21-488: Bromo-Seltzer is a brand of antacid formulated to relieve pain occurring together with heartburn , upset stomach , or acid indigestion . It originally contained sodium bromide and acetanilide , both toxic substances which were eventually removed. Its current formulation contains the pain reliever aspirin and two reactive chemicals – sodium bicarbonate and citric acid – which creates effervescence when mixed with water. Sodium bicarbonate
42-476: A 2013 study. Alternative sodium-free formulations containing magnesium salts may cause diarrhea, whereas those containing calcium or aluminum may cause constipation . Long-term use of antacids containing aluminum may increase the risk of developing osteoporosis . In vitro studies have found a potential for acid rebound to occur due to antacid overuse, however the significance of this finding has been called into question. When an excess amount of acid
63-440: A class of tranquilizers that were withdrawn from the U.S. market in 1975 due to their toxicity. Their sedative effect probably accounted for Bromo-Seltzer's popularity as a hangover remedy . Early formulas also used acetanilide as the analgesic ingredient; it is now known to be toxic. Acetanilide was replaced with its metabolite acetaminophen , and its current formulation uses aspirin , sodium bicarbonate , and citric acid ,
84-576: A combination of two salts , such as magnesium carbonate and aluminum hydroxide (e.g., hydrotalcite ). Antacids are available over the counter and are taken by mouth to quickly relieve occasional heartburn , the major symptom of gastroesophageal reflux disease and indigestion . Treatment with antacids alone is symptomatic and only justified for minor symptoms. Alternative uses for antacids include constipation, diarrhea, hyperphosphatemia, and urinary alkalization. Some antacids are also used as an adjunct to pancreatic enzyme replacement therapy in
105-476: A liquid preparation over a tablet is that liquids may provide quicker relief, however this may coincide with a shorter duration of action. Chewable tablets are one of the most common forms of antacids, most frequently made from carbonate or hydroxide salts , and are readily available over the counter. Upon reaching the stomach , the powdered antacid salts bind to hydronium (H ) ions, producing chloride salts, carbon dioxide, and water. This process reduces
126-541: Is an antacid. Bromo-Seltzer was invented in 1888 by Isaac E. Emerson and produced by the Emerson Drug Company of Baltimore, Maryland . It was sold in the United States in the form of effervescent granules that were mixed with water before ingestion . The product took its name from a component of the original formula, sodium bromide ; each dose contained 3.2 mEq /teaspoon of it. Bromides are
147-470: Is listed on the National Register of Historic Places . The tower originally held a 51-foot (16m) representation of a Bromo-Seltzer bottle at its top, glowing blue and rotating on a vertical axis. The sign weighed 20 tons (18.1 tonnes), included 314 incandescent light bulbs, and was topped with a crown. The sign was removed in 1936 because of structural concerns. Emerson, who traveled widely, said
168-730: Is mentioned in John Steinbeck 's 1939 novel The Grapes of Wrath . Drugstore Bromo-Seltzer dispensers are mentioned in Georges Simenon 's 1949 detective novel Maigret chez le coroner that takes place in Arizona. It is mentioned in several songs, including " Bewitched, Bothered and Bewildered " by Rodgers and Hart , " Adelaide's Lament " in the musical Guys and Dolls , and " Pachuco Cadaver " by Captain Beefheart and his Magic Band . In Spike Jones ' version of Laura ,
189-490: Is produced in the stomach , the natural mucous barrier that protects the lining of the stomach can degrade, leading to pain and irritation . There is also potential for the development of acid reflux , which can cause pain and damage to the esophagus . Antacids contain alkaline ions that chemically neutralize stomach gastric acid , reducing damage to the stomach lining and esophagus , and relieving pain. Some antacids also inhibit pepsin , an enzyme that can damage
210-547: Is responsible for some of these interactions (e.g. fluoroquinolones , tetracyclines ), leading to decreased absorption of the chelated drug. Some interactions may be due to the pH increase observed in the stomach following antacid ingestion , leading to increased absorption of weak acids, and decreased absorption of weak bases. Antacids also cause an increase in pH of the urine (alkalization), which may cause increased blood concentrations of weak bases, and increased excretion of weak acids. A proposed method to mitigate
231-533: The esophagus in acid reflux . Antacids do not directly inhibit acid secretion , and thus are distinct from acid-reducing drugs like H 2 -receptor antagonists or proton pump inhibitors . Antacids do not kill the bacteria Helicobacter pylori , which causes most ulcers . Antacids are mainly classified into two categories: Antacids are known to interact with several oral medications , including fluoroquinolone and tetracycline antibiotics , iron , itraconazole , and prednisone . Metal chelation
SECTION 10
#1732797921737252-522: The mucous membrane of the stomach . Some brands include Alka-Seltzer , Gaviscon, Tums , Gelusil and Eno . [REDACTED] The dictionary definition of antacid at Wiktionary Laura (1945 song) "Laura" is a 1945 popular song. The music, composed by David Raksin for the 1944 movie Laura , which starred Gene Tierney and Dana Andrews , is heard frequently in the movie. The film's director, Otto Preminger , had originally wanted to use Duke Ellington 's " Sophisticated Lady " as
273-543: The chorus chants "Bromo-Seltzer, Bromo-Seltzer..." to evoke the sound of a chugging train. This pharmacology -related article is a stub . You can help Misplaced Pages by expanding it . Antacid An antacid is a substance which neutralizes stomach acidity and is used to relieve heartburn , indigestion , or an upset stomach. Some antacids have been used in the treatment of constipation and diarrhea . Marketed antacids contain salts of aluminum , calcium , magnesium , or sodium . Some preparations contain
294-455: The coating of the delayed-release tablet will dissolve, leading to degradation of the drug if it is pH sensitive . Antacids may be formulated with other active ingredients such as simethicone to control gas , or alginic acid to act as a physical barrier to acid. Several liquid antacid preparations are marketed . Common liquid preparations include milk of magnesia and magnesium/aluminum combinations . A potential advantage of using
315-751: The concentration of H ions in the stomach, raising the pH and neutralizing the acid. Common carbonate salts available in tablet form include those of calcium, magnesium, aluminum, and sodium. Some common American brands are Tums , Gaviscon chewable tablets, and Maalox chewable tablets. Effervescent tablets are tablets which are designed to dissolve in water , and then release carbon dioxide . Common ingredients include citric acid and sodium bicarbonate , which react when in contact with water to produce carbon dioxide . Effervescent antacids may also contain aspirin , sodium carbonate , or tartaric acid . Those containing aspirin may cause further gastric irritation and ulceration due to aspirin 's effects on
336-412: The effects of stomach acidity and chelation on drug absorption is to space out the administration of antacids with interacting medications by at least two hours, however this method has not been well studied for drugs affected by urine alkalization . There are concerns regarding interactions between delayed-release tablets and antacids, as antacids may increase the stomach pH to a point at which
357-624: The fizz reminded him of the bubbling action of Mount Bromo , a volcano in Java. Bromo-Seltzer is mentioned in several films and TV shows, including The Crooked Circle (1932), Bed of Roses (1933), Topper (1937), Wonder Man (1945), Somewhere in the Night (1946), The Postman Always Rings Twice (1981), The Hudsucker Proxy (1994), the 1998 The Simpsons episode " Bart Carny ", and in Golden Girls (Season 4, Episode 1). It
378-633: The latter two of which provide the carbonation . Bromo-Seltzer's main offices and factory were located in downtown Baltimore, Maryland, at the corner of West Lombard and South Eutaw streets. The factory's most notable feature was the Emerson Bromo-Seltzer Tower , built in 1911, whose four clock faces are ringed by letters spelling out the product name. The tower was patterned on the Palazzo Vecchio in Florence, Italy , and
399-561: The song "Laura". According to Mercer, he had not yet seen the movie when he wrote the lyrics but was aware that it was a romantic, somewhat haunting story. The song became a jazz standard and has been recorded more than 400 times. Some of the best-known versions are by Woody Herman , Dave Brubeck , Johnny Johnston , Emil Newman , David Rose , Billy Eckstine , Charlie Parker , J. J. Johnson , Carly Simon , Frank Sinatra , Spike Jones and Julie London (included on her 1955 debut album Julie Is Her Name, Vol. 1 ). The first 10 notes of
420-416: The theme, but Raksin was not convinced that it was suitable. Angered, Preminger gave Raksin one weekend to compose an alternative melody. Raksin later said, and maintained for the rest of his days, that when, over that weekend, his wife sent him a "Dear John" letter , the haunting theme seemed to write itself. The lyrics were written by Johnny Mercer after the film made the tune popular, so he had to title
441-470: The treatment of pancreatic insufficiency . Non-particulate antacids ( sodium citrate ) increase gastric pH with little or no effect on gastric volume, and therefore may see some limited use in pre-operative procedures. Sodium citrate should be given within 1 hour of surgery to be the most effective. Conventional effervescent tablets contain a significant amount of sodium and are associated with increased odds of adverse cardiovascular events according to
SECTION 20
#1732797921737#736263