92-685: Xin Zhui ( Chinese : 辛追 ; [ɕín ʈʂwéɪ] ; c. 217 BC –169 or 168 BC), also known as Lady Dai or the Marquise of Dai , was a Chinese noblewoman. She was the wife of Li Cang ( 利蒼 ), the Marquis of Dai, and Chancellor of the Changsha Kingdom , during the Western Han dynasty of ancient China. Her tomb, containing her well-preserved remains and 1,400 artifacts,
184-812: A heart attack that caused her death. Along with schistosomiasis , a parasitic infection , she also had coronary thrombosis and arteriosclerosis , most likely linked to excessive weight gained due to a sedentary lifestyle , diabetes , angina pectoris , liver disease , and hypertension . Lumbago and a compressed spinal disc probably caused her immense pain, which contributed to a decrease in physical activity. She also suffered from gallstones , one of which lodged in her bile duct and further deteriorated her condition. Her arteries were found to be heavily congested, leading to congestive heart failure . A total of 130 melon seeds were found in Xin Zhui's stomach, intestines, and esophagus; researchers believed she consumed
276-634: A combination of 27 loci, including the ABO gene, identified individuals at increased risk for both incident and recurrent coronary artery disease events, as well as an enhanced clinical benefit from statin therapy. The study was based on a community cohort study (the Malmo Diet and Cancer study) and four additional randomized controlled trials of primary prevention cohorts (JUPITER and ASCOT) and secondary prevention cohorts (CARE and PROVE IT-TIMI 22). In April 2007, an international team of researchers announced in
368-443: A component—either a character or a sub-component called a radical —usually involves either a reduction in its total number of strokes , or an apparent streamlining of which strokes are chosen in what places—for example, the ⼓ ' WRAP ' radical used in the traditional character 沒 is simplified to ⼏ ' TABLE ' to form the simplified character 没 . By systematically simplifying radicals, large swaths of
460-434: A conversion table. While exercising such derivation, the following rules should be observed: Sample Derivations : The Series One List of Variant Characters reduces the number of total standard characters. First, amongst each set of variant characters sharing identical pronunciation and meaning, one character (usually the simplest in form) is elevated to the standard character set, and the rest are made obsolete. Then amongst
552-429: A definitive observation that blood serum of an individual would agglutinate with only those of certain individuals. Based on this he classified human blood into three groups, namely group A, group B, and group C. He defined that group A blood agglutinates with group B, but never with its own type. Similarly, group B blood agglutinates with group A. Group C blood is different in that it agglutinates with both A and B. This
644-407: A few revised forms, and was implemented for official use by China's State Council on 5 June 2013. In Chinese, simplified characters are referred to by their official name 简化字 ; jiǎnhuàzì , or colloquially as 简体字 ; jiǎntǐzì . The latter term refers broadly to all character variants featuring simplifications of character form or structure, a practice which has always been present as
736-454: A lavish burial with many artifacts. More than 1,400 precious artifacts were found with Xin Zhui's body including a wardrobe containing 100 silk garments, 182 pieces of expensive lacquerware, makeup and toiletries, ornate burial banners, medicinal products, and 162 carved wooden figurines representing servants and musicians. The fluid present in the coffin allowed Xin Zhui's body to remain in such well-preserved condition. The mysterious liquid she
828-610: A newly coined phono-semantic compound : Removing radicals Only retaining single radicals Replacing with ancient forms or variants : Adopting ancient vulgar variants : Readopting abandoned phonetic-loan characters : Copying and modifying another traditional character : Based on 132 characters and 14 components listed in Chart 2 of the Complete List , the 1,753 derived characters found in Chart 3 can be created by systematically simplifying components using Chart 2 as
920-573: A part of the Chinese writing system. The official name tends to refer to the specific, systematic set published by the Chinese government, which includes not only simplifications of individual characters, but also a substantial reduction in the total number of characters through the merger of formerly distinct forms. According to Chinese palaeographer Qiu Xigui , the broadest trend in the evolution of Chinese characters over their history has been simplification, both in graphical shape ( 字形 ; zìxíng ),
1012-456: A relative down-regulation of GTA and GTB occurs in oral carcinomas in association with tumor development. More recently, a genome wide association study (GWAS) has identified variants in the ABO locus associated with susceptibility to pancreatic cancer. In addition, another large GWAS study has associated ABO-histo blood groups as well as FUT2 secretor status with the presence in the intestinal microbiome of specific bacterial species. In this case
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#17327804631281104-532: A single parent. The distribution of the blood groups A, B, O and AB varies across the world according to the population. There are also variations in blood type distribution within human subpopulations. In the UK, the distribution of blood type frequencies through the population still shows some correlation to the distribution of placenames and to the successive invasions and migrations including Celts , Norsemen , Danes , Anglo-Saxons , and Normans who contributed
1196-474: A special dominance relationship: codominance , which means that type A and B parents can have an AB child. A couple with type A and type B can also have a type O child if they are both heterozygous ( I i and I i ). The cis-AB phenotype has a single enzyme that creates both A and B antigens. The resulting red blood cells do not usually express A or B antigen at the same level that would be expected on common group A 1 or B red blood cells, which can help solve
1288-469: A two-sentence footnote: The serum of healthy human beings not only agglutinates animal red cells, but also often those of human origin, from other individuals. It remains to be seen whether this appearance is related to inborn differences between individuals or it is the result of some damage of bacterial kind. This was the first evidence that blood variations exist in humans — it was believed that all humans have similar blood. The next year, in 1901, he made
1380-430: A type O child can be born to an AB parent—due to rare situations, such as Bombay phenotype and cis AB . The A blood type contains about 20 subgroups, of which A1 and A2 are the most common (over 99%). A1 makes up about 80% of all A-type blood, with A2 making up almost all of the rest. These two subgroups are not always interchangeable as far as transfusion is concerned, as some A2 individuals produce antibodies against
1472-635: Is a popular belief in Blood type personality theory , which claims that blood types predict or influence personality. This claim is not scientifically based, and there is scientific consensus that no such link exists; the scientific community considers it a pseudoscience and a superstition . The belief originated in the 1930s, when it was introduced as part of Japan's eugenics program. Its popularity faded following Japan's defeat in World War 2 and Japanese support for eugenics faltered, but it resurfaced in
1564-440: Is actually more complex than eliminated ones. An example is the character 搾 which is eliminated in favor of the variant form 榨 . The 扌 'HAND' with three strokes on the left of the eliminated 搾 is now seen as more complex, appearing as the ⽊ 'TREE' radical 木 , with four strokes, in the chosen variant 榨 . Not all characters standardised in the simplified set consist of fewer strokes. For instance,
1656-453: Is also expressed on the von Willebrand factor (vWF) glycoprotein , which participates in hemostasis (control of bleeding). In fact, having type O blood predisposes to bleeding, as 30% of the total genetic variation observed in plasma vWF is explained by the effect of the ABO blood group, and individuals with group O blood normally have significantly lower plasma levels of vWF (and Factor VIII ) than do non-O individuals. In addition, vWF
1748-535: Is degraded more rapidly due to the higher prevalence of blood group O with the Cys1584 variant of vWF (an amino acid polymorphism in VWF): the gene for ADAMTS13 (vWF-cleaving protease ) maps to human chromosome 9 band q34.2, the same locus as ABO blood type. Higher levels of vWF are more common amongst people who have had ischemic stroke (from blood clotting) for the first time. The results of this study found that
1840-454: Is derived. Merging homophonous characters: Adapting cursive shapes ( 草書楷化 ): Replacing a component with a simple arbitrary symbol (such as 又 and 乂 ): Omitting entire components : Omitting components, then applying further alterations : Structural changes that preserve the basic shape Replacing the phonetic component of phono-semantic compounds : Replacing an uncommon phonetic component : Replacing entirely with
1932-488: Is found worldwide, and likely predates human migration from Africa . The O01 allele is considered to predate the O02 allele. Some evolutionary biologists theorize that there are four main lineages of the ABO gene and that mutations creating type O have occurred at least three times in humans. From oldest to youngest, these lineages comprise the following alleles: A101/A201/O09 , B101 , O02 and O01 . The continued presence of
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#17327804631282024-432: Is named "enzyme converted to O" (ECO blood) but despite the early success of converting B- to O-type RBCs and clinical trials without adverse effects transfusing into A- and O-type patients, the technology has not yet become clinical practice. Another approach to the blood antigen problem is the manufacture of artificial blood , which could act as a substitute in emergencies. In Japan and other parts of East Asia, there
2116-813: Is now discouraged. A State Language Commission official cited "oversimplification" as the reason for restoring some characters. The language authority declared an open comment period until 31 August 2009, for feedback from the public. In 2013, the List of Commonly Used Standard Chinese Characters was published as a revision of the 1988 lists; it included a total of 8105 characters. It included 45 newly recognized standard characters that were previously considered variant forms, as well as official approval of 226 characters that had been simplified by analogy and had seen wide use but were not explicitly given in previous lists or documents. Singapore underwent three successive rounds of character simplification , eventually arriving at
2208-400: Is painted with a pattern of stylized clouds and with protective deities and auspicious animals roaming an empty universe. A tiny figure, the deceased woman, is emerging at the bottom center of the head end. Only her upper body is shown, indicating she is about to enter a new world. The third coffin exhibits a different color scheme and iconography. It is shining red, the color of immortality, and
2300-623: Is referred to as the " big seal script ". The traditional narrative, as also attested in the Shuowen Jiezi dictionary ( c. 100 AD ), is that the Qin small seal script that would later be imposed across China was originally derived from the Zhou big seal script with few modifications. However, the body of epigraphic evidence comparing the character forms used by scribes gives no indication of any real consolidation in character forms prior to
2392-547: Is used instead of 叠 in regions using traditional characters. The Chinese government stated that it wished to keep Chinese orthography stable. The Chart of Generally Utilized Characters of Modern Chinese was published in 1988 and included 7000 simplified and unsimplified characters. Of these, half were also included in the revised List of Commonly Used Characters in Modern Chinese , which specified 2500 common characters and 1000 less common characters. In 2009,
2484-431: The guqin , which was traditionally associated with refinement and intellect. As a noble, Xin Zhui also had access to a variety of imperial foods, including various types of meat, which were reserved for the royal family and members of the ruling class. Most of her clothing was made of silk and other valuable textiles, and she owned many cosmetics. As she aged, Xin Zhui suffered from many ailments that eventually led to
2576-481: The ABO gene that produce one's blood type: The same study also identified 18 rare alleles, which generally have a weaker glycosylation activity. People with weak alleles of A can sometimes express anti-A antibodies, though these are usually not clinically significant as they do not stably interact with the antigen at body temperature. Cis AB is another rare variant, in which A and B genes are transmitted together from
2668-653: The International Society of Blood Transfusions (ISBT) as of December 2022. A mismatch in this serotype (or in various others) can cause a potentially fatal adverse reaction after a transfusion, or an unwanted immune response to an organ transplant. Such mismatches are rare in modern medicine. The associated anti-A and anti-B antibodies are usually IgM antibodies, produced in the first years of life by sensitization to environmental substances such as food, bacteria, and viruses. The ABO blood types were discovered by Karl Landsteiner in 1901; he received
2760-854: The Nobel Prize in Physiology or Medicine in 1930 for this discovery. ABO blood types are also present in other primates such as apes , monkeys and Old World monkeys . The ABO blood types were first discovered by an Austrian physician, Karl Landsteiner , working at the Pathological-Anatomical Institute of the University of Vienna (now Medical University of Vienna ). In 1900, he found that red blood cells would clump together ( agglutinate ) when mixed in test tubes with sera from different persons, and that some human blood also agglutinated with animal blood. He wrote
2852-651: The Rockefeller Institute for Medical Research in New York. As a member of a committee of the National Research Council concerned with blood grouping, he suggested to substitute Janský's and Moss's systems with the letters O, A, B, and AB. (There was another confusion on the use of figure 0 for German null as introduced by Hirszfeld and von Dungern, because others used the letter O for ohne , meaning without or zero; Landsteiner chose
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2944-443: The morphemes to the placenames and the genes to the population. The native Celts tended to have more type O blood, while the other populations tended to have more type A. The two common O alleles, O01 and O02, share their first 261 nucleotides with the group A allele A01. However, unlike the group A allele, a guanosine base is subsequently deleted. A premature stop codon results from this frame-shift mutation . This variant
3036-419: The red blood cell antigens. The gene is located on the long arm of the ninth chromosome (9q34). The I allele gives type A, I gives type B, and i gives type O. As both I and I are dominant over i , only ii people have type O blood. Individuals with I I or I i have type A blood, and individuals with I I or I i have type B. I I people have both phenotypes , because A and B express
3128-456: The "Dot" stroke : The traditional components ⺥ and 爫 become ⺈ : The traditional component 奐 becomes 奂 : ABO blood group system The ABO blood group system is used to denote the presence of one, both, or neither of the A and B antigens on erythrocytes (red blood cells). For human blood transfusions , it is the most important of the 44 different blood type (or group) classification systems currently recognized by
3220-459: The "external appearances of individual graphs", and in graphical form ( 字体 ; 字體 ; zìtǐ ), "overall changes in the distinguishing features of graphic[al] shape and calligraphic style, [...] in most cases refer[ring] to rather obvious and rather substantial changes". The initiatives following the founding of the Qin dynasty (221–206 BC) to universalize the use of their small seal script across
3312-482: The 1986 General List of Simplified Chinese Characters , hereafter the General List . All characters simplified this way are enumerated in Chart 1 and Chart 2 in the 1986 Complete List . Characters in both charts are structurally simplified based on similar set of principles. They are separated into two charts to clearly mark those in Chart 2 as 'usable as simplified character components', based on which Chart 3
3404-520: The 1986 mainland China revisions. Unlike in mainland China, Singapore parents have the option of registering their children's names in traditional characters. Malaysia also promulgated a set of simplified characters in 1981, though completely identical to the mainland Chinese set. They are used in Chinese-language schools. All characters simplified this way are enumerated in Charts 1 and 2 of
3496-511: The 20th century was part of an initiative by the People's Republic of China (PRC) to promote literacy, and their use in ordinary circumstances on the mainland has been encouraged by the Chinese government since the 1950s. They are the official forms used in mainland China and Singapore , while traditional characters are officially used in Hong Kong , Macau , and Taiwan . Simplification of
3588-414: The A, B and O epitopes. Blood groups are inherited from both parents. The ABO blood type is controlled by a single gene (the ABO gene ) with three types of alleles inferred from classical genetics : i , I , and I . The I designation stands for isoagglutinogen , another term for antigen . The gene encodes a glycosyltransferase —that is, an enzyme that modifies the carbohydrate content of
3680-521: The A1 antigen. Complications can sometimes arise in rare cases when typing the blood. With the development of DNA sequencing , it has been possible to identify a much larger number of alleles at the ABO locus, each of which can be categorized as A, B, or O in terms of the reaction to transfusion, but which can be distinguished by variations in the DNA sequence. There are six common alleles in white individuals of
3772-548: The ABH substances were all attached to glycosphingolipids, Finne et al . (1978) found that the human erythrocyte glycoproteins contain polylactosamine chains that contains ABH substances attached and represent the majority of the antigens. The main glycoproteins carrying the ABH antigens were identified to be the Band 3 and Band 4.5 proteins and glycophorin. Later, Yamamoto's group showed the precise glycosyl transferase set that confers
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3864-470: The Chinese government published a major revision to the list which included a total of 8300 characters. No new simplifications were introduced. In addition, slight modifications to the orthography of 44 characters to fit traditional calligraphic rules were initially proposed, but were not implemented due to negative public response. Also, the practice of unrestricted simplification of rare and archaic characters by analogy using simplified radicals or components
3956-668: The First World War (1914–1915) when citric acid began to be used for blood clot prevention . Felix Bernstein demonstrated the correct blood group inheritance pattern of multiple alleles at one locus in 1924. Watkins and Morgan, in England, discovered that the ABO epitopes were conferred by sugars, to be specific, N-acetylgalactosamine for the A-type and galactose for the B-type. After much published literature claiming that
4048-660: The O alleles is hypothesized to be the result of balancing selection . Both theories contradict the previously held theory that type O blood evolved first. It is possible that food and environmental antigens (bacterial, viral, or plant antigens) have epitopes similar enough to A and B glycoprotein antigens. The antibodies created against these environmental antigens in the first years of life can cross-react with ABO-incompatible red blood cells that it comes in contact with during blood transfusion later in life. Anti-A antibodies are hypothesized to originate from immune response towards influenza virus , whose epitopes are similar enough to
4140-532: The Roman numerical I, II, III, and IV (corresponding to modern O, A, B, and AB). Unknown to Janský, an American physician William L. Moss devised a slightly different classification using the same numerical; his I, II, III, and IV corresponding to modern AB, A, B, and O. These two systems created confusion and potential danger in medical practice. Moss's system was adopted in Britain, France, and US, while Janský's
4232-554: The Western Han dynasty, elaborate and lavish burials were common practice; it was believed that another world, or afterlife , existed for the dead, and they needed food and accommodation just like the living. Therefore, these necessities in life should be brought into the grave for use in the afterlife. The coffin contained over 150 types of food and drink in total, including grains, vegetables, meats, pastries, and wine. The importance of filial piety during that time also resulted in
4324-512: The agglutinins which are present in the same serum. Thus, he discovered two antigens ( agglutinogens A and B) and two antibodies (agglutinins — anti-A and anti-B). His third group (C) indicated absence of both A and B antigens, but contains anti-A and anti-B. The following year, his students Adriano Sturli and Alfred von Decastello discovered the fourth type (but not naming it, and simply referred to it as "no particular type"). In 1910, Ludwik Hirszfeld and Emil Freiherr von Dungern introduced
4416-409: The association was with Bacteroides and Faecalibacterium spp . Bacteroides of the same OTU (operational taxonomic unit) have been shown to be associated with inflammatory bowel disease, thus the study suggests an important role for the ABO histo-blood group antigens as candidates for direct modulation of the human microbiome in health and disease. A multi-locus genetic risk score study based on
4508-414: The body and enter the heavens to become immortal. Xin Zhui's body was remarkably well preserved. Her skin was soft and moist, with muscles that still allowed for her arms and legs to flex at the joints. All her organs and blood vessels were also intact, with small amounts of Type A blood being found in her veins. There was hair on her head, with a wig pinned with a hair clasp on the back of her head. There
4600-428: The character set are altered. Some simplifications were based on popular cursive forms that embody graphic or phonetic simplifications of the traditional forms. In addition, variant characters with identical pronunciation and meaning were reduced to a single standardized character, usually the simplest among all variants in form. Finally, many characters were left untouched by simplification and are thus identical between
4692-407: The chosen variants, those that appear in the "Complete List of Simplified Characters" are also simplified in character structure accordingly. Some examples follow: Sample reduction of equivalent variants : Ancient variants with simple structure are preferred : Simpler vulgar forms are also chosen : The chosen variant was already simplified in Chart 1 : In some instances, the chosen variant
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#17327804631284784-432: The combinations obtained when one allele is taken from each parent; each has a 25% chance, but some occur more than once. The text above them summarizes the outcomes. Historically, ABO blood tests were used in paternity testing , but in 1957 only 50% of American men falsely accused were able to use them as evidence against paternity. Occasionally, the blood types of children are not consistent with expectations—for example,
4876-547: The contents of Xin Zhui's tomb revealed much information about life in the Han dynasty that was previously unknown. The discovery continues to advance the fields of archaeology and science in the 21st century, particularly in the area of preservation of ancient human remains. Scientists in 2003 developed a "secret compound" that was injected into Xin Zhui's still existing blood vessels to assure her preservation. Her funerary banner had Han dynasty religious art motifs on it. The woman on
4968-473: The country's writing system as a serious impediment to its modernization. In 1916, a multi-part English-language article entitled "The Problem of the Chinese Language" co-authored by the Chinese linguist Yuen Ren Chao (1892–1982) and poet Hu Shih (1891–1962) has been identified as a turning point in the history of the Chinese script—as it was one of the first clear calls for China to move away from
5060-442: The decorative motifs include divine animals and a winged immortal flanking three-peaked Mount Kunlun, which is a prime symbol of eternal happiness. Inside this tomb on top of the fourth and innermost coffin, the excavators found a painted silk banner about two meters long. Yellow and black feathers are stuck on the cover board of the coffin. The feathers stuck to the coffin were expressing the hopes that Xin Zhui would grow feathers on
5152-476: The early 20th century. In 1909, the educator and linguist Lufei Kui formally proposed the use of simplified characters in education for the first time. Over the following years—marked by the 1911 Xinhai Revolution that toppled the Qing dynasty , followed by growing social and political discontent that further erupted into the 1919 May Fourth Movement —many anti-imperialist intellectuals throughout China began to see
5244-634: The first official list of simplified forms was published, consisting of 324 characters collated by Peking University professor Qian Xuantong . However, fierce opposition within the KMT resulted in the list being rescinded in 1936. Work throughout the 1950s resulted in the 1956 promulgation of the Chinese Character Simplification Scheme , a draft of 515 simplified characters and 54 simplified components, whose simplifications would be present in most compound characters. Over
5336-463: The first round—but was massively unpopular and never saw consistent use. The second round of simplifications was ultimately retracted officially in 1986, well after they had largely ceased to be used due to their unpopularity and the confusion they caused. In August 2009, China began collecting public comments for a revised list of simplified characters; the resulting List of Commonly Used Standard Chinese Characters lists 8,105 characters, including
5428-475: The following decade, the Script Reform Committee deliberated on characters in the 1956 scheme, collecting public input regarding the recognizability of variants, and often approving forms in small batches. Parallel to simplification, there were also initiatives aimed at eliminating the use of characters entirely and replacing them with pinyin as an official Chinese alphabet, but this possibility
5520-511: The founding of the Qin. The Han dynasty (202 BC – 220 AD) that inherited the Qin administration coincided with the perfection of clerical script through the process of libian . Eastward spread of Western learning Though most closely associated with the People's Republic, the idea of a mass simplification of character forms first gained traction in China during
5612-622: The immune system from pathogens carrying antigens from other hosts. Thus, individuals possessing rare types are better equipped to detect pathogens. The high within-population diversity observed in human populations would, then, be a consequence of natural selection on individuals. The carbohydrate molecules on the surfaces of red blood cells have roles in cell membrane integrity, cell adhesion , membrane transportation of molecules, and acting as receptors for extracellular ligands, and enzymes. ABO antigens are found having similar roles on epithelial cells as well as red blood cells. The ABO antigen
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#17327804631285704-466: The increased usage of 朙 was followed by proliferation of a third variant: 眀 , with 目 'eye' on the left—likely derived as a contraction of 朙 . Ultimately, 明 became the character's standard form. The Book of Han (111 AD) describes an earlier attempt made by King Xuan of Zhou ( d. 782 BC ) to unify character forms across the states of ancient China , with his chief chronicler having "[written] fifteen chapters describing" what
5796-507: The journal Nature Biotechnology an inexpensive and efficient way to convert types A, B, and AB blood into type O. This is done by using glycosidase enzymes from specific bacteria to strip the blood group antigens from red blood cells . The removal of A and B antigens still does not address the problem of the Rh blood group antigen on the blood cells of Rh positive individuals, and so blood from Rh negative donors must be used. The modified blood
5888-630: The latter. ) This classification was adopted by the National Research Council and became variously known as the National Research Council classification, the International classification, and most popularly the "new" Landsteiner classification. The new system was gradually accepted and by the early 1950s, it was universally followed. The first practical use of blood typing in transfusion was by an American physician Reuben Ottenberg in 1907. Large-scale application began during
5980-465: The left, with the 月 'Moon' component on the right. Li Si ( d. 208 BC ), the Chancellor of Qin, attempted to universalize the Qin small seal script across China following the wars that had politically unified the country for the first time. Li prescribed the 朙 form of the word for 'bright', but some scribes ignored this and continued to write the character as 明 . However,
6072-417: The melon very quickly. From this, researchers inferred that she died in summer, when fruits and melons ripen. The presence of melon seeds in her stomach also indicates that she died within two to three hours of eating the fruit. Xin Zhui died at approximately 50 years of age in 169 or 168 BC. In 1968, workers digging an air raid shelter for a hospital near Changsha unearthed the tomb of Xin Zhui, as well as
6164-402: The most prominent Chinese authors of the 20th century, stated that "if Chinese characters are not destroyed, then China will die" ( 漢字不滅，中國必亡 ). During the 1930s and 1940s, discussions regarding simplification took place within the ruling Kuomintang (KMT) party. Many members of the Chinese intelligentsia maintained that simplification would increase literacy rates throughout the country. In 1935,
6256-551: The mother and child do not usually cause hemolytic disease of the newborn (HDN) because antibodies to the ABO blood groups are usually of the IgM type, which do not cross the placenta. However, in an O-type mother, IgG ABO antibodies are produced and the baby can potentially develop ABO hemolytic disease of the newborn . In human cells, the ABO alleles and their encoded glycosyltransferases have been described in several oncologic conditions. Using anti-GTA/GTB monoclonal antibodies, it
6348-553: The occurrence was not affected by ADAMTS13 polymorphism, and the only significant genetic factor was the person's blood group. ABO(H) blood group antigens are also carried by other hemostatically relevant glycoproteins, such as platelet glycoprotein Ibα, which is a ligand for vWF on platelets. The significance of ABO(H) antigen expression on these other hemostatic glycoproteins is not fully defined, but may also be relevant for bleeding and thrombosis. ABO blood group incompatibilities between
6440-497: The problem of an apparently genetically impossible blood group. Individuals with the rare Bombay phenotype (hh) produce antibodies against the A, B, and O groups and can only receive transfusions from other hh individuals. The table above summarizes the various blood groups that children may inherit from their parents. Genotypes are shown in the second column and in small print for the offspring: AO and AA both test as type A; BO and BB test as type B. The four possibilities represent
6532-430: The public and quickly fell out of official use. It was ultimately formally rescinded in 1986. The second-round simplifications were unpopular in large part because most of the forms were completely new, in contrast to the familiar variants comprising the majority of the first round. With the rescission of the second round, work toward further character simplification largely came to an end. In 1986, authorities retracted
6624-465: The recently conquered parts of the empire is generally seen as being the first real attempt at script reform in Chinese history. Before the 20th century, variation in character shape on the part of scribes, which would continue with the later invention of woodblock printing , was ubiquitous. For example, prior to the Qin dynasty (221–206 BC) the character meaning 'bright' was written as either 明 or 朙 —with either 日 'Sun' or 囧 'window' on
6716-597: The same conditions failed to preserve other bodies. Other " Mawangdui -Type" cadavers in similar conditions have been found in China. Two from the same time period as Xin Zhui; they belong to a male official named Sui Xiaoyuan [ zh ] found in Jingzhou and a noblewoman named Ling Huiping [ zh ] found in Lianyungang . No consistent pattern explained why their bodies were preserved. All three had coffins containing liquid. However, Lady Dai's
6808-481: The same set of simplified characters as mainland China. The first round was promulgated by the Ministry of Education in 1969, consisting of 498 simplified characters derived from 502 traditional characters. A second round of 2287 simplified characters was promulgated in 1974. The second set contained 49 differences from the mainland China system; these were removed in the final round in 1976. In 1993, Singapore adopted
6900-467: The second round completely, though they had been largely fallen out of use within a year of their initial introduction. That year, the authorities also promulgated a final version of the General List of Simplified Chinese Characters . It was identical to the 1964 list save for 6 changes—including the restoration of 3 characters that had been simplified in the first round: 叠 , 覆 , 像 ; the form 疊
6992-421: The term 0 (null) for the group Landsteiner designated as C, and AB for the type discovered by Adriano sturli and Alfred von decastello ( https://www.rockefeller.edu/our-scientists/karl-landsteiner/2554-nobel-prize/ ). They were also the first to explain the genetic inheritance of the blood groups. Czech serologist Jan Janský independently introduced blood type classification in 1907 in a local journal. He used
7084-410: The tomb of Xin Zhui, four coffins of decreasing sizes enclose one another. The first and outermost coffin is painted black, the color of death and the underworld. All painted images sealed inside this coffin were thus designed not for an outside viewer but for the deceased and concern the themes of death and rebirth, protection in the afterlife, and immortality. The second coffin has a black background but
7176-519: The tombs of her husband and a young man who is most commonly thought to be her son. With the assistance of over 1,500 local high school students, archaeologists began a large excavation of the site beginning in January 1972. Xin Zhui's body was found within four rectangular pine constructs that sat inside one another which were buried beneath layers of charcoal and white clay . The corpse was wrapped in twenty layers of clothing bound with silk ribbons. In
7268-479: The top is possibly Xin Zhui herself drawn in imitation of Nüwa or the snake-like spirits next to her who could have been inspired by Nüwa, in the process of becoming a xian . Simplified Chinese characters Simplified Chinese characters are one of two standardized character sets widely used to write the Chinese language , with the other being traditional characters . Their mass standardization during
7360-497: The traditional and simplified Chinese orthographies. The Chinese government has never officially announced the completion of the simplification process after the bulk of characters were introduced by the 1960s. In the wake of the Cultural Revolution , a second round of simplified characters was promulgated in 1977—largely composed of entirely new variants intended to artificially lower the stroke count, in contrast to
7452-833: The traditional character 強 , with 11 strokes is standardised as 强 , with 12 strokes, which is a variant character. Such characters do not constitute simplified characters. The new standardized character forms shown in the Characters for Publishing and revised through the Common Modern Characters list tend to adopt vulgar variant character forms. Since the new forms take vulgar variants, many characters now appear slightly simpler compared to old forms, and as such are often mistaken as structurally simplified characters. Some examples follow: The traditional component 釆 becomes 米 : The traditional component 囚 becomes 日 : The traditional "Break" stroke becomes
7544-522: The use of characters entirely. Instead, Chao proposed that the language be written with an alphabet, which he saw as more logical and efficient. The alphabetization and simplification campaigns would exist alongside one another among the Republican intelligentsia for the next several decades. Recent commentators have echoed some contemporary claims that Chinese characters were blamed for the economic problems in China during that time. Lu Xun , one of
7636-485: The α-D-N-galactosamine on the A glycoprotein to be able to elicit a cross-reaction. Anti-B antibodies are hypothesized to originate from antibodies produced against Gram-negative bacteria , such as E. coli , cross-reacting with the α-D-galactose on the B glycoprotein. However, it is more likely that the force driving evolution of allele diversity is simply negative frequency-dependent selection; cells with rare variants of membrane antigens are more easily distinguished by
7728-464: Was abandoned, confirmed by a speech given by Zhou Enlai in 1958. In 1965, the PRC published the List of Commonly Used Characters for Printing [ zh ] (hereafter Characters for Printing ), which included standard printed forms for 6196 characters, including all of the forms from the 1956 scheme. A second round of simplified characters was promulgated in 1977, but was poorly received by
7820-443: Was acidic, whereas others' were alkaline, which would have aided bacterial growth. The tombs were also dug to different depths, from 5 metres (16 feet) to 16 metres (52 feet) and contained differing amounts of charcoal and white clay. In addition, similar airtight and watertight coffins failed to keep other cadavers from decomposing into skeletons or dust. Besides having some of the best preserved human remains ever discovered in China,
7912-436: Was demonstrated that a loss of these enzymes was correlated to malignant bladder and oral epithelia. Furthermore, the expression of ABO blood group antigens in normal human tissues is dependent the type of differentiation of the epithelium. In most human carcinomas, including oral carcinoma, a significant event as part of the underlying mechanism is decreased expression of the A and B antigens. Several studies have observed that
8004-657: Was discovered in 1971 at Mawangdui , Changsha , Hunan, China. Her body and belongings are currently under the care of the Hunan Museum ; artifacts from her tomb were displayed in Santa Barbara and New York City in 2009. Her body is notable as being one of the most well preserved mummies ever found. Xin Zhui is thought to have lived a wealthy lifestyle. She had private musicians for entertainment who would play for her parties as well as for her personal amusement. She may have enjoyed playing music as well, particularly
8096-673: Was preferred in most European countries and some parts of US. To resolve the chaos, the American Association of Immunologists , the Society of American Bacteriologists , and the Association of Pathologists and Bacteriologists made a joint recommendation in 1921 that the Jansky classification be adopted based on priority. But it was not followed particularly where Moss's system had been used. In 1927, Landsteiner had moved to
8188-515: Was skin on her face, and her eyelashes and nose hair remained intact. The tympanic membrane of her left ear was also intact, and her finger and toe prints were distinct. This preservation allowed doctors at Hunan Provincial Medical Institute to perform an autopsy on 14 December 1972. Much of what is known about Xin Zhui's lifestyle was derived from this and other examinations. As a member of the nobility, her body would have been washed with fragrant water and wine, which has antibacterial properties. In
8280-525: Was soaked in was acidic, which may have worked to preserve the body by preventing bacteria from growing. Tests revealed it to also contain salt and magnesium. Many scientists believe that the fluid stemmed from the body, rather than liquid poured into the coffin. When the autopsy on Xin Zhui's remains was done, contact with the fluid caused a rash on the hands of the scientists conducting it. The rash persisted on their skin for three months. Scientists believe that three major factors helped preserve her body. First
8372-447: Was the careful preparation of the body for burial, which slowed early stage of decomposition. Second, the body was placed in an airtight set of coffins. Lastly, the burial chamber was positioned deep underground, surrounded by charcoal and white clay. Water and air did not leak in and the temperature stayed constantly cool. However, scientists do not know for certain what combination of factors helped preserve Xin Zhui's corpse, or why almost
8464-525: Was the discovery of blood groups for which Landsteiner was awarded the Nobel Prize in Physiology or Medicine in 1930. In his paper, he referred to the specific blood group interactions as isoagglutination, and also introduced the concept of agglutinins (antibodies), which is the actual basis of antigen-antibody reaction in the ABO system. He asserted: [It] may be said that there exist at least two different types of agglutinins, one in A, another one in B, and both together in C. The red blood cells are inert to
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