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64-602: EBP may refer to: EBP (gene) , encoding the emopamil binding protein EBP register , a processor register in the IA-32 instruction set, typically used to hold the stack base pointer (the address of the current stack frame) Earth BioGenome Project Education Business Partnership , in the United Kingdom Efficiency Bandwidth Product, one of

128-434: A causal relationship between stunted growth and environmental enteropathy in children. Several studies are also underway to examine the link between this condition and stunted growth. The exact parthenogenesis of environmental enteropathy causing linear growth failure is unclear, but it is hypothesized that chronic inflammatory state and impaired absorption associated with this condition may inhibit bone growth and affect

192-480: A country's GDP up to 3%. Stunting is highly prevalent in low- and middle income countries (LMICs) and has severe consequences including increased risk of infections, mortality and loss of human capital. The global prevalence of stunting decreased from 33% to 23% between 2000 and 2016. Meanwhile, 37% of children in South Asia are stunted, and due to a large population size, the region bears about 40% of

256-460: A decade (1995–2005) in which stunting rates stagnated in the country, Peru designed and implemented a national strategy against child malnutrition called crecer ("grow"), which complemented a social development conditional cash-transfer program called juntos, which included a nutritional component. The strategy was multisectoral in that it involved the health, education, water, sanitation and hygiene, agriculture and housing sectors and stakeholders. It

320-448: A global level has found that the proportion of stunting that could be attributed to five or more episodes of diarrhea before two years of age was 25%. Since diarrhea is closely linked with water, sanitation and hygiene ( WASH ), this is a good indicator for the connection between WASH and stunted growth. To what extent improvements in drinking water safety, toilet use and good handwashing practices contribute to reduce stunting depends on

384-715: A vicious cycle of poverty and malnutrition, whereby malnourished children are not able to maximally contribute to economic development as adults, and poverty increases chances of malnutrition. The Water and Sanitation Program of the World Bank has investigated links between lack of sanitation and stunting in Vietnam and Lao PDR. An example is in Vietnam where the lack of sanitation in rural villages in mountainous regions of Vietnam led to five-year-old children being 3.7 cm shorter than healthy children living in villages with good access to sanitation. This difference in height

448-841: Is a protein that in humans is encoded by the EBP gene , located on the X chromosome . The protein is shown to have a high-affinity reception for anti-ischemic drugs, such as Emopamil , resulting in its discovery and given name. EBP has a mass of 27.3 kDa and resembles the σ 2 -receptor that resides in the endoplasmic reticulum of various tissues as an integral membrane protein . Mutations in EBP cause Conradi–Hünermann syndrome and impairs cholesterol biosynthesis . Unborn males affected with EBP mutations are not expected to be liveborn, (with up to only 5% male births). Individuals, mostly female, that are liveborn with EBP mutations experience stunted growth , limb reduction and back problems. Later in life,

512-476: Is a stub . You can help Misplaced Pages by expanding it . Stunted growth As of 2020 , an estimated 149 million children under 5 years of age are stunted worldwide. More than 85% of the world's stunted children live in Africa and Asia. Once established, stunting and its effects typically become permanent. Stunted children may never regain the height lost as a result of stunting, and most children will never gain

576-471: Is a key contributing factor that prevents the body from successfully fighting the infection and recovering from these diseases. In the follow-up series in 2013, the focus on undernutrition is expanded to the increasing burden of obesity in both high, middle and low income countries. Several countries with high levels of child stunting and undernutrition are starting to display worrisome increasing trends of child obesity concurrently, due to increased wealth and

640-464: Is associated with reductions in schooling, decreased economic productivity and poverty. Stunted children also display higher risk of developing chronic non-communicable conditions such as diabetes and obesity as adults. If a stunted child undergoes substantial weight gain after age 2, there is a higher chance of becoming obese. This is believed to be caused by metabolic changes produced by chronic malnutrition , that can produce metabolic imbalances if

704-586: Is at 18%, and the Middle East at 16.2%. In Asia, the highest rate is observed in South Asia at 34.4%. South-East Asia is at 26.3%. Pacific Islands also display a high rate at 38.2%. Central and South America are respectively at 15.6 and 9.9%. South Asia, given its very high population at over 1 billion and high prevalence rate of stunting, is the region currently hosting the highest absolute number of children with stunting (60 million plus). Looking at absolute numbers of children under 5 affected by stunting, it

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768-421: Is closely linked to poverty reduction and the will and ability of governments to set up solid multisectoral approaches to reduce chronic malnutrition. Low income countries are the only group with more stunted children today than in the year 2000. Conversely, all other countries (high-income, upper-middle income, lower-middle income) have achieved reductions in the numbers of stunted children. This sadly perpetuates

832-409: Is essential. Achieving so by helping women of reproductive age be in good nutritional status at conception is an excellent preventive measure. A focus on the pre-conception period has recently been introduced as a complement to the key phase of the 1000 days of pregnancy and first two years of life. An example of this are attempts to control anemia in women of reproductive age. A well-nourished mother

896-414: Is irreversible and matters a great deal for a child's cognitive development and future productive potential. The Lancet has published two comprehensive series on maternal and child nutrition, in 2008 and 2013. The series review the epidemiology of global malnutrition and analyze the state of the evidence for cost-effective interventions that should be scaled-up to achieve impact and global targets. In

960-564: Is mostly observed among children from poor households and whose parents are uneducated as they are more likely to continue breast-feeding without meeting minimum dietary diversity requirement. Poor maternal nutrition during pregnancy and breastfeeding can lead to stunted growth of their children. Proper nutrition for mothers during the prenatal and postnatal period is important for ensuring healthy birth weight and for healthy childhood growth. Prenatal causes of child stunting are associated with maternal undernutrition . Low maternal BMI predisposes

1024-404: Is now to optimist nutrition during the first 1000 days of a child's life, from pregnancy to the child's second birthday, in order to reduce the prevalence of stunting. The first 1000 days in a child's life are a crucial "window of opportunity" because the brain develops rapidly, laying the foundation for future cognitive and social ability. Furthermore, it is also the time when young children are

1088-409: Is obvious why current efforts and reductions are insufficient. The absolute number of stunted children has increased in Africa from 50.4 to 58.5 million in the time 2000–2015. This is despite the reduction in percentage prevalence of stunting, and is due to the high rates of population growth. The data therefore indicate that the rate of reduction of stunting in Africa has not been able to counterbalance

1152-569: Is recommended for the first six months of life and complementary feeding of nutritious food alongside breastfeeding for children aged six months to 2-years-old. Prolonged exclusive breastfeeding is associated with under-nutrition because breast milk alone is nutritionally insufficient for children over six months old. Breastfeeding in long time with inadequate complementary feeding leads to growth failure due to insufficient nutrients which are essential for childhood development. The relationship between under-nutrition and prolonged duration of breastfeeding

1216-553: Is stunted. Even though the country's economic growth has steadily increased by 4% annually, almost a third of Filipino children have stunted growth. The prevalence of stunting declined during the early 2000s but has remained the same since then, with the 2019 rate (28.8 percent) only marginally lower than that of 2008. Researchers attribute the problem to micro-nutrient deficiencies brought on by poverty, maternal under-education, food insecurity, and poor environmental conditions. To address stunting and other health and food security issues,

1280-609: Is the first step of stunting prevention, decreasing chances of the baby being born of low birth-weight, which is the first risk factor for future malnutrition. Balanced protein–energy supplementation in pregnancy seem to improve birth weight of children, with greater effects in undernourished women. Meanwhile, micronutrient supplements and lipid based nutrient supplements (LNS) (providing both macro-and micronutrients) during pregnancy have shown mixed effects on birth weight and -length. Similarly, studies supplementing LNS to mothers during pregnancy and lactation and their children during

1344-570: The Thiele/Small parameters Estradiol-binding protein Eurasian Boxing Parliament , a boxing organisation Evidence-based policing Evidence-based policy , in public policy Evidence-based practice , in medicine Extra base power, a baseball statistic that was a predecessor of slugging percentage Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with

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1408-499: The average global growth deficit. Finally, the Lancet -series on maternal and child nutrition estimated that the impact of all existing interventions designed to improve nutrition and prevent related diseases in mothers and children, could reduce stunting at 3 years by merely 36%. Hence, factors explaining the shortfall in observed associations between child feeding practices and nutrient intake and linear growth, have increasingly been

1472-515: The 1,000-day period that spans from conception to a child's second birthday, which constitutes a window of opportunity for growth promotion. The recognition of pre-natal factors underlines the inter-generational aspects of growth, and the need for early interventions. The three main causes of stunting in South Asia, and probably in most developing countries, are poor feeding practices, poor maternal nutrition, and poor sanitation. A recent risk assessment analysis for 137 developing countries found that

1536-442: The 2005–2012 period. This is particularly remarkable given the immense challenges India has faced to address malnutrition, and that the country hosts almost half of all stunted children under 5 in the world. This was achieved through integrated community-based programs that were designed by a central advisory body that promoted multisectoral collaboration, provided advice to policy-makers on evidence-based solutions, and advocated for

1600-559: The Philippine Plan of Action for Nutrition (PPAN) was established as an umbrella initiative to meet health and nutrition targets in the country by 2028. Since 2015, there has been a decline in stunting across all age groups, from infants to teenagers, with the most significant improvement observed among 5 to 10-year-olds, dropping from 31.2 percent in 2015 to 19.7 percent in 2021. [REDACTED]  This article incorporates text by Marianne Sandsmark Morseth available under

1664-666: The SUN Movement with strategies that are aligned with international frameworks of action. Brazil displayed a remarkable reduction in the rates of child stunting under age 5, from 37% in 1974, to 7.1% in 2007. This happened in association with impressive social and economic development that reduced the numbers of Brazilians living in extreme poverty (less than $ 1.25 per day) from 25.6% in 1990 to 4.8% in 2008. The successful reduction in child malnutrition in Brazil can be attributed to strong political commitment that led to improvements in

1728-484: The WHO Child Growth Standards median. As an indicator of nutritional status, comparisons of children's measurements with growth reference curves may be used differently for populations of children than for individual children. The fact that an individual child falls below the fifth percentile for height for age on a growth reference curve may reflect normal variation in growth within a population:

1792-1138: The battle against a problem that has been crippling its development for decades. Of these regions, Latin America and the Caribbean are on track to achieve global targets set with global initiatives such as the United Nations Millennium Development Goals and the World Health Assembly targets (see following section on global targets). Sub-regional stunting rates are as follows: In Africa, the highest rates are observed in East Africa (37.5%). All other Sub-Saharan sub-regions also have high rates, with 32.1% in West Africa, 31.2% in Central Africa, and 28.4% in Southern Africa. North Africa

1856-431: The complementary feeding period show heterogeneous results for stunting. After birth, in terms of interventions for the child, early initiation of breastfeeding, together with exclusive breastfeeding for the first 6 months, are pillars of stunting prevention. Introducing proper complementary feeding after 6 months of age together with breastfeeding until age 2 is the next step. In summary, key policy interventions for

1920-667: The corresponding body weight. One notable contribution to stunted growth is lack of sanitation, leading to public defecation, such as in India. Stunted growth in children has the following public health impacts apart from the obvious impact of shorter stature of the person affected: The impact of stunting on child development has been established in multiple studies. If a child is stunted at age 2 they will have higher risk of poor cognitive and educational achievement in life, with subsequent socio-economic and inter-generational consequences. Multi-country studies have also suggested that stunting

1984-441: The country level have been instrumental in reducing stunting rates, while income growth and governance have played facilitating roles. Inadequate complementary child feeding and a general lack of vital nutrients beside pure caloric intake is one cause for stunted growth. Children need to be fed diets which meet the minimum requirements in terms of frequency and diversity in order to prevent under-nutrition. Exclusive breastfeeding

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2048-571: The current reduction rate, the predicted number in 2025 will be 127 million, indicating the need to scale-up and intensify efforts if the global community is to reach its goals. The World Bank estimates that the extra cost to achieve the reduction goal will be $ 8.50 yearly per stunted child, for a total of $ 49.6 Billion for the next decade. Stunting has been shown to be one of the most cost-effective global health problems to invest in, with an estimated return on investment of $ 18 for every dollar spent thanks to its impact on economic productivity. Despite

2112-657: The decline for the past 15 years, but this decline has been too slow. As a comparison, there were 255 million stunted children in 1990, 224 in 1995, 198 in 2000, 182 in 2005, 169 in 2010, and 156 in 2016. However, the decline of stunting is geographically uneven, and is unequal among different groups in society. A research paper published in January 2020, which mapped stunting, wasting and underweight in children in low- and middle-income countries, predicted that only five countries would meet global targets for reducing malnutrition by 2025 in all second administrative subdivisions. Over

2176-648: The developing world and lead to stunting will not be possible. Studies have looked at ranking the underlying determinants in terms of their potency in reducing child stunting and found in the order of potency: Three of these determinants should receive attention in particular: access to sanitation, and diversity of calorie sources from food supplies. A study by the Institute of Development Studies has stressed that: "The first two should be prioritized because they have strong impacts yet are farthest below their desired levels". The goal of UN agencies, governments and NGO

2240-405: The effect of micro-nutrient fortification, increased availability of key nutrients or increased energy density of complementary foods on stunting also show heterogeneous results. It is estimated that education interventions, if optimally designed and implemented, could reduce stunting by 0.6 z-scores while food-based interventions could reduce stunting by 0.5 z-scores, which is moderate compared to

2304-718: The evidence in favor of investing in the reduction of stunting, current investments are too low at about $ 2.9 billion per year, with $ 1.6 billion coming from Governments, $ 0.2 billion from donors, and $ 1.1 paid by individuals. In 2015, the United Nations and its member states agreed on a new sustainable development agenda to promote prosperity and reduce poverty, putting forward 17 Sustainable Development Goals (SDGs) to be achieved by 2030. SDG 2 aims to “End hunger, achieve food security and improved nutrition, and promote sustainable agriculture”. Sub-goal 2.2. aims to “by 2030 end all forms of malnutrition, including achieving by 2025

2368-431: The fetus to poor growth leading to intrauterine growth retardation, which is strongly associated with low birth weight and size. Women who are underweight or anemic during pregnancy, are more likely to have stunted children which perpetuates the inter-generational transmission of stunting. Children born with low birth-weight are more at risk of stunting. However, the effect of prenatal under-nutrition can be addressed during

2432-408: The first cause considered. Three main things are needed to reduce stunting: To prevent stunting, it is not just a matter of providing better nutrition but also access to clean water, improved sanitation (hygienic toilets ) and hand washing at critical times (summarized as " WASH "). Without provision of toilets, prevention of tropical intestinal diseases, which may affect almost all children in

2496-435: The first of such series, investigators define the importance of the 1000 day and identify child malnutrition as being responsible for one third of all child deaths worldwide. This finding is key in that it points at malnutrition as a key determinant of child mortality that is often overlooked. When a child dies of pneumonia, malaria or diarrhea (some of the causes of child mortality in the world), it may well be that malnutrition

2560-559: The focus of scientific interest. Recent works showed promise that intervention with egg may improve linear growth in children. Comprehensive intervention package containing eggs also found to be effective in improving linear growth in children. However, the effect of egg intervention may not persist for longer period. Therefore, intervention programs should consider egg intervention for a longer period with emphasis on overall diet quality and improvement of environmental conditions. Ensuring proper nutrition of pregnant and lactating mothers

2624-422: The global burden of stunting. In many publications, the causes for stunting are considered very similar if not the same as the causes for malnutrition in children . However, there are some that contradict this notion. Recent evidence stresses that stunting may not be taken as a synonym of malnutrition, but as the natural condition of human height in non-Westernized societies. Almost all stunting occurs within

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2688-449: The highest prevalence are Timor-Leste, Burundi, Niger and Madagascar where more than half of children under 5 years old are stunted. The 2020 edition of FAO 's Near East and North Africa − Regional Overview of Food Security and Nutrition found that in 2019 22.5 percent of children under the age of five were stunted, 9.2 percent were wasted, and 9.9 percent were overweight across several Arab and North African countries. As of 2015, it

2752-515: The how bad these practices were prior to interventions. The condition termed environmental enteropathy is proposed as an immediate causal factor of childhood stunting. This is an asymptomatic small intestinal disorder characterized by chronic gut inflammation, reduced absorptive surface area, and disruption of intestinal barrier function. This small bowel disorder is attributable to sustained exposure to intestinal pathogens caused by fecal contamination of food and water. Recent evidence confirmed

2816-687: The human potential that remains trapped in malnutrition. The "Scaling Up Nutrition Movement (SUN)" movement is the main network of governments, non-governmental and international organizations, donors, private companies and academic institutions working together in pursuit of improved global nutrition and a world without hunger and malnutrition. It was launched at the UN General Assembly of 2010 and it calls for country-led multi-sectoral strategies to address child malnutrition by scaling-up evidence-based interventions in both nutrition specific and sensitive areas. As of 2016, 50 countries have joined

2880-487: The increased number of growing children that fall into the trap of malnutrition, due to population growth in the region. This is also true in Oceania, unlike Asia and Latin America and the Caribbean where substantial absolute reductions in the number of stunted children have been observed (for example, Asia reduced its number of stunted children from 133 million to 88 million between 2000 and 2015). The reduction in stunting

2944-401: The individual child may be short simply because both parents carried genes for shortness and not because of inadequate nutrition. However, if substantially more than 5% of an identified child population have height for age that is less than the fifth percentile on the reference curve, then the population is said to have a higher-than-expected prevalence of stunting, and malnutrition is generally

3008-520: The individual is exposed to excessive or poor quality diets as an adult. This can lead to higher risk of developing other related non-communicable diseases such as hypertension , coronary heart disease , metabolic syndrome and stroke. At societal level, stunted individuals do not fulfill their physical and cognitive developmental potential and will not be able to contribute maximally to society. Stunting can therefore limit economic development and productivity, and it has been estimated that it can affect

3072-526: The individual may develop cataracts along with coarse hair and hair loss. The inhibition of EBP promotes oligodendrocyte formation, which may help remyelination and thus limit multiple sclerosis development. Isolation, replication and characterization of the EBP and EBP-like protein have been performed in yeast / E. Coli strains (which lack the EBP protein in nature) to study the high-affinity drug binding effects. This protein -related article

3136-414: The internationally agreed targets on stunting and wasting in children under five years of age, and address the nutritional needs of adolescent girls, pregnant and lactating women, and older persons”. The global community has recognized more and more the critical importance of stunting during the past decade. Investments to address it have increased but remain far from being sufficient to solve it and unleash

3200-526: The key role of the 1000 days (pregnancy and first two years of life). In Nepal, short maternal stature, low maternal education, poor access to health services and poverty are strong determinants for stunting. However, in Nepal, stunting has decreased from 57% in 2001 to 36% in 2016, with lower prevalence in urban than in rural settings. In the Philippines, one in three children below five years old

3264-445: The leading risk factors for stunting were fetal growth restriction (birth weight <10th centile) followed by unimproved sanitation and diarrhea. It was estimated that 22% of stunting cases were attributable to environmental factors while 14% were attributable to child nutrition. In addition, looking at trends from 1970 to 2012 for 116 countries, women’s education, gender equality and finally quantity and quality of foods available at

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3328-632: The likelihood of the next generation also being stunted. There may be a link between children's linear growth and household sanitation practices. The ingestion of high quantities of fecal bacteria by young children through putting soiled fingers or household items in the mouth leads to intestinal infections. This affect children's nutritional status by diminishing appetite, reducing nutrient absorption, and increasing nutrient losses. The diseases recurrent diarrhea and intestinal worm infections ( helminthiasis ) which are both linked to poor sanitation have been shown to contribute to child stunting. Research on

3392-500: The linear growth during early years of life. Growth stunting is identified by comparing measurements of children's heights to the World Health Organization 2006 growth reference population: children who fall below the fifth percentile of the reference population in height for age are defined as stunted, regardless of the reason. The lower than fifth percentile corresponds to less than two standard deviations of

3456-675: The most at risk of infections that lead to diarrhea. It is the time when they stop breast feeding (weaning process), begin to crawl, put things in their mouths and become exposed to fecal matter from open defecation and environmental enteropathies. Previous interventions to reduce stunting have shown modest effects. Multiple micro-nutrient supplementation shows only small benefits for linear growth and results from studies supplementing lipid based nutrient supplements (LNS) to children are inconclusive. Educational interventions to improve complementary feeding may achieve behavioral change but have no or small effects on growth. Further, studies on

3520-401: The period 2000–2015, Asia reduced its stunting prevalence from 38 to 24%, Africa from 38 to 32%, and Latin America and the Caribbean from 18 to 11%. This equates to a relative reduction of 36, 17 and 39% respectively, indicating that Asia and Latin America and the Caribbean have displayed much larger improvements than Africa, which needs to address this issue with much more effort if it is to win

3584-604: The persistence of significant inequalities. The challenges these countries face are particularly difficult as they require intervening on two levels on what has come to be called “double burden of malnutrition”. As an example, in India 30% of children under 5 years of age are stunted, and 20% are overweight. Neglecting these nutritional problems is not an option anymore if countries are to escape poverty traps and provide opportunities to their people to live fulfilling productive lives without stunting. Nutritional interventions such as dietary supplementation and nutritional education have

3648-594: The postnatal period through proper child feeding practices. Maternal under-nutrition increases the risk of stunting at 2 years age. Based on data from 19 birth cohorts from LMICs, 20% of stunting is attributed to being born small-for-gestational-age (SGA). Further, estimated stunting at 2 years attributed to fetal growth restriction and preterm birth in 2011 was 33% in all developing countries and 41% in South Asia. Restricted pre- and postnatal growth are in turn important determinants of short adult height, increasing

3712-404: The potential to decrease stunting. The 2012 World Health Assembly , with its 194 member states, convened to discuss global issues of maternal, infant and young child nutrition, and developed a plan with 6 targets for 2025. The first of such targets aims to reduce by 40% the number of children who are stunted in the world, by 2025. This would correspond to 100 million stunted children in 2025. At

3776-560: The prevalence of stunted growth. If the current trend continues, the prevalence would be 21% in 2025, while the target is 27%. Maternal undernutrition and increased pathogen load in the intestine are the major risk factors of stunting in Bangladeshi children. Daily supplementation with egg, cow milk, and micronutrient powder found to be effective in improving linear growth of children in a community-based trial in Bangladesh. After

3840-725: The prevention of stunting are: According to the World Health organisation if less than 20% of the population is affected by stunting, this is regarded as  "low prevalence" in terms of public health significance. Values of 40% or more are regarded as very high prevalence, and values in between as medium to high prevalence. UNICEF has estimated that: "Globally, more than one quarter (26 per cent) of children under 5 years of age were stunted in 2011 – roughly 165 million children worldwide." and "In sub-Saharan Africa, 40 per cent of children under 5 years of age are stunted; in South Asia, 39 per cent are stunted." The four countries with

3904-611: The title EBP . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=EBP&oldid=1218753626 " Category : Disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages EBP (gene) 10682 13595 ENSG00000147155 ENSMUSG00000031168 Q15125 P70245 NM_006579 NM_007898 NP_006570 NP_031924 Emopamil binding protein

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3968-414: The water and sanitation system, increased female schooling, scale-up of quality maternal and child health services, increased economic power at family level (including successful cash transfer programs), and improvements in food security throughout the country. Nearly one-third of the children under five years of age are stunted in Bangladesh and 9% are severely stunted. The country is on track in reducing

4032-482: Was estimated that there were 156 million stunted children under 5 in the world, 90% of them living in low and low-middle income countries. 56% of these were in Asia, and 37% in Africa. It is possible that some of these children concurrently had other forms of malnutrition, including wasting and stunting, and overweight and stunting. No statistics are currently available for these combined conditions. Stunting has been on

4096-717: Was led by the Government and the Prime Minister himself, and included non-governmental partners at both central, regional and community level. After the strategy was implemented, stunting went from 22.9% to 17.9% (2005–2010), with very significant improvements in rural areas where it had been more difficult to reduce stunting rates in the past. The State of Maharashtra in Central-Western India has been able to produce an impressive reduction in stunting rates in children under 2 years of age from 44% to 22.8% in

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