Misplaced Pages

#439560

13-978: IL-22 or IL 22 or IL22 may refer to: Interleukin 22 Illinois's 22nd congressional district , an obsolete district in the USA Illinois Route 22 , USA Ilyushin Il-22 , a Russian jet bomber aircraft prototype flown in 1947 Ilyushin Il-22 , the airborne command post version of the Russian turboprop airliner Ilyushin Il-18 See also [ edit ] [REDACTED] Search for "il22" , "il-22" , "i-l22" , "il2-2" , or "i-l-2-2" on Misplaced Pages. All pages with titles containing IL22 All pages with titles beginning with IL-22 All pages with titles containing IL-22 [REDACTED] Topics referred to by

26-507: A heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1 subunits. IL-22R is expressed on tissue cells, and it is absent on immune cells. Crystallization is possible if the N-linked glycosylation sites are removed in mutants of IL-22 bound with high-affinity cell-surface receptor sIL-22R1. The crystallographic asymmetric unit contained two IL-22-sIL-22R1 complexes. IL-22 is produced by several populations of immune cells at

39-679: A site of inflammation . Producers are αβ T-cell classes T h 1 , T h 22 and T h 17 along with γδ T cells , NKT , ILC3 , neutrophils and macrophages . IL-22 takes effect on non-hematopoietic cells – mainly stromal and epithelial cells . Effects involve stimulation of cell survival, proliferation and synthesis of antimicrobials including S100 , Reg3β, Reg3γ and defensins . IL-22 thus participates in both wound healing and in protection against microbes . IL-22 dysregulation takes part in pathogenesis of several autoimmune diseases like systemic lupus erythematosus , rheumatoid arthritis and psoriasis .   IL-22 biological activity

52-613: Is a type II cytokine receptor . The receptor is tetrameric , composed of 2 α and 2 β subunits. The α subunit (encoded in the Il10ra gene) is expressed on haematopoietic cells (such as T, B, NK, mast, and dendritic cells ) whilst the β subunit (encoded in the Il10rb gene ) is expressed ubiquitously. The α subunit is exclusive to interleukin-10 , however the β subunit is shared with other type II cytokine receptors such as IL-22R , IL-26R and INFλR. The IL-10R α subunit acts as

65-827: Is a member of a group of cytokines called the IL-10 family or IL-10 superfamily (including IL-19 , IL-20 , IL-24 , and IL-26 ), a class of potent mediators of cellular inflammatory responses. It shares use of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28A/B and IL-29. IL-22, signals through the interferon receptor-related proteins CRF2-4 and IL-22R. It forms cell surface complexes with IL-22R1 and IL-10R2 chains resulting in signal transduction through receptor, IL-10R2. The IL-22/IL-22R1/IL-10R2 complex activates intracellular kinases ( JAK1 , Tyk2 , and MAP kinases ) and transcription factors, especially STAT3 . It can induce IL-20 and IL-24 signaling when IL-22R1 pairs with IL-20R2. IL-22 production

78-467: Is different from Wikidata All article disambiguation pages All disambiguation pages Interleukin 22 50616 116849 ENSG00000127318 ENSMUSG00000090461 Q9GZX6 Q9JJY8 NM_020525 NM_054079 NP_065386 NP_473420 Interleukin-22 (IL-22) is a protein that in humans is encoded by the IL22 gene . IL-22 is an α-helical cytokine. IL-22 binds to

91-448: Is induced mainly through IL-23 receptor signalling. IL-23 is produced by dendritic cells after recognition of ligands by specific Toll-like receptors especially in combination with Dectin-1 and or NOD2 signalling. IL-1β stimulates IL-22 production too. On the other hand IL-22 binding protein is a soluble inhibitor which blocks receptor binding site of IL-22. Interleukin-10 receptor Interleukin-10 receptor (IL-10R)

104-460: Is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL-22 can contribute to immune disease through

117-408: The ligand binding site and may be upregulated in various cell types as necessary. The IL-10R β functions as the signaling subunit and is constitutively expressed in a majority of cell types. There is evidence that upon ligand binding at the α subunit, a conformational change occurs in the β subunit that allows it to additionally bind to IL-10 . This structure forms a heterotetramer that leads to

130-520: The mucosal layer. Murine studies of test subjects lacking functional receptors showed rapid onset of bowel inflammatory disorders. In human studies, the early onset of irritable bowel disease has been correlated with defects in the IL-10R subunits. Cases involving both the α and β subunits were identified, some possessing fully dysfunctional receptors, and others being incapable of accepting phosphorylation.   This membrane protein –related article

143-450: The same term This disambiguation page lists articles associated with the same title formed as a letter–number combination. If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=IL-22&oldid=1215677822 " Category : Letter–number combination disambiguation pages Hidden categories: Short description

SECTION 10

#1732790500440

156-475: The signaling complex activation of JAK1 and TYK2 kinases. JAK1 associates with the α subunit, and TYK2 with the β subunit where they then phosphorylate portions of the α subunit. This recruits STAT3 , which is additionally phosphorylated by JAK1 and TYK2 . STAT3 homodimerizes, moves to the cellular nucleus, and activates gene transcription. The Interleukin-10 receptor is implicated in regulation of gastro-intestinal immune response, primarily in

169-615: The stimulation of inflammatory responses, S100s and defensins . IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by the often co-expressed cytokine IL-17A Targets of this cytokine are mostly non-hematopoietic cells – epithelial and stromal cells of following tissues and organs: liver , lung , skin , thymus , pancreas , kidney , gastrointestinal tract , synovial tissues , heart , breast , eye and adipose tissue . IL-22

#439560