along with a number of castles in the vicinity. A riot on 26 February 1376, known as Böse Fasnacht , led to

621-570: A rich Dutch Protestant refugee, was given citizenship and lived respectably until his death in 1556, then buried with honors. His body was exhumed and burnt at the stake in 1559 after it was discovered that he was the Anabaptist David Joris . In 1543, De humani corporis fabrica , the first book on human anatomy, was published and printed in Basel by Andreas Vesalius (1514–1564). There are indications Joachim Meyer , author of

690-806: A single global brand, reestablishing the name Sandoz as a division of Novartis. The Amifarma S.L. production plant in Palafolls, located near Barcelona, Spain was also acquired. In February 2005, Sandoz acquired over Hexal AG and Eon Labs. The integration into Sandoz created the second largest generics group in the world and the largest on the German market with annual sales of 7.6 billion US dollars (2008) and over 23,000 employees in 130 countries. The headquarters have been in Holzkirchen since 2005. Sandoz's Swiss administrative headquarters are in Rotkreuz ZG in

759-526: Is May during which time Basel receives an average of 98 mm (3.9 in) of rain. The month with the most days of precipitation is also May, with an average of 11.7 days. The driest month of the year is February with an average of 45 mm (1.8 in) of precipitation over 8.4 days. The city of Basel functions as the capital of the Swiss half-canton of Basel-Stadt . The canton Basel-Stadt consists of three municipalities: Riehen , Bettingen , and

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828-532: Is also home to the world headquarters of the Bank for International Settlements . The name of the city is internationally known through institutions like the Basel Accords , Art Basel and FC Basel . Basel is Switzerland's main centre for the pharmaceutical industry, hosting both Novartis and Roche . In 2019 Basel was ranked the tenth most liveable city in the world by Mercer . The name of Basel

897-593: Is first recorded as Basilia in the 3rd century (237/8), at the time referring to the Roman castle . This name is mostly interpreted as deriving from the personal name Basilius , from a toponym villa Basilia (" estate of Basilius") or similar. Another suggestion derives it from a name Basilia attested in northern France as a development of basilica , the term for a public or church building (as in Bazeilles ), but all of these names reference early church buildings of

966-446: Is forested. Of the rest of the land, 20.67 km (7.98 sq mi) or 86.4% is settled (buildings or roads), 1.45 km (0.56 sq mi) or 6.1% is either rivers or lakes. Of the built up area, industrial buildings made up 10.2% of the total area while housing and buildings made up 40.7% and transportation infrastructure made up 24.0%. Power and water infrastructure as well as other special developed areas made up 2.7% of

1035-738: Is located in Northwestern Switzerland and is commonly considered to be the capital of that region. It is close to the point where the Swiss, French and German borders meet, and Basel also has suburbs in France and Germany. As of 2016 , the Swiss Basel agglomeration was the third-largest in Switzerland, with a population of 541,000 in 74 municipalities in Switzerland (municipal count as of 2018). The metropolitan area , called

1104-411: Is recorded for 1185, and the first mayor , Heinrich Steinlin of Murbach, for 1253. The first bridge across the Rhine was built in 1225 under bishop Heinrich von Thun (at the location of the modern Middle Bridge ), and from this time the settlement of Kleinbasel gradually formed around the bridgehead on the far river bank. The bridge was largely funded by Basel's Jewish community who had settled there

1173-410: Is used for agricultural purposes, while 15.4% is forested. Of the rest of the land, 21.3% is settled (buildings or roads) and the remainder (2.4%) is non-productive (rivers, glaciers or mountains). The combined municipality of Risch-Rotkreuz has an area of 22.9 km (8.8 sq mi). Risch-Rotkreuz has a population (as of 31 December 2020) of 11,212. As of 2020 , about 27.1% of the population

1242-464: The BBC . Currently, the spelling Basel is most often used, to match the official German spelling. In French Basle was still in use in the 18th century, but was gradually replaced by the modern French spelling Bâle . In Icelandic, the city is recorded as Buslaraborg in the 12th-century itinerary Leiðarvísir og borgarskipan . There are traces of a settlement at the nearby Rhine knee from

1311-460: The Baselstab in red represented the bishop, and the same charge in black represented the city. The blazon of the municipal coat of arms is In Silber ein schwarzer Baselstab (Argent, a staff of Basel sable). In 1400, Basel was able to purchase the towns of Liestal , Homburg and Waldenburg with its surrounding territory. In 1412 (or earlier), the well-known Gasthof zum Goldenen Sternen

1380-697: The Fondation Beyeler (located in Riehen ), the Museum Tinguely and the Museum of Contemporary Art , which is the first public museum of contemporary art in Europe. Forty museums are spread throughout the city-canton, making Basel one of the largest cultural centres in relation to its size and population in Europe. The University of Basel , Switzerland's oldest university (founded in 1460), and

1449-737: The French Revolutionary Wars . In more recent times, the World Zionist Organization held its first congress in Basel from 29 August through 31 August 1897. Because of the Balkan Wars , the (Socialist) Second International held an extraordinary congress at Basel in 1912. In 1989, the Basel Convention was opened for signature with the aim of preventing the export of hazardous waste from wealthy to developing nations for disposal. Basel

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1518-473: The Roman invasion of Gaul . In Roman Gaul , Augusta Raurica was established some 20 km (12 mi) from Basel as the regional administrative centre, while a castrum (fortified camp) was built on the site of the Celtic oppidum . In AD 83, the area was incorporated into the Roman province of Germania Superior . The Roman Senator Munatius Plancus is known as the traditional founder of Basel since

1587-606: The Swabian League of Cities in 1385, and many knights of the pro-Habsburg faction, along with duke Leopold himself, were killed in the Battle of Sempach the following year. A formal treaty with Habsburg was made in 1393. Basel had gained its de facto independence from both the bishop and from the Habsburgs and was free to pursue its own policy of territorial expansion, beginning around 1400. The unique representation of

1656-625: The Swiss Reformed Church , 14.7% belong to another church and 13.2% do not belong to any organized church. The largest firm in Risch-Rotkreuz is Roche Diagnostics International AG. Risch-Rotkreuz has an unemployment rate of 2.3%. As of 2005 , there were 145 people employed in the primary economic sector and about 47 businesses involved in this sector. 2,162 people are employed in the secondary sector and there are 95 businesses in this sector. 4,220 people are employed in

1725-721: The Treaty of Meerssen of 870. Basel was destroyed by the Magyars in 917. The rebuilt town became part of Upper Burgundy , and as such was incorporated into the Holy Roman Empire in 1032. From the donation by Rudolph III of Burgundy of the Moutier-Grandval Abbey and all its possessions to Bishop Adalbero II of Metz in 999 until the Reformation , Basel was ruled by Prince-Bishops . In 1019,

1794-478: The Trinational Eurodistrict of Basel (TEB), consists of 62 suburban communes including municipalities in neighboring countries, and counted 829,000 inhabitants in 2007. Basel has an area, as of 2009 , of 23.91 square kilometers (9.23 sq mi). Of this area, 0.95 km (0.37 sq mi) or 4.0% is used for agricultural purposes, while 0.88 km (0.34 sq mi) or 3.7%

1863-536: The Zoo Basel , opened its doors in the south of the city towards Binningen . In 1897 the first World Zionist Congress was held in Basel. Altogether the World Zionist Congress was held in Basel ten times, more than in any other city in the world. On 16 November 1938, the psychedelic drug LSD was first synthesized by Swiss chemist Albert Hofmann at Sandoz Laboratories in Basel. In 1967,

1932-718: The tertiary sector , with 576 businesses in this sector. Risch-Rotkreuz is near the two motorways A4 and A14. By train, you can reach the municipality with the SBB . There is a very important station in Rotkreuz because the railway line crossing the Alps via the Gotthard Pass crosses the Intercity line from Zürich to Lucerne here. On the lake you can go by ship to Cham, Zug and Arth. SIS Swiss International School Rotkreuz-Zug

2001-546: The 4th century, but were repelled; one such event was the Battle of Solicinium (368). However, in the great invasion of AD 406, the Alemanni appear to have crossed the Rhine a final time, conquering and then settling what is today Alsace and a large part of the Swiss Plateau . The Duchy of Alemannia fell under Frankish rule in the 6th century. The Alemannic and Frankish settlement of Basel gradually grew around

2070-502: The 4th or 5th century and cannot be adduced for the 3rd-century attestation of Basilia . By popular etymology, or simple assonance, the basilisk becomes closely associated with the city, used as heraldic supporter from 1448, represented on coins minted by the city, and frequently found in ornaments. The Middle French form Basle was adopted into English, but this form has fallen gradually out of use although it continues to be used in some sections of British English including

2139-431: The Basel diocese, depicted in bishops' seals of the late medieval period. It is represented in a heraldic context in the early 14th century, not yet as a heraldic charge but as a kind of heraldic achievement flanked by the heraldic shields of the bishop. The staff is also represented in the bishops's seals of the period. The use of the Baselstab in black as the coat of arms of the city was introduced in 1385. From this time,

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2208-664: The Ecclesiastical Princes of the Imperial Diet . In 1500 the construction of the Basel Münster was finished. The city had remained neutral through the Swabian War of 1499 despite being plundered by soldiers on both sides. The Treaty of Basel ended the war and granted the Swiss confederates exemptions from the emperor Maximillian's taxes and jurisdictions, separating Switzerland de facto from

2277-648: The Holy Roman Empire. On 9 June 1501, Basel joined the Swiss Confederation as its eleventh canton . It was the only canton that was asked to join, not the other way round. Basel had a strategic location, good relations with Strasbourg and Mulhouse , and control of the corn imports from Alsace, whereas the Swiss lands were becoming overpopulated and had few resources. A provision of the Charter accepting Basel required that in conflicts among

2346-741: The Renaissance. Roman control over the area deteriorated in the 3rd century, and Basel became an outpost of the Provincia Maxima Sequanorum formed by Diocletian . Basilia is first named by the Ammianus Marcellinus in his Res Gestae as part of the Roman military fortifications along the Rhine in the late 4th century. The Germanic confederation of the Alemanni attempted to cross the Rhine several times in

2415-536: The Swedish crisp bread producer Wasa in 1982. In 1986, Velsicol Chemical Corporation acquired the agrochemicals division of Sandoz. In 1994, Sandoz bought Gerber Products Company, expanding its research into biopharmacueticals. In 1995, the specialty chemicals division became an independent company under the name Clariant , based in Muttenz . On December 20, 1996, the merger of Sandoz and Ciba-Geigy led to

2484-494: The ancient bishopric of Augusta Raurica , was established in the 8th century. Under bishop Haito (r. 806–823), the first cathedral was built on the site of the Roman castle (replaced by a Romanesque structure consecrated in 1019). At the partition of the Carolingian Empire through the Treaty of Verdun in 843, Basel was first given to West Francia and became its German exclave. It passed to East Francia with

2553-723: The area while parks, green belts and sports fields made up 8.9%. Out of the forested land, all of the forested land area is covered with heavy forests. Of the agricultural land, 2.5% is used for growing crops and 1.3% is pastures. All the water in the municipality is flowing water. Under the Köppen system , Basel features an oceanic climate (Köppen: Cfb ), although with notable continental influences due to its relatively far inland position with cool to cold, overcast winters and warm to hot, humid summers. The city averages 118.2 days of rain or snow annually and on average receives 842 mm (33.1 in) of precipitation . The wettest month

2622-399: The bishops and the burghers began in the mid-13th century and continued throughout the 14th century. By the late 14th century, the city was for all practical purposes independent although it continued to nominally pledge fealty to the bishops. The House of Habsburg attempted to gain control over the city. This was not successful, but it caused a political split among the burghers of Basel into

2691-529: The cause. Subsequent trials, however, resulted in no conviction. The plant now belongs to Clariant . To this day, the landfill left after the fire continues to pollute the groundwater in Muttenz and is actively monitored by Novartis, as the legal successor to Sandoz, and the environmental authorities of the Canton of Basel-Landschaft. To commemorate the spill, there is a plastic market table by Bettina Eichin in

2760-489: The city Basel itself. The political structure and agencies of the city and the canton are identical. Risch-Rotkreuz Risch is a municipality in the canton of Zug in Switzerland . It is also promoted as Risch-Rotkreuz . Four villages (Rotkreuz, Risch, Buonas and Holzhäusern) belong to the municipality Risch . On 24 November 2007 it was decided to promote the municipality as Risch-Rotkreuz . The change

2829-495: The city municipality limits. The official language of Basel is Swiss Standard German and the main spoken language is the local Basel German dialect. Basel is commonly considered to be the cultural capital of Switzerland and the city is famous for its many museums , including the Kunstmuseum , which is the first collection of art accessible to the public in the world (1661) and the largest museum of art in Switzerland ,

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2898-571: The city's centuries-long commitment to humanism , have made Basel a safe haven at times of political unrest in other parts of Europe for such notable people as Erasmus of Rotterdam , the Holbein family, Friedrich Nietzsche , Carl Jung , and in the 20th century also Hermann Hesse and Karl Jaspers . Basel was the seat of a Prince-Bishopric starting in the 11th century, and joined the Swiss Confederacy in 1501. The city has been

2967-579: The cloister of Basel Munster . Basel Basel ( / ˈ b ɑː z əl / BAH -zəl ; German: [ˈbaːzl̩] ), also known as Basle , is a city in northwestern Switzerland on the River Rhine (at the transition from the High to the Upper Rhine ). Basel is Switzerland's third-most-populous city (after Zurich and Geneva ), with 177,595 inhabitants within

3036-483: The construction of the cathedral of Basel (known locally as the Münster ) began under Henry II, Holy Roman Emperor . In the 11th to 12th century, Basel gradually acquired the characteristics of a medieval city . The main market place is first mentioned in 1091. The first city walls were constructed around 1100 (with improvements made in the mid-13th and in the late 14th century). A city council of nobles and burghers

3105-473: The contaminated extinguishing water from the Sandoz area, 400 kg of atrazine , a herbicide, had been discharged into the Rhine from the neighboring chemical company Ciba-Geigy. The official investigation report came to the conclusion (only " on the basis of theoretical considerations ") that when pallets were packed with Prussian blue, incorrect handling of a hot air blower led to a hot spot, which could be

3174-619: The creation of Novartis. The Sandoz brand name was then only used in the pharmaceutical business for over-the-counter medicines. The former company name Sandoz was reactivated in May 2003 with the merger of the globally differently named generics companies of the parent company Novartis under the uniform brand name Sandoz. In addition to the name, the company logo used before the merger was also adopted. In 2002, Sandoz acquired Lek Pharmaceuticals d.d., Slovenia's largest pharmaceutical company. In 2003, Novartis united its global generics businesses under

3243-605: The early La Tène period (5th century BC). In the 2nd century BC, there was a village of the Raurici at the site of Basel-Gasfabrik (to the northwest of the Old City, and likely identical with the town of Arialbinnum that was mentioned on the Tabula Peutingeriana ). The unfortified settlement was abandoned in the 1st century BC in favour of an oppidum on the site of Basel Minster , probably in reaction to

3312-403: The first pharmaceutical substance called antipyrine was produced to reduce fever. In 1899 they started producing saccharin . In 1917, Sandoz entered pharmaceutical research when Arthur Stoll (1887–1971) was hired, and, in 1929, Calcium Sandoz was introduced, laying the foundation research into modern calcium therapy. In 1918, Arthur Stoll isolated ergotamine from ergot ; the substance

3381-417: The general public. In 1939, Kern & Sandoz became Sandoz Ltd., a name it operated under for nearly sixty years. In 1963, Sandoz acquired Biochemie GmbH, which was producing and supplying scarce, urgently needed acid-resistant penicillin. In 1967, Sandoz merged with Wander AG and diversified into the dietetics business with Ovomaltine and Isostar . In 1972, Sandoz acquired Delmark, Wasabröd, Wasa,

3450-436: The generic (topical) dermatology business. In November 2018, it was announced that Novartis would convert Sandoz into an independent entity over the next two years. In March 2019, it was announced that CEO Richard Francis had resigned for personal reasons and that Francesco Balestrieri, Sandoz's European head, had taken over management ad interim. Richard Saynor was appointed as CEO later in 2019. In August 2022, Novartis said

3519-653: The influential 16th-century martial arts text Kunst des Fechten ("The Art of Fencing"), came from Basel. In 1661 the Amerbaschsches Kabinett , a vast collection of exotic artifacts, coins, medals and books was purchased by Basel. It was to become to the first public museum of art. Its collection became the core of the later Basel Museum of Art . The Bernoulli family, which included important 17th- and 18th-century mathematicians such as Jakob Bernoulli , Johann Bernoulli and Daniel Bernoulli , were from Basel. The 18th-century mathematician Leonhard Euler

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3588-423: The killing of a number of men of Leopold III, Duke of Austria . This was seen as a serious breach of the peace , and the city council blamed "foreign ruffians" for this and executed twelve alleged perpetrators. Leopold nevertheless had the city placed under imperial ban , and in a treaty of 9 July, Basel was given a heavy fine and was placed under Habsburg control. To free itself from Habsburg hegemony, Basel joined

3657-595: The land around Farnsburg became a part of Basel. The Schwabe publishing house was founded in 1488 by Johannes Petri and is the oldest publishing house still in business. Johann Froben also operated his printing house in Basel and was notable for publishing works by Erasmus. In 1495, Basel was incorporated into the Upper Rhenish Imperial Circle ; the Bishop of Basel was added to the Bench of

3726-672: The municipality of Risch in the canton of Zug. In 2006, Omnitrope , a recombinant human growth hormone, was approved by the European Medicines Agency (EMA) and also became the first biosimilar to receive approval from the FDA. In 2007, the first complex biosimilar, Binocrit was approved in the EU. In 2009, Sandoz acquired EBEWE Pharma's specialty generic injectables division and in 2010, acquired Oriel Therapeutics. In 2012, Sandoz acquired Fougera Pharmaceuticals, entering

3795-432: The name Delysid . It was marketed as a treatment for a wide variety of mental ailments , ranging from alcoholism to sexual deviancy . Sandoz suggested in its marketing literature that psychiatrists take LSD themselves, to gain a better subjective understanding of the schizophrenic experience, and many did exactly that and so did other scientific researchers. The Sandoz product received mass publicity as early as 1954, in

3864-479: The new headquarters in Basel, Switzerland. On November 1, 1986, a major fire broke out in a warehouse containing 1,350 tonnes (2,980,000 lb) of chemicals in what was then Sandoz in Schweizerhalle . The thick smoke, the stench and the unknown composition of the combustion gases caused the authorities in the neighboring communities to alert the population early in the morning with a general siren alarm and

3933-583: The next month, resulting in Novartis shareholders receiving one Sandoz share for every five Novartis shares. Sandoz was listed on the SIX Swiss Exchange with a market capitalization between $ 18 billion and $ 25bn. On October 4, 2023, Novartis completed the spin-off of Sandoz as a stand-alone company. In January 2024, Sandoz announced it would acquire biosimilar drug for vision Cimerli For $ 170 million from Coherus BioSciences. The acquisition

4002-524: The old Roman castle in the 6th and 7th century. It appears that Basel surpassed the ancient regional capital of Augusta Raurica by the 7th century; based on the evidence of a gold tremissis (a small gold coin with the value of a third of a solidus ) with the inscription Basilia fit , Basel seems to have minted its own coins in the 7th century. Basel at this time was part of the Archdiocese of Besançon . A separate bishopric of Basel , replacing

4071-445: The other cantons it was to stay neutral and offer its services for mediation. In 1503, the new bishop Christoph von Utenheim refused to give Basel a new constitution; whereupon, to show its power, the city began to build a new city hall. In 1529, the city became Protestant under Oecolampadius and the bishop's seat was moved to Porrentruy . The bishop's crook was however retained as the city's coat of arms. For centuries to come,

4140-416: The population of Basel voted in favor of buying three works of art by painter Pablo Picasso which were at risk of being sold and taken out of the local museum of art, due to a financial crisis on the part of the owner's family. Therefore, Basel became the first city in the world where the population of a political community democratically decided to acquire works of art for a public institution. Pablo Picasso

4209-514: The spin-off of Sandoz into a standalone company would be completed by the end of 2023. As part of the spin-off, Sandoz announced in June 2023 it would move its headquarters from Holzkirchen , Germany to Basel, Switzerland. In July 2023, Sandoz launched a biosimilar version of AbbVie Inc 's Humira , under the label, Hyrimoz . In September 2023, Novartis announced that the spin-off had been approved by its shareholders and that it would be completed by

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4278-583: The vote. The next three most popular parties were the FDP (28.6%), the CVP (18.2%) and the Green Party (12.2%). In Risch about 71.5% of the population (between age 25-64) have completed either non-mandatory upper secondary education or additional higher education (either university or a Fachhochschule ). The majority of the population is Roman Catholic (58%). Of the rest of the population, 14.1% belong to

4347-451: Was born in Basel and studied under Johann Bernoulli. In 1792, the Republic of Rauracia , a revolutionary French client republic , was created. It lasted until 1793. After three years of political agitation and a short civil war in 1833 the disadvantaged countryside seceded from the Canton of Basel, forming the half canton of Basel-Landschaft . Between 1861 and 1878 the city walls were slighted . On 3 July 1874, Switzerland's first zoo,

4416-516: Was completed in March 2024. In February 2024, Sandoz US and its subsidiary Fougera Pharmaceuticals Inc. - indirect subsidiaries of Sandoz Group AG reached a USD 265 million settlement agreement in the US related to a generics direct purchaser class action lawsuit. In April 2024, Sandoz reached an agreement with Amgen to resolve all patent disputes between the two companies relating to the US Food and Drug Administration (FDA)-approved Sandoz denosumab biosimilars. In November 2024, Sandoz inaugurated

4485-429: Was established. Basel became the focal point of western Christendom during the 15th century Council of Basel (1431–1449), including the 1439 election of antipope Felix V . In 1459, Pope Pius II endowed the University of Basel , where such notables as Erasmus of Rotterdam and Paracelsus later taught. At the same time the new craft of printing was introduced to Basel by apprentices of Johann Gutenberg . In 1461,

4554-420: Was eventually used to treat migraine and headaches and was introduced under the trade name Gynergen in 1921. In 1938 Albert Hofmann produced the synthetic substance lysergic acid diethylamide , better known as LSD. The psychoactive properties of this preparation were nevertheless not discovered until 1943, when Hofmann ingested a small amount by accident. From 1947 to the mid-60s, LSD was sold by Sandoz under

4623-470: Was made because the village Rotkreuz has become much bigger than Risch . The municipality is between the Lake of Zug and the river Reuss . In the south, the Rooterberg is a part of the municipality. Many little rivers and two little lakes flow in Risch-Rotkreuz. The municipality historically consists of the four villages of Risch, Buonas and Holzhäusern and Rotkreuz. Risch had an area, as of 2006 , of 14.8 km (5.7 sq mi). Of this area, 61%

4692-418: Was made up of foreign nationals. Over the last 10 years the population has grown at a rate of 29.3%. Most of the population (as of 2000 ) speaks German (84.3%), with Serbo-Croatian being second most common (3.3%) and Italian being third (2.7%). The population of Risch is 337, while Rotkreuz has a population of 7,425. In the 2007 federal election the most popular party was the SVP which received 34.1% of

4761-432: Was so moved by the gesture that he subsequently gifted the city with an additional three paintings. Basel has often been the site of peace negotiations and other international meetings. The Treaty of Basel (1499) ended the Swabian War . Two years later Basel joined the Swiss Confederation . The Peace of Basel in 1795 between the French Republic and Prussia and Spain ended the First Coalition against France during

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