45-562: Pennyrile may refer to any of the following: the pennyroyal, or European pennyroyal, Mentha pulegium the false or American pennyroyal, Hedeoma pulegioides most commonly, the geographic area of Kentucky named for the plant, and otherwise known as the Pennyroyal Plateau . the Pennyrile Parkway , a Kentucky highway, formerly a toll road, that traverses parts of
90-433: A common source of food allergens. Reactions can range from mild symptoms to severe ones, a condition known as anaphylaxis , which can be life-threatening. The reaction is due to the release of histamine by the body in response to an allergen in the nuts, causing skin and other possible reactions . Many experts suggest that a person with an allergy to peanuts should avoid eating tree nuts, and vice versa. Nuts contain
135-568: A culinary herb and is seldom used as such today. Records from Greek and Roman physicians and scholars contain information pertaining to pennyroyal's medicinal properties, as well as recipes used to prepare it. Pliny the Elder , in his encyclopedia Naturalis Historia ( Natural History ), described the plant as an emmenagogue , and that it also expelled a dead fetus . Galen only listed pennyroyal as an emmenagogue, as did Oribasius . Roman and Greek writers Quintus Serenus Sammonicus and Aspasia
180-496: A cup-shaped structure formed from the flower bracts . The involucre may be scaly, spiny, leafy or tubular, depending on the species of nut. Most nuts come from the pistils with inferior ovaries (see flower ) and all are indehiscent (not opening at maturity). True nuts are produced, for example, by some plant families of the order Fagales . These include beech ( Fagus ), chestnut ( Castanea ), oak ( Quercus ), stone-oak ( Lithocarpus ) and tanoak ( Notholithocarpus ) in
225-464: A green to sometimes red or purplish colour. The leaves, which grow in opposite pairs, are narrowly oval, 2–3 cm long x 1 cm wide, downy, sparsely toothed towards the tip, and taper into a short stalk . All parts of the plant are strongly scented when crushed but it does not have noticeable glands on its surface. The small (6 mm) flowers are densely packed in whorls at the nodes, widely separated, above pairs of leaf-like bracts . The calyx
270-406: A high oil content, they are a significant energy source. Many seeds are edible by humans and used in cooking, eaten raw, sprouted, or roasted as a snack food , ground to make nut butters, or pressed for oil that is used in cooking and cosmetics. Regular nut consumption of more than 5 ounces (140 g) per week may benefit weight control and contribute to lowering body weight in humans. Nuts are
315-523: A mint flavoring in herbal teas and foods. Pennyroyal tea has been used for cold relief, fevers, coughs, indigestion, liver and kidney problems and headaches. The fresh or dried leaves of pennyroyal have also been used when treating influenza, abdominal cramps, to induce sweating, as well as in the treatment of diseases such as smallpox and tuberculosis. To make the tea, the leaves of the plant are boiled in hot water. The lower concentrations of toxic chemicals in these teas are less harmful than pennyroyal oil. It
360-465: A significant degree of pennyroyal's hepatotoxicity . The exact pathway pulegone undergoes to be converted to menthofuran is unknown, but one study strongly suggested it included allylic oxidation of a methyl group (from CYP450), intramolecular cyclization to form a hemiketal, and subsequent dehydration to form the furan. Additionally, pulegone and menthofuran may deplete glutathione levels, leaving hepatocytes vulnerable to free radical damage. There
405-444: A small dose (<10 mL) of pennyroyal oil are nausea, vomiting, abdominal pain and dizziness. Larger volumes may result in multiorgan failure that could lead to death. There are no current toxicokinetics studies performed on humans for the effects of pulegone, but there are some studies performed on other mammals. When pulegone is ingested, it is broken down by the liver and reacts to form multiple toxic metabolites that can wreak havoc in
450-471: A source of essential omega-3 fatty acids . As part of a healthy human diet, long-term consumption of diverse nutrients in nuts may contribute to a lower risk of cardiovascular diseases , reduced levels of blood cholesterol , and lower all-cause mortality . For vegetarians and vegans , nuts provide many of the essential nutrients which may be in short supply in other plant foods . Nuts supply nutrients for humans and wildlife. Because nuts generally have
495-442: A unique case, and grow underground from a legume . Nuts are an energy-dense and nutrient -rich food source. A seed is the mature fertilised ovule of a plant; it consists of three parts, the embryo which will develop into a new plant, stored food for the embryo, and a protective seed coat. Botanically , a nut is a fruit with a woody pericarp developing from a syncarpous gynoecium . Nuts may be contained in an involucre ,
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#1732765228561540-564: A very strong fragrance similar to spearmint . Pennyroyal is a traditional folk remedy , emmenagogue , abortifacient , and culinary herb , but is toxic to the liver and has caused some deaths. European pennyroyal is related to an American species, Hedeoma pulegioides . Though they differ in genera , they share similar chemical properties. An annual to perennial plant with creeping or erect branched stems to about 40 cm in height. The stems are square in cross-section and can vary from hairless on some plants to densely hairy on others, with
585-421: Is a ribbed tube about 3 mm long, with five triangular teeth, the lower two being narrower and slightly longer than the upper three; it is hairy both on the inside and the outside. The corolla has four mauve lobes or "petals" and is hairy only on the outside. The flowers are bisexual and have four long stamens , two (or all four) of which project well beyond the corolla lobes. There is one long style which
630-481: Is considered an axiophyte in many British counties, because low-intensity pasture is a rare habitat, although it has been spreading in recent decades. Its Ellenberg values in Britain are L = 8, F = 7, R = 5, N = 7, and S = 0. Documented use of pennyroyal dates back to ancient Greek , Roman , and Medieval cultures. Its name – although of uncertain etymology – is associated with Latin pulex (flea), alluding to
675-403: Is considered an invasive species, it occupies a similar niche, in seeps, streamsides, vernal pools and swales, marshes, and ditches. There is some speculation that it may displace native species in these areas. Few animals eat pennyroyal. In Britain, the only insect known to feed on it is the bug Heterogaster artemisiae Schilling, which is a seed bug that normally feeds on wild thyme . It
720-740: Is described as "a very lovely land Well croppy, and trimmed and spruced with pennyroyal." Early settlers in colonial Virginia used dried pennyroyal to eradicate pests. Pennyroyal was such a popular herb that the Royal Society published an article on its use against rattlesnakes in the first volume of its Philosophical Transactions in 1665. 17th-century apothecary and physician Nicholas Culpeper mentions pennyroyal in his medical text The English Physitian , published in 1652. In addition to its abortive properties, Culpeper recommends its use for gastrointestinal ailments, such as constipation and hemorrhoids , as well as itching and blemishes to
765-472: Is different from Wikidata All article disambiguation pages All disambiguation pages Mentha pulegium Mentha pulegium , commonly (European) pennyroyal , or pennyrile , also called mosquito plant and pudding grass , is a species of flowering plant in the mint family , Lamiaceae , native to Europe , North Africa , and the Middle East . Crushed pennyroyal leaves emit
810-480: Is forked to produce two stigmas , which also project from the flower. The fruits consist of a cluster of four brown, 1-seeded nutlets , each about 0.7 mm long. The flowering period starts in June and continues into mid-summer, although in northern countries it flowers rather later, sometimes as late as September, when it can fail to set seed. Its chromosome number is 2n = 20. The native range of pennyroyal
855-639: Is no known antidote for pennyroyal toxicity. Case studies involving pennyroyal poisonings have reported the use of gastric lavages and administration of emetics or vomiting inducing agents, or absorbents like activated charcoal . As glutathione depletion has been shown to regulate liver toxification, administration of N-acetylcysteine in similar doses as given for acetaminophen toxicity have been given to patients. A study testing pulegone toxicity found inhibitors of cytochrome P450, such as cobaltous chloride or piperonyl butoxide , blocked toxicity. Such testing has not been expanded to humans, however, as
900-447: Is potentially toxic. Pennyroyal is frequently used as an insecticide and pest repellent. As a pest repellent, it is used to keep fleas away from household animals as well as on humans to ward off gnats and mosquitos. Some flea collars for pets have pennyroyal oil or the herb can be crushed in the lining. Humans have also put crushed pennyroyal stems in their pockets or on their clothing to ward off unwanted insects. However, when using
945-535: Is recommended that people only drink pennyroyal tea periodically, as it is taxing on the body and should not be drunk on a regular basis. Consumption of pennyroyal tea can be fatal to infants and children. In Italy the fresh leaves of this plant, which in Rome and the surrounding area is called menta romana , are used in the capital's cuisine to flavour lamb and tripe . In culinary use it should not be confused with lesser calamint ( Clinopodium nepeta ), which in Rome
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#1732765228561990-436: Is seasonally damp pasture, where standing water over the winter leaves bare ground in the summer, and where livestock preferentially graze other plants. An analogue of this habitat is found on roadsides, where trampling or disturbance of the ground produces similarly bare soil, particularly where there is waterlogging in winter. It is also found along watercourses, in wet woodland and in abandoned fields. In California, where it
1035-403: Is still unknown. Studies using animal models speculate the source of liver toxicity is due to one of the many constituents the plant contains: pulegone, a monoterpene. Pulegone is metabolized by cytochrome P450 (CYP 1A2 and 2E1) and converted to several toxins. Both in vitro and in vivo studies have found the pulegone metabolite menthofuran to be an inhibitor of CYP2A6 , accounting for
1080-488: Is thought to be around the eastern Mediterranean , where it grows in damp meadows, around pools and in stream margins. It is, however, very widely established around the world, including North and South America, throughout Africa, Asia, Australia and New Zealand. In many places it is considered a troublesome weed of agriculture. Towards the northern edge of its range, as in Britain, it is considered to be rare and declining, except where introduced. The habitat of pennyroyal
1125-463: Is toxic to humans and has differing effects dependent on the volume and concentration ingested. The most concentrated and toxic form of the pennyroyal plant is pennyroyal oil. The oil contains 80% to 92% of cyclohexanone pulegone. Pulegone , the molecule in highest concentration in the pennyroyal plant, causes a variety of ailments in those who ingest it and is what causes the plant to have its peppermint flavor. Symptoms that may persist after ingesting
1170-498: Is used to prepare artichokes . The pennyroyal plant has also been used as an emmenagogue and an abortifacient . Chemicals in the pennyroyal plant cause the uterine lining to contract, causing a woman's uterine lining to shed. Women who struggle with regulating their menstrual cycle or suffer from a cystic ovary syndrome may choose to drink pennyroyal tea. Pennyroyal tea is subtle enough to induce menstrual flow with minimal risk of negative health effects. More concentrated versions of
1215-546: Is vital to the activation and binding mechanism of the molecule and causes it to be an effective hepatotoxin . When ingested, pulegone targets the liver and kidney, among other organs. Studies conducted on rats show that one of the main effects is the inhibition of contractile activity in the myometrium and death by kidney failure . The studies also found that long-term exposure to pennyroyal increased incidences of urinary bladder tumors. The exact mechanism of action by which pennyroyal induces menses and abortions in humans
1260-422: The exocarp , or skin, and mesocarp , or flesh, which surround a single pit or stone, the endocarp with a seed (kernel) inside. In a dry drupe, the outer parts dry up and the remaining husk is part of the ovary wall or pericarp , and the hard inner wall surrounding the seed represents the inner part of the pericarp. A small nut may be called a "nutlet" (formerly called a nucule, a term otherwise referring to
1305-412: The oogonium of stoneworts ). In botany , the term "nutlet" can be used to describe a pyrena or pyrene, which is a seed covered by a stony layer, such as the kernel of a drupe . Walnuts and hickories ( Juglandaceae ) have fruits that are difficult to classify. They are considered to be nuts under some definitions but are also referred to as drupaceous nuts. In common use, a "tree nut" is, as
1350-580: The Physician however both agreed that pennyroyal, when served in tepid water, was an effective abortive method. A medical text on gynecology attributed to Cleopatra (though it was actually written by a female Greek physician Metrodora ) recommends the use of pennyroyal with wine to induce abortions. In regard to its contraceptive properties, it was referred to in a joking manner in Aristophanes ' play Peace (421 BCE). The god Hermes provides
1395-450: The body. Some identified metabolites are menthofuran , piperitenone, piperitone , and menthone . The active chemical in pennyroyal is pulegone. Pulegone is a ketone and on the cellular level, ketones can act as enzyme inhibitors . The carbonyl center of the pulegone structure acts as a strong electrophile, causing active sites on enzymes to bind with pulegone instead of the target protein. The exocyclic double bond found in pulegone
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1440-409: The diverse nutrients that are needed for the growth of a new plant. Composition varies, but they tend to have a low water and carbohydrate content, with high levels of fats, protein , dietary minerals , and vitamins . The digestibility of the protein at about 90% is slightly lower than that of meat and fish, but can be improved by chewing thoroughly. The fats are largely unsaturated and nuts are
1485-443: The family Fagaceae , as well as hazel , filbert ( Corylus ) and hornbeam ( Carpinus ) in the family Betulaceae . Also widely known as nuts are dry drupes , which include pecans ( Carya illinoensis ), almonds ( Prunus amygdalus ), macadamia ( Macadamia integrifolia ), candlenut ( Aleurites moluccanus ) and the water caltrop ( Trapa bicornis ). A drupe is an indehiscent fruit that has an outer fleshy part consisting of
1530-461: The male character Trygaios a female companion; when Trygaios asks if there would be a problem if she became pregnant, Hermes responds, "Not if you add a dose of pennyroyal." In a similar manner, in Aristophanes' comedy Lysistrata , after a pregnant female character on stage is told to withhold her body sexually from her husband, a slender female character, in comparison to the pregnant woman,
1575-587: The manner it was used to drive away fleas when smeared on the body. Pennyroyal was commonly incorporated as a cooking herb by the Greeks and Romans . A large number of the recipes in the Roman cookbook of Apicius called for the use of pennyroyal, often along with such herbs as lovage , oregano and coriander . Although it was commonly used for cooking also in the Middle Ages , it gradually fell out of use as
1620-443: The name implies, any nut coming from a tree. This most often comes up regarding food allergies ; a person may be allergic specifically to peanuts (which are not tree nuts but legumes ), whereas others may be allergic to the wider range of nuts that grow on trees. In the 21st century, about a dozen species constitute most of the worldwide production of nuts, shown in the table below for major commercial nuts. Nuts used for food are
1665-438: The pennyroyal mechanism of toxicity is still not entirely understood. Chisholm, Hugh , ed. (1911). "Pennyroyal" . Encyclopædia Britannica (11th ed.). Cambridge University Press. Nut (fruit) In botany , a nut is a fruit from a tree (or shrub) consisting of a hard or tough nutshell protecting a kernel which is usually edible. The shell is indehiscent , meaning it does not open to release
1710-475: The pennyroyal plant as a pest repellent, the use of the concentrated pennyroyal oil should be avoided. Pennyroyal oil can be extremely toxic to both humans and animals, even in small quantities. With the use of pennyroyal around animals and humans comes the risk of it being absorbed through the skin and causing negative health effects. The less concentrated leaves of the plant should be used instead as an insect repellent. Pennyroyal has historically also been used as
1755-522: The percentage of various nutrients in four unroasted seeds. Nuts are under preliminary research to assess whether their consumption is associated with lower risk for some diseases, such as cardiovascular diseases and cancer. A 2014 review indicated that consuming one or more servings of nuts or peanut butter per day was associated with lower risk of ischemic heart disease , overall cardiovascular disease, stroke in women, and all-cause mortality . A 2022 umbrella review confirmed these findings and found
1800-510: The pharmacopeias admitted its use as an "expectorant, diuretic, and emmenagogue" in doses of 10 grains to 1 scruple (0.6–1.3g) of the powdered dried herb, but dismissed the use of the Pennyroyal Water (Aqua Pulegii) as "popularly but erroneously supposed" to be an abortifacient [no mention is made of toxicity]. At least one study has shown pennyroyal oil to have potent acaricidal activity against house dust mites . Pennyroyal
1845-637: The plant, such as the oil, are much more toxic and will likely force a miscarriage if ingested by a pregnant woman. Since the U.S. Congress passed the Dietary Supplement Health and Education Act in October 1994, all manufactured forms of pennyroyal in the United States have carried a warning label against its use by pregnant women, but pennyroyal is not regulated by the U.S. Food and Drug Administration. Rennie's 1833 supplement to
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1890-520: The plateau and the state's adjacent Western Coal Fields. Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title Pennyrile . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Pennyrile&oldid=580948368 " Categories : Disambiguation pages Kentucky culture Hidden categories: Short description
1935-590: The seed. Most seeds come from fruits that naturally free themselves from the shell, but this is not the case in nuts such as hazelnuts , chestnuts , and acorns , which have hard shell walls and originate from a compound ovary . Common usage of the term is less restrictive, which refers to any hard-walled, edible kernel as a nut. This original usage is preserved in a culinary sense, where many dry seeds are called "nuts" and come from indehiscent fruits. Almonds , cashews , pistachios , and Brazil nuts , are examples of "tree nuts" that are not true nuts . Peanuts are
1980-479: The skin, and even toothaches . Pennyroyal is an essential ingredient in the North african dish, which is still eaten to this day, called Batata fliou [ fr ] . Pennyroyal continued to be used up through the 20th and 21st centuries. Its oil is still commercially available today, though little is known about the appropriate dosages for humans. Scientists therefore likely consider it unsafe for use, as it
2025-433: The source of energy and nutrients for the new plant. They contain a relatively large quantity of calories, essential unsaturated and monounsaturated fats including linoleic acid and linolenic acid , vitamins, and essential amino acids. Many nuts are good sources of vitamin E , vitamin B 2 , folate , fiber , and essential minerals, such as magnesium, phosphorus, potassium, copper, and selenium. This table lists
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