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25-533: Skylines may refer to Skylines (film) , a 2020 science fiction action film Skylines (TV series) , a 2019 German drama series Skylines (album) , a 2005 album by Scott Liss Cities: Skylines , a 2015 city-building video game Cities: Skylines II , the sequel to the above video game set to be released in 2023 See also [ edit ] Skyline (disambiguation) Skyliner (disambiguation) Skyliners (disambiguation) Topics referred to by

50-537: A course set for the prison, intending to rescue her adoptive father. The film opened theatrically in Vietnam on December 11, and grossed $ 49,978 from 960 theaters in its opening weekend, ranking fifth with an average of $ 52 per theater. The film was pulled from 915 theaters in its second weekend, ranking eighth with $ 972 and a decrease of 98.1%. Rotten Tomatoes gives the film a 56% approval rating based on 27 reviews, with an average rating of 5.4/10. On Metacritic ,

75-631: A list of bio-agents designated by the U.S. Department of Health and Human Services or the U.S. Department of Agriculture that have the "potential to pose a severe threat to public health and safety" to be officially defined as " select agents " and possession or transportation of them are tightly controlled as such. Select agents are divided into "HHS select agents and toxins", "USDA select agents and toxins" and "Overlap select agents and toxins". The US Centers for Disease Control and Prevention (CDC) breaks biological agents into three categories: Category A, Category B, and Category C . Category A agents pose

100-438: A potential danger in a wide variety of occupational settings. The 1972 Biological Weapons Convention is an international treaty banning the development, use or stockpiling of biological weapons; as of March 2021, there were 183 states parties to the treaty. Bio-agents are, however, widely studied for both defensive and medical research purposes under various biosafety levels and within biocontainment facilities throughout

125-593: A pulse grenade to kill them. The team manages to reach the Armada where Rose is briefly possessed by the Harvester Matriarch, who accuses the humans of coming to destroy her species. Trent helps Rose to break free of the Matriarch's control and Rose realizes that the alien's telepathic influence was what caused her to freeze in the war. Now no longer afraid of who she is, Rose embraces her powers and steals

150-607: Is different from Wikidata All article disambiguation pages All disambiguation pages Skylines (film) The film premiered at the London FrightFest film festival on October 25, 2020, and was released on December 18, 2020, in the United States in theaters and on Apple TV by Vertical Entertainment (all during the COVID-19 pandemic ). Picking up shortly after the previous film, Rose leads

175-485: Is disintegrated. Trent, whom Leon manages to snap back to normal, knocks the Matriarch in as well, but has most of his body disintegrated in the process. On Earth, Mal works on a cure, but the infected Pilots attack before she can finish testing it. The residents, including Mal, Kate, Grant and Huana, fight back and manage to eliminate the attacking Pilots at the cost of Grant and several others, only to have an army of thousands more approach from London. Arriving back just in

200-438: The Armada . Wracked with guilt, Rose vanishes while humanity rebuilds, living alongside billions of 'Pilots', freed alien-human hybrids. Five years after the battle, Rose lives in a tent city near the ruins of London, avoiding resistance forces searching for her and keeping the aging effects of her hybrid nature at bay with the help of hyper-oxygenated blood transfusions prepared by her friend Dr. Mal. A viral pandemic strikes

225-501: The Geneva Protocol, several countries made reservations regarding its applicability and use in retaliation. Due to these reservations, it was in practice a " no-first-use " agreement only. The 1972 Biological Weapons Convention supplements the Geneva Protocol by prohibiting the development, production, acquisition, transfer, stockpiling and use of biological weapons. Having entered into force on 26 March 1975, this agreement

250-515: The Pilots and anyone using transplanted Pilot limbs. The virus eats the Pilots alive while reverting them back into their brainwashed state. Resistance leader Leon captures Rose and brings her before General Radford who reveals that the Armada's core drive warped to Cobalt One, the Harvester homeworld, before the ship's destruction. Only with the Armada's core drive do they have a chance of saving

275-490: The Pilots. Rose reluctantly agrees to join the mission. At Cobalt One, the team's ship crashes after a collision that leaves it running on emergency power. The crew of Rose, her Pilot adoptive brother Trent, Leon, Owens and Alexi find the planet filled with the bodies of dead Harvesters. There are also strange shadow creatures that appear to be mutations of the Harvesters. Alexi is heavily wounded and sacrifices herself with

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300-703: The ability to adversely affect human health in a variety of ways, ranging from relatively mild allergic reactions to serious medical conditions, including serious injury, as well as serious or permanent disability or even death . Many of these organisms are ubiquitous in the natural environment where they are found in water, soil, plants, or animals. Bio-agents may be amenable to "weaponization" to render them easier to deploy or disseminate. Genetic modification may enhance their incapacitating or lethal properties, or render them impervious to conventional treatments or preventives. Since many bio-agents reproduce rapidly and require minimal resources for propagation, they are also

325-580: The absence of any formal verification regime to monitor compliance. In 1985, the Australia Group was established, a multilateral export control regime of 43 countries aiming to prevent the proliferation of chemical and biological weapons. In 2004, the United Nations Security Council passed Resolution 1540 , which obligates all UN Member States to develop and enforce appropriate legal and regulatory measures against

350-443: The core drive. However, Owens betrays the others, infects Trent with the virus and flees with the core drive. Rose and Leon later discover that Radford bombed Cobalt One prior to their arrival with a biological weapon , the same virus that is infecting the Pilots on Earth. As the two make their way back aboard the ship, Radford uses the core drive to destroy Cobalt One and the Harvesters in an act of genocide . He reveals to them that

375-456: The efficiency of various dissemination techniques or the risks caused by the use of biological agents in bioterrorism . To simulate dispersal, attachment or the penetration depth in human or animal lungs, simulants must have particle sizes, specific weight and surface properties, similar to the simulated biological agent. The typical size of simulants (1–5 μm) enables it to enter buildings with closed windows and doors and penetrate deep into

400-400: The film has a weighted average score of 46 out of 100, based on 4 critics, indicating "mixed or average reviews". In December 2020, writer/director O'Donnell announced plans to continue the series, with intentions to bring back the principal cast. That same month, Frank Grillo expressed interest in reprising his role in the series. In January 2024, it was announced XYZ Films had acquired

425-571: The greatest threat to the US. Criteria for being a Category "A" agent include high rates of morbidity and mortality, ease of dissemination and communicability, ability to cause a public panic, and special action required by public health officials to respond. Category A agents include anthrax , botulism , plague , smallpox , and viral hemorrhagic fevers. Simulants are organisms or substances which mimic physical or biological properties of real biological agents, without being pathogenic. They are used to study

450-516: The human fleet against the aliens, ten years after the first invasion. Now called 'Harvesters', the aliens are on board the Armada , a mother ship in orbit of the Moon. After breaking through the enemy lines, Rose freezes before she can fire and one of her ships is destroyed. With the aliens preparing to fire on Earth, Rose is forced to destroy one of her own ships when it gets into the crossfire. She sacrifices thousands of humans, but succeeds in destroying

475-482: The international rights to the fourth Skyline film, titled Skyline: Warpath . Biological weapon Biological agents , also known as biological weapons or bioweapons , are pathogens used as weapons. In addition to these living or replicating pathogens , toxins and biotoxins are also included among the bio-agents. More than 1,200 different kinds of potentially weaponizable bio-agents have been described and studied to date. Some biological agents have

500-467: The lungs. This bears a significant health risk, even if the biological agent is normally not pathogenic. While the history of biological weapons use goes back more than six centuries to the siege of Caffa in 1346, international restrictions on biological weapons began only with the 1925 Geneva Protocol , which prohibits the use but not the possession or development of chemical and biological weapons in international armed conflicts. Upon ratification of

525-477: The nick of time, Rose sucks all of the Pilots into her ship. With Mal's cure and her ship, they now have the power to cure all of the infected Pilots worldwide. In the aftermath, Mal transplants Trent's brain into a new Pilot body, saving him. Zhi hacks into Radford's personal files and discovers the location of a prison where Radford had held anyone that he considered to be an enemy of the state , including Rose and Trent's long-missing father Mark Corley. Rose orders

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550-413: The same term [REDACTED] This disambiguation page lists articles associated with the title Skylines . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Skylines&oldid=1143287003 " Category : Disambiguation pages Hidden categories: Short description

575-499: The virus was intended to peacefully euthanize the Pilots and destroy the Harvesters, but it had the unintended side effect of reverting the Pilots back into their brainwashed state. Having boarded the ship as well, the Matriarch kills Radford, intending to destroy the Earth in revenge. After realizing the truth about the virus, Owens attacks Zhi, who manages to fight him off. As the ship enters a wormhole, Owens falls into an energy field and

600-407: The world. The former US biological warfare program (1943–1969) categorized its weaponized anti-personnel bio-agents as either "lethal agents" ( Bacillus anthracis , Francisella tularensis , Botulinum toxin ) or "incapacitating agents" ( Brucella suis , Coxiella burnetii , Venezuelan equine encephalitis virus , staphylococcal enterotoxin B ). Since 1997, United States law has declared

625-512: Was the first multilateral disarmament treaty to ban the production of an entire category of weapons of mass destruction. As of March 2021, 183 states have become party to the treaty . The treaty is considered to have established a strong global norm against biological weapons, which is reflected in the treaty's preamble, stating that the use of biological weapons would be "repugnant to the conscience of mankind". However, its effectiveness has been limited due to insufficient institutional support and

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