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86-484: Roundup is a brand name of herbicide originally produced by Monsanto , which Bayer acquired in 2018. Prior to the late-2010s formulations, it used broad-spectrum glyphosate-based herbicides . As of 2009, sales of Roundup herbicides still represented about 10 percent of Monsanto's revenue despite competition from Chinese producers of other glyphosate-based herbicides. The overall Roundup line of products represented about half of Monsanto's yearly revenue in 2009. The product

172-504: A 2017 risk assessment, the European Chemicals Agency (ECHA) wrote: "There is very limited information on skin irritation in humans. Where skin irritation has been reported, it is unclear whether it is related to glyphosate or co-formulants in glyphosate-containing herbicide formulations." The ECHA concluded that available human data was insufficient to support classification for skin corrosion or irritation. Inhalation

258-405: A case against a claim that Roundup had caused a man's cancer. In a statement they said the outcome was "consistent with the evidence in this case that Roundup does not cause cancer and is not responsible for the plaintiff's illness". At that time, Bayer had previously won 10 of 15 such cases. Most cases claiming injury from Roundup are based on a failure-to-warn theory of liability, meaning Monsanto

344-559: A case in France in 2001 accusing Monsanto of presenting Roundup as "biodegradable" and claiming that it "left the soil clean" after use; glyphosate, Roundup's main ingredient, was classed by the European Union as "dangerous for the environment" and "toxic for aquatic organisms". In January 2007, Monsanto was convicted of false advertising and fined 15,000 euros. The result was confirmed in 2009. On 27 March 2020 Bayer settled claims in

430-443: A chemical company have resulted in controversies. The company once manufactured controversial products such as the insecticide DDT , PCBs , Agent Orange , and recombinant bovine growth hormone . In September 2016, German chemical company Bayer announced its intent to acquire Monsanto for US$ 66 billion in an all-cash deal. After gaining U.S. and EU regulatory approval, the sale was completed on June 7, 2018. The name Monsanto

516-404: A company that produced computer hardware and software designed to enable farmers to increase yield and productivity through more precise planting. Monsanto purchased San Francisco-based Climate Corp for $ 930 million in 2013. Climate Corp makes local weather forecasts for farmers based on data modelling and historical data; if the forecasts were wrong, the farmer was compensated. In May 2013,

602-436: A drug is metabolized by a CYP450 enzyme and drug B blocks the activity of these enzymes, it can lead to pharmacokinetic alterations. A. This alteration results in drug A remaining in the bloodstream for an extended duration, and eventually increase in concentration. In some instances, the inhibition may reduce the therapeutic effect, if instead the metabolites of the drug is responsible for the effect. Compounds that increase

688-437: A formulation. The surfactant POEA is not considered an acute toxicity hazard, and has an oral toxicity similar to vitamin A and less toxic than aspirin . Deliberate ingestion of Roundup ranging from 85 to 200 ml (of 41% solution) has resulted in death within hours of ingestion, although it has also been ingested in quantities as large as 500 ml with only mild or moderate symptoms. Consumption of over 85 ml of concentrated product

774-428: A harmful interaction, including drugs with a narrow therapeutic index , where the difference between the effective dose and the toxic dose is small. The drug digoxin is an example of this type of drug. Risks are also increased when the drug presents a steep dose-response curve , and small changes in the dosage produce large changes in the drug's concentration in the blood plasma. As of 2008, among adults in

860-554: A high bioavailability . For this reason its administration is contraindicated in enteral feeding . Some drugs also alter absorption by acting on the P-glycoprotein of the enterocytes . This appears to be one of the mechanisms by which grapefruit juice increases the bioavailability of various drugs beyond its inhibitory activity on first pass metabolism . Drugs also may affect each other by competing for transport proteins in plasma , such as albumin . In these cases

946-407: A hundred thousand Roundup lawsuits, agreeing to pay $ 8.8 to $ 9.6 billion to settle those claims, and $ 1.5 billion for any future claims. The settlement does not include three cases that have already gone to jury trials and are being appealed. However the settlement was not allowed to cover future cases. In 1996, Monsanto was accused of false and misleading advertising of glyphosate products, prompting

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1032-559: A lawsuit by the New York State attorney general. Monsanto had made claims that its spray-on glyphosate based herbicides, including Roundup, were safer than table salt and "practically non-toxic" to mammals, birds, and fish, "environmentally friendly", and "biodegradable". Citing avoidance of costly litigation, Monsanto settled the case, admitting no wrongdoing, and agreeing to remove the offending advertising claims in New York State. Environmental and consumer rights campaigners brought

1118-532: A long-term agreement to cooperate in the research, development, and marketing of new plant biotechnology products. In 2008, Monsanto purchased Dutch seed company De Ruiter Seeds for €546 million, and sold its POSILAC bovine somatotropin brand and related business to Elanco Animal Health, a division of Eli Lilly & Co , in August for $ 300 million plus "additional contingent consideration". In 2012, Monsanto purchased for $ 210 million Precision Planting Inc. ,

1204-459: A new company, the "new Monsanto", focused on four key agricultural crops—soybeans, maize, wheat and cotton. Monsanto agreed to indemnify Pharmacia against potential liabilities from judgments against Solutia . As a result, the new Monsanto continued to be a party to numerous lawsuits over the prior Monsanto. Pharmacia was bought by Pfizer in 2003. In 2005, Monsanto acquired Emergent Genetics and its Stoneville and NexGen cotton brands. Emergent

1290-405: A number of adjuvants , the identities of which may be proprietary. Surfactants are used in herbicide formulations as wetting agents, to maximize coverage and aid penetration of the herbicide(s) through plant leaves. As agricultural spray adjuvants, surfactants may be pre-mixed into commercial formulations or they may be purchased separately and mixed on-site. Polyethoxylated tallow amine (POEA)

1376-582: A pioneer of optoelectronics in the 1970s. Between 1968 and 1974, the company sponsored the PGA Tour event in Pensacola, Florida, which was renamed the Monsanto Open . In 1974, Harvard University and Monsanto signed a 10-year research grant to support the cancer research of Judah Folkman , which became the largest such arrangement ever made; medical inventions arising from that research were

1462-415: A post-emergence herbicide against most broadleaf and cereal weeds. The health impacts of the product as well as its effects on the environment have been at the center of substantial legal and scientific controversies. In June 2020, Bayer agreed to pay $ 9.6 billion to settle tens of thousands of claims, mostly alleging that glyphosate-based Roundup had caused cancer. Glyphosate-based formulations may contain

1548-758: A proposed class action alleging that it falsely advertised that the active ingredient in Roundup Weed & Grass Killer only affects plants with a $ 39.5 million deal that included changing the labels on its products. In June 2023, Bayer reached a $ 6.9 million settlement agreement with the New York attorney general, settling false advertising allegations concerning the safety of Roundup. Some tests originally conducted on glyphosate by contractors were later found to have been fraudulent, along with tests conducted on other pesticides. Concerns were raised about toxicology tests conducted by Industrial Bio-Test Laboratories in

1634-570: A release of catecholamines , triggering symptoms that hint the organism to take action, like consuming sugary foods. If a patient is on insulin , which reduces blood sugar, and also beta-blockers , the body is less able to cope with an insulin overdose. Pharmacokinetics is the field of research studying the chemical and biochemical factors that directly affect dosage and the half-life of drugs in an organism, including absorption, transport, distribution, metabolism and excretion. Compounds may affect any of those process, ultimately interfering with

1720-541: A state list of cancer-causing items. In the ten months following Bayer's June 2018 acquisition of Monsanto, its stock lost 46% of its value because of investor apprehension concerning the 11,200 lawsuits filed against its subsidiary. As of 2023, around 165,000 claims have been made against Bayer, mostly alleging that Roundup had caused cancer. Bayer has settled tens of thousands of those claims and has agreed to pay billions in damages, but, as of 2023, more than 50,000 similar claims were still pending. In December 2023, Bayer won

1806-556: A way to selectively synthesize enantiomers via asymmetric hydrogenation . This was the first method for the catalytic production of pure chiral compounds. Knowles' team designed the "first industrial process to chirally synthesize an important compound"— L‑dopa , which is used to treat Parkinson's disease . In 2001, Knowles and Ryōji Noyori won the Nobel Prize in Chemistry . In the mid-1960s, chemists at Monsanto developed

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1892-463: A worldwide protest against Monsanto corporation, called March Against Monsanto , was held in over 400 cities. A second protest took place in May 2014. Monsanto tried to acquire Swiss agro-biotechnology rival Syngenta for US$ 46.5 billion in 2015, but failed. In that year Monsanto was the world's biggest supplier of seeds, controlling 26% of the global seed market (Du Pont was second with 21%). Monsanto

1978-480: Is Roundup , a glyphosate -based herbicide , developed in the 1970s. Later, the company became a major producer of genetically engineered crops. In 2018, the company ranked 199th on the Fortune 500 of the largest United States corporations by revenue. Monsanto was one of four groups to introduce genes into plants in 1983, and was among the first to conduct field trials of genetically modified crops in 1987. It

2064-409: Is a minor route of exposure, but spray mist may cause oral or nasal discomfort, an unpleasant taste in the mouth, or tingling and irritation in the throat. Eye exposure may lead to mild conjunctivitis. Superficial corneal injury is possible if irrigation is delayed or inadequate. Glyphosate formulations with POEA, such as Roundup, are not approved for aquatic use due to aquatic organism toxicity. Due to

2150-511: Is a surfactant used in the original Roundup formulation and was commonly used in 2015. Different versions of Roundup have included different percentages of POEA. A 1997 US government report said that Roundup is 15% POEA while Roundup Pro is 14.5%. Since POEA is more toxic to fish and amphibians than glyphosate alone, POEA is not allowed in aquatic formulations. Non-glyphosate formulations of Roundup are typically used for lawns that glyphosate would otherwise kill. Both type of products being sold under

2236-415: Is due to surfactants in the formulations blocking the tracheal system of the bees. There is limited evidence that human cancer risk might increase as a result of occupational exposure to large amounts of glyphosate, such as agricultural work, but no good evidence of such a risk from home use, such as in domestic gardening. The consensus among national pesticide regulatory agencies and scientific organizations

2322-686: Is liable for a plaintiff's injury because it failed to warn the plaintiff that Roundup can cause cancer. The United States Court of Appeals for the Ninth Circuit in 2021, and the United States Court of Appeals for the Eleventh Circuit in early 2024, held that such state-law failure to warn claims were not preempted by the Federal Insecticide, Fungicide, and Rodenticide Act ("FIFRA"). In August 2024, however,

2408-557: Is likely to cause serious symptoms in adults, including burns due to corrosive effects as well as kidney and liver damage. More severe cases lead to "respiratory distress, impaired consciousness, pulmonary edema , infiltration on chest X-ray, shock, arrhythmias, kidney failure requiring haemodialysis, metabolic acidosis, and hyperkalaemia" and death is often preceded by bradycardia and ventricular arrhythmias . Skin exposure can cause irritation, and photocontact dermatitis has been occasionally reported. Severe skin burns are very rare. In

2494-432: Is limited to drift or temporary water pockets. While laboratory studies can show effects of glyphosate formulations on aquatic organisms, similar observations rarely occur in the field when instructions on the herbicide label are followed. Studies in a variety of amphibians have shown the toxicity of products containing POEA to amphibian larvae. These effects include interference with gill morphology and mortality from either

2580-597: Is marketed to consumers by Scotts Miracle-Gro Company . In the late-2010s other non-glyphosate containing herbicides were also sold under the Roundup brand. Monsanto developed and patented the glyphosate molecule in the 1970s, and marketed it as Roundup from 1973. It retained exclusive rights to glyphosate in the US until its US patent expired in September 2000; in other countries the patent expired earlier. The Roundup trademark

2666-464: Is opposite to that of the main drug. These may be c ompetitive antagonists , if they compete with the main drug to bind with the receptor. or u ncompetitive antagonists, when the antagonist binds to the receptor irreversibly. The drugs can be considered heterodynamic competitors, if they act on distinct receptor with similar downstream pathways . The interaction my also occur via signal transduction mechanisms. For example, low blood glucose leads to

Roundup (herbicide) - Misplaced Pages Continue

2752-654: Is registered with the US Patent and Trademark Office and still extant. However, glyphosate is no longer under patent, so similar products use it as an active ingredient. The main active ingredient of Roundup is the isopropylamine salt of glyphosate. Another ingredient of Roundup is the surfactant POEA ( polyethoxylated tallow amine ). Monsanto also produced seeds which grow into plants genetically engineered to be tolerant to glyphosate, which are known as Roundup Ready crops. The genes contained in these seeds are patented. Such crops allow farmers to use glyphosate as

2838-635: Is that labeled uses of glyphosate have demonstrated no evidence of human carcinogenicity . Organizations such as the Joint FAO / WHO Meeting on Pesticide Residues and the European Commission , Canadian Pest Management Regulatory Agency , and the German Federal Institute for Risk Assessment have concluded that there is no evidence that glyphosate poses a carcinogenic or genotoxic risk to humans. The final assessment of

2924-411: Is the case for oral anticoagulants and avocado . The formation of non-absorbable complexes may occur also via chelation , when cations can make certain drugs harder to absorb, for example between tetracycline or the fluoroquinolones and dairy products, due to the presence of calcium ions . . Other drugs bind to proteins. Some drugs such as sucralfate bind to proteins, especially if they have

3010-562: The Australian Pesticides and Veterinary Medicines Authority in 2017 was that "glyphosate does not pose a carcinogenic risk to humans". The EPA has evaluated the carcinogenic potential of glyphosate multiple times since 1986. In 1986, glyphosate was initially classified as Group C: "Possible Human Carcinogen", but later recommended as Group D: "Not Classifiable as to Human Carcinogenicity" due to lack of statistical significance in previously examined rat tumor studies. In 1991, it

3096-625: The Dayton Project , and later Mound Laboratories , and assisted in the development of the first nuclear weapons . In 1946, Monsanto developed and marketed "All" laundry detergent, which it sold to Lever Brothers in 1957. In 1947, its styrene factory was destroyed in the Texas City Disaster . In 1949, Monsanto acquired American Viscose Corporation from Courtaulds . In 1954, Monsanto partnered with German chemical giant Bayer to form Mobay and market polyurethanes in

3182-564: The IARC , based in Lyon. Monsanto first developed Roundup in the 1970s. End-users initially used it in a similar way to paraquat and diquat – as a non-selective herbicide. Application of glyphosate-based herbicides to row crops resulted in problems with crop damage and kept them from being widely used for this purpose. In the United States, use of Roundup experienced rapid growth following

3268-885: The Monsanto process for making acetic acid , which until 2000 was the most widely used production method. In 1964, Monsanto chemists invented AstroTurf (initially ChemGrass). In the 1960s and 1970s, Monsanto was a producer of Agent Orange for United States Armed Forces operations in Vietnam , and settled out of court in a lawsuit brought by veterans in 1984. In 1968, it became the first company to start mass production of (visible) light-emitting diodes (LEDs), using gallium arsenide phosphide . From 1968 to 1970, sales doubled every few months. Their products (discrete LEDs and seven-segment numeric displays) became industry standards. The primary markets then were electronic calculators , digital watches and digital clocks. Monsanto became

3354-454: The artificial sweetener saccharin , caffeine and vanillin . Monsanto expanded to Europe in 1919 in a partnership with Graesser's Chemical Works at Cefn Mawr , Wales. The venture produced vanillin, aspirin and its raw ingredient salicylic acid , and later rubber processing chemicals. In the 1920s, Monsanto expanded into basic industrial chemicals such as sulfuric acid and PCBs . Queeny's son Edgar Monsanto Queeny took over

3440-565: The maize seed business when it purchased 40% of Dekalb in 1996; it purchased the remainder of the corporation in 1998. In 1997, the company first published an annual report citing Monsanto's Law, a biotechnological take on Moore's Law , indicating its future directions and exponential growth in the use of biotechnology. In the same year, Californian GMO company Calgene was acquired. In 1998, Monsanto purchased Cargill 's international seed business, which gave it access to sales and distribution facilities in 51 countries. In 2005, it finalized

3526-442: The precipitation of thiopentone. Pharmacodynamic interactions are the drug–drug interactions that occur at a biochemical level and depend mainly on the biological processes of organisms. These interactions occur due to action on the same targets; for example, the same receptor or signaling pathway . Pharmacodynamic interactions can occur on protein receptors . Two drugs can be considered to be homodynamic , if they act on

Roundup (herbicide) - Misplaced Pages Continue

3612-629: The "new" Pharmacia; Monsanto's medical research division, which included products such as Celebrex. PL Laboratories LKB-produkter AB (Acq 1968) Kabi Vitrum (Acq 1990) Farmitalia (Acq 1993) Upjohn (Merged 1995) Monsanto (Est 1901) Swann Chemical Company (Acq 1935) Thomas & Hochwalt Laboratories (Acq 1936) American Viscose (Acq 1949) G. D. Searle & Company (Acq 1985) Agracetus (Acq 1996) DeKalb Genetics Corporation (Acq 1998) Cargill (Seed div, Acq 1998) In 2000, Pharmacia spun off its agro-biotech subsidiary into

3698-513: The 1970s and Craven Laboratories was found to have fraudulently analysed samples for residues of glyphosate in 1991. Monsanto has stated that the studies have since been repeated. In January 2019, Roundup Pro 360 was banned in France following a Lyon court ruling that regulator ANSES had not given due weight to safety concerns when they approved the product in March 2017. The ban went into effect immediately. The court's decision cited research by

3784-518: The Roundup brand name can be a source of confusion for consumers. Active ingredients for non-glyphosate formulations of Roundup can include MCPA , quinclorac , dicamba , and sulfentrazone , penoxsulam , and 2,4-D The lethal dose of different glyphosate-based formulations varies, especially with respect to the surfactants used. Formulations intended for terrestrial use that include the surfactant polyethoxylated tallow amine (POEA) can be more toxic than other formulations for aquatic species. Due to

3870-660: The Supreme Court can resolve the conflict among the Courts of Appeals. As of October 30, 2019, there were over 42,000 plaintiffs who said that glyphosate herbicides caused their cancer. After the IARC classified glyphosate as "probably carcinogenic to humans" in March 2015, many state and federal lawsuits were filed in the United States. Early on, over 300 of them were consolidated into a multidistrict litigation called In re: RoundUp Products Liability . On August 10, 2018, Dewayne Johnson , who has non-Hodgkin's lymphoma ,

3956-407: The U.S. Food and Drug Administration (FDA). Celebrex became a blockbuster drug and was often mentioned as a key reason for Pfizer 's acquisition of Monsanto's pharmaceutical business in 2002. In 1994, Monsanto introduced a recombinant version of bovine somatotropin , brand-named Posilac. Monsanto later sold this business to Eli Lilly and Company . In 1996, Monsanto purchased Agracetus ,

4042-656: The United States Court of Appeals for the Third Circuit held that FIFRA does preempt state-law failure to warn claims involving Roundup, expressly recognizing that its holding conflicts with that of the Ninth and Eleventh Circuits. This conflict among the Third, Ninth and Eleventh Circuit creates a heightened potential that the United States Supreme Court will review the Third Circuit's decision so that

4128-423: The United States. Monsanto began manufacturing DDT in 1944, along with some 15 other companies. This insecticide was used to kill malaria -transmitting mosquitoes, but it was banned in the United States in 1972 due to its harmful environmental impacts. In 1977, Monsanto stopped producing PCBs; Congress banned PCB production two years later. In the mid‑1960s, William Standish Knowles and his team invented

4214-442: The absorption of other drugs such as zalcitabine , tipranavir and amprenavir . The opposite is more common, with, for example, the antacid cimetidine stimulating the absorption of didanosine . Some resources describe that a gap of two to four hours between taking the two drugs is needed to avoid the interaction. Factors such as food with high-fat content may also alter the solubility of drugs and impact its absorption. This

4300-471: The appearance of interactions include factors such as old age . This is where human physiology changing with age may affect the interaction of drugs. For example, liver metabolism, kidney function, nerve transmission, or the functioning of bone marrow all decrease with age. In addition, in old age, there is a sensory decrease that increases the chances of errors being made in the administration of drugs. The elderly are also more vulnerable to polypharmacy , and

4386-399: The biotechnology company that had generated the first transgenic cotton, soybeans, peanuts and other crops, and from which Monsanto had been licensing technology since 1991. In 1997, Monsanto divested Solutia , a company created to carry off the responsibility for Monsanto's PCB business and associated liabilities, along with some related organic chemical production. Monsanto first entered

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4472-460: The business of producing PCBs . In 1936, Monsanto acquired Thomas & Hochwalt Laboratories in Dayton, Ohio , to acquire the expertise of Charles Allen Thomas and Carroll A. Hochwalt. The acquisition became Monsanto's Central Research Department. Thomas spent the rest of his career at Monsanto, serving as President (1951–1960) and Board Chair (1960–1965). He retired in 1970. In 1943, Thomas

4558-638: The chemical, but as of 2012 glyphosate treated approximately 5 million acres in California for crops like almond , peach , cantaloupe , onion , cherry , sweet corn , and citrus , although the product is only applied directly to certain varieties of sweet corn. Monsanto The Monsanto Company ( / m ɒ n ˈ s æ n t oʊ / ) was an American agrochemical and agricultural biotechnology corporation founded in 1901 and headquartered in Creve Coeur, Missouri . Monsanto's best-known product

4644-417: The commercial introduction of a glyphosate-resistant soybean in 1996. "Roundup Ready" became Monsanto's trademark for its patented line of crop seeds that are resistant to Roundup. Between 1990 and 1996 sales of Roundup increased around 20% per year. As of 2015 the product was used in over 160 countries. Roundup is used most heavily on corn, soy, and cotton crops that have been genetically modified to withstand

4730-652: The company in 1928. In 1926 the company founded and incorporated a town called Monsanto in Illinois (now known as Sauget ). It was formed to provide minimal regulation and low taxes for Monsanto plants at a time when local jurisdictions had most of the responsibility for environmental rules. It was renamed in honor of Leo Sauget, its first village president. In 1935, Monsanto bought the Swann Chemical Company in Anniston, Alabama , and thereby entered

4816-541: The drug that arrives first binds with the plasma protein, leaving the other drug dissolved in the plasma, modifying its expected concentration. The organism has mechanisms to counteract these situations (by, for example, increasing plasma clearance ), and thus they are not usually clinically relevant. They may become relevant if other problems are present, such as issues with drug excretion. Many drug interactions are due to alterations in drug metabolism . Further, human drug-metabolizing enzymes are typically activated through

4902-454: The efficiency of the enzymes, on the other hand, may have the opposite effect and increase the rate of metabolism. An example of this is shown in the following table for the CYP1A2 enzyme, showing the substrates (drugs metabolized by this enzyme) and some inductors and inhibitors of its activity: Some foods also act as inductors or inhibitors of enzymatic activity. The following table shows

4988-406: The engagement of nuclear receptors . One notable system involved in metabolic drug interactions is the enzyme system comprising the cytochrome P450 oxidases . Cytochrome P450 is a very large family of haemoproteins (hemoproteins) that are characterized by their enzymatic activity and their role in the metabolism of a large number of drugs. Of the various families that are present in humans,

5074-414: The evaluation of the available evidence". In 2017, California environmental regulators listed glyphosate as “known to the state to cause cancer.” The state's Office of Environmental Health Hazard Assessment made the decision based in part on the report from the IARC . State Proposition 65 requires the state office to add substances the international agency deems carcinogenic in humans or laboratory animals to

5160-453: The first for which Harvard allowed its faculty to submit patent application . Monsanto scientists were among the first to genetically modify a plant cell, publishing their results in 1983. Five years later the company conducted the first field tests of genetically modified crops . Increasing involvement in agricultural biotechnology dates from the installment of Richard Mahoney as Monsanto's CEO in 1983. This involvement increased under

5246-589: The flux of drugs in the human body , increasing or reducing drug availability. Drugs that change intestinal motility may impact the level of other drugs taken. For example, prokinetic agents increase the intestinal motility , which may cause drugs to go through the digestive system too fast, reducing absorption. The pharmacological modification of pH can affect other compounds. Drugs can be present in ionized or non-ionized forms depending on pKa , and neutral compounds are usually better absorbed by membranes. Medication like antacids can increase pH and inhibit

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5332-439: The leadership of Robert Shapiro , appointed CEO in 1995, leading ultimately to the disposition of product lines unrelated to agriculture. In 1985, Monsanto acquired G.D. Searle & Company , a life sciences company that focused on pharmaceuticals, agriculture and animal health. In 1993, its Searle division filed a patent application for Celebrex , which in 1998 became the first selective COX‑2 inhibitor to be approved by

5418-747: The longer term. In June 2007, Monsanto purchased Delta and Pine Land Company , a major cotton seed breeder, for $ 1.5 billion. As a condition for approval from the Department of Justice , Monsanto was obligated to divest its Stoneville cotton business, which it sold to Bayer , and to divest its NexGen cotton business, which it sold to Americot . Monsanto also exited the pig-breeding business by selling Monsanto Choice Genetics to Newsham Genetics LC in November, divesting itself of "any and all swine-related patents, patent applications, and all other intellectual property". In 2007, Monsanto and BASF announced

5504-502: The loss of osmotic stability or asphyxiation. At sub-lethal concentrations, exposure to POEA or glyphosate/POEA formulations have been associated with delayed development, accelerated development, reduced size at metamorphosis , developmental malformations of the tail, mouth, eye and head, histological indications of intersex and symptoms of oxidative stress. Glyphosate-based formulations can cause oxidative stress in bullfrog tadpoles. The use of glyphosate-based pesticides are not considered

5590-663: The major cause of amphibian decline, the bulk of which occurred prior to widespread use of glyphosate or in pristine tropical areas with minimal glyphosate exposure. A 2000 review of the toxicological data on Roundup concluded that "for terrestrial uses of Roundup minimal acute and chronic risk was predicted for potentially exposed nontarget organisms". It also concluded that there were some risks to aquatic organisms exposed to Roundup in shallow water. Roundup Ready‐To‐Use, Roundup No Glyphosate, and Roundup ProActive have all been found to cause significant mortality in bumblebees when sprayed directly on them. It has been hypothesized that this

5676-403: The more drugs a patient takes, the higher is the chance of an interaction. Genetic factors may also affect the enzymes and receptors, thus altering the possibilities of interactions. Patients with hepatic or renal diseases already may have difficulties metabolizing and excreting drugs, which may exacerbate the effect of interactions. Some drugs present an intrinsic increased risk for

5762-1551: The most common: Drugs tightly bound to proteins (i.e. not in the free fraction ) are not available for renal excretion . Filtration depends on a number of factors including the pH of the urine. Drug interactions may affect those points. Herb-drug interactions are drug interactions that occur between herbal medicines and conventional drugs. These types of interactions may be more common than drug-drug interactions because herbal medicines often contain multiple pharmacologically active ingredients, while conventional drugs typically contain only one. Some such interactions are clinically significant , although most herbal remedies are not associated with drug interactions causing serious consequences. Most catalogued herb-drug interactions are moderate in severity. The most commonly implicated conventional drugs in herb-drug interactions are warfarin , insulin , aspirin , digoxin , and ticlopidine , due to their narrow therapeutic indices . The most commonly implicated herbs involved in such interactions are those containing St. John’s Wort , magnesium, calcium, iron, or ginkgo . Examples of herb-drug interactions include, but are not limited to: The mechanisms underlying most herb-drug interactions are not fully understood. Interactions between herbal medicines and anticancer drugs typically involve enzymes that metabolize cytochrome P450 . For example, St. John's Wort has been shown to induce CYP3A4 and P-glycoprotein in vitro and in vivo. The factors or conditions that predispose

5848-477: The most interesting in this respect are the 1, 2 and 3, and the most important enzymes are CYP1A2 , CYP2C9 , CYP2C19 , CYP2D6 , CYP2E1 and CYP3A4 . The majority of the enzymes are also involved in the metabolism of endogenous substances, such as steroids or sex hormones , which is also important should there be interference with these substances. The function of the enzymes can either be stimulated ( enzyme induction ) or inhibited ( enzyme inhibition ). If

5934-568: The possible carcinogenicity of Roundup. On December 19, 2019, it was announced that Timothy Litzenburg, the lawyer for the RoundUp Virginia plaintiffs had been charged with extortion after offering to stop searching for more plaintiffs if he was paid a $ 200 million consulting fee by a manufacturer of glyphosate. Litzenburg and his partner Daniel Kincheloe pleaded guilty to the charges and they were sentenced to two and one years in prison respectively. In June 2020, Bayer agreed to settle over

6020-421: The presence of POEA, glyphosate formulations only allowed for terrestrial use are more toxic for amphibians and fish than glyphosate alone. Terrestrial glyphosate formulations that include the surfactants POEA and MON 0818 (75% POEA) may have negative impacts on various aquatic organisms like protozoa , mussels , crustaceans , frogs and fish . Aquatic organism exposure risk to terrestrial formulations with POEA

6106-424: The product label is properly followed. The acute oral toxicity for mammals is low, but death has been reported after deliberate overdose of concentrated Roundup. The surfactants in glyphosate formulations can increase the relative acute toxicity of the formulation. Surfactants generally do not, however, cause synergistic effects (as opposed to additive effects) that increase the acute toxicity of glyphosate within

6192-419: The public court cases. In March 2019, a man was awarded $ 80 million (later cut to $ 26 million on appeal) in a lawsuit claiming Roundup was a substantial factor in his cancer. U.S. District Judge Vince Chhabria stated that a punitive award was appropriate because the evidence "easily supported a conclusion that Monsanto was more concerned with tamping down safety inquiries and manipulating public opinion than it

6278-406: The purchase of Seminis Inc , a leading global vegetable and fruit seed company, for $ 1.4 billion. This made it the world's largest conventional seed company. In 1999, Monsanto sold off NutraSweet Co. In December of the same year, Monsanto agreed to merge with Pharmacia & Upjohn , in a deal valuing the transaction at $ 27 billion. The agricultural division became a wholly owned subsidiary of

6364-399: The question of whether Monsanto knowingly failed to warn consumers that RoundUp could be harmful, but not whether RoundUp causes cancer. Court documents from the case alleged the company's efforts to influence scientific research via ghostwriting . In January 2019, Costco decided to stop carrying Roundup or other glyphosate-based herbicides. The decision was reportedly influenced in part by

6450-709: The receptor, which can lead to loss of consciousness. When two drugs affect each other, it is a drug–drug interaction (DDI) . The risk of a DDI increases with the number of drugs used. A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. Drug interactions can be of three kinds: It may be difficult to distinguish between synergistic or additive interactions, as individual effects of drugs may vary. Direct interactions between drugs are also possible and may occur when two drugs are mixed before intravenous injection . For example, mixing thiopentone and suxamethonium can lead to

6536-409: The same receptor. Homodynamic effects include drugs that act as (1) pure agonists , if they bind to the main locus of the receptor , causing a similar effect to that of the main drug, (2) partial agonists if, on binding to a secondary site, they have the same effect as the main drug, but with a lower intensity and (3) antagonists , if they bind directly to the receptor's main locus but their effect

6622-422: The variety in available formulations, including five different glyphosate salts and different combinations of inert ingredients, it is difficult to determine how much surfactants contribute to the overall toxicity of each formulation. Independent scientific reviews and regulatory agencies have repeatedly concluded that glyphosate-based herbicides do not lead to a significant risk for human or environmental health when

6708-497: Was awarded $ 289 million in damages (later cut to $ 78 million on appeal then reduced to $ 21 million after another appeal) after a jury in San Francisco found that Monsanto had failed to adequately warn consumers of cancer risks posed by the herbicide. Johnson had routinely used two different glyphosate formulations in his work as a groundskeeper, RoundUp and another Monsanto product called Ranger Pro. The jury's verdict addressed

6794-854: Was called to a meeting in Washington, D.C., with Leslie Groves , commander of the Manhattan Project , and James Conant , president of Harvard University and chairman of the National Defense Research Committee (NDRC). They urged Thomas to become co-director of the Manhattan Project at Los Alamos with Robert Oppenheimer , but Thomas was reluctant to leave Dayton and Monsanto. He joined the NDRC, and Monsanto's Central Research Department began to conduct related research. To that end, Monsanto operated

6880-594: Was classified as Group E: "Evidence of Non-Carcinogenicity for Humans", and in 2015 and 2017, "Not Likely to be Carcinogenic to Humans". One international scientific organization, the International Agency for Research on Cancer ( IARC ), classified glyphosate in Group 2A , "probably carcinogenic to humans" in 2015. The variation in classification between this agency and others has been attributed to "use of different data sets" and "methodological differences in

6966-507: Was founded in St. Louis, Missouri, as a chemical company . The founder was John Francis Queeny , who, at age 42, was a 30‑year veteran of the nascent pharmaceutical industry. He funded the firm with his own money and capital from a soft drink distributor. He used for the company name the maiden name of his wife, Olga Méndez Monsanto, who was a scioness of the Monsanto family . The company's first products were commodity food additives, such as

7052-514: Was no longer used, but Monsanto's previous product brand names were maintained. In June 2020, Bayer agreed to pay numerous settlements in lawsuits involving ex-Monsanto products Roundup , PCBs and Dicamba . Owing to the massive financial and reputational blows caused by ongoing litigation concerning Monsanto's herbicide Roundup, the Bayer-Monsanto merger is considered one of the worst corporate mergers in history. In 1901, Monsanto

7138-587: Was one of the top-ten U.S. chemical companies until it divested most of its chemical businesses between 1997 and 2002, through a process of mergers and spin-offs that focused the company on biotechnology . Monsanto was one of the first companies to apply the biotechnology industry business model to agriculture, using techniques developed by biotech drug companies. In this business model, companies recoup R&D expenses by exploiting biological patents . Monsanto's roles in agricultural changes, biotechnology products, lobbying of government agencies, and roots as

7224-418: Was the only manufacturer of white phosphorus for military use in the US. Monsanto (Spun off from Pharmacia & Upjohn 2000) Drug interaction#Synergy and antagonism Interactions may occur by simultaneous targeting of receptors , directly or indirectly. For example, both Zolpidem and alcohol affect GABA A receptors , and their simultaneous consumption results in the overstimulation of

7310-544: Was the third-largest U.S. cotton seed company, with about 12% of the U.S. market. Monsanto's goal was to obtain "a strategic cotton germplasm and traits platform". Also in 2005, Monsanto purchased Seminis , the California-based world leader in vegetable seed production, for $ 1.4 billion. Seminis developed new vegetable varieties using advanced cross-pollination methods. Monsanto indicated that Seminis would continue with non-GM development, while not ruling out GM in

7396-514: Was with ensuring its product is safe." Chhabria stated that there was evidence on both sides as to whether glyphosate causes cancer, and that the behavior of Monsanto showed "a lack of concern about the risk that its product might be carcinogenic." On May 13, 2019, a jury in California ordered Bayer to pay a couple $ 2 billion in damages (later cut to $ 87 million on appeal) after finding that the company had failed to adequately inform consumers of

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