"7+3" in the context of chemotherapy is an acronym for a chemotherapy regimen that is most often used today (as of 2014) as first-line induction therapy (to induce remission ) in acute myelogenous leukemia , excluding the acute promyelocytic leukemia form, which is better treated with ATRA and/or arsenic trioxide and requires less chemotherapy (if requires it at all, which is not always the case).
13-658: IAC may refer to: Medicine [ edit ] IAC (chemotherapy) , a chemotherapy regimen Internal auditory canal Organizations [ edit ] IAC (company) , an American media company International Academy of Ceramics International Academy of Cytology , a scientific global NGO for cytopathologists and cytologists India Against Corruption Indigenous Advisory Council , an Australian government agency Industrial Assessment Center , an American training program and research program Instituto de Astrofísica de Canarias , an astrophysical research institute in
26-449: A landline , while in GSM -compliant mobile phone (cell phone) systems, only the symbol + before the country code may be used irrespective of where the telephone is used at that moment; the network operator provides the access codes automatically. The following is a non-exhaustive list of countries that optionally allow for carrier selection in addition to using the standard prefix listed in
39-528: A popular South Korean TV variety program (alternately abbreviated as "ISAC") Ineffective assistance of counsel , in US law Infrastructure as Code , a technique for managing computer hardware, as software. Interactive activation and competition networks , a kind of neural network Interapplication communication , in computing International access code , in telecommunications See also [ edit ] IACS (disambiguation) Topics referred to by
52-454: Is different from Wikidata All article disambiguation pages All disambiguation pages IAC (chemotherapy) The name "7+3" comes from the duration of chemotherapy course, which consists of 7 days of standard-dose cytarabine , and 3 days of an anthracycline antibiotic or an anthracenedione , most often daunorubicin (can be substituted for doxorubicin or idarubicin or mitoxantrone ). There were attempts to intensify
65-529: Is still sometimes used, especially in poor-risk AML patients. The addition of 6-thioguanine gave rise to the DAT regimen, and the addition of 6-mercaptopurine gave rise to the DAM regimen. International access code This is a list of international dialing prefixes used in various countries for direct dialing of international telephone calls . These prefixes are typically required only when dialling from
78-456: The "7+3" regimen in order to try to improve its efficacy. Attempts were made to prolong the course (cytarabine for 10 days instead of 7, or daunorubicin/idarubicin for 4–5 days instead of 3). On the other hand, there were attempts to minimize the toxicity of the regimen by reducing the dose or the duration of the course, but these attempts compromised the efficacy of the regimen. The addition of vinca alkaloids ( vincristine or vinblastine ) to
91-458: The "7+3" regimen is also of no benefit in AML. The addition of etoposide to the standard "7+3" regimen is sometimes of benefit in poor-risk patients (many of whom are primary refractory to standard "7+3" induction regimens). It gave rise to the so-called ADE (or DAE = DA + etoposide) induction regimen in AML. The ADE induction (unlike, say, combinations of 7+3 with vinca alkaloids or prednisolone)
104-487: The "7+3" regimen, which was quite popular in AML(ALL?) in old times (when the biology of AML and the differences between AML and ALL was poorly understood) proved to be harmful in AML, lowering the chance of the patient achieving remission. This is because vinca alkaloids are rapidly deactivated in myeloid cells by their enzyme myeloperoxidase . So the vinca alkaloids do much more damage to the lymphoid cell lines (including
117-837: The Canary Islands InterAcademy Council , global network of academies of science, engineering, and medicine Inter-African Committee on Traditional Practices Affecting the Health of Women and Children , a rights organization International Action Center , a leftist organization International Advisory Council , operates the International Teletraffic Congress International Aerobatic Club , an American sports governing body International Astronautical Congress Interstate Athletic Conference , an all-boys high school sports league in
130-857: The Indoor hockey at Africa Indy Autonomous Challenge , a 2021 race for autonomous cars at the Indianapolis Motor Speedway Other uses [ edit ] I'm a Celebrity...Get Me Out of Here! (British TV series) , in TV Shows Idle air controller , in an internal combustion engine Image of the absolute conic, in computer vision; see Camera resectioning Imperfect authentic cadence , in music Indigenous Aircraft Carrier , an Indian Navy designation for aircraft carriers built in India Idol Star Athletics Championships ,
143-458: The T-cell lines responsible for antileukemic immunity) than to the myeloid cell lines. Moreover, vinca alkaloids in the context of AML cause AML cells to undergo a cell cycle arrest in the phase that renders those cells less sensitive to cytarabine and anthracyclines. Addition of glucocorticoids (like prednisolone ) or methotrexate or alkylating drugs (like cyclophosphamide or melphalan ) to
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#1732772736498156-662: The Washington, D.C. area Interstate Aviation Committee , a civil aviation authority in the Commonwealth of Independent States Irish Air Corps , the aviation wing of the Irish Defense Forces Israeli-American Council , an American nonprofit umbrella organization Istituto per le Applicazioni del Calcolo Mauro Picone , an Italian applied mathematics research institute Sport [ edit ] Indoor Africa Cup ,
169-403: The same term [REDACTED] This disambiguation page lists articles associated with the title IAC . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=IAC&oldid=1224150064 " Category : Disambiguation pages Hidden categories: Short description
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