Misplaced Pages

#856143

19-497: EPCR may refer to: Endothelial protein C receptor , a protein encoded by the PROCR gene ePCR (electronic polymerase chain reaction), or in silico PCR , use of software tools to calculate PCR results European Professional Club Rugby , organises rugby union club championships Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with

38-484: A deep groove with a lipid inside. The bound lipid in EPCR is usually phosphatidylcholine or phosphatidylethanolamine, and it contributes to APC binding CD201 is expressed on the surface of endothelial cells, which form the inner lining of blood vessels. CD201 has also been identified as hematopoietic stem cell (HSC) marker. The main function of CD201 is to enhance the activation of protein C. The binding of APC to EPCR on

57-475: A recent study on emergency granulopoiesis, it has been observed that CD201 is highly expressed on lymphoid-biased HSCs under steady-state conditions. However, during emergency granulopoiesis, the loss of CD201 marked a transcriptional switch from a lymphoid to a myeloid identity in HSCs. These findings suggest that CD201 is involved in the regulation of the response to acute infection. As with many signaling molecules,

76-619: A role in the regulation of immune cell populations involved in the pathogenesis of RA. The importance of CD201 as a clinical marker has been demonstrated in another study where decreased patient serum levels of CD201 have been associated with vascular dysfunctions. This article incorporates text from the United States National Library of Medicine , which is in the public domain . United States National Library of Medicine Located in Bethesda, Maryland ,

95-558: Is a protein that in humans is encoded by the PROCR gene . PROCR has also recently been designated CD201 ( cluster of differentiation 201). EPCR is a transmembrane glycoprotein receptor that plays a crucial role in regulation of blood coagulation, inflammation, and vascular integrity. Its ability to enhance the anticoagulant activity of protein C, modulate inflammatory responses, and maintain endothelial barrier function highlights its importance in homeostasis maintanance. EPCR protein

114-490: Is an N-glycosylated type I membrane protein that enhances the activation of protein C. It belongs to the MHC class I / CD1 family of proteins, The structure of CD201 consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain of CD201 contains a high-affinity binding site for activated protein C (APC), a serine protease with anticoagulant properties. The binding site for APC resembles

133-669: The Household Products Database . These resources are accessible without charge on the internet. The United States National Library of Medicine Radiation Emergency Management System provides: Radiation Emergency Management System is produced by the United States Department of Health and Human Services , Office of the Assistant Secretary for Preparedness and Response, Office of Planning and Emergency Operations, in cooperation with

152-681: The National Library of Medicine , Division of Specialized Information Services, with subject matter experts from the National Cancer Institute , the Centers for Disease Control and Prevention , and many U.S. and international consultants. The Extramural Division provides grants to support research in medical information science and to support planning and development of computer and communications systems in medical institutions. Research, publications, and exhibitions on

171-743: The 1960s and 1.5 million references going back to the 1950s. The National Library of Medicine runs the National Center for Biotechnology Information , which houses biological databases (PubMed among them) that are freely accessible on the Internet through the Entrez search engine and Lister Hill National Center For Biomedical Communications . As the United States National Release Center for SNOMED CT , NLM provides SNOMED CT data and resources to licensees of

190-516: The NLM UMLS Metathesaurus. NLM maintains ClinicalTrials.gov registry for human interventional and observational studies. Additionally NLM runs ChemIDplus, which is a chemical database of over 400,000 chemicals complete with names, synonyms, and structures . It includes links to NLM and other databases and resources, including links to federal, state and international agencies. The Toxicology and Environmental Health Program

209-624: The NLM is an institute within the National Institutes of Health . Its collections include more than seven million books , journals , technical reports , manuscripts , microfilms , photographs , and images on medicine and related sciences, including some of the world's oldest and rarest works. The current acting director of the NLM is Stephen Sherry . The precursor of the National Library of Medicine, established in 1836,

SECTION 10

#1732773279857

228-665: The campus of the National Institutes of Health, in 1962. Directors from 1945 to present Since 1879, the National Library of Medicine has published the Index Medicus , a monthly guide to articles, in nearly five thousand selected journals. The last issue of Index Medicus was printed in December 2004, but this information is offered in the freely accessible PubMed , among the more than fifteen million MEDLINE journal article references and abstracts going back to

247-440: The context of their effect matters. It has been mentioned above that CD201 has anti-inflammatory properties during coagulation. However, in a rheumatoid arthritis (RA) murine model it has been shown that CD201 knock-out (KO) mice had 40% lower arthritis incidence and 50% less disease severity compared to wild-type (WT) mice. CD201 KO mice also had significantly fewer Th1/Th17 cells in synovial tissues, which implies that CD201 may play

266-515: The endothelial cell surface facilitates its anticoagulant activity by inhibiting factors Va and VIIIa. Apart from its anticoagulant role, CD201 also participates in an anti-inflammatory signaling. CD201 has been shown to affect the production of inflammatory cytokines upon binding a coagulation factor VIIa. CD201 is gaining recognition as a marker in patients with acute infections as well as in patients with vascular diseases. Recently, CD201 has been studied in relationship with rheumatoid arthritis. In

285-714: The history of medicine and the life sciences also are supported by the History of Medicine Division. In April 2008 the current exhibition Against the Odds: Making a Difference in Global Health was launched. National Center for Biotechnology Information is an intramural division within National Library of Medicine that creates public databases in molecular biology, conducts research in computational biology , develops software tools for analyzing molecular and genomic data, and disseminates biomedical information, all for

304-750: The title EPCR . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=EPCR&oldid=1128183937 " Category : Disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages Endothelial protein C receptor 1L8J , 1LQV , 3JTC , 4V3D , 4V3E 10544 19124 ENSG00000101000 ENSMUSG00000027611 Q9UNN8 Q64695 NM_006404 NM_011171 NP_006395 NP_035301 Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor)

323-535: Was established at the National Library of Medicine in 1967 and is charged with developing computer databases compiled from the medical literature and from the files of governmental and nongovernmental organizations. The program has implemented several information systems for chemical emergency response and public education, such as the Toxicology Data Network , TOXMAP , Tox Town , Wireless Information System for Emergency Responders , Toxmystery, and

342-602: Was stopped, following the assassination of President Abraham Lincoln . In 1956, the library collection was transferred from the control of the U.S. Department of Defense to the Public Health Service of the Department of Health, Education, and Welfare and renamed the National Library of Medicine, through the instrumentality of Frank Bradway Rogers , who was the director from 1956 to 1963. The library moved to its current quarters in Bethesda, Maryland , on

361-936: Was the Library of the Surgeon General's Office , a part of the office of the Surgeon General of the United States Army . The Armed Forces Institute of Pathology and its Medical Museum were founded in 1862 as the Army Medical Museum . Throughout their history the Library of the Surgeon General's Office and the Army Medical Museum often shared quarters. From 1866 to 1887, they were housed in Ford's Theatre after production there

#856143