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44-989: [REDACTED] Look up cma in Wiktionary, the free dictionary. CMA may stand for: Accounting [ edit ] Certified Management Accountant Cost And Management Accountant (India) Chartered market analyst, designation of the American Academy of Financial Management Comparative market analysis , in real estate Institute of Certified Management Accountants of Sri Lanka or CMA Sri Lanka Associations [ edit ] California Medical Association , US Canadian Malayalee Association Canadian Medical Association Canadian Motorcycle Association Canadian Museums Association Catholic Medical Association Chess'n Math Association China Meteorological Administration Chinese Musicians' Association Chinese Muslim Association ,

88-878: A Canadian census area Chennai Metropolitan Area , India China Meteorological Administration Common Monetary Area Competition and Markets Authority , a regulatory body in the United Kingdom Computer Misuse Act 1990 Council for Multicultural Australia, former name of the Australian Multicultural Council Science [ edit ] Biology [ edit ] Chaperone-mediated autophagy Chemistry [ edit ] Calcium magnesium acetate , an inorganic compound Chloromethamphetamine Complex metallic alloys Other science [ edit ] Canis Major , astronomical constellation abbreviation "CMa" CMA (AAMA) ,

132-784: A certified medical assistant in the US Covariance Matrix Adaptation Evolution Strategy ( CMA-ES ) Critical medical anthropology Transportation [ edit ] Central Mountain Air , an airline based in Smithers, British Columbia, Canada Compagnie des Messageries Aériennes , a French airline Compañía Mexicana de Aviación , a Mexican airline Cunnamulla Airport (IATA airport code CMA ), Queensland, Australia Camarillo Airport (FAA lid code CMA ), California, USA CMA CGM Compact Modular Architecture platform ,

176-1007: A modular car platform developed by Geely Congestion management agency , a type of county-level agency in California Other uses [ edit ] Calculated Match Average , motorcycle speedway handicap CMA (AAMA) , medical assistant credential Clearwater Marine Aquarium Cleveland Museum of Art Columbus Museum of Art Country Music Association Awards (CMA Awards or CMAs) Cumbria , ceremonial county in England Ćma , 1980 Polish film, The Moth in English Koho language (ISO 639 language code cma ) See also [ edit ] [REDACTED] Search for "cma"  or "c-m-a" on Misplaced Pages. All pages with titles beginning with CMA All pages with titles containing CMA CMAS (disambiguation) Topics referred to by

220-416: A protein to be a CMA substrate, it must have in its amino acid sequence a pentapeptide motif biochemically related to KFERQ. This CMA-targeting motif is recognized by a cytosolic chaperone, heat shock cognate protein of 70 kDa (hsc70) which targets the substrate to the lysosome surface. This substrate protein-chaperone complex binds to lysosome-associated membrane protein type 2A (LAMP-2A), which acts as

264-1046: A religious organization in Taiwan Christian Ministers' Association Christian and Missionary Alliance Christian Motorcyclists Association Community Media Association Constitutional Monarchy Association, a formation of the International Monarchist League Country Music Association Council of Magickal Arts Crystal Meth Anonymous Cumberland Miners' Association Colleges and schools [ edit ] Camden Military Academy , South Carolina, US Columbia Military Academy , Tennessee, US California State University Maritime Academy , Vallejo, California, US Government [ edit ] Capital Market Authority (disambiguation) : regulatory bodies in various countries Catchment Management Authority (disambiguation) , Australia Census metropolitan area ,

308-469: A rigorous exam, meet an educational requirement, experience requirement, and demonstrate a commitment to continuous learning through continuing professional education (CPE) . Prior to 2010, the CMA exam was organized into four parts: Business Analysis, Management Accounting and Reporting, Strategic Management and Decision Analysis. Since 2010, the exam has been condensed into two four-hour parts, covering largely

352-471: A role for CMA in stem cell function. CMA activity is upregulated during differentiation of embryonic stem cells and contributed to the degradation of IDH1 and Plin2. CMA activity has been shown to be modulated through retinoic acid receptor alpha signaling and is specifically activated by designed all-trans retinoic acid derivatives in cultured cells. CMA is also responsible for the selective removal of damaged and no-longer-functional proteins. This function

396-535: A university degree in accounting or finance; or an MBA, or a recognised professional qualification in accounting/finance. Those not meeting these entry criteria need to complete the Graduate Management Accountant (GMA) or GMA Conversion program first. Those undertaking course at an ICMA Recognised Provider Institution are all examined by the ICMA: [A student must obtain a 50% pass grade, in

440-504: Is activated during T cell activation due to increased expression of the CMA receptor LAMP-2A. CMA is essential for T cell activation through the degradation of negative regulators of T cell activation (Itch, RCAN1). Consequently, specific depletion of CMA in T cells results in immune response deficiency following immunization or infection. CMA is increased upon genotoxic stress . Conversely, decreased CMA activity associates with increased genome instability and decreased cell survival. CMA

484-433: Is an Australian organisation operating globally, focused on management accounting. A management accountant applies his or her professional knowledge and skill in the preparation and presentation of financial and other decision-oriented information in such a way as to assist management in the formulation of policies and in the planning and control of the operation of the undertaking. Management Accountants therefore are seen as

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528-568: Is committed to scholarship and quality education at the lowest possible cost to its students. The educational objectives of the Institute of Certified Management Accountants (ICMA) are therefore to further the development of management accounting education in the universities and business schools of Australia and Internationally, to encourage research into the application of management accounting theory and practice, and to provide continuing professional development for its members. In order to achieve

572-450: Is critical when cells are exposed to agents that cause protein damage as the selectivity of CMA ensures that only the damaged proteins get targeted to lysosomes for degradation. For instance, oxidative stress and exposure to toxic compounds are stimuli that upregulate CMA. Consequently, cells that are defective for CMA are more susceptible to these insults than control cells. CMA performs various specialized functions as well, depending on

616-406: Is designed as the first post-graduate level management accounting qualification in the world. There are other unique aspects to ICMA's Education program. It was the first professional body in the world to embed its CMA subjects within master's degree programs in accredited universities; and allow those universities to examine students internally. The CMA Preparatory Program is only open to those with

660-701: Is different from Wikidata All article disambiguation pages All disambiguation pages Certified Management Accountant Since the Canadian body merged with the CPA Canada in September 2015, there are only 2 global bodies that offer the CMA certification, IMA (USA) and ICMA (Australia). However, the certification pathways for the two bodies – in terms of entry requirements, study syllabi and experience requirements are very different. The United States –based Institute of Management Accountants USA

704-401: Is eligible to join as an Associate Management Accountant (AMA). Such students can enrol for the post-graduate level CMA program at any time; but must successfully complete this program and also accumulate 5-years of business experience to be eligible to join as a Certified Management Accountant (CMA). The flagship CMA Preparatory Program consists of two subjects: The CMA program from Australia

748-530: Is involved in the removal of Chk1, a key protein for cell cycle progression and cells with impaired CMA have defective DNA repair. CMA degrades lipid droplet proteins ( perilipin 2 and perilipin 3 ). Removal of these lipid droplet coat proteins by CMA precedes lipolysis and lipophagy. Consequently, defective CMA activity leads to massive accumulation of lipid droplets and steatosis. CMA activity declines with age in many cell types of old rodents and in cells of older humans. This impairment of CMA in aging

792-399: Is limited, the cells respond by activating autophagy, in order to degrade intracellular components to provide energy and building blocks, which the cell can utilize in this dire state. Macroautophagy is activated as early as 30 minutes into starvation and remains at high activity for at least 4–8 hours into starvation. If the starvation state persists for more than 10 hours, the cells switch to

836-407: Is mainly due to a decrease in the levels of LAMP-2A at the lysosomal membrane, because of reduced stability of the CMA receptor and not due to decreased de novo synthesis. Studies in a transgenic mouse model in which normal levels of LAMP-2A are maintained throughout life, showed that these animals had ‘cleaner’ cells, better response to stress – and overall, a better health-span. These studies support

880-550: Is one of the two global bodies that offers the CMA Certification. Only authorized partners of IMA can provide coaching to students for CMA USA. CMA (USA)-certified professionals work inside organizations of all sizes, industries, and types, including manufacturing and services, public and private enterprises, not-for-profit organizations, academic institutions, Government entities (USA), and multinational corporations worldwide. To obtain certification, candidates must pass

924-513: The "value-creators" amongst the accountants. They are much more interested in forward looking and taking decisions that will affect the future of the organization, than in the historical recording and compliance (scorekeeping) aspects of the profession. Management accounting knowledge and experience can therefore be obtained from varied fields and functions within an organization, such as information management, treasury, efficiency auditing, marketing, valuation, pricing, logistics, etc. ICMA (Australia)

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968-607: The CMA exam are scored on a scale of 0–500 with a candidate's raw score converted to a uniform scaled score against all exam candidates. On this scale, a score of 360 represents the minimum passing scaled score. Part 1 – Financial Planning, Performance, and Analytics. Part 2 – Strategic Financial Management In addition to successfully passing the exams, CMA candidates must fulfill education and experience requirements in order to be certified: 1. Bachelor's degree from an accredited college or university 2. Two continuous years of professional experience employing

1012-496: The Technician-level program and can advance directly to the CMA program. Those holding a non-accounting/finance degree or professional qualification need to undertake a Graduate Conversion program (Stage 4) prior to undertaking the CMA program Students who have obtained a non-accounting degree, or are full members of recognized professional non-accounting bodies (e.g., Chartered Institute of Marketing) would have satisfied

1056-598: The above objectives, the following educational programmes have been implemented by the institute. These programmes cover the three technician-level qualifications of ICMA: There are 4-Stages in the Technician-Level Programs, consisting of 4-Subjects each as follows: These programmes cover the professional-level qualifications of ICMA These certifications are only open to degree holders. Those holding an accounting/finance degree (or equivalent professional qualification) are exempt from all four stages of

1100-467: The best-characterized CMA substrates are enzymes involved in glycolysis, a pathway known to be less active in fasting conditions. CMA is important in regulating cellular metabolism . Specific depletion of CMA in liver results in robust hepatic glycogen use accompanied with accumulation of fat in the liver, along with altered glucose homeostasis, increased energy expenditure and reduced peripheral adiposity. Proteomics analyses identified several enzymes of

1144-527: The broad educational objectives to enrol in the Graduate Conversion programme -which is to complete Stage 4 of the GMA programme prior to undertaking the CMA program. A student completing the Graduate Conversion programme is eligible to join as a Graduate Management Accountant (GMA). A student completing the Graduate Management Accountant (GMA) program and having 3 years or more of business experience

1188-470: The carbohydrate and the lipid metabolism pathways to be CMA substrates, and their altered degradation in the knockout mice explaining the abnormal metabolic phenotype of the CMA-deficient mice. The ability of CMA to selectively degrade enzymes involved in the metabolism of free fatty acids (i.e. linoleic and linolic pathway) has proven key for activation of hematopoietic stem cells , thus supporting

1232-521: The cytosol. Therefore, some of the components that participate in CMA are present in the cytosol while others are located at the lysosomal membrane ( Table I ). Specific selection of proteins for degradation in all forms of autophagy came to further understanding as studies discovered the role of chaperones like hsc70. Although hsc70 targets cytosolic protein to CMA based on specific amino acid sequence recognition, it works differently when targeting proteins to macro or microautophagy. In one mechanism for

1276-593: The defect lies in the ‘tight’ binding to the lysosomal membrane of pathogenic proteins known to accumulate in these disorders (α-synuclein, UCHL1 in Parkinson’s disease and mutant Tau in tauopathies). These toxic proteins often bind to LAMP-2A with abnormal affinity exerting a ‘clogging effect’ at the lysosomal membrane and thus, inhibit the CMA-mediated degradation of other cytosolic substrate proteins. Links between CMA and cancer have also been established. CMA

1320-459: The degradation rates of LAMP-2A monomers in lysosomes and by de novo synthesis of LAMP-2A molecules. In addition, transport of substrates also depends on the efficiency of the assembly of LAMP-2A into the translocation complex. Assembly and disassembly of CMA translocation complex is mediated by hsp90 and hsc70 chaperones, respectively. Degradation of LAMP-2A monomers at the lysosomal membrane occurs in discrete cholesterol-rich lipid microdomains of

1364-412: The degraded proteins (contribution to energetic cellular balance ) and by eliminating abnormal or damaged proteins (contribution to cellular quality control ). CMA is active at all times in different tissues (liver, kidney, brain), and almost all cell types in culture studied. However, it is maximally activated in response to stressors and changes in the cellular nutritional status. When nutrient supply

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1408-498: The final assessment to pass the subject. Students obtaining less than 50% in the final assessment would Fail the subject.] In addition to passing the two subjects, one needs to have 5-years of business experience to qualify as a Certified Management Accountant (CMA). Chaperone-mediated autophagy Chaperone-mediated autophagy ( CMA ) refers to the chaperone-dependent selection of soluble cytosolic proteins that are then targeted to lysosomes and directly translocated across

1452-464: The lysosomal membrane and it is mediated by Cathepsin A and an unidentified lysosomal metalloprotease. Therefore, assembly, disassembly of LAMP-2A into active translocation complex, and its degradation in microdomain regions, highlights the dynamic nature of this process and the importance of lateral mobility of the CMA receptor at the lysosomal membrane. CMA contributes to the maintenance of cellular homeostasis by facilitating recycling of amino acids of

1496-502: The lysosomal membrane. This binding of substrates to monomers of LAMP-2A triggers the assembly of LAMP-2A multimers that act as the active translocation complex through which the substrates can pass through after unfolding. Here, the translocation complex chooses only the substrate proteins which can unfold for internalization by the lysosomes. For instance, research with artificial CMA substrate showed that hsc70 chaperone binding to substrate or lysosomal binding does not necessarily require

1540-419: The lysosomal proteases. Figure 1 depicts the different steps of CMA. The limiting step for CMA is the binding of the substrate proteins to LAMP-2A and, consequently, levels of LAMP-2A at the lysosomal membrane correlate directly with CMA activity. Therefore, to modulate the activity of this autophagic pathway, the cell stringently regulates the levels of the CMA receptor at the lysosomal membrane by controlling

1584-432: The lysosome membrane for degradation. The unique features of this type of autophagy are the selectivity on the proteins that are degraded by this pathway and the direct shuttling of these proteins across the lysosomal membrane without the requirement for the formation of additional vesicles ( Figure 1 ). The proteins that are degraded through CMA are cytosolic proteins or proteins from other compartments once they reach

1628-573: The possible contribution of declined CMA activity to poor cellular homeostasis and inefficient response to stress characteristic of old organisms. High-fat diet inhibits CMA. This is because of a decrease in the stability of the CMA receptor at the lysosomal surface. More recently CMA has been implicated in the regeneration capacity of new blood cells by sustaining hematopoietic stem cell function. A primary defect in CMA activity has also been described in neurodegenerative diseases , such as Parkinson’s disease and certain tauopathies. In these cases,

1672-438: The principles of management accounting and financial management including: 3. For certified CMAs, 30 hours of CPE credits, including two hours of ethics, and annual IMA Membership are required to maintain active status. In September 2021, IMA announced the historic milestone of awarding 100,000 CMA certifications. IMA awards 100,000th CMA certification to Qatar's Parkar The Institute of Certified Management Accountants (ICMA)

1716-439: The receptor for this pathway. LAMP-2A a single span membrane protein, is one of the three spliced variants of a single gene lamp2 . The other two isoforms LAMP-2B and LAMP-2C are involved in macroautophagy and vesicular trafficking, respectively. Substrate proteins undergo unfolding after binding to LAMP-2A in a process likely mediated by the membrane associated hsc70 and its co-chaperones Bag1, hip, hop and hsp40, also detected at

1760-419: The same material as the former four part exam with added emphasis on financial planning, analysis, control, and decision support. Each exam consists of descriptive questions and two 30-minute essay questions. Candidates are given 3 hours to complete the multiple choice section and one hour to complete the essays. Candidates must show their work for the essay questions in order to receive credit. Parts 1 and 2 of

1804-403: The same term [REDACTED] This disambiguation page lists articles associated with the title CMA . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=CMA&oldid=1225102082 " Category : Disambiguation pages Hidden categories: Short description

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1848-421: The selective form of autophagy, namely CMA, which is known to reach a plateau of maximal activation ~36 hours into fasting and remains at these levels until ~3 days. The selectivity of CMA for individual cytosolic proteins permits cells to degrade only those proteins that might not be required in these starvation conditions in order to generate amino acids for the synthesis of essential proteins. For example, some of

1892-400: The specific protein undergoing degradation through this pathway and the cell type involved. For example, known CMA substrates include, MEF2D, a neuronal factor important for survival; Pax2, a transcription factor, important for the regulation growth of renal tubular cells; IκBα, known inhibitor of NFκB. CMA has also been suggested to contribute to antigen presentation in dendritic cells. CMA

1936-406: The substrate protein to be capable of unfolding, however, lysosomal translocation makes unfolding as a necessary criteria for it to be internalized. Substrate translocation requires the presence of hsc70 inside the lysosomal lumen, which may act by either pulling substrates into the lysosomes or preventing their return to the cytosol. After translocation the substrate proteins are rapidly degraded by

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