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79-540: There are 20 positions available in the starting gate for the Kentucky Derby. Starting in 2017, one of those spots is reserved for the winner of the separate Japan Road to the Kentucky Derby. If the winner of the Japan Road declines the offer, their position is offered to the next ranked Japanese horse. If none of the top four finishers accepts the offer, this position in the starting gate reverts to qualifiers on

158-501: A Euro/Mideast Road to the Kentucky Derby which is rebranded from the European Road to the Kentucky Derby used in previous seasons. This series will consist of races from England, Ireland, France, and Unites Arab Emirates. The UAE Derby , which previously was part of the main road, has been moved to this series. The UAE Derby will retain the same points allocation as the previous season. The Cardinal Stakes has been removed from

237-625: A healthy diet are also recommended. Supportive care in severe cases includes treatment to relieve symptoms , fluid therapy , oxygen support and prone positioning , and medications or devices to support other affected vital organs. More severe cases may need treatment in hospital. In those with low oxygen levels, use of the glucocorticoid dexamethasone is recommended to reduce mortality. Noninvasive ventilation and, ultimately, admission to an intensive care unit for mechanical ventilation may be required to support breathing. Extracorporeal membrane oxygenation (ECMO) has been used to address

316-627: A variant of concern (VoC) or a variant of interest (VoI). Many of these variants have shared the more infectious D614G . As of May 2023, the WHO had downgraded all variants of concern to previously circulating as these were no longer detected in new infections. Sub-lineages of the Omicron variant (BA.1 – BA.5) were considered separate VoCs by the WHO until they were downgraded in March 2023 as no longer widely circulating. As of 24 September 2024 ,

395-473: A "clear, practical and understandable path" to the first leg of horse racing's Triple Crown , according to the official website of Churchill Downs . A poll conducted by Churchill Downs prior to the changes showed 83% of respondents did not understand how horses became starters for the Kentucky Derby. The previous system was based on earnings from all graded stakes races , which essentially gave equal weight to earnings from juvenile races, sprints and even races on

474-748: A "wild card" round. The first leg includes minor prep races, usually Grade II, with a 50-20-10-5 scale. The second leg consists of the Super Six Prep races, each worth 100 points to the winner. They include such historic races as the Florida Derby (G1) at Gulfstream Park, the Santa Anita Derby (G1) at Santa Anita Park, the Arkansas Derby (G1) at Oaklawn Park, the Louisiana Derby (G2) at Fair Ground Race Course,

553-493: A comprehensive international study. Such deaths include deaths due to healthcare capacity constraints and priorities, as well as reluctance to seek care (to avoid possible infection). Further research may help distinguish the proportions directly caused by COVID-19 from those caused by indirect consequences of the pandemic. In May 2022, the WHO estimated the number of excess deaths by the end of 2021 to be 14.9 million compared to 5.4 million reported COVID-19 deaths, with

632-595: A large number of people". During the COVID-19 pandemic, as with other pandemics, the meaning of this term has been challenged. The end of a pandemic or other epidemic only rarely involves the total disappearance of a disease, and historically, much less attention has been given to defining the ends of epidemics than their beginnings. The ends of particular epidemics have been defined in a variety of ways, differing according to academic field, and differently based on location and social group. An epidemic's end can be considered

711-451: A median range of 0.24% to 1.49%. IFRs rise as a function of age (from 0.002% at age 10 and 0.01% at age 25, to 0.4% at age 55, 1.4% at age 65, 4.6% at age 75, and 15% at age 85). These rates vary by a factor of ≈10,000 across the age groups. For comparison, the IFR for middle-aged adults is two orders of magnitude higher than the annualised risk of a fatal automobile accident and much higher than

790-399: A points scale of 100-50-25-15-10, 50-25-15-10-5, Sunland Derby , and Lexington Stakes , fewer points will be offered if the starting field is too small. If exactly five horses participate in these races, points will be allocated at 75% of the value. If four or fewer horses participate in these races, then points will be allocated at 50% of the value. International road changes: There will be

869-416: A racetrack may offer a high purse to attract better fields so the race will be upgraded in future years. The grade level is assigned by looking at data that indicates quality of the field for the last five years. In order to achieve or maintain a Grade I, it is necessary to attract a competitive field over a number of years. For graded turf races, track conditions (normally excessive rain) may sometimes force

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948-824: A random sample have consistently found that total infections considerably exceed the reported case counts. Many countries, early on, had official policies to not test those with only mild symptoms. The strongest risk factors for severe illness are obesity, complications of diabetes , anxiety disorders, and the total number of conditions. During the start of the COVID-19 pandemic it was not clear whether young people were less likely to be infected, or less likely to develop symptoms and be tested. A retrospective cohort study in China found that children and adults were just as likely to be infected. Among more thorough studies, preliminary results from 9 April 2020 found that in Gangelt ,

1027-423: A similar method, leading to the development of the graded stakes system by TOBA in 1973. The first list of North American Graded Stakes was published in 1974. The original purpose of grading was to identify the most competitive races, which helps horsemen make comparisons of the relative quality of bloodstock for breeding and sales purposes. When the race-grading program was being set up for its 1973 introduction by

1106-461: A social phenomenon, not just a biological one. Time reported in March 2024 that expert opinions differ on whether or not COVID-19 is considered endemic or pandemic, and that the WHO continued to call the disease a pandemic on its website. During the initial outbreak in Wuhan , the virus and disease were commonly referred to as "coronavirus", "Wuhan coronavirus", "the coronavirus outbreak" and

1185-451: A test. Conversely, deaths of people who died from underlying conditions following a positive test may be included. Countries such as Belgium include deaths from suspected cases, including those without a test, thereby increasing counts. Official death counts have been claimed to underreport the actual death toll, because excess mortality (the number of deaths in a period compared to a long-term average) data show an increase in deaths that

1264-518: Is associated with COVID-19 and is reported in as many as 88% of cases. The disease is mainly transmitted via the respiratory route when people inhale droplets and small airborne particles (that form an aerosol ) that infected people exhale as they breathe, talk, cough, sneeze, or sing. Infected people are more likely to transmit COVID-19 when they are physically close to other non-infected individuals. However, infection can occur over longer distances, particularly indoors. SARS‑CoV‑2 belongs to

1343-611: Is discouraged altogether by the World Health Organization (WHO), due to limited evidence of its efficacy. The severity of COVID-19 varies. It may take a mild course with few or no symptoms, resembling other common upper respiratory diseases such as the common cold . In 3–4% of cases (7.4% for those over age 65) symptoms are severe enough to cause hospitalisation. Mild cases typically recover within two weeks, while those with severe or critical diseases may take three to six weeks to recover. Among those who have died,

1422-439: Is intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes coronavirus disease 2019 ( COVID-19 ). Prior to the COVID-19 pandemic, an established body of knowledge existed about the structure and function of coronaviruses causing diseases like severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). This knowledge accelerated

1501-490: Is not explained by COVID-19 deaths alone. Using such data, estimates of the true number of deaths from COVID-19 worldwide have included a range from 18.2 to 33.5 million (≈27.4 million) by 18 November 2023 by The Economist , as well as over 18.5 million by 1 April 2023 by the Institute for Health Metrics and Evaluation and ≈18.2 million (earlier) deaths between 1 January 2020, and 31 December 2021, by

1580-452: Is the ratio of deaths to diagnoses. This metric can be misleading because of the delay between symptom onset and death and because testing focuses on symptomatic individuals. Based on Johns Hopkins University statistics, the global CFR was 1.02 percent (6,881,955 deaths for 676,609,955 cases) as of 10 March 2023. The number varies by region and has generally declined over time. Several variants have been named by WHO and labelled as

1659-406: Is the seventh known coronavirus to infect people, after 229E , NL63 , OC43 , HKU1 , MERS-CoV , and the original SARS-CoV . The standard method of testing for presence of SARS-CoV-2 is a nucleic acid test , which detects the presence of viral RNA fragments. As these tests detect RNA but not infectious virus, its "ability to determine duration of infectivity of patients is limited." The test

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1738-614: Is typically done on respiratory samples obtained by a nasopharyngeal swab ; however, a nasal swab or sputum sample may also be used. The WHO has published several testing protocols for the disease. Preventive measures to reduce the chances of infection include getting vaccinated, staying at home or spending more time outdoors, avoiding crowded places, keeping distance from others, wearing a mask in public, ventilating indoor spaces, managing potential exposure durations, washing hands with soap and water often and for at least twenty seconds, practising good respiratory hygiene, and avoiding touching

1817-614: The Blue Grass Stakes (currently G2) at Keeneland Race Course and the Wood Memorial Stakes (currently G2) at Aqueduct Racetrack. There are two wild card races with points offered on a 20-8-4-2 basis. The series originally consisted of 36 races in 2013 and has since changed over the years to include 46 races with the addition of the Japan Road to the Kentucky Derby (beginning in 2017) and European Road to

1896-514: The Huanan Seafood Wholesale Market there, but it is possible that human-to-human transmission began earlier. Molecular clock analysis suggests that the first cases were likely to have been between October and November 2019. The scientific consensus is that the virus is most likely of a zoonotic origin, from bats or another closely related mammal. While other explanations such as speculations that SARS-CoV-2

1975-407: The Institute for Health Metrics and Evaluation estimating the true number of cases as of early 2022 to be in the billions. One measure that public health officials and policymakers have used to monitor the pandemic and guide decision-making is the test positivity rate ("percent positive"). According to Johns Hopkins in 2020, one benchmark for a "too high" per cent positive is 5%, which was used by

2054-695: The Kentucky Derby Championship Season. The 2024 road consisted of 36 races, 21 races for the Kentucky Derby Prep Season and 15 races for the Kentucky Derby Championship Season. For 2024, the main Road to the Kentucky Derby resembled the 2023 Road to the Kentucky Derby , originally intended to consist of 37 races (revised down to 36 races with the cancellation of the Sham Stakes ), with 22 races for

2133-410: The Kentucky Derby Prep Season and 15 races for the Kentucky Derby Championship Season with the following changes: The 2025 road consists of 36 races, 21 races for the Kentucky Derby Prep Season and 15 races for the Kentucky Derby Championship Season. Race changes: The Virginia Derby will be added to the championship season with a points scale of 50-25-15-10-5. Points changes: For races with

2212-621: The Kentucky Derby Prep Season and the Kentucky Derby Championship Series . The prep season consists of early races on dirt or synthetic surfaces over distances of at least one mile that typically are run between late September and late February. Points are awarded to the top 4 finishers in each race on a 10-4-2-1 scale, except for the Breeders' Cup Juvenile, which has been awarded points on a 20-8-4-2 scale since 2016. The championship season consists of two legs and

2291-602: The basic reproduction number (R 0 ) for COVID-19 in January 2020 were between 1.4 and 2.5, but a subsequent analysis claimed that it may be about 5.7 (with a 95 per cent confidence interval of 3.8 to 8.9). In December 2021, the number of cases continued to climb due to several factors, including new COVID-19 variants. As of that 28   December, 282,790,822 individuals worldwide had been confirmed as infected. As of 14 April 2022 , over 500 million cases were confirmed globally. Most cases are unconfirmed, with

2370-479: The coronavirus pandemic and COVID pandemic ), caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ), began with an outbreak of COVID-19 in Wuhan , China, in December 2019. It spread to other areas of Asia, and then worldwide in early 2020. The World Health Organization (WHO) declared the outbreak a public health emergency of international concern (PHEIC) on 30 January 2020, and assessed

2449-411: The horseshoe , designed to improve traction, be no longer than 2 millimeters. This was in response to studies by Susan Stover showing that such toe grabs substantially increase the risk of catastrophic racing injuries. Recently, racing officials have also banned the use of furosemide (Lasix) in all Black Type races, which include graded and listed stakes races. A newly established race may inherit

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2528-474: The variants of interest as specified by the World Health Organization are BA.2.86 and JN.1, and the variants under monitoring are JN.1.7, KP.2, KP.3, KP.3.1.1, JN.1.18, LB.1, and XEC. Symptoms of COVID-19 are variable, ranging from mild symptoms to severe illness. Common symptoms include headache, loss of smell and taste , nasal congestion and runny nose , cough, muscle pain , sore throat , fever, diarrhoea , and breathing difficulties . People with

2607-429: The "Wuhan coronavirus outbreak", with the disease sometimes called "Wuhan pneumonia ". In January 2020, the WHO recommended 2019-nCoV and 2019-nCoV acute respiratory disease as interim names for the virus and disease per 2015 international guidelines against using geographical locations (e.g. Wuhan, China), animal species, or groups of people in disease and virus names in part to prevent social stigma . WHO finalised

2686-763: The American Thoroughbred Owners and Breeders Association it was done so as to match the data formatting in use by the British system being Grade I, Grade II, Grade III. However, the advent of the Internet meant that format would eventually be mostly abandoned in favor of G1, G2, G3. Used by TOBA itself, and most significantly by Equibase Company LLC that is the official supplier of racing information and statistics to America's Best Racing , Breeders' Cup , Daily Racing Form , NTRA , The Jockey Club , TRA, TVG , and Xpressbet . A notable exception to

2765-649: The Derby by May 1, 2013, and an additional $ 25,000 to start. If a qualifying horse was not nominated in either January or March, it could be supplemented to the Derby for $ 200,000. The 2013 season consisted of 36 races (19 races for the Kentucky Derby Prep Season and 17 races for the Kentucky Derby Championship Season). The 2014 season consisted of 34 races (18 races for the Kentucky Derby Prep Season and 16 races for

2844-699: The Euro/Mideast road. Graded stakes race A graded stakes race is a thoroughbred horse race in the United States that meets the criteria of the American Graded Stakes Committee of the Thoroughbred Owners and Breeders Association (TOBA). A specific grade level (I, II, III or listed) is then assigned to the race, based on statistical analysis of the quality of the field in previous years, provided

2923-620: The Kentucky Derby (beginning in 2018) series. In addition to qualifying via the Road to the Kentucky Derby, various fees are required to start in the Derby: a nomination fee, an entry fee and a starter fee. For example, in 2013 horses born in 2010 were eligible and the nomination fee was $ 600 which was to be paid by January 26, 2013. If the January date was missed, a late nomination fee of $ 6,000 could be paid by March 23, 2013. In addition, owners with qualifying horses were required to pay $ 25,000 to enter

3002-425: The Kentucky Derby Championship Season). The 2015 season consisted of 35 races (19 races for the Kentucky Derby Prep Season and 16 races for the Kentucky Derby Championship Season). The 2016 season consisted of 35 races (19 races for the Kentucky Derby Prep Season and 16 races for the Kentucky Derby Championship Season). The 2017 season consisted of 37 races (19 races for the Kentucky Derby Prep Season, 16 races for

3081-702: The Kentucky Derby Championship Season, and 2 races for the Japan Road to the Kentucky Derby). The 2018 season consisted of 46 races (20 races for the Kentucky Derby Prep Season, 16 races for the Kentucky Derby Championship Season, 7 races for the European Road to the Kentucky Derby, and 3 races for the Japan Road to the Kentucky Derby). The 2019 season consisted of 46 races (35 races in North America and Dubai on

3160-607: The United States and Canada, a graded race can be dormant for one year without losing its grade. The following races have been downgraded from Grade I status since 2010: The Donn Handicap was discontinued after its 2016 edition; its Grade I status was transferred to the Pegasus World Cup , which held its first edition in 2017 The following races have been upgraded to Grade I status since 2010: COVID-19 pandemic The COVID-19 pandemic (also known as

3239-640: The WHO in the past. As of 10 March 2023, more than 6.88   million deaths had been attributed to COVID-19. The first confirmed death was in Wuhan on 9 January 2020. These numbers vary by region and over time, influenced by testing volume, healthcare system quality, treatment options, government response, time since the initial outbreak, and population characteristics, such as age, sex, and overall health. Multiple measures are used to quantify mortality. Official death counts typically include people who died after testing positive. Such counts exclude deaths without

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3318-419: The WHO, US, European Union, and Australia. On 12 November 2022, the WHO released its Global Vaccine Market Report. The report indicated that "inequitable distribution is not unique to COVID-19 vaccines"; countries that are not economically strong struggle to obtain vaccines. On 14 November 2022, the first inhalable vaccine was introduced, developed by Chinese biopharmaceutical company CanSino Biologics , in

3397-448: The broad family of viruses known as coronaviruses . It is a positive-sense single-stranded RNA (+ssRNA) virus, with a single linear RNA segment. Coronaviruses infect humans, other mammals, including livestock and companion animals, and avian species. Human coronaviruses are capable of causing illnesses ranging from the common cold to more severe diseases such as Middle East respiratory syndrome (MERS, fatality rate ≈34%). SARS-CoV-2

3476-648: The centre of a major infection cluster in Germany, 15 per cent of a population sample tested positive for antibodies . Screening for COVID-19 in pregnant women in New York City , and blood donors in the Netherlands, found rates of positive antibody tests that indicated more infections than reported. Seroprevalence -based estimates are conservative as some studies show that persons with mild symptoms do not have detectable antibodies. Initial estimates of

3555-441: The change in format being the three New York Racing Association tracks. Fasig-Tipto began including grading information in 1975, Keeneland Association in 1976, and Daily Racing Form in 1978. In 1998, Canada began to grade Canadian races independently. Listed stakes were first added as a level in 2013. The American Graded Stakes Committee grades only races that: In 2008, the committee began requiring that toe grabs on

3634-760: The city of Shanghai, China. For the first two years of the pandemic, no specific and effective treatment or cure was available. In 2021, the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) approved the oral antiviral protease inhibitor , Paxlovid (nirmatrelvir plus the HIV antiviral ritonavir ), to treat adult patients. FDA later gave it an EUA. Most cases of COVID-19 are mild. In these, supportive care includes medication such as paracetamol or NSAIDs to relieve symptoms (fever, body aches, cough), adequate intake of oral fluids and rest. Good personal hygiene and

3713-484: The cumulative number of infected individuals (including asymptomatic and undiagnosed infections and excluding vaccinated infected individuals). It is expressed in percentage points. Other studies refer to this metric as the infection fatality risk . In November 2020, a review article in Nature reported estimates of population-weighted IFRs for various countries, excluding deaths in elderly care facilities, and found

3792-441: The development of various vaccine platforms during early 2020. The initial focus of SARS-CoV-2 vaccines was on preventing symptomatic and severe illness. The COVID-19 vaccines are widely credited for their role in reducing the severity and death caused by COVID-19. As of March 2023, more than 5.5 billion people had received one or more doses (11.8 billion in total) in over 197 countries. The Oxford-AstraZeneca vaccine

3871-528: The event of a tie, those horses will divide equally the points they would have received jointly had one beaten the other. If an owner wants to run a filly in the Derby, she will have to earn points in the same races as the colts and geldings – points earned of the Road to the Kentucky Oaks are not transferable to the Derby. The Road to the Kentucky Derby point system was created in 2012 to establish

3950-513: The eyes, nose, or mouth with unwashed hands. Those diagnosed with COVID-19 or who believe they may be infected are advised by healthcare authorities to stay home except to get medical care, call ahead before visiting a healthcare provider, wear a face mask before entering the healthcare provider's office and when in any room or vehicle with another person, cover coughs and sneezes with a tissue, regularly wash hands with soap and water and avoid sharing personal household items. A COVID-19 vaccine

4029-474: The general public beginning in December 2020, made available through government and international programs such as COVAX , aiming to provide vaccine equity . Treatments include novel antiviral drugs and symptom control. Common mitigation measures during the public health emergency included travel restrictions , lockdowns , business restrictions and closures, workplace hazard controls , mask mandates , quarantines, testing systems, and contact tracing of

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4108-437: The graded status of a discontinued race if it is held at the same facility under essentially identical conditions as the discontinued race. For example, the inaugural running of the Pegasus World Cup in January 2017 was Grade I, inheriting the status of the discontinued Donn Handicap . There are four grade levels, from Listed at the bottom to Grade I at the top. The latter are higher-class races for bigger prizes for horses of

4187-665: The infected. The pandemic caused severe social and economic disruption around the world, including the largest global recession since the Great Depression . Widespread supply shortages , including food shortages , were caused by supply chain disruptions and panic buying . Reduced human activity led to an unprecedented temporary decrease in pollution . Educational institutions and public areas were partially or fully closed in many jurisdictions, and many events were cancelled or postponed during 2020 and 2021. Telework became much more common for white-collar workers as

4266-487: The issue of respiratory failure. Existing drugs such as hydroxychloroquine , lopinavir/ritonavir , and ivermectin are not recommended by US or European health authorities, as there is no good evidence they have any useful effect. The antiviral remdesivir is available in the US, Canada, Australia, and several other countries, with varying restrictions; however, it is not recommended for use with mechanical ventilation, and

4345-453: The list. Up to 24 horses may enter the race, with the bottom four point-earners listed as "also eligible". If any of the top 20 is scratched after entries are taken but before betting begins, the next ranked horse on the also eligible list will be eligible to run. If two or more horses have the same number of points, the tiebreaker to get into the Kentucky Derby will be earnings in non-restricted stakes races, whether or not they are graded . In

4424-545: The main Road, 7 races for the European Road and 4 races for the Japan Road to the Kentucky Derby). Originally, the 2020 season consisted of 46 races (35 races in North America and Dubai on the main Road, 7 races for the European Road and 4 races for the Japan Road), with only minor changes from 2019. However, the season was heavily disrupted by the COVID-19 pandemic , which caused the cancellation or rescheduling of most of

4503-411: The major prep races. The 2021 road consisted of 36 races, 20 races for the Kentucky Derby Prep Season and 16 races for the Kentucky Derby Championship Season. The 2022 road consisted of 37 races, 21 races for the Kentucky Derby Prep Season and 16 races for the Kentucky Derby Championship Season. The 2023 road consisted of 37 races, 21 races for the Kentucky Derby Prep Season and 16 races for

4582-576: The majority of the unreported 9.5 million deaths believed to be direct deaths due the virus, rather than indirect deaths. Some deaths were because people with other conditions could not access medical services . A December 2022 WHO study estimated excess deaths from the pandemic during 2020 and 2021, again concluding ≈14.8 million excess early deaths occurred, reaffirming and detailing their prior calculations from May as well as updating them, addressing criticisms. These numbers do not include measures like years of potential life lost and may make

4661-464: The number and grade of a horse's stakes wins during the year. In general, stakes race refers to the stake, or entry fee, owners must pay, which generally forms part of the prize money offered to the top finishers. Not all stakes races are eligible for grading. Notably, races that are restricted to horses bred in a specific state (e.g., the Tiznow Stakes for California-breds) or country (e.g.,

4740-495: The official names COVID-19 and SARS-CoV-2 on 11 February 2020. Tedros Adhanom Ghebreyesus explained: CO   for corona , VI   for virus , D   for disease and 19 for when the outbreak was first identified (31 December 2019). WHO additionally uses "the COVID-19 virus" and "the virus responsible for COVID-19" in public communications. WHO named variants of concern and variants of interest using Greek letters . The initial practice of naming them according to where

4819-427: The outbreak as having become a pandemic on 11 March. COVID-19 symptoms range from asymptomatic to deadly, but most commonly include fever, sore throat , nocturnal cough , and fatigue. Transmission of the virus is often through airborne particles . Mutations have produced many strains (variants) with varying degrees of infectivity and virulence . COVID-19 vaccines were developed rapidly and deployed to

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4898-407: The pandemic 2021's leading cause of death . The time between symptom onset and death ranges from   6 to 41 days, typically about 14 days. Mortality rates increase as a function of age. People at the greatest mortality risk are the elderly and those with underlying conditions. The infection fatality ratio (IFR) is the cumulative number of deaths attributed to the disease divided by

4977-495: The pandemic evolved. Misinformation circulated through social media and mass media , and political tensions intensified . The pandemic raised issues of racial and geographic discrimination , health equity , and the balance between public health imperatives and individual rights . The WHO ended the PHEIC for COVID-19 on 5 May 2023. The disease has continued to circulate, but as of 2024, experts were uncertain as to whether it

5056-415: The population's age structure and the age-specific pattern of infections. There have also been reviews that have compared the fatality rate of this pandemic with prior pandemics, such as MERS-CoV. For comparison the infection mortality rate of seasonal flu in the United States is 0.1%, which is 13 times lower than COVID-19. Another metric in assessing death rate is the case fatality ratio (CFR), which

5135-528: The race meets the minimum purse criteria for the grade in question. In Canada, a similar grading system is maintained by the Jockey Club of Canada . Graded stakes races are similar to Group races in Europe but the grading is more dynamic in North America. A high grading can also be used by racetracks to promote the race in question. When determining Eclipse Award winners, racing journalists will consider

5214-421: The race to be run on the main (dirt) track. If this happens, the race is automatically downgraded by one grade level for that running only. The Committee then reviews the race within five days and may restore the original grade. For example, a Grade I turf race that is switched to the dirt will be recorded as a Grade II race, unless the committee feels the quality of the race was sufficient to warrant Grade I. In

5293-586: The races that make up the Canadian Triple Crown , all restricted to Canadian-breds) are excluded, regardless of the purse or quality of field. Conversely, some races that are not technically stakes races (usually invitational races where entry fees are not required by the racetrack) may be eligible for grading if they meet the quality standards. European authorities implemented the Pattern race system in 1972 and requested that North America implement

5372-467: The regular Road to the Kentucky Derby. Starting in 2018, Churchill Downs developed a similar European Road to the Kentucky Derby. The remaining 18 spots in the starting gate (or up 20 if the European and Japanese offers are declined) are offered to the top finishers on the main Road to the Kentucky Derby. If one of those horses does not enter the Derby, their position is given to the next ranked horses on

5451-462: The risk of dying from seasonal influenza . In December 2020, a systematic review and meta-analysis estimated that population-weighted IFR was 0.5% to 1% in some countries (France, Netherlands, New Zealand, and Portugal), 1% to 2% in other countries (Australia, England, Lithuania, and Spain), and about 2.5% in Italy. This study reported that most of the differences reflected corresponding differences in

5530-477: The same age and sex). Furthermore, there are "conditions" races, in which horses carry weights that are set by conditions, such as having won a certain number of races, or races of a certain value. Finally, some graded stakes are " handicaps ", in which an official handicapper assigns weights to each horse in an attempt to equalize the competition. All Grade I races must have a purse of at least $ 300,000, but not all races with such high purses are Grade I. For example,

5609-402: The same age group (2, 3 or 3 and up) and may further be restricted by sex. The weight conditions of the races may vary provided they meet the committee's standards to ensure competitiveness. Many grade I races are " weight-for-age ", with weights adjusted only according to age and sex, and also there are "set weights" where all horses carry the same weight (usually applicable when all horses are of

5688-496: The same infection may have different symptoms, and their symptoms may change over time. Three common clusters of symptoms have been identified: one respiratory symptom cluster with cough, sputum , shortness of breath, and fever; a musculoskeletal symptom cluster with muscle and joint pain, headache, and fatigue; a cluster of digestive symptoms with abdominal pain, vomiting, and diarrhoea. In people without prior ear, nose, and throat disorders, loss of taste combined with loss of smell

5767-411: The time from symptom onset to death has ranged from two to eight weeks. Prolonged prothrombin time and elevated C-reactive protein levels on admission to the hospital are associated with severe course of COVID-19 and with a transfer to intensive care units (ICU). Between 5% and 50% of COVID-19 patients experience long COVID , a condition characterised by long-term consequences persisting after

5846-420: The turf as to the traditional Derby prep races. The new system completely disregards sprint races, and places heavy weight on later races, thus putting a premium on recent results. The points system has changed the way horses are prepared for the Derby, the composition of the field and how the race itself is run given the absence of pure sprinters to ensure a fast early pace. The series is divided into two phases,

5925-694: The typical convalescence period of the disease. The most commonly reported clinical presentations are fatigue and memory problems, as well as malaise , headaches, shortness of breath , loss of smell, muscle weakness , low fever and cognitive dysfunction . Many countries attempted to slow or stop the spread of COVID-19 by recommending, mandating or prohibiting behaviour changes, while others relied primarily on providing information. Measures ranged from public advisories to stringent lockdowns. Outbreak control strategies are divided into elimination and mitigation. Experts differentiate between elimination strategies (known as " zero-COVID ") that aim to completely stop

6004-543: The variants were identified (e.g. Delta began as the " Indian variant") is no longer common. A more systematic naming scheme reflects the variant's PANGO lineage (e.g., Omicron 's lineage is B.1.1.529) and is used for other variants. SARS-CoV-2 is a virus closely related to bat coronaviruses , pangolin coronaviruses, and SARS-CoV . The first known outbreak (the 2019–2020 COVID-19 outbreak in mainland China ) started in Wuhan , Hubei, China, in December 2019. Many early cases were linked to people who had visited

6083-443: Was accidentally released from a laboratory have been proposed, as of 2021 these were not supported by evidence. Official "case" counts refer to the number of people who have been tested for COVID-19 and whose test has been confirmed positive according to official protocols whether or not they experienced symptomatic disease. Due to the effect of sampling bias , studies which obtain a more accurate number by extrapolating from

6162-457: Was still a pandemic. Pandemics and their ends are not well-defined, and whether or not one has ended differs according to the definition used. As of 24 November 2024, COVID-19 has caused 7,075,455 confirmed deaths. The COVID-19 pandemic ranks as the fifth- deadliest pandemic or epidemic in history . In epidemiology , a pandemic is defined as "an epidemic occurring over a very wide area, crossing international boundaries, and usually affecting

6241-509: Was the most widely used. According to a June 2022 study, COVID-19 vaccines prevented an additional 14.4 million to 19.8 million deaths in 185 countries and territories from 8 December 2020 to 8 December 2021. On 8 November 2022, the first recombinant protein-based COVID-19 vaccine (Novavax's booster Nuvaxovid ) was authorised for use in adults in the United Kingdom. It has subsequently received endorsement/authorisation from

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