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73-607: Many leading scientists joined G.I. from academia and it proved to be a fertile source of patents for some time. One of the two largest national clusters of biotechnology in the U.S. (the other being the San Francisco Bay area), the greater Boston area has been the birthplace of many innovative corporations and non-profit research centers. Beginning in the late 1970s and 1980s, this biotech trend saw three early large for-profit corporations: Biogen (now Biogen Idec), Genzyme , and Genetics Institute. MIT's Whitehead Institute

146-550: A closed-end fund. On October 23, Align Technology replaced Mattel in the index. On December 8, Nasdaq announced that five companies would enter the index on December 18. They were ASML Holding , Cadence Design Systems , Synopsys , Take-Two Interactive and Workday These companies replaced Akamai Technologies, Discovery Communications – both classes listed in the index (DISCA) (DISCK), Norwegian Cruise Lines, Tractor Supply and Viacom. On July 23, PepsiCo replaced Dish Network . On November 5, NXP Semiconductors rejoined

219-729: A component of the index, replacing Teva Pharmaceutical Industries , which transferred to the NYSE. On July 23, 2012, Kraft Foods , now known as Mondelez , became a component of the index, replacing Ctrip . Kraft Foods was the fourth component of the Nasdaq-100 to also be included in the Dow Jones Industrial Average , joining Cisco , Intel and Microsoft, but was removed from the DJIA when it subsequently split into two companies. On Wednesday December 12, 2012, Facebook, Inc

292-652: A global licensing deal to develop compounds for neuromuscular and neurological diseases. In September 2020, Biogen Inc. made a $ 10 million deposit in OneUnited Bank to provide more capital to fund home loans and commercial development in Black communities. In November, the company announced it would acquire a $ 650 million stake in Cambridge-based Sage Therapeutics and make an upfront payment of $ 875 million, in order to jointly develop

365-799: A number of depression treatments. In July 2023, it was announced Biogen had acquired the Plano, Texas -headquartered biotech company, Reata Pharmaceuticals for nearly $ 6.5 billion. In May 2024, Biogen acquired Human Immunology Biosciences (HI-Bio) for $ 1.15 billion. In 2007, the company reached a licensing agreement with Neurimmune, a spin-off from the University of Zurich, for the Alzheimer's disease drug, Aducanumab , developed by this Swiss company. Later, Neurimmune sold its rights for license fees for $ 200 million to Biogen. In December 2014, Biogen announced that Aducanumab for Alzheimer's treatment

438-469: A setback in their drug research, Biogen's shares fell sharply that same month. It ended the trial of Aducanumab, which it was making along with Eisai . In October 2019, however, they announced that they would pursue FDA approval together with Eisai. On October 22, 2019, despite two Phase 3 clinical trials being previously halted for futility, Biogen announced its plan to submit for FDA's approval of Aducanumab. In May 2020, Biogen wrapped up construction on

511-550: A spinoff. On March 18, 2013, Kraft Foods replaced Starz. On June 5, 2013, Liberty Media replaced Virgin Media after the companies merged. On June 6, 2013, Netflix replaced Perrigo , which had transferred to the NYSE. On July 15, 2013, Tesla Motors replaced Oracle , which transferred to the NYSE. On July 25, Charter Communications replaced BMC Software . On August 22, Green Mountain Coffee Roasters returned to

584-616: A state-of-the-art facility in Solothurn , Switzerland , which will produce Aducanumab by late 2021, alongside its North Carolina manufacturing facility. The monoclonal antibody , co-developed with Eisai , attracted considerable interest from biotech investors when Warren Buffett 's Berkshire Hathaway bought 648,447 Biogen shares at a combined value of $ 192.4 million. On July 8, 2020, Biogen and Eisai announced that both companies had together successfully submitted for Aducanumab's FDA regulatory and marketing approval. On June 7, 2021,

657-614: A treatment for Spinal Muscular Atrophy. The drug is among the most expensive treatments available, with a price of $ 750,000 for the first year of doses, and $ 375,000 for each subsequent year and likely for the rest of a patient's life. While there still isn't a cure, Spinraza significantly improves the quality of life in infants and adults. In 2017, Biogen announced that its drug Fampyra converted from conditional marketing authorization to standard marketing approval. EU multiple sclerosis (MS) patients use Fampyra to improve walking. In February 2020, Biogen and Sangamo Therapeutics announced

730-526: Is not a comprehensive list): On March 5, 2020, Biogen reported that three individuals who met with their employees at a conference in Boston had tested positive for COVID-19 the previous week. On March 6, public health officials reported five new cases associated with the Biogen leadership meeting and by March 9, Massachusetts health officials had announced 30 new presumptive COVID-19 cases, all connected to

803-487: Is one of the drug's producers. In 2011, Biogen announced that its drug Fampyra received conditional marketing approval . Under the conditional approval, Biogen agrees to provide additional data on the long-term benefits and safety of Fampyra. On December 10, 2012, Biogen announced its global collaboration agreement with Isis Pharmaceuticals to develop and research antisense drugs to treat neurological and neuromuscular diseases . In February 2013, Bloomberg broke

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876-605: Is rebalanced quarterly only if: The index is rebalanced annually, after the quarterly rebalancing, only if: In addition to its almost complete lack of financial companies, the Nasdaq-100 includes seven companies incorporated outside the United States. Although the S&;P 500 Index includes non-U.S. companies, the Dow Jones Industrial Average has never included foreign companies. As of June 2024,

949-510: The FDA gave accelerated approval to Aducanumab under the name Aduhelm, which proved to be controversial. The drug was priced at $ 56,000 US dollars per year, but it was not covered by many insurers as they awaited further proof that the drug was effective. The US Government did not subsidise it outside clinical trials. According to the FDA's website, the drug was proven to reduce amyloid-beta plaques in

1022-508: The Federal Reserve and optimism that the financial crisis was ending, the index embarked on a volatile four-year climb higher, closing above 3,000 on May 15, 2013, for the first time since November 15, 2000. By October 18, 2013, with GOOG passing $ 1,000 per share for the first time, the index had made a closing high of 3,353.88 and intraday high of 3,355.63, its highest levels since the 2000 United States elections and more than triple

1095-578: The Nasdaq Financial-100 . The Nasdaq-100 was launched on January 31, 1985, by the Nasdaq. It created two indices: the Nasdaq-100, which consists of Industrial , Technology , Retail , Telecommunication , Biotechnology , Health Care , Transportation , Media and Service companies, and the Nasdaq Financial-100 , which consists of banking companies , insurance firms , brokerage firms , and Mortgage loan companies. The base price of

1168-940: The University of Zurich (Weissmann contributed the first product interferon alpha ). Gilbert and Sharp were subsequently honored with Nobel Prizes : Gilbert was recognized in 1980 with the Nobel Prize in Chemistry for his understanding of DNA sequencing and Sharp received the Nobel Prize in Physiology or Medicine in 1993 for his discovery of split genes . In 2003, Biogen merged with San Diego, California -based IDEC Pharmaceuticals (formed in 1985 by University of California-San Diego 's physicians and immunologists Ivor Royston and Robert E. Sobol, San Diego bio entrepreneur Howard Birndorf , and Stanford University cancer researchers Ron Levy and Richard Miller) and adopted

1241-552: The late-2000s recession , the United States housing bubble and the financial crisis of 2007–2008 . Panic focusing on the failure of the investment banking industry culminated in a loss of more than 10% on September 29, 2008, subsequently plunging the index firmly into a bear market . The Nasdaq-100, with much of the broader market, experienced a limit down open on October 24 and reached a 6-year intraday low of 1,018 on November 20, 2008. Amid quantitative easing (QE) from

1314-448: The 2008 low. The following table shows the annual development of the Nasdaq-100 since 1985. The Nasdaq has refined a series of stringent standards which companies must meet to be indexed. Those standards include: Additionally, since 2014, companies with multiple classes of stock are allowed to have multiple classes included in the index, provided they meet Nasdaq's criteria. Prior to 2014, companies were limited to one class of stock in

1387-444: The Biogen conference. Researchers first estimated that the conference would be linked to over 20,000 of the state's coronavirus cases. Researchers later estimated that up to 300,000 cases worldwide had been caused by the Biogen conference, including 1.6% of all U.S. cases of the coronavirus. For the fiscal year 2017, Biogen reported earnings of US$ 2.539 billion, with an annual revenue of US$ 12.274 billion, an increase of 7.2% over

1460-478: The Class C common stock of Google was added to the index as a result of Google's stock split. This meant the index had 101 components. Later in 2014, additional classes of stock from other index companies were added to the index, bringing the number of constituent securities in the index to 107. On December 12, 2014, Nasdaq announced that American Airlines Group , Electronic Arts and Lam Research would be added to

1533-453: The FDA voted against approval of this drug. On June 7, 2021, the FDA granted approval of Aducanumab for the treatment of Alzheimer's disease. Aducanumab was approved using the accelerated approval pathway, and Biogen will be required to conduct a post-approval clinical trial to verify clinical benefit for continued approval. NASDAQ-100 The Nasdaq-100 ( ^NDX ) is a stock market index made up of equity securities issued by 100 of

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1606-526: The Nasdaq-100 Ex-Tech, which follows those components that are not considered tech companies. The latter index includes noted e-commerce companies Amazon.com and eBay , which are classified as retailers. This table is current as of the open of trading on June 24, 2024. An up-to-date list is available in the External links section. As of July 2024, 514 companies have been components of

1679-475: The Nasdaq-100 Index Trust, which holds portions of all Nasdaq-100 firms. The new methodology allowed Nasdaq to reduce the influence of the largest companies and to allow for more diversification. However, the weights of the stocks were not changed after that, which led to more problems. In May 2011, Nasdaq did a major rebalance of the index to bring it closer to market-cap weighting. The index

1752-511: The Nasdaq-100 in January 1998, but had higher standards to meet before they could be added. Those standards were relaxed in 2002, while standards for domestic firms were raised, ensuring that all companies met the same standards. The Invesco QQQ , an exchange-traded fund sponsored and overseen since March 21, 2007, by Invesco , trades under the ticker Nasdaq :  QQQ . It was formerly called Nasdaq-100 Trust Series 1. On December 1, 2004, it

1825-637: The Nasdaq-100. With some exceptions, most stocks that are added to the index come up through the Q-50. In 2011, Nasdaq created the NASDAQ-500 to track the 500 largest stocks on Nasdaq, and the Nasdaq-400, tracking those stocks not included in the Nasdaq-100. Nasdaq has also divided the 100 into two distinct sub-indices; the Nasdaq-100 Tech follows those components who service the tech sector, and

1898-401: The brain, which was likely to benefit patients. The FDA has stated that if the post-approval trial did not indicate that Aduhelm works, the drug may be taken out of the market. Biogen abandoned the drug in January 2024, for financial reasons. In May 2016, the company announced that it would spin off its hemophilia drug business ( Eloctate and Alprolix ) into a public company. In August,

1971-531: The brains of people with early-stage Alzheimer's disease, according to a report published in Nature on August 31, 2016. On March 21, 2019, Biogen announced that the Phase 3 clinical trials of Aducanumab were halted. Biogen announced it would acquire Nightstar Therapeutics for $ 25.50 per share ($ 800 million in total). Nightstar focused on adeno-associated virus based gene-therapies for inherited retinal disorders. With

2044-417: The code NQ. Both are among the most heavily traded futures at the exchange. The index set highs above the 4,700 level at the peak of the dot-com bubble in 2000, but fell 78% during the stock market downturn of 2002 . After a gradual 5-year recovery to an intraday high of 2,239.51 on October 31, 2007, the highest reached since February 16, 2002, the index corrected below the 2,000 level in early 2008 amid

2117-484: The company announced it would acquire Syntonix Pharmaceuticals for up to $ 120 million, gaining Syntonix's lead product for hemophilia B as well as the technology for developing inhalable treatments. In 2008, two new brain infection cases from Tysabri users surfaced in Europe that raised international concern about Tysabri and its effects with the progressive multifocal leukoencephalopathy (PML) brain condition. Biogen

2190-457: The company announced that the spun off company would be called Bioverativ , in order to show heritage with Biogen. The company would trade on the NASDAQ exchange under the ticker symbol BIVV and would look to be spun off in early 2017. Bioverativ was acquired by Sanofi in 2018. The following is an illustration of the company's major mergers and acquisitions and historical predecessors (this

2263-594: The company's interests in Latin America. Both tracking stocks were added to the index the same day. On July 2, Kraft Foods merged with Heinz , becoming Kraft Heinz . Catamaran Corporation was removed from the index after the close of trading on July 23, after going private. JD.com replaced it on July 29. DirecTV was removed from the index on July 24 due to its acquisition by AT&T and replaced by BioMarin Pharmaceutical on July 27. Sigma-Aldrich

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2336-547: The development and commercialization of ALPROLIX. Commercialized in the United States as AMPYRA (dalfampridine) Extended Release Tablets, by Acorda Therapeutics . Acquired in acquisition of Fumapharm AG in 2006. Currently commercialized in the United States by Genentech, a wholly owned subsidiary of Roche. Anti-TNF Refractory Rheumatoid Arthritis ANCA-Associated Vasculitis Chronic lymphocytic leukemia 2006 2011 Currently commercialized by Roche and its subsidiary, Genentech. Biogen focused its R&D efforts on

2409-589: The development of Convergence's pipeline, in particular CNV1014802 – a Phase II small molecule sodium channel blocking candidate. In October 2015, the company announced that it would lay off 11% of its workforce, effective immediately. On May 3, 2016, Biogen announced to spin off its hemophilia business, known as Bioverativ . The hemophilia business would become an independent publicly traded company. Bioverativ offered two hemophilia drugs in 2016, Alprolix and Eloctate, and plans on developing its Hemophilia-focused goals. In 2016, Biogen released Spinraza (nusinersin),

2482-510: The discovery and development of treatments for patients with high unmet medical needs in the areas of neurology, hematology, and immunology. Investigational MS medicines: Biogen has several candidates in Phase 1 and 2 clinical trials in neurodegenerative and immunological diseases including MS, neuropathic pain, spinal muscular atrophy and lupus nephritis: Biogen also has several development agreements in place with Ionis Pharmaceuticals to collaborate to leverage antisense technology in advancing

2555-479: The end of its independent existence, G.I. created a program to share "a library of several thousand genes and their related proteins that could be scanned for potential new drugs." This program was based on a G.I. technology that allowed it to identify proteins secreted by cells and therefore more likely to be therapeutic in the body. Wyeth (American Home Products at the time) acquired a majority interest in GI in 1992 and

2628-487: The expiration of options on December 21. The Nasdaq-100 is frequently confused with the Nasdaq Composite Index. The latter index (often referred to simply as "The Nasdaq" ) includes the stock of every company that is listed on Nasdaq (more than 3,000 altogether). The Nasdaq-100 is a modified capitalization-weighted index . This particular methodology was created in 1998 in advance of the creation of

2701-502: The index (usually the one with the larger market capitalization). While the composition of the Nasdaq-100 changes in the case of delisting (such as transferring to another exchange, mergers and acquisitions , or declaring bankruptcy , and in a few cases, being delisted by Nasdaq for failing to meet listing requirements), the index is rebalanced once a year, in December, when Nasdaq reviews its components, compares them with those not in

2774-482: The index following its failed acquisition by Qualcomm , replacing CA, which merged with Broadcom. On November 19, Xcel Energy replaced Dentsply Sirona. On December 14, Nasdaq announced that 6 stocks will join the index on December 24: Advanced Micro Devices , lululemon Athletica , NetApp , United Continental Holdings , Verisign and Willis Towers Watson , replacing Express Scripts, Hologic, Qurate Retail Group, Seagate Technology, Shire and Vodafone. On March 19,

2847-421: The index on December 21 due to annual re-ranking: Ctrip , Endo International , Expedia Group , Maxim Integrated Products , Norwegian Cruise Line , T-Mobile US and Ulta Beauty , replacing C. H. Robinson Worldwide , Expeditors International , Garmin , Keurig Green Mountain , Staples , VimpelCom and Wynn Resorts . Two Liberty Media (Liberty Global plc) tracking stocks (LILA) and (LILAK) were removed from

2920-976: The index over time for various reasons. DirecTV replaced BEA Systems on April 30, 2008 CA Technologies replaced Tellabs on May 19, 2008. FLIR Systems replaced UAL Corporation on July 21, 2008, and on November 10, 2008 Seagate Technology replaced Monster Worldwide . On December 22, 2008, Nasdaq added the following companies to the Nasdaq-100 index: Automatic Data Processing , First Solar , Life Technologies , Ross Stores , Maxim Integrated Products , Illumina , Pharmaceutical Product Development , O'Reilly Auto Parts , Urban Outfitters , J. B. Hunt and Warner Chilcott , replacing Amylin Pharmaceuticals , Cadence Design Systems , Discovery Communications , Lamar Advertising Company , Leap Wireless International , Level 3 Communications , PetSmart , SanDisk , Sirius XM Radio , Virgin Media and Whole Foods Market . On January 20, 2009, News Corporation

2993-505: The index was initially set at 250, but when it closed near 800 on December 31, 1993, the base was reset at 125 the following trading day, leaving the halved Nasdaq-100 price below that of the more commonly known Nasdaq Composite . The first annual adjustments were made in 1993 in advance of options on the index that would trade at the Chicago Board Options Exchange in 1994. Foreign companies were first admitted to

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3066-544: The index's seven companies incorporated in foreign countries are as follows: Additionally, the Nasdaq-100 is also the only index of the three that has a regularly scheduled re-ranking of its index each year (in December), ensuring that the largest non-financial companies on Nasdaq are accurately included. In 2006, Nasdaq created a "farm team" index, the Nasdaq Q-50, representing the next fifty stocks in line to enter

3139-859: The index, and Zoom Video Communications replaced Willis Towers Watson on April 30. On June 22, DocuSign replaced United Airlines Holdings , and other replacements that year included Moderna replacing CoStar Group on July 20, Pinduoduo replacing NetApp on August 24, and Keurig Dr Pepper replacing Western Digital on October 19. On December 21, six companies joined the index: American Electric Power , Atlassian , Marvell Technology Group , Match Group , Okta and Peloton Interactive . They replaced BioMarin Pharmaceutical , Citrix Systems , Expedia Group , Liberty Global (both classes of shares), Take-Two Interactive and Ulta Beauty . On July 21, Honeywell replaced Alexion Pharmaceuticals , following its acquisition by AstraZeneca . On August 26, Crowdstrike replaced Maxim Integrated Products , which

3212-540: The index, effective December 22, replacing Expedia Group , F5 Networks and Maxim Integrated Products . On March 23, Walgreens Boots Alliance replaced Equinix in the index. Although it was still listed on NASDAQ, Equinix converted into a real estate investment trust , making it ineligible for inclusion in the Nasdaq-100, but it did gain eligibility for the Nasdaq Financial-100. On July 1, Liberty Interactive created two new tracking stocks, tracking

3285-514: The index, leaving 106 separate components. On February 1, Avago Technologies changed its name to Broadcom . On February 22, CSX Corporation replaced KLA-Tencor as a member of the index. On March 16, NetEase replaced SanDisk as a member of the index. On April 18, Liberty Media established two tracking stocks (BATRA), (BATRK) to follow the performance of its investment in the Atlanta Braves . On June 20, Dentsply Sirona returned to

3358-438: The index, re-ranks all eligible companies and makes the appropriate adjustments. There are two tools the Nasdaq uses to determine the market values of companies for the annual review: Those components that are in the top 100 of all eligible companies at the annual review are retained in the index. Those ranked 101 to 125 are retained only if they were in the top 100 of the previous year's annual review. If they fail to move into

3431-554: The index, replacing Life Technologies . On October 29, VimpelCom replaced Dell . On November 18, Marriott International was added to the index, replacing Randgold Resources . On December 23, 2013, 10 changes to the index took place. The five companies joining the index were DISH Network Corporation , Illumina , NXP Semiconductors , Tractor Supply Company and TripAdvisor . The five companies that were dropped were Fossil Group , Microchip Technology , Nuance Communications , Sears Holdings and Dentsply . On April 3, 2014,

3504-553: The index, replacing Joy Global, which transferred its listing to the NYSE. Perrigo had been a member of the index in the 1990s, being dropped in 1996. On December 19, 2011, five companies joined the Nasdaq-100 index due to the annual reranking of the index: Avago Technologies , Fossil Group , Monster Beverage , Nuance Communications and Randgold Resources , replacing FLIR Systems , Illumina , NII Holdings , Qiagen and Urban Outfitters . On April 23, 2012, Texas Instruments replaced First Solar . On May 30, 2012, Viacom became

3577-517: The index, replacing four Liberty Media tracking stocks (LMCA), (LMCK), (BATRA), (BATRK). On July 18, Microchip Technology returned to the index, replacing Endo International. On October 19, Shire PLC replaced Linear Technology in the index. On December 9, the annual re-ranking of the index was announced, resulting in four changes. Joining the index December 19 were Cintas , Hasbro , Hologic and KLA-Tencor . Bed Bath & Beyond , NetApp , Stericycle and Whole Foods Market were dropped from

3650-474: The index. On February 1, Tesla Motors changed its corporate name to simply Tesla. On February 7, J. B. Hunt replaced NXP Semiconductors in the index. On March 20, Idexx Laboratories replaced SBA Communications in the index after SBA converted to a REIT, rendering it ineligible for inclusion. On April 24, Wynn Resorts replaced TripAdvisor . On June 19, MercadoLibre replaced Yahoo! Inc due to its acquisition by Verizon and subsequent conversion to

3723-412: The index. Anticipation of these changes can lead to changes in the stock prices of affected companies. The index publicly announces all changes, regardless of when they occur, via press releases at least five business days before the change takes place. The 2018 results of the re-ranking and rebalancing were announced on December 14, with the changes effective the morning of December 24, coinciding with

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3796-421: The index. Of these, only four, Apple, Costco (through its merger in 1993 with Price Club , with Costco, as a separate entity, not becoming a component until at least 1989), Intel and PACCAR, have been components, continuously, since the first dissemination of the index in 1985. Two other current components, KLA Corporation and Micron Technology, were also components when the index started, but have been removed from

3869-468: The largest non-financial companies listed on the Nasdaq stock exchange. It is a modified capitalization-weighted index . The stocks' weights in the index are based on their market capitalizations , with certain rules capping the influence of the largest components. It is limited to companies from a single exchange, and it does not have any financial companies. The financial companies are in a separate index,

3942-602: The market open: Vodafone , Mattel , BMC Software , Mylan , Qiagen , SanDisk and Virgin Media . These stocks replaced Akamai Technologies , Hansen Natural , IAC/InterActiveCorp , Liberty Global , Pharmaceutical Product Development , Ryanair and Steel Dynamics . On December 20, 2010, seven companies were added to the Nasdaq-100 index: F5 Networks , Akamai Technologies , Netflix , Micron Technology , Whole Foods Market , Ctrip and Dollar Tree , replacing Cintas , Dish Network , Foster Wheeler , Hologic , J. B. Hunt , Logitech and Patterson Companies . These were

4015-454: The name Biogen Idec. After the merger, Biogen Idec became the 3rd largest Biotechnology company in the world. Following shifts in research core areas, the company has since shortened its name, reverting to simply Biogen. Biogen stock is a component of several stock indices such as the S&;P 500 , S&P 1500 , and NASDAQ-100 and the company is listed on the NASDAQ stock exchange under

4088-502: The news that Biogen was planning to pay Elan $ 3.25 billion for the full rights to Tysabri , used to treat multiple sclerosis. In 2013, Biogen was the first U.S.-based biotechnology company to appear on the Dow Jones Sustainability World Index . In January 2015, the company announced that it would acquire Convergence Pharmaceuticals for up to $ 675 million, with the acquisition aiming to accelerate

4161-420: The only changes made to the index that year and the fewest since 1997. On April 4, 2011, Alexion Pharmaceuticals replaced Genzyme before the market open. On May 27, 2011, Green Mountain Coffee Roasters replaced Millicom International Cellular after Millicom (MICC) withdrew its Nasdaq listing. On July 15, 2011, Sirius XM Radio replaced Cephalon in the index, and on December 6, 2011, Perrigo joined

4234-675: The potential to reduce Aβ plaques that form in the brains of patients, as well as to slow the formation of new plaques, potentially improving symptoms and suppressing disease progression. Biogen also has since 2015 an agreement with AGTC to develop gene therapy for several genetic diseases, including X-linked retinoschisis (XLRS) and X-linked Retinitis pigmentosa (XLRP) ophthalmologic diseases. To this aim, Biogen paid AGTC $ 124 million, including an equity investment of $ 30 million, and up to 1,1 billion in future milestones. In March 2019, Biogen halted Phase 3 trials of Alzheimer's disease drug Aducanumab after "an independent group's analysis show[ed] that

4307-488: The previous fiscal cycle. Biogen's shares traded at over $ 289 per share, and its market capitalization was valued at over US$ 63 billion in November 2018. The company ranked 228 on the 2021 Fortune 500 list of the largest United States corporations by revenue. Biogen and Japanese Eisai are collaborators in the development and commercialization of ADUHELM. Biogen and Swedish Orphan Biovitrum (Sobi) are collaborators in

4380-653: The remaining interest at the end of 1996. The company became part of Wyeth's Research division. Biogen Biogen Inc. is an American multinational biotechnology company based in Cambridge, Massachusetts , United States specializing in the discovery, development, and delivery of therapies for the treatment of neurological diseases to patients worldwide. Biogen operates in Argentina, Brazil, Canada, China, France, Germany, Hungary, India, Italy, Japan, Mexico, Netherlands, Poland, Sweden, and Switzerland. Biogen

4453-399: The ticker symbol, BIIB. In May 2006, the company announced it would acquire cancer specialist, Conforma Therapeutics for $ 250 million. Later in the same month, the company announced its intention to acquire Fumapharm AG, consolidating ownership of Fumaderm and BG-12 , an oral fumarate , which was being studied for the treatment of multiple sclerosis and psoriasis . In January 2007,

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4526-425: The top 100 in the following year's review, they are dropped. Those not ranked in the top 125 are dropped regardless of the previous year's rank. The index also drops a company if, at the end of two consecutive months, it fails to have an index weighting of at least one-tenth of a percent. This can occur at any time. Companies that are dropped are replaced by those with the largest market value that are not already in

4599-567: The traditional QQQ product. QQQ is one of the most actively traded exchange-traded funds in the United States. The Nasdaq-100 is often abbreviated as NDX, NDQ, NAS100 or US100 in the derivatives markets . Its corresponding futures contracts are traded on the Chicago Mercantile Exchange . The regular futures are denoted by the Reuters Instrument Code ND, and the smaller E-mini version uses

4672-548: The treatment of neurological disorders. In February 2012, Biogen formalized a joint venture with Samsung , creating Samsung Bioepis. This joint venture brings Biogen's expertise and capabilities in protein engineering, cell line development, and recombinant biologics manufacturing to position the joint venture so Biogen can participate in the emerging market for biosimilars. In early 2014, Biogen entered into an agreement with Eisai, Inc., to jointly develop and commercialize two of their candidates for Alzheimer's disease, which have

4745-513: The trials were unlikely to 'meet their primary endpoint.'" However, in October 2019 they reversed their plans and said that they would be pursuing US FDA approval for Aducanumab. The reversal came after Biogen said a new analysis of a larger patient pool showed promising results. In July 2020, Biogen completed submission of a Biologics license application (BLA) to the FDA for review, and requested accelerated review. However, an advisory panel for

4818-508: The two classes of stock of Fox Corporation replaced the two classes of stock of 21st Century Fox . On November 21, Exelon replaced Celgene . On December 13, Nasdaq announced that as a result of the annual re-ranking of the index, six companies would join December 23: Ansys , CDW , Copart , CoStar Group , Seattle Genetics and Splunk , replacing Hasbro , Henry Schein , J.B. Hunt , Mylan , NortonLifeLock and Wynn Resorts . On April 20, Dexcom replaced American Airlines Group in

4891-408: Was added to the index, replacing Focus Media Holding , which did not meet the minimum monthly weight requirements. On July 17, 2009, Cerner replaced Sun Microsystems after Sun Microsystems was acquired by Oracle . On October 29, 2009, Priceline.com replaced Juniper Networks after Juniper transferred its listing to the NYSE. On December 21, 2009, seven stocks joined the Nasdaq-100 index before

4964-796: Was added to the index, replacing Infosys , which transferred its listing to the NYSE . On December 24, 2012, 20 changes to the index took place. The ten companies joining the index were Analog Devices , Catamaran Corporation , Discovery Communications , Equinix , Liberty Global , Liberty Media , Regeneron Pharmaceuticals , SBA Communications , Verisk Analytics and Western Digital . The ten companies being dropped were Apollo Group , Electronic Arts , Flextronics , Green Mountain Coffee Roasters , Lam Research , Marvell Technology Group , Netflix , Research in Motion , VeriSign and Warner Chilcott . On January 15, 2013, Starz replaced Liberty Media after

5037-537: Was founded in 1978 in Geneva as Biotechnology Geneva by several prominent biologists, including Kenneth Murray from the University of Edinburgh , Phillip Allen Sharp from the Massachusetts Institute of Technology , Walter Gilbert from Harvard University (Gilbert served as CEO during the start-up phase of Biogen), Heinz Schaller from the University of Heidelberg , and Charles Weissmann from

5110-500: Was moved from the American Stock Exchange , where it had the symbol QQQ, to the Nasdaq , and given the new ticker symbol QQQQ, sometimes called the "quad Qs" by traders. On March 23, 2011, Nasdaq changed its symbol back to QQQ. Retail buy and hold investors might prefer to purchase Invesco's similar Nasdaq: QQQM, or "QQQ Mini" which has a lower fee structure, but lacks the liquidity that high-frequency traders need in

5183-680: Was one of the seminal non-profit research centers in this field locally, among many others. Aside from MIT, Harvard, Boston University and several teaching hospitals including Massachusetts General Hospital and Brigham and Women's were important contributors to the local field's development. G.I.'s Products (or potential candidates for products) included forms of M-CSF , interleukin-3, interleukin-11 (Neumega), bone morphogenetic protein 2,recombinant human Factor IX, and recombinant human Factor VIII (Recombinate); as well as tissue plasminogen activator and erythropoetin that both involved costly, complex lawsuits over patent infringement with competitors. Toward

5256-597: Was preparing to go through a late-stage trial of its experimental Alzheimer's disease treatment after the medication dramatically improved cognition and reduced brain plaque levels in early-stage study. In March 2015, Aducanumab became the first experimental Alzheimer's treatment to show significant results in regard to slowing down cognitive decline and reducing brain-destroying plaques. In July 2015, Biogen initiated two late-stage studies called ENGAGE and EMERGE, which will assess Aducanumab in adults with early Alzheimer's disease. In 2016, Aducanumab decreased amoyloid-beta in

5329-416: Was removed on July 31, after being acquired by Merck KGaA . Skyworks Solutions replaced Sigma-Aldrich on August 3. Altera was removed on October 7 as a result of its merger with Intel. Incyte replaced Altera's on that date. PayPal was added to the index on November 11, as Broadcom was in the process of merging with Avago. Nasdaq announced on December 11 that seven companies would be replaced in

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