20-534: (Redirected from F-3 ) For the Misplaced Pages F3 criterion for speedy deletion, see Misplaced Pages:Criteria for speedy deletion § F3 . [REDACTED] Look up F3 in Wiktionary, the free dictionary. F3 or F03 may refer to: Computing [ edit ] F3, a function key on a computer keyboard F3 (language) , the working name for JavaFX Script,
40-544: A 1921 Dutch single-engine high-winged monoplane aircraft Hinterhoeller F3 , a yacht design by Canadian boat builder Hinterhoeller Yachts MV Agusta F3 series , an Italian sports motorcycle Spyder F3, a model of the three-wheeled motorcycle BRP Can-Am Spyder Roadster Sydney Ferries' Parramatta River ferry services , known as the F3 Pacific Motorway (Sydney–Newcastle) , formerly Sydney–Newcastle Freeway and commonly known as F3 LNER Class F3 ,
60-436: A World War I German prototype escort fighter HMS Cossack (F03) , a 1937 British Royal Navy destroyer HMS F3 , a British F class submarine McDonnell F3H Demon (later F-3 Demon), a United States Navy carrier-based jet fighter Mk F3 155mm , French self-propelled gun RAF Tornado F3 , a British fighter USS F-3 (SS-22) , a United States Navy submarine A future Japanese fighter jet (F-3 or F-X) based on
80-443: A class of British steam locomotives Arts [ edit ] F3 (Fisz Emade jako Tworzywo Sztuczne album) F3 (manga) (F³: Frantic, Frustrated & Female), a hentai manga series F3 (film) , a 2022 Indian Telugu-language film by Anil Ravipudi, a sequel to F2 (2019) Other [ edit ] F3 (classification) , a wheelchair sport classification F3 (font format) , created by Folio, Inc F3 (gene) ,
100-489: A protein F3 isoprostane F3 Nation , a network of free peer-led workouts for men in the U.S. Form, fit and function , an engineering term relating to design processes Formula Three , a class of automobile racing Forsmark 3, a unit at Forsmark Nuclear Power Plant , Sweden Motorola Motofone F3 , a mobile phone Nikon F3 , an SLR camera Taito F3 System , a 1992 arcade system board A tornado intensity rating on
120-400: A scripting language Fat-Free Framework , a PHP web application framework Military [ edit ] Douglas F-3 Havoc , a photographic reconnaissance plane Douglas F3D Skyknight (later F-10 Skyknight), a Douglas twin engine, mid-wing jet fighter F 3 Malmslätt , a former Swedish Air Force unit Felixstowe F.3 , a 1917 British First World War flying boat Hannover F.3 ,
140-548: Is a protein present in subendothelial tissue and leukocytes which plays a major role in coagulation and, in humans, is encoded by F3 gene . Its role in the blood clotting is the initiation of thrombin formation from the zymogen prothrombin . Thromboplastin defines the cascade that leads to the activation of factor X —the tissue factor pathway. In doing so, it has replaced the previously named extrinsic pathway in order to eliminate ambiguity. The F3 gene encodes tissue factor also known as coagulation factor III, which
160-450: Is a cell surface glycoprotein . This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII . The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor
180-477: Is a potent initiator that is fully functional when expressed on cell surfaces. There are three distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. In addition to the membrane-bound tissue factor, soluble form of tissue factor was also found which results from alternatively spliced tissue factor mRNA transcripts, in which exon 5
200-406: Is absent and exon 4 is spliced directly to exon 6. Tissue factor (TF) is the cell surface receptor for the serine protease factor VIIa. The best known function of tissue factor is its role in blood coagulation . The complex of TF with factor VIIa catalyzes the conversion of the inactive protease factor X into the active protease factor Xa . Together with factor VIIa, tissue factor forms
220-455: Is expressed by cells which are normally not exposed to flowing blood, such as sub-endothelial cells (e.g. smooth muscle cells ) and cells surrounding blood vessels (e.g. fibroblasts ). This can change when the blood vessel is damaged by, for example, physical injury or rupture of atherosclerotic plaques . Exposure of TF-expressing cells during injury allows the complex formation of TF with factor VII. Factor VII and TF form an equimolar complex in
SECTION 10
#1732790741999240-464: The i3 conceptual jet fighter and Mitsubishi X-2 prototype Transportation [ edit ] BYD F3 , an automobile EMD F3 , a North American cab-style diesel locomotive introduced in 1945 F3 (Istanbul Metro) , a funicular railway line in Istanbul, Turkey F3 class , project name for the mega-cruise ship Norwegian Epic Faso Airways IATA airline designator Fokker F.III ,
260-452: The Fujita scale F 3 , a type of formant in speech science F3, an EEG electrode site according to the 10-20 system F3 Derby , association football rivalry between Central Coast Mariners and Newcastle Jets See also [ edit ] F2 (disambiguation) [REDACTED] Topics referred to by the same term This disambiguation page lists articles associated with
280-453: The cytokine receptor class II family . The members of this receptor family are activated by cytokines . Cytokines are small proteins that can influence the behavior of white blood cells . Binding of VIIa to TF has also been found to start signaling processes inside the cell. The signaling function of TF/VIIa plays a role in angiogenesis and apoptosis . Pro-inflammatory and pro-angiogenic responses are activated by TF/VIIa-mediated cleavage by
300-982: The Wikimedia System Administrators, please include the details below. Request from 172.68.168.226 via cp1108 cp1108, Varnish XID 247101971 Upstream caches: cp1108 int Error: 429, Too Many Requests at Thu, 28 Nov 2024 10:45:42 GMT F3 (gene) 1AHW , 1BOY , 1DAN , 1FAK , 1J9C , 1JPS , 1O5D , 1TFH , 1UJ3 , 1W0Y , 1W2K , 1WQV , 1WSS , 1WTG , 1WUN , 1WV7 , 1Z6J , 2A2Q , 2AEI , 2AER , 2B7D , 2B8O , 2C4F , 2CEF , 2CEH , 2CEZ , 2CFJ , 2EC9 , 2F9B , 2FIR , 2FLB , 2HFT , 2PUQ , 2ZP0 , 2ZWL , 2ZZU , 3ELA , 3TH2 , 3TH3 , 3TH4 , 4IBL , 4M7L , 4Z6A , 4ZMA , 4YLQ , 2FLR 2152 14066 ENSG00000117525 ENSMUSG00000028128 P13726 P20352 NM_001993 NM_001178096 NM_010171 NP_001171567 NP_001984 NP_034301 Tissue factor , also called platelet tissue factor or Coagulation factor III ,
320-410: The extrinsic pathway of coagulation. This is opposed to the intrinsic (amplification) pathway, which involves both activated factor IX and factor VIII . Both pathways lead to the activation of factor X (the common pathway), which combines with activated factor V in the presence of calcium and phospholipid to produce thrombin (thromboplastin activity). TF is related to a protein family known as
340-460: The presence of calcium ions, leading to the activation of factor VII on a membrane surface. The inner surface of the blood vessel consists of endothelial cells. Endothelial cells do not express TF except when they are exposed to inflammatory molecules such as tumor necrosis factor-alpha (TNF-alpha). Another cell type that expresses TF on the cell surface in inflammatory conditions is the monocyte (a white blood cell). Historically, thromboplastin
360-669: The protease-activated receptor 2 (PAR2). EphB2 and EphA2 of the Eph tyrosine kinase receptor (RTK) family can also be cleaved by TF/VIIa. Tissue factor belongs to the cytokine receptor protein superfamily and consists of three domains : Note that one of factor VIIa's domains, GLA domain , binds in the presence of calcium to negatively charged phospholipids , and this binding greatly enhances factor VIIa binding to tissue factor. Some cells release TF in response to blood vessel damage (see next paragraph) and some do only in response to inflammatory mediators (endothelial cells/macrophages). TF
380-540: The same title formed as a letter–number combination. If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=F3&oldid=1173153351 " Category : Letter–number combination disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages F3">F3 Too Many Requests If you report this error to
400-403: Was a lab reagent, usually derived from placental sources, used to assay prothrombin times (PT time). Thromboplastin, by itself, could activate the extrinsic coagulation pathway. When manipulated in the laboratory, a derivative could be created called partial thromboplastin, which was used to measure the intrinsic pathway. This test is called the aPTT , or activated partial thromboplastin time. It
#998001