A combination drug or a fixed-dose combination ( FDC ) is a medicine that includes two or more active ingredients combined in a single dosage form . Terms like "combination drug" or "combination drug product" can be common shorthand for an FDC product (since most combination drug products are currently FDCs), although the latter is more precise if in fact referring to a mass-produced product having a predetermined combination of drugs and respective dosages (as opposed to customized polypharmacy via compounding ). And it should also be distinguished from the term "combination product" in medical contexts, which without further specification can refer to products that combine different types of medical products—such as device/drug combinations as opposed to drug/drug combinations. When a combination drug product (whether fixed-dose or not) is a "pill" (i.e., a tablet or capsule), then it may also be a kind of " polypill " or combopill.
3-488: Ipratropium bromide/salbutamol , sold under the brand name Combivent among others, is a combination medication used to treat chronic obstructive pulmonary disease (COPD). It contains ipratropium (an anticholinergic ) and salbutamol (albuterol, a β 2 -adrenergic agonist ). Common side effects include sore throat, muscle cramps, and nausea. Other side effects may include bronchospasm , allergic reactions , and upper respiratory tract infections . Safety in pregnancy
6-484: Is unclear. The combination was approved for medical use in the United States in 1996. It is available as a generic medication . In 2022, it was the 178th most commonly prescribed medication in the United States, with more than 2 million prescriptions. Ipratropium bromide/salbutamol can be used for the treatment of COPD and asthma. Since Combivent contains a chlorofluorocarbon -based propellant, its use
9-504: Was discontinued in 2013 in the United States and other countries. This is because chlorofluorocarbons are attributed to depletion of the ozone layer . Combination medication Initially, fixed-dose combination drug products were developed to target a single disease (such as with antiretroviral FDCs used against AIDS ). However, FDCs may also target multiple diseases/conditions. In cases of FDCs targeting multiple conditions, such conditions might often be related—in order to increase
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