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78-437: Varicose veins have no specific cause. Risk factors include obesity , lack of exercise, leg trauma, and family history of the condition. They also develop more commonly during pregnancy . Occasionally they result from chronic venous insufficiency . Underlying causes include weak or damaged valves in the veins. They are typically diagnosed by examination, including observation by ultrasound . By contrast, spider veins affect

156-578: A gastric balloon or surgery may be performed to reduce stomach volume or length of the intestines, leading to feeling full earlier, or a reduced ability to absorb nutrients from food. Many do not realize that metabolic surgery is not only about reducing intake, it has also been shown to alter gut hormones for a period of time. Obesity is a leading preventable cause of death worldwide, with increasing rates in adults and children . In 2022, over 1 billion people lived with obesity worldwide (879 million adults and 159 million children), representing more than

234-476: A randomised controlled trial on patients with and without routine ultrasound have shown a significant difference in recurrence rate and reoperation rate at 2 and 7 years of follow-up. The CEAP (Clinical, Etiological, Anatomical, and Pathophysiological) Classification, developed in 1994 by an international ad hoc committee of the American Venous Forum , outlines these stages Each clinical class

312-658: A 1.67-fold greater risk of obesity compared with those without the risk allele . The differences in BMI between people that are due to genetics varies depending on the population examined from 6% to 85%. Obesity is a major feature in several syndromes, such as Prader–Willi syndrome , Bardet–Biedl syndrome , Cohen syndrome , and MOMO syndrome . (The term "non-syndromic obesity" is sometimes used to exclude these conditions.) In people with early-onset severe obesity (defined by an onset before 10 years of age and body mass index over three standard deviations above normal), 7% harbor

390-477: A BMI of 30–35 kg/m reduces life expectancy by two to four years, while severe obesity (BMI ≥ 40 kg/m ) reduces life expectancy by ten years. Obesity increases the risk of many physical and mental conditions. These comorbidities are most commonly shown in metabolic syndrome , a combination of medical disorders which includes: diabetes mellitus type 2 , high blood pressure , high blood cholesterol , and high triglyceride levels . A study from

468-401: A cause of recurrent varicose veins. There is increasing evidence for the role of incompetent perforator veins (or "perforators") in the formation of varicose veins. and recurrent varicose veins. Varicose veins could also be caused by hyperhomocysteinemia in the body, which can degrade and inhibit the formation of the three main structural components of the artery: collagen , elastin and

546-570: A double of adult cases (and four times higher than cases among children) registered in 1990. Obesity is more common in women than in men. Today, obesity is stigmatized in most of the world. Conversely, some cultures, past and present, have a favorable view of obesity, seeing it as a symbol of wealth and fertility. The World Health Organization , the US, Canada, Japan, Portugal, Germany, the European Parliament and medical societies, e.g.

624-671: A greater prevalence of labor-saving technology in the home. In children, there appear to be declines in levels of physical activity (with particularly strong declines in the amount of walking and physical education), likely due to safety concerns, changes in social interaction (such as fewer relationships with neighborhood children), and inadequate urban design (such as too few public spaces for safe physical activity). World trends in active leisure time physical activity are less clear. The World Health Organization indicates people worldwide are taking up less active recreational pursuits, while research from Finland found an increase and research from

702-586: A high social class were less likely to be obese. No significant differences were seen among men of different social classes. In the developing world, women, men, and children from high social classes had greater rates of obesity. In 2007 repeating the same research found the same relationships, but they were weaker. The decrease in strength of correlation was felt to be due to the effects of globalization . Among developed countries, levels of adult obesity, and percentage of teenage children who are overweight, are correlated with income inequality . A similar relationship

780-757: A lack of physical activity as the cause of most cases of obesity. A limited number of cases are due primarily to genetics, medical reasons, or psychiatric illness. In contrast, increasing rates of obesity at a societal level are felt to be due to an easily accessible and palatable diet, increased reliance on cars , and mechanized manufacturing. Some other factors have been proposed as causes towards rising rates of obesity worldwide, including insufficient sleep , endocrine disruptors , increased usage of certain medications (such as atypical antipsychotics ), increases in ambient temperature, decreased rates of smoking , demographic changes, increasing maternal age of first-time mothers, changes to epigenetic dysregulation from

858-564: A lower BMI than Caucasians , some nations have redefined obesity; Japan has defined obesity as any BMI greater than 25 kg/m while China uses a BMI of greater than 28 kg/m . The preferred obesity metric in scholarly circles is the body fat percentage (BF%) – the ratio of the total weight of person's fat to his or her body weight, and BMI is viewed merely as a way to approximate BF%. According to American Society of Bariatric Physicians , levels in excess of 32% for women and 25% for men are generally considered to indicate obesity. BMI

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936-424: A majority of people living with obesity at any given time attempt to lose weight and are often successful, maintaining weight loss long-term is rare. There is no effective, well-defined, evidence-based intervention for preventing obesity. Obesity prevention requires a complex approach, including interventions at medical, societal, community, family, and individual levels. Changes to diet as well as exercising are

1014-633: A man's risk increases by 4% per child. This could be partly explained by the fact that having dependent children decreases physical activity in Western parents. In the developing world urbanization is playing a role in increasing rate of obesity. In China overall rates of obesity are below 5%; however, in some cities rates of obesity are greater than 20%. In part, this may be because of urban design issues (such as inadequate public spaces for physical activity). Time spent in motor vehicles, as opposed to active transportation options such as cycling or walking,

1092-450: A multidisciplinary team rather than "eat less, move more" being the answer as for most living with obesity, diet & exercise have failed them countless times. There is now a scientific realization where 5% of people with this disease are able to lose & maintain loss through this method as the body will adapt & reach a plateau where for most, it begins to push back towards set point. Also that bodies react differently to energy. So too

1170-487: A natural agent, fast recovery to daily activities). ELA and ERA require specialized training for doctors and special equipment. ELA is performed as an outpatient procedure and does not require an operating theatre, nor does the patient need a general anaesthetic . Doctors use high-frequency ultrasound during the procedure to visualize the anatomical relationships between the saphenous structures. Some practitioners also perform phlebectomy or ultrasound-guided sclerotherapy at

1248-404: A phenomenon known as the obesity survival paradox. The paradox was first described in 1999 in overweight and obese people undergoing hemodialysis and has subsequently been found in those with heart failure and peripheral artery disease (PAD). In people with heart failure, those with a BMI between 30.0 and 34.9 had lower mortality than those with a normal weight. This has been attributed to

1326-576: A recurrence rate of 33%, to open surgery, which had a recurrence rate of 23%. Steam treatment consists in injection of pulses of steam into the sick vein. This treatment which works with a natural agent (water) has results similar to laser or radiofrequency. The steam presents a lot of post-operative advantages for the patient (good aesthetic results, less pain, etc.) Steam is a very promising treatment for both doctors (easy introduction of catheters, efficient on recurrences, ambulatory procedure, easy and economic procedure) and patients (less post-operative pain,

1404-495: A significant effect on an individual's weight. Those who quit smoking gain an average of 4.4 kilograms (9.7 lb) for men and 5.0 kilograms (11.0 lb) for women over ten years. However, changing rates of smoking have had little effect on the overall rates of obesity. In the United States, the number of children a person has is related to their risk of obesity. A woman's risk increases by 7% per child, while

1482-950: A single point DNA mutation. Studies that have focused on inheritance patterns rather than on specific genes have found that 80% of the offspring of two obese parents were also obese, in contrast to less than 10% of the offspring of two parents who were of normal weight. Different people exposed to the same environment have different risks of obesity due to their underlying genetics. The thrifty gene hypothesis postulates that, due to dietary scarcity during human evolution, people are prone to obesity. Their ability to take advantage of rare periods of abundance by storing energy as fat would be advantageous during times of varying food availability, and individuals with greater adipose reserves would be more likely to survive famine . This tendency to store fat, however, would be maladaptive in societies with stable food supplies. This theory has received various criticisms, and other evolutionarily-based theories such as

1560-434: A small incision and no hospital stay, medical super glue has generated great interest within the last years, with a success rate of about 96.8%. A follow-up consultation is required after this treatment, just like any other one, in order to re-assess the diseased vein and further treat it if needed. In the field of varicose veins, the latest medical innovation is high-intensity focused ultrasound therapy ( HIFU ). This method

1638-711: Is 39 months. Two prospective randomized trials found speedier recovery and fewer complications after radiofrequency ablation (ERA) compared to open surgery. Myers wrote that open surgery for small saphenous vein reflux is obsolete. Myers said these veins should be treated with endovenous techniques, citing high recurrence rates after surgical management, and risk of nerve damage up to 15%. By comparison ERA has been shown to control 80% of cases of small saphenous vein reflux at 4 years, said Myers. Complications for ERA include burns, paraesthesia, clinical phlebitis and slightly higher rates of deep vein thrombosis (0.57%) and pulmonary embolism (0.17%). One 3-year study compared ERA, with

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1716-537: Is a major cause of disability and is correlated with various diseases and conditions , particularly cardiovascular diseases , type 2 diabetes , obstructive sleep apnea , certain types of cancer , and osteoarthritis . Obesity has individual, socioeconomic, and environmental causes. Some known causes are diet, physical activity, automation , urbanization , genetic susceptibility , medications , mental disorders , economic policies , endocrine disorders , and exposure to endocrine-disrupting chemicals . While

1794-476: Is a medical condition, sometimes considered a disease , in which excess body fat has accumulated to such an extent that it can potentially have negative effects on health . People are classified as obese when their body mass index (BMI)—a person's weight divided by the square of the person's height—is over 30  kg / m ; the range 25–30  kg / m is defined as overweight . Some East Asian countries use lower values to calculate obesity. Obesity

1872-430: Is an advanced non-surgical treatment for varicose veins during which a solution is injected into the diseased vein through a small catheter and under the assistance of ultrasound-guided imagery. The "super glue" solution is made of cyanoacrylate, aiming at sealing the vein and rerouting the blood flow to other healthy veins. Post-treatment, the body will naturally absorb the treated vein which will disappear. Involving only

1950-553: Is an indication that gut flora can affect the metabolic potential. This apparent alteration is believed to confer a greater capacity to harvest energy contributing to obesity. Whether these differences are the direct cause or the result of obesity has yet to be determined unequivocally. The use of antibiotics among children has also been associated with obesity later in life. An association between viruses and obesity has been found in humans and several different animal species. The amount that these associations may have contributed to

2028-571: Is believed to be contributing to the rising rates of obesity and to an increased risk of metabolic syndrome and type 2 diabetes . Vitamin D deficiency is related to diseases associated with obesity. As societies become increasingly reliant on energy-dense , big-portions, and fast-food meals, the association between fast-food consumption and obesity becomes more concerning. In the United States, consumption of fast-food meals tripled and food energy intake from these meals quadrupled between 1977 and 1995. Agricultural policy and techniques in

2106-523: Is chronic alcohol consumption due to the vasodilatation side effect in relation to gravity and blood viscosity. Clinical tests that may be used include: Traditionally, varicose veins were investigated using imaging techniques only if there was a suspicion of deep venous insufficiency, if they were recurrent, or if they involved the saphenopopliteal junction. This practice is now less widely accepted. People with varicose veins should now be investigated using lower limbs venous ultrasonography . The results from

2184-399: Is completely non-invasive and is not necessarily performed in an operating room, unlike existing techniques. This is because the procedure involves treating from outside the body, able to penetrate the skin without damage, to treat the veins in a targeted area. This leaves no scars and allows the patient to return to their daily life immediately. Varicose veins are most common after age 50. It

2262-462: Is correlated with increased risk of obesity. Malnutrition in early life is believed to play a role in the rising rates of obesity in the developing world . Endocrine changes that occur during periods of malnutrition may promote the storage of fat once more food energy becomes available. The study of the effect of infectious agents on metabolism is still in its early stages. Gut flora has been shown to differ between lean and obese people. There

2340-441: Is further characterized by a subscript depending upon whether the patient is symptomatic (S) or asymptomatic (A), e.g. C2S. Treatment can be either active or conservative. Treatment options include surgery, laser and radiofrequency ablation , and ultrasound-guided foam sclerotherapy . Newer treatments include cyanoacrylate glue, mechanochemical ablation, and endovenous steam ablation. No real difference could be found between

2418-494: Is more prevalent in females. There is a hereditary role. It has been seen in smokers, those who have chronic constipation , and in people with occupations which necessitate long periods of standing such as wait staff, nurses, conductors (musical and bus), stage actors, umpires (cricket, javelin, etc.), the King's guards, lectern orators, security guards, traffic police officers, vendors, surgeons, etc. Obesity Obesity

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2496-626: Is not known if sclerotherapy decreases the chance of varicose veins returning (recurrent varicose veins). It is also not known which type of substance (liquid or foam) used for the sclerotherapy procedure is more effective and comes with the lowest risk of complications. Complications of sclerotherapy are rare, but can include blood clots and ulceration. Anaphylactic reactions are "extraordinarily rare but can be life-threatening," and doctors should have resuscitation equipment ready. There has been one reported case of stroke after ultrasound-guided sclerotherapy when an unusually large dose of sclerosant foam

2574-897: Is not regarded as a psychiatric disorder, and therefore is not listed in the DSM-IVR as a psychiatric illness. The risk of overweight and obesity is higher in patients with psychiatric disorders than in persons without psychiatric disorders. Obesity and depression influence each other mutually, with obesity increasing the risk of clinical depression, and also depression leading to a higher chance of developing obesity. Certain medications may cause weight gain or changes in body composition ; these include insulin , sulfonylureas , thiazolidinediones , atypical antipsychotics , antidepressants , steroids , certain anticonvulsants ( phenytoin and valproate ), pizotifen , and some forms of hormonal contraception . While genetic influences are important to understanding obesity, they cannot completely explain

2652-414: Is now viewed as outdated in numerous countries. It ignores variations between individuals in amounts of lean body mass, particularly muscle mass. Individuals involved in heavy physical labor or sports may have high BMI values despite having little fat. For example, more than half of all NFL players are classified as "obese" (BMI ≥ 30), and 1 in 4 are classified as "extremely obese" (BMI ≥ 35), according to

2730-451: Is seen among US states: more adults, even in higher social classes, are obese in more unequal states. Many explanations have been put forth for associations between BMI and social class. It is thought that in developed countries, the wealthy are able to afford more nutritious food, they are under greater social pressure to remain slim, and have more opportunities along with greater expectations for physical fitness . In undeveloped countries

2808-445: Is seen in the overweight and obese. One study found that the improved survival could be explained by the more aggressive treatment obese people receive after a cardiac event. Another study found that if one takes into account chronic obstructive pulmonary disease (COPD) in those with PAD, the benefit of obesity no longer exists. The " a calorie is a calorie " model of obesity posits a combination of excessive food energy intake and

2886-426: Is still somewhat controversial, and there is no clear evidence that foams are superior. Sclerotherapy has been used in the treatment of varicose veins for over 150 years. Sclerotherapy is often used for telangiectasias (spider veins) and varicose veins that persist or recur after vein stripping. Sclerotherapy can also be performed using foamed sclerosants under ultrasound guidance to treat larger varicose veins, including

2964-403: Is supported both by tests of people carried out in a calorimeter room and by direct observation. A sedentary lifestyle may play a significant role in obesity. Worldwide there has been a large shift towards less physically demanding work, and currently at least 30% of the world's population gets insufficient exercise. This is primarily due to increasing use of mechanized transportation and

3042-549: Is the result of an interplay between genetic and environmental factors. Polymorphisms in various genes controlling appetite and metabolism predispose to obesity when sufficient food energy is present. As of 2006, more than 41 of these sites on the human genome have been linked to the development of obesity when a favorable environment is present. People with two copies of the FTO gene (fat mass and obesity associated gene) have been found on average to weigh 3–4 kg more and have

3120-540: The American Medical Association , classify obesity as a disease. Others, such as the UK , do not. Obesity is typically defined as a substantial accumulation of body fat that could impact health. Medical organizations tend to classify people living with obesity as based on body mass index (BMI) – a ratio of a person's weight in kilograms to the square of their height in meters . For adults,

3198-500: The Endocrine Society , there is "growing evidence suggesting that obesity is a disorder of the energy homeostasis system, rather than simply arising from the passive accumulation of excess weight". Excess appetite for palatable, high-calorie food (especially fat, sugar, and certain animal proteins) is seen as the primary factor driving obesity worldwide, likely because of imbalances in neurotransmitters affecting

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3276-496: The RAK Hospital found that obese people are at a greater risk of developing long COVID . The CDC has found that obesity is the single strongest risk factor for severe COVID-19 illness. Complications are either directly caused by obesity or indirectly related through mechanisms sharing a common cause such as a poor diet or a sedentary lifestyle . The strength of the link between obesity and specific conditions varies. One of

3354-513: The World Health Organization (WHO) defines " overweight " as a BMI 25 or higher, and "obesity" as a BMI 30 or higher. The U.S. Centers for Disease Control and Prevention (CDC) further subdivides obesity based on BMI, with a BMI 30 to 35 called class 1 obesity; 35 to 40, class 2 obesity; and 40+, class 3 obesity. For children, obesity measures take age into consideration along with height and weight. For children aged 5–19,

3432-695: The capillaries and are smaller. Treatment may involve lifestyle changes or medical procedures with the goal of improving symptoms and appearance. Lifestyle changes may include wearing compression stockings , exercising, elevating the legs, and weight loss. Possible medical procedures include sclerotherapy , laser surgery , and vein stripping . However, recurrence is common following treatment. Varicose veins are very common, affecting about 30% of people at some point in their lives. They become more common with age. Women develop varicose veins about twice as often as men. Varicose veins have been described throughout history and have been treated with surgery since at least

3510-543: The drifty gene hypothesis and the thrifty phenotype hypothesis have also been proposed. Certain physical and mental illnesses and the pharmaceutical substances used to treat them can increase risk of obesity. Medical illnesses that increase obesity risk include several rare genetic syndromes (listed above) as well as some congenital or acquired conditions: hypothyroidism , Cushing's syndrome , growth hormone deficiency , and some eating disorders such as binge eating disorder and night eating syndrome . However, obesity

3588-553: The proteoglycans . Homocysteine permanently degrades cysteine disulfide bridges and lysine amino acid residues in proteins , gradually affecting function and structure. Simply put, homocysteine is a 'corrosive' of long-living proteins, i.e. collagen or elastin , or lifelong proteins, i.e. fibrillin . These long-term effects are difficult to establish in clinical trials focusing on groups with existing artery decline. Klippel–Trenaunay syndrome and Parkes Weber syndrome are relevant for differential diagnosis . Another cause

3666-599: The BMI metric. However, their mean body fat percentage , 14%, is well within what is considered a healthy range. Similarly, Sumo wrestlers may be categorized by BMI as "severely obese" or "very severely obese" but many Sumo wrestlers are not categorized as obese when body fat percentage is used instead (having <25% body fat). Some Sumo wrestlers were found to have no more body fat than a non-Sumo comparison group, with high BMI values resulting from their high amounts of lean body mass. Canada utilises BMI sparingly within their method of defining levels of obesity through use of

3744-655: The BioSHaRE– EU Healthy Obese Project (sponsored by Maelstrom Research, a team under the Research Institute of the McGill University Health Centre ) came up with two definitions for healthy obesity , one more strict and one less so: To come up with these criteria, BioSHaRE controlled for age and tobacco use, researching how both may effect the metabolic syndrome associated with obesity, but not found to exist in

3822-489: The Edmonton Scale (for adult obesity). This scale also introduces factors such as Quality of Life, Mental Health & Mobility amongst others. In recent years, Canada chose to allow both Chilli & Ireland to adapt their obesity guidelines to suit both countries' health systems. In Ireland, obesity is now defined as "a Complex, Chronic & Relapsing Disease". Therefore it is now viewed as requiring intervention from

3900-527: The United States and Europe have led to lower food prices . In the United States, subsidization of corn, soy, wheat, and rice through the U.S. farm bill has made the main sources of processed food cheap compared to fruits and vegetables. Calorie count laws and nutrition facts labels attempt to steer people toward making healthier food choices, including awareness of how much food energy is being consumed. Obese people consistently under-report their food consumption as compared to people of normal weight. This

3978-455: The United States found leisure-time physical activity has not changed significantly. Physical activity in children may not be a significant contributor. In both children and adults, there is an association between television viewing time and the risk of obesity. Increased media exposure increases the rate of childhood obesity, with rates increasing proportionally to time spent watching television. Like many other medical conditions, obesity

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4056-894: The United States increased from 14.5% to 30.9%. During the same period, an increase occurred in the average amount of food energy consumed. For women, the average increase was 335 calories (1,400 kJ) per day (1,542 calories (6,450 kJ) in 1971 and 1,877 calories (7,850 kJ) in 2004), while for men the average increase was 168 calories (700 kJ) per day (2,450 calories (10,300 kJ) in 1971 and 2,618 calories (10,950 kJ) in 2004). Most of this extra food energy came from an increase in carbohydrate consumption rather than fat consumption. The primary sources of these extra carbohydrates are sweetened beverages, which now account for almost 25 percent of daily food energy in young adults in America, and potato chips. Consumption of sweetened beverages such as soft drinks, fruit drinks, and iced tea

4134-520: The United States, Aethoxysklerol in Australia), sodium tetradecyl sulphate (STS), Sclerodex (Canada), hypertonic saline, glycerin and chromated glycerin. STS (branded Fibrovein in Australia) liquids can be mixed at varying concentrations of sclerosant and varying sclerosant/gas proportions, with air or CO 2 or O 2 to create foams. Foams may allow more veins to be treated per session with comparable efficacy. Their use in contrast to liquid sclerosant

4212-628: The WHO defines obesity as a BMI two standard deviations above the median for their age (a BMI around 18 for a five-year old; around 30 for a 19-year old). For children under five, the WHO defines obesity as a weight three standard deviations above the median for their height. Some modifications to the WHO definitions have been made by particular organizations. The surgical literature breaks down class II and III or only class III obesity into further categories whose exact values are still disputed. As Asian populations develop negative health consequences at

4290-450: The ability to afford food, high energy expenditure with physical labor, and cultural values favoring a larger body size are believed to contribute to the observed patterns. Attitudes toward body weight held by people in one's life may also play a role in obesity. A correlation in BMI changes over time has been found among friends, siblings, and spouses. Stress and perceived low social status appear to increase risk of obesity. Smoking has

4368-471: The association of BMI and waist circumference with mortality is U- or J-shaped, while the association between waist-to-hip ratio and waist-to-height ratio with mortality is more positive. In Asians the risk of negative health effects begins to increase between 22 and 25 kg/m . In 2021, the World Health Organization estimated that obesity caused at least 2.8 million deaths annually. On average, obesity reduces life expectancy by six to seven years,

4446-490: The benefits towards "healthier living" having physical benefits without dynamic shifts on the scales. Plus living with stigma surrounding the shape of one's body or actual treatments for the disease of obesity, be they medicinal or surgical, has been shown to greatly exacerbate the issue. Obesity increases a person's risk of developing various metabolic diseases, cardiovascular disease , osteoarthritis , Alzheimer disease , depression , and certain types of cancer. Depending on

4524-446: The body's response to insulin, potentially leading to insulin resistance . Increased fat also creates a proinflammatory state , and a prothrombotic state. Newer research has focused on methods of identifying healthier obese people by clinicians, and not treating obese people as a monolithic group. Obese people who do not experience medical complications from their obesity are sometimes called (metabolically) healthy obese , but

4602-587: The degree of obesity and the presence of comorbid disorders, obesity is associated with an estimated 2–20 year shorter life expectancy. High BMI is a marker of risk for, but not a direct cause of, diseases caused by diet and physical activity. Obesity is one of the leading preventable causes of death worldwide. The mortality risk is lowest at a BMI of 20–25 kg/m in non-smokers and at 24–27 kg/m in current smokers, with risk increasing along with changes in either direction. This appears to apply in at least four continents. Other research suggests that

4680-517: The dramatic increase seen within specific countries or globally. Though it is accepted that energy consumption in excess of energy expenditure leads to increases in body weight on an individual basis, the cause of the shifts in these two factors on the societal scale is much debated. There are a number of theories as to the cause but most believe it is a combination of various factors. The correlation between social class and BMI varies globally. Research in 1989 found that in developed countries women of

4758-517: The drive to eat. Dietary energy supply per capita varies markedly between different regions and countries. It has also changed significantly over time. From the early 1970s to the late 1990s the average food energy available per person per day (the amount of food bought) increased in all parts of the world except Eastern Europe. The United States had the highest availability with 3,654 calories (15,290 kJ) per person in 1996. This increased further in 2003 to 3,754 calories (15,710 kJ). During

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4836-482: The environment, increased phenotypic variance via assortative mating , social pressure to diet , among others. According to one study, factors like these may play as big of a role as excessive food energy intake and a lack of physical activity; however, the relative magnitudes of the effects of any proposed cause of obesity is varied and uncertain, as there is a general need for randomized controlled trials on humans before definitive statement can be made. According to

4914-493: The existence of metabolically healthy obesity—the metabolically healthy obese are often found to have low amounts of ectopic fat (fat stored in tissues other than adipose tissue) despite having overall fat mass equivalent in weight to obese people with metabolic syndrome . Although the negative health consequences of obesity in the general population are well supported by the available research evidence, health outcomes in certain subgroups seem to be improved at an increased BMI,

4992-667: The extent to which this group exists (especially among older people) is in dispute. The number of people considered metabolically healthy depends on the definition used, and there is no universally accepted definition. There are numerous obese people who have relatively few metabolic abnormalities, and a minority of obese people have no medical complications. The guidelines of the American Association of Clinical Endocrinologists call for physicians to use risk stratification with obese patients when considering how to assess their risk of developing type 2 diabetes. In 2014,

5070-471: The fact that people often lose weight as they become progressively more ill. Similar findings have been made in other types of heart disease. People with class I obesity and heart disease do not have greater rates of further heart problems than people of normal weight who also have heart disease. In people with greater degrees of obesity, however, the risk of further cardiovascular events is increased. Even after cardiac bypass surgery , no increase in mortality

5148-428: The great saphenous and small saphenous veins. There is some evidence that sclerotherapy is a safe and possibly effective treatment option for improving the cosmetic appearance, reducing residual varicose veins, improving the quality of life, and reducing symptoms that may be present due to the varicose veins. There is also weak evidence that this treatment option may have a slightly higher risk of deep vein thrombosis. It

5226-485: The late 1990s, Europeans had 3,394 calories (14,200 kJ) per person, in the developing areas of Asia there were 2,648 calories (11,080 kJ) per person, and in sub-Saharan Africa people had 2,176 calories (9,100 kJ) per person. Total food energy consumption has been found to be related to obesity. The widespread availability of dietary guidelines has done little to address the problems of overeating and poor dietary choice. From 1971 to 2000, obesity rates in

5304-701: The legs or ankles. Less commonly, but not exceptionally, varicose veins can be due to other causes, such as post-phlebitic obstruction or incontinence, venous and arteriovenous malformations. Venous reflux is a significant cause. Research has also shown the importance of pelvic vein reflux (PVR) in the development of varicose veins. Varicose veins in the legs could be due to ovarian vein reflux. Both ovarian and internal iliac vein reflux causes leg varicose veins. This condition affects 14% of women with varicose veins or 20% of women who have had vaginal delivery and have leg varicose veins. In addition, evidence suggests that failing to look for and treat pelvic vein reflux can be

5382-448: The main treatments recommended by health professionals. Diet quality can be improved by reducing the consumption of energy-dense foods, such as those high in fat or sugars, and by increasing the intake of dietary fiber , if these dietary choices are available, affordable, and accessible. Medications can be used, along with a suitable diet, to reduce appetite or decrease fat absorption. If diet, exercise, and medication are not effective,

5460-413: The metabolically healthy obese. Other definitions of metabolically healthy obesity exist, including ones based on waist circumference rather than BMI, which is unreliable in certain individuals. Another identification metric for health in obese people is calf strength , which is positively correlated with physical fitness in obese people. Body composition in general is hypothesized to help explain

5538-456: The saphenous main trunks, they are no longer available for use as venous bypass grafts in the future (coronary or leg artery vital disease). Other surgical treatments are: A commonly performed non-surgical treatment for varicose and "spider leg veins" is sclerotherapy , in which medicine called a sclerosant is injected into the veins to make them shrink. The medicines that are commonly used as sclerosants are polidocanol (POL branded Asclera in

5616-729: The second century BC, when Plutarch tells of such treatment performed on the Roman leader Gaius Marius. People with varicose veins might have a positive D-dimer blood test result due to chronic low-level thrombosis within dilated veins ( varices ). Most varicose veins are reasonably benign, but severe varicosities can lead to major complications, due to the poor circulation through the affected limb. Varicose veins are more common in women than in men and are linked with heredity . Other related factors are pregnancy , obesity , menopause , aging , prolonged standing, leg injury and abdominal straining. Varicose veins are unlikely to be caused by crossing

5694-493: The strongest is the link with type 2 diabetes . Excess body fat underlies 64% of cases of diabetes in men and 77% of cases in women. Health consequences fall into two broad categories: those attributable to the effects of increased fat mass (such as osteoarthritis , obstructive sleep apnea , social stigmatization) and those due to the increased number of fat cells ( diabetes , cancer , cardiovascular disease , non-alcoholic fatty liver disease ). Increases in body fat alter

5772-470: The time of endovenous treatment. This is also known as an ambulatory phlebectomy . The distal veins are removed following the complete ablation of the proximal vein. This treatment is most commonly used for varicose veins off of the great saphenous vein, small saphenous vein, and pudendal veins. Follow-up treatment to smaller branch varicose veins is often needed in the weeks or months after the initial procedure. Also called medical super glue, medical adhesive

5850-436: The treatment of varicose veins." It also found in its assessment of available literature, that "occurrence rates of more severe complications such as DVT, nerve injury, and paraesthesia, post-operative infections, and haematomas, appears to be greater after ligation and stripping than after EVLT". Complications for ELA include minor skin burns (0.4%) and temporary paresthesia (2.1%). The longest study of endovenous laser ablation

5928-471: The treatments, except that radiofrequency ablation could have a better long-term benefit. The National Institute for Health and Clinical Excellence (NICE) produced clinical guidelines in July 2013 recommending that all people with symptomatic varicose veins (C2S) and worse should be referred to a vascular service for treatment. Conservative treatments such as support stockings should not be used unless treatment

6006-426: Was injected. There are three kinds of endovenous thermal ablation treatment possible: laser, radiofrequency, and steam. The Australian Medical Services Advisory Committee (MSAC) in 2008 determined that endovenous laser treatment /ablation (ELA) for varicose veins "appears to be more effective in the short term, and at least as effective overall, as the comparative procedure of junction ligation and vein stripping for

6084-576: Was not possible. The symptoms of varicose veins can be controlled to an extent with the following: Stripping consists of removal of all or part the saphenous vein ( great/long or lesser/short ) main trunk. The complications include deep vein thrombosis (5.3%), pulmonary embolism (0.06%), and wound complications including infection (2.2%). There is evidence for the great saphenous vein regrowing after stripping. For traditional surgery, reported recurrence rates, which have been tracked for 10 years, range from 5% to 60%. In addition, since stripping removes

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