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79-475: One of the most widespread types of demand-responsive transport (DRT) is to provide a public transport service in areas of low passenger demand where a regular bus service is not considered to be financially viable, such as rural and peri-urban areas. Services may also be provided for particular types of passengers. One example is the paratransit programs for people with a disability. The provision of public transport in this manner emphasises one of its functions as

158-495: A community interest company in the UK). They may also be provided by private companies for commercial reasons; some conventional bus operating companies have set up DRT-style airport bus services, which compete with larger private hire airport shuttle companies. DRT can potentially reduce the number of vehicles on the road, and hence pollution and congestion, if many people are persuaded to use it instead of private cars or taxis. For

237-625: A healthy diet are also recommended. Supportive care in severe cases includes treatment to relieve symptoms , fluid therapy , oxygen support and prone positioning , and medications or devices to support other affected vital organs. More severe cases may need treatment in hospital. In those with low oxygen levels, use of the glucocorticoid dexamethasone is recommended to reduce mortality. Noninvasive ventilation and, ultimately, admission to an intensive care unit for mechanical ventilation may be required to support breathing. Extracorporeal membrane oxygenation (ECMO) has been used to address

316-627: A variant of concern (VoC) or a variant of interest (VoI). Many of these variants have shared the more infectious D614G . As of May 2023, the WHO had downgraded all variants of concern to previously circulating as these were no longer detected in new infections. Sub-lineages of the Omicron variant (BA.1 – BA.5) were considered separate VoCs by the WHO until they were downgraded in March 2023 as no longer widely circulating. As of 24 September 2024 ,

395-456: A broad operational range would require no public subsidies". DRT schemes may require new or amended legislation, or special dispensation, to operate, as they do not meet the traditional licensing model of authorised bus transport providers or licensed taxicab operators. The status has caused controversy between bus and taxi operators when the DRT service picks up passengers without pre-booking, due to

474-511: A collaboration between the PTAs in a joint venture, FlexDanmark , thus providing nationwide DRT-services (excluding some islands). There are three major operational areas: There is paratransit service ( palvelulinja, palveluliikenne ) in many cities and municipalities in Finland. It is mainly aimed at those who find it difficult to use other public transport, but often anyone who wants to can order

553-493: A comprehensive international study. Such deaths include deaths due to healthcare capacity constraints and priorities, as well as reluctance to seek care (to avoid possible infection). Further research may help distinguish the proportions directly caused by COVID-19 from those caused by indirect consequences of the pandemic. In May 2022, the WHO estimated the number of excess deaths by the end of 2021 to be 14.9 million compared to 5.4 million reported COVID-19 deaths, with

632-475: A day. Uses 60 vehicles and 10–20 more for school transport for children with special needs. A network of over 1,000 demand responsive transport routes are provided across rural Ireland under the TFI Local Link brand. Many of these routes are once a week services which operate a door-to-door pickup from a rural area into a nearby large town, where people can access shopping and other services, followed by

711-428: A door-to-door service as practical by using narrower residential streets. In some cases taxicabs are hired by the DRT provider to serve their routes on request. DRT schemes may be fully or partially funded by the local transit authority , with operators selected by public tendering or other methods. Other schemes may be partially or fully self-funded as community centred not for profit social enterprises (such as

790-595: A large number of people". During the COVID-19 pandemic, as with other pandemics, the meaning of this term has been challenged. The end of a pandemic or other epidemic only rarely involves the total disappearance of a disease, and historically, much less attention has been given to defining the ends of epidemics than their beginnings. The ends of particular epidemics have been defined in a variety of ways, differing according to academic field, and differently based on location and social group. An epidemic's end can be considered

869-451: A median range of 0.24% to 1.49%. IFRs rise as a function of age (from 0.002% at age 10 and 0.01% at age 25, to 0.4% at age 55, 1.4% at age 65, 4.6% at age 75, and 15% at age 85). These rates vary by a factor of ≈10,000 across the age groups. For comparison, the IFR for middle-aged adults is two orders of magnitude higher than the annualised risk of a fatal automobile accident and much higher than

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948-475: A model of a hypothetical large-scale demand-responsive public transport system for the Helsinki metropolitan area, simulation results published in 2005 demonstrated that "in an urban area with one million inhabitants, trip aggregation could reduce the health, environmental, and other detrimental impacts of car traffic typically by 50–70%, and if implemented could attract about half of the car passengers, and within

1027-521: A prototype service, GAD-About, which offered pre-booked door-to-door transport for its members, inspired by similar minibus usage in church and youth clubs. That was then cloned as an easily scalable module, under the aegis of London Transport, to become the Dial-a-Ride service launched as part the general services of Transport for London (TfL), rather than as a bus service. Examples of UK schemes include: The large majority of 1,500 rural systems in

1106-466: A published schedule. Regulations concerning bus service registration and application of bus-operating grants for England and Wales were amended in 2004 to allow registration of fully flexible pre-booked DRT services. Some services, such as LinkUp, only pick up passengers at 'meeting points', but can set down at the passenger's destination. The Greenwich Association of the Disabled had earlier developed

1185-489: A quantitative (e.g. new residential zones) sense. It is frequently seen as a result of post-modernity . In science, the term was used initially in France and Switzerland . Peri-urban areas (also called urban space , outskirts or the hinterland ) are defined by the structure resulting from the process of peri-urbanisation. It can be described as the landscape interface or ecotone between town and countryside, or also as

1264-824: A random sample have consistently found that total infections considerably exceed the reported case counts. Many countries, early on, had official policies to not test those with only mild symptoms. The strongest risk factors for severe illness are obesity, complications of diabetes , anxiety disorders, and the total number of conditions. During the start of the COVID-19 pandemic it was not clear whether young people were less likely to be infected, or less likely to develop symptoms and be tested. A retrospective cohort study in China found that children and adults were just as likely to be infected. Among more thorough studies, preliminary results from 9 April 2020 found that in Gangelt ,

1343-485: A return service a few hours later with a door-to-door drop off back to the same rural area. Other routes include daily return services to/from colleges or employment centres, weekend evening services to/from a night-time activity centre, weekly services to attend Mass, feeder services to connect with scheduled bus and train services, and services on off-shore islands to connect with ferry departures and arrivals. Services are managed by 15 regional TFI Local Link offices across

1422-417: A service that can deviate from a fixed route. These operate along a fixed alignment or path at specific times but may deviate to collect or drop off passengers who have requested the deviation. DRT services are restricted to a defined operating zone, within which journeys must start and finish. Journeys may be completely free form, or following skeleton routes and schedules, varied as required, with users given

1501-461: A social phenomenon, not just a biological one. Time reported in March 2024 that expert opinions differ on whether or not COVID-19 is considered endemic or pandemic, and that the WHO continued to call the disease a pandemic on its website. During the initial outbreak in Wuhan , the virus and disease were commonly referred to as "coronavirus", "Wuhan coronavirus", "the coronavirus outbreak" and

1580-425: A social service rather than creating a viable movement network. DRT can be used to refer to many different types of transport. When taxicabs were first introduced to many cities, they were hailed as an innovative form of DRT. They are still referred to as DRT in some jurisdictions around the world as their very nature is to take people from point-to-point based on their needs. More recently, DRT generally refers to

1659-445: A specified pick-up point and a time window for collection. Some DRT systems may have defined termini , at one or both ends of a route, such as an urban centre, airport or transport interchange , for onward connections. DRT systems require passengers to request a journey in advance. They may do this by booking with a central dispatcher who determines the journey options available given the user's location and destination. Increasingly,

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1738-451: A test. Conversely, deaths of people who died from underlying conditions following a positive test may be included. Countries such as Belgium include deaths from suspected cases, including those without a test, thereby increasing counts. Official death counts have been claimed to underreport the actual death toll, because excess mortality (the number of deaths in a period compared to a long-term average) data show an increase in deaths that

1817-561: A trip. Red minibuses which serve non-franchised routes across the country, depending on routes, allow passengers to reserve their seats by phone such that operators and drivers are able to know where passengers are and how many there are in deploying their vehicles. Public transport authority in the Icelandic capital of Reykjavik and the surrounding municipalities. Manages public bus transport and disabled transport, but does not have its own vehicles. About 1,300 enquiries and thousand trips

1896-614: A type of public transport. They are distinct from fixed-route services as they do not always operate to a specific timetable or route. While specific operations vary widely, generally a particular area is designated for service by DRT. Once a certain number of people have requested a trip, the most efficient route will then be calculated depending on the origins and destinations of passengers. Share taxis are another form of DRT. They are usually operated on an ad hoc basis but also do not have fixed routes or times and change their route and frequency depending on demand. Some DRT systems operate as

1975-468: Is an example of DRT used for people with special needs (paratransit). DRT services have operated in some sparsely populated areas (under 100 p/km) since 1995. PostBus Switzerland Ltd , the national post company, has operated a DRT service called PubliCar , formerly also Casa Car . Some DRT schemes were operating under the UK bus-operating regulations of 1986, allowed by having core start and finish points and

2054-518: Is associated with COVID-19 and is reported in as many as 88% of cases. The disease is mainly transmitted via the respiratory route when people inhale droplets and small airborne particles (that form an aerosol ) that infected people exhale as they breathe, talk, cough, sneeze, or sing. Infected people are more likely to transmit COVID-19 when they are physically close to other non-infected individuals. However, infection can occur over longer distances, particularly indoors. SARS‑CoV‑2 belongs to

2133-611: Is discouraged altogether by the World Health Organization (WHO), due to limited evidence of its efficacy. The severity of COVID-19 varies. It may take a mild course with few or no symptoms, resembling other common upper respiratory diseases such as the common cold . In 3–4% of cases (7.4% for those over age 65) symptoms are severe enough to cause hospitalisation. Mild cases typically recover within two weeks, while those with severe or critical diseases may take three to six weeks to recover. Among those who have died,

2212-439: Is intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes coronavirus disease 2019 ( COVID-19 ). Prior to the COVID-19 pandemic, an established body of knowledge existed about the structure and function of coronaviruses causing diseases like severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). This knowledge accelerated

2291-490: Is not explained by COVID-19 deaths alone. Using such data, estimates of the true number of deaths from COVID-19 worldwide have included a range from 18.2 to 33.5 million (≈27.4 million) by 18 November 2023 by The Economist , as well as over 18.5 million by 1 April 2023 by the Institute for Health Metrics and Evaluation and ≈18.2 million (earlier) deaths between 1 January 2020, and 31 December 2021, by

2370-485: Is public transport, but with smaller vehicles that run on demand. Plustur is flexible transport that can be used in cases where the bus or train does not run all the way. Flexrute is public transport on demand - without a fixed timetable, which drives from stop to stop within a defined geographical area. There are also special needs school transport and paratransit services. The DRT-services in Denmark are maintained as

2449-452: Is the ratio of deaths to diagnoses. This metric can be misleading because of the delay between symptom onset and death and because testing focuses on symptomatic individuals. Based on Johns Hopkins University statistics, the global CFR was 1.02 percent (6,881,955 deaths for 676,609,955 cases) as of 10 March 2023. The number varies by region and has generally declined over time. Several variants have been named by WHO and labelled as

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2528-406: Is the seventh known coronavirus to infect people, after 229E , NL63 , OC43 , HKU1 , MERS-CoV , and the original SARS-CoV . The standard method of testing for presence of SARS-CoV-2 is a nucleic acid test , which detects the presence of viral RNA fragments. As these tests detect RNA but not infectious virus, its "ability to determine duration of infectivity of patients is limited." The test

2607-614: Is typically done on respiratory samples obtained by a nasopharyngeal swab ; however, a nasal swab or sputum sample may also be used. The WHO has published several testing protocols for the disease. Preventive measures to reduce the chances of infection include getting vaccinated, staying at home or spending more time outdoors, avoiding crowded places, keeping distance from others, wearing a mask in public, ventilating indoor spaces, managing potential exposure durations, washing hands with soap and water often and for at least twenty seconds, practising good respiratory hygiene, and avoiding touching

2686-514: The Huanan Seafood Wholesale Market there, but it is possible that human-to-human transmission began earlier. Molecular clock analysis suggests that the first cases were likely to have been between October and November 2019. The scientific consensus is that the virus is most likely of a zoonotic origin, from bats or another closely related mammal. While other explanations such as speculations that SARS-CoV-2

2765-407: The Institute for Health Metrics and Evaluation estimating the true number of cases as of early 2022 to be in the billions. One measure that public health officials and policymakers have used to monitor the pandemic and guide decision-making is the test positivity rate ("percent positive"). According to Johns Hopkins in 2020, one benchmark for a "too high" per cent positive is 5%, which was used by

2844-602: The basic reproduction number (R 0 ) for COVID-19 in January 2020 were between 1.4 and 2.5, but a subsequent analysis claimed that it may be about 5.7 (with a 95 per cent confidence interval of 3.8 to 8.9). In December 2021, the number of cases continued to climb due to several factors, including new COVID-19 variants. As of that 28   December, 282,790,822 individuals worldwide had been confirmed as infected. As of 14 April 2022 , over 500 million cases were confirmed globally. Most cases are unconfirmed, with

2923-610: The rural–urban fringe , the outskirts or the urban hinterland . The expression originates from the French word périurbanisation ("peri-urban" meaning "around urban"), which is used by the INSEE (the French statistics agency) to describe spaces—between the city and the countryside—that are shaped by the fragmented urbanisation of former rural areas in the urban fringe, both in a qualitative (e.g. diffusion of urban lifestyle) and in

3002-474: The variants of interest as specified by the World Health Organization are BA.2.86 and JN.1, and the variants under monitoring are JN.1.7, KP.2, KP.3, KP.3.1.1, JN.1.18, LB.1, and XEC. Symptoms of COVID-19 are variable, ranging from mild symptoms to severe illness. Common symptoms include headache, loss of smell and taste , nasal congestion and runny nose , cough, muscle pain , sore throat , fever, diarrhoea , and breathing difficulties . People with

3081-429: The "Wuhan coronavirus outbreak", with the disease sometimes called "Wuhan pneumonia ". In January 2020, the WHO recommended 2019-nCoV and 2019-nCoV acute respiratory disease as interim names for the virus and disease per 2015 international guidelines against using geographical locations (e.g. Wuhan, China), animal species, or groups of people in disease and virus names in part to prevent social stigma . WHO finalised

3160-734: The 1,700 local governments in Japan have introduced DRT public transport services. The first ever demand-responsive transport scheme in Poland – called Tele-Bus – has been operated since 2007 in Kraków by MPK, the local public transport company (see also Tramways in Kraków ). Regional transport authority in Västra Götaland in southwestern Sweden is responsible for all public transport and for transport offers to citizens with special needs. This

3239-611: The 1980s, a second wave of systems were launched from the mid-1990s. There are now DRT schemes in urban and peri-urban areas as well as in rural communities. Operated by both public transport companies and private service providers, the DRT schemes are offered either as intermediate collective transport services for generic users or as schemes for specific user groups. DRT schemes operate in major cities including Rome , Milan , Genoa , Florence , and in several mid- to small-size towns including Alessandria, Aosta, Cremona, Livorno, Mantova, Parma, Empoli , Siena , and Sarzana. More than 200 of

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3318-511: The US provide demand-response service; there are also about 400 urban DRT systems. As of 2022, at least 30 transit agencies in Florida have demand-response trips. Peri-urbanisation Peri-urbanisation relates to the processes of scattered and dispersive urban growth that create hybrid landscapes of fragmented and mixed urban and rural characteristics. Such areas may be referred to as

3397-640: The WHO in the past. As of 10 March 2023, more than 6.88   million deaths had been attributed to COVID-19. The first confirmed death was in Wuhan on 9 January 2020. These numbers vary by region and over time, influenced by testing volume, healthcare system quality, treatment options, government response, time since the initial outbreak, and population characteristics, such as age, sex, and overall health. Multiple measures are used to quantify mortality. Official death counts typically include people who died after testing positive. Such counts exclude deaths without

3476-419: The WHO, US, European Union, and Australia. On 12 November 2022, the WHO released its Global Vaccine Market Report. The report indicated that "inequitable distribution is not unique to COVID-19 vaccines"; countries that are not economically strong struggle to obtain vaccines. On 14 November 2022, the first inhalable vaccine was introduced, developed by Chinese biopharmaceutical company CanSino Biologics , in

3555-523: The booking is via an app, which provides the interface to software that creates a schedule in real time; adjusting the schedule to accept (or reject) bookings as they come in. This provides an instant decision for the potential user, but at the cost of efficiency: each individual travel need is considered individually, potentially resulting in higher levels of idle time (when the schedule has gaps that are too short to allow an additional journey to be added) and "dead mileage" (driving empty between one drop-off and

3634-477: The boundary of the urbanized area. Covid pandemic The COVID-19 pandemic (also known as the coronavirus pandemic and COVID pandemic ), caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ), began with an outbreak of COVID-19 in Wuhan , China, in December 2019. It spread to other areas of Asia, and then worldwide in early 2020. The World Health Organization (WHO) declared

3713-448: The broad family of viruses known as coronaviruses . It is a positive-sense single-stranded RNA (+ssRNA) virus, with a single linear RNA segment. Coronaviruses infect humans, other mammals, including livestock and companion animals, and avian species. Human coronaviruses are capable of causing illnesses ranging from the common cold to more severe diseases such as Middle East respiratory syndrome (MERS, fatality rate ≈34%). SARS-CoV-2

3792-648: The centre of a major infection cluster in Germany, 15 per cent of a population sample tested positive for antibodies . Screening for COVID-19 in pregnant women in New York City , and blood donors in the Netherlands, found rates of positive antibody tests that indicated more infections than reported. Seroprevalence -based estimates are conservative as some studies show that persons with mild symptoms do not have detectable antibodies. Initial estimates of

3871-760: The city of Shanghai, China. For the first two years of the pandemic, no specific and effective treatment or cure was available. In 2021, the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) approved the oral antiviral protease inhibitor , Paxlovid (nirmatrelvir plus the HIV antiviral ritonavir ), to treat adult patients. FDA later gave it an EUA. Most cases of COVID-19 are mild. In these, supportive care includes medication such as paracetamol or NSAIDs to relieve symptoms (fever, body aches, cough), adequate intake of oral fluids and rest. Good personal hygiene and

3950-824: The country on behalf of the National Transport Authority (NTA) , and usually require prebooking by phoning the relevant office in advance. As of June 2023, there are no real-time app-based demand responsive transport services operating in Ireland, but in April 2023 the NTA informed suppliers that they intended "to procure a trial of and, if successful a roll out of, Smart Demand Responsive Transport services (SDRT), using app based products to secure services and routing algorithms to match vehicles with capacity to users". Following some pioneering DRT schemes implemented in

4029-484: The cumulative number of infected individuals (including asymptomatic and undiagnosed infections and excluding vaccinated infected individuals). It is expressed in percentage points. Other studies refer to this metric as the infection fatality risk . In November 2020, a review article in Nature reported estimates of population-weighted IFRs for various countries, excluding deaths in elderly care facilities, and found

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4108-448: The density may be as low as 500 per square mile. Urban areas also include outlying territory of less density if it is connected to the core of the contiguous area by road and within 2.5 road miles of that core, or within 5 road miles but separated by water or other undevelopable territory. Territory with population density below 1,000 people per square mile is included in the urban fringe if it eliminates an enclave or closes an indentation in

4187-441: The development of various vaccine platforms during early 2020. The initial focus of SARS-CoV-2 vaccines was on preventing symptomatic and severe illness. The COVID-19 vaccines are widely credited for their role in reducing the severity and death caused by COVID-19. As of March 2023, more than 5.5 billion people had received one or more doses (11.8 billion in total) in over 197 countries. The Oxford-AstraZeneca vaccine

4266-513: The eyes, nose, or mouth with unwashed hands. Those diagnosed with COVID-19 or who believe they may be infected are advised by healthcare authorities to stay home except to get medical care, call ahead before visiting a healthcare provider, wear a face mask before entering the healthcare provider's office and when in any room or vehicle with another person, cover coughs and sneezes with a tissue, regularly wash hands with soap and water and avoid sharing personal household items. A COVID-19 vaccine

4345-474: The general public beginning in December 2020, made available through government and international programs such as COVAX , aiming to provide vaccine equity . Treatments include novel antiviral drugs and symptom control. Common mitigation measures during the public health emergency included travel restrictions , lockdowns , business restrictions and closures, workplace hazard controls , mask mandates , quarantines, testing systems, and contact tracing of

4424-665: The infected. The pandemic caused severe social and economic disruption around the world, including the largest global recession since the Great Depression . Widespread supply shortages , including food shortages , were caused by supply chain disruptions and panic buying . Reduced human activity led to an unprecedented temporary decrease in pollution . Educational institutions and public areas were partially or fully closed in many jurisdictions, and many events were cancelled or postponed during 2020 and 2021. Telework became much more common for white-collar workers as

4503-439: The issue of respiratory failure. Existing drugs such as hydroxychloroquine , lopinavir/ritonavir , and ivermectin are not recommended by US or European health authorities, as there is no good evidence they have any useful effect. The antiviral remdesivir is available in the US, Canada, Australia, and several other countries, with varying restrictions; however, it is not recommended for use with mechanical ventilation, and

4582-482: The licensing issues. Issues may also arise surrounding tax and fuel subsidy for DRT services. Ridership on DRT services is usually quite low (less than ten passengers per hour), but DRT can provide coverage effectively. Analysis of the Yorbus DRT scheme in a rural area of the UK showed very little combination of individual travel needs. Of the 35% of operating hours when the vehicles were carrying passengers, there

4661-576: The majority of the unreported 9.5 million deaths believed to be direct deaths due the virus, rather than indirect deaths. Some deaths were because people with other conditions could not access medical services . A December 2022 WHO study estimated excess deaths from the pandemic during 2020 and 2021, again concluding ≈14.8 million excess early deaths occurred, reaffirming and detailing their prior calculations from May as well as updating them, addressing criticisms. These numbers do not include measures like years of potential life lost and may make

4740-408: The next pickup) than might be expected from a schedule built by an experienced human operator. DRT systems take advantage of fleet telematics technology in the form of vehicle location systems, scheduling and dispatching software and hand-held/in vehicle computing. Vehicles used for DRT services are typically small minibuses sufficient for low ridership, which allow the service to provide as near

4819-495: The official names COVID-19 and SARS-CoV-2 on 11 February 2020. Tedros Adhanom Ghebreyesus explained: CO   for corona , VI   for virus , D   for disease and 19 for when the outbreak was first identified (31 December 2019). WHO additionally uses "the COVID-19 virus" and "the virus responsible for COVID-19" in public communications. WHO named variants of concern and variants of interest using Greek letters . The initial practice of naming them according to where

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4898-534: The outbreak a public health emergency of international concern (PHEIC) on 30 January 2020, and assessed the outbreak as having become a pandemic on 11 March. COVID-19 symptoms range from asymptomatic to deadly, but most commonly include fever, sore throat , nocturnal cough , and fatigue. Transmission of the virus is often through airborne particles . Mutations have produced many strains (variants) with varying degrees of infectivity and virulence . COVID-19 vaccines were developed rapidly and deployed to

4977-407: The pandemic 2021's leading cause of death . The time between symptom onset and death ranges from   6 to 41 days, typically about 14 days. Mortality rates increase as a function of age. People at the greatest mortality risk are the elderly and those with underlying conditions. The infection fatality ratio (IFR) is the cumulative number of deaths attributed to the disease divided by

5056-495: The pandemic evolved. Misinformation circulated through social media and mass media , and political tensions intensified . The pandemic raised issues of racial and geographic discrimination , health equity , and the balance between public health imperatives and individual rights . The WHO ended the PHEIC for COVID-19 on 5 May 2023. The disease has continued to circulate, but as of 2024, experts were uncertain as to whether it

5135-478: The population's age structure and the age-specific pattern of infections. There have also been reviews that have compared the fatality rate of this pandemic with prior pandemics, such as MERS-CoV. For comparison the infection mortality rate of seasonal flu in the United States is 0.1%, which is 13 times lower than COVID-19. Another metric in assessing death rate is the case fatality ratio (CFR), which

5214-462: The risk of dying from seasonal influenza . In December 2020, a systematic review and meta-analysis estimated that population-weighted IFR was 0.5% to 1% in some countries (France, Netherlands, New Zealand, and Portugal), 1% to 2% in other countries (Australia, England, Lithuania, and Spain), and about 2.5% in Italy. This study reported that most of the differences reflected corresponding differences in

5293-458: The rural—urban transition zone where urban and rural uses and functions mix and often clash. It can thus be viewed as a new landscape type in its own right, one forged from an interaction of urban and rural land use . Its definition shifts depending on the global location, but typically in Europe where suburban areas are intensively managed to prevent urban sprawl and protect agricultural land,

5372-496: The same infection may have different symptoms, and their symptoms may change over time. Three common clusters of symptoms have been identified: one respiratory symptom cluster with cough, sputum , shortness of breath, and fever; a musculoskeletal symptom cluster with muscle and joint pain, headache, and fatigue; a cluster of digestive symptoms with abdominal pain, vomiting, and diarrhoea. In people without prior ear, nose, and throat disorders, loss of taste combined with loss of smell

5451-516: The scattered urban facilities. "Peri-urbanisation" is also sometimes used to fill the gap between suburbanisation and exurbanisation , and thus relates moreover to the movement of people in space. In this case, it implies the expansion of functional rural-urban linkages such as by commuting . In the United States urban areas are defined as contiguous territory having a density of at least 1,000 persons per square mile, though in some areas

5530-411: The time from symptom onset to death has ranged from two to eight weeks. Prolonged prothrombin time and elevated C-reactive protein levels on admission to the hospital are associated with severe course of COVID-19 and with a transfer to intensive care units (ICU). Between 5% and 50% of COVID-19 patients experience long COVID , a condition characterised by long-term consequences persisting after

5609-694: The typical convalescence period of the disease. The most commonly reported clinical presentations are fatigue and memory problems, as well as malaise , headaches, shortness of breath , loss of smell, muscle weakness , low fever and cognitive dysfunction . Many countries attempted to slow or stop the spread of COVID-19 by recommending, mandating or prohibiting behaviour changes, while others relied primarily on providing information. Measures ranged from public advisories to stringent lockdowns. Outbreak control strategies are divided into elimination and mitigation. Experts differentiate between elimination strategies (known as " zero-COVID ") that aim to completely stop

5688-472: The urban fringe will be characterised by certain land uses which have either purposely moved from the urban area or require much larger tracts of land. As examples: Despite these urban uses, the fringe remains largely open with the majority of the land for agricultural, woodland or other rural uses. The quality of living of the countryside around urban areas tends to be low with severance between areas of open land and poorly maintained woodlands and hedgerows with

5767-543: The variants were identified (e.g. Delta began as the " Indian variant") is no longer common. A more systematic naming scheme reflects the variant's PANGO lineage (e.g., Omicron 's lineage is B.1.1.529) and is used for other variants. SARS-CoV-2 is a virus closely related to bat coronaviruses , pangolin coronaviruses, and SARS-CoV . The first known outbreak (the 2019–2020 COVID-19 outbreak in mainland China ) started in Wuhan , Hubei, China, in December 2019. Many early cases were linked to people who had visited

5846-541: The world and thinks a tipping point may have been reached in 2022. There were at least 450 schemes around the world, and in 2021 fifty-four new projects started within a three-month period. David Carnero of Europe-wide DRT technology company Padam said that successful DRT requires subsidies, must be delivered at scale, and must be part of an integrated, rather than competitive, transport policy. All 5 major Public Transit Authorities in Denmark provide door-to-door DRT services in different variants and degree. Flextur

5925-443: Was accidentally released from a laboratory have been proposed, as of 2021 these were not supported by evidence. Official "case" counts refer to the number of people who have been tested for COVID-19 and whose test has been confirmed positive according to official protocols whether or not they experienced symptomatic disease. Due to the effect of sampling bias , studies which obtain a more accurate number by extrapolating from

6004-571: Was just one passenger (or a couple travelling together) for 74% of the time, and two passengers (or couples travelling together) for a further 20% of the time. The 15-seat minibuses could have been replaced by small taxis without capacity problems for 97% of the operating hours. Since the mid-2010s several DRT projects started up but failed. In the US several DRT operators appeared and promptly failed, due to either lack of customers or health and safety issues. 2019 trials in London found that "satisfaction

6083-421: Was really high"; users scored the service at 4.8/5 and praised ease of use, safety, cleanliness and accessibility. But low take-up, misunderstandings about who the service was for, and safety concerns about unlit stops—together with problems due to the covid pandemic from 2020—caused the trials to fail. Lukas Foljanty, a shared-mobility enthusiast and market expert, keeps track of the different DRT schemes around

6162-457: Was still a pandemic. Pandemics and their ends are not well-defined, and whether or not one has ended differs according to the definition used. As of 24 November 2024, COVID-19 has caused 7,075,455 confirmed deaths. The COVID-19 pandemic ranks as the fifth- deadliest pandemic or epidemic in history . In epidemiology , a pandemic is defined as "an epidemic occurring over a very wide area, crossing international boundaries, and usually affecting

6241-509: Was the most widely used. According to a June 2022 study, COVID-19 vaccines prevented an additional 14.4 million to 19.8 million deaths in 185 countries and territories from 8 December 2020 to 8 December 2021. On 8 November 2022, the first recombinant protein-based COVID-19 vaccine (Novavax's booster Nuvaxovid ) was authorised for use in adults in the United Kingdom. It has subsequently received endorsement/authorisation from

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