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156-518: The Western Bank Campus is the main campus of the University of Sheffield . It lies one mile to the west of Sheffield city centre and is bounded by Upper Hanover Street to the east, Glossop Road to the south, Clarkson Street to the west, and Bolsover Street to the north. The campus includes Firth Court, Alfred Denny Building, Western Bank library and Arts Tower, Geography and Planning building, Bartolomé House, Dainton and Richard Roberts Buildings,

312-415: A Rasmussen aneurysm , resulting in massive bleeding. Tuberculosis may become a chronic illness and cause extensive scarring in the upper lobes of the lungs. The upper lung lobes are more frequently affected by tuberculosis than the lower ones. The reason for this difference is not clear. It may be due to either better air flow, or poor lymph drainage within the upper lungs. In 15–20% of active cases,

468-463: A capacity of 1,600, offices, meeting rooms, and a lounge with bar and patio. The University Grants Committee agreed to construct a new oval shaped theatre in 1958 next to University House . The plan was suspended in 1963, and instead, the Drama Studio was refurbished from the former Glossop Road Baptist Church and opened in 1970 as a studio theatre. In 1981, the university had made plans to build

624-472: A circular arcade with compound piers and transoms containing portraits of university benefactors. It is linked to the main block via a glazed corridor. The Firth Court quadrangle, comprising Firth Hall Block, North Block, West Block, and Florey and Addison buildings, was completed in 1914 also by Gibbs. Gibbs planned to build a double quadrangle but was never happened. During the Second World War,

780-569: A common ancestor, remains unclear. A comparison of the genes of M. tuberculosis complex (MTBC) in humans to MTBC in animals suggests humans did not acquire MTBC from animals during animal domestication, as researchers previously believed. Both strains of the tuberculosis bacteria share a common ancestor, which could have infected humans even before the Neolithic Revolution . Skeletal remains show some prehistoric humans (4000 BC ) had TB, and researchers have found tubercular decay in

936-610: A courtyard, dedicated café and Employability Hub. The Information School (iSchool) is a constituent school of the Faculty of Social Sciences. It was founded as Postgraduate School of Librarianship in 1963 and became the Department of Information Studies in 1981. In 2010, the Information School devoting to the study of the information field was established. The current head of school is Professor Peter Bath. The school

1092-645: A library and computing centre opened in 2007, is also located at the Western Bank Campus on Leavygreave Road. In addition, throughout 2010 the Western Bank Library received a £3.3 million restoration and refurbishment, the University of Sheffield Union of Students underwent a £5 million rebuild, and work commenced on a multimillion-pound refurbishment of the Grade II* listed Arts Tower to extend its lifespan by 30 years. To

1248-685: A microscope. Since MTB retains certain stains even after being treated with acidic solution, it is classified as an acid-fast bacillus . The most common acid-fast staining techniques are the Ziehl–Neelsen stain and the Kinyoun stain , which dye acid-fast bacilli a bright red that stands out against a blue background. Auramine-rhodamine staining and fluorescence microscopy are also used. The M. tuberculosis complex (MTBC) includes four other TB-causing mycobacteria : M. bovis , M. africanum , M. canettii , and M. microti . M. africanum

1404-452: A new medical school. The Sheffield Medical Institution was formally opened a year later in 1829 on Surrey Street, with the Latin motto Ars longa vita brevis (Art is long, life is short), which refers to the difficulty to acquire and practice the art of Medicine. Knight laid the foundation stone and delivered the opening lecture. The University Extension Movement emerged in the 1870s with

1560-530: A new pedestrian crossing was installed on the Upper Hanover Street, physically connecting the two campus. The university campus is composed of an eclectic range of buildings from Victorian style to modernism to contemporary . Sir Frederick Mappin Building and Central Block are two Victorian university buildings, now linked by a contemporary curved glass roof constructed in 2020. Opened as

1716-536: A new premises and the Octagon Centre building was eventually opened in 1983. The Octagon Centre consists of a main auditorium known as the Convocation Hall, with offices and meeting rooms in corridors across two floors at a lower elevation on the southern side of the building, and a bar lounge. All of these areas are connected by a foyer entrance block. The building is connected to University House by

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1872-678: A sheaf of eight silver arrows on either side (from the arms of the city), the Crown of Success and the White Rose of York . Below is a scroll carrying the motto Rerum cognoscere causas (To Discover the Causes of Things; from the Georgics by Latin poet Virgil ), which was also the motto of Firth College since 1879. In heraldic terminology, the official coat of arms is blazoned as follows: Azure, an open book proper, edged gold, inscribed with

2028-555: A single centre, since receiving its royal charter, the university has expanded from two academic foci about 1 km apart: Firth Court on Western Bank and Sir Frederick Mappin Building on St George's. The two foci started to fuse in the 1960s, as more buildings have been constructed or acquired by the university. The completion of the Information Commons and Jessop West buildings, in the late 2000s, bridges both west (Western Bank) and east (St George's) campus, and in 2017,

2184-529: A skyway, offering access to University House's catering facilities. The Hicks Building is a building named after William Mitchinson Hicks, a British mathematician and physicist who spent most of his career at Sheffield, contributing to the development of the university. It houses the departments of Physics and Astronomy, the Chemistry and Physics Workshop and the School of Mathematics and Statistics. The building

2340-407: A small decrease in case numbers. Some countries have legislation to involuntarily detain or examine those suspected to have tuberculosis, or involuntarily treat them if infected. The only available vaccine as of 2021 is bacillus Calmette-Guérin (BCG). In children it decreases the risk of getting the infection by 20% and the risk of infection turning into active disease by nearly 60%. It

2496-401: A tuberculosis infection does become active, it most commonly involves the lungs (in about 90% of cases). Symptoms may include chest pain and a prolonged cough producing sputum. About 25% of people may not have any symptoms (i.e., they remain asymptomatic). Occasionally, people may cough up blood in small amounts, and in very rare cases, the infection may erode into the pulmonary artery or

2652-728: A university in the city. As a first stage of his ideal, Hicks was devoted to the union of the three higher education institutions in Sheffield and to transform Firth College into a university college . He also extended the college by creating new departments and adding new buildings. In 1897, Firth College merged with the Medical School and the Technical School to form the University College of Sheffield, and Hicks served as its first principal. Six years since

2808-398: Is Mycobacterium tuberculosis (MTB), a small, aerobic , nonmotile bacillus . The high lipid content of this pathogen accounts for many of its unique clinical characteristics. It divides every 16 to 20 hours, which is an extremely slow rate compared with other bacteria, which usually divide in less than an hour. Mycobacteria have an outer membrane lipid bilayer. If a Gram stain

2964-432: Is spread from one person to the next through the air when people who have active TB in their lungs cough, spit, speak, or sneeze . People with latent TB do not spread the disease. Active infection occurs more often in people with HIV/AIDS and in those who smoke . Diagnosis of active TB is based on chest X-rays , as well as microscopic examination and culture of bodily fluids. Diagnosis of latent TB relies on

3120-450: Is a Grade II* listed building opened in 1966. It was the tallest structure in Sheffield from 1965 to 2010, and is the tallest university building in the UK. The building, previously housed several academic departments, is now mainly an administration block and has the architecture department in it. The Arts Tower houses one of Europe's few surviving examples of a paternoster lift . A bridge at

3276-704: Is a Grade II-listed building in an area known as the St George's Complex. The building houses much of the Faculty of Engineering and St George's IT centre. Completed in 1885, the oldest part of the building, the former Sheffield Technical School, now the Central Wing, lies in the centre of the building. The extensive Mappin Street frontage includes the main entrance, the John Carr Library and Mappin Hall, and

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3432-491: Is a growing problem, with increasing rates of multiple drug-resistant tuberculosis (MDR-TB). In 2018, one quarter of the world's population was thought to have a latent infection of TB. New infections occur in about 1% of the population each year. In 2022, an estimated 10.6 million people developed active TB, resulting in 1.3 million deaths, making it the second leading cause of death from an infectious disease after COVID-19 . As of 2018, most TB cases occurred in

3588-561: Is a purpose-built multi-disciplinary building that houses lecture theatres, laboratories, workrooms and other facilities for the teaching of engineering. Amongst the more recent additions to the university's estate located on this campus are the Soundhouse (2008; a music practice and studio facility) and the Jessop West building (2009; the first UK project by Berlin architects Sauerbruch Hutton ). The Sir Frederick Mappin Building

3744-671: Is a red brick Edwardian building with ashlar dressings and slate roofs in Perpendicular Revival style. The building was opened by King Edward VII and Queen Alexandra in 1905. Located to the left of Firth Court, the Rotunda is the Registrar and Secretary's Office. Formerly the Edgar Allen Library, it is a neo-Gothic style octagonal chapter house opened 26 April 1909 by Prince and Princess of Wales, which has

3900-449: Is able to reproduce inside the macrophage and will eventually kill the immune cell. The primary site of infection in the lungs, known as the Ghon focus , is generally located in either the upper part of the lower lobe, or the lower part of the upper lobe . Tuberculosis of the lungs may also occur via infection from the blood stream. This is known as a Simon focus and is typically found in

4056-653: Is also rare and is seen almost only in immunodeficient people, although its prevalence may be significantly underestimated. Other known pathogenic mycobacteria include M. leprae , M. avium , and M. kansasii . The latter two species are classified as " nontuberculous mycobacteria " (NTM) or atypical mycobacteria. NTM cause neither TB nor leprosy , but they do cause lung diseases that resemble TB. When people with active pulmonary TB cough, sneeze, speak, sing, or spit, they expel infectious aerosol droplets 0.5 to 5.0 μm in diameter. A single sneeze can release up to 40,000 droplets. Each one of these droplets may transmit

4212-409: Is carried in academic procession as the symbol of authority, which precedes the presiding officer. Tuberculosis Tuberculosis ( TB ), also known colloquially as the " white death ", or historically as consumption , is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria . Tuberculosis generally affects the lungs , but it can also affect other parts of

4368-604: Is connected to the Central Wing by a bridge. In early 2020, the Mappin Building and the Central Wing were refurbished. As a result of the refurbishments, the two buildings are joined by a quadruple-height atrium with curved glass roof. The atrium, called the Engineering Heartspace, houses laboratories, offices and social spaces. Given its name to the campus, St George's Church was the first of three commissioners' churches to be built in Sheffield under

4524-833: Is consistently ranked among the top 10 in Europe and the UK for "Architecture and the Built-Environment" and is one of the longest established architecture schools in the UK, opening in 1908. It was first located in the tower of Firth Court but soon moved to the Sunday School in Shearwood Road and is located on the top 6 floors of the Arts Tower since 1965. The school has courses accredited by the Architects Registration Board (ARB) and

4680-444: Is difficult, as is diagnosing the disease in those who have a weakened immune system. A diagnosis of TB should, however, be considered in those with signs of lung disease or constitutional symptoms lasting longer than two weeks. A chest X-ray and multiple sputum cultures for acid-fast bacilli are typically part of the initial evaluation. Interferon-γ release assays (IGRA) and tuberculin skin tests are of little use in most of

4836-477: Is in green, half-lined with white fur, and edged with two inches of silk of the colour distinctive of the degree or the faculty. Masters wear a black Oxford MA [m1] gown with a hood of green silk which is lined throughout with the faculty colour. The PhD and the MPhil hoods are lined in green. Research doctors have a fine scarlet cloth gown with green silk facings, with bell-shaped sleeves [d2]; higher doctorates wear

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4992-532: Is in three sections, including a taller building clad in red-brick, a shorter fully linked section clad in blue tiles and glass, and a section facing the University Concourse. It was built in the 1950s and re-clad in 2005. The Information Commons (IC) is a library and computing building located within the Western Bank campus on Leavygreave Road. It was opened on 26 September 2007. The building

5148-475: Is located. There is a cluster of buildings located to the north of Broad Lane, opposite St George's campus, collectively called the north campus. Kroto Research Institute, Kroto Innovation Centre , Nanoscience and Technology Building, Graduate Research Centre, George Porter Building and the International College are based on this campus area. To the south of the city on Warminster Road are where

5304-408: Is made up of eight schools and departments. It is also home to three institutes (Humanities Research Institute, Sheffield Institute for Interdisciplinary Biblical Studies, and Digital Humanities Institute) and 16 research centres. The Centre for Research into Freemasonry and Fraternalism of the faculty was the first centre devoted to scholarly research into Freemasonry in a UK university. The centre

5460-585: Is made up of four schools, including the Medical School, Health Sciences School, School of Clinical Dentistry and School of Health and Related Research (ScHARR). The Medical School is the oldest school of the university. It operated independently as the Sheffield School of Medicine until its mergers with Firth College and with Sheffield Technical School. The Medical School is located next to the Royal Hallamshire Hospital , one of

5616-509: Is not widespread, but it is a significant cause of tuberculosis in parts of Africa. M. bovis was once a common cause of tuberculosis, but the introduction of pasteurized milk has almost eliminated this as a public health problem in developed countries. M. canettii is rare and seems to be limited to the Horn of Africa , although a few cases have been seen in African emigrants. M. microti

5772-489: Is often used to screen people at high risk for TB. Those who have been previously immunized with the Bacille Calmette-Guerin vaccine may have a false-positive test result. The test may be falsely negative in those with sarcoidosis , Hodgkin's lymphoma , malnutrition , and most notably, active tuberculosis. Interferon gamma release assays , on a blood sample, are recommended in those who are positive to

5928-791: Is one of the original red brick universities and a founding member of the Russell Group . It is also part of the Worldwide Universities Network , the N8 Group of the eight most research intensive universities in Northern England and the White Rose University Consortium . Sheffield has been ranked in between 66th and 104th best university in the world by QS for the last fifteen years. ARWU ranked Sheffield 9th overall in

6084-583: Is open to University of Sheffield staff and students 24 hours a day, 365 days a year. It houses over 1,300 study spaces, 500 computers, and 100,000 texts. University of Sheffield The University of Sheffield (informally Sheffield University or TUOS ) is a public research university in Sheffield , South Yorkshire , England. Its history traces back to the foundation of Sheffield Medical School in 1828, Firth College in 1879 and Sheffield Technical School in 1884. University College of Sheffield

6240-501: Is performed, MTB either stains very weakly "Gram-positive" or does not retain dye as a result of the high lipid and mycolic acid content of its cell wall. MTB can withstand weak disinfectants and survive in a dry state for weeks. In nature, the bacterium can grow only within the cells of a host organism, but M. tuberculosis can be cultured in the laboratory . Using histological stains on expectorated samples from phlegm (also called sputum), scientists can identify MTB under

6396-423: Is poor as of 2019 . The Centers for Disease Control and Prevention (CDC) stopped recommending yearly testing of health care workers without known exposure in 2019. Tuberculosis prevention and control efforts rely primarily on the vaccination of infants and the detection and appropriate treatment of active cases. The World Health Organization (WHO) has achieved some success with improved treatment regimens, and

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6552-655: Is ranked second in the world and first in Europe for Library and Information Studies in the QS World University Rankings 2020. The Department of Urban Studies and Planning (USP) was founded as the Department of Town and Regional Planning (TRP) in 1965 and is located in the Geography Building in the Western Bank Campus. It was ranked as the top RTPI accredited planning school in the UK by the 2014 Research Excellence Framework (REF) and second for "Building and town and country planning" by

6708-424: Is responsible for the strategic development, legal and regulatory affairs, and performance of university business (finance and property). Council membership comprises a majority of non-executive lay members appointed under the statutes of the university. The chair and pro-chancellor of the council is currently Tony Pedder. The Senate manages the academic side of the university. It is the highest academic authority of

6864-464: Is termed caseous necrosis . If TB bacteria gain entry to the blood stream from an area of damaged tissue, they can spread throughout the body and set up many foci of infection, all appearing as tiny, white tubercles in the tissues. This severe form of TB disease, most common in young children and those with HIV, is called miliary tuberculosis. People with this disseminated TB have a high fatality rate even with treatment (about 30%). In many people,

7020-545: Is the main administrative centre for the University of Sheffield, stands at the heart of the university precinct on Western Bank. It originally housed the Arts, Science and Medicine departments, while it is currently home to the Department for Molecular Biology and Biotechnology and Biomedical Science. The Grade II listed building, named after Mark Firth, was designed by Edward Mitchel Gibbs and built in 1903 to 1905. Firth Court

7176-483: Is the most widely used vaccine worldwide, with more than 90% of all children being vaccinated. The immunity it induces decreases after about ten years. As tuberculosis is uncommon in most of Canada, Western Europe, and the United States, BCG is administered to only those people at high risk. Part of the reasoning against the use of the vaccine is that it makes the tuberculin skin test falsely positive, reducing

7332-704: The Crookesmoor area, and the Faculty of Medicine, Dentistry and Health around the Royal Hallamshire Hospital (although these subjects are taught in the city's extensive teaching hospitals under the Sheffield Teaching Hospitals NHS Foundation Trust , and throughout South Yorkshire and North East Lincolnshire ). It is in this area that the new £12 million Sheffield Institute for Translational Neuroscience (SITraN), opened by Queen Elizabeth II in November 2010,

7488-846: The Guardian University Rankings 2021. The university has an international faculty called CITY College in Thessaloniki , the second largest city of Greece, which is the only faculty operating outside the UK. The faculty was established in 1989 in order to bridge the UK with the Southeast and Eastern Europe. It is a private legal entity operating as CITY College according to the local law in Greece. The International Faculty consists of four departments, namely Business Administration and Economics, Psychology, Computer Science and English Studies. These departments are housed in

7644-678: The Sheffield Students' Union building, the Octagon Centre, Graves Building, Hicks Building and the Information Commons. The nearest motorway is the A57 . The Western Bank Campus refers to the campus area located to the west of the Sheffield Inner Ring Road . It is so called because this campus has expanded from Firth Court on Western Bank. To the east of the ring road is the St George's campus area of

7800-452: The citric acid cycle (also known as the Krebs cycle) in 1937, which earned him a Nobel Prize for Medicine and Physiology for 1953. In 1938, the university opened the Department of Biochemistry (renamed since the 1990s as the Department of Molecular Biology and Biotechnology) and Krebs became its first Head. Krebs Institute, a research centre for mechanistic biology, was founded in 1988 within

7956-458: The lymphatic system (in scrofula of the neck), the genitourinary system (in urogenital tuberculosis ), and the bones and joints (in Pott disease of the spine), among others. A potentially more serious, widespread form of TB is called "disseminated tuberculosis"; it is also known as miliary tuberculosis . Miliary TB currently makes up about 10% of extrapulmonary cases. The main cause of TB

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8112-420: The tuberculin skin test (TST) or blood tests. Prevention of TB involves screening those at high risk, early detection and treatment of cases, and vaccination with the bacillus Calmette-Guérin (BCG) vaccine. Those at high risk include household, workplace, and social contacts of people with active TB. Treatment requires the use of multiple antibiotics over a long period of time. Antibiotic resistance

8268-577: The 1920s from two ends on Western Bank and on the St George's site. The number of full-time students was stabilized at about 750 between the two world wars. In 1943, the University Grants Committee announced that universities in the UK should look forward to expansion in the years after the Second World War . Sheffield predicted a 50% increase in student population but the university was unprepared for such growth. There

8424-621: The 1950s and 1960s when it began to expand rapidly. Many new buildings (including the Main Library and the Arts Tower ) were built and older houses were brought into academic use. Student numbers increased to their present levels of just under 26,000. At the same time in the 1950s, the university was expanding at other sites, including the St Georges area. From the 1960s, many more buildings have been constructed or extended, including

8580-401: The 19th century. In 2008 it was taken over by the School of Law. The Dainton Building, houses the Department of Chemistry and Faculty of Sciences, is named after Sheffield academic chemist and university chancellor Frederick Sydney Dainton . The East Wing of Dainton Building was renamed Richard Roberts Building after Nobel Laureate and University graduate Richard Roberts . The Dainton Building

8736-743: The Church Building Act 1818. It was built in the Perpendicular style. The church closed in 1981 and was acquired by the university. It was converted for use as a lecture theatre in 1994, while the upstairs has been converted for use as student accommodation. Further west lies Weston Park, the Weston Park Museum , the Harold Cantor Gallery , university's sports facilities Goodwin Sports Centre in

8892-852: The Court included all the members of Parliament (MPs) of Sheffield, the Bishops of Sheffield and Hallam, and the chief constable of South Yorkshire Police. It also included representatives of professional bodies such as the Arts Council , Royal Society and the General Medical Council . The Court met annually to receive reports from the council, the Senate and the Students' Union. It served many official functions including chancellor election. The university's annual income for 2019–20

9048-410: The Department of Biochemistry. George Porter joined the university as Professor of Physical Chemistry in 1955 and he further developed his later Nobel Prize-winning work flash photolysis at Sheffield. Porter was appointed Firth Professor of Chemistry and became Head of the Department of Chemistry in 1963. In the 21st century, the university opened many more major buildings in the area immediately to

9204-627: The Engineering campus, St George's campus is centred on Mappin Street, the location of the Faculty of Engineering (partly housed in the Grade II-listed Mappin Building ) and the Department of Journalism Studies, Department of Economics and Department of Computer Science . The university also maintains the Turner Museum of Glass in this area. As part of the 2000s development plan, the university has converted

9360-405: The Faculty of Social Sciences was pale green. The university mace is an ornament of governance of the University of Sheffield. It is silver-gilt and carries the coats of arms of both the university and the city of Sheffield, and the White Rose of York . A figure of Minerva holding a wreath and palm branch on a heraldic crown adorns the top of the mace. Used for the first time in 1909, the mace

9516-416: The L. Sofou Building and the Strategakis Building, two buildings in close proximity in Thessaloniki city centre. The faculty also operates the South East European Research Centre (SEERC), a multidisciplinary research centre established in 2003. There are several bodies which govern the university, including the council, the Senate and the faculties. The council is the governing body of the university, which

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9672-643: The Mantoux test. These are not affected by immunization or most environmental mycobacteria , so they generate fewer false-positive results. However, they are affected by M. szulgai , M. marinum , and M. kansasii . IGRAs may increase sensitivity when used in addition to the skin test, but may be less sensitive than the skin test when used alone. The US Preventive Services Task Force (USPSTF) has recommended screening people who are at high risk for latent tuberculosis with either tuberculin skin tests or interferon-gamma release assays . While some have recommend testing health care workers, evidence of benefit for this

9828-478: The Royal Institute of British Architects (RIBA), and has an active student society (SUAS). In the Research Excellence Framework (REF) 2014, Sheffield School of Architecture ranked 4th in the UK. Established in 1986, the Management School is a triple-accredited (AMBA, AACSB and EQUIS) business school. In 2013 the school moved into newly refurbished facilities close to the University of Sheffield campus and Broomhill. It now has dedicated learning and teaching space,

9984-410: The Sheffield and North Trent College of Nursing and Midwifery, forming a new School of Nursing and Midwifery. The St George's Hospital was extended and a new building at the Northern General Hospital has been constructed, which greatly increased the size of the medical faculty. Hans Adolf Krebs was appointed as lecturer in pharmacology in 1935. At Sheffield Krebs and his postgraduate student discovered

10140-433: The Sheffield's teaching hospitals, and the school is associated with Sheffield Children's Hospital , Northern General Hospital , Weston Park Hospital and Charles Clifford Dental Hospital . It is one of 32 bodies entitled to award medical degrees in the United Kingdom by the General Medical Council (GMC), the body responsible for registering doctors to practise medicine as well as regulating medical education and training in

10296-417: The UK and THE ranked the university 22nd in Europe for teaching excellence. According to the latest Research Excellence Framework 2021, Sheffield is ranked 11th in the UK for research power calculated by multiplying the institution's GPA by the total number of full-time equivalent staff submitted. There are six Nobel laureates affiliated with Sheffield, as either the alumni or former long-term staff of

10452-530: The UK. Biology has been taught in Sheffield since 1884 in Firth College. Appointed the first Professor of Biology in 1888, Alfred Denny was the only biologist in the Department of Biology at the college who taught zoology and botany to science and medical students. In 1896, a second biologist, botanist Bertram H. Bentley, joined the college. Soon after the university was founded, in 1908, two separate departments were established: Zoology (head by Denny) and Botany (head by Bentley). The departments were not merged until

10608-410: The Union of Students and St George's Library. The campus master plan proposed in the 1940s was completed by the 1970s, and the university required a new development plan. The 1980s saw the opening of many new buildings and centres, such as the multi-purpose Octagon Centre and the Sir Henry Stephenson Building. The university's teaching hospital, Northern General Hospital , was also extended. In 1987

10764-469: The United Kingdom. The Faculty of Science comprises seven classical science departments: Animal and Plant Sciences, Biomedical Science, Chemistry, Mathematics and Statistics, Molecular Biology and Biotechnology, Physics and Astronomy, and Psychology. All of the university's six Nobel Laureates have been affiliated with this faculty. The Department of Animal and Plant Sciences is one of the largest departments dedicated for whole-organism biology studies in

10920-461: The United States test positive via the tuberculin test. Tuberculosis has been present in humans since ancient times . Tuberculosis has existed since antiquity . The oldest unambiguously detected M. tuberculosis gives evidence of the disease in the remains of bison in Wyoming dated to around 17,000 years ago. However, whether tuberculosis originated in bovines, then transferred to humans, or whether both bovine and human tuberculosis diverged from

11076-449: The University Executive Board, whose members are: president and vice-chancellor (or simply vice-chancellor), provost and deputy vice chancellor, chief financial officer, executive director of corporate services, executive director of academic services, five faculty vice-presidents, three cross-cutting vice-presidents (education, innovation and research), and university secretary. The board provides leadership and management, as well as advises

11232-617: The WHO regions of South-East Asia (44%), Africa (24%), and the Western Pacific (18%), with more than 50% of cases being diagnosed in seven countries: India (27%), China (9%), Indonesia (8%), the Philippines (6%), Pakistan (6%), Nigeria (4%), and Bangladesh (4%). By 2021, the number of new cases each year was decreasing by around 2% annually. About 80% of people in many Asian and African countries test positive, while 5–10% of people in

11388-622: The Western Bank Building, Firth Court is a red brick Edwardian building in Perpendicular Revival style, and is connected to the 1971 modernist Alfred Denny Building . The nearby Arts Tower is also an example of postwar modernist building in the International Style . The Diamond, a contemporary architecture designed by Twelve Architects, is situated next to the Victorian Jessop Building on

11544-578: The Winter Street Hospital for Infectious Diseases, it became a dedicated tuberculosis hospital in 1912, and was later the St George's Hospital for geriatric patients, which closed in 1990. After refurbishment it became the School of Nursing for the University of Sheffield in 1997. It was named Bartolomé House in 1998 after Dr Mariano Martin de Bartolomé, who was President of the Sheffield Medical School for 22 years in

11700-688: The active disease. Use of certain medications, such as corticosteroids and infliximab (an anti-αTNF monoclonal antibody), is another important risk factor, especially in the developed world . Other risk factors include: alcoholism , diabetes mellitus (3-fold increased risk), silicosis (30-fold increased risk), tobacco smoking (2-fold increased risk), indoor air pollution , malnutrition, young age, recently acquired TB infection, recreational drug use, severe kidney disease, low body weight, organ transplant, head and neck cancer, and genetic susceptibility (the overall importance of genetic risk factors remains undefined ). Tobacco smoking increases

11856-421: The aim of providing education in the city which lacked any tertiary institutions. During the period, the steel industry in Sheffield was prospering and the city's population was doubled to around 240,000 from the 1840s. In 1871, the university extension scheme arrived in Sheffield, and a group of lecturers from the universities of Oxford and Cambridge travelled to the city giving lectures and educating people about

12012-458: The arrival of streptomycin and other antibiotics, although the disease remained a significant threat. In 1946, the development of the antibiotic streptomycin made effective treatment and cure of TB a reality. Prior to the introduction of this medication, the only treatment was surgical intervention, including the " pneumothorax technique", which involved collapsing an infected lung to "rest" it and to allow tuberculous lesions to heal. Because of

12168-423: The bacterium is enveloped by the macrophage and stored temporarily in a membrane-bound vesicle called a phagosome. The phagosome then combines with a lysosome to create a phagolysosome. In the phagolysosome, the cell attempts to use reactive oxygen species and acid to kill the bacterium. However, M. tuberculosis has a thick, waxy mycolic acid capsule that protects it from these toxic substances. M. tuberculosis

12324-462: The benefits of tertiary education. Steel manufacturer and former mayor of Sheffield Mark Firth and clergyman Samuel Earnshaw therefore organised courses in English literature and political economy. The courses became popular so Firth decided to donate £20,000 and purchase a site in the city centre (now Leopold Street and West Street) in 1877 to build a new institution for the classes. Firth College

12480-425: The body. Most infections show no symptoms, in which case it is known as latent tuberculosis . Around 10% of latent infections progress to active disease that, if left untreated, kill about half of those affected. Typical symptoms of active TB are chronic cough with blood-containing mucus , fever , night sweats , and weight loss . Infection of other organs can cause a wide range of symptoms. Tuberculosis

12636-569: The campus. In 2005, the South Yorkshire Strategic Health Authority announced that it would split the training between Sheffield and Sheffield Hallam University – however, the university decided to pull out of providing preregistration nursing and midwifery training due to "costs and operational difficulties". On 28 September 2015, a new six-storey building, the Diamond , was opened. In February 2016,

12792-425: The cattle and human tuberculosis diseases were similar, which delayed the recognition of infected milk as a source of infection. During the first half of the 1900s, the risk of transmission from this source was dramatically reduced after the application of the pasteurization process. Koch announced a glycerine extract of the tubercle bacilli as a "remedy" for tuberculosis in 1890, calling it "tuberculin". Although it

12948-485: The cause of pulmonary tuberculosis. J. L. Schönlein first published the name "tuberculosis" (German: Tuberkulose ) in 1832. Between 1838 and 1845, John Croghan, the owner of Mammoth Cave in Kentucky from 1839 onwards, brought a number of people with tuberculosis into the cave in the hope of curing the disease with the constant temperature and purity of the cave air; each died within a year. Hermann Brehmer opened

13104-451: The coat of arms, which remains the official heraldic symbol of the university. The university's fonts are TUOS Stephenson ( serif ) and TUOS Blake ( sans-serif ). Both TUOS Stephenson and TUOS Blake are modified versions of a typeface designed by Sheffield company Stephenson & Blake Co. The two fonts are the copyright property of the University of Sheffield and are restricted only to university users. The university brand (encompassing

13260-711: The declaration of a global health emergency by the World Health Organization (WHO) in 1993. There is a popular misconception that tuberculosis is purely a disease of the lungs that manifests as coughing . Tuberculosis may infect many organs, even though it most commonly occurs in the lungs (known as pulmonary tuberculosis). Extrapulmonary TB occurs when tuberculosis develops outside of the lungs, although extrapulmonary TB may coexist with pulmonary TB. General signs and symptoms include fever, chills , night sweats, loss of appetite , weight loss, and fatigue . Significant nail clubbing may also occur. If

13416-493: The department, which was met with international outcry. The precursor to the Faculty of Engineering is the Sheffield Technical School established in the 1880s, which offered part-time and evening class programme to adults working in the steel industry. During 1917, departments of Electronic and Electrical Engineering, Civil and Structural Engineering and Mechanical Engineering were founded in response to

13572-640: The developing world. IGRA have similar limitations in those with HIV. A definitive diagnosis of TB is made by identifying M. tuberculosis in a clinical sample (e.g., sputum, pus , or a tissue biopsy ). However, the difficult culture process for this slow-growing organism can take two to six weeks for blood or sputum culture. Thus, treatment is often begun before cultures are confirmed. Nucleic acid amplification tests and adenosine deaminase testing may allow rapid diagnosis of TB. Blood tests to detect antibodies are not specific or sensitive , so they are not recommended. The Mantoux tuberculin skin test

13728-610: The disease became common among the urban poor. In 1815, one in four deaths in England was due to "consumption". By 1918, TB still caused one in six deaths in France. After TB was determined to be contagious, in the 1880s, it was put on a notifiable-disease list in Britain. Campaigns started to stop people from spitting in public places, and the infected poor were "encouraged" to enter sanatoria that resembled prisons. The sanatoria for

13884-620: The disease, since the infectious dose of tuberculosis is very small (the inhalation of fewer than 10 bacteria may cause an infection). People with prolonged, frequent, or close contact with people with TB are at particularly high risk of becoming infected, with an estimated 22% infection rate. A person with active but untreated tuberculosis may infect 10–15 (or more) other people per year. Transmission should occur from only people with active TB – those with latent infection are not thought to be contagious. The probability of transmission from one person to another depends upon several factors, including

14040-407: The early 20th century, the university taught non-degree courses that covered non-conventional, occupation-focused subjects such as cow-keeping, railway economics, mining and razor-grinding. The university has currently five faculties comprising 50 departments and 82 research centres and institutes, plus an international faculty. The current faculty structure is: The Faculty of Arts and Humanities

14196-575: The east and west of Upper Hanover Street , such as the Jessop Building, the Soundhouse, Jessop West and the Information Commons . The Arts Tower building, the Students' Union and University House buildings, the Sheffield Bioincubator and University Health Centre were also refurbished. A new campus, North Campus, was opened. In 2003, a development framework was produced by Turnberry Consulting, with proposals aimed to densify

14352-459: The east of the main campus lies St George's campus, named after St George's Church (now a lecture theatre and postgraduate residence). The campus is the historical location of the Sheffield Technical School. It is bounded by Upper Hanover Street to the west, Broad Lane to the north, Rockingham Street to the east, and West Street to the south, and is part of St George's Quarter , one of the seven official Sheffield city centre quarters. Also known as

14508-463: The emergence of multidrug-resistant tuberculosis (MDR-TB), surgery has been re-introduced for certain cases of TB infections. It involves the removal of infected chest cavities ("bullae") in the lungs to reduce the number of bacteria and to increase exposure of the remaining bacteria to antibiotics in the bloodstream. Hopes of eliminating TB ended with the rise of drug-resistant strains in the 1980s. The subsequent resurgence of tuberculosis resulted in

14664-563: The establishment of the Department of Animal and Plant Sciences in 1988, as part of a major rationalisation at the university. David H. Lewis, who was Head of Botany, was the first Head of Animal and Plant Sciences. The department was awarded a maximum score of 24 points in the QAA Teaching Quality Assessment in 1999, and top five for biological sciences research in the REF 2014. The Sheffield School of Architecture

14820-587: The faculty colour. The faculty and degree colours are: Arts and Humanities—crushed strawberry; Music (only for BMus, MMus, and DMus degrees)—cream brocade; Engineering—purple; Medicine and Surgery—red; Dental Surgery—pale rose pink; Health— cerise ; Science— apricot ; Social Sciences— lemon yellow ; International Faculty—Saxon blue; Board of Extra Faculty Provision—pale blue. Some schools at Sheffield had previously their own colours but are no longer used. They were: Metallurgy— steel grey ; Education— pearl ; Architecture— old gold ; Law— olive green . The old colour of

14976-552: The first TB sanatorium in 1859 in Görbersdorf (now Sokołowsko ) in Silesia . In 1865, Jean Antoine Villemin demonstrated that tuberculosis could be transmitted, via inoculation, from humans to animals and among animals. (Villemin's findings were confirmed in 1867 and 1868 by John Burdon-Sanderson . ) Robert Koch identified and described the bacillus causing tuberculosis, M. tuberculosis , on 24 March 1882. In 1905, he

15132-569: The first genuine success in immunization against tuberculosis in 1906, using attenuated bovine-strain tuberculosis. It was called bacille Calmette–Guérin (BCG). The BCG vaccine was first used on humans in 1921 in France, but achieved widespread acceptance in the US, Great Britain, and Germany only after World War II. By the 1950s mortality in Europe had decreased about 90%. Improvements in sanitation, vaccination, and other public-health measures began significantly reducing rates of tuberculosis even before

15288-519: The first hospital in the city. Because of the apprenticeship-type training, the medical education at that time was largely unstructured. Regarded as the father of Sheffield's medical education, surgeon apothecary Hall Overend began to train medical students in 1811. His school of anatomy and medicine was externally recognised in 1828, and he conducted and taught human dissection in an anatomy museum at his home in Church Street . Overend, however,

15444-459: The former site of Jessop's Edwardian wing. A total of 36 university estate are listed . Of these, the Arts Tower and Western Bank Library are Grade II* listed buildings. Firth Court, Mappin Building, St George's Church, Jessop Building and the Drama Studio are listed Grade II. The centre of the university's presence lies one mile to the west of Sheffield city centre, where there is a mile-long collection of buildings belonging almost entirely to

15600-412: The foundation of the university college, on 18 May 1903, the resolution to apply for a royal charter was passed. The university college started to develop its estate soon after: Western House by Weston Park on Western Bank was bought and demolished in 1903 for building a new university property. A building with a traditional collegiate quadrangle (later known as Western Bank building and now Firth Court)

15756-496: The fourth member of the federal Victoria University . The new university was proposed to be named "Victoria University of Yorkshire" by Leeds but was rejected by the Privy Council. The Victoria University, however, began to split up as independent universities before this could happen, when Liverpool gained a charter of its own in 1903. Rather than joining a Yorkshire university with Leeds, the University College of Sheffield

15912-431: The host's immune system. Macrophages and dendritic cells in the granulomas are unable to present antigen to lymphocytes; thus the immune response is suppressed. Bacteria inside the granuloma can become dormant, resulting in latent infection. Another feature of the granulomas is the development of abnormal cell death ( necrosis ) in the center of tubercles . To the naked eye, this has the texture of soft, white cheese and

16068-400: The infected macrophages. When other macrophages attack the infected macrophage, they fuse together to form a giant multinucleated cell in the alveolar lumen. The granuloma may prevent dissemination of the mycobacteria and provide a local environment for interaction of cells of the immune system. However, more recent evidence suggests that the bacteria use the granulomas to avoid destruction by

16224-439: The infection spreads outside the lungs, causing other kinds of TB. These are collectively denoted as extrapulmonary tuberculosis. Extrapulmonary TB occurs more commonly in people with a weakened immune system and young children. In those with HIV, this occurs in more than 50% of cases. Notable extrapulmonary infection sites include the pleura (in tuberculous pleurisy), the central nervous system (in tuberculous meningitis ),

16380-613: The infection waxes and wanes. Tissue destruction and necrosis are often balanced by healing and fibrosis . Affected tissue is replaced by scarring and cavities filled with caseous necrotic material. During active disease, some of these cavities are joined to the air passages ( bronchi ) and this material can be coughed up. It contains living bacteria and thus can spread the infection. Treatment with appropriate antibiotics kills bacteria and allows healing to take place. Upon cure, affected areas are eventually replaced by scar tissue. Diagnosing active tuberculosis based only on signs and symptoms

16536-491: The life from the other family members. Although Richard Morton established the pulmonary form associated with tubercles as a pathology in 1689, due to the variety of its symptoms, TB was not identified as a single disease until the 1820s. Benjamin Marten conjectured in 1720 that consumptions were caused by microbes which were spread by people living close to each other. In 1819, René Laennec claimed that tubercles were

16692-581: The listed Victorian Jessop Hospital for Women into the new home of the Department of Music in 2009. The formerly Grade II-listed Edwardian wing of the Jessop Hospital was demolished after Sheffield City Council's planning committee voted for approval. The building was replaced by a new £81 million building for the Faculty of Engineering which opened in September 2015, named the Diamond . It

16848-538: The mezzanine level links the tower to the Western Bank Library. The two buildings, both designed by Gollins Melvin Ward , are intended to be viewed together. The library was designed as a result of a national competition. It was opened by poet T. S. Eliot in 1959. Formerly known as the University Library, the Western Bank Library was the main library of the University of Sheffield until the Information Commons

17004-537: The middle and upper classes offered excellent care and constant medical attention. What later became known as the Alexandra Hospital for Children with Hip Disease (tuberculous arthritis) was opened in London in 1867. Whatever the benefits of the "fresh air" and labor in the sanatoria, even under the best conditions, 50% of those who entered died within five years ( c. 1916). Robert Koch did not believe

17160-471: The needs of the First World War. The departments provided training courses for injured and incapacitated soldiers, and manufactured inspection gauges and munition shells. The Faculty of Engineering has now over 6,700 students and 1,000 staff. Over 90% of the research from the department was rated as 4* (world-leading) or 3* (internationally excellent). The Faculty of Medicine, Dentistry and Health

17316-596: The newly infected person becomes infectious enough to transmit the disease to others. A number of factors make individuals more susceptible to TB infection and/or disease. The most important risk factor globally for developing active TB is concurrent HIV infection; 13% of those with TB are also infected with HIV. This is a particular problem in sub-Saharan Africa , where HIV infection rates are high. Of those without HIV infection who are infected with tuberculosis, about 5–10% develop active disease during their lifetimes; in contrast, 30% of those co-infected with HIV develop

17472-599: The number of infectious droplets expelled by the carrier, the effectiveness of ventilation, the duration of exposure, the virulence of the M. tuberculosis strain , the level of immunity in the uninfected person, and others. The cascade of person-to-person spread can be circumvented by segregating those with active ("overt") TB and putting them on anti-TB drug regimens. After about two weeks of effective treatment, subjects with nonresistant active infections generally do not remain contagious to others. If someone does become infected, it typically takes three to four weeks before

17628-463: The opening of the Sheffield Technical School in 1884 to teach applied science, the only major faculty the existing colleges did not cover. The Sheffield Technical School was created by collecting funds within Firth College because of local concern about the need for technical training, particularly steelmaking in Sheffield. Former mayor of Sheffield Sir Frederick Mappin started to fundraise for

17784-409: The original Henderson's factory . The University of Sheffield is not a campus university , though most of its 430 buildings are located in fairly close proximity to each other. It is divided geographically by the Sheffield Inner Ring Road . The Upper Hanover Street section of the ring road splits university buildings into the Western Bank and the St George's campus areas. Instead of growing from

17940-621: The quadrangle was converted into an air raid shelter. Alfred Denny Building, a red brick building named after the first Professor of Zoology at the department, is connected to Firth Court via the Addison Building. The building houses the Biomedical Science, Animal and Plant Science Departments including its associated museum, Disability and Dyslexia Support Service, and the Perak Laboratories. The Arts Tower

18096-435: The risk of developing active TB increases to nearly 10% a year. If effective treatment is not given, the death rate for active TB cases is up to 66%. TB infection begins when the mycobacteria reach the alveolar air sacs of the lungs, where they invade and replicate within endosomes of alveolar macrophages . Macrophages identify the bacterium as foreign and attempt to eliminate it by phagocytosis . During this process,

18252-414: The risk of infections (in addition to increasing the risk of active disease and death). Additional factors increasing infection susceptibility include young age. About 90% of those infected with M. tuberculosis have asymptomatic , latent TB infections (sometimes called LTBI), with only a 10% lifetime chance that the latent infection will progress to overt, active tuberculous disease. In those with HIV,

18408-515: The robe with full sleeves that are lined scarlet silk and the lining held up at the elbow level with a scarlet cord and button [d1]. The hood is of the Cambridge shape [f1] and is made of red ottoman silk. In 1993, the postgraduate diplomate hood is entered in the Calendar of the University of Sheffield. It is a blend of Bachelors' and Masters' hoods, with a hood of green silk and a neckband of

18564-419: The school and £10,240 was raised. A grant was secured in 1883 to fund a professor of Metallurgy and Mechanical Engineering. Many of the steel-making firms in Sheffield contributed to funding the Technical School, and research from the school in turn helped develop new processes and products for the companies. The Technical School was originally founded as a new technical department in Firth College, and in 1886,

18720-521: The school moved to St George's Square (later renamed Charlotte Street and now Mappin Street) on the site of the old Grammar School . William Ripper was appointed as Head of Mechanical Engineering at Firth College from 1889, then Principal of Sheffield Technical School. Sheffield was at that time the only large city in England without a university. William Mitchinson Hicks , who was Principal of Firth College from 1892 to 1897, had an ambition to establish

18876-574: The southern area of the campus are the Sheffield Students' Union , the Octagon Centre , Graves Building and Hicks Building . A concourse under the A57 flyover connects Alfred Denny Building on the north side and Students' Union on the south. Until the completion of three pedestrian crossings on Western Bank in 2017, the concourse underpass was the only link that allowed students to easily move between buildings in this cluster. The Information Commons,

19032-549: The spines of Egyptian mummies dating from 3000 to 2400 BC. Genetic studies suggest the presence of TB in the Americas from about AD 100. Before the Industrial Revolution , folklore often associated tuberculosis with vampires . When one member of a family died from the disease, the other infected members would lose their health slowly. People believed this was caused by the original person with TB draining

19188-475: The sports pitches at Norton Sports Park located. The university also operates Advanced Manufacturing Research Centres (AMRCs) on the border of Sheffield, in Rotherham and Lancashire. The Conference Centre and Teaching Hall at Philadelphia Campus of St. Thomas' Church are used as exam venues by the university. The old Firth College building was built in 1879 at the corner of Leopold Street and West Street. It

19344-465: The test's usefulness as a screening tool. Several vaccines are being developed. Intradermal MVA85A vaccine in addition to BCG injection is not effective in preventing tuberculosis. Public health campaigns which have focused on overcrowding, public spitting and regular sanitation (including hand washing) during the 1800s helped to either interrupt or slow spread which when combined with contact tracing, isolation and treatment helped to dramatically curb

19500-531: The time had 71 members of staff. By then, the first Hall of Residence (Stephenson Hall) and library (Edgar Allen library) had been established. The number of students increased to a short-lived peak of 1,000 in 1919 when returning ex-servicemen were admitted to the university. During the First World War , some of the academic subjects and courses were replaced by teaching of munitions making and medical appliances production. The university has expanded since

19656-565: The top of the lung. This hematogenous transmission can also spread infection to more distant sites, such as peripheral lymph nodes, the kidneys, the brain, and the bones. All parts of the body can be affected by the disease, though for unknown reasons it rarely affects the heart , skeletal muscles , pancreas , or thyroid . Tuberculosis is classified as one of the granulomatous inflammatory diseases. Macrophages , epithelioid cells , T lymphocytes , B lymphocytes , and fibroblasts aggregate to form granulomas, with lymphocytes surrounding

19812-467: The transmission of both tuberculosis and other airborne diseases which led to the elimination of tuberculosis as a major public health issue in most developed economies. Other risk factors which worsened TB spread such as malnutrition were also ameliorated, but since the emergence of HIV a new population of immunocompromised individuals was available for TB to infect. During the HIV/AIDS epidemic in

19968-745: The university began to collaborate with its once would-be partners of the Victoria University by co-founding the Northern Consortium ; a coalition for the education and recruitment of international students. The university continued to expand in the 1990s. New premises were opened for School of the Clinical Dentistry, the Division of Education, and the Management School. In 1995, the university took over

20124-652: The university started to work with Sheffield City Council to transform public spaces around the campus. The £8 million project includes building and improving pedestrianisation, crossings, cycle routes, as well as greening the campus. The university intended to expand the Advanced Manufacturing Research Centre and provision for apprenticeships; however, while the Sheffield City Region Local Enterprise Partnership recommended that

20280-513: The university, and is also responsible for the regulation of research work and students' discipline. The Senate is chaired by the vice-chancellor, with its membership drawn mainly from the university's academic staff. The five faculties regulates departmental teaching, research, examination, and also admission. They are responsible for making recommendations to the Senate on the award of degrees, fellowships, and academic staff appointments and promotions. The university central committees also include

20436-469: The university. They are contributors to the development of penicillin, the discovery of the citric acid cycle, the investigation of high-speed chemical reactions, the discovery of introns in eukaryotic DNA, the discovery of fullerene, and the development of molecular machines. Alumni also include several heads of state , Home Secretaries , Court of Appeal judges , Booker Prize winners, astronauts and Olympic gold medallists. The University of Sheffield

20592-409: The university. The Western Bank Campus is divided by Western Bank ( A57 ) into the northern and the southern areas. The University Concourse under the A57 flyover connects Alfred Denny Building on the north of Western Bank and Students' Union on the south. Three pedestrian crossings (at Firth Court, at the Arts Tower and at Favell Road) allows easily moving between buildings in this cluster. Firth Court

20748-453: The university. This main campus area is bounded by Upper Hanover Street to the east, Glossop Road to the south, Clarkson Street to the west, and Bolsover Street to the north. Western Bank ( A57 ) runs through the campus. The area to the north of Western Bank includes Firth Court , Alfred Denny Building , Western Bank Library and Arts Tower , Geography and Planning building, Bartolomé House , and Dainton and Richard Roberts Buildings. Within

20904-491: The vice-chancellor on operational matters. the vice-chancellor is the chief executive and accountable officer of the university. The current vice-chancellor is Koen Lamberts , and the provost and deputy vice chancellor is Gill Valentine . The Court of the university is no longer a university committee. The Court was a large body which fosters relations between the university and the community, and included lay members, many of whom are university alumni. Ex-officio members of

21060-447: The visual identity) is led by its motto Rerum cognoscere causas and centred on the theme of "discovery". The theme has been applied across print, screen and other areas such as signage, vehicle livery and merchandising. As at most universities, Sheffield graduands wear academic dress appropriate to the degree they are to be received when graduating. Bachelors wear a black Oxford BA [b1] gown (see Groves classification system ). The hood

21216-428: The words Disce Doce between in fess two sheaves of eight arrows interlaced saltireways and banded argent, in chief an open crown or, and in base a rose also argent barbed and seeded proper. The current university's logo, consists of a redrawn version of the coat of arms and the name of the institution, is introduced in 2005, the centenary year of the university. However, the logo should not supersede and be confused with

21372-531: The £10 million funding bid should be approved, the university withdrew the bid in November 2018. The University Concourse was refurbished in 2019 to replace the 50-year-old paving and walls. Major development projects in the 2020s include constructions of a new Information School building (Northumberland Road Building), Social Sciences Building, Royce Discovery Centre, energy centre (the Transformer), Translational Energy Research Centre, and redevelopment of

21528-526: Was awarded the Nobel Prize in Physiology or Medicine for this discovery. In Europe, rates of tuberculosis began to rise in the early 1600s to a peak level in the 1800s, when it caused nearly 25% of all deaths. In the 18th and 19th century, tuberculosis had become epidemic in Europe , showing a seasonal pattern. Tuberculosis caused widespread public concern in the 19th and early 20th centuries as

21684-450: Was built in 1963, which is one of the first buildings with glass curtain walls in the world. The building complex was redesigned and refurbished by HLM architects between 2012 and 2013, and currently known, together with adjacent Link buildings, as the Students' Union Building. The Octagon Centre is a multi-purpose conference centre and music venue situated at the Western Bank campus. The Octagon Centre comprises an eight-sided auditorium with

21840-440: Was closed in 2010, ten years after its establishment, due to its failure to capture substantial grants to support the centre's activities. In May 2021, archaeology staff at the university have been told their jobs could be at risk after a review. A petition to save the department has gathered more than 35,000 signatures but the university said no decisions had yet been taken, but later changed to announcing they intended to dissolve

21996-511: Was designed by Thomas James Flockton and Edward Robert Robson with the front facing West Street. Firth College moved out of the building following the establishment of the university. The building later housed the Sheffield Central Technical School and is currently home to Education Committee offices of Sheffield City Council. Situated on 7 Leopold Street opposite Firth College, the old Medical School building

22152-438: Was designed by John Dodsley Webster and completed in 1888. The school moved to Firth Court in 1905 and the building is now used as offices. The Manvers campus, at Wath-on-Dearne between Rotherham and Barnsley , was where the majority of nursing was taught. A three-storey building, Humphry Davy House (named after chemist Humphry Davy ), was built in 1998 on Golden Smithies Lane opposite to Dearne Valley College . The building

22308-410: Was driven by civic pride to pursue independent university status, to bring higher education, give support to industries and serve as a centre for disease study. Hicks also advocated the independent degree awarding power would attract talented staff. The University College of Sheffield's charter was sealed on 31 May 1905 and became the University of Sheffield. On 12 July 1905, Firth Court on Western Bank

22464-515: Was established in April 2007. The Grade II*-listed library is home to 25,000 rare books and 150 special collections. Bartolomé House is a set of grade II-listed buildings on Winter Street, which house the School of Law at the University of Sheffield. It was designed by S. L. Swann in Gothic Revival style in red brick with ashlar dressings and slate roofs. Originally constructed in 1881 as

22620-511: Was founded during Firth's late year in 1879 and developed out of the Extension Movement scheme to teach arts and pure science subjects. The college saved the medical school, which had an insecure early history, from collapse and took over the teaching of all background subjects to medical students. In 1888 the medical school was relocated, opposite Firth College, to a new building on Leopold Street. Firth College also helped to fund

22776-458: Was home to the School of Nursing and Midwifery, which was established in 1995 after the merger of the university with Sheffield and North Trent College of Nursing and Midwifery. In 2004, the university disagreed with the South Yorkshire Strategic Health Authority's decision to take away part of its nursing and midwifery training contract, and declined the offer due to financial and operational constraints. The last intake of midwifery studies students

22932-657: Was in July 2006, and the campus was closed one year later. The building was sold in 2018 and to be converted for residential lettings. From 2022 to 2023, students protested against the university working with and accepting payment for various activities from companies including Rolls Royce, BAE Systems, and Boeing who are involved in the arms manufacturing industry. Sheffield had four faculties in 1905, which were Arts, Pure Science, Medicine and Applied Science. The Faculty of Applied Science later split into Engineering and Metallurgy in 1919. As well as educating full-time students, in

23088-478: Was not effective, it was later successfully adapted as a screening test for the presence of pre-symptomatic tuberculosis. World Tuberculosis Day is marked on 24 March each year, the anniversary of Koch's original scientific announcement. When the Medical Research Council formed in Britain in 1913, it initially focused on tuberculosis research. Albert Calmette and Camille Guérin achieved

23244-523: Was not officially registered as a lecturer with the Society of Apothecaries , a recognised body for medical education. Physicians and surgeons of the General Infirmary suggested that a school associated with the hospital would be highly eligible for recognition by the society. As a result, in 1828, a public meeting was called by physician Sir Arnold Knight, and supported by Overend, to establish

23400-473: Was opened by King Edward VII and Queen Alexandra . St George's Square remained the centre of departments of Applied Science, and the departments of Arts, Medicine and Science moved to Western Bank. Sheffield is one of the six pre-World War One red brick universities , the civic universities founded in the major industrial cities of England. In 1905, when the university first opened, there were 363 students and 114 of them were enrolled full-time. Sheffield at

23556-626: Was opened by the Duke of Scarborough in the 1950s. The East Wing (Richard Roberts Building) was built in 1961, followed by the West Wing (Haworth Wing) in 1964, and the North Wing (Beaumont Wing) in 1968. The Geography and Planning building is located next to Weston Park opposite Bartolomé House. It was designed as a cluster of hexagons in 1960, and is home to the departments of Geography, and Urban Studies and Planning. The original University House

23712-478: Was originally formed by the merger of three local institutions: the Sheffield School of Medicine, Firth College, and the Sheffield Technical School. With a history dating back to as early as the 1810s, the Sheffield School of Medicine is the university's oldest predecessor institution, which is also the oldest higher education establishment in Sheffield. In 1795, the General Infirmary was opened, becoming

23868-565: Was planned on the site. Sir Frederick Mappin later successfully sought financial support from the Sheffield City Council and appealed for public donations. In 1904, steelworkers, coal miners, factory workers and the people of Sheffield donated over £50,000 via penny donations to help found the University of Sheffield. It was originally envisaged that the university college would join Manchester , Liverpool and Leeds as

24024-434: Was pressure on the university to expand since the student numbers had increased from around 1,000 to 3,000 by 1946. The university announced proposals for development in 1947, which emphasised the need for new departments, medical school, library, administration building, halls of residence, as well as the completion of the Western Bank quadrangle and the extension of the Students' Union. The university then grew slowly until

24180-494: Was subsequently formed by the amalgamation of the three institutions in 1897 and was granted a royal charter as University of Sheffield in 1905 by King Edward VII . Sheffield is formed from 50 academic departments which are organised into five faculties and an international faculty. The annual income of the institution for 2022–23 was £880.2 million, of which £198.6 million was from research grants and contracts, with an expenditure of £790.5 million. The university

24336-543: Was £737.5 million, of which £171 million was from research grants and contracts, with an expenditure of £609.2 million resulting in a surplus of £127.1 million. Its endowment was £45.5 million. The arms of the university was granted by the College of Arms on 28 June 1905. It is on an azure shield with a gold-edged book inscribed with the Latin Disce Doce (Learn and Teach) at its centre,

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