Organothiophosphates or organophosphorothioates are a subclass of organophosphorus compounds and of thiophosphate compounds . They are the organic compounds that contain a phosphate group in which one or more oxygen atoms is substituted by sulfur. Many are used as pesticides , some have medical applications, and some are used as oil additives. They generally have the chemical formula (RO) 3 PS, [(RO) 2 P(S)O] , R(RO) 2 PS, etc.
4-406: Fonofos is an organothiophosphate insecticide primarily used on corn. It is highly toxic and listed as an extremely hazardous substance . At room temperature, fonofos has a clear-to-yellow color. It has a distinct Mercaptan odour. It is soluble in most common organic Solvents . It is available in multiple forms, including granular , microgranular , This article about an ester
8-562: Is a stub . You can help Misplaced Pages by expanding it . Organothiophosphate Oligonucleotide phosphorothioates (OPS) are modified oligonucleotides where one of the oxygen atoms in the phosphate moiety is replaced by sulfur. These compounds are the basis of antisense therapy , e.g., the drugs fomivirsen (Vitravene), oblimersen , alicaforsen , and mipomersen (Kynamro). Further examples of these include: Variants with P=S double bonds were developed as insecticides because of their reduced mammalian toxicity. The phosphorothioate P=S bond
12-399: Is converted to the toxic P=O bond in the target insect. Similar oxidative conversion in mammals is slower, conferring lower toxicity in mammals. Generally these compounds feature tetrahedral phosphorus(V) centers. Classically, thiophosphates would include a P=S double bond as illustrated by malathion. The terminology is used loosely and thiophosphates include P-S single bonds as illustrated by
16-465: The drug amifostine. P–S single bonds can be generated through a variety of approaches, starting from thiols, disulfides, sulfinic acids as sulfur sources and various P(III) and P(V) coupling partners. PS–C bonds can also be formed through many comparable approaches, usually by alkylating a free phosphorus-thioate anion or thioic acid. They are conceptually derived from the inorganic thiophosphates (PO 4− x S x ). In fact, many are prepared via
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