127-620: The timing hypothesis , gap hypothesis , gap theory , or critical window hypothesis for menopausal hormone therapy is a scientific theory that the benefits and risks of menopausal hormone therapy vary depending on the amount of time a woman has been in menopause upon initiation of treatment. More specifically, it is thought that hormone therapy may be protective against coronary heart disease in women who initiate it in early menopause but may be harmful in women who start it in late menopause. The timing hypothesis may also extend to risks of breast cancer and dementia with hormone therapy. It
254-406: A common ancestor . Acceptance of a theory does not require that all of its major predictions be tested, if it is already supported by sufficiently strong evidence. For example, certain tests may be unfeasible or technically difficult. As a result, theories may make predictions that have not yet been confirmed or proven incorrect; in this case, the predicted results may be described informally with
381-496: A scientific fact or scientific law in that a theory seeks to explain "why" or "how", whereas a fact is a simple, basic observation and a law is an empirical description of a relationship between facts and/or other laws. For example, Newton's Law of Gravity is a mathematical equation that can be used to predict the attraction between bodies, but it is not a theory to explain how gravity works. Stephen Jay Gould wrote that "...facts and theories are different things, not rungs in
508-443: A "root" metaphor that constrains how scientists theorize and model a phenomenon and thus arrive at testable hypotheses. Engineering practice makes a distinction between "mathematical models" and "physical models"; the cost of fabricating a physical model can be minimized by first creating a mathematical model using a computer software package, such as a computer aided design tool. The component parts are each themselves modelled, and
635-490: A DNA sequence within a chromosome is known as a locus . If the DNA sequence at a locus varies between individuals, the different forms of this sequence are called alleles. DNA sequences can change through mutations, producing new alleles. If a mutation occurs within a gene, the new allele may affect the trait that the gene controls, altering the phenotype of the organism. However, while this simple correspondence between an allele and
762-570: A GC-biased E. coli mutator strain in 1967, along with the proposal of the neutral theory , established the plausibility of mutational explanations for molecular patterns, which are now common in the molecular evolution literature. For instance, mutation biases are frequently invoked in models of codon usage. Such models also include effects of selection, following the mutation-selection-drift model, which allows both for mutation biases and differential selection based on effects on translation. Hypotheses of mutation bias have played an important role in
889-514: A chromosome becoming duplicated (usually by genetic recombination ), which can introduce extra copies of a gene into a genome. Extra copies of genes are a major source of the raw material needed for new genes to evolve. This is important because most new genes evolve within gene families from pre-existing genes that share common ancestors. For example, the human eye uses four genes to make structures that sense light: three for colour vision and one for night vision ; all four are descended from
1016-432: A direct result. The phrase " the received view of theories " is used to describe this approach. Terms commonly associated with it are " linguistic " (because theories are components of a language) and " syntactic " (because a language has rules about how symbols can be strung together). Problems in defining this kind of language precisely, e.g., are objects seen in microscopes observed or are they theoretical objects, led to
1143-534: A distance —Einstein presumed a gravitational field. In 1907, Einstein's equivalence principle implied that a free fall within a uniform gravitational field is equivalent to inertial motion. By extending special relativity's effects into three dimensions, general relativity extended length contraction into space contraction , conceiving of 4D space-time as the gravitational field that alters geometrically and sets all local objects' pathways. Even massless energy exerts gravitational motion on local objects by "curving"
1270-539: A fortiori , that has been) repeatedly tested and corroborated in accordance with the scientific method , using accepted protocols of observation , measurement, and evaluation of results. Where possible, theories are tested under controlled conditions in an experiment . In circumstances not amenable to experimental testing, theories are evaluated through principles of abductive reasoning . Established scientific theories have withstood rigorous scrutiny and embody scientific knowledge . A scientific theory differs from
1397-426: A graphical model that represents the territory of a city or country. In this approach, theories are a specific category of models that fulfill the necessary criteria (see above ). One can use language to describe a model; however, the theory is the model (or a collection of similar models), and not the description of the model. A model of the solar system, for example, might consist of abstract objects that represent
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#17328022111571524-465: A hierarchy of increasing certainty. Facts are the world's data. Theories are structures of ideas that explain and interpret facts." The meaning of the term scientific theory (often contracted to theory for brevity) as used in the disciplines of science is significantly different from the common vernacular usage of theory . In everyday speech, theory can imply an explanation that represents an unsubstantiated and speculative guess , whereas in
1651-402: A manner similar to a sequence of letters spelling out a sentence. Before a cell divides, the DNA is copied, so that each of the resulting two cells will inherit the DNA sequence. Portions of a DNA molecule that specify a single functional unit are called genes; different genes have different sequences of bases. Within cells, each long strand of DNA is called a chromosome . The specific location of
1778-474: A more accurate theory is then required. Some theories are so well-established that they are unlikely ever to be fundamentally changed (for example, scientific theories such as evolution , heliocentric theory , cell theory , theory of plate tectonics , germ theory of disease , etc.). In certain cases, a scientific theory or scientific law that fails to fit all data can still be useful (due to its simplicity) as an approximation under specific conditions. An example
1905-405: A nutrient in a long-term laboratory experiment , Flavobacterium evolving a novel enzyme that allows these bacteria to grow on the by-products of nylon manufacturing, and the soil bacterium Sphingobium evolving an entirely new metabolic pathway that degrades the synthetic pesticide pentachlorophenol . An interesting but still controversial idea is that some adaptations might increase
2032-611: A phenomenon termed de novo gene birth . The generation of new genes can also involve small parts of several genes being duplicated, with these fragments then recombining to form new combinations with new functions ( exon shuffling ). When new genes are assembled from shuffling pre-existing parts, domains act as modules with simple independent functions, which can be mixed together to produce new combinations with new and complex functions. For example, polyketide synthases are large enzymes that make antibiotics ; they contain up to 100 independent domains that each catalyse one step in
2159-538: A population are therefore more likely to be replaced by the offspring of parents with favourable characteristics for that environment. In the early 20th century, competing ideas of evolution were refuted and evolution was combined with Mendelian inheritance and population genetics to give rise to modern evolutionary theory. In this synthesis the basis for heredity is in DNA molecules that pass information from generation to generation. The processes that change DNA in
2286-575: A population include natural selection, genetic drift, mutation , and gene flow . All life on Earth—including humanity —shares a last universal common ancestor (LUCA), which lived approximately 3.5–3.8 billion years ago. The fossil record includes a progression from early biogenic graphite to microbial mat fossils to fossilised multicellular organisms . Existing patterns of biodiversity have been shaped by repeated formations of new species ( speciation ), changes within species ( anagenesis ), and loss of species ( extinction ) throughout
2413-430: A population is not critical, but instead a measure known as the effective population size. The effective population is usually smaller than the total population since it takes into account factors such as the level of inbreeding and the stage of the lifecycle in which the population is the smallest. The effective population size may not be the same for every gene in the same population. It is usually difficult to measure
2540-433: A population through neutral transitions due to the principles of excess capacity, presuppression, and ratcheting, and it has been applied in areas ranging from the origins of the spliceosome to the complex interdependence of microbial communities . The time it takes a neutral allele to become fixed by genetic drift depends on population size; fixation is more rapid in smaller populations. The number of individuals in
2667-499: A range of genes from bacteria, fungi and plants. Viruses can also carry DNA between organisms, allowing transfer of genes even across biological domains . Large-scale gene transfer has also occurred between the ancestors of eukaryotic cells and bacteria, during the acquisition of chloroplasts and mitochondria . It is possible that eukaryotes themselves originated from horizontal gene transfers between bacteria and archaea . Some heritable changes cannot be explained by changes to
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#17328022111572794-430: A reduction in scope when it was discovered that (1) GC-biased gene conversion makes an important contribution to composition in diploid organisms such as mammals and (2) bacterial genomes frequently have AT-biased mutation. Contemporary thinking about the role of mutation biases reflects a different theory from that of Haldane and Fisher. More recent work showed that the original "pressures" theory assumes that evolution
2921-410: A scale model of a house or of a solar system is clearly not an actual house or an actual solar system; the aspects of an actual house or an actual solar system represented in a scale model are, only in certain limited ways, representative of the actual entity. A scale model of a house is not a house; but to someone who wants to learn about houses, analogous to a scientist who wants to understand reality,
3048-415: A scientific context it most often refers to an explanation that has already been tested and is widely accepted as valid. The strength of a scientific theory is related to the diversity of phenomena it can explain and its simplicity. As additional scientific evidence is gathered, a scientific theory may be modified and ultimately rejected if it cannot be made to fit the new findings; in such circumstances,
3175-452: A single ancestral gene. New genes can be generated from an ancestral gene when a duplicate copy mutates and acquires a new function. This process is easier once a gene has been duplicated because it increases the redundancy of the system; one gene in the pair can acquire a new function while the other copy continues to perform its original function. Other types of mutations can even generate entirely new genes from previously noncoding DNA,
3302-419: A single chromosome compared to expectations , which is called their linkage disequilibrium . A set of alleles that is usually inherited in a group is called a haplotype . This can be important when one allele in a particular haplotype is strongly beneficial: natural selection can drive a selective sweep that will also cause the other alleles in the haplotype to become more common in the population; this effect
3429-420: A species or population, in particular shifts in allele frequency and adaptation. Macroevolution is the outcome of long periods of microevolution. Thus, the distinction between micro- and macroevolution is not a fundamental one—the difference is simply the time involved. However, in macroevolution, the traits of the entire species may be important. For instance, a large amount of variation among individuals allows
3556-544: A species to rapidly adapt to new habitats , lessening the chance of it going extinct, while a wide geographic range increases the chance of speciation, by making it more likely that part of the population will become isolated. In this sense, microevolution and macroevolution might involve selection at different levels—with microevolution acting on genes and organisms, versus macroevolutionary processes such as species selection acting on entire species and affecting their rates of speciation and extinction. A common misconception
3683-411: A striking example are people with the inherited trait of albinism , who do not tan at all and are very sensitive to sunburn . Heritable characteristics are passed from one generation to the next via DNA , a molecule that encodes genetic information. DNA is a long biopolymer composed of four types of bases. The sequence of bases along a particular DNA molecule specifies the genetic information, in
3810-420: A sufficiently detailed scale model may suffice. Several commentators have stated that the distinguishing characteristic of theories is that they are explanatory as well as descriptive, while models are only descriptive (although still predictive in a more limited sense). Philosopher Stephen Pepper also distinguished between theories and models, and said in 1948 that general models and theories are predicated on
3937-472: A system in which organisms interact with every other element, physical as well as biological , in their local environment. Eugene Odum , a founder of ecology, defined an ecosystem as: "Any unit that includes all of the organisms...in a given area interacting with the physical environment so that a flow of energy leads to clearly defined trophic structure, biotic diversity, and material cycles (i.e., exchange of materials between living and nonliving parts) within
Timing hypothesis (menopausal hormone therapy) - Misplaced Pages Continue
4064-542: A theory by finding even a single observation that disagrees with the predictions of the theory". Several philosophers and historians of science have, however, argued that Popper's definition of theory as a set of falsifiable statements is wrong because, as Philip Kitcher has pointed out, if one took a strictly Popperian view of "theory", observations of Uranus when first discovered in 1781 would have "falsified" Newton's celestial mechanics. Rather, people suggested that another planet influenced Uranus' orbit—and this prediction
4191-417: A theory does not require modification despite repeated tests, this implies that the theory is very accurate. This also means that accepted theories continue to accumulate evidence over time, and the length of time that a theory (or any of its principles) remains accepted often indicates the strength of its supporting evidence. In some cases, two or more theories may be replaced by a single theory that explains
4318-411: A theory is proposed and accepted, the previous theory will be retained. This is because it is still the best available explanation for many other phenomena, as verified by its predictive power in other contexts. For example, it has been known since 1859 that the observed perihelion precession of Mercury violates Newtonian mechanics, but the theory remained the best explanation available until relativity
4445-441: A theory must include statements that have observational consequences. But, like the observation of irregularities in the orbit of Uranus, falsification is only one possible consequence of observation. The production of new hypotheses is another possible and equally important result. The concept of a scientific theory has also been described using analogies and metaphors. For example, the logical empiricist Carl Gustav Hempel likened
4572-428: A trait works in some cases, most traits are influenced by multiple genes in a quantitative or epistatic manner. Evolution can occur if there is genetic variation within a population. Variation comes from mutations in the genome, reshuffling of genes through sexual reproduction and migration between populations ( gene flow ). Despite the constant introduction of new variation through mutation and gene flow, most of
4699-838: Is Newton's laws of motion , which are a highly accurate approximation to special relativity at velocities that are small relative to the speed of light . Scientific theories are testable and make verifiable predictions . They describe the causes of a particular natural phenomenon and are used to explain and predict aspects of the physical universe or specific areas of inquiry (for example, electricity, chemistry, and astronomy). As with other forms of scientific knowledge, scientific theories are both deductive and inductive , aiming for predictive and explanatory power . Scientists use theories to further scientific knowledge, as well as to facilitate advances in technology or medicine . Scientific hypotheses can never be "proven" because scientists are not able to fully confirm that their hypothesis
4826-454: Is directional selection , which is a shift in the average value of a trait over time—for example, organisms slowly getting taller. Secondly, disruptive selection is selection for extreme trait values and often results in two different values becoming most common, with selection against the average value. This would be when either short or tall organisms had an advantage, but not those of medium height. Finally, in stabilising selection there
4953-442: Is more noticeable . Indeed, the evolution of microorganisms is particularly important to evolutionary research since their rapid reproduction allows the study of experimental evolution and the observation of evolution and adaptation in real time. Adaptation is the process that makes organisms better suited to their habitat. Also, the term adaptation may refer to a trait that is important for an organism's survival. For example,
5080-427: Is a byproduct of this process that may sometimes be adaptively beneficial. Gene flow is the exchange of genes between populations and between species. It can therefore be a source of variation that is new to a population or to a species. Gene flow can be caused by the movement of individuals between separate populations of organisms, as might be caused by the movement of mice between inland and coastal populations, or
5207-617: Is a conjunction of ad- ("to, towards, at") and sumere (to take). The root survives, with shifted meanings, in the Italian assumere and Spanish sumir . The first sense of "assume" in the OED is "to take unto (oneself), receive, accept, adopt". The term was originally employed in religious contexts as in "to receive up into heaven", especially "the reception of the Virgin Mary into heaven, with body preserved from corruption", (1297 CE) but it
Timing hypothesis (menopausal hormone therapy) - Misplaced Pages Continue
5334-409: Is a good theory if it satisfies two requirements: It must accurately describe a large class of observations on the basis of a model that contains only a few arbitrary elements, and it must make definite predictions about the results of future observations." He also discusses the "unprovable but falsifiable" nature of theories, which is a necessary consequence of inductive logic, and that "you can disprove
5461-665: Is a statement that is accepted without evidence. For example, assumptions can be used as premises in a logical argument. Isaac Asimov described assumptions as follows: ...it is incorrect to speak of an assumption as either true or false, since there is no way of proving it to be either (If there were, it would no longer be an assumption). It is better to consider assumptions as either useful or useless, depending on whether deductions made from them corresponded to reality...Since we must start somewhere, we must have assumptions, but at least let us have as few assumptions as possible. Certain assumptions are necessary for all empirical claims (e.g.
5588-475: Is achieved. Since each new version of a theory (or a completely new theory) must have more predictive and explanatory power than the last, scientific knowledge consistently becomes more accurate over time. If modifications to the theory or other explanations seem to be insufficient to account for the new results, then a new theory may be required. Since scientific knowledge is usually durable, this occurs much less commonly than modification. Furthermore, until such
5715-587: Is also resolved by either further evidence or unification. For example, physical theories in the 19th century implied that the Sun could not have been burning long enough to allow certain geological changes as well as the evolution of life. This was resolved by the discovery of nuclear fusion , the main energy source of the Sun. Contradictions can also be explained as the result of theories approximating more fundamental (non-contradictory) phenomena. For example, atomic theory
5842-559: Is also tested, and if it fulfills the necessary criteria (see above), then the explanation becomes a theory. This can take many years, as it can be difficult or complicated to gather sufficient evidence. Once all of the criteria have been met, it will be widely accepted by scientists (see scientific consensus ) as the best available explanation of at least some phenomena. It will have made predictions of phenomena that previous theories could not explain or could not predict accurately, and it will have many repeated bouts of testing. The strength of
5969-593: Is an approximation of quantum mechanics . Current theories describe three separate fundamental phenomena of which all other theories are approximations; the potential unification of these is sometimes called the Theory of Everything . In 1905, Albert Einstein published the principle of special relativity , which soon became a theory. Special relativity predicted the alignment of the Newtonian principle of Galilean invariance , also termed Galilean relativity , with
6096-417: Is an inherited characteristic and an individual might inherit the "brown-eye trait" from one of their parents. Inherited traits are controlled by genes and the complete set of genes within an organism's genome (genetic material) is called its genotype . The complete set of observable traits that make up the structure and behaviour of an organism is called its phenotype . Some of these traits come from
6223-464: Is based on standing variation: when evolution depends on events of mutation that introduce new alleles, mutational and developmental biases in the introduction of variation (arrival biases) can impose biases on evolution without requiring neutral evolution or high mutation rates. Several studies report that the mutations implicated in adaptation reflect common mutation biases though others dispute this interpretation. Recombination allows alleles on
6350-434: Is both a theory and a fact . The logical positivists thought of scientific theories as statements in a formal language . First-order logic is an example of a formal language. The logical positivists envisaged a similar scientific language. In addition to scientific theories, the language also included observation sentences ("the sun rises in the east"), definitions, and mathematical statements. The phenomena explained by
6477-407: Is called deep homology . During evolution, some structures may lose their original function and become vestigial structures. Such structures may have little or no function in a current species, yet have a clear function in ancestral species, or other closely related species. Examples include pseudogenes , the non-functional remains of eyes in blind cave-dwelling fish, wings in flightless birds,
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#17328022111576604-692: Is called genetic hitchhiking or genetic draft. Genetic draft caused by the fact that some neutral genes are genetically linked to others that are under selection can be partially captured by an appropriate effective population size. A special case of natural selection is sexual selection, which is selection for any trait that increases mating success by increasing the attractiveness of an organism to potential mates. Traits that evolved through sexual selection are particularly prominent among males of several animal species. Although sexually favoured, traits such as cumbersome antlers, mating calls, large body size and bright colours often attract predation, which compromises
6731-594: Is measured by an organism's ability to survive and reproduce, which determines the size of its genetic contribution to the next generation. However, fitness is not the same as the total number of offspring: instead fitness is indicated by the proportion of subsequent generations that carry an organism's genes. For example, if an organism could survive well and reproduce rapidly, but its offspring were all too small and weak to survive, this organism would make little genetic contribution to future generations and would thus have low fitness. If an allele increases fitness more than
6858-411: Is potentially able to resolve conflicting findings between large observational studies and randomized controlled trials on long-term health outcomes with menopausal hormone therapy. This gynaecology article is a stub . You can help Misplaced Pages by expanding it . Scientific theory A scientific theory is an explanation of an aspect of the natural world and universe that can be (or
6985-421: Is selection against extreme trait values on both ends, which causes a decrease in variance around the average value and less diversity. This would, for example, cause organisms to eventually have a similar height. Natural selection most generally makes nature the measure against which individuals and individual traits, are more or less likely to survive. "Nature" in this sense refers to an ecosystem , that is,
7112-562: Is supported by a vast body of evidence. Many scientific theories are so well established that no new evidence is likely to alter them substantially. For example, no new evidence will demonstrate that the Earth does not orbit around the Sun (heliocentric theory), or that living things are not made of cells (cell theory), that matter is not composed of atoms, or that the surface of the Earth is not divided into solid plates that have moved over geological timescales (the theory of plate tectonics)...One of
7239-429: Is that evolution has goals, long-term plans, or an innate tendency for "progress", as expressed in beliefs such as orthogenesis and evolutionism; realistically, however, evolution has no long-term goal and does not necessarily produce greater complexity. Although complex species have evolved, they occur as a side effect of the overall number of organisms increasing, and simple forms of life still remain more common in
7366-664: Is that scientific theories are rudimentary ideas that will eventually graduate into scientific laws when enough data and evidence have been accumulated. A theory does not change into a scientific law with the accumulation of new or better evidence. A theory will always remain a theory; a law will always remain a law. Both theories and laws could potentially be falsified by countervailing evidence. Theories and laws are also distinct from hypotheses . Unlike hypotheses, theories and laws may be simply referred to as scientific fact . However, in science, theories are different from facts even when they are well supported. For example, evolution
7493-447: Is the nearly neutral theory , according to which a mutation that would be effectively neutral in a small population is not necessarily neutral in a large population. Other theories propose that genetic drift is dwarfed by other stochastic forces in evolution, such as genetic hitchhiking, also known as genetic draft. Another concept is constructive neutral evolution (CNE), which explains that complex systems can emerge and spread into
7620-495: Is the more common means of reproduction among eukaryotes and multicellular organisms. The Red Queen hypothesis has been used to explain the significance of sexual reproduction as a means to enable continual evolution and adaptation in response to coevolution with other species in an ever-changing environment. Another hypothesis is that sexual reproduction is primarily an adaptation for promoting accurate recombinational repair of damage in germline DNA, and that increased diversity
7747-439: Is the process by which traits that enhance survival and reproduction become more common in successive generations of a population. It embodies three principles: More offspring are produced than can possibly survive, and these conditions produce competition between organisms for survival and reproduction. Consequently, organisms with traits that give them an advantage over their competitors are more likely to pass on their traits to
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#17328022111577874-452: Is thought that the increase in breast cancer risk may be greater in women who start hormone therapy in early menopause but may be lower or that even decreased risk of breast cancer may occur in women who start in late menopause. The influence of hormone therapy on depressive symptoms may additionally be influenced by menopausal stage, with significant benefit seen in perimenopausal women but not in postmenopausal women. The timing hypothesis
8001-477: Is true. Instead, scientists say that the study "supports" or is consistent with their hypothesis. Albert Einstein described two different types of scientific theories: "Constructive theories" and "principle theories". Constructive theories are constructive models for phenomena: for example, kinetic theory . Principle theories are empirical generalisations, one such example being Newton's laws of motion . For any theory to be accepted within most academia there
8128-430: Is usually one simple criterion. The essential criterion is that the theory must be observable and repeatable. The aforementioned criterion is essential to prevent fraud and perpetuate science itself. The defining characteristic of all scientific knowledge, including theories, is the ability to make falsifiable or testable predictions . The relevance and specificity of those predictions determine how potentially useful
8255-402: The modern evolutionary synthesis , etc. In addition, most scientists prefer to work with a theory that meets the following qualities: The United States National Academy of Sciences defines scientific theories as follows: The formal scientific definition of theory is quite different from the everyday meaning of the word. It refers to a comprehensive explanation of some aspect of nature that
8382-425: The neutral theory of molecular evolution most evolutionary changes are the result of the fixation of neutral mutations by genetic drift. In this model, most genetic changes in a population are thus the result of constant mutation pressure and genetic drift. This form of the neutral theory has been debated since it does not seem to fit some genetic variation seen in nature. A better-supported version of this model
8509-454: The product of a gene , or prevent the gene from functioning, or have no effect. About half of the mutations in the coding regions of protein-coding genes are deleterious — the other half are neutral. A small percentage of the total mutations in this region confer a fitness benefit. Some of the mutations in other parts of the genome are deleterious but the vast majority are neutral. A few are beneficial. Mutations can involve large sections of
8636-519: The ability of organisms to generate genetic diversity and adapt by natural selection (increasing organisms' evolvability). Adaptation occurs through the gradual modification of existing structures. Consequently, structures with similar internal organisation may have different functions in related organisms. This is the result of a single ancestral structure being adapted to function in different ways. The bones within bat wings, for example, are very similar to those in mice feet and primate hands, due to
8763-402: The adaptation of horses' teeth to the grinding of grass. By using the term adaptation for the evolutionary process and adaptive trait for the product (the bodily part or function), the two senses of the word may be distinguished. Adaptations are produced by natural selection. The following definitions are due to Theodosius Dobzhansky: Adaptation may cause either the gain of a new feature, or
8890-523: The aether's properties. An elegant theory, special relativity yielded its own consequences, such as the equivalence of mass and energy transforming into one another and the resolution of the paradox that an excitation of the electromagnetic field could be viewed in one reference frame as electricity, but in another as magnetism. Einstein sought to generalize the invariance principle to all reference frames, whether inertial or accelerating. Rejecting Newtonian gravitation—a central force acting instantly at
9017-507: The alleles are subject to sampling error . This drift halts when an allele eventually becomes fixed, either by disappearing from the population or by replacing the other alleles entirely. Genetic drift may therefore eliminate some alleles from a population due to chance alone. Even in the absence of selective forces, genetic drift can cause two separate populations that begin with the same genetic structure to drift apart into two divergent populations with different sets of alleles. According to
9144-513: The assumption is valid, and does not make accurate predictions when the assumption is not valid. Such assumptions are often the point with which older theories are succeeded by new ones (the general theory of relativity works in non-inertial reference frames as well). The term "assumption" is actually broader than its standard use, etymologically speaking. The Oxford English Dictionary (OED) and online Wiktionary indicate its Latin source as assumere ("accept, to take to oneself, adopt, usurp"), which
9271-426: The assumption that reality exists). However, theories do not generally make assumptions in the conventional sense (statements accepted without evidence). While assumptions are often incorporated during the formation of new theories, these are either supported by evidence (such as from previously existing theories) or the evidence is produced in the course of validating the theory. This may be as simple as observing that
9398-441: The biosphere. For example, the overwhelming majority of species are microscopic prokaryotes , which form about half the world's biomass despite their small size and constitute the vast majority of Earth's biodiversity. Simple organisms have therefore been the dominant form of life on Earth throughout its history and continue to be the main form of life up to the present day, with complex life only appearing more diverse because it
9525-488: The change over time in this genetic variation. The frequency of one particular allele will become more or less prevalent relative to other forms of that gene. Variation disappears when a new allele reaches the point of fixation —when it either disappears from the population or replaces the ancestral allele entirely. Mutations are changes in the DNA sequence of a cell's genome and are the ultimate source of genetic variation in all organisms. When mutations occur, they may alter
9652-492: The contemporary standard sense of "that which is assumed or taken for granted; a supposition, postulate" (only the 11th of 12 senses of "assumption", and the 10th of 11 senses of "assume"). Karl Popper described the characteristics of a scientific theory as follows: Popper summarized these statements by saying that the central criterion of the scientific status of a theory is its "falsifiability, or refutability, or testability". Echoing this, Stephen Hawking states, "A theory
9779-403: The descent of all these structures from a common mammalian ancestor. However, since all living organisms are related to some extent, even organs that appear to have little or no structural similarity, such as arthropod , squid and vertebrate eyes, or the limbs and wings of arthropods and vertebrates, can depend on a common set of homologous genes that control their assembly and function; this
9906-400: The development of thinking about the evolution of genome composition, including isochores. Different insertion vs. deletion biases in different taxa can lead to the evolution of different genome sizes. The hypothesis of Lynch regarding genome size relies on mutational biases toward increase or decrease in genome size. However, mutational hypotheses for the evolution of composition suffered
10033-490: The direct control of genes include the inheritance of cultural traits and symbiogenesis . From a neo-Darwinian perspective, evolution occurs when there are changes in the frequencies of alleles within a population of interbreeding organisms, for example, the allele for black colour in a population of moths becoming more common. Mechanisms that can lead to changes in allele frequencies include natural selection, genetic drift, and mutation bias. Evolution by natural selection
10160-400: The effective demise of logical positivism in the 1970s. The semantic view of theories , which identifies scientific theories with models rather than propositions , has replaced the received view as the dominant position in theory formulation in the philosophy of science. A model is a logical framework intended to represent reality (a "model of reality"), similar to the way that a map is
10287-586: The electromagnetic field. By omitting from special relativity the luminiferous aether , Einstein stated that time dilation and length contraction measured in an object in relative motion is inertial —that is, the object exhibits constant velocity , which is speed with direction , when measured by its observer. He thereby duplicated the Lorentz transformation and the Lorentz contraction that had been hypothesized to resolve experimental riddles and inserted into electrodynamic theory as dynamical consequences of
10414-534: The evidence is evaluated by the scientific community, and the most important experiments will have been replicated by multiple independent groups. Theories do not have to be perfectly accurate to be scientifically useful. For example, the predictions made by classical mechanics are known to be inaccurate in the relativistic realm, but they are almost exactly correct at the comparatively low velocities of common human experience. In chemistry , there are many acid-base theories providing highly divergent explanations of
10541-489: The evolutionary history of life on Earth. Morphological and biochemical traits tend to be more similar among species that share a more recent common ancestor , which historically was used to reconstruct phylogenetic trees , although direct comparison of genetic sequences is a more common method today. Evolutionary biologists have continued to study various aspects of evolution by forming and testing hypotheses as well as constructing theories based on evidence from
10668-446: The experimental design was sound, and if so they confirm the results by independent replication . A search for potential improvements to the theory then begins. Solutions may require minor or major changes to the theory, or none at all if a satisfactory explanation is found within the theory's existing framework. Over time, as successive modifications build on top of each other, theories consistently improve and greater predictive accuracy
10795-557: The fabrication tolerances are specified. An exploded view drawing is used to lay out the fabrication sequence. Simulation packages for displaying each of the subassemblies allow the parts to be rotated, magnified, in realistic detail. Software packages for creating the bill of materials for construction allows subcontractors to specialize in assembly processes, which spreads the cost of manufacturing machinery among multiple customers. See: Computer-aided engineering , Computer-aided manufacturing , and 3D printing An assumption (or axiom )
10922-414: The field or laboratory and on data generated by the methods of mathematical and theoretical biology . Their discoveries have influenced not just the development of biology but also other fields including agriculture, medicine, and computer science . Evolution in organisms occurs through changes in heritable characteristics—the inherited characteristics of an organism. In humans, for example, eye colour
11049-427: The fitness of an allele is not a fixed characteristic; if the environment changes, previously neutral or harmful traits may become beneficial and previously beneficial traits become harmful. However, even if the direction of selection does reverse in this way, traits that were lost in the past may not re-evolve in an identical form. However, a re-activation of dormant genes, as long as they have not been eliminated from
11176-472: The genome and were only suppressed perhaps for hundreds of generations, can lead to the re-occurrence of traits thought to be lost like hindlegs in dolphins, teeth in chickens, wings in wingless stick insects, tails and additional nipples in humans etc. "Throwbacks" such as these are known as atavisms . Natural selection within a population for a trait that can vary across a range of values, such as height, can be categorised into three different types. The first
11303-479: The genome of a species is very similar among all individuals of that species. However, discoveries in the field of evolutionary developmental biology have demonstrated that even relatively small differences in genotype can lead to dramatic differences in phenotype both within and between species. An individual organism's phenotype results from both its genotype and the influence of the environment it has lived in. The modern evolutionary synthesis defines evolution as
11430-545: The geometrical "surface" of 4D space-time. Yet unless the energy is vast, its relativistic effects of contracting space and slowing time are negligible when merely predicting motion. Although general relativity is embraced as the more explanatory theory via scientific realism , Newton's theory remains successful as merely a predictive theory via instrumentalism . To calculate trajectories, engineers and NASA still uses Newton's equations, which are simpler to operate. Both scientific laws and scientific theories are produced from
11557-640: The idea of developmental bias . Haldane and Fisher argued that, because mutation is a weak pressure easily overcome by selection, tendencies of mutation would be ineffectual except under conditions of neutral evolution or extraordinarily high mutation rates. This opposing-pressures argument was long used to dismiss the possibility of internal tendencies in evolution, until the molecular era prompted renewed interest in neutral evolution. Noboru Sueoka and Ernst Freese proposed that systematic biases in mutation might be responsible for systematic differences in genomic GC composition between species. The identification of
11684-450: The interaction of its genotype with the environment while others are neutral. Some observable characteristics are not inherited. For example, suntanned skin comes from the interaction between a person's genotype and sunlight; thus, suntans are not passed on to people's children. The phenotype is the ability of the skin to tan when exposed to sunlight. However, some people tan more easily than others, due to differences in genotypic variation;
11811-512: The level of the individual organism are genes called transposons , which can replicate and spread throughout a genome. Selection at a level above the individual, such as group selection , may allow the evolution of cooperation. Genetic drift is the random fluctuation of allele frequencies within a population from one generation to the next. When selective forces are absent or relatively weak, allele frequencies are equally likely to drift upward or downward in each successive generation because
11938-452: The longer term, evolution produces new species through splitting ancestral populations of organisms into new groups that cannot or will not interbreed. These outcomes of evolution are distinguished based on time scale as macroevolution versus microevolution. Macroevolution refers to evolution that occurs at or above the level of species, in particular speciation and extinction, whereas microevolution refers to smaller evolutionary changes within
12065-405: The loss of an ancestral feature. An example that shows both types of change is bacterial adaptation to antibiotic selection, with genetic changes causing antibiotic resistance by both modifying the target of the drug, or increasing the activity of transporters that pump the drug out of the cell. Other striking examples are the bacteria Escherichia coli evolving the ability to use citric acid as
12192-458: The mechanics in developmental plasticity and canalisation . Heritability may also occur at even larger scales. For example, ecological inheritance through the process of niche construction is defined by the regular and repeated activities of organisms in their environment. This generates a legacy of effects that modify and feed back into the selection regime of subsequent generations. Other examples of heritability in evolution that are not under
12319-622: The most useful properties of scientific theories is that they can be used to make predictions about natural events or phenomena that have not yet been observed. From the American Association for the Advancement of Science : A scientific theory is a well-substantiated explanation of some aspect of the natural world, based on a body of facts that have been repeatedly confirmed through observation and experiment. Such fact-supported theories are not "guesses" but reliable accounts of
12446-408: The movement of pollen between heavy-metal-tolerant and heavy-metal-sensitive populations of grasses. Gene transfer between species includes the formation of hybrid organisms and horizontal gene transfer . Horizontal gene transfer is the transfer of genetic material from one organism to another organism that is not its offspring; this is most common among bacteria. In medicine, this contributes to
12573-427: The next generation than those with traits that do not confer an advantage. This teleonomy is the quality whereby the process of natural selection creates and preserves traits that are seemingly fitted for the functional roles they perform. Consequences of selection include nonrandom mating and genetic hitchhiking . The central concept of natural selection is the evolutionary fitness of an organism. Fitness
12700-499: The offspring of sexual organisms contain random mixtures of their parents' chromosomes that are produced through independent assortment. In a related process called homologous recombination , sexual organisms exchange DNA between two matching chromosomes. Recombination and reassortment do not alter allele frequencies, but instead change which alleles are associated with each other, producing offspring with new combinations of alleles. Sex usually increases genetic variation and may increase
12827-456: The other alleles of that gene, then with each generation this allele has a higher probability of becoming common within the population. These traits are said to be "selected for ." Examples of traits that can increase fitness are enhanced survival and increased fecundity . Conversely, the lower fitness caused by having a less beneficial or deleterious allele results in this allele likely becoming rarer—they are "selected against ." Importantly,
12954-578: The overall process, like a step in an assembly line. One example of mutation is wild boar piglets. They are camouflage coloured and show a characteristic pattern of dark and light longitudinal stripes. However, mutations in the melanocortin 1 receptor ( MC1R ) disrupt the pattern. The majority of pig breeds carry MC1R mutations disrupting wild-type colour and different mutations causing dominant black colouring. In asexual organisms, genes are inherited together, or linked , as they cannot mix with genes of other organisms during reproduction. In contrast,
13081-426: The planets. For most planets, the Newtonian model's predictions are accurate; for Mercury , it is slightly inaccurate and the model of general relativity must be used instead. The word " semantic " refers to the way that a model represents the real world. The representation (literally, "re-presentation") describes particular aspects of a phenomenon or the manner of interaction among a set of phenomena. For instance,
13208-527: The presence of hip bones in whales and snakes, and sexual traits in organisms that reproduce via asexual reproduction. Examples of vestigial structures in humans include wisdom teeth , the coccyx , the vermiform appendix , and other behavioural vestiges such as goose bumps and primitive reflexes . However, many traits that appear to be simple adaptations are in fact exaptations : structures originally adapted for one function, but which coincidentally became somewhat useful for some other function in
13335-413: The previous theories as approximations or special cases, analogous to the way a theory is a unifying explanation for many confirmed hypotheses; this is referred to as unification of theories. For example, electricity and magnetism are now known to be two aspects of the same phenomenon, referred to as electromagnetism . When the predictions of different theories appear to contradict each other, this
13462-469: The process. One example is the African lizard Holaspis guentheri , which developed an extremely flat head for hiding in crevices, as can be seen by looking at its near relatives. However, in this species, the head has become so flattened that it assists in gliding from tree to tree—an exaptation. Within cells, molecular machines such as the bacterial flagella and protein sorting machinery evolved by
13589-463: The proposal and testing of hypotheses , by deriving predictions from the hypotheses about the results of future experiments, then performing those experiments to see whether the predictions are valid. This provides evidence either for or against the hypothesis. When enough experimental results have been gathered in a particular area of inquiry, scientists may propose an explanatory framework that accounts for as many of these as possible. This explanation
13716-494: The rate of evolution. The two-fold cost of sex was first described by John Maynard Smith . The first cost is that in sexually dimorphic species only one of the two sexes can bear young. This cost does not apply to hermaphroditic species, like most plants and many invertebrates . The second cost is that any individual who reproduces sexually can only pass on 50% of its genes to any individual offspring, with even less passed on as each new generation passes. Yet sexual reproduction
13843-483: The real world. The theory of biological evolution is more than "just a theory". It is as factual an explanation of the universe as the atomic theory of matter or the germ theory of disease. Our understanding of gravity is still a work in progress. But the phenomenon of gravity, like evolution, is an accepted fact. Note that the term theory would not be appropriate for describing untested but intricate hypotheses or even scientific models. The scientific method involves
13970-408: The relative importance of selection and neutral processes, including drift. The comparative importance of adaptive and non-adaptive forces in driving evolutionary change is an area of current research . Mutation bias is usually conceived as a difference in expected rates for two different kinds of mutation, e.g., transition-transversion bias, GC-AT bias, deletion-insertion bias. This is related to
14097-417: The same strand of DNA to become separated. However, the rate of recombination is low (approximately two events per chromosome per generation). As a result, genes close together on a chromosome may not always be shuffled away from each other and genes that are close together tend to be inherited together, a phenomenon known as linkage . This tendency is measured by finding how often two alleles occur together on
14224-578: The scientific method through the formation and testing of hypotheses, and can predict the behavior of the natural world. Both are also typically well-supported by observations and/or experimental evidence. However, scientific laws are descriptive accounts of how nature will behave under certain conditions. Scientific theories are broader in scope, and give overarching explanations of how nature works and why it exhibits certain characteristics. Theories are supported by evidence from many different sources, and may contain one or several laws. A common misconception
14351-552: The sequence of nucleotides in the DNA. These phenomena are classed as epigenetic inheritance systems. DNA methylation marking chromatin , self-sustaining metabolic loops, gene silencing by RNA interference and the three-dimensional conformation of proteins (such as prions ) are areas where epigenetic inheritance systems have been discovered at the organismic level. Developmental biologists suggest that complex interactions in genetic networks and communication among cells can lead to heritable variations that may underlay some of
14478-406: The spread of antibiotic resistance , as when one bacteria acquires resistance genes it can rapidly transfer them to other species. Horizontal transfer of genes from bacteria to eukaryotes such as the yeast Saccharomyces cerevisiae and the adzuki bean weevil Callosobruchus chinensis has occurred. An example of larger-scale transfers are the eukaryotic bdelloid rotifers , which have received
14605-602: The structure of a scientific theory to a "complex spatial network:" Evolution Evolution is the change in the heritable characteristics of biological populations over successive generations. It occurs when evolutionary processes such as natural selection and genetic drift act on genetic variation, resulting in certain characteristics becoming more or less common within a population over successive generations. The process of evolution has given rise to biodiversity at every level of biological organisation . The scientific theory of evolution by natural selection
14732-419: The sun and the planets. These objects have associated properties, e.g., positions, velocities, and masses. The model parameters, e.g., Newton's Law of Gravitation, determine how the positions and velocities change with time. This model can then be tested to see whether it accurately predicts future observations; astronomers can verify that the positions of the model's objects over time match the actual positions of
14859-640: The survival of individual males. This survival disadvantage is balanced by higher reproductive success in males that show these hard-to-fake , sexually selected traits. Evolution influences every aspect of the form and behaviour of organisms. Most prominent are the specific behavioural and physical adaptations that are the outcome of natural selection. These adaptations increase fitness by aiding activities such as finding food, avoiding predators or attracting mates. Organisms can also respond to selection by cooperating with each other, usually by aiding their relatives or engaging in mutually beneficial symbiosis . In
14986-642: The system...." Each population within an ecosystem occupies a distinct niche , or position, with distinct relationships to other parts of the system. These relationships involve the life history of the organism, its position in the food chain and its geographic range. This broad understanding of nature enables scientists to delineate specific forces which, together, comprise natural selection. Natural selection can act at different levels of organisation , such as genes, cells, individual organisms, groups of organisms and species. Selection can act at multiple levels simultaneously. An example of selection occurring below
15113-420: The term "theoretical". These predictions can be tested at a later time, and if they are incorrect, this may lead to the revision or rejection of the theory.As Feynman puts it: It doesn't matter how beautiful your theory is, it doesn't matter how smart you are. If it doesn't agree with experiment, it's wrong. If experimental results contrary to a theory's predictions are observed, scientists first evaluate whether
15240-477: The theories, if they could not be directly observed by the senses (for example, atoms and radio waves ), were treated as theoretical concepts. In this view, theories function as axioms : predicted observations are derived from the theories much like theorems are derived in Euclidean geometry . However, the predictions are then tested against reality to verify the predictions, and the "axioms" can be revised as
15367-480: The theory is. A would-be theory that makes no observable predictions is not a scientific theory at all. Predictions not sufficiently specific to be tested are similarly not useful. In both cases, the term "theory" is not applicable. A body of descriptions of knowledge can be called a theory if it fulfills the following criteria: These qualities are certainly true of such established theories as special and general relativity , quantum mechanics , plate tectonics ,
15494-449: The theory makes accurate predictions, which is evidence that any assumptions made at the outset are correct or approximately correct under the conditions tested. Conventional assumptions, without evidence, may be used if the theory is only intended to apply when the assumption is valid (or approximately valid). For example, the special theory of relativity assumes an inertial frame of reference . The theory makes accurate predictions when
15621-498: The underlying nature of acidic and basic compounds, but they are very useful for predicting their chemical behavior. Like all knowledge in science, no theory can ever be completely certain , since it is possible that future experiments might conflict with the theory's predictions. However, theories supported by the scientific consensus have the highest level of certainty of any scientific knowledge; for example, that all objects are subject to gravity or that life on Earth evolved from
15748-540: Was also simply used to refer to "receive into association" or "adopt into partnership". Moreover, other senses of assumere included (i) "investing oneself with (an attribute)", (ii) "to undertake" (especially in Law), (iii) "to take to oneself in appearance only, to pretend to possess", and (iv) "to suppose a thing to be" (all senses from OED entry on "assume"; the OED entry for "assumption" is almost perfectly symmetrical in senses). Thus, "assumption" connotes other associations than
15875-895: Was conceived independently by two British naturalists, Charles Darwin and Alfred Russel Wallace , in the mid-19th century as an explanation for why organisms are adapted to their physical and biological environments. The theory was first set out in detail in Darwin's book On the Origin of Species . Evolution by natural selection is established by observable facts about living organisms: (1) more offspring are often produced than can possibly survive; (2) traits vary among individuals with respect to their morphology , physiology , and behaviour; (3) different traits confer different rates of survival and reproduction (differential fitness ); and (4) traits can be passed from generation to generation ( heritability of fitness). In successive generations, members of
16002-627: Was indeed eventually confirmed. Kitcher agrees with Popper that "There is surely something right in the idea that a science can succeed only if it can fail." He also says that scientific theories include statements that cannot be falsified, and that good theories must also be creative. He insists we view scientific theories as an "elaborate collection of statements", some of which are not falsifiable, while others—those he calls "auxiliary hypotheses", are. According to Kitcher, good scientific theories must have three features: Like other definitions of theories, including Popper's, Kitcher makes it clear that
16129-443: Was supported by sufficient evidence. Also, while new theories may be proposed by a single person or by many, the cycle of modifications eventually incorporates contributions from many different scientists. After the changes, the accepted theory will explain more phenomena and have greater predictive power (if it did not, the changes would not be adopted); this new explanation will then be open to further replacement or modification. If
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