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Laboratorios Syntex SA (later Syntex Laboratories, Inc. ) was a pharmaceutical company formed in Mexico City in January 1944 by Russell Marker , Emeric Somlo, and Federico Lehmann to manufacture therapeutic steroids from the Mexican yams called cabeza de negro ( Dioscorea mexicana ) and Barbasco ( Dioscorea composita ). The demand for barbasco by Syntex initiated the Mexican barbasco trade .

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53-569: As the American Chemistry Society later explained: “In early 1944, the new Mexican company was chartered and named Syntex, S.A. (‘Synthesis and Mexico’). Russell Marker, shortly thereafter, left Syntex on account of his ruthless cofounder. Luis E. Miramontes , George Rosenkranz and Carl Djerassi 's successful synthesis of norethisterone (also known as norethindrone ) — which was later proven to be an effective pregnancy inhibitor — led to an infusion of capital into Syntex and

106-681: A congressional charter under Title 36 of the United States Code . Its headquarters are located in Washington, D.C., and it has a large concentration of staff in Columbus, Ohio . The ACS is a leading source of scientific information through its peer-reviewed scientific journals, national conferences, and the Chemical Abstracts Service . Its publications division produces over 80 scholarly journals including

159-722: A transnational corporation . Its foreign scientists had become frustrated with bureaucratic delays on the part of the Mexican government in granting work visas and approving necessary imports of pharmaceutical materials for their work. After 1959, Syntex was incorporated in Panama; its administration, research and marketing were conducted from Palo Alto; its manufacturing of bulk steroid intermediates remained in Mexico; and it also manufactured finished drugs at plants in Puerto Rico and

212-637: A debate between some research funders (including the federal government), which argued that research they funded should be presented freely to the public, and some publishers (including the ACS), which argued that the costs of peer-review and publishing justified their subscription prices. In 2006, Congress debated legislation that would have instructed the National Institutes of Health (NIH) to require all investigators it funded to submit copies of final, peer-reviewed journal articles to PubMed Central ,

265-611: A free-access digital repository it operates, within 12 months of publication. At the time the American Association of Publishers (of which ACS is a member) hired a public relations firm to counter the open access movement . In spite of publishers' opposition, the PubMed Central legislation was passed in December 2007 and became effective in 2008. As the open access issue has continued to evolve, so too has

318-625: A group of American chemists gathered at the Joseph Priestley House to mark the 100th anniversary of Priestley's discovery of oxygen . Although there was an American scientific society at that time (the American Association for the Advancement of Science , founded in 1848), the growth of chemistry in the U.S. prompted those assembled to consider founding a new society that would focus more directly on theoretical and applied chemistry. Two years later, on April 6, 1876, during

371-764: A meeting of chemists at the University of the City of New York (now New York University ) the American Chemical Society was founded. The society received its charter of incorporation from the State of New York in 1877. Charles F. Chandler , a professor of chemistry at Columbia University who was instrumental in organizing the society said that such a body would "prove a powerful and healthy stimulus to original research, ... would awaken and develop much talent now wasting in isolation, ... [bring] members of

424-449: A new constitution aimed at nationalizing the organization in 1890. In 1905, the American Chemical Society moved from New York City to Washington, D.C. ACS was reincorporated under a congressional charter in 1937. It was granted by the U.S. Congress and signed by president Franklin D. Roosevelt . ACS's headquarters moved to its current location in downtown Washington in 1941. ACS first established technical divisions in 1908 to foster

477-553: A restriction on the number of records that can be exported. None of the competing products, such as Web of Science (owned by Clarivate ), Scopus (owned by Elsevier ) and The Lens (owned by Cambia ) has similar restrictions. The ACS has been involved in numerous lawsuits regarding access to its databases, trademark rights, and copyrighted material. In many of these cases, the ACS lost or ended up with an unenforceable judgement. These include: Dialog v. American Chemical Society ,

530-438: A suit claiming antitrust violations in access to ACS databases, settled out of court in 1993; American Chemical Society v. Google , a suit claiming trademark violation, settled out of court in 2006; American Chemical Society v. Leadscope , a suit alleging stolen trade secrets, concluded in 2012 with ACS losing its trade secrets claim and Leadscope losing its counterclaim of defamation; against ResearchGate , where

583-425: A young Mexican chemist doing his undergraduate bachelor's thesis work at Syntex completed the synthesis of the 19-nor-17α-ethynyltestosterone or, for short 'norethisterone'—which turned out to be the first oral contraceptive to be synthesized.". Nobel Laureate Max Perutz added "the chemistry student Luis Miramontes, working under the direction of Djerassi and the director of the laboratory Jorge Rosenkranz synthesized

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636-496: Is a scientific society based in the United States that supports scientific inquiry in the field of chemistry . Founded in 1876 at New York University , the ACS currently has more than 155,000 members at all degree levels and in all fields of chemistry, chemical engineering , and related fields. It is one of the world's largest scientific societies by membership. The ACS is a 501(c)(3) non-profit organization and holds

689-578: Is an open access chemical database developed by the NIH's National Center for Biotechnology Information . The ACS raised concerns that the publicly supported PubChem database would duplicate and unfairly compete with their existing fee-based Chemical Abstracts Service and argued that the database should only present data created by the Molecular Libraries Screening Center initiative of the NIH. The ACS lobbied members of

742-512: Is the largest division of the Society. It marked its 100th anniversary in 2008. The first Chair of the Division was Edward Curtis Franklin . The Organic Division played a part in establishing Organic Syntheses , Inc. and Organic Reactions , Inc. and it maintains close ties to both organizations. The Division's best known activities include organizing symposia (talks and poster sessions) at

795-631: The American Institute of Chemical Engineers and the New York Academy of Sciences . He died in Mexico City in 2004. The scientific contributions of Luis Miramontes are extensive, including numerous publications and nearly 40 national and international patents in different areas such as organic chemistry , pharmaceutical chemistry , petrochemistry and atmospheric chemistry and polluting agents. On October 15, 1951, under

848-615: The United States Congress to rein in PubChem and hired outside lobbying firms to try to persuade congressional members, the NIH, and the Office of Management and Budget (OMB) against establishing a publicly funded database. The ACS was unsuccessful, and as of 2012 PubChem is the world's largest free chemical database. The ACS is also the only provider of a major scientific publication database ( SciFinder ) that imposes

901-495: The chemical sciences , co-owned, and collaboratively managed by the American Chemical Society (ACS), German Chemical Society (GDCh) , Royal Society of Chemistry (RSC) , the chemistry community, other societies, funders, and non-profits; open for submissions and available for all readers at ChemRxiv. In debates about free access to scientific information, the ACS has been described as "in an interesting dilemma, with some of its representatives pushing for open access and others hating

954-491: The phase rule . The Georgia Local Section of ACS has awarded the Herty Medal since 1933 recognizing outstanding chemists who have significantly contributed to their chosen fields. All chemists in academic, government, or industrial laboratories who have been residing in the southeastern United States for at least 10 years are eligible. The New York Section of ACS also gives Leadership Awards. The Leadership Awards are

1007-432: The $ 25 yearly dues. Any university may start its own ACS Student Chapter and receive benefits of undergraduate participation in regional conferences and discounts on ACS publications. The American Chemical Society administers 64 national awards, medals and prizes based on scientific contributions at various career levels that promote achievement across the chemical sciences. The ACS national awards program began in 1922 with

1060-424: The ACS launched a series of 9 open access journals under the name ACS Au (chemical symbol for gold) which include ACS Bio & Med Chem Au , ACS Engineering Au , ACS Environmental Au , ACS Materials Au , ACS Measurement Science Au , ACS Nanoscience Au , ACS Organic & Inorganic Au , ACS Physical Chem Au and ACS Polymers Au . In 2005, the ACS was criticized for opposing the creation of PubChem , which

1113-606: The ACS's position. In response to a 2013 White House Office of Science and Technology Policy directive that instructed federal agencies to provide greater access to federally funded research, the ACS joined other scholarly publishers in establishing the Clearinghouse for the Open Research of the United States (Chorus) to allow free access to published articles. The ACS has also introduced several open access publishing options for its journals, including providing authors

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1166-502: The American Chemical Society in all 50 states, the District of Columbia, and Puerto Rico. International Chemical Sciences Chapters allow ACS members outside of the U.S. to organize locally for professional and scientific exchange. There are currently 24 International Chemical Sciences Chapters. ACS states that it offers teacher training to support the professional development of science teachers so they can better present chemistry in

1219-403: The American Chemical Society. They elect their own officers and select representatives to the national ACS organization. Local sections also provide professional development opportunities for members, organize community outreach events, offer awards, and conduct other business. The Rhode Island Section was the first local section of ACS, organized in 1891. There are currently 186 local sections of

1272-845: The Bahamas. Syntex agreed to be acquired by the Roche group in May 1994. After the acquisition closed, Roche downsized Syntex's research and development facilities in the Stanford Research Park and finally shut down what was left of Syntex in September 2008. In 2011, VMware moved into the former Syntex campus in Palo Alto. Syntex submitted its compound to a laboratory in Madison, Wisconsin , for biological evaluation, and found it

1325-651: The E. Ann Nalley Regional Award for Volunteer Service to the American Chemical Society, Regional Awards for Excellence in High School Teaching, and the Stanley C. Israel Regional Award for Advancing Diversity in the Chemical Sciences. ACS Publications is the publishing division of the ACS. It is a nonprofit academic publisher of scientific journals covering various fields of chemistry and related sciences. As of 2021, ACS Publications published

1378-515: The Mexican steroid pharmaceutical industry. George Rosenkranz and Carl Djerassi went on to synthesize cortisone from diosgenin , the same phytosteroid contained in Mexican yams used to synthesize progesterone and norethindrone. The synthesis was more economical than the previous Merck & Co. synthesis, which started with bile acids . In 1959, Syntex moved its operating headquarters to Palo Alto, California , United States, and evolved into

1431-779: The Syntex patent. Searle obtained approval to market noretynodrel before Syntex received its approval. By 1964 three companies, including Syntex, G.D. Searle , and Johnson & Johnson under the Ortho Pharmaceutical brand, were marketing 2-mg doses of the Syntex norethindrone. Syntex's submission of a fraudulent toxicology analysis of naproxen largely led to the Food and Drug Administration 's uncovering of extensive scientific misconduct by Industrial Bio-Test Laboratories in 1976. Luis E. Miramontes Luis Ernesto Miramontes Cárdenas (March 16, 1925 – September 13, 2004)

1484-724: The United States and outside the United States as well. These student chapters mainly focus on volunteering opportunities, career development, and the discussion of student and faculty research. The organization also publishes textbooks, administers several national chemistry awards, provides grants for scientific research, and supports various educational and outreach activities. The ACS has been criticized for predatory pricing of its products ( SciFinder , journals and other publications), for opposing open access publishing, as well as for initiating numerous copyright enforcement litigations despite its non-profit status and its chartered commitment to dissemination of chemical information. In 1874,

1537-584: The acquisition of the Universal Oil Products laboratory by a consortium of oil companies in 1931. The companies established a trust fund, The Petroleum Research Fund, in 1944 to prevent antitrust litigation tied to their UOP assets. The ACS was named the beneficiary of the trust. The first grants from the PRF were awarded in 1954. In 2000, the trust was transferred to the ACS. The ACS established The American Chemical Society Petroleum Research Fund and

1590-420: The association into closer union, and ensure a better appreciation of our science and its students on the part of the general public." Although Chandler was a likely choice to become the society's first president because of his role in organizing the society, New York University chemistry professor John William Draper was elected as the first president of the society because of his national reputation. Draper

1643-702: The biannual ACS National Meetings, for the purpose of recognizing promising Assistant Professors, talented young researchers, outstanding technical contributions from junior-level chemists, in the field of organic chemistry . The symposia also honor national award winners, including the Arthur C. Cope Award , Cope Scholar Award, James Flack Norris Award in Physical Organic Chemistry, Herbert C. Brown Award for Creative Research in Synthetic Methods. The Division helps to organize symposia at

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1696-607: The campaigns have been celebrated with a yearly theme, such as "Chemistry Colors Our World" (2015) and "Energy: Now and Forever!" (2013). The Green Chemistry Institute (GCI) supports the "implementation of green chemistry and engineering throughout the global chemistry enterprise." The GCI organizes an annual conference, the Green Chemistry and Engineering Conference, provides research grants, administers awards, and provides information and support for green chemistry practices to educators, researchers, and industry. The GCI

1749-591: The classroom, foster the scientific curiosity of our nation's youth and encourage future generations to pursue scientific careers. As of 2009, Clifford and Kathryn Hach donated $ 33 million to ACS, to continue the work of the Hach Scientific Foundation in supporting high school chemistry teaching. The Society sponsors the United States National Chemistry Olympiad (USNCO), a contest used to select

1802-555: The compound". The last step of the synthesis method was registered on page 114 of the Miramontes's personal laboratory notebook (signed). All three Miramontes, Djerassi, and Rosenkranz are listed on the patent as co-inventors. Luis E. Miramontes, Andrés Manuel del Río (discoverer of vanadium ) and Mario Molina , Chemistry Nobel Prize in 1995, are the three most important Mexican chemists of all time. American Chemical Society The American Chemical Society ( ACS )

1855-545: The establishment of the Priestley Medal , the highest award offered by the ACS, which is given for distinguished services to chemistry. The 2019 recipient of the Priestley Medal is K. Barry Sharpless . Additional awards are offered by divisions, local sections and other bodies of ACS. The William H. Nichols Medal Award was the first ACS award to honor outstanding researchers in the field of chemistry. It

1908-498: The exam. The ACS also approves certified undergraduate programs in chemistry. A student who completes the required laboratory and course work—sometimes in excess of what a particular college may require for its Bachelor's degree —is considered by the Society to be well trained for professional work. The ACS coordinates two annual public awareness campaigns, National Chemistry Week and Chemists Celebrate Earth Week, as part of its educational outreach. Since 1978 and 2003 respectively,

1961-560: The exchange of information among scientists who work in particular fields of chemistry or professional interests. Divisional activities include organizing technical sessions at ACS meetings, publishing books and resources, administering awards and lectureships, and conducting other events. The original five divisions were 1) organic chemistry, 2) industrial chemists and chemical engineers, 3) agricultural and food chemistry, 4) fertilizer chemistry, and 5) physical and inorganic chemistry. As of 2016, there are 32 technical divisions of ACS. This

2014-422: The following peer-reviewed journals: In addition to academic journals, ACS Publications also publishes Chemical & Engineering News , a weekly trade magazine covering news in the chemical profession, inChemistry , a magazine for undergraduate students, and ChemMatters , a magazine for high school students and teachers. ACS also created ChemRxiv , which is an open access preprint repository for

2067-509: The four-member team that represents the United States at the International Chemistry Olympiad (IChO). The ACS Division of Chemical Education provides standardized tests for various subfields of chemistry. The two most commonly used tests are the undergraduate-level tests for general and organic chemistry. Each of these tests consists of 70 multiple-choice questions, and gives students 110 minutes to complete

2120-602: The highest honors given by the Chemical Marketing and Economic Group of ACS NY since December 6, 2012. They are presented to leaders of industry, investments, and other sectors, for their contributions to science, technology, engineering and mathematics (STEM) initiatives. Honorees include Andrew N. Liveris (Dow Chemical), P. Roy Vagelos (Regeneron, Merck), Thomas M. Connelly (DuPont) and Juan Pablo del Valle (Mexichem). The ACS also administers regional awards presented annually at regional meetings. This includes

2173-663: The international meeting called Pacifichem and it organizes the biennial National Organic Chemistry Symposium (NOS) which highlights recent advances in organic chemistry and hosts the Roger Adams Award address. The Division also organizes corporate sponsorships to provide fellowships for PhD students and undergraduates. It also organizes the Graduate Research Symposium and manages award and travel grant programs for undergraduates. Local sections were authorized in 1890 and are autonomous units of

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2226-471: The option to pay an upfront fee to enable free online access to their articles. In 2015, the ACS launched the first fully open access journal in the society's history, ACS Central Science . The ACS states that the journal offers the same peer-review standards as its subscription journals, but without publishing charges to either authors or readers. A second open access title, ACS Omega , an interdisciplinary mega journal , launched in 2016. In December 2020,

2279-512: The prestigious Journal of the American Chemical Society , as well as the weekly trade magazine Chemical & Engineering News . The ACS holds national meetings twice a year covering the complete field of chemistry and also holds smaller conferences concentrating on specific chemical fields or geographic regions. The primary source of income of the ACS is the Chemical Abstracts Service , a provider of chemical databases worldwide. The ACS has student chapters in virtually every major university in

2332-711: The previous trust was dissolved. The PRF trust was valued at $ 144.7 million in December 2014. The ACS International Activities is the birthplace of the ACS International Center, an online resource for scientists and engineers looking to study abroad or explore an international career or internship. The site houses information on hundreds of scholarships and grants related to all levels of experience to promote scientific mobility of researchers and practitioners in STEM fields. The Society grants membership to undergraduates as student members provided they can pay

2385-546: The supervision of Carl Djerassi and the direction of George Rosenkranz at Syntex laboratory in Mexico City, Miramontes completed the first ever synthesis of an oral contraceptive: progestin norethisterone. While Djerassi is sometimes regarded as 'Father of the Pill'"., it was Miramontes, working under Djerassi's supervision, that achieved the first synthesis. In the words of Djerassi, "On 15 October 1951, Luis Miramontes,

2438-449: The very thought." The ACS has generally opposed legislation that would mandate free access to scientific journal articles and chemical information. However it has recently launched new open access journals and provided authors with open access publishing options. Nevertheless, the actual percentage of open-access publications in ACS journals is the lowest among the 8 major scientific journal publishers (see figure below): The mid-2000s saw

2491-447: Was a photochemist and pioneering photographer who had produced one of the first photographic portraits in 1840. Chandler would later serve as president in 1881 and 1889. In the ACS logo, originally designed in the early 20th century by Tiffany's Jewelers and used since 1909, a stylized symbol of a kaliapparat is used. The Journal of the American Chemical Society was founded in 1879 to publish original chemical research. It

2544-596: Was a Mexican chemist known as co-inventor and the first to synthesize an oral contraceptive, progestin norethisterone . Miramontes was born in Tepic , Nayarit . He obtained his first Degree in chemical engineering at the Universidad Nacional Autónoma de México (UNAM). He was a founding researcher of the Institute of Chemistry of UNAM, specializing mainly in the area of Organic Chemistry . He

2597-958: Was a professor of the Faculty of Chemistry of UNAM, Director and professor of the School of Chemistry at the Universidad Iberoamericana , and deputy director of research at the Mexican Institute of Petroleum (IMP). Miramontes was a member the American Chemical Society (Emeritus), the Mexican Institute of Chemical Engineers, the National Institute of Chemical and Chemical Engineers, the Chemical Society of Mexico,

2650-762: Was established in 1903 by the ACS New York Section and is named for William H. Nichols , an American chemist and businessman and one of the original founders of ACS. Of the over 100 Nichols Medalists, 16 have subsequently been awarded the Nobel Prize in Chemistry . The Willard Gibbs Award , granted by the ACS Chicago Section, was established in 1910 in honor of Josiah Willard Gibbs , the Yale University professor who formulated

2703-761: Was founded in 1997 as an independent non-profit organization, by chemists Joe Breen and Dennis Hjeresen in cooperation with the Environmental Protection Agency . In 2001, the GCI became a part of the American Chemical Society. [1] The Petroleum Research Fund (PRF) is an endowment fund administered by the ACS that supports advanced education and fundamental research in the petroleum and fossil fuel fields at non-profit institutions. Several categories of grants are offered for various career levels and institutions. The fund awarded more than $ 25 million in grants in 2007. The PRF traces its origins to

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2756-528: Was the first journal published by ACS and is still the society's flagship peer-reviewed publication. In 1907, Chemical Abstracts was established as a separate journal (it previously appeared within JACS), which later became the Chemical Abstracts Service , a division of ACS that provides chemical information to researchers and others worldwide. Chemical & Engineering News is a weekly trade magazine that has been published by ACS since 1923. The society adopted

2809-479: Was the most active, orally-effective progestational hormone of its time. Syntex submitted a patent application in November 1951. In August 1953, G.D. Searle & Co. filed for a patent for the synthesis of the double-bond isomer 13 of norethindrone called noretynodrel . Noretynodrel is converted into norethisterone under acidic conditions, such as those in the human stomach , and the new patent did not infringe on

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