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113-469: The word "syringe" is derived from the Greek σῦριγξ ( syrinx , meaning "Pan flute", "tube"). Sectors in the syringe and needle market include disposable and safety syringes , injection pens, needleless injectors, insulin pumps, and specialty needles. Hypodermic syringes are used with hypodermic needles to inject liquid or gases into body tissues, or to remove from the body . Injecting of air into

226-410: A blood vessel is hazardous, as it may cause an air embolism ; preventing embolisms by removing air from the syringe is one of the reasons for the familiar image of holding a hypodermic syringe pointing upward, tapping it, and expelling a small amount of liquid before an injection into the bloodstream . The barrel of a syringe is made of plastic or glass , usually has graduated marks indicating

339-473: A molecular mass of 5808 Da . The molecular formula of human insulin is C 257 H 383 N 65 O 77 S 6 . It is a combination of two peptide chains ( dimer ) named an A-chain and a B-chain, which are linked together by two disulfide bonds . The A-chain is composed of 21 amino acids, while the B-chain consists of 30 residues. The linking (interchain) disulfide bonds are formed at cysteine residues between

452-408: A 110 amino acid-long protein called "preproinsulin". Preproinsulin is translated directly into the rough endoplasmic reticulum (RER), where its signal peptide is removed by signal peptidase to form "proinsulin". As the proinsulin folds , opposite ends of the protein, called the "A-chain" and the "B-chain", are fused together with three disulfide bonds . Folded proinsulin then transits through

565-724: A basic health system . Insulin may have originated more than a billion years ago. The molecular origins of insulin go at least as far back as the simplest unicellular eukaryotes . Apart from animals, insulin-like proteins are also known to exist in fungi and protists . Insulin is produced by beta cells of the pancreatic islets in most vertebrates and by the Brockmann body in some teleost fish . Cone snails : Conus geographus and Conus tulipa , venomous sea snails that hunt small fish, use modified forms of insulin in their venom cocktails. The insulin toxin, closer in structure to fishes' than to snails' native insulin, slows down

678-577: A basis for coinages: anthropology , photography , telephony , isomer , biomechanics , cinematography , etc. Together with Latin words , they form the foundation of international scientific and technical vocabulary ; for example, all words ending in -logy ('discourse'). There are many English words of Greek origin . Greek is an independent branch of the Indo-European language family. The ancient language most closely related to it may be ancient Macedonian , which, by most accounts,

791-558: A fairly stable set of consonantal contrasts . The main phonological changes occurred during the Hellenistic and Roman period (see Koine Greek phonology for details): In all its stages, the morphology of Greek shows an extensive set of productive derivational affixes , a limited but productive system of compounding and a rich inflectional system. Although its morphological categories have been fairly stable over time, morphological changes are present throughout, particularly in

904-560: A faster, more convenient cursive writing style with the use of ink and quill . The Greek alphabet consists of 24 letters, each with an uppercase ( majuscule ) and lowercase ( minuscule ) form. The letter sigma has an additional lowercase form (ς) used in the final position of a word: In addition to the letters, the Greek alphabet features a number of diacritical signs : three different accent marks ( acute , grave , and circumflex ), originally denoting different shapes of pitch accent on

1017-406: A filling. These are not used much in human medicine because of the risk of cross-infection via the needle. An exception is the personal insulin autoinjector used by diabetic patients and in dual-chambered syringe designs intended to deliver a prefilled saline flush solution after the medication. Venom extraction syringes are different from standard syringes, because they usually do not puncture

1130-540: A foreign language. It is also often stated that the historical changes have been relatively slight compared with some other languages. According to one estimation, " Homeric Greek is probably closer to Demotic than 12-century Middle English is to modern spoken English ". Greek is spoken today by at least 13 million people, principally in Greece and Cyprus along with a sizable Greek-speaking minority in Albania near

1243-417: A glucose load (75 or 100 g of glucose), followed by a slow drop over the next 100 minutes, to remain above 120 mg/100 mL after two hours after the start of the test. In a normal person the blood glucose level is corrected (and may even be slightly over-corrected) by the end of the test. An insulin spike is a 'first response' to blood glucose increase, this response is individual and dose specific although it

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1356-424: A risk of the contents of the syringes leaching plasticizers from the syringe material. Non-disposable glass syringes may be preferred where this is a problem. Glass syringes may also be preferred where a very high degree of precision is important (i.e. quantitative chemical analysis ), because their engineering tolerances are lower and the plungers move more smoothly. In these applications, the transfer of pathogens

1469-470: A rubber cap. The dentist places the cartridge directly into a stainless steel syringe, with a double-pointed (single-use) needle. The tip placed on the cartridge side punctures the capsule and the piston will push the product. There is therefore no contact between the product and the ambient air during use. The ancillary tool (generally part of a dental engine ) used to supply water, compressed air or mist (formed by combination of water and compressed air) to

1582-410: A sealed cartridge system under the registered trademark Carpule. The current trademark owner is Kulzer Dental GmbH . The carpules have long been reserved for anesthetic products for dental use. It is practically a bottomless flask. The latter is replaced by an elastomer plug that can slide in the body of the cartridge. This plug will be pushed by the plunger of the syringe. The neck is closed with

1695-448: A transcription factor for MafA in an unknown manner and MafA is transported out of the cell. MafA is then translocated back into the nucleus where it binds the C1 element of the insulin promoter. These transcription factors work synergistically and in a complex arrangement. Increased blood glucose can after a while destroy the binding capacities of these proteins, and therefore reduce

1808-416: Is strongly conserved and varies only slightly between species. Bovine insulin differs from human in only three amino acid residues, and porcine insulin in one. Even insulin from some species of fish is similar enough to human to be clinically effective in humans. Insulin in some invertebrates is quite similar in sequence to human insulin, and has similar physiological effects. The strong homology seen in

1921-399: Is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin ( INS) gene . It is the main anabolic hormone of the body. It regulates the metabolism of carbohydrates , fats , and protein by promoting the absorption of glucose from the blood into cells of the liver , fat , and skeletal muscles . In these tissues the absorbed glucose

2034-804: Is also found in Bulgaria near the Greek-Bulgarian border. Greek is also spoken worldwide by the sizable Greek diaspora which has notable communities in the United States , Australia , Canada , South Africa , Chile , Brazil , Argentina , Russia , Ukraine , the United Kingdom , and throughout the European Union , especially in Germany . Historically, significant Greek-speaking communities and regions were found throughout

2147-546: Is also regulated by glucose: high glucose promotes insulin production while low glucose levels lead to lower production. Insulin enhances glucose uptake and metabolism in the cells, thereby reducing blood sugar. Their neighboring alpha cells , by taking their cues from the beta cells, secrete glucagon into the blood in the opposite manner: increased secretion when blood glucose is low, and decreased secretion when glucose concentrations are high. Glucagon increases blood glucose by stimulating glycogenolysis and gluconeogenesis in

2260-773: Is an Indo-European language, constituting an independent Hellenic branch within the Indo-European language family. It is native to Greece , Cyprus , Italy (in Calabria and Salento ), southern Albania , and other regions of the Balkans , Caucasus , the Black Sea coast, Asia Minor , and the Eastern Mediterranean . It has the longest documented history of any Indo-European language, spanning at least 3,400 years of written records. Its writing system

2373-479: Is an Indo-European language, but also includes a number of borrowings from the languages of the populations that inhabited Greece before the arrival of Proto-Greeks, some documented in Mycenaean texts ; they include a large number of Greek toponyms . The form and meaning of many words have changed. Loanwords (words of foreign origin) have entered the language, mainly from Latin, Venetian , and Turkish . During

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2486-486: Is as follows: This is the primary mechanism for release of insulin. Other substances known to stimulate insulin release include the amino acids arginine and leucine, parasympathetic release of acetylcholine (acting via the phospholipase C pathway), sulfonylurea , cholecystokinin (CCK, also via phospholipase C), and the gastrointestinally derived incretins , such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). Release of insulin

2599-699: Is characterized by increased glucagon secretion which is unaffected by, and unresponsive to the concentration of blood glucose. But insulin is still secreted into the blood in response to the blood glucose. As a result, glucose accumulates in the blood. The human insulin protein is composed of 51 amino acids , and has a molecular mass of 5808 Da . It is a hetero dimer of an A-chain and a B-chain, which are linked together by disulfide bonds . Insulin's structure varies slightly between species of animals. Insulin from non-human animal sources differs somewhat in effectiveness (in carbohydrate metabolism effects) from human insulin because of these variations. Porcine insulin

2712-404: Is converted into either glycogen , via glycogenesis , or fats ( triglycerides ), via lipogenesis ; in the liver, glucose is converted into both. Glucose production and secretion by the liver are strongly inhibited by high concentrations of insulin in the blood. Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. It is thus an anabolic hormone, promoting

2825-504: Is especially close to the human version, and was widely used to treat type 1 diabetics before human insulin could be produced in large quantities by recombinant DNA technologies. Insulin was the first peptide hormone discovered. Frederick Banting and Charles Best , working in the laboratory of John Macleod at the University of Toronto , were the first to isolate insulin from dog pancreas in 1921. Frederick Sanger sequenced

2938-492: Is far more stable than the monomer, which is desirable for practical reasons; however, the monomer is a much faster-reacting drug because diffusion rate is inversely related to particle size. A fast-reacting drug means insulin injections do not have to precede mealtimes by hours, which in turn gives people with diabetes more flexibility in their daily schedules. Insulin can aggregate and form fibrillar interdigitated beta-sheets . This can cause injection amyloidosis , and prevents

3051-399: Is inhibition due to dominance of the α-adrenergic receptors. When the glucose level comes down to the usual physiologic value, insulin release from the β-cells slows or stops. If the blood glucose level drops lower than this, especially to dangerously low levels, release of hyperglycemic hormones (most prominently glucagon from islet of Langerhans alpha cells) forces release of glucose into

3164-415: Is known as a homodimer. Insulin binds to the α-subunits of the homodimer, which faces the extracellular side of the cells. The β subunits have tyrosine kinase enzyme activity which is triggered by the insulin binding. This activity provokes the autophosphorylation of the β subunits and subsequently the phosphorylation of proteins inside the cell known as insulin receptor substrates (IRS). The phosphorylation of

3277-453: Is located in the nuclear periphery as a result of interaction with HDAC1 and 2 , which results in downregulation of insulin secretion. An increase in blood glucose levels causes phosphorylation of PDX1 , which leads it to undergo nuclear translocation and bind the A3 element within the insulin promoter. Upon translocation it interacts with coactivators HAT p300 and SETD7 . PDX1 affects

3390-460: Is missing an intron ( Ins1 ). Transcription of the insulin gene increases in response to elevated blood glucose. This is primarily controlled by transcription factors that bind enhancer sequences in the ~400 base pairs before the gene's transcription start site. The major transcription factors influencing insulin secretion are PDX1 , NeuroD1 , and MafA . During a low-glucose state, PDX1 (pancreatic and duodenal homeobox protein 1)

3503-533: Is packaged inside mature granules waiting for metabolic signals (such as leucine, arginine, glucose and mannose) and vagal nerve stimulation to be exocytosed from the cell into the circulation. Insulin and its related proteins have been shown to be produced inside the brain, and reduced levels of these proteins are linked to Alzheimer's disease. Insulin release is stimulated also by beta-2 receptor stimulation and inhibited by alpha-1 receptor stimulation. In addition, cortisol, glucagon and growth hormone antagonize

Syringe - Misplaced Pages Continue

3616-519: Is protected and promoted officially as a regional and minority language in Armenia, Hungary , Romania, and Ukraine. It is recognized as a minority language and protected in Turkey by the 1923 Treaty of Lausanne . The phonology , morphology , syntax , and vocabulary of the language show both conservative and innovative tendencies across the entire attestation of the language from the ancient to

3729-3105: Is sometimes called aljamiado , as when Romance languages are written in the Arabic alphabet. Article 1 of the Universal Declaration of Human Rights in Greek: Transcription of the example text into Latin alphabet : Article 1 of the Universal Declaration of Human Rights in English: Proto-Greek Mycenaean Ancient Koine Medieval Modern Insulin 1A7F , 1AI0 , 1AIY , 1B9E , 1BEN , 1EV3 , 1EV6 , 1EVR , 1FU2 , 1FUB , 1G7A , 1G7B , 1GUJ , 1HIQ , 1HIS , 1HIT , 1HLS , 1HTV , 1HUI , 1IOG , 1IOH , 1J73 , 1JCA , 1JCO , 1K3M , 1KMF , 1LKQ , 1LPH , 1MHI , 1MHJ , 1MSO , 1OS3 , 1OS4 , 1Q4V , 1QIY , 1QIZ , 1QJ0 , 1RWE , 1SF1 , 1T1K , 1T1P , 1T1Q , 1TRZ , 1TYL , 1TYM , 1UZ9 , 1VKT , 1W8P , 1XDA , 1XGL , 1XW7 , 1ZEG , 1ZEH , 1ZNJ , 2AIY , 2C8Q , 2C8R , 2CEU , 2H67 , 2HH4 , 2HHO , 2HIU , 2JMN , 2JUM , 2JUU , 2JUV , 2JV1 , 2JZQ , 2K91 , 2K9R , 2KJJ , 2KJU , 2KQQ , 2KXK , 2L1Y , 2L1Z , 2LGB , 2M1D , 2M1E , 2M2M , 2M2N , 2M2O , 2M2P , 2OLY , 2OLZ , 2OM0 , 2OM1 , 2OMG , 2OMH , 2OMI , 2QIU , 2R34 , 2R35 , 2R36 , 2RN5 , 2VJZ , 2VK0 , 2W44 , 2WBY , 2WC0 , 2WRU , 2WRV , 2WRW , 2WRX , 2WS0 , 2WS1 , 2WS4 , 2WS6 , 2WS7 , 3AIY , 3BXQ , 3E7Y , 3E7Z , 3EXX , 3FQ9 , 3I3Z , 3I40 , 3ILG , 3INC , 3IR0 , 3Q6E , 3ROV , 3TT8 , 3U4N , 3UTQ , 3UTS , 3UTT , 3V19 , 3V1G , 3W11 , 3W12 , 3W13 , 3W7Y , 3W7Z , 3W80 , 3ZI3 , 3ZQR , 3ZS2 , 3ZU1 , 4AIY , 4AJX , 4AJZ , 4AK0 , 4AKJ , 4EFX , 4EWW , 4EWX , 4EWZ , 4EX0 , 4EX1 , 4EXX , 4EY1 , 4EY9 , 4EYD , 4EYN , 4EYP , 4F0N , 4F0O , 4F1A , 4F1B , 4F1C , 4F1D , 4F1F , 4F1G , 4F4T , 4F4V , 4F51 , 4F8F , 4FG3 , 4FKA , 4GBC , 4GBI , 4GBK , 4GBL , 4GBN , 4IUZ , 5AIY , 2LWZ , 3JSD , 3KQ6 , 3P2X , 3P33 , 1JK8 , 2MLI , 2MPG , 2MPI , 2MVC , 2MVD , 4CXL , 4CXN , 4CY7 , 4NIB , 4OGA , 4P65 , 4Q5Z , 4RXW , 4UNE , 4UNG , 4UNH , 4XC4 , 4WDI , 4Z76 , 4Z77 , 4Z78 , 2N2W , 5CO6 , 5ENA , 4Y19 , 5BQQ , 5BOQ , 2N2V , 5CNY , 5CO9 , 5EN9 , 4Y1A , 2N2X , 5BPO , 5CO2 , 5BTS , 5HYJ , 5C0D ,%%s 1EFE , 1SJT , 1SJU , 2KQP ,%%s 1T0C ,%%s 2G54 , 2G56 , 3HYD , 2OMQ 3630 16334 ENSG00000254647 ENSMUSG00000000215 P01308 P01326 NM_000207 NM_001185097 NM_001185098 NM_001291897 NM_001185083 NM_001185084 NM_008387 NP_001172026.1 NP_001172027.1 NP_001278826.1 NP_000198 NP_000198 NP_000198 NP_000198 NP_001172012 NP_001172013 NP_032413 Insulin ( / ˈ ɪ n . sj ʊ . l ɪ n / , from Latin insula , 'island')

3842-475: Is spoken by at least 13.5 million people today in Greece, Cyprus, Italy, Albania, Turkey , and the many other countries of the Greek diaspora . Greek roots have been widely used for centuries and continue to be widely used to coin new words in other languages; Greek and Latin are the predominant sources of international scientific vocabulary . Greek has been spoken in the Balkan peninsula since around

3955-402: Is still unsafe as it can introduce bacteria from the skin into the bloodstream and cause serious and sometimes lethal infections. In medical settings, single-use needles and syringes effectively reduce the risk of cross-contamination. Medical syringes are sometimes used without a needle for orally administering liquid medicines to young children or animals, or milk to small young animals, because

4068-763: Is still used internationally for the writing of Ancient Greek . In Greek, the question mark is written as the English semicolon, while the functions of the colon and semicolon are performed by a raised point (•), known as the ano teleia ( άνω τελεία ). In Greek the comma also functions as a silent letter in a handful of Greek words, principally distinguishing ό,τι ( ó,ti , 'whatever') from ότι ( óti , 'that'). Ancient Greek texts often used scriptio continua ('continuous writing'), which means that ancient authors and scribes would write word after word with no spaces or punctuation between words to differentiate or mark boundaries. Boustrophedon , or bi-directional text,

4181-494: Is strongly inhibited by norepinephrine (noradrenaline), which leads to increased blood glucose levels during stress. It appears that release of catecholamines by the sympathetic nervous system has conflicting influences on insulin release by beta cells, because insulin release is inhibited by α 2 -adrenergic receptors and stimulated by β 2 -adrenergic receptors. The net effect of norepinephrine from sympathetic nerves and epinephrine from adrenal glands on insulin release

4294-414: Is such that 1 mL of insulin fluid has 100 standard "units" of insulin. Since insulin vials are typically 10 mL, each vial has 1000 units. Insulin syringes are made specifically for self injections and have friendly features: U-100 syringe sizes and markings There are needle syringes designed to reload from a built-in tank (container) after each injection, so they can make several or many injections on

4407-650: Is the Greek alphabet , which has been used for approximately 2,800 years; previously, Greek was recorded in writing systems such as Linear B and the Cypriot syllabary . The alphabet arose from the Phoenician script and was in turn the basis of the Latin , Cyrillic , Coptic , Gothic , and many other writing systems. The Greek language holds a very important place in the history of the Western world. Beginning with

4520-418: Is the presence of zinc atoms (Zn ) on the axis of symmetry, which are surrounded by three water molecules and three histidine residues at position B10. The hexamer is an inactive form with long-term stability, which serves as a way to keep the highly reactive insulin protected, yet readily available. The hexamer-monomer conversion is one of the central aspects of insulin formulations for injection. The hexamer

4633-506: Is to use the needle tip to add liquids to very confined spaces, such as washing out some scientific apparatus. They are often used for measuring and transferring solvents and reagents where a high precision is not required. Alternatively, microliter syringes can be used to measure and dose chemicals very precisely by using a small diameter capillary as the syringe barrel. The polyethylene construction of these disposable syringes usually makes them rather chemically resistant. There is, however,

Syringe - Misplaced Pages Continue

4746-411: Is typically purple in colour to distinguish it from a standard injection syringe with a luer tip. The sizes most commonly used are 1 mL, 2.5 mL, 3 mL, 5 mL and 10 mL. A dental syringe is used by dentists for the injection of an anesthetic . It consists of a breech-loading syringe fitted with a sealed cartridge containing an anesthetic solution. In 1928, Bayer Dental developed, coined and produced

4859-490: Is usually not an issue. Used with a long needle or cannula , syringes are also useful for transferring fluids through rubber septa when atmospheric oxygen or moisture are being excluded. Examples include the transfer of air-sensitive or pyrophoric reagents such as phenylmagnesium bromide and n -butyllithium respectively. Glass syringes are also used to inject small samples for gas chromatography (1 μl) and mass spectrometry (10 μl). Syringe drivers may be used with

4972-486: The COVID-19 pandemic as vaccines were in short supply. In some jurisdictions, the sale or possession of hypodermic syringes may be controlled or prohibited without a prescription, due to its potential use with illegal intravenous drugs . The syringe has many non-medical applications. Medical-grade disposable hypodermic syringes are often used in research laboratories for convenience and low cost. Another application

5085-495: The Eastern Mediterranean , in what are today Southern Italy , Turkey , Cyprus , Syria , Lebanon , Israel , Palestine , Egypt , and Libya ; in the area of the Black Sea , in what are today Turkey, Bulgaria , Romania , Ukraine , Russia , Georgia , Armenia , and Azerbaijan ; and, to a lesser extent, in the Western Mediterranean in and around colonies such as Massalia , Monoikos , and Mainake . It

5198-563: The Golgi apparatus and is packaged into specialized secretory vesicles . In the granule, proinsulin is cleaved by proprotein convertase 1/3 and proprotein convertase 2 , removing the middle part of the protein, called the " C-peptide ". Finally, carboxypeptidase E removes two pairs of amino acids from the protein's ends, resulting in active insulin – the insulin A- and B- chains, now connected with two disulfide bonds. The resulting mature insulin

5311-516: The Indo-Iranian languages (see Graeco-Aryan ), but little definitive evidence has been found. In addition, Albanian has also been considered somewhat related to Greek and Armenian, and it has been proposed that they all form a higher-order subgroup along with other extinct languages of the ancient Balkans; this higher-order subgroup is usually termed Palaeo-Balkan , and Greek has a central position in it. Linear B , attested as early as

5424-457: The histone modifications through acetylation and deacetylation as well as methylation . It is also said to suppress glucagon . NeuroD1 , also known as β2, regulates insulin exocytosis in pancreatic β cells by directly inducing the expression of genes involved in exocytosis. It is localized in the cytosol , but in response to high glucose it becomes glycosylated by OGT and/or phosphorylated by ERK , which causes translocation to

5537-492: The nominal and verbal systems. The major change in the nominal morphology since the classical stage was the disuse of the dative case (its functions being largely taken over by the genitive ). The verbal system has lost the infinitive , the synthetically -formed future, and perfect tenses and the optative mood . Many have been replaced by periphrastic ( analytical ) forms. Pronouns show distinctions in person (1st, 2nd, and 3rd), number (singular, dual , and plural in

5650-470: The 3rd millennium BC, or possibly earlier. The earliest written evidence is a Linear B clay tablet found in Messenia that dates to between 1450 and 1350 BC, making Greek the world's oldest recorded living language . Among the Indo-European languages, its date of earliest written attestation is matched only by the now-extinct Anatolian languages . The Greek language is conventionally divided into

5763-486: The Greek alphabet since approximately the 9th century BC. It was created by modifying the Phoenician alphabet , with the innovation of adopting certain letters to represent the vowels. The variant of the alphabet in use today is essentially the late Ionic variant, introduced for writing classical Attic in 403 BC. In classical Greek, as in classical Latin, only upper-case letters existed. The lower-case Greek letters were developed much later by medieval scribes to permit

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5876-425: The Greek language are often emphasized. Although Greek has undergone morphological and phonological changes comparable to those seen in other languages, never since classical antiquity has its cultural, literary, and orthographic tradition been interrupted to the extent that one can speak of a new language emerging. Greek speakers today still tend to regard literary works of ancient Greek as part of their own rather than

5989-495: The Greek language was the Cypriot syllabary (also a descendant of Linear A via the intermediate Cypro-Minoan syllabary ), which is closely related to Linear B but uses somewhat different syllabic conventions to represent phoneme sequences. The Cypriot syllabary is attested in Cyprus from the 11th century BC until its gradual abandonment in the late Classical period, in favor of the standard Greek alphabet. Greek has been written in

6102-629: The Greek verb have likewise remained largely the same over the course of the language's history but with significant changes in the number of distinctions within each category and their morphological expression. Greek verbs have synthetic inflectional forms for: Many aspects of the syntax of Greek have remained constant: verbs agree with their subject only, the use of the surviving cases is largely intact (nominative for subjects and predicates, accusative for objects of most verbs and many prepositions, genitive for possessors), articles precede nouns, adpositions are largely prepositional, relative clauses follow

6215-685: The Greek-Albanian border. A significant percentage of Albania's population has knowledge of the Greek language due in part to the Albanian wave of immigration to Greece in the 1980s and '90s and the Greek community in the country. Prior to the Greco-Turkish War and the resulting population exchange in 1923 a very large population of Greek-speakers also existed in Turkey , though very few remain today. A small Greek-speaking community

6328-533: The IRS activates a signal transduction cascade that leads to the activation of other kinases as well as transcription factors that mediate the intracellular effects of insulin. The cascade that leads to the insertion of GLUT4 glucose transporters into the cell membranes of muscle and fat cells, and to the synthesis of glycogen in liver and muscle tissue, as well as the conversion of glucose into triglycerides in liver, adipose, and lactating mammary gland tissue, operates via

6441-464: The UK and Ireland, manually operated hand syringes are used to inject lidocaine into patients' gums. A dose-sparing syringe is one which minimises the amount of liquid remaining in the barrel after the plunger has been depressed. These syringes feature a combined needle and syringe, and a protrusion on the face of the plunger to expel liquid from the needle hub. Such syringes were particularly popular during

6554-404: The actions of insulin during times of stress. Insulin also inhibits fatty acid release by hormone-sensitive lipase in adipose tissue. Contrary to an initial belief that hormones would be generally small chemical molecules, as the first peptide hormone known of its structure, insulin was found to be quite large. A single protein (monomer) of human insulin is composed of 51 amino acids , and has

6667-487: The activation, by IRS-1, of phosphoinositol 3 kinase ( PI3K ). This enzyme converts a phospholipid in the cell membrane by the name of phosphatidylinositol 4,5-bisphosphate (PIP2), into phosphatidylinositol 3,4,5-triphosphate (PIP3), which, in turn, activates protein kinase B (PKB). Activated PKB facilitates the fusion of GLUT4 containing endosomes with the cell membrane, resulting in an increase in GLUT4 transporters in

6780-404: The acute during the late 20th century, and it has only been retained in typography . After the writing reform of 1982, most diacritics are no longer used. Since then, Greek has been written mostly in the simplified monotonic orthography (or monotonic system), which employs only the acute accent and the diaeresis. The traditional system, now called the polytonic orthography (or polytonic system),

6893-459: The acute thermoregulatory and glucoregulatory response to food intake, suggesting that central nervous insulin contributes to the co-ordination of a wide variety of homeostatic or regulatory processes in the human body. Insulin also has stimulatory effects on gonadotropin-releasing hormone from the hypothalamus , thus favoring fertility . Once an insulin molecule has docked onto the receptor and effected its action, it may be released back into

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7006-462: The amino acid structure in 1951, which made insulin the first protein to be fully sequenced. The crystal structure of insulin in the solid state was determined by Dorothy Hodgkin in 1969. Insulin is also the first protein to be chemically synthesised and produced by DNA recombinant technology . It is on the WHO Model List of Essential Medicines , the most important medications needed in

7119-403: The amount of insulin secreted, causing diabetes . The decreased binding activities can be mediated by glucose induced oxidative stress and antioxidants are said to prevent the decreased insulin secretion in glucotoxic pancreatic β cells . Stress signalling molecules and reactive oxygen species inhibits the insulin gene by interfering with the cofactors binding the transcription factors and

7232-402: The ancient language; singular and plural alone in later stages), and gender (masculine, feminine, and neuter), and decline for case (from six cases in the earliest forms attested to four in the modern language). Nouns, articles, and adjectives show all the distinctions except for a person. Both attributive and predicative adjectives agree with the noun. The inflectional categories of

7345-677: The barrel. Such facilitates easy disassembly and cleaning. Syringes are used to refill ink cartridges with ink in fountain pens . Common workshop applications include injecting glue into tight spots to repair joints where disassembly is impractical or impossible; and injecting lubricants onto working surfaces without spilling. Sometimes a large hypodermic syringe is used without a needle for very small baby mammals to suckle from in artificial rearing. Historically, large pumps that use reciprocating motion to pump water were referred to as syringes. Pumps of this type were used as early firefighting equipment. There are fountain syringes where

7458-415: The blood from the liver glycogen stores, supplemented by gluconeogenesis if the glycogen stores become depleted. By increasing blood glucose, the hyperglycemic hormones prevent or correct life-threatening hypoglycemia. Evidence of impaired first-phase insulin release can be seen in the glucose tolerance test , demonstrated by a substantially elevated blood glucose level at 30 minutes after the ingestion of

7571-517: The blood. In type 2 diabetes , the destruction of beta cells is less pronounced than in type 1, and is not due to an autoimmune process. Instead, there is an accumulation of amyloid in the pancreatic islets, which likely disrupts their anatomy and physiology. The pathogenesis of type 2 diabetes is not well understood but reduced population of islet beta-cells, reduced secretory function of islet beta-cells that survive, and peripheral tissue insulin resistance are known to be involved. Type 2 diabetes

7684-417: The conversion of small molecules in the blood into large molecules in the cells. Low insulin in the blood has the opposite effect, promoting widespread catabolism , especially of reserve body fat . Beta cells are sensitive to blood sugar levels so that they secrete insulin into the blood in response to high level of glucose, and inhibit secretion of insulin when glucose levels are low. Insulin production

7797-503: The dose can be measured accurately and it is easier to squirt the medicine into the subject's mouth instead of coaxing the subject to drink out of a measuring spoon. Syringes come with a number of designs for the area in which the blade locks to the syringe body. Perhaps the most well known of these is the Luer lock , which simply twists the two together. Bodies featuring a small, plain connection are known as slip tips and are useful for when

7910-404: The early 19th century that was used for literary and official purposes in the newly formed Greek state. In 1976, Dimotiki was declared the official language of Greece, after having incorporated features of Katharevousa and thus giving birth to Standard Modern Greek , used today for all official purposes and in education . The historical unity and continuing identity between the various stages of

8023-420: The end of the syringe is not in the centre of the syringe but at the side. This causes the blade attached to the syringe to lie almost in line with the walls of the syringe itself and they are used when the blade needs to get very close to parallel with the skin (when injecting into a surface vein or artery for example). Syringes for insulin users are designed for standard U-100 insulin. The dilution of insulin

8136-429: The enzymes controlling the rate of glycolysis leading to the synthesis of fats via malonyl-CoA in the tissues that can generate triglycerides , and also the enzymes that control the rate of gluconeogenesis in the liver. The overall effect of these final enzyme dephosphorylations is that, in the tissues that can carry out these reactions, glycogen and fat synthesis from glucose are stimulated, and glucose production by

8249-618: The epics of Homer , ancient Greek literature includes many works of lasting importance in the European canon . Greek is also the language in which many of the foundational texts in science and philosophy were originally composed. The New Testament of the Christian Bible was also originally written in Greek. Together with the Latin texts and traditions of the Roman world , the Greek texts and Greek societies of antiquity constitute

8362-456: The extracellular environment, or it may be degraded by the cell. The two primary sites for insulin clearance are the liver and the kidney. It is broken down by the enzyme, protein-disulfide reductase (glutathione) , which breaks the disulphide bonds between the A and B chains. The liver clears most insulin during first-pass transit, whereas the kidney clears most of the insulin in systemic circulation. Degradation normally involves endocytosis of

8475-430: The first phase of insulin exocytosis, most of the granules predispose for exocytosis are released after the calcium internalization. This pool is known as Readily Releasable Pool (RRP). The RRP granules represent 0.3-0.7% of the total insulin-containing granule population, and they are found immediately adjacent to the plasma membrane. During the second phase of exocytosis, insulin granules require mobilization of granules to

8588-452: The following periods: In the modern era, the Greek language entered a state of diglossia : the coexistence of vernacular and archaizing written forms of the language. What came to be known as the Greek language question was a polarization between two competing varieties of Modern Greek: Dimotiki , the vernacular form of Modern Greek proper, and Katharevousa , meaning 'purified', a compromise between Dimotiki and Ancient Greek developed in

8701-408: The global human metabolism level include: The actions of insulin (indirect and direct) on cells include: Insulin also influences other body functions, such as vascular compliance and cognition . Once insulin enters the human brain, it enhances learning and memory and benefits verbal memory in particular. Enhancing brain insulin signaling by means of intranasal insulin administration also enhances

8814-439: The infinitive entirely (employing a raft of new periphrastic constructions instead) and uses participles more restrictively. The loss of the dative led to a rise of prepositional indirect objects (and the use of the genitive to directly mark these as well). Ancient Greek tended to be verb-final, but neutral word order in the modern language is VSO or SVO. Modern Greek inherits most of its vocabulary from Ancient Greek, which in turn

8927-518: The insulin sequence of diverse species suggests that it has been conserved across much of animal evolutionary history. The C-peptide of proinsulin , however, differs much more among species; it is also a hormone, but a secondary one. Insulin is produced and stored in the body as a hexamer (a unit of six insulin molecules), while the active form is the monomer. The hexamer is about 36000 Da in size. The six molecules are linked together as three dimeric units to form symmetrical molecule. An important feature

9040-467: The late 15th century BC, was the first script used to write Greek. It is basically a syllabary , which was finally deciphered by Michael Ventris and John Chadwick in the 1950s (its precursor, Linear A , has not been deciphered and most likely encodes a non-Greek language). The language of the Linear B texts, Mycenaean Greek , is the earliest known form of Greek. Another similar system used to write

9153-607: The liquid is in a bag or can and goes to the nozzle via a pipe. In earlier times, clyster syringes were used for that purpose. Loose snus is often applied using modified syringes. The nozzle is removed so the opening is the width of the chamber. The snus can be packed tightly into the chamber and plunged into the upper lip. Syringes, called portioners, are also manufactured for this particular purpose. Greek language Greek ( Modern Greek : Ελληνικά , romanized :  Elliniká , [eliniˈka] ; Ancient Greek : Ἑλληνική , romanized :  Hellēnikḗ )

9266-428: The liver in extracting insulin from the blood. This oscillation is important to consider when administering insulin-stimulating medication, since it is the oscillating blood concentration of insulin release, which should, ideally, be achieved, not a constant high concentration. This may be achieved by delivering insulin rhythmically to the portal vein , by light activated delivery, or by islet cell transplantation to

9379-413: The liver through glycogenolysis and gluconeogenesis are inhibited. The breakdown of triglycerides by adipose tissue into free fatty acids and glycerol is also inhibited. After the intracellular signal that resulted from the binding of insulin to its receptor has been produced, termination of signaling is then needed. As mentioned below in the section on degradation, endocytosis and degradation of

9492-465: The liver. The blood insulin level can be measured in international units , such as μIU/mL or in molar concentration , such as pmol/L, where 1 μIU/mL equals 6.945 pmol/L. A typical blood level between meals is 8–11 μIU/mL (57–79 pmol/L). The effects of insulin are initiated by its binding to a receptor, the insulin receptor (IR) , present in the cell membrane. The receptor molecule contains an α- and β subunits. Two molecules are joined to form what

9605-464: The liver. The secretion of insulin and glucagon into the blood in response to the blood glucose concentration is the primary mechanism of glucose homeostasis . Decreased or absent insulin activity results in diabetes , a condition of high blood sugar level ( hyperglycaemia ). There are two types of the disease. In type 1 diabetes , the beta cells are destroyed by an autoimmune reaction so that insulin can no longer be synthesized or be secreted into

9718-640: The membership of Greece and Cyprus in the European Union, Greek is one of the organization's 24 official languages . Greek is recognized as a minority language in Albania, and used co-officially in some of its municipalities, in the districts of Gjirokastër and Sarandë . It is also an official minority language in the regions of Apulia and Calabria in Italy. In the framework of the European Charter for Regional or Minority Languages , Greek

9831-441: The modern period. The division into conventional periods is, as with all such periodizations, relatively arbitrary, especially because, in all periods, Ancient Greek has enjoyed high prestige, and the literate borrowed heavily from it. Across its history, the syllabic structure of Greek has varied little: Greek shows a mixed syllable structure, permitting complex syllabic onsets but very restricted codas. It has only oral vowels and

9944-399: The noun they modify and relative pronouns are clause-initial. However, the morphological changes also have their counterparts in the syntax, and there are also significant differences between the syntax of the ancient and that of the modern form of the language . Ancient Greek made great use of participial constructions and of constructions involving the infinitive, and the modern variety lacks

10057-471: The nucleus. In the nucleus β2 heterodimerizes with E47 , binds to the E1 element of the insulin promoter and recruits co-activator p300 which acetylates β2. It is able to interact with other transcription factors as well in activation of the insulin gene. MafA is degraded by proteasomes upon low blood glucose levels. Increased levels of glucose make an unknown protein glycosylated . This protein works as

10170-536: The objects of study of the discipline of Classics . During antiquity , Greek was by far the most widely spoken lingua franca in the Mediterranean world . It eventually became the official language of the Byzantine Empire and developed into Medieval Greek . In its modern form , Greek is the official language of Greece and Cyprus and one of the 24 official languages of the European Union . It

10283-706: The older periods of Greek, loanwords into Greek acquired Greek inflections, thus leaving only a foreign root word. Modern borrowings (from the 20th century on), especially from French and English, are typically not inflected; other modern borrowings are derived from Albanian , South Slavic ( Macedonian / Bulgarian ) and Eastern Romance languages ( Aromanian and Megleno-Romanian ). Greek words have been widely borrowed into other languages, including English. Example words include: mathematics , physics , astronomy , democracy , philosophy , athletics , theatre, rhetoric , baptism , evangelist , etc. Moreover, Greek words and word elements continue to be productive as

10396-414: The oral cavity for the purpose of irrigation (cleaning debris away from the area the dentist is working on), is also referred to as a dental syringe or a dental irrigation nozzle. A 3-way syringe/nozzle has separate internal channels supplying air, water or a mist created by combining the pressurized air with the waterflow. The syringe tip can be separated from the main body and replaced when necessary. In

10509-613: The plasma membrane and a previous preparation to undergo their release. Thus, the second phase of insulin release is governed by the rate at which granules get ready for release. This pool is known as a Reserve Pool (RP). The RP is released slower than the RRP (RRP: 18 granules/min; RP: 6 granules/min). Reduced first-phase insulin release may be the earliest detectable beta cell defect predicting onset of type 2 diabetes . First-phase release and insulin sensitivity are independent predictors of diabetes. The description of first phase release

10622-402: The plasma membrane. PKB also phosphorylates glycogen synthase kinase (GSK), thereby inactivating this enzyme. This means that its substrate, glycogen synthase (GS), cannot be phosphorylated, and remains dephosphorylated, and therefore active. The active enzyme, glycogen synthase (GS), catalyzes the rate limiting step in the synthesis of glycogen from glucose. Similar dephosphorylations affect

10735-416: The plastic plunger and the barrel to create the seal without the need for a separate synthetic rubber piston. Two-part syringes have been traditionally used in European countries to prevent introduction of additional materials such as silicone oil needed for lubricating three-part plungers. Most modern medical syringes are plastic because they are cheap enough to dispose of after being used only once, reducing

10848-497: The positions A7-B7 and A20-B19. There is an additional (intrachain) disulfide bond within the A-chain between cysteine residues at positions A6 and A11. The A-chain exhibits two α-helical regions at A1-A8 and A12-A19 which are antiparallel; while the B chain has a central α -helix (covering residues B9-B19) flanked by the disulfide bond on either sides and two β-sheets (covering B7-B10 and B20-B23). The amino acid sequence of insulin

10961-538: The prey fishes by lowering their blood glucose levels. Insulin is produced exclusively in the beta cells of the pancreatic islets in mammals, and the Brockmann body in some fish. Human insulin is produced from the INS gene , located on chromosome 11. Rodents have two functional insulin genes; one is the homolog of most mammalian genes ( Ins2 ), and the other is a retroposed copy that includes promoter sequence but that

11074-461: The receptor bound to insulin is a main mechanism to end signaling. In addition, the signaling pathway is also terminated by dephosphorylation of the tyrosine residues in the various signaling pathways by tyrosine phosphatases. Serine/Threonine kinases are also known to reduce the activity of insulin. The structure of the insulin– insulin receptor complex has been determined using the techniques of X-ray crystallography . The actions of insulin on

11187-428: The risk of spreading blood-borne diseases . Reuse of needles and syringes has caused spread of diseases, especially HIV and hepatitis , among intravenous drug users. Syringes are also commonly reused by diabetics, as they can go through several in a day with multiple daily insulin injections, which becomes an affordability issue for many. Even though the syringe and needle are only used by a single person, this practice

11300-442: The skin. An oral syringe is a measuring instrument used to accurately measure doses of liquid medication , expressed in millilitres (mL). They do not have threaded tips, because no needle or other device needs to be screwed onto them. The contents are simply squirted or sucked from the syringe directly into the mouth of the person or animal. Oral syringes are available in various sizes, from 1–10 mL and larger. An oral syringe

11413-496: The storage of insulin for long periods. Beta cells in the islets of Langerhans release insulin in two phases. The first-phase release is rapidly triggered in response to increased blood glucose levels, and lasts about 10 minutes. The second phase is a sustained, slow release of newly formed vesicles triggered independently of sugar, peaking in 2 to 3 hours. The two phases of the insulin release suggest that insulin granules are present in diverse stated populations or "pools". During

11526-437: The stressed vowel; the so-called breathing marks ( rough and smooth breathing ), originally used to signal presence or absence of word-initial /h/; and the diaeresis , used to mark the full syllabic value of a vowel that would otherwise be read as part of a diphthong. These marks were introduced during the course of the Hellenistic period. Actual usage of the grave in handwriting saw a rapid decline in favor of uniform usage of

11639-407: The syringe as well. Some culinary uses of syringes are injecting liquids (such as gravy ) into other foods, or for the manufacture of some candies . Syringes may also be used when cooking meat to enhance flavor and texture by injecting juices inside the meat, and in baking to inject filling inside a pastry . It is common for these syringes to be made of stainless steel components, including

11752-406: The syringe is being connected to something not featuring a screw lock mechanism. Similar to this is the catheter tip, which is essentially a slip tip but longer and tapered, making it good for pushing into things where there the plastic taper can form a tight seal. These can also be used for rinsing out wounds or large abscesses in veterinary use. There is also an eccentric tip, where the nozzle at

11865-463: The transcription factors itself. Several regulatory sequences in the promoter region of the human insulin gene bind to transcription factors . In general, the A-boxes bind to Pdx1 factors, E-boxes bind to NeuroD , C-boxes bind to MafA , and cAMP response elements to CREB . There are also silencers that inhibit transcription. Insulin is synthesized as an inactive precursor molecule,

11978-407: The volume of fluid in the syringe, and is nearly always transparent. Glass syringes may be sterilized in an autoclave . Plastic syringes can be constructed as either two-part or three-part designs. A three-part syringe contains a plastic plunger/ piston with a rubber tip to create a seal between the piston and the barrel , where a two-part syringe is manufactured to create a perfect fit between

12091-409: The wound. The most common types have a plastic nozzle which is placed over the affected area, and then the syringe piston is pulled back, creating a vacuum that allegedly sucks out the venom. Attempts to treat snakebites in this way are specifically advised against, as they are ineffective and can cause additional injury. Syringes of this type are sometimes used for extracting human botfly larvae from

12204-574: Was a distinct dialect of Greek itself. Aside from the Macedonian question, current consensus regards Phrygian as the closest relative of Greek, since they share a number of phonological, morphological and lexical isoglosses , with some being exclusive between them. Scholars have proposed a Graeco-Phrygian subgroup out of which Greek and Phrygian originated. Among living languages, some Indo-Europeanists suggest that Greek may be most closely related to Armenian (see Graeco-Armenian ) or

12317-568: Was also used as the official language of government and religion in the Christian Nubian kingdoms , for most of their history. Greek, in its modern form, is the official language of Greece, where it is spoken by almost the entire population. It is also the official language of Cyprus (nominally alongside Turkish ) and the British Overseas Territory of Akrotiri and Dhekelia (alongside English ). Because of

12430-557: Was also used in Ancient Greek. Greek has occasionally been written in the Latin script , especially in areas under Venetian rule or by Greek Catholics . The term Frankolevantinika / Φραγκολεβαντίνικα applies when the Latin script is used to write Greek in the cultural ambit of Catholicism (because Frankos / Φράγκος is an older Greek term for West-European dating to when most of (Roman Catholic Christian) West Europe

12543-456: Was always previously assumed to be food type specific only. Even during digestion, in general, one or two hours following a meal, insulin release from the pancreas is not continuous, but oscillates with a period of 3–6 minutes, changing from generating a blood insulin concentration more than about 800 p mol /l to less than 100 pmol/L (in rats). This is thought to avoid downregulation of insulin receptors in target cells, and to assist

12656-580: Was under the control of the Frankish Empire ). Frankochiotika / Φραγκοχιώτικα (meaning 'Catholic Chiot') alludes to the significant presence of Catholic missionaries based on the island of Chios . Additionally, the term Greeklish is often used when the Greek language is written in a Latin script in online communications. The Latin script is nowadays used by the Greek-speaking communities of Southern Italy . The Yevanic dialect

12769-673: Was written by Romaniote and Constantinopolitan Karaite Jews using the Hebrew Alphabet . In a tradition, that in modern time, has come to be known as Greek Aljamiado , some Greek Muslims from Crete wrote their Cretan Greek in the Arabic alphabet . The same happened among Epirote Muslims in Ioannina . This also happened among Arabic-speaking Byzantine rite Christians in the Levant ( Lebanon , Palestine, and Syria ). This usage

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