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113-547: Historically the indigenous Sauk Native Americans used Rock Island as their summer camp site. Encroaching European Americans coming into the area disputed the claim of tribal ownership, and competition between the peoples led to the Black Hawk War of 1832. It was named for Black Hawk , the primary leader of the Sauk . In 1816 the federal government authorized the army to build Fort Armstrong here, to protect shipping on

226-410: A marker gene . This gene, called GFP , or green fluorescent protein, would cause live samples of the virus to glow green under fluorescent light. The insertion of this gene, which would not influence the virulence of the virus, would be the only allowed modification of the genome. The committee stated the proposed modification would aid in research of treatments by making it easier to assess whether

339-443: A clinical case was observed, smallpox was confirmed using laboratory tests. Microscopically , poxviruses produce characteristic cytoplasmic inclusion bodies , the most important of which are known as Guarnieri bodies , and are the sites of viral replication . Guarnieri bodies are readily identified in skin biopsies stained with hematoxylin and eosin, and appear as pink blobs. They are found in virtually all poxvirus infections but

452-415: A discrete rash, in which the pustules stood out on the skin separately. The distribution of the rash was most dense on the face, denser on the extremities than on the trunk, and denser on the distal parts of the extremities than on the proximal. The palms of the hands and soles of the feet were involved in most cases. Sometimes, the blisters merged into sheets, forming a confluent rash, which began to detach

565-518: A doctor in Berkeley, Gloucestershire , rural England, discovered that immunity to smallpox could be produced by inoculating a person with material from a cowpox lesion. Cowpox is a poxvirus in the same family as variola. Jenner called the material used for inoculation vaccine from the root word vacca , which is Latin for cow. The procedure was much safer than variolation and did not involve a risk of smallpox transmission. Vaccination to prevent smallpox

678-670: A dramatic change before women’s suffrage was approved. Women were absolutely critical to the success of the US buildup in World War I, and played an integral role in production at Rock Island Arsenal. The Rock Island Arsenal Museum was established on July 4, 1905. It is the second-oldest US Army Museum in the US after the West Point Museum . The museum has been closed twice, during World War I and World War II , to provide more space for manufacturing facilities. Exhibits interpret

791-455: A fatality rate of around 30%, while variola minor’s mortality rate was about 1%. Throughout the 18th century, variola major was responsible for around 400,000 deaths annually in Europe alone. Survivors of the disease often faced lifelong consequences, such as blindness and severe scarring, which were nearly universal among those who recovered. In the first half of the 20th century, variola major

904-476: A guard post to control traffic on the Mississippi and maintain watch over the local Native Americans. Black Hawk wrote in his memoir: "When we arrived we found that the troops had come to build a fort on Rock Island...We did not object, however, to their building their fort on the island, but were very sorry, as this was the best one on the Mississippi, and had long been the resort of our young people during

1017-614: A host cell varies across the poxviridae . Recombination of the genome occurs within actively infected cells. Following the onset of viral DNA replication, an intermediate set of genes codes for transcription factors of late gene expression. The products of the later genes include transcription factors necessary for transcribing the early genes for new virions, as well as viral RNA polymerase and other essential enzymes for new viral particles. These proteins are then packaged into new infectious virions capable of infecting other cells. Two live samples of variola major virus remain, one in

1130-735: A host of associated components. Some of the Arsenal's most successful products include the M198 and M119 towed howitzers , and the gun mount for the M1 Abrams , main battle tank for the Army since the 1980s. About 250 military personnel and 6,000 civilians are employed there. The population from the 2020 census was 182 people. From 1816-1862, the site was known as Fort Armstrong. Before that, successive cultures of Native Americans had occupied it for thousands of years because of its strategic position along

1243-601: A potential treatment was effective in killing viral samples. The recommendation could only take effect if approved by the WHA . When the WHA discussed the proposal in 2005, it refrained from taking a formal vote on the proposal, stating that it would review individual research proposals one at a time. Addition of the GFP gene to the Vaccinia genome is routinely performed during research on

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1356-423: A region of roughly 100 base pairs necessary for resolving concatomeric DNA (a stretch of DNA containing multiple copies of the same sequence), a few open reading frames , and short tandemly repeating sequences of varying number and length. The ITRs of poxviridae vary in length across strains and species. The coding sequence for most of the viral proteins in variola major virus have at least 90% similarity with

1469-575: A series of attacks on the Sauk, which practically decimated their people. One such attack, the Battle of Skull Island, occurred on a peninsula in the Saginaw River, which then was called Skull Island. (Its name came from the many skulls and bones supposedly found in mounds on that island over the years.) In this battle, it is said that the Sauk had used their boats to cross part of the river, escape to

1582-421: A source of infection”; noted that “Current recommendations for control of secondary smallpox infections emphasize transmission ‘by expelled droplets to close contacts (those within 6–7 feet)’”; but warned that the “emphasis on spread via large droplets may reduce the vigilance with which more difficult airborne precautions [i.e. against finer droplets capable of traveling longer distances and penetrating deeply into

1695-602: A year. The final known fatal case occurred in the United Kingdom in 1978 . Inoculation for smallpox appears to have started in China around the 1500s. Europe adopted this practice from Asia in the first half of the 18th century. In 1796, Edward Jenner introduced the modern smallpox vaccine. In 1967, the WHO intensified efforts to eliminate the disease. Smallpox is one of two infectious diseases to have been eradicated,

1808-582: Is a severe form accompanied by extensive bleeding into the skin, mucous membranes, gastrointestinal tract, and viscera . This form develops in approximately 2% of infections and occurs mostly in adults. Pustules do not typically form in hemorrhagic smallpox. Instead, bleeding occurs under the skin, making it look charred and black, hence this form of the disease is also referred to as variola nigra or "black pox". Hemorrhagic smallpox has very rarely been caused by variola minor virus. While bleeding may occur in mild cases and not affect outcomes, hemorrhagic smallpox

1921-420: Is also a later form of hemorrhagic smallpox (referred to late hemorrhagic smallpox, or variolosa pustula hemorrhagica ). The prodrome is severe and similar to that observed in early hemorrhagic smallpox, and the fever persists throughout the course of the disease. Bleeding appears in the early eruptive period (but later than that seen in purpura variolosa ), and the rash is often flat and does not progress beyond

2034-490: Is also under research as a viral vector for vaccines for unrelated diseases. The genome of variola major virus was first sequenced in its entirety in the 1990s. The complete coding sequence is publicly available online. The current reference sequence for variola major virus was sequenced from a strain that circulated in India in 1967. In addition, there are sequences for samples of other strains that were collected during

2147-541: Is believed to have had a mortality rate of less than 1%, as compared to variola major's 30%. Like variola major, variola minor was spread through inhalation of the virus in the air, which could occur through face-to-face contact or through fomites. Infection with variola minor virus conferred immunity against the more dangerous variola major virus. Because variola minor was a less debilitating disease than smallpox, people were more frequently ambulant and thus able to infect others more rapidly. As such, variola minor swept through

2260-411: Is caused by infection with variola virus, which belongs to the family Poxviridae , subfamily Chordopoxvirinae , genus Orthopoxvirus . The date of the appearance of smallpox is not settled. It most probably evolved from a terrestrial African rodent virus between 68,000 and 16,000 years ago. The wide range of dates is due to the different records used to calibrate the molecular clock . One clade

2373-488: Is complicated by having multiple infectious forms, with differing mechanisms of cell entry. Poxviruses are unique among human DNA viruses in that they replicate in the cytoplasm of the cell rather than in the nucleus . To replicate, poxviruses produce a variety of specialized proteins not produced by other DNA viruses , the most important of which is a viral-associated DNA-dependent RNA polymerase . Both enveloped and unenveloped virions are infectious. The viral envelope

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2486-447: Is consistent with the other published estimates, it suggests that the archaeological and historical evidence is very incomplete. Better estimates of mutation rates in these viruses are needed. Examination of a strain that dates from c.  1650 found that this strain was basal to the other presently sequenced strains. The mutation rate of this virus is well modeled by a molecular clock. Diversification of strains only occurred in

2599-488: Is little archaeological evidence that the Sauk lived in the Saginaw area. In the early 17th century, when natives told French explorer Samuel de Champlain that the Sauk nation was located on the west shore of Lake Michigan, Champlain mistakenly placed them on the western shore of Lake Huron . This mistake was copied on subsequent maps, and future references identified this as the place of the Sauk. Champlain never visited what

2712-415: Is made of modified Golgi membranes containing viral-specific polypeptides, including hemagglutinin . Infection with either variola major virus or variola minor virus confers immunity against the other. The more common, infectious form of the disease was caused by the variola major virus strain, known for its significantly higher mortality rate compared to its counterpart, variola minor. Variola major had

2825-657: Is now Michigan. Anishinaabe expansion and the Huron attempting to gain regional stability drove the Sac out of their territory. The Huron were armed with guns supplied by their French trading partners. The Sac moved south to territory in parts of what are now northern Illinois and Wisconsin . In the 17th century the Sauk also maintained close relations with the Potawatomi (Pehkînenîha or Shîshîpêhinenîha). This relation has been found by borrowings of Sauk vocabulary that appear in

2938-493: Is rapidly followed by the development of petechiae and bleeding in the skin, conjunctiva and mucous membranes. Death often occurs suddenly between the fifth and seventh days of illness, when only a few insignificant skin lesions are present. Some people survive a few days longer, during which time the skin detaches and fluid accumulates under it, rupturing at the slightest injury. People are usually conscious until death or shortly before. Autopsy reveals petechiae and bleeding in

3051-453: Is typically fatal. Vaccination does not appear to provide any immunity to either form of hemorrhagic smallpox and some cases even occurred among people that were revaccinated shortly before. It has two forms. The early or fulminant form of hemorrhagic smallpox (referred to as purpura variolosa ) begins with a prodromal phase characterized by a high fever, severe headache, and abdominal pain. The skin becomes dusky and erythematous, and this

3164-560: Is unknown, but around the time of the year 1600, they were driven from the area of the St. Lawrence River . Some historians believe that the Sauk migrated to what is now eastern Michigan , where they settled around Saginaw Bay (Ojibwe: Zaagiinaad-wiikwed – "Of the Outlet Bay"). For many years, the Sauk are believed to have prospered in the fertile valley of Saginaw thereafter. They had been driven west by pressure from other tribes, especially

3277-505: Is written oθaakiiwaki in the current orthography. Ojibwe people called them Ozaagii(-wag) . The latter name was transliterated into French and English by European colonists. The neighboring Anishanabeg Ojibwe (Sauk name: Ochipwêwa) and Odawa peoples referred to them by the exonym Ozaagii(-wag) , meaning "those at the outlet". French colonists transliterated that as Sac and the English as "Sauk". The Sauk/Sac called themselves

3390-541: The Oskush/Askasa/Shkasha (male: Shkasha/Oshkashîwiwa , female: Shkashîhkwêwa/Oshkashîhkwêwiwa ) ("the brave"). The two moieties were each symbolized by two colors: The Askasa/Shkasha painted their faces and partly their bodies with charcoal in mahkatêwâwi (black) and the Ki-sko-ha/Kîshkôha painted their bodies with white clay in wâpeshkyâwi (white). This duality was also celebrated by

3503-508: The autonym of Othâkîwa, Thâkîwa, Thâkîwaki or Asaki-waki/Oθaakiiwaki people of the yellow earth [("people coming forth [from the outlet]," i.e., "from the water")], which is often interpreted to mean "yellow-earth people" or "the Yellow-Earths", due to the yellow-clay soils found around Saginaw Bay. This interpretation possibly derived from the Sauk words Athâwethiwa or Athâw(i) ("yellow") and Neniwaki ("men, people"). This

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3616-698: The East India Company stationed in China and another by Clopton Havers . Lady Mary Wortley Montagu observed smallpox inoculation during her stay in the Ottoman Empire , writing detailed accounts of the practice in her letters, and enthusiastically promoted the procedure in England upon her return in 1718. According to Voltaire (1742), the Turks derived their use of inoculation from neighbouring Circassia . Voltaire does not speculate on where

3729-597: The New World , resulting in large swathes of Native Americans dying . In 18th-century Europe, it is estimated that 400,000 people died from the disease per year, and that one-third of all cases of blindness were due to smallpox. Smallpox is estimated to have killed up to 300 million people in the 20th century and around 500 million people in the last 100 years of its existence. Earlier deaths included six European monarchs , including Louis XV of France in 1774. As recently as 1967, 15 million cases occurred

3842-691: The Potawatomi language . In a loose coalition of tribes – including Dakota (Ashâha), Ho-Chunk , Ojibwe, Odawa, Potawatomi, Kickapoo (Kîkâpôwa), Meskwaki (Fox), and Sauk, along with the Shawnee (Shâwanôwa), Cherokee (Shanahkîha), and Choctaw (Châkitâha) from the Southeast – they attacked the tribes of the Illinois Confederation (Mashkotêwa) and tried to invade their tribal areas. The Illinois (Inoca) became their worst common enemies. The coalition warred for years until they destroyed

3955-764: The United States . In 1988 the Arsenal was designated a National Historic Landmark . At the turn of the 20th century, it manufactured both ordnance and leather accoutrements and field gear, for an army that still relied on horses for transportation and cavalry. Today it provides manufacturing , logistics , and base support services for the United States Armed Forces . The Arsenal is the only active U.S. Army foundry, and manufactures ordnance and equipment, including artillery , gun mounts , recoil mechanisms , small arms , aircraft weapons sub-systems, grenade launchers , weapons simulators , and

4068-422: The common cold : fever of at least 38.3 °C (101 °F), muscle pain , malaise , headache and fatigue. As the digestive tract was commonly involved, nausea, vomiting, and backache often occurred. The early prodromal stage usually lasted 2–4 days. By days 12–15, the first visible lesions – small reddish spots called enanthem – appeared on mucous membranes of the mouth, tongue, palate , and throat, and

4181-470: The horsepox virus using publicly available sequence data for horsepox. The researchers argued that their work would be beneficial to creating a safer and more effective vaccine for smallpox, although an effective vaccine is already available. The horsepox virus had previously seemed to have gone extinct, raising concern about potential revival of variola major and causing other scientists to question their motives. Critics found it especially concerning that

4294-468: The replication of viral DNA. The first set of expressed genes are transcribed by pre-existing viral machinery packaged within the infecting virion. These genes encode the factors necessary for viral DNA synthesis and for transcription of the next set of expressed genes. Unlike most DNA viruses, DNA replication in variola virus and other poxviruses takes place within the cytoplasm of the infected cell. The exact timing of DNA replication after infection of

4407-624: The 18th and 19th centuries. Variola virus is large and brick-shaped and is approximately 302 to 350 nanometers by 244 to 270 nm, with a single linear double stranded DNA genome 186 kilobase pairs (kbp) in size and containing a hairpin loop at each end. Four orthopoxviruses cause infection in humans: variola, vaccinia , cowpox , and monkeypox . Variola virus infects only humans in nature, although primates and other animals have been infected in an experimental setting. Vaccinia, cowpox, and monkeypox viruses can infect both humans and other animals in nature. The life cycle of poxviruses

4520-779: The Circassians derived their technique from, though he reports that the Chinese have practiced it "these hundred years". In 1721, Cotton Mather and colleagues provoked controversy in Boston by inoculating hundreds. After publishing The present method of inoculating for the small-pox in 1767, Dr Thomas Dimsdale was invited to Russia to variolate the Empress Catherine the Great of Russia and her son, Grand Duke Paul , which he successfully did in 1768. In 1796, Edward Jenner ,

4633-692: The Dakota, Pawnee (Pânîha) and, most of all, the powerful Osage (Washâsha). The Sauk had good relations with the English (Thâkanâsha) through trading. At first, the Sauk had good relations with New France too, until their alliance with the Meskwaki (Fox) made them short-term enemies of the French (Mêmehtekôshîha, Wêmehtekôshîha). A closely allied tribe, the Meskwaki (Fox) , were noted for resisting French encroachment, having fought two wars against them in

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4746-639: The Dawes Act purposely broke collective tribal lands into small allotments designated for individual households. The remainder of land not allotted to the Sac and Fox was then sold to non-Native settlers in an attempt to gain Oklahoma statehood and the full assimilation of its Native American population. By 1889, 519 of the tribe were located in Indian Territory, what is now central Oklahoma. On June 10, 1891, they ceded these Indian Territory lands to

4859-500: The Illinois Confederation. Later they moved out on the prairie (Mashkotêwi) along the Mississippi and adopted the semi-sedentary lifestyle of Plains Indians (Mashkotêwineniwa). In addition to hunting buffalo , they lived in villages, raised crops, and actively traded with other tribes. The Sauk and allied eastern tribes had to compete with tribes who already occupied this territory. Disputes and clashes arose with

4972-754: The Mississippi River. The United States took control of the island in 1804 through the Harrison Peace Treaty with the Chief of the Fox and Sac Tribes. From 1804 to 1812 the US Army did not occupy the island. It was the scene of a small conflict at the outbreak of the War of 1812 with Great Britain. Following that war, in 1814 it was the site of a U.S. Army expedition from St Louis to use the island as

5085-462: The Sauk. At first, Keokuk accepted the loss of land as inevitable in the face of the vast numbers of white soldiers and settlers coming west. He tried to preserve tribal land and his people, and to keep the peace. Having failed to receive expected supplies from the Americans on credit, Black Hawk wanted to fight, saying his people were "forced into war by being deceived". Led by Black Hawk in 1832,

5198-833: The United States at the CDC in Atlanta, and one at the Vector Institute in Koltsovo, Russia. Research with the remaining virus samples is tightly controlled, and each research proposal must be approved by the WHO and the World Health Assembly (WHA). Most research on poxviruses is performed using the closely related Vaccinia virus as a model organism. Vaccinia virus, which is used to vaccinate for smallpox,

5311-565: The United States, Great Britain, and South Africa in the early 20th century, becoming the dominant form of the disease in those areas and thus rapidly decreasing mortality rates. Along with variola major, the minor form has now been totally eradicated from the globe. The last case of indigenous variola minor was reported in a Somali cook, Ali Maow Maalin, in October 1977, and smallpox was officially declared eradicated worldwide in May 1980. Variola minor

5424-531: The WHO eradication campaign. A genome browser for a complete database of annotated sequences of variola virus and other poxviruses is publicly available through the Viral Bioinformatics Resource Center . The WHO currently bans genetic engineering of the variola virus. However, in 2004, a committee advisory to the WHO voted in favor of allowing editing of the genome of the two remaining samples of variola major virus to add

5537-507: The absence of Guarnieri bodies could not be used to rule out smallpox. The diagnosis of an orthopoxvirus infection can also be made rapidly by electron microscopic examination of pustular fluid or scabs. All orthopoxviruses exhibit identical brick-shaped virions by electron microscopy. If particles with the characteristic morphology of herpesviruses are seen this will eliminate smallpox and other orthopoxvirus infections. Definitive laboratory identification of variola virus involved growing

5650-566: The area include the Confederate Cemetery, the Rock Island National Cemetery , 19th-century stone workshops, officers' quarters along the river, Col. Davenport's House, and the site of the first railroad bridge built across the Mississippi . Following the war, the federal government retained ownership of Arsenal Island. It developed it for use as an arsenal and ordnance manufacturing center, which led to

5763-448: The bloodstream in large numbers, a condition known as viremia . This resulted in the second wave of multiplication in the spleen , bone marrow , and lymph nodes. The clinical definition of ordinary smallpox is an illness with acute onset of fever equal to or greater than 38.3 °C (101 °F) followed by a rash characterized by firm, deep-seated vesicles or pustules in the same stage of development without other apparent cause. When

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5876-477: The central region of the genome is highly consistent across orthopoxviruses , and the arrangement of genes is consistent across chordopoxviruses. The center of the variola virus genome contains the majority of the essential viral genes, including the genes for structural proteins , DNA replication , transcription , and mRNA synthesis. The ends of the genome vary more across strains and species of orthopoxviruses . These regions contain proteins that modulate

5989-516: The characteristic fluid-filled blisters with a dent in the center. The bumps then scabbed over and fell off, leaving scars. The disease was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person or rarely via contaminated objects . Prevention was achieved mainly through the smallpox vaccine . Once the disease had developed, certain antiviral medications could potentially have helped, but such medications did not become available until after

6102-405: The civil chiefs were hereditary. The other two chiefs were recognized by bands after they demonstrated their ability or spiritual power. This traditional manner of selecting historic clan chiefs and governance was replaced in the 19th century by the United States appointing leaders through their agents at the Sac and Fox Agency, or reservation in Indian Territory (now Oklahoma). In the 20th century,

6215-503: The closely related Vaccinia virus . The public availability of the variola virus complete sequence has raised concerns about the possibility of illicit synthesis of infectious virus. Vaccinia , a cousin of the variola virus, was artificially synthesized in 2002 by NIH scientists. They used a previously established method that involved using a recombinant viral genome to create a self-replicating bacterial plasmid that produced viral particles. In 2016, another group synthesized

6328-621: The course of the illness, but this happened most frequently during the first week of the rash when most of the skin lesions were intact. Infectivity waned in 7 to 10 days when scabs formed over the lesions, but the infected person was contagious until the last smallpox scab fell off. Concern about possible use of smallpox for biological warfare led in 2002 to Donald K. Milton's detailed review of existing research on its transmission and of then-current recommendations for controlling its spread. He agreed, citing Rao, Fenner and others, that “careful epidemiologic investigation rarely implicated fomites as

6441-403: The diagnosis of infection. Chickenpox was commonly confused with smallpox in the immediate post-eradication era. Chickenpox and smallpox could be distinguished by several methods. Unlike smallpox, chickenpox does not usually affect the palms and soles. Additionally, chickenpox pustules are of varying size due to variations in the timing of pustule eruption: smallpox pustules are all very nearly

6554-512: The disease was eradicated. The risk of death was about 30%, with higher rates among babies. Often, those who survived had extensive scarring of their skin, and some were left blind. The earliest evidence of the disease dates to around 1500 BC in Egyptian mummies . The disease historically occurred in outbreaks . It was one of several diseases introduced by the Columbian exchange to

6667-461: The early 18th century. After a devastating battle of September 9, 1730, in Illinois, in which hundreds of warriors were killed and many women and children taken captive by French allies, Fox refugees took shelter with the Sac. This made the Sauk subject to French attack in turn. The Sauk continued moving west to Iowa and Kansas . Keokuk and Black Hawk were two important leaders who arose among

6780-572: The federal government. Many of the latter treaties listed have little to no information regarding their details, besides the date. The Sauk signed a total of 39 treaties from 1758 to 1891 The Sauk and Fox peoples were divided into two moieties or "divisions", which in turn were subdivided into Patri-lineages and Clans as local subgroups (segments). The moieties were known as the Kishko/Ki-sko-ha/Kîshkôha (male: Kîshkôha , female: Kîshkôhkwêha ) ("the long-haired") and as

6893-408: The genome of vaccinia , a related virus used for vaccination against smallpox. Gene expression of variola virus occurs entirely within the cytoplasm of the host cell , and follows a distinct progression during infection. After entry of an infectious virion into a host cell, synthesis of viral mRNA can be detected within 20 minutes. About half of the viral genome is transcribed prior to

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7006-429: The group was able to recreate viable virus in a short time frame with relatively little cost or effort. Although the WHO bans individual laboratories from synthesizing more than 20% of the genome at a time, and purchases of smallpox genome fragments are monitored and regulated, a group with malicious intentions could compile, from multiple sources, the full synthetic genome necessary to produce viable virus. Smallpox

7119-621: The history of Rock Island Arsenal and the Union prison camp during the American Civil War , and the site's role as a military industrial facility. The museum contains the second-largest collection of small arms weapons in the U.S. Army, and an outdoor vehicle display. Sauk people The Sauk or Sac are Native Americans and Indigenous peoples of the Northeastern Woodlands . Their historical territory

7232-498: The hosts' immune systems, and are primarily responsible for the variability in virulence across the orthopoxvirus family. These terminal regions in poxviruses are inverted terminal repetitions (ITR) sequences. These sequences are identical but oppositely oriented on either end of the genome, leading to the genome being a continuous loop of DNA. Components of the ITR sequences include an incompletely base paired A/T rich hairpin loop ,

7345-560: The island being renamed. During the First World War, demand for war materials drastically increased; this increased the demand for skilled labor, but many men were drafted for the war. Women were hired to fill job vacancies at the arsenal. This is often referred to as the "women draft", as they had to backfill the men leaving to fight in order to keep satisfying the war demands from factory production. Rock Island Arsenal increased from having 175 female employees in 1914 to 300 in 1917,

7458-456: The island, and were temporarily free from their attackers. But when morning came, ice had solidified the river enough for the Ojibwe to cross. They killed every member of the Sauk tribe who had fled to that island besides 12 women whom they later sent west of the Mississippi River. But later Europeans may have mistakenly recorded the Sauk as once dwelling at this location near Lake Huron . There

7571-436: The lesions remained almost flush with the skin at the time when raised vesicles would have formed in the ordinary type. It is unknown why some people developed this type. Historically, it accounted for 5–10% of cases, and most (72%) were children. Malignant smallpox was accompanied by a severe prodromal phase that lasted 3–4 days, prolonged high fever, and severe symptoms of viremia . The prodromal symptoms continued even after

7684-406: The lower respiratory tract] are maintained”. Once inhaled, the variola virus invaded the mucous membranes of the mouth, throat, and respiratory tract. From there, it migrated to regional lymph nodes and began to multiply. In the initial growth phase, the virus seemed to move from cell to cell, but by around the 12th day, widespread lysis of infected cells occurred and the virus could be found in

7797-473: The mainly Sac band resisted the continued loss of lands (in western Illinois, this time.) Their warfare with United States forces resulted in defeat at the hands of General Edmund P. Gaines in the Black Hawk War . From 1832 to 1837, debt and poverty were tools used to coerce the Sauk and Meskwaki to relocate three times following successive cessions of territory. The population of the two tribes living in Iowa

7910-408: The malignant and hemorrhagic forms were usually fatal. The modified form was almost never fatal. In early hemorrhagic cases, hemorrhages occurred before any skin lesions developed. The incubation period between contraction and the first obvious symptoms of the disease was 7–14 days. At least 90% of smallpox cases among unvaccinated persons were of the ordinary type. In this form of the disease, by

8023-599: The mouth of the Rock River ( Sinnissippi – "rocky waters") into the Mississippi ( Mäse'sibowi – "great river"), the most important Sauk settlement in the 18th and 19th centuries with about 4,000 inhabitants, was divided into 12 districts, which were assigned to the respective clans. The tribe was governed by a council of sacred clan chiefs, a war chief, the head of families, and the warriors. Chiefs were recognized in three categories: civil, war, and ceremonial. Only

8136-404: The onset of the rash. The rash on the mucous membranes ( enanthem ) was extensive. Skin lesions matured slowly, were typically confluent or semi-confluent, and by the seventh or eighth day, they were flat and appeared to be buried in the skin. Unlike ordinary-type smallpox, the vesicles contained little fluid, were soft and velvety to the touch, and may have contained hemorrhages. Malignant smallpox

8249-429: The oral, nasal, or pharyngeal mucosa of an infected person. It was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person. Some infections of laundry workers with smallpox after handling contaminated bedding suggested that smallpox could be spread through direct contact with contaminated objects ( fomites ), but this was found to be rare. Also rarely, smallpox

8362-464: The other being rinderpest (a disease of even-toed ungulates ) in 2011. The term "smallpox" was first used in England in the 16th century to distinguish the disease from syphilis , which was then known as the "great pox". Other historical names for the disease include pox, speckled monster, and red plague. The United States and Russia retain samples of variola virus in laboratories, which has sparked debates over safety . There are two forms of

8475-523: The outer layers of skin from the underlying flesh. Patients with confluent smallpox often remained ill even after scabs had formed over all the lesions. In one case series, the case-fatality rate in confluent smallpox was 62%. Referring to the character of the eruption and the rapidity of its development, modified smallpox occurred mostly in previously vaccinated people. It was rare in unvaccinated people, with one case study showing 1–2% of modified cases compared to around 25% in vaccinated people. In this form,

8588-588: The person was infected with variola virus, a severe infection could result, and the person could transmit smallpox to others. Variolation had a 0.5–2 percent mortality rate, considerably less than the 20–30 percent mortality rate of smallpox. Two reports on the Chinese practice of inoculation were received by the Royal Society in London in 1700; one by Dr. Martin Lister who received a report by an employee of

8701-429: The power of the Mississippi River. A total of 1,964 Confederate prisoners and 125 Union guards are buried in the adjacent military cemetery. The Union guard burials included 49 members of the 108th Regiment of United States Colored Troops , who had served as guards. Most of the men died from disease, since sanitation was primitive, as in all army encampments. In addition, they were exposed to high heat and humidity during

8814-547: The powerful Haudenosaunee , which sought control over hunting grounds in the area. Some Ojibwe oral histories also place the Sauk in the Saginaw Valley some time before the arrival of Europeans. Sauk traditions state that the tribe occupied the vicinity of Saginaw river. (In this tradition, the name 'Saginaw' comes from the Ojibwe "O-Sauk-e-non," meaning "land of the Sauks" or "where the Sauks were.") Approximately from

8927-497: The practice arrived in Europe. The idea that inoculation originated in India has been challenged, as few of the ancient Sanskrit medical texts described the process of inoculation. Accounts of inoculation against smallpox in China can be found as early as the late 10th century, and the procedure was widely practiced by the 16th century, during the Ming dynasty . If successful, inoculation produced lasting immunity to smallpox. Because

9040-491: The prodromal illness still occurred but may have been less severe than in the ordinary type. There was usually no fever during the evolution of the rash. The skin lesions tended to be fewer and evolved more quickly, were more superficial, and may not have shown the uniform characteristic of more typical smallpox. Modified smallpox was rarely, if ever, fatal. This form of variola major was more easily confused with chickenpox . In malignant-type smallpox (also called flat smallpox)

9153-544: The river in the aftermath of the War of 1812 with Great Britain. Decades after the Civil War, in the 1880s the army established a foundry and armory here, manufacturing both military equipment and ordnance. In 1919–1920 one hundred of the Anglo-American or Liberty Mark VIII tanks were manufactured there, although too late for World War I. The base is now the largest government-owned weapons manufacturing arsenal in

9266-454: The same size since the viral effect progresses more uniformly. A variety of laboratory methods were available for detecting chickenpox in the evaluation of suspected smallpox cases. The earliest procedure used to prevent smallpox was inoculation with variola minor virus (a method later known as variolation after the introduction of smallpox vaccine to avoid possible confusion), which likely occurred in India, Africa, and China well before

9379-479: The second day of the rash the macules had become raised papules . By the third or fourth day, the papules had filled with an opalescent fluid to become vesicles . This fluid became opaque and turbid within 24–48 hours, resulting in pustules . By the sixth or seventh day, all the skin lesions had become pustules. Between seven and ten days the pustules had matured and reached their maximum size. The pustules were sharply raised, typically round, tense, and firm to

9492-491: The separation of variola virus from Taterapox (an Orthopoxvirus of some African rodents including gerbils ) at 3,000 to 4,000 years ago. This is consistent with archaeological and historical evidence regarding the appearance of smallpox as a human disease which suggests a relatively recent origin. If the mutation rate is assumed to be similar to that of the herpesviruses , the divergence date of variola virus from Taterapox has been estimated to be 50,000 years ago. While this

9605-445: The shores of Lake Osakis. They had been banished from their tribe for murder. According to Anishinaabe oral tradition, these five Sac were killed by local Dakota in the late 18th century. Place names with "Sauk" references include: Smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to the genus Orthopoxvirus . The last naturally occurring case

9718-427: The smallpox. Variola major is the severe and most common form, with a more extensive rash and higher fever. Variola minor is a less common presentation, causing less severe disease, typically discrete smallpox, with historical death rates of 1% or less. Subclinical ( asymptomatic ) infections with variola virus were noted but were not common. In addition, a form called variola sine eruptione (smallpox without rash)

9831-520: The spleen, kidney, serous membranes , skeletal muscles, pericardium , liver, gonads and bladder. Historically, this condition was frequently misdiagnosed, with the correct diagnosis made only at autopsy. This form is more likely to occur in pregnant women than in the general population (approximately 16% of cases in unvaccinated pregnant women were early hemorrhagic smallpox, versus roughly 1% in nonpregnant women and adult males). The case fatality rate of early hemorrhagic smallpox approaches 100%. There

9944-473: The summer. It was our garden, like the white people have near their big villages, which supplied us with strawberries, blackberries, gooseberries, plums, apples and nuts of different kinds." During the Civil War, the army converted some facilities and built more in 1863; these were not yet completed in December of that year, when the first Confederate prisoners of war were incarcerated there. The construction

10057-413: The summers and freezing temperatures during winters. In 1864, deadly smallpox epidemics rapidly spread through the prison. The prison camp operated from December 1863 until July 1865, when the last prisoners were freed. After the war, the prison facility was completely destroyed. During its two years in operation, the prison camp housed a total of more than 12,400 Confederates. Other historical sites in

10170-964: The supporters of the Republican Party are associated with the Shkasha/Shkashîhkwêwa . Originally, the Sauk had a patrilineal and exogamous clan system , in which descent and inheritance was traced through the father. Clans or Mîthonî distinguished and named on the basis of totem animals, which are: Mahkwithowa (Bear Clan), Amehkwithowa (Beaver Clan), Peshekethiwithowa (Deer Clan), Ketiwithowa / Mekethiwithowa (Eagle Clan), Nemêthithowa (Fish Clan), Wâkoshêhithowa (Fox Clan), Kehchikamîwithowa (Ocean/Sea/Great Lake Clan), Keshêhokimâwithowa (Peace Clan), Ahpenîthowa (Potato Clan), Akônithowa (Snow Clan), Nenemehkiwithowa (Thunder Clan), Manethenôkimâwithowa (Warrior Clan), and Mahwêwithowa (Wolf Clan). Saukenuk or Saukietown (today: Black Hawk State Historic Site ) near

10283-425: The temperature fell to near-normal. These lesions rapidly enlarged and ruptured, releasing large amounts of virus into the saliva. Variola virus tended to attack skin cells, causing the characteristic pimples, or macules , associated with the disease. A rash developed on the skin 24 to 48 hours after lesions on the mucous membranes appeared. Typically the macules first appeared on the forehead, then rapidly spread to

10396-411: The touch. The pustules were deeply embedded in the dermis, giving them the feel of a small bead in the skin. Fluid slowly leaked from the pustules, and by the end of the second week, the pustules had deflated and began to dry up, forming crusts or scabs. By day 16–20 scabs had formed over all of the lesions, which had started to flake off, leaving depigmented scars. Ordinary smallpox generally produced

10509-482: The tribe adopted a constitutional government patterned after the United States form. They elect their chiefs. Today, the federally recognized Sac and Fox tribes include: Lake Osakis in west-central Minnesota , the Sauk River , ^ which flows from Lake Osakis, and the towns of Osakis , Sauk Centre , and Sauk Rapids all were named for association historically with a small party of Sac who made camp on

10622-673: The two moieties in Lacrosse , which was often played extremely brutally to toughen young warriors for combat, for recreation, as part of festivals, and used as preparation for imminent wars or raids. This division has survived to the present day, but is now more related to the political system of the United States: the supporters of the Democratic Party are associated with the Kîshkôha/Kîshkôhkwêha , while

10735-621: The two tribes together since their residency in the Midwest. A number of Meskwaki returned to the Midwest from Oklahoma (or resisted leaving.) They joined the Meskwaki at the Meskwaki Settlement in Tama County, Iowa . The land currently occupied by the Sauk is only a section of what used to be the Sac and Fox Reservation from 1867 to 1891. This reservation was established by the U.S. and spanned 480,000 acres. In 1886, however,

10848-475: The vesicular stage. Hemorrhages in the mucous membranes appear to occur less often than in the early hemorrhagic form. Sometimes the rash forms pustules which bleed at the base and then undergo the same process as in ordinary smallpox. This form of the disease is characterized by a decrease in all of the elements of the coagulation cascade and an increase in circulating antithrombin . This form of smallpox occurs anywhere from 3% to 25% of fatal cases, depending on

10961-439: The virulence of the smallpox strain. Most people with the late-stage form die within eight to 10 days of illness. Among the few who recover, the hemorrhagic lesions gradually disappear after a long period of convalescence. The case fatality rate for late hemorrhagic smallpox is around 90–95%. Pregnant women are slightly more likely to experience this form of the disease, though not as much as early hemorrhagic smallpox. Smallpox

11074-442: The virus on chorioallantoic membrane (part of a chicken embryo ) and examining the resulting pock lesions under defined temperature conditions. Strains were characterized by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Serologic tests and enzyme linked immunosorbent assays (ELISA), which measured variola virus-specific immunoglobulin and antigen were also developed to assist in

11187-554: The whole face, proximal portions of extremities, the trunk, and lastly to distal portions of extremities. The process took no more than 24 to 36 hours, after which no new lesions appeared. At this point, variola major disease could take several very different courses, which resulted in four types of smallpox disease based on the Rao classification: ordinary, modified, malignant (or flat), and hemorrhagic smallpox. Historically, ordinary smallpox had an overall fatality rate of about 30%, and

11300-517: The years 1638 to 1640, it is believed that a fierce battle ensued, nearly annihilating the entire Sauk Tribe. According to the legend, the Ojibwe inhabited the lands north of the Saginaw Bay, and the harsher northern climate caused more difficulty in prosperity compared to that of the Sauk occupying the area of Saginaw Valley. The Ojibwe allied with the Odawa, who resided south of the Sauk, and sprung

11413-431: Was also called white pox, kaffir pox, Cuban itch, West Indian pox, milk pox, and pseudovariola. The genome of variola major virus is about 186,000 base pairs in length. It is made from linear double stranded DNA and contains the coding sequence for about 200 genes . The genes are usually not overlapping and typically occur in blocks that point towards the closer terminal region of the genome. The coding sequence of

11526-478: Was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, making smallpox the only human disease to have been eradicated to date. The initial symptoms of the disease included fever and vomiting. This was followed by formation of ulcers in the mouth and a skin rash . Over a number of days, the skin rash turned into

11639-517: Was halved in the twelve years from 1833 to 1845. About this time, one group of Sac moved into Missouri, and later to Kansas and Nebraska. In 1869, after the Civil War, the United States forced the larger group of Sac to move into a reservation in Indian Territory (now the state of Oklahoma ). They formed the federally recognized Sac and Fox Nation , which is misnamed and is primarily Sauk. The United States had been making treaties with

11752-428: Was highly contagious, but generally spread more slowly and less widely than some other viral diseases, perhaps because transmission required close contact and occurred after the onset of the rash. The overall rate of infection was also affected by the short duration of the infectious stage. In temperate areas, the number of smallpox infections was highest during the winter and spring. In tropical areas, seasonal variation

11865-465: Was later shortened to "Asaki-waki". In addition, the Fox (Meskwaki) were generally known among neighboring tribes as the "people of the red earth" - the Sauk and Fox also used this term: Êshkwîha or Meshkwahkîha ("people of the red earth"). The Sauk, an Algonquian languages people, are believed to have developed as a people along the St. Lawrence River , which is now northern New York. The precise time

11978-442: Was less evident and the disease was present throughout the year. Age distribution of smallpox infections depended on acquired immunity . Vaccination immunity declined over time and was probably lost within thirty years. Smallpox was not known to be transmitted by insects or animals and there was no asymptomatic carrier state. Transmission occurred through inhalation of airborne variola virus, usually droplets expressed from

12091-417: Was makeshift. The first prisoners were 468 Confederates captured in battles at Chattanooga, Tennessee . That month more than 5,000 Confederates would swell the population of Rock Island military prison. They were kept in 84 barracks, each holding around 100 prisoners. A total of 41 Confederate prisoners successfully escaped during the prison's operation, and many more would try but fail. They were deterred by

12204-470: Was near Green Bay, Wisconsin . Today they have three tribes based in Iowa, Kansas, Nebraska, and Oklahoma. Their federally recognized tribes are: They are closely allied with the Meskwaki people. Their Sauk language is part of the Algonquian language family . The Sauk or Sac called themselves Thâkîwaki, translating as "people coming forth [from the outlet]" or "[from the water]". Their autonym

12317-421: Was nearly always fatal and death usually occurred between the 8th and 12th day of illness. Often, a day or two before death, the lesions turned ashen gray, which, along with abdominal distension, was a bad prognostic sign. This form is thought to be caused by deficient cell-mediated immunity to smallpox. If the person recovered, the lesions gradually faded and did not form scars or scabs. Hemorrhagic smallpox

12430-456: Was seen generally in vaccinated persons. This form was marked by a fever that occurred after the usual incubation period and could be confirmed only by antibody studies or, rarely, by viral culture . In addition, there were two very rare and fulminating types of smallpox, the malignant (flat) and hemorrhagic forms, which were usually fatal. The initial symptoms were similar to other viral diseases that are still extant, such as influenza and

12543-440: Was spread by virus carried in the air in enclosed settings such as buildings, buses, and trains. The virus can cross the placenta , but the incidence of congenital smallpox was relatively low. Smallpox was not notably infectious in the prodromal period and viral shedding was usually delayed until the appearance of the rash, which was often accompanied by lesions in the mouth and pharynx. The virus can be transmitted throughout

12656-404: Was the primary cause of smallpox outbreaks across Asia and most of Africa. Meanwhile, variola minor was more commonly found in regions of Europe, North America, South America, and certain parts of Africa. Variola minor virus, also called alastrim, was a less common form of the virus, and much less deadly. Although variola minor had the same incubation period and pathogenetic stages as smallpox, it

12769-516: Was the variola major strains (the more clinically severe form of smallpox) which spread from Asia between 400 and 1,600 years ago. A second clade included both alastrim (a phenotypically mild smallpox) described from the American continents and isolates from West Africa which diverged from an ancestral strain between 1,400 and 6,300 years before present. This clade further diverged into two subclades at least 800 years ago. A second estimate has placed

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