Misplaced Pages

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76-706: The park closed permanently on July 31, 2020, due to the impact of the COVID-19 pandemic on its management. The park was themed as Tongari Island (トンガリ島) in the New World; after the Straw Hat Crew landed there, they created games and attractions for their fans with the islanders. The island's leader is Tongari Den Den Mushi who frequently appeared as the guide in some attractions and the website. Tongari (トンガリ) means "pointed" or "sharp" in Japanese and it refers to

152-625: A healthy diet are also recommended. Supportive care in severe cases includes treatment to relieve symptoms , fluid therapy , oxygen support and prone positioning , and medications or devices to support other affected vital organs. More severe cases may need treatment in hospital. In those with low oxygen levels, use of the glucocorticoid dexamethasone is recommended to reduce mortality. Noninvasive ventilation and, ultimately, admission to an intensive care unit for mechanical ventilation may be required to support breathing. Extracorporeal membrane oxygenation (ECMO) has been used to address

228-627: A variant of concern (VoC) or a variant of interest (VoI). Many of these variants have shared the more infectious D614G . As of May 2023, the WHO had downgraded all variants of concern to previously circulating as these were no longer detected in new infections. Sub-lineages of the Omicron variant (BA.1 – BA.5) were considered separate VoCs by the WHO until they were downgraded in March 2023 as no longer widely circulating. As of 24 September 2024 ,

304-512: A casino game where the players bet a certain amount of Berries, the world currency in One Piece, for a three-point match to win a jackpot. The winners with over a certain amount of Berries received a VIP card. An interactive game based on one of Straw Hat Crew, Usopp located on the fourth floor. Players shoot the Marines with a slingshot, Usopp's iconic weapon for a given time. The last enemy

380-493: A comprehensive international study. Such deaths include deaths due to healthcare capacity constraints and priorities, as well as reluctance to seek care (to avoid possible infection). Further research may help distinguish the proportions directly caused by COVID-19 from those caused by indirect consequences of the pandemic. In May 2022, the WHO estimated the number of excess deaths by the end of 2021 to be 14.9 million compared to 5.4 million reported COVID-19 deaths, with

456-608: A higher fatality rate, and there was no effective vaccine until December 2020. In a February 2020 interview, Conservative London mayoral candidate Shaun Bailey argued that London would be able to host the Olympic Games at the former 2012 Olympic venues should the Games need to be moved because of the COVID-19 pandemic. Tokyo Governor Yuriko Koike criticized Bailey's comment as inappropriate. In early 2021, officials in

532-539: A large number of people". During the COVID-19 pandemic, as with other pandemics, the meaning of this term has been challenged. The end of a pandemic or other epidemic only rarely involves the total disappearance of a disease, and historically, much less attention has been given to defining the ends of epidemics than their beginnings. The ends of particular epidemics have been defined in a variety of ways, differing according to academic field, and differently based on location and social group. An epidemic's end can be considered

608-451: A median range of 0.24% to 1.49%. IFRs rise as a function of age (from 0.002% at age 10 and 0.01% at age 25, to 0.4% at age 55, 1.4% at age 65, 4.6% at age 75, and 15% at age 85). These rates vary by a factor of ≈10,000 across the age groups. For comparison, the IFR for middle-aged adults is two orders of magnitude higher than the annualised risk of a fatal automobile accident and much higher than

684-526: A postponement beyond next summer [2021] at the latest". Unlike the case for Zika virus during the 2016 Summer Olympics in Rio de Janeiro, SARS-CoV-2 can be transmitted directly between humans, posing tougher challenges for the organizers to counteract the infectious disease and host a safe and secure event. Also unlike the case for H1N1 "swine flu" during the 2010 Winter Olympics in Vancouver, COVID-19 has

760-400: A press conference on July 15, Koike called on restaurants and other establishments that do not comply with the metropolitan government's guidelines to "avoid using them," and told business operators that they were following the guidelines set by the metropolitan government. As of August 13, about 175,000 stickers have been issued, and the number of stickers has reached about 190,000. Starting on

836-824: A random sample have consistently found that total infections considerably exceed the reported case counts. Many countries, early on, had official policies to not test those with only mild symptoms. The strongest risk factors for severe illness are obesity, complications of diabetes , anxiety disorders, and the total number of conditions. During the start of the COVID-19 pandemic it was not clear whether young people were less likely to be infected, or less likely to develop symptoms and be tested. A retrospective cohort study in China found that children and adults were just as likely to be infected. Among more thorough studies, preliminary results from 9 April 2020 found that in Gangelt ,

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912-473: A search engine, but there was neither a site nor news that explained what to do." In addition, criticism of Tokyo Alert included that the new standards were difficult to understand. The Tokyo Alert was lifted on June 11, the 10th day after it was issued. Yuriko Koike announced on June 12 that she would end the Tokyo Alert and phased closure request system. On the 15th, we decided to consider reviewing

988-461: A social phenomenon, not just a biological one. Time reported in March 2024 that expert opinions differ on whether or not COVID-19 is considered endemic or pandemic, and that the WHO continued to call the disease a pandemic on its website. During the initial outbreak in Wuhan , the virus and disease were commonly referred to as "coronavirus", "Wuhan coronavirus", "the coronavirus outbreak" and

1064-451: A test. Conversely, deaths of people who died from underlying conditions following a positive test may be included. Countries such as Belgium include deaths from suspected cases, including those without a test, thereby increasing counts. Official death counts have been claimed to underreport the actual death toll, because excess mortality (the number of deaths in a period compared to a long-term average) data show an increase in deaths that

1140-756: Is a website published by the Tokyo Metropolitan Government on the spread of COVID-19 infection in Tokyo. Developed by Code for Japan, a general incorporated association, commissioned by the Tokyo Metropolitan Government. Since its release on March 3, 2020, it has exceeded 1 million PV per day. In addition, although it is unusual for a public institution website, it is open source through GitHub and receives feedback. Taking advantage of its characteristics, many derivative sites such as other prefecture versions have appeared. In addition, Taiwan 's Minister of Digital Affairs Audrey Tang participated in

1216-518: Is associated with COVID-19 and is reported in as many as 88% of cases. The disease is mainly transmitted via the respiratory route when people inhale droplets and small airborne particles (that form an aerosol ) that infected people exhale as they breathe, talk, cough, sneeze, or sing. Infected people are more likely to transmit COVID-19 when they are physically close to other non-infected individuals. However, infection can occur over longer distances, particularly indoors. SARS‑CoV‑2 belongs to

1292-628: Is believed that this cluster may also have originated from houseboats. As of May 9, 131 patients and 83 staff members (8 full-time doctors, 60 nurses/nursing assistants, clerks/technicians/contractors, etc.) were confirmed to be infected one after another. 15), a total of 214 infections and 42 deaths have been found. At the Tokyo Metropolitan Bokutoh Hospital in Sumida , infection was confirmed in one patient and one outsourced staff member on April 9, 2020 (announced on

1368-611: Is discouraged altogether by the World Health Organization (WHO), due to limited evidence of its efficacy. The severity of COVID-19 varies. It may take a mild course with few or no symptoms, resembling other common upper respiratory diseases such as the common cold . In 3–4% of cases (7.4% for those over age 65) symptoms are severe enough to cause hospitalisation. Mild cases typically recover within two weeks, while those with severe or critical diseases may take three to six weeks to recover. Among those who have died,

1444-439: Is intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes coronavirus disease 2019 ( COVID-19 ). Prior to the COVID-19 pandemic, an established body of knowledge existed about the structure and function of coronaviruses causing diseases like severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). This knowledge accelerated

1520-490: Is not explained by COVID-19 deaths alone. Using such data, estimates of the true number of deaths from COVID-19 worldwide have included a range from 18.2 to 33.5 million (≈27.4 million) by 18 November 2023 by The Economist , as well as over 18.5 million by 1 April 2023 by the Institute for Health Metrics and Evaluation and ≈18.2 million (earlier) deaths between 1 January 2020, and 31 December 2021, by

1596-409: Is open from 10 a.m. to 10 p.m. A restaurant run by Straw Hat Crew's cook, Sanji located on the ground floor of Tokyo Tower beside Cafe Mugiwara. It offered various meals in buffet style from 11 a.m. to 3 p.m. (maximum 70 minutes stay) and a la carte style from 3 p.m. to 10 p.m. including a course menu and special events related menus. "ORESAMA (俺様)" is a narcissistic way of saying "me" in Japanese and

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1672-452: Is the ratio of deaths to diagnoses. This metric can be misleading because of the delay between symptom onset and death and because testing focuses on symptomatic individuals. Based on Johns Hopkins University statistics, the global CFR was 1.02 percent (6,881,955 deaths for 676,609,955 cases) as of 10 March 2023. The number varies by region and has generally declined over time. Several variants have been named by WHO and labelled as

1748-406: Is the seventh known coronavirus to infect people, after 229E , NL63 , OC43 , HKU1 , MERS-CoV , and the original SARS-CoV . The standard method of testing for presence of SARS-CoV-2 is a nucleic acid test , which detects the presence of viral RNA fragments. As these tests detect RNA but not infectious virus, its "ability to determine duration of infectivity of patients is limited." The test

1824-614: Is typically done on respiratory samples obtained by a nasopharyngeal swab ; however, a nasal swab or sputum sample may also be used. The WHO has published several testing protocols for the disease. Preventive measures to reduce the chances of infection include getting vaccinated, staying at home or spending more time outdoors, avoiding crowded places, keeping distance from others, wearing a mask in public, ventilating indoor spaces, managing potential exposure durations, washing hands with soap and water often and for at least twenty seconds, practising good respiratory hygiene, and avoiding touching

1900-514: The Huanan Seafood Wholesale Market there, but it is possible that human-to-human transmission began earlier. Molecular clock analysis suggests that the first cases were likely to have been between October and November 2019. The scientific consensus is that the virus is most likely of a zoonotic origin, from bats or another closely related mammal. While other explanations such as speculations that SARS-CoV-2

1976-407: The Institute for Health Metrics and Evaluation estimating the true number of cases as of early 2022 to be in the billions. One measure that public health officials and policymakers have used to monitor the pandemic and guide decision-making is the test positivity rate ("percent positive"). According to Johns Hopkins in 2020, one benchmark for a "too high" per cent positive is 5%, which was used by

2052-602: The basic reproduction number (R 0 ) for COVID-19 in January 2020 were between 1.4 and 2.5, but a subsequent analysis claimed that it may be about 5.7 (with a 95 per cent confidence interval of 3.8 to 8.9). In December 2021, the number of cases continued to climb due to several factors, including new COVID-19 variants. As of that 28   December, 282,790,822 individuals worldwide had been confirmed as infected. As of 14 April 2022 , over 500 million cases were confirmed globally. Most cases are unconfirmed, with

2128-474: The variants of interest as specified by the World Health Organization are BA.2.86 and JN.1, and the variants under monitoring are JN.1.7, KP.2, KP.3, KP.3.1.1, JN.1.18, LB.1, and XEC. Symptoms of COVID-19 are variable, ranging from mild symptoms to severe illness. Common symptoms include headache, loss of smell and taste , nasal congestion and runny nose , cough, muscle pain , sore throat , fever, diarrhoea , and breathing difficulties . People with

2204-463: The "Thorough Infection Prevention Declaration Sticker" for the purpose of working on the infection spread prevention guidelines for businesses formulated by the metropolitan government. In the media, it is also known as the rainbow sticker. A checklist that businesses should take to prevent the spread of infection is checked on the web and issued online, and it is used as a guideline to show that businesses are working on infection prevention measures. At

2280-429: The "Wuhan coronavirus outbreak", with the disease sometimes called "Wuhan pneumonia ". In January 2020, the WHO recommended 2019-nCoV and 2019-nCoV acute respiratory disease as interim names for the virus and disease per 2015 international guidelines against using geographical locations (e.g. Wuhan, China), animal species, or groups of people in disease and virus names in part to prevent social stigma . WHO finalised

2356-601: The 14th), and by April 28, 13 patients, 27 staff members, and outsourced staff were infected. A total of 43 infections, including 3 staff members, and 4 deaths have been confirmed. There have been 788 cases detected and reported by the Tokyo 2020 Organising Committee between 1 July and 8 September 2021, with 66 additional cases being detected among Games personnel before that date after the Committee started recording them at an unknown date. The cases have sparked concerns prior to

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2432-399: The 3rd, when restaurants and other establishments were asked to operate at shorter hours, the number of stores that put up the stickers gradually increased, partly due to the fact that posting the stickers was a condition for receiving the cooperation money. Koike says, "I want to fill all of Tokyo with rainbow marks, aiming for 1 million copies". Anyone can print out the stickers by checking

2508-487: The New Year's party of a private taxi union branch in Tokyo held on a yakatabune (houseboat) on January 18, 2023. Two of them were relatives of a male taxi driver in his 70s who was confirmed infected on February 13. A few days before the New Year's party, a yakatabune employee served a tourist from Wuhan. On March 25, 2020, more than a dozen inpatients and nurses were found to be infected at Eiju General Hospital,

2584-854: The U.S. state of Florida offered to host the delayed Games in their state, while John Coates , the IOC vice president in charge of the Tokyo Olympics, said the Games would open even if the city and other parts of Japan were under a state of emergency because of COVID-19. ( Full article... ) COVID-19 pandemic The COVID-19 pandemic (also known as the coronavirus pandemic and COVID pandemic ), caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ), began with an outbreak of COVID-19 in Wuhan , China, in December 2019. It spread to other areas of Asia, and then worldwide in early 2020. The World Health Organization (WHO) declared

2660-640: The WHO in the past. As of 10 March 2023, more than 6.88   million deaths had been attributed to COVID-19. The first confirmed death was in Wuhan on 9 January 2020. These numbers vary by region and over time, influenced by testing volume, healthcare system quality, treatment options, government response, time since the initial outbreak, and population characteristics, such as age, sex, and overall health. Multiple measures are used to quantify mortality. Official death counts typically include people who died after testing positive. Such counts exclude deaths without

2736-419: The WHO, US, European Union, and Australia. On 12 November 2022, the WHO released its Global Vaccine Market Report. The report indicated that "inequitable distribution is not unique to COVID-19 vaccines"; countries that are not economically strong struggle to obtain vaccines. On 14 November 2022, the first inhalable vaccine was introduced, developed by Chinese biopharmaceutical company CanSino Biologics , in

2812-448: The broad family of viruses known as coronaviruses . It is a positive-sense single-stranded RNA (+ssRNA) virus, with a single linear RNA segment. Coronaviruses infect humans, other mammals, including livestock and companion animals, and avian species. Human coronaviruses are capable of causing illnesses ranging from the common cold to more severe diseases such as Middle East respiratory syndrome (MERS, fatality rate ≈34%). SARS-CoV-2

2888-648: The centre of a major infection cluster in Germany, 15 per cent of a population sample tested positive for antibodies . Screening for COVID-19 in pregnant women in New York City , and blood donors in the Netherlands, found rates of positive antibody tests that indicated more infections than reported. Seroprevalence -based estimates are conservative as some studies show that persons with mild symptoms do not have detectable antibodies. Initial estimates of

2964-760: The city of Shanghai, China. For the first two years of the pandemic, no specific and effective treatment or cure was available. In 2021, the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) approved the oral antiviral protease inhibitor , Paxlovid (nirmatrelvir plus the HIV antiviral ritonavir ), to treat adult patients. FDA later gave it an EUA. Most cases of COVID-19 are mild. In these, supportive care includes medication such as paracetamol or NSAIDs to relieve symptoms (fever, body aches, cough), adequate intake of oral fluids and rest. Good personal hygiene and

3040-406: The criteria for issuing alerts. In the two weeks after the alert was lifted (June 12–25), the total number of infected people was 500, almost double the total of 252 in the previous two weeks (May 29-June 11). The Tokyo metropolitan government was cautious about reissuing the alert, fearing that economic activity would stagnate again. The Tokyo Metropolitan Government COVID-19 Countermeasures Site

3116-484: The cumulative number of infected individuals (including asymptomatic and undiagnosed infections and excluding vaccinated infected individuals). It is expressed in percentage points. Other studies refer to this metric as the infection fatality risk . In November 2020, a review article in Nature reported estimates of population-weighted IFRs for various countries, excluding deaths in elderly care facilities, and found

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3192-441: The development of various vaccine platforms during early 2020. The initial focus of SARS-CoV-2 vaccines was on preventing symptomatic and severe illness. The COVID-19 vaccines are widely credited for their role in reducing the severity and death caused by COVID-19. As of March 2023, more than 5.5 billion people had received one or more doses (11.8 billion in total) in over 197 countries. The Oxford-AstraZeneca vaccine

3268-513: The eyes, nose, or mouth with unwashed hands. Those diagnosed with COVID-19 or who believe they may be infected are advised by healthcare authorities to stay home except to get medical care, call ahead before visiting a healthcare provider, wear a face mask before entering the healthcare provider's office and when in any room or vehicle with another person, cover coughs and sneezes with a tissue, regularly wash hands with soap and water and avoid sharing personal household items. A COVID-19 vaccine

3344-475: The feedback. It provides real-time information in an easy-to-read, simple design. It is open source and can be used by anyone. It also supports six languages: Japanese, English, Chinese (simplified and traditional), Korean, and simple Japanese. Information such as the status of testing and the number of infected people is displayed in a graph -based design, and the latest news and consultation methods are also explained. The Tokyo Metropolitan Government issued

3420-449: The first floor of Tokyo Tower that offered foods and beverages inspired by different characters and stories from One Piece. It had more than six hundred books and comics from the world related to ONE PIECE, including original manga series, for visitors to read freely while they eat and rest. It offered special monthly birthday menus for a certain character from One Piece. Also, it often collaborates with other events such as Ichiban Kuji It

3496-517: The first personal pronoun Sanji refers to himself in the One Piece series. His statue stood between Mugiwara Cafe and Sanji's ORESAMA Restaurant. The interiors imitated various items or scenes from ONE PIECE such as a mast, prison bars, etc. for visitors to indulge in the world of ONE PIECE. COVID-19 pandemic in Tokyo The first case relating to the COVID-19 pandemic in Tokyo , Japan,

3572-592: The fourth floor involving the whole park. The players were given one Transponder Snail to find many ancient characters hidden all over the park to finally discover Poneglyph in the ancient remains. An area dedicated to the shipwright, Franky on the fourth floor. There was a pinball machine called "Franky's Ball Run" in the shape of Franky, a colorful children’s area with toys, and a small cafe called Franky's Cola Bar offering light meals and beverages. A haunted house based on one of Straw Hat Crew, Brook. The players were given one salt ball (塩玉) to defeat zombies roaming inside

3648-400: The fourth floor. Inside was a Dojo that Zoro established and the players must slash down cannons fired from the screen in front to defeat Marines with a sword using Zoro's skills. Also, Zoro's and other characters' swords and weapons were displayed on the wall inside this attraction. An interactive attraction based on the navigator of Straw Hat Crew, Nami located on the fourth floor. It was

3724-528: The games. The bubble surrounding the Olympic Village has been described as having been broken after the first case occurred there in mid-July. ( Full article... ) According to the Tokyo Metropolitan Government, Tokyo Alert was "an accurate notification of the infection situation in Tokyo and a call for vigilance". The purpose is to issue early warning information and prevent the re-expansion of infection. Tokyo Alert does not impose any restrictions on

3800-474: The general public beginning in December 2020, made available through government and international programs such as COVAX , aiming to provide vaccine equity . Treatments include novel antiviral drugs and symptom control. Common mitigation measures during the public health emergency included travel restrictions , lockdowns , business restrictions and closures, workplace hazard controls , mask mandates , quarantines, testing systems, and contact tracing of

3876-437: The haunted house. There were numerous photo spots inside the park including characters’ life-size statues, portraits, special exhibitions, etc. One Piece Live Attraction original entertainment show where live One Piece characters unfolded an adventurous story on stage. The theater was located on the 5th floor. Approximately four to six shows were held every day. The storyline changes seasonally. A merchandise shop inside

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3952-665: The infected. The pandemic caused severe social and economic disruption around the world, including the largest global recession since the Great Depression . Widespread supply shortages , including food shortages , were caused by supply chain disruptions and panic buying . Reduced human activity led to an unprecedented temporary decrease in pollution . Educational institutions and public areas were partially or fully closed in many jurisdictions, and many events were cancelled or postponed during 2020 and 2021. Telework became much more common for white-collar workers as

4028-451: The island. A walkthrough attraction that followed the history of the protagonist, Monkey D. Luffy and his fellow characters. It was located on the 5th floor. There were life-size statues of characters, miniatures, and exhibition panels. There was a movie theater with a wide screen at the end showing an original short film only available at Tokyo One Piece Tower. An interactive game based on one of Straw Hat Crew, Roronoa Zoro located on

4104-487: The issue of respiratory failure. Existing drugs such as hydroxychloroquine , lopinavir/ritonavir , and ivermectin are not recommended by US or European health authorities, as there is no good evidence they have any useful effect. The antiviral remdesivir is available in the US, Canada, Australia, and several other countries, with varying restrictions; however, it is not recommended for use with mechanical ventilation, and

4180-415: The items on the Tokyo Metropolitan Government website. In August, a mass infection was confirmed at a restaurant that posted the sticker, and the Tokyo Metropolitan Government said, "We will check to what extent the guidelines have been followed." The Tokyo One Piece Tower closed down permanently on July 31, 2020, due to the impact of the pandemic on its management. The 2020 Tokyo Rainbow Pride parade

4256-581: The largest in Taitō , Tokyo. According to the Tokyo metropolitan government, this is the first case of a suspected group infection in a hospital. Mayor Yukio Hattori of Taito Ward established the Taito Ward Novel Coronavirus Infectious Diseases Control Council, which is composed of people involved in medical institutions. It announced that it would open in hospitals and wards. In addition, it

4332-502: The lives of Tokyo residents, and is merely a call for vigilance by the city. On 2 June 2020, Tokyo Alert was issued due to the risk of infection spreading mainly in downtown areas and hospitals at night. The Rainbow Bridge and the Tokyo Metropolitan Government Building were lit up in red. Journalist Toshinao Sasaki said in a radio program, "I wondered what Tokyo Alert was, so I looked it up on

4408-576: The majority of the unreported 9.5 million deaths believed to be direct deaths due the virus, rather than indirect deaths. Some deaths were because people with other conditions could not access medical services . A December 2022 WHO study estimated excess deaths from the pandemic during 2020 and 2021, again concluding ≈14.8 million excess early deaths occurred, reaffirming and detailing their prior calculations from May as well as updating them, addressing criticisms. These numbers do not include measures like years of potential life lost and may make

4484-495: The official names COVID-19 and SARS-CoV-2 on 11 February 2020. Tedros Adhanom Ghebreyesus explained: CO   for corona , VI   for virus , D   for disease and 19 for when the outbreak was first identified (31 December 2019). WHO additionally uses "the COVID-19 virus" and "the virus responsible for COVID-19" in public communications. WHO named variants of concern and variants of interest using Greek letters . The initial practice of naming them according to where

4560-534: The outbreak a public health emergency of international concern (PHEIC) on 30 January 2020, and assessed the outbreak as having become a pandemic on 11 March. COVID-19 symptoms range from asymptomatic to deadly, but most commonly include fever, sore throat , nocturnal cough , and fatigue. Transmission of the virus is often through airborne particles . Mutations have produced many strains (variants) with varying degrees of infectivity and virulence . COVID-19 vaccines were developed rapidly and deployed to

4636-407: The pandemic 2021's leading cause of death . The time between symptom onset and death ranges from   6 to 41 days, typically about 14 days. Mortality rates increase as a function of age. People at the greatest mortality risk are the elderly and those with underlying conditions. The infection fatality ratio (IFR) is the cumulative number of deaths attributed to the disease divided by

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4712-495: The pandemic evolved. Misinformation circulated through social media and mass media , and political tensions intensified . The pandemic raised issues of racial and geographic discrimination , health equity , and the balance between public health imperatives and individual rights . The WHO ended the PHEIC for COVID-19 on 5 May 2023. The disease has continued to circulate, but as of 2024, experts were uncertain as to whether it

4788-476: The park on the third floor offering exclusive goods and items with original designs only at Tokyo One Piece Tower. A One Piece official merchandise shop outside the park on the first floor of Tokyo Tower offering One Piece goods and items. There were exclusive items only on sale at Tokyo Tower. A small cafe inside the park managed by Coca-Cola lover Franky. It offered various light meals and beverages, and some tables and chairs to rest. A library cafe located on

4864-478: The population's age structure and the age-specific pattern of infections. There have also been reviews that have compared the fatality rate of this pandemic with prior pandemics, such as MERS-CoV. For comparison the infection mortality rate of seasonal flu in the United States is 0.1%, which is 13 times lower than COVID-19. Another metric in assessing death rate is the case fatality ratio (CFR), which

4940-462: The risk of dying from seasonal influenza . In December 2020, a systematic review and meta-analysis estimated that population-weighted IFR was 0.5% to 1% in some countries (France, Netherlands, New Zealand, and Portugal), 1% to 2% in other countries (Australia, England, Lithuania, and Spain), and about 2.5% in Italy. This study reported that most of the differences reflected corresponding differences in

5016-496: The same infection may have different symptoms, and their symptoms may change over time. Three common clusters of symptoms have been identified: one respiratory symptom cluster with cough, sputum , shortness of breath, and fever; a musculoskeletal symptom cluster with muscle and joint pain, headache, and fatigue; a cluster of digestive symptoms with abdominal pain, vomiting, and diarrhoea. In people without prior ear, nose, and throat disorders, loss of taste combined with loss of smell

5092-530: The shape of Tokyo Tower. In 2016, it ranked 7th in TripAdvisor 2016 Traveler's Choice Top 10 Amusement Parks in the Japan region. An experiential attraction where the famous scenes of Straw Hat Crew adventure from the manga series were projected onto a 360 degree omnidirectional screen. It was located on the third floor, the entrance floor of One Piece Tower, and was the first attraction to welcome visitors to

5168-411: The time from symptom onset to death has ranged from two to eight weeks. Prolonged prothrombin time and elevated C-reactive protein levels on admission to the hospital are associated with severe course of COVID-19 and with a transfer to intensive care units (ICU). Between 5% and 50% of COVID-19 patients experience long COVID , a condition characterised by long-term consequences persisting after

5244-694: The typical convalescence period of the disease. The most commonly reported clinical presentations are fatigue and memory problems, as well as malaise , headaches, shortness of breath , loss of smell, muscle weakness , low fever and cognitive dysfunction . Many countries attempted to slow or stop the spread of COVID-19 by recommending, mandating or prohibiting behaviour changes, while others relied primarily on providing information. Measures ranged from public advisories to stringent lockdowns. Outbreak control strategies are divided into elimination and mitigation. Experts differentiate between elimination strategies (known as " zero-COVID ") that aim to completely stop

5320-543: The variants were identified (e.g. Delta began as the " Indian variant") is no longer common. A more systematic naming scheme reflects the variant's PANGO lineage (e.g., Omicron 's lineage is B.1.1.529) and is used for other variants. SARS-CoV-2 is a virus closely related to bat coronaviruses , pangolin coronaviruses, and SARS-CoV . The first known outbreak (the 2019–2020 COVID-19 outbreak in mainland China ) started in Wuhan , Hubei, China, in December 2019. Many early cases were linked to people who had visited

5396-443: Was accidentally released from a laboratory have been proposed, as of 2021 these were not supported by evidence. Official "case" counts refer to the number of people who have been tested for COVID-19 and whose test has been confirmed positive according to official protocols whether or not they experienced symptomatic disease. Due to the effect of sampling bias , studies which obtain a more accurate number by extrapolating from

5472-683: Was cancelled. In January 2020, concerns were raised about the potential impact of the COVID-19 pandemic on athletes and visitors to the Summer Olympic Games. Tokyo organizers and the International Olympic Committee insisted they were monitoring the spread of the disease to minimize its effects on preparations for the Olympics. The IOC stated that in 2020, their Japanese partners and Prime Minister Shinzo Abe "made it very clear that Japan could not manage

5548-661: Was confirmed on January 24, 2020, and on February 13, 2020, the first infection of a Tokyo resident was confirmed. On March 26, 2020, the Tokyo Metropolitan Government established the "Tokyo Novel Coronavirus Infectious Diseases Control Headquarters" based on the Act on Special Measures against New Influenza. As of July 31, 2022, the highest daily number of infected people in Tokyo was confirmed on July 28, 2022, with 40,406 people. On February 14, 2020, multiple infected people were confirmed among attendees of

5624-457: Was still a pandemic. Pandemics and their ends are not well-defined, and whether or not one has ended differs according to the definition used. As of 24 November 2024, COVID-19 has caused 7,075,455 confirmed deaths. The COVID-19 pandemic ranks as the fifth- deadliest pandemic or epidemic in history . In epidemiology , a pandemic is defined as "an epidemic occurring over a very wide area, crossing international boundaries, and usually affecting

5700-490: Was the World Government. An interactive walkthrough attraction guided by one of Straw Hat Crew, Tony Tony Chopper located on the fourth floor. The whole attraction imitated the interior of Straw Hat Crew's second ship, Thousand Sunny. It included the kitchen and dining, Nami and Robin's bedroom, and other facilities inside Thousand Sunny. An interactive game based on one of Straw Hat Crew, Nico Robin located on

5776-509: Was the most widely used. According to a June 2022 study, COVID-19 vaccines prevented an additional 14.4 million to 19.8 million deaths in 185 countries and territories from 8 December 2020 to 8 December 2021. On 8 November 2022, the first recombinant protein-based COVID-19 vaccine (Novavax's booster Nuvaxovid ) was authorised for use in adults in the United Kingdom. It has subsequently received endorsement/authorisation from

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