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Copenhagen General Population Study

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The Copenhagen General Population Study ( CGPS ; Danish : Herlev/Østerbroundersøgelsen ) is an ongoing Danish longitudinal cohort study , that investigates the epidemiology of a wide range of diseases , in particular cardiovascular disease , respiratory disease , cancer , infections and other multifactorial diseases , in a representative sample of the Danish population . Headquartered at the Department of Clinical Biochemistry at Herlev Hospital , it was established in 2003 with professor Børge Nordestgaard as principal investigator , and it is the world's largest population study that follows the long-term health development of a healthy population over time, currently collecting data on over 170,000 enrolled participants .

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60-544: Expanding upon the earlier and less extensive sister study, the Copenhagen City Heart Study (CCHS; Danish : Østerbroundersøgelsen ), the population survey has been conducted in several phases since 1976, incipiently involving a representative sample of people in the Østerbro neighbourhood of Copenhagen . In 2003, the CGPS was established to expand the study to cover an increasingly large area in

120-429: A "difficult language to learn, acquire and understand", and some evidence shows that children are slower to acquire the phonological distinctions of Danish compared with other languages. The grammar is moderately inflective with strong (irregular) and weak (regular) conjugations and inflections. Nouns, adjectives, and demonstrative pronouns distinguish common and neutral gender. Like English, Danish only has remnants of

180-577: A former case system , particularly in the pronouns. Unlike English, it has lost all person marking on verbs. Its word order is V2 , with the finite verb always occupying the second slot in the sentence. Danish is a Germanic language of the North Germanic branch . Other names for this group are the Nordic or Scandinavian languages. Along with Swedish, Danish descends from the Eastern dialects of

240-505: A large cardiovascular -focused study. Although designed with a large emphasis on cardiovascular disease , specifically coronary heart disease and stroke , it quickly expanded to include a wide array of health conditions, such as pulmonary diseases , heart failure , arrhythmia , dementia , and various genetic and psychosocial factors. The initial study population of the Copenhagen City Heart Study consisted of

300-526: A literary language. Also in this period, Danish began to take on the linguistic traits that differentiate it from Swedish and Norwegian, such as the stød , the voicing of many stop consonants, and the weakening of many final vowels to /e/. The first printed book in Danish dates from 1495, the Rimkrøniken ( Rhyming Chronicle ), a history book told in rhymed verses. The first complete translation of

360-707: A number of Danes remained as a minority within German territories . After the occupation of Denmark by Germany in World War II, the 1948 orthography reform dropped the German-influenced rule of capitalizing nouns, and introduced the letter ⟨å⟩ . Three 20th-century Danish authors have become Nobel Prize laureates in Literature : Karl Gjellerup and Henrik Pontoppidan (joint recipients in 1917) and Johannes V. Jensen (awarded 1944). With

420-562: A random sample of nearly 20,000 men and women, aged 20 to 93, selected from approximately 90,000 residents aged 20 and older in ten wards around Rigshospitalet in Copenhagen , encompassing all of Østerbro and one-third of Nørrebro , districts of Copenhagen Municipality . The Copenhagen General Population Study (CGPS) was established on 26 November 2003 at Herlev Hospital under the leadership of Professor Børge Nordestgaard . Designed as an expansion of this precursor study, it broadened

480-482: A similarity in pronunciation, combined with the long tradition of having Danish as a written language, which has led to similarities in vocabulary. Among younger Danes, Copenhageners are worse at understanding Swedish than Danes from the provinces. In general, younger Danes are not as good at understanding the neighboring languages as the young in Norway and Sweden. The Danish philologist Johannes Brøndum-Nielsen divided

540-586: A so-called multiethnolect in the urban areas, an immigrant Danish variety (also known as Perkerdansk ), combining elements of different immigrant languages such as Arabic, Turkish, and Kurdish, as well as English and Danish. Within the Danish Realm , Danish is the national language of Denmark and one of two official languages of the Faroe Islands (alongside Faroese ). There is a Faroese variant of Danish known as Gøtudanskt . Until 2009, Danish

600-625: A variant of Standard Danish, Southern Schleswig Danish , is spoken in the area. Since 2015, Schleswig-Holstein has officially recognized Danish as a regional language , just as German is north of the border. Furthermore, Danish is one of the official languages of the European Union and one of the working languages of the Nordic Council . Under the Nordic Language Convention , Danish-speaking citizens of

660-407: A very large vowel inventory consisting of 27 phonemically distinctive vowels , and its prosody is characterized by the distinctive phenomenon stød , a kind of laryngeal phonation type . Due to the many pronunciation differences that set Danish apart from its neighboring languages, particularly the vowels, difficult prosody and "weakly" pronounced consonants, it is sometimes considered to be

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720-571: Is a North Germanic language from the Indo-European language family spoken by about six million people, principally in and around Denmark . Communities of Danish speakers are also found in Greenland , the Faroe Islands , and the northern German region of Southern Schleswig , where it has minority language status. Minor Danish-speaking communities are also found in Norway , Sweden ,

780-700: Is a West Germanic language descended from Old English. Old Norse exerted a strong influence on Old English in the early medieval period. The shared Germanic heritage of Danish and English is demonstrated with many common words that are very similar in the two languages. For example, when written, commonly used Danish verbs, nouns, and prepositions such as have , over , under , for , give , flag , salt , and arm are easily recognizable to English speakers. Similarly, some other words are almost identical to their Scots equivalents, e.g. kirke (Scots kirk , i.e., 'church') or barn (Scots and northern English bairn , i.e. 'child'). In addition,

840-430: Is its closest relative. East Germanic languages West Germanic languages Icelandic Faroese Norwegian Danish Swedish Approximately 2,000 uncompounded Danish words are derived from Old Norse and ultimately from Proto Indo-European . Of these 2,000, 1,200 are nouns, 500 are verbs and 180 are adjectives. Danish has also absorbed many loanwords , most of which were borrowed from Low German of

900-1099: Is strongly linked to higher risks of all-cause mortality , including deaths from cardiovascular diseases and cancer. These discoveries underscore the CGPS's broad impact on understanding the interplay of lifestyle, genetics, and metabolic factors in health outcomes. Laugesen, Kristina; Mengel-From, Jonas; Christensen, Kaare; Olsen, Jørn; Hougaard, David M.; Boding, Lasse; Olsen, Anja; Erikstrup, Christian; Hetland, Merete Lund; Høgdall, Estrid; Kjaergaard, Alisa D.; Sørensen, Erik; Brügmann, Anja; Petersen, Eva Rabing Brix; Brandslund, Ivan (2023). "A Review of Major Danish Biobanks: Advantages and Possibilities of Health Research in Denmark" . Clinical Epidemiology . 15 : 213–239. doi : 10.2147/CLEP.S392416 . ISSN   1179-1349 . PMC   9960719 . PMID   36852012 . Danish language Nordic Council Danish ( / ˈ d eɪ n ɪ ʃ / , DAY -nish ; endonym : dansk pronounced [ˈtænˀsk] , dansk sprog [ˈtænˀsk ˈspʁɔwˀ] )

960-436: The skarre-R , the uvular R sound ( [ʁ] ), began spreading through Denmark, likely through influence from Parisian French and German. It affected all of the areas where Danish had been influential, including all of Denmark, Southern Sweden, and coastal southern Norway. In the 18th century, Danish philology was advanced by Rasmus Rask , who pioneered the disciplines of comparative and historical linguistics, and wrote

1020-568: The Bible in Danish, the Bible of Christian II translated by Christiern Pedersen , was published in 1550. Pedersen's orthographic choices set the de facto standard for subsequent writing in Danish. From around 1500, several printing presses were in operation in Denmark publishing in Danish and other languages. In the period after 1550, presses in Copenhagen dominated the publication of material in

1080-703: The Copenhagen metropolitan area . A second phase is currently in progress for the study, whereas a sixth is underway under the auspices of CCHS. All participants are recalled for follow-up examinations, and are followed in the Danish Civil Registration System and medical records . The survey includes a comprehensive physical examination , preceded by a questionnaire on lifestyle factors . The examination covers heart and lung function , measurements of height, weight, blood pressure , ankle-brachial pressure index , extensive blood sample analysis and other clinical examinations. Since 1976,

1140-570: The Late Middle Ages . Out of the 500 most frequently used Danish words, 100 are loans from Middle Low German; this is because Low German was the second official language of Denmark–Norway. In the 17th and 18th centuries, standard German and French superseded Low German influence, and in the 20th century, English became the main supplier of loanwords, especially after World War II . Although many old Nordic words remain, some were replaced with borrowed synonyms, for example æde (to eat)

1200-523: The Old Norse language ; Danish and Swedish are also classified as East Scandinavian or East Nordic languages. Scandinavian languages are often considered a dialect continuum , where no sharp dividing lines are seen between the different vernacular languages. Like Norwegian and Swedish, Danish was significantly influenced by Low German in the Middle Ages, and has been influenced by English since

1260-1091: The United States , Canada , Brazil , and Argentina . Along with the other North Germanic languages, Danish is a descendant of Old Norse , the common language of the Germanic peoples who lived in Scandinavia during the Viking Era . Danish, together with Swedish, derives from the East Norse dialect group , while the Middle Norwegian language (before the influence of Danish) and Norwegian Bokmål are classified as West Norse along with Faroese and Icelandic . A more recent classification based on mutual intelligibility separates modern spoken Danish, Norwegian , and Swedish as "mainland (or continental ) Scandinavian", while Icelandic and Faroese are classified as "insular Scandinavian". Although

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1320-544: The Zealand dialect Introductio ad lingvam Danicam puta selandicam ; and in 1685 the first Danish grammar written in Danish, Den Danske Sprog-Kunst ("The Art of the Danish Language") by Peder Syv . Major authors from this period are Thomas Kingo , poet and psalmist, and Leonora Christina Ulfeldt , whose novel Jammersminde ( Remembered Woes ) is considered a literary masterpiece by scholars. Orthography

1380-402: The introduction of the printing press , a standard language was developed which was based on the educated dialect of Copenhagen and Malmö . It spread through use in the education system and administration, though German and Latin continued to be the most important written languages well into the 17th century. Following the loss of territory to Germany and Sweden, a nationalist movement adopted

1440-469: The sample is the gathered matter, and the sampling tool or sampler is the person or material to collect the sample. Sampling is a prerequisite for many medical tests , but generally not for medical history , physical examination and radiologic tests . In terms of sampling technique, a biopsy generally refers to a preparation where the normal tissue structure is preserved, availing for examination of both individual cells and their organization for

1500-579: The 9th century with the younger futhark . Possibly as far back as the seventh century, the common Norse language began to undergo changes that did not spread to all of Scandinavia, resulting in the appearance of two dialect areas, Old West Norse ( Norway and Iceland ) and Old East Norse ( Denmark and Sweden ). Most of the changes separating East Norse from West Norse started as innovations in Denmark, that spread through Scania into Sweden and by maritime contact to southern Norway. A change that separated Old East Norse (Runic Swedish/Danish) from Old West Norse

1560-668: The CGPS and its predecessor studies is the integration with Denmark’s comprehensive national registries . These registries provide detailed and updated information on participants, including hospital discharge diagnoses , cancer records, causes of death, prescription use, and demographic data such as education and income. This infrastructure ensures nearly 100% follow-up , eliminating a common source of bias in longitudinal studies . The registries also enable cost-effective management of large cohorts and allow disease-free participants to serve as controls for case-control studies. Numerous highly cited scientific articles have been published on

1620-594: The Danish language, and also started a period of homogenization, whereby the Copenhagen standard language gradually displaced the regional vernacular languages. Throughout the 19th century, Danes emigrated, establishing small expatriate communities in the Americas, particularly in the United States, Canada, and Argentina, where memory and some use of Danish remains today. After the Schleswig referendum in 1920 ,

1680-517: The Danish language. Herrer og Narre have frit Sprog . "Lords and jesters have free speech." Peder Syv , proverbs Following the first Bible translation, the development of Danish as a written language , as a language of religion, administration, and public discourse accelerated. In the second half of the 17th century, grammarians elaborated grammars of Danish, first among them Rasmus Bartholin 's 1657 Latin grammar De studio lingvæ danicæ ; then Laurids Olufsen Kock 's 1660 grammar of

1740-407: The Danish tongue." Heimskringla by Snorri Sturluson By the eighth century, the common Germanic language of Scandinavia, Proto-Norse , had undergone some changes and evolved into Old Norse . This language was generally called the "Danish tongue" ( Dǫnsk tunga ), or "Norse language" ( Norrœnt mál ). Norse was written in the runic alphabet , first with the elder futhark and from

1800-460: The Nordic countries have the opportunity to use their native language when interacting with official bodies in other Nordic countries without being liable for any interpretation or translation costs. Sampling (medicine) In medicine , sampling is gathering of matter from the body to aid in the process of a medical diagnosis and/or evaluation of an indication for treatment, further medical tests or other procedures. In this sense,

1860-710: The Old Norse word for "island". This monophthongization started in Jutland and spread eastward, having spread throughout Denmark and most of Sweden by 1100. Through Danish conquest, Old East Norse was once widely spoken in the northeast counties of England . Many words derived from Norse, such as "gate" ( gade ) for street, still survive in Yorkshire , the East Midlands and East Anglia, and parts of eastern England colonized by Danish Vikings . The city of York

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1920-600: The area, eventually outnumbering the Danish speakers. The political loss of territory sparked a period of intense nationalism in Denmark, coinciding with the so-called " Golden Age " of Danish culture. Authors such as N.F.S. Grundtvig emphasized the role of language in creating national belonging. Some of the most cherished Danish-language authors of this period are existential philosopher Søren Kierkegaard and prolific fairy tale author Hans Christian Andersen . The influence of popular literary role models, together with increased requirements of education did much to strengthen

1980-519: The development of cardiovascular disease, lung disease and cancer , among others. For example, in cardiovascular health, its findings established that elevated nonfasting triglyceride levels correlate with a heightened risk of myocardial infarction , ischaemic heart disease , and mortality in both men and women. Additionally, the study revealed nuanced effects of alcohol consumption on blood pressure , showing that different types of alcoholic beverages may influence blood pressure differently. In

2040-508: The exclusive use of rigsdansk , the High Copenhagen Standard, in national broadcasting, the traditional dialects came under increased pressure. In the 20th century, they have all but disappeared, and the standard language has extended throughout the country. Minor regional pronunciation variation of the standard language, sometimes called regionssprog ("regional languages") remain, and are in some cases vital. Today,

2100-596: The field of genetic research, CGPS researchers has employed Mendelian randomization to uncover the causal links between long-term alcohol consumption and coronary heart disease risk factors. In respiratory health, CGPS provided pivotal data on early identification of chronic obstructive pulmonary disease (COPD), emphasizing the roles of age and smoking exposure in disease progression and associated risks. The study's findings in metabolic health revealed that increased triglyceride metabolism , characterized by elevated levels of plasma glycerol and β-hydroxybutyrate ,

2160-451: The first English-language grammar of Danish. Literary Danish continued to develop with the works of Ludvig Holberg , whose plays and historical and scientific works laid the foundation for the Danish literary canon. With the Danish colonization of Greenland by Hans Egede , Danish became the administrative and religious language there, while Iceland and the Faroe Islands had the status of Danish colonies with Danish as an official language until

2220-426: The history of Danish into a period from 800 AD to 1525 to be "Old Danish", which he subdivided into "Runic Danish" (800–1100), Early Middle Danish (1100–1350) and Late Middle Danish (1350–1525). Móðir Dyggva var Drótt, dóttir Danps konungs, sonar Rígs er fyrstr var konungr kallaðr á danska tungu . " Dyggvi 's mother was Drott, the daughter of king Danp, Ríg 's son, who was the first to be called king in

2280-424: The language as a token of Danish identity, and the language experienced a strong surge in use and popularity, with major works of literature produced in the 18th and 19th centuries. Today, traditional Danish dialects have all but disappeared, though regional variants of the standard language exist. The main differences in language are between generations, with youth language being particularly innovative. Danish has

2340-547: The language of the courts. Since 1997, public authorities have been obliged to follow the official spelling system laid out in the Orthography Law. In the 21st century, discussions have been held with a view to create a law that would make Danish the official language of Denmark. In addition, a noticeable community of Danish speakers is in Southern Schleswig , the portion of Germany bordering Denmark, and

2400-407: The major varieties of Standard Danish are High Copenhagen Standard, associated with elderly, well to-do, and well educated people of the capital, and low Copenhagen speech traditionally associated with the working class, but today adopted as the prestige variety of the younger generations. Also, in the 21st century, the influence of immigration has had linguistic consequences, such as the emergence of

2460-422: The mid-20th century. Moders navn er vort Hjertesprog, kun løs er al fremmed Tale. Det alene i mund og bog, kan vække et folk af dvale. "Mother's name is our hearts' tongue, only idle is all foreign speech It alone, in mouth or in book, can rouse a people from sleep." N.F.S. Grundtvig , "Modersmaalet" Following the loss of Schleswig to Germany, a sharp influx of German speakers moved into

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2520-425: The results of the studies, for example that 65-79 year olds who start exercising about 4 hours a week will increase their lifespan by an average of 4 years. Other findings from the studies include the beneficial effects of drinking two glasses of red wine daily, the clinical implication of elevated triglyceride levels for the development of cardiovascular disease and the importance of genetic predisposition for

2580-484: The scope to include a larger and more diverse cohort from the Copenhagen metropolitan area . Initially, the study recruited over 100,000 participants aged 20 to 100, who contributed through questionnaires , biological samples , and physical examinations . In 2010, ethical approval enabled the integration of cardiac CT imaging , providing insights into cardiovascular biomarkers . The cohort has since expanded to include over 170,000 enrolled participants. A key feature of

2640-472: The shared written standard language remained). With the introduction of absolutism in 1660, the Danish state was further integrated, and the language of the Danish chancellery, a Zealandic variety with German and French influence, became the de facto official standard language , especially in writing—this was the original so-called rigsdansk ("Danish of the Realm"). Also, beginning in the mid-18th century,

2700-489: The study and its precursor have produced over 1,330 scientific articles in the medical press , including significant research in general and genetic epidemiology . Notable findings include the positive impact of regular physical activity on lifespan, the health benefits of moderate red wine consumption, and the role of triglycerides and genetic predisposition in developing various diseases. As of 2023, 27 doctoral theses and 96 PhD dissertations have been based on

2760-448: The study's data, with around 20 PhD students and hundreds of other researchers currently working with the data. The Copenhagen General Population Study is an offshoot of the Copenhagen City Heart Study (CCHS), known in Danish as Østerbroundersøgelsen . The CCHS was launched in 1976 by Professor Anders Tybjærg Hansen and cardiologists Dr. Peter Schnohr  [ da ] , Dr. Gorm Jensen and statistician Jørgen Nyboe, and began as

2820-486: The three languages can often understand the others fairly well, though studies have shown that the mutual intelligibility is asymmetric: Norwegian speakers generally understand both Danish and Swedish far better than Swedes or Danes understand each other. Concomitantly, Swedes and Danes understand Norwegian better than they understand each other's languages. Norwegian occupies the middle position in terms of intelligibility because of its shared border with Sweden, resulting in

2880-445: The turn of the 20th century. Danish itself can be divided into three main dialect areas: Jutlandic (West Danish), Insular Danish (including the standard variety), and East Danish (including Bornholmian and Scanian ). According to the view that Scandinavian is a dialect continuum, East Danish can be considered intermediary between Danish and Swedish, while Scanian can be considered a Swedified East Danish dialect, and Bornholmian

2940-411: The vernacular language to be accessible also to those who were not Latinate. The Jutlandic Law and Scanian Law were written in vernacular Danish in the early 13th century. Beginning in 1350, Danish began to be used as a language of administration, and new types of literature began to be written in the language, such as royal letters and testaments. The orthography in this period was not standardized nor

3000-469: The vernacular, such as the plural form of verbs, should be conserved in writing (i.e. han er "he is" vs. de ere "they are"). The East Danish provinces were lost to Sweden after the Second Treaty of Brömsebro (1645) after which they were gradually Swedified; just as Norway was politically severed from Denmark, beginning also a gradual end of Danish influence on Norwegian (influence through

3060-516: The whore-bed with another man's wife and he comes away alive..." Jutlandic Law, 1241 In the medieval period, Danish emerged as a separate language from Swedish. The main written language was Latin, and the few Danish-language texts preserved from this period are written in the Latin alphabet, although the runic alphabet seems to have lingered in popular usage in some areas. The main text types written in this period are laws, which were formulated in

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3120-492: The word by , meaning ‘village’ or ‘town’, occurs in many English place-names, such as Whitby and Selby , as remnants of the Viking occupation . During that period English adopted ‘are’, the third person plural form of the verb ‘to be’, as well as the personal pronouns ‘they’, ‘them’ and ‘their’ from contemporary Old Norse. Danish is largely mutually intelligible with Norwegian and Swedish . A proficient speaker of any of

3180-489: The written languages are compatible, spoken Danish is distinctly different from Norwegian and Swedish and thus the degree of mutual intelligibility with either is variable between regions and speakers . Until the 16th century, Danish was a continuum of dialects spoken from Southern Jutland and Schleswig to Scania with no standard variety or spelling conventions. With the Protestant Reformation and

3240-492: Was a territory ruled by Denmark–Norway , one of whose official languages was Danish. Though Danish ceased to be an official language in Iceland in 1944, it is still widely used and is a mandatory subject in school, taught as a second foreign language after English. No law stipulates an official language for Denmark, making Danish the de facto official language only. The Code of Civil Procedure does, however, lay down Danish as

3300-457: Was also one of two official languages of Greenland (alongside Greenlandic ). Danish now acts as a lingua franca in Greenland, with a large percentage of native Greenlanders able to speak Danish as a second language (it was introduced into the education system as a compulsory language in 1928). About 10% of the population speaks Danish as their first language , due to immigration. Iceland

3360-488: Was mostly supplanted by the Low German spise . As well as loanwords, new words can be freely formed by compounding existing words. In standard texts of contemporary Danish, Middle Low German loans account for about 16–17% of the vocabulary, Graeco-Latin loans 4–8%, French 2–4% and English about 1%. Danish and English are both Germanic languages. Danish is a North Germanic language descended from Old Norse, and English

3420-627: Was once the Viking settlement of Jorvik. Several other English words derive from Old East Norse, for example "knife" ( kniv ), "husband" ( husbond ), and "egg" ( æg ). The suffix "-by" for 'town' is common in place names in Yorkshire and the east Midlands, for example Selby, Whitby, Derby, and Grimsby. The word "dale" meaning valley is common in Yorkshire and Derbyshire placenames. Fangær man saar i hor seng mæth annæns mansz kunæ. oc kumær han burt liuænd... . "If one catches someone in

3480-463: Was still not standardized and the principles for doing so were vigorously discussed among Danish philologists. The grammar of Jens Pedersen Høysgaard was the first to give a detailed analysis of Danish phonology and prosody, including a description of the stød . In this period, scholars were also discussing whether it was best to "write as one speaks" or to "speak as one writes", including whether archaic grammatical forms that had fallen out of use in

3540-469: Was the change of the diphthong æi (Old West Norse ei ) to the monophthong e , as in stæin to sten . This is reflected in runic inscriptions where the older read stain and the later stin . Also, a change of au as in dauðr into ø as in døðr occurred. This change is shown in runic inscriptions as a change from tauþr into tuþr . Moreover, the øy (Old West Norse ey ) diphthong changed into ø , as well, as in

3600-474: Was the spoken language, and the regional laws demonstrate the dialectal differences between the regions in which they were written. Throughout this period, Danish was in contact with Low German , and many Low German loan words were introduced in this period. With the Protestant Reformation in 1536, Danish also became the language of religion, which sparked a new interest in using Danish as

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