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68-405: Not unlike most other larger villages in the country, locals typically distinguish an "upper" ( горна ) and "lower" ( долна ) quarter ( маала ). Historically, the latter developed from the expansion of the former. The neighborhood Bukovski Livadi (Буковски Ливади, "Bukovo Meadows") comprises ten residential streets and is located at the entrance to the village; often considered a part of Bukovo, it

136-404: A Mahalle council ( Persian : شورای محله ), a quarter mosque, and a small parkette. A maalo (sometimes maale ), plural maala ( Macedonian : маало / маале, маала ) is a synonym for neighborhood in colloquial speech, but can also appear as part of a neighborhood name, such as Skopje's "Debar maalo", and Bitola's "Jeni maale", "Madzar maala". In Romanian, the word mahala has come to have

204-625: A healthy diet are also recommended. Supportive care in severe cases includes treatment to relieve symptoms , fluid therapy , oxygen support and prone positioning , and medications or devices to support other affected vital organs. More severe cases may need treatment in hospital. In those with low oxygen levels, use of the glucocorticoid dexamethasone is recommended to reduce mortality. Noninvasive ventilation and, ultimately, admission to an intensive care unit for mechanical ventilation may be required to support breathing. Extracorporeal membrane oxygenation (ECMO) has been used to address

272-511: A muhtasib and a territorial muhtasibat . They were urban divisions in central Asian communities which today exist in Uzbekistan , Kyrgyzstan , and Tajikistan . Historically, mahallas were autonomous social institutions built around familial ties and Islamic rituals. Before the establishment of the Soviet rule in central Asia, mahallas fulfilled local self-government functions connecting

340-627: A variant of concern (VoC) or a variant of interest (VoI). Many of these variants have shared the more infectious D614G . As of May 2023, the WHO had downgraded all variants of concern to previously circulating as these were no longer detected in new infections. Sub-lineages of the Omicron variant (BA.1 – BA.5) were considered separate VoCs by the WHO until they were downgraded in March 2023 as no longer widely circulating. As of 24 September 2024 ,

408-493: A comprehensive international study. Such deaths include deaths due to healthcare capacity constraints and priorities, as well as reluctance to seek care (to avoid possible infection). Further research may help distinguish the proportions directly caused by COVID-19 from those caused by indirect consequences of the pandemic. In May 2022, the WHO estimated the number of excess deaths by the end of 2021 to be 14.9 million compared to 5.4 million reported COVID-19 deaths, with

476-595: A large number of people". During the COVID-19 pandemic, as with other pandemics, the meaning of this term has been challenged. The end of a pandemic or other epidemic only rarely involves the total disappearance of a disease, and historically, much less attention has been given to defining the ends of epidemics than their beginnings. The ends of particular epidemics have been defined in a variety of ways, differing according to academic field, and differently based on location and social group. An epidemic's end can be considered

544-451: A median range of 0.24% to 1.49%. IFRs rise as a function of age (from 0.002% at age 10 and 0.01% at age 25, to 0.4% at age 55, 1.4% at age 65, 4.6% at age 75, and 15% at age 85). These rates vary by a factor of ≈10,000 across the age groups. For comparison, the IFR for middle-aged adults is two orders of magnitude higher than the annualised risk of a fatal automobile accident and much higher than

612-824: A random sample have consistently found that total infections considerably exceed the reported case counts. Many countries, early on, had official policies to not test those with only mild symptoms. The strongest risk factors for severe illness are obesity, complications of diabetes , anxiety disorders, and the total number of conditions. During the start of the COVID-19 pandemic it was not clear whether young people were less likely to be infected, or less likely to develop symptoms and be tested. A retrospective cohort study in China found that children and adults were just as likely to be infected. Among more thorough studies, preliminary results from 9 April 2020 found that in Gangelt ,

680-512: A separate type of settlement administration on some occasions. In rural mountainous areas, villages were often scattered and consisted of relatively separate mahalas with badly developed infrastructure . Today, settlements are divided into towns or villages, and the official division of towns is into quarters. It today is used almost always to refer to the Roma neighbourhoods of towns such as Arman Mahala . In Greece , mahalas ( Greek : μαχαλάς )

748-461: A social phenomenon, not just a biological one. Time reported in March 2024 that expert opinions differ on whether or not COVID-19 is considered endemic or pandemic, and that the WHO continued to call the disease a pandemic on its website. During the initial outbreak in Wuhan , the virus and disease were commonly referred to as "coronavirus", "Wuhan coronavirus", "the coronavirus outbreak" and

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816-451: A test. Conversely, deaths of people who died from underlying conditions following a positive test may be included. Countries such as Belgium include deaths from suspected cases, including those without a test, thereby increasing counts. Official death counts have been claimed to underreport the actual death toll, because excess mortality (the number of deaths in a period compared to a long-term average) data show an increase in deaths that

884-649: Is actually a suburb of the City of Bitola. The village collectively celebrates the Feast of the Transfiguration as its local holiday — referred to as "the Day" ( Денот ) — after the village's eponymous monastery. The celebration of Lazarus Saturday is also upheld devotedly, a tradition which has very nearly died out in the rest of the country. The village is famous for its crushed red pepper or chilli flakes which it

952-477: Is an Islamic congregation or parish. Typically, a mahalla supports a single mosque. An imam is seen as the spiritual head of a mahalla. Mahallas are directly subordinate to a city or town , especially an electoral district, for ritual and representative purposes. Unlike a ward , it is an optional and non-elective unit of a city corporation or municipal corporation . Mahalla also means an urban neighbourhood. In Bulgaria , mahalas were historically considered

1020-518: Is an official administrative unit in many Middle Eastern countries. The word was brought to the Balkans through Ottoman Turkish mahalle , but it originates in Arabic محلة ( mähallä ), from the root meaning "to settle", "to occupy". In September 2017, a Turkish-based association referred to the historical mahalle by organizing a festival with the title "Mahalla" in the frame of parallel events of

1088-518: Is associated with COVID-19 and is reported in as many as 88% of cases. The disease is mainly transmitted via the respiratory route when people inhale droplets and small airborne particles (that form an aerosol ) that infected people exhale as they breathe, talk, cough, sneeze, or sing. Infected people are more likely to transmit COVID-19 when they are physically close to other non-infected individuals. However, infection can occur over longer distances, particularly indoors. SARS‑CoV‑2 belongs to

1156-487: Is considered a neighborhood. Sometimes it is considered a quarter of a small town or a gypsy neighborhood. The township of Szentendre lost most of its population during the Ottoman era, and was repopulated by various migrant groups from the Balkans - Serbs , Dalmatians , Bosniaks and the like. They built their own churches and created their own neighborhoods around them. They called them mahala or mehala , using

1224-564: Is credited with inventing. 19th-century geographers write that Bukovo was once a completely Orthodox Christian village with a school run by the Patriarchate of Constantinople . According to Bulgarian ethnographer Vasil Kanchov in 1900, the village of Bukovo was inhabited by 1490 Patriarchists Bulgarians. According to Geographers Dimitri Mishev and D. M. Brancoff, the town had a total population of 2.400 people in 1905, all Patriarchist Bulgarians ( sic ) " Grecomans ". According to

1292-611: Is discouraged altogether by the World Health Organization (WHO), due to limited evidence of its efficacy. The severity of COVID-19 varies. It may take a mild course with few or no symptoms, resembling other common upper respiratory diseases such as the common cold . In 3–4% of cases (7.4% for those over age 65) symptoms are severe enough to cause hospitalisation. Mild cases typically recover within two weeks, while those with severe or critical diseases may take three to six weeks to recover. Among those who have died,

1360-439: Is intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes coronavirus disease 2019 ( COVID-19 ). Prior to the COVID-19 pandemic, an established body of knowledge existed about the structure and function of coronaviruses causing diseases like severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). This knowledge accelerated

1428-490: Is not explained by COVID-19 deaths alone. Using such data, estimates of the true number of deaths from COVID-19 worldwide have included a range from 18.2 to 33.5 million (≈27.4 million) by 18 November 2023 by The Economist , as well as over 18.5 million by 1 April 2023 by the Institute for Health Metrics and Evaluation and ≈18.2 million (earlier) deaths between 1 January 2020, and 31 December 2021, by

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1496-452: Is the ratio of deaths to diagnoses. This metric can be misleading because of the delay between symptom onset and death and because testing focuses on symptomatic individuals. Based on Johns Hopkins University statistics, the global CFR was 1.02 percent (6,881,955 deaths for 676,609,955 cases) as of 10 March 2023. The number varies by region and has generally declined over time. Several variants have been named by WHO and labelled as

1564-406: Is the seventh known coronavirus to infect people, after 229E , NL63 , OC43 , HKU1 , MERS-CoV , and the original SARS-CoV . The standard method of testing for presence of SARS-CoV-2 is a nucleic acid test , which detects the presence of viral RNA fragments. As these tests detect RNA but not infectious virus, its "ability to determine duration of infectivity of patients is limited." The test

1632-614: Is typically done on respiratory samples obtained by a nasopharyngeal swab ; however, a nasal swab or sputum sample may also be used. The WHO has published several testing protocols for the disease. Preventive measures to reduce the chances of infection include getting vaccinated, staying at home or spending more time outdoors, avoiding crowded places, keeping distance from others, wearing a mask in public, ventilating indoor spaces, managing potential exposure durations, washing hands with soap and water often and for at least twenty seconds, practising good respiratory hygiene, and avoiding touching

1700-605: The Balkans , Western Asia , the Indian subcontinent , and nearby nations. Historically, mahallas were autonomous social institutions built around familial ties and Islamic rituals. Today it is popularly recognised also by non-Muslims as a neighbourhood in large cities and towns. Mahallas lie at the intersection of private family life and the public sphere. Important community-level management functions are performed through mahalle solidarity, such as religious ceremonies, life-cycle rituals, resource management and conflict resolution. It

1768-514: The Huanan Seafood Wholesale Market there, but it is possible that human-to-human transmission began earlier. Molecular clock analysis suggests that the first cases were likely to have been between October and November 2019. The scientific consensus is that the virus is most likely of a zoonotic origin, from bats or another closely related mammal. While other explanations such as speculations that SARS-CoV-2

1836-407: The Institute for Health Metrics and Evaluation estimating the true number of cases as of early 2022 to be in the billions. One measure that public health officials and policymakers have used to monitor the pandemic and guide decision-making is the test positivity rate ("percent positive"). According to Johns Hopkins in 2020, one benchmark for a "too high" per cent positive is 5%, which was used by

1904-602: The basic reproduction number (R 0 ) for COVID-19 in January 2020 were between 1.4 and 2.5, but a subsequent analysis claimed that it may be about 5.7 (with a 95 per cent confidence interval of 3.8 to 8.9). In December 2021, the number of cases continued to climb due to several factors, including new COVID-19 variants. As of that 28   December, 282,790,822 individuals worldwide had been confirmed as infected. As of 14 April 2022 , over 500 million cases were confirmed globally. Most cases are unconfirmed, with

1972-474: The variants of interest as specified by the World Health Organization are BA.2.86 and JN.1, and the variants under monitoring are JN.1.7, KP.2, KP.3, KP.3.1.1, JN.1.18, LB.1, and XEC. Symptoms of COVID-19 are variable, ranging from mild symptoms to severe illness. Common symptoms include headache, loss of smell and taste , nasal congestion and runny nose , cough, muscle pain , sore throat , fever, diarrhoea , and breathing difficulties . People with

2040-429: The "Wuhan coronavirus outbreak", with the disease sometimes called "Wuhan pneumonia ". In January 2020, the WHO recommended 2019-nCoV and 2019-nCoV acute respiratory disease as interim names for the virus and disease per 2015 international guidelines against using geographical locations (e.g. Wuhan, China), animal species, or groups of people in disease and virus names in part to prevent social stigma . WHO finalised

2108-572: The 15th Istanbul Biennial . The festival in Istanbul features cultural initiatives of civil society and artists from the Middle East, Europe, the Balkans and Turkey. Against the background of the ongoing migration crisis, all participants of the festival focus their work using themes of hospitality, identity formation, homelessness, migration, fluctuation, the changing of an existing order and

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2176-464: The 2002 census, the village had a total population of 3,494 people: 3,456 ethnic Macedonians , 11 Albanians , 14 Turks , 1 Aromanian , 6 Serbs and 6 declared as "other". Mahala A mahallah , also mahalla , mahallya , mahalle , mohalla , mehalla , or mehalle is an Arabic word variously translated as district , quarter , ward , or neighborhood in many parts of the Arab world ,

2244-621: The Ottoman nomenclature, and the word is still in use to describe these small quarters of the town today. In India, the word mohalla is used in Hindi and Urdu to refer to a "neighbourhood". The "mahalle" is the smallest urban administrative division in Iran . Each city is divided into a few Mantaqe s, ( Persian : منطقه ), which is then divided into Nahiye s ( Persian : ناحیه ), further subdivided to Mahalle ( Persian : محله ), usually having

2312-640: The WHO in the past. As of 10 March 2023, more than 6.88   million deaths had been attributed to COVID-19. The first confirmed death was in Wuhan on 9 January 2020. These numbers vary by region and over time, influenced by testing volume, healthcare system quality, treatment options, government response, time since the initial outbreak, and population characteristics, such as age, sex, and overall health. Multiple measures are used to quantify mortality. Official death counts typically include people who died after testing positive. Such counts exclude deaths without

2380-419: The WHO, US, European Union, and Australia. On 12 November 2022, the WHO released its Global Vaccine Market Report. The report indicated that "inequitable distribution is not unique to COVID-19 vaccines"; countries that are not economically strong struggle to obtain vaccines. On 14 November 2022, the first inhalable vaccine was introduced, developed by Chinese biopharmaceutical company CanSino Biologics , in

2448-595: The Yeldeğirmeni Sanat Merkezi. The word is used in many languages and countries to mean neighborhood or location and originated in Arabic محلة ( maḥalla ), from the root meaning 'to settle', 'to occupy', derived from the verb halla (to untie), as in untying a pack horse or camel to make a camp. In ancient cultures, hospitality involved welcoming a stranger at the host location and offering him food, shelter and safety. That demonstration of hospitality centred on

2516-467: The belief that strangers should be assisted and protected while they travel. A mahala was a relatively-independent quarter of a larger village or a town, usually with its own school , religious building or buildings, mayor's representative etc. Mahalas are often named after the first settler or, when ethnically separate, according to the dominant ethnicity. In the Ottoman Empire, the "mahalle"

2584-448: The broad family of viruses known as coronaviruses . It is a positive-sense single-stranded RNA (+ssRNA) virus, with a single linear RNA segment. Coronaviruses infect humans, other mammals, including livestock and companion animals, and avian species. Human coronaviruses are capable of causing illnesses ranging from the common cold to more severe diseases such as Middle East respiratory syndrome (MERS, fatality rate ≈34%). SARS-CoV-2

2652-648: The centre of a major infection cluster in Germany, 15 per cent of a population sample tested positive for antibodies . Screening for COVID-19 in pregnant women in New York City , and blood donors in the Netherlands, found rates of positive antibody tests that indicated more infections than reported. Seroprevalence -based estimates are conservative as some studies show that persons with mild symptoms do not have detectable antibodies. Initial estimates of

2720-760: The city of Shanghai, China. For the first two years of the pandemic, no specific and effective treatment or cure was available. In 2021, the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) approved the oral antiviral protease inhibitor , Paxlovid (nirmatrelvir plus the HIV antiviral ritonavir ), to treat adult patients. FDA later gave it an EUA. Most cases of COVID-19 are mild. In these, supportive care includes medication such as paracetamol or NSAIDs to relieve symptoms (fever, body aches, cough), adequate intake of oral fluids and rest. Good personal hygiene and

2788-484: The cumulative number of infected individuals (including asymptomatic and undiagnosed infections and excluding vaccinated infected individuals). It is expressed in percentage points. Other studies refer to this metric as the infection fatality risk . In November 2020, a review article in Nature reported estimates of population-weighted IFRs for various countries, excluding deaths in elderly care facilities, and found

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2856-441: The development of various vaccine platforms during early 2020. The initial focus of SARS-CoV-2 vaccines was on preventing symptomatic and severe illness. The COVID-19 vaccines are widely credited for their role in reducing the severity and death caused by COVID-19. As of March 2023, more than 5.5 billion people had received one or more doses (11.8 billion in total) in over 197 countries. The Oxford-AstraZeneca vaccine

2924-588: The dissolution of borders. The second Mahalla Festival took place 2018 in Valletta , Malta , in the frame of European Capital of Culture under the title "Generating New Narratives". The third Mahalla Festival took place in 2020 under the title " Wandering Towers " with online and physical events due to the COVID-19 pandemic. The 2021 edition, " Murmuration ", took place in the Istanbul district of Kadıköy at

2992-513: The eyes, nose, or mouth with unwashed hands. Those diagnosed with COVID-19 or who believe they may be infected are advised by healthcare authorities to stay home except to get medical care, call ahead before visiting a healthcare provider, wear a face mask before entering the healthcare provider's office and when in any room or vehicle with another person, cover coughs and sneezes with a tissue, regularly wash hands with soap and water and avoid sharing personal household items. A COVID-19 vaccine

3060-530: The general public beginning in December 2020, made available through government and international programs such as COVAX , aiming to provide vaccine equity . Treatments include novel antiviral drugs and symptom control. Common mitigation measures during the public health emergency included travel restrictions , lockdowns , business restrictions and closures, workplace hazard controls , mask mandates , quarantines, testing systems, and contact tracing of

3128-833: The government. Mahallas are a common unit not only in Uzbekistan, but in Tajikistani cities like Khujand and Kyrgyzstani cities like Osh . In Turkey, mahalle , which may be translated as 'neighborhood', was traditionally a kind of sub-village settlement, one that could be found in both rural settings and in towns. COVID-19 pandemic The COVID-19 pandemic (also known as the coronavirus pandemic and COVID pandemic ), caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ), began with an outbreak of COVID-19 in Wuhan , China, in December 2019. It spread to other areas of Asia, and then worldwide in early 2020. The World Health Organization (WHO) declared

3196-665: The infected. The pandemic caused severe social and economic disruption around the world, including the largest global recession since the Great Depression . Widespread supply shortages , including food shortages , were caused by supply chain disruptions and panic buying . Reduced human activity led to an unprecedented temporary decrease in pollution . Educational institutions and public areas were partially or fully closed in many jurisdictions, and many events were cancelled or postponed during 2020 and 2021. Telework became much more common for white-collar workers as

3264-487: The issue of respiratory failure. Existing drugs such as hydroxychloroquine , lopinavir/ritonavir , and ivermectin are not recommended by US or European health authorities, as there is no good evidence they have any useful effect. The antiviral remdesivir is available in the US, Canada, Australia, and several other countries, with varying restrictions; however, it is not recommended for use with mechanical ventilation, and

3332-548: The mahalle is represented in the municipality and government by its muhtar . The muhtarlık, the office of the muhtar, has been designed as the smallest administrative office, with representative and enforcement powers at the local level. In some cases, however, the muhtar acts as not only the representative of the government towards the community but also the head of the community toward the government and subverts official government policies by intricate face-to-face mahalle-level relationships. A mahalla ( pronounced mo-hol-la ),

3400-576: The majority of the unreported 9.5 million deaths believed to be direct deaths due the virus, rather than indirect deaths. Some deaths were because people with other conditions could not access medical services . A December 2022 WHO study estimated excess deaths from the pandemic during 2020 and 2021, again concluding ≈14.8 million excess early deaths occurred, reaffirming and detailing their prior calculations from May as well as updating them, addressing criticisms. These numbers do not include measures like years of potential life lost and may make

3468-495: The official names COVID-19 and SARS-CoV-2 on 11 February 2020. Tedros Adhanom Ghebreyesus explained: CO   for corona , VI   for virus , D   for disease and 19 for when the outbreak was first identified (31 December 2019). WHO additionally uses "the COVID-19 virus" and "the virus responsible for COVID-19" in public communications. WHO named variants of concern and variants of interest using Greek letters . The initial practice of naming them according to where

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3536-534: The outbreak a public health emergency of international concern (PHEIC) on 30 January 2020, and assessed the outbreak as having become a pandemic on 11 March. COVID-19 symptoms range from asymptomatic to deadly, but most commonly include fever, sore throat , nocturnal cough , and fatigue. Transmission of the virus is often through airborne particles . Mutations have produced many strains (variants) with varying degrees of infectivity and virulence . COVID-19 vaccines were developed rapidly and deployed to

3604-407: The pandemic 2021's leading cause of death . The time between symptom onset and death ranges from   6 to 41 days, typically about 14 days. Mortality rates increase as a function of age. People at the greatest mortality risk are the elderly and those with underlying conditions. The infection fatality ratio (IFR) is the cumulative number of deaths attributed to the disease divided by

3672-495: The pandemic evolved. Misinformation circulated through social media and mass media , and political tensions intensified . The pandemic raised issues of racial and geographic discrimination , health equity , and the balance between public health imperatives and individual rights . The WHO ended the PHEIC for COVID-19 on 5 May 2023. The disease has continued to circulate, but as of 2024, experts were uncertain as to whether it

3740-478: The population's age structure and the age-specific pattern of infections. There have also been reviews that have compared the fatality rate of this pandemic with prior pandemics, such as MERS-CoV. For comparison the infection mortality rate of seasonal flu in the United States is 0.1%, which is 13 times lower than COVID-19. Another metric in assessing death rate is the case fatality ratio (CFR), which

3808-487: The private sphere with the public sphere. Religious rituals, life-cycle crisis ceremonies, resource management, conflict resolution, and many other community activities were performed at the mahalla, in other words, on the neighbourhood level. An informal council of elders, called oqsoqol (or " aksakal ") provided leadership. After their inclusion in the Soviet Union, informal mahalla organizations were placed under

3876-462: The risk of dying from seasonal influenza . In December 2020, a systematic review and meta-analysis estimated that population-weighted IFR was 0.5% to 1% in some countries (France, Netherlands, New Zealand, and Portugal), 1% to 2% in other countries (Australia, England, Lithuania, and Spain), and about 2.5% in Italy. This study reported that most of the differences reflected corresponding differences in

3944-496: The same infection may have different symptoms, and their symptoms may change over time. Three common clusters of symptoms have been identified: one respiratory symptom cluster with cough, sputum , shortness of breath, and fever; a musculoskeletal symptom cluster with muscle and joint pain, headache, and fatigue; a cluster of digestive symptoms with abdominal pain, vomiting, and diarrhoea. In people without prior ear, nose, and throat disorders, loss of taste combined with loss of smell

4012-473: The state control and served as local extensions of the Soviet government. Mahallas were thought to be "eyes" and "ears" of the Soviet government; mahalla became a control mechanism of the state. Mahalla leaders were then appointed by the government. Mahalla level state-society relationships were more complex, however, as their leaders could serve as henchmen as well as act as buffers between the local community and

4080-490: The state. Due to intimate, face-to face relationships dominant at the mahalla level, mahalla organizations could often shield the community from the incursions of the state. Since 1993, the Uzbek government reorganized mahalla councils as bearers of "Uzbek nationhood" and "morality," effectively reproducing Soviet style state domination over the society. Thus, they are formal structures run by committees and once again regulated by

4148-513: The strictly negative or pejorative connotations of a slum or ghetto that are not present (or not as strongly implied) in other languages. A mahalla is an Islamic congregation or parish in Russia and a number of countries, once part of the Soviet Union . Typically, mahallas support a single mosque. An imam is seen as the spiritual head of the mahalla. Mahallas are directly subordinate to

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4216-411: The time from symptom onset to death has ranged from two to eight weeks. Prolonged prothrombin time and elevated C-reactive protein levels on admission to the hospital are associated with severe course of COVID-19 and with a transfer to intensive care units (ICU). Between 5% and 50% of COVID-19 patients experience long COVID , a condition characterised by long-term consequences persisting after

4284-694: The typical convalescence period of the disease. The most commonly reported clinical presentations are fatigue and memory problems, as well as malaise , headaches, shortness of breath , loss of smell, muscle weakness , low fever and cognitive dysfunction . Many countries attempted to slow or stop the spread of COVID-19 by recommending, mandating or prohibiting behaviour changes, while others relied primarily on providing information. Measures ranged from public advisories to stringent lockdowns. Outbreak control strategies are divided into elimination and mitigation. Experts differentiate between elimination strategies (known as " zero-COVID ") that aim to completely stop

4352-543: The variants were identified (e.g. Delta began as the " Indian variant") is no longer common. A more systematic naming scheme reflects the variant's PANGO lineage (e.g., Omicron 's lineage is B.1.1.529) and is used for other variants. SARS-CoV-2 is a virus closely related to bat coronaviruses , pangolin coronaviruses, and SARS-CoV . The first known outbreak (the 2019–2020 COVID-19 outbreak in mainland China ) started in Wuhan , Hubei, China, in December 2019. Many early cases were linked to people who had visited

4420-443: Was accidentally released from a laboratory have been proposed, as of 2021 these were not supported by evidence. Official "case" counts refer to the number of people who have been tested for COVID-19 and whose test has been confirmed positive according to official protocols whether or not they experienced symptomatic disease. Due to the effect of sampling bias , studies which obtain a more accurate number by extrapolating from

4488-457: Was still a pandemic. Pandemics and their ends are not well-defined, and whether or not one has ended differs according to the definition used. As of 24 November 2024, COVID-19 has caused 7,075,455 confirmed deaths. The COVID-19 pandemic ranks as the fifth- deadliest pandemic or epidemic in history . In epidemiology , a pandemic is defined as "an epidemic occurring over a very wide area, crossing international boundaries, and usually affecting

4556-509: Was the most widely used. According to a June 2022 study, COVID-19 vaccines prevented an additional 14.4 million to 19.8 million deaths in 185 countries and territories from 8 December 2020 to 8 December 2021. On 8 November 2022, the first recombinant protein-based COVID-19 vaccine (Novavax's booster Nuvaxovid ) was authorised for use in adults in the United Kingdom. It has subsequently received endorsement/authorisation from

4624-487: Was the smallest administrative entity. The mahalle was generally perceived to play an important role in identity formation , with the local mosque and the local coffee house as the main social gathering institutions. Mahalle lay at the intersection of private family life and the public sphere. Important community-level management functions were performed by mahalle solidarity, such as religious ceremonies, lifecycle rituals, resource management and conflict resolution. Today,

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