Half-life (symbol t ½ ) is the time required for a quantity (of substance) to reduce to half of its initial value. The term is commonly used in nuclear physics to describe how quickly unstable atoms undergo radioactive decay or how long stable atoms survive. The term is also used more generally to characterize any type of exponential (or, rarely, non-exponential ) decay. For example, the medical sciences refer to the biological half-life of drugs and other chemicals in the human body. The converse of half-life (in exponential growth) is doubling time .
28-454: Half-life is a mathematical and scientific description of exponential or gradual decay. Half-life , half life or halflife may also refer to: Half-life The original term, half-life period , dating to Ernest Rutherford 's discovery of the principle in 1907, was shortened to half-life in the early 1950s. Rutherford applied the principle of a radioactive element's half-life in studies of age determination of rocks by measuring
56-733: A first-order reaction is given by the following equation: [ A ] 0 / 2 = [ A ] 0 exp ( − k t 1 / 2 ) {\displaystyle [{\ce {A}}]_{0}/2=[{\ce {A}}]_{0}\exp(-kt_{1/2})} It can be solved for k t 1 / 2 = − ln ( [ A ] 0 / 2 [ A ] 0 ) = − ln 1 2 = ln 2 {\displaystyle kt_{1/2}=-\ln \left({\frac {[{\ce {A}}]_{0}/2}{[{\ce {A}}]_{0}}}\right)=-\ln {\frac {1}{2}}=\ln 2} For
84-407: A first-order reaction, the half-life of a reactant is independent of its initial concentration. Therefore, if the concentration of A at some arbitrary stage of the reaction is [A] , then it will have fallen to 1 / 2 [A] after a further interval of ln 2 k . {\displaystyle {\tfrac {\ln 2}{k}}.} Hence,
112-446: A human being is about 9 to 10 days, though this can be altered by behavior and other conditions. The biological half-life of caesium in human beings is between one and four months. The concept of a half-life has also been utilized for pesticides in plants , and certain authors maintain that pesticide risk and impact assessment models rely on and are sensitive to information describing dissipation from plants. In epidemiology ,
140-491: A series of a parameter d / q that one wishes to keep small for quick convergence. Taking 3 = 2 + 1 , for example, generates This is actually the third line in the following table of expansions of this type: Starting from the natural logarithm of q = 10 one might use these parameters: This is a table of recent records in calculating digits of ln 2 . As of December 2018, it has been calculated to more digits than any other natural logarithm of
168-417: A substance can be complex, due to factors including accumulation in tissues , active metabolites , and receptor interactions. While a radioactive isotope decays almost perfectly according to first order kinetics, where the rate constant is a fixed number, the elimination of a substance from a living organism usually follows more complex chemical kinetics. For example, the biological half-life of water in
196-500: A value of ln 2 , a scheme of computing the logarithms of other integers is to tabulate the logarithms of the prime numbers and in the next layer the logarithms of the composite numbers c based on their factorizations This employs In a third layer, the logarithms of rational numbers r = a / b are computed with ln( r ) = ln( a ) − ln( b ) , and logarithms of roots via ln √ c = 1 / n ln( c ) . The logarithm of 2
224-399: Is a half-life describing any exponential-decay process. For example: The term "half-life" is almost exclusively used for decay processes that are exponential (such as radioactive decay or the other examples above), or approximately exponential (such as biological half-life discussed below). In a decay process that is not even close to exponential, the half-life will change dramatically while
252-537: Is also given by the alternating harmonic series . The decimal value of the natural logarithm of 2 (sequence A002162 in the OEIS ) truncated at 30 decimal places is given by: The logarithm of 2 in other bases is obtained with the formula The common logarithm in particular is ( OEIS : A007524 ) The inverse of this number is the binary logarithm of 10: By the Lindemann–Weierstrass theorem ,
280-457: Is proportional to the square of the concentration. By integrating this rate, it can be shown that the concentration [A] of the reactant decreases following this formula: 1 [ A ] = k t + 1 [ A ] 0 {\displaystyle {\frac {1}{[{\ce {A}}]}}=kt+{\frac {1}{[{\ce {A}}]_{0}}}} We replace [A] for 1 / 2 [A] 0 in order to calculate
308-421: Is the time it takes for a substance (drug, radioactive nuclide, or other) to lose one-half of its pharmacologic, physiologic, or radiological activity. In a medical context, the half-life may also describe the time that it takes for the concentration of a substance in blood plasma to reach one-half of its steady-state value (the "plasma half-life"). The relationship between the biological and plasma half-lives of
SECTION 10
#1732765152848336-468: Is useful in the sense that the powers of 2 are rather densely distributed; finding powers 2 close to powers b of other numbers b is comparatively easy, and series representations of ln( b ) are found by coupling 2 to b with logarithmic conversions . If p = q + d with some small d , then p / q = 1 + d / q and therefore Selecting q = 2 represents ln p by ln 2 and
364-1191: The law of large numbers suggests that it is a very good approximation to say that half of the atoms remain after one half-life. Various simple exercises can demonstrate probabilistic decay, for example involving flipping coins or running a statistical computer program . An exponential decay can be described by any of the following four equivalent formulas: N ( t ) = N 0 ( 1 2 ) t t 1 / 2 N ( t ) = N 0 2 − t t 1 / 2 N ( t ) = N 0 e − t τ N ( t ) = N 0 e − λ t {\displaystyle {\begin{aligned}N(t)&=N_{0}\left({\frac {1}{2}}\right)^{\frac {t}{t_{1/2}}}\\N(t)&=N_{0}2^{-{\frac {t}{t_{1/2}}}}\\N(t)&=N_{0}e^{-{\frac {t}{\tau }}}\\N(t)&=N_{0}e^{-\lambda t}\end{aligned}}} where The three parameters t ½ , τ , and λ are directly related in
392-417: The probability of a radioactive atom decaying within its half-life is 50%. For example, the accompanying image is a simulation of many identical atoms undergoing radioactive decay. Note that after one half-life there are not exactly one-half of the atoms remaining, only approximately , because of the random variation in the process. Nevertheless, when there are many identical atoms decaying (right boxes),
420-417: The analogous formula is: 1 T 1 / 2 = 1 t 1 + 1 t 2 + 1 t 3 + ⋯ {\displaystyle {\frac {1}{T_{1/2}}}={\frac {1}{t_{1}}}+{\frac {1}{t_{2}}}+{\frac {1}{t_{3}}}+\cdots } For a proof of these formulas, see Exponential decay § Decay by two or more processes . There
448-419: The concept of half-life can refer to the length of time for the number of incident cases in a disease outbreak to drop by half, particularly if the dynamics of the outbreak can be modeled exponentially . Natural logarithm of 2 In mathematics , the natural logarithm of 2 is the unique real number argument such that the exponential function equals two. It appears regularly in various formulas and
476-418: The decay is happening. In this situation it is generally uncommon to talk about half-life in the first place, but sometimes people will describe the decay in terms of its "first half-life", "second half-life", etc., where the first half-life is defined as the time required for decay from the initial value to 50%, the second half-life is from 50% to 25%, and so on. A biological half-life or elimination half-life
504-429: The decay period of radium to lead-206 . Half-life is constant over the lifetime of an exponentially decaying quantity, and it is a characteristic unit for the exponential decay equation. The accompanying table shows the reduction of a quantity as a function of the number of half-lives elapsed. A half-life often describes the decay of discrete entities, such as radioactive atoms. In that case, it does not work to use
532-418: The definition that states "half-life is the time required for exactly half of the entities to decay". For example, if there is just one radioactive atom, and its half-life is one second, there will not be "half of an atom" left after one second. Instead, the half-life is defined in terms of probability : "Half-life is the time required for exactly half of the entities to decay on average ". In other words,
560-462: The following way: t 1 / 2 = ln ( 2 ) λ = τ ln ( 2 ) {\displaystyle t_{1/2}={\frac {\ln(2)}{\lambda }}=\tau \ln(2)} where ln(2) is the natural logarithm of 2 (approximately 0.693). In chemical kinetics , the value of the half-life depends on the reaction order : The rate of this kind of reaction does not depend on
588-403: The half-life of a first order reaction is given as the following: t 1 / 2 = ln 2 k {\displaystyle t_{1/2}={\frac {\ln 2}{k}}} The half-life of a first order reaction is independent of its initial concentration and depends solely on the reaction rate constant, k . In second order reactions, the rate of reaction
SECTION 20
#1732765152848616-602: The half-life of second order reactions depends on the initial concentration and rate constant . Some quantities decay by two exponential-decay processes simultaneously. In this case, the actual half-life T ½ can be related to the half-lives t 1 and t 2 that the quantity would have if each of the decay processes acted in isolation: 1 T 1 / 2 = 1 t 1 + 1 t 2 {\displaystyle {\frac {1}{T_{1/2}}}={\frac {1}{t_{1}}}+{\frac {1}{t_{2}}}} For three or more processes,
644-533: The half-life of the reactant A 1 [ A ] 0 / 2 = k t 1 / 2 + 1 [ A ] 0 {\displaystyle {\frac {1}{[{\ce {A}}]_{0}/2}}=kt_{1/2}+{\frac {1}{[{\ce {A}}]_{0}}}} and isolate the time of the half-life ( t ½ ): t 1 / 2 = 1 [ A ] 0 k {\displaystyle t_{1/2}={\frac {1}{[{\ce {A}}]_{0}k}}} This shows that
672-1269: The natural logarithm of any natural number other than 0 and 1 (more generally, of any positive algebraic number other than 1) is a transcendental number . It is also contained in the ring of algebraic periods . ( γ is the Euler–Mascheroni constant and ζ Riemann's zeta function .) (See more about Bailey–Borwein–Plouffe (BBP)-type representations .) Applying the three general series for natural logarithm to 2 directly gives: Applying them to 2 = 3 2 ⋅ 4 3 {\displaystyle \textstyle 2={\frac {3}{2}}\cdot {\frac {4}{3}}} gives: Applying them to 2 = ( 2 ) 2 {\displaystyle \textstyle 2=({\sqrt {2}})^{2}} gives: Applying them to 2 = ( 16 15 ) 7 ⋅ ( 81 80 ) 3 ⋅ ( 25 24 ) 5 {\displaystyle \textstyle 2={\left({\frac {16}{15}}\right)}^{7}\cdot {\left({\frac {81}{80}}\right)}^{3}\cdot {\left({\frac {25}{24}}\right)}^{5}} gives: The natural logarithm of 2 occurs frequently as
700-459: The reactant. Thus the concentration will decrease exponentially. [ A ] = [ A ] 0 exp ( − k t ) {\displaystyle [{\ce {A}}]=[{\ce {A}}]_{0}\exp(-kt)} as time progresses until it reaches zero, and the half-life will be constant, independent of concentration. The time t ½ for [A] to decrease from [A] 0 to 1 / 2 [A] 0 in
728-444: The result of integration. Some explicit formulas for it include: The Pierce expansion is OEIS : A091846 The Engel expansion is OEIS : A059180 The cotangent expansion is OEIS : A081785 The simple continued fraction expansion is OEIS : A016730 which yields rational approximations, the first few of which are 0, 1, 2/3, 7/10, 9/13 and 61/88. This generalized continued fraction : Given
756-575: The substrate concentration , [A] . Thus the concentration decreases linearly. [ A ] = [ A ] 0 − k t {\displaystyle [{\ce {A}}]=[{\ce {A}}]_{0}-kt} In order to find the half-life, we have to replace the concentration value for the initial concentration divided by 2: [ A ] 0 / 2 = [ A ] 0 − k t 1 / 2 {\displaystyle [{\ce {A}}]_{0}/2=[{\ce {A}}]_{0}-kt_{1/2}} and isolate
784-412: The time: t 1 / 2 = [ A ] 0 2 k {\displaystyle t_{1/2}={\frac {[{\ce {A}}]_{0}}{2k}}} This t ½ formula indicates that the half-life for a zero order reaction depends on the initial concentration and the rate constant. In first order reactions, the rate of reaction will be proportional to the concentration of
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