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Thebaine ( paramorphine ), also known as codeine methyl enol ether , is an opiate alkaloid , its name coming from the Greek Θῆβαι, Thēbai (Thebes), an ancient city in Upper Egypt . A minor constituent of opium , thebaine is chemically similar to both morphine and codeine , but has stimulatory rather than depressant effects. At high doses, it causes convulsions similar to strychnine poisoning. The synthetic enantiomer (+)-thebaine does show analgesic effects apparently mediated through opioid receptors, unlike the inactive natural enantiomer (−)-thebaine. While thebaine is not used therapeutically, it is the main alkaloid extracted from Papaver bracteatum (Iranian opium / Persian poppy) and can be converted industrially into a variety of compounds, including hydrocodone , hydromorphone , oxycodone , oxymorphone , nalbuphine , naloxone , naltrexone , buprenorphine , butorphanol and etorphine .

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33-483: A poppy is a flowering plant in the subfamily Papaveroideae of the family Papaveraceae . Poppies are herbaceous plants , often grown for their colourful flowers. One species of poppy, Papaver somniferum , is the source of the narcotic drug mixture opium , which contains powerful medicinal alkaloids such as morphine and has been used since ancient times as an analgesic and narcotic medicinal and recreational drug . It also produces edible seeds . Following

66-1818: A molecular phylogeny of plants placed the flowering plants in their evolutionary context: Bryophytes [REDACTED] Lycophytes [REDACTED] Ferns [REDACTED] [REDACTED] [REDACTED] The main groups of living angiosperms are: Amborellales [REDACTED] 1 sp. New Caledonia shrub Nymphaeales [REDACTED] c. 80 spp. water lilies & allies Austrobaileyales [REDACTED] c. 100 spp. woody plants Magnoliids [REDACTED] c. 10,000 spp. 3-part flowers, 1-pore pollen, usu. branch-veined leaves Chloranthales [REDACTED] 77 spp. Woody, apetalous Monocots [REDACTED] c. 70,000 spp. 3-part flowers, 1 cotyledon , 1-pore pollen, usu. parallel-veined leaves   Ceratophyllales [REDACTED] c. 6 spp. aquatic plants Eudicots [REDACTED] c. 175,000 spp. 4- or 5-part flowers, 3-pore pollen, usu. branch-veined leaves Amborellales Melikyan, Bobrov & Zaytzeva 1999 Nymphaeales Salisbury ex von Berchtold & Presl 1820 Austrobaileyales Takhtajan ex Reveal 1992 Chloranthales Mart. 1835 Canellales Cronquist 1957 Piperales von Berchtold & Presl 1820 Magnoliales de Jussieu ex von Berchtold & Presl 1820 Laurales de Jussieu ex von Berchtold & Presl 1820 Acorales Link 1835 Alismatales Brown ex von Berchtold & Presl 1820 Petrosaviales Takhtajan 1997 Dioscoreales Brown 1835 Pandanales Brown ex von Berchtold & Presl 1820 Liliales Perleb 1826 Asparagales Link 1829 Arecales Bromhead 1840 Poales Small 1903 Zingiberales Grisebach 1854 Commelinales de Mirbel ex von Berchtold & Presl 1820 Thebaine Thebaine

99-551: A pollen source . The pollen of the oriental poppy, Papaver orientale , is dark blue, that of the field or corn poppy ( Papaver rhoeas ) is grey to dark green. The opium poppy, Papaver somniferum , grows wild in Southeast Europe and Southeast Asia . It is believed that it originated in the Mediterranean region. Poppies belong to the subfamily Papaveroideae of the family Papaveraceae , which includes

132-442: A woody stem ), grasses and grass-like plants, a vast majority of broad-leaved trees , shrubs and vines , and most aquatic plants . Angiosperms are distinguished from the other major seed plant clade, the gymnosperms , by having flowers , xylem consisting of vessel elements instead of tracheids , endosperm within their seeds, and fruits that completely envelop the seeds. The ancestors of flowering plants diverged from

165-413: A conspicuous whorl in the center of the flower and an ovary of from 2 to many fused carpels. The petals are showy, may be of almost any colour and some have markings. The petals are crumpled in the bud and as blooming finishes, the petals often lie flat before falling away. In the temperate zones, poppies bloom from spring into early summer. Most species secrete latex when injured. Bees use poppies as

198-418: A red poppy on the reverse in 2004, 2008, 2010, and 2015. The 2004 Canadian "poppy" quarter was the world's first coloured circulation coin. Poppies have long been used as a symbol of sleep, peace, and death : Sleep because the opium extracted from them is a sedative , and death because of the common blood-red colour of the red poppy in particular. In Greek and Roman myths, poppies were used as offerings to

231-610: A total of 64 angiosperm orders and 416 families. The diversity of flowering plants is not evenly distributed. Nearly all species belong to the eudicot (75%), monocot (23%), and magnoliid (2%) clades. The remaining five clades contain a little over 250 species in total; i.e. less than 0.1% of flowering plant diversity, divided among nine families. The 25 most species-rich of 443 families, containing over 166,000 species between them in their APG circumscriptions, are: The botanical term "angiosperm", from Greek words angeíon ( ἀγγεῖον 'bottle, vessel') and spérma ( σπέρμα 'seed'),

264-858: Is starting to impact plants and is likely to cause many species to become extinct by 2100. Angiosperms are terrestrial vascular plants; like the gymnosperms, they have roots , stems , leaves , and seeds . They differ from other seed plants in several ways. The largest angiosperms are Eucalyptus gum trees of Australia, and Shorea faguetiana , dipterocarp rainforest trees of Southeast Asia, both of which can reach almost 100 metres (330 ft) in height. The smallest are Wolffia duckweeds which float on freshwater, each plant less than 2 millimetres (0.08 in) across. Considering their method of obtaining energy, some 99% of flowering plants are photosynthetic autotrophs , deriving their energy from sunlight and using it to create molecules such as sugars . The remainder are parasitic , whether on fungi like

297-816: Is controlled under international law, is listed as a Class A drug under the Misuse of Drugs Act 1971 in the United Kingdom, is controlled as an analog of a Schedule II drug per the Analog Act in the United States, and is controlled with its derivatives and salts, as a Schedule I substance of the Controlled Drugs and Substances Act in Canada. The 2013 US Drug Enforcement Administration (DEA) aggregate manufacturing quota for thebaine (ACSCN 9333)

330-469: Is no longer present. Poppy cultivation is strictly regulated worldwide, with the exception of India where opium gum, which also contains the analgesic thebaine , is legally produced. Papaver somniferum was domesticated by the indigenous people of Western and Central Europe between 6000 and 3500 BC. However, it is believed that its origins may come from the Sumerian people , where the first use of opium

363-410: Is often used as cooking oil, salad dressing oil, or in products such as margarine. Poppy oil can also be added to spices for cakes or breads. Poppy products are also used in different paints, varnishes, and some cosmetics. A few species have other uses, principally as sources of drugs and foods. The opium poppy is widely cultivated and its worldwide production is monitored by international agencies. It

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396-546: Is unofficially considered the national flower of the Albanians in Albania , Kosovo and elsewhere. This is due to its red and black colours, the same as the colours of the flag of Albania. Red poppies are also the national flower of Poland . The California poppy, Eschscholzia californica , is the state flower of California. The powerful symbolism of Papaver rhoeas has been borrowed by various advocacy campaigns, such as

429-406: Is used for production of dried latex and opium , the principal precursor of narcotic and analgesic opiates such as morphine , heroin , and codeine . Poppy seeds contain small quantities of both morphine and codeine , which are pain-relieving drugs. Poppy seeds and fixed oils can also be nonnarcotic because when they are harvested about twenty days after the flower has opened, the morphine

462-491: The Alismatales grow in marine environments, spreading with rhizomes that grow through the mud in sheltered coastal waters. Some specialised angiosperms are able to flourish in extremely acid or alkaline habitats. The sundews , many of which live in nutrient-poor acid bogs , are carnivorous plants , able to derive nutrients such as nitrate from the bodies of trapped insects. Other flowers such as Gentiana verna ,

495-658: The White Poppy and Simon Topping 's black poppy. The poppy of wartime remembrance is Papaver rhoeas , the red-flowered corn poppy. This poppy is a common plant of disturbed ground in Europe and is found in many locations, including Flanders , which is the setting of the famous poem " In Flanders Fields " by the Canadian surgeon and soldier John McCrae . In Canada, the United Kingdom, Australia, South Africa and New Zealand, artificial poppies (plastic in Canada, paper in

528-584: The clade Angiospermae ( / ˌ æ n dʒ i ə ˈ s p ər m iː / ). The term 'angiosperm' is derived from the Greek words ἀγγεῖον / angeion ('container, vessel') and σπέρμα / sperma ('seed'), meaning that the seeds are enclosed within a fruit. The group was formerly called Magnoliophyta . Angiosperms are by far the most diverse group of land plants with 64 orders , 416 families , approximately 13,000 known genera and 300,000 known species . They include all forbs (flowering plants without

561-460: The orchids for part or all of their life-cycle, or on other plants , either wholly like the broomrapes, Orobanche , or partially like the witchweeds, Striga . In terms of their environment, flowering plants are cosmopolitan, occupying a wide range of habitats on land, in fresh water and in the sea. On land, they are the dominant plant group in every habitat except for frigid moss-lichen tundra and coniferous forest . The seagrasses in

594-628: The trench warfare in the poppy fields of Flanders , Belgium, during World War I , poppies have become a symbol of remembrance of soldiers who have died during wartime, especially in the UK, Canada, Australia, New Zealand and other Commonwealth realms . Poppies are herbaceous annual , biennial or short-lived perennial plants. Some species are monocarpic , dying after flowering. Poppies can be over 1 metre (3.3 ft) tall with flowers up to 15 centimetres (5.9 in) across. Flowers of species (not cultivars) have 4 or 6 petals, many stamens forming

627-892: The "Big Five" extinction events in Earth's history, only the Cretaceous–Paleogene extinction event had occurred while angiosperms dominated plant life on the planet. Today, the Holocene extinction affects all kingdoms of complex life on Earth, and conservation measures are necessary to protect plants in their habitats in the wild ( in situ ), or failing that, ex situ in seed banks or artificial habitats like botanic gardens . Otherwise, around 40% of plant species may become extinct due to human actions such as habitat destruction , introduction of invasive species , unsustainable logging , land clearing and overharvesting of medicinal or ornamental plants . Further, climate change

660-451: The UK, Australia, South Africa, Malta and New Zealand) are worn to commemorate those who died in war. This form of commemoration is associated with Remembrance Day, which falls on November 11. In Canada, Australia and the UK, poppies are often worn from the beginning of November through to the 11th, or Remembrance Sunday if that falls on a later date. In New Zealand and Australia, soldiers are also commemorated on ANZAC day (April 25), although

693-560: The common ancestor of all living gymnosperms before the end of the Carboniferous , over 300 million years ago. In the Cretaceous , angiosperms diversified explosively , becoming the dominant group of plants across the planet. Agriculture is almost entirely dependent on angiosperms, and a small number of flowering plant families supply nearly all plant-based food and livestock feed. Rice , maize and wheat provide half of

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726-479: The dead. Poppies used as emblems on tombstones symbolize eternal sleep. This symbolism was evoked in L. Frank Baum 's 1900 children's novel The Wonderful Wizard of Oz , in which a magical poppy field threatened to make the protagonists sleep forever. A second interpretation of poppies in Classical mythology is that the bright scarlet colour signifies a promise of resurrection after death. Red-flowered poppy

759-659: The flowering plants as an unranked clade without a formal Latin name (angiosperms). A formal classification was published alongside the 2009 revision in which the flowering plants rank as the subclass Magnoliidae. From 1998, the Angiosperm Phylogeny Group (APG) has reclassified the angiosperms, with updates in the APG II system in 2003, the APG III system in 2009, and the APG IV system in 2016. In 2019,

792-600: The following genera: The flowers of most poppy species are attractive and are widely cultivated as annual or perennial ornamental plants . This has resulted in a number of commercially important cultivars, such as the Shirley poppy, a cultivar of Papaver rhoeas and semi-double or double (flore plena) forms of the opium poppy Papaver somniferum and oriental poppy ( Papaver orientale ). Poppies of several other genera are also cultivated in gardens. Poppy seeds are rich in oil, carbohydrates , calcium and protein . Poppy oil

825-518: The manner of vines or lianas . The number of species of flowering plants is estimated to be in the range of 250,000 to 400,000. This compares to around 12,000 species of moss and 11,000 species of pteridophytes . The APG system seeks to determine the number of families , mostly by molecular phylogenetics . In the 2009 APG III there were 415 families. The 2016 APG IV added five new orders (Boraginales, Dilleniales, Icacinales, Metteniusales and Vahliales), along with some new families, for

858-728: The poppy is still commonly worn around Remembrance Day. Wearing of poppies has been a custom since 1924 in the United States. Moina Michael of Georgia is credited as the founder of the Memorial Poppy in the United States. Artificial poppies (called "Buddy Poppies") are used in the veterans' aid campaign by the Veterans of Foreign Wars , which provides money to the veterans who assemble the poppies and various aid programs to veterans and their families. Flowering plant Basal angiosperms Core angiosperms Flowering plants are plants that bear flowers and fruits , and form

891-494: The primary source of thebaine, with the stem additionally yielding a significant amount. The Canberra Times of 16 November 2022 reported that four batches of Hoyts brand poppy seeds were being recalled due to unusually high levels of thebaine, and that at least twelve people in New South Wales had required medical attention after ingesting them. As of 15 November 2022, Food Standards Australia New Zealand (FSANZ)

924-583: The production of opium. In the 1970s the American war on drugs targeted Turkish production of the plant, leading to a more negative popular opinion of the U.S. The girl's given name "Poppy" is taken from the name of the flower. A poppy flower is depicted on the reverse of the Macedonian 500- denar banknote, issued in 1996 and 2003. The poppy is also part of the coat of arms of North Macedonia . Canada has issued special quarters (25-cent coins) with

957-568: The spring gentian, are adapted to the alkaline conditions found on calcium -rich chalk and limestone , which give rise to often dry topographies such as limestone pavement . As for their growth habit , the flowering plants range from small, soft herbaceous plants , often living as annuals or biennials that set seed and die after one growing season, to large perennial woody trees that may live for many centuries and grow to many metres in height. Some species grow tall without being self-supporting like trees by climbing on other plants in

990-559: The world's staple calorie intake, and all three plants are cereals from the Poaceae family (colloquially known as grasses). Other families provide important industrial plant products such as wood , paper and cotton , and supply numerous ingredients for beverages , sugar production , traditional medicine and modern pharmaceuticals . Flowering plants are also commonly grown for decorative purposes , with certain flowers playing significant cultural roles in many societies. Out of

1023-483: Was coined in the form "Angiospermae" by Paul Hermann in 1690, including only flowering plants whose seeds were enclosed in capsules. The term angiosperm fundamentally changed in meaning in 1827 with Robert Brown , when angiosperm came to mean a seed plant with enclosed ovules. In 1851, with Wilhelm Hofmeister 's work on embryo-sacs, Angiosperm came to have its modern meaning of all the flowering plants including Dicotyledons and Monocotyledons. The APG system treats

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1056-468: Was recognized. Poppies and opium made their way around the world along the silk road . Juglets resembling poppy seed pods have been discovered with trace amounts of opium and the flower appeared in jewelry and on art pieces in Ancient Egypt, dated 1550–1292 BC. The eradication of poppy cultivation came about in the early 1900s through international conferences due to safety concerns associated with

1089-556: Was unchanged from the previous year at 145 metric tons. This alkaloid is biosynthetically related to salutaridine , oripavine , morphine and reticuline . In 2012 there was an amounted 146,000 kilograms of thebaine produced. In 2013, Australia was the main producer of poppy straw rich in thebaine, followed by Spain and then France. By 2017, worldwide thebaine production dropped to 2,008 kg. Together, those three countries accounted for about 99 per cent of global production of such poppy straw. The Papaver bracteatum seed capsules are

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