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64-401: The iGEM Competition is a flagship program of the iGEM Foundation - an independent, non-profit organization dedicated to the advancement of synthetic biology, education and competition, and the development of an open, collaborative, and cooperative community. Aside from the competition, iGEM has established many initiatives and programs to support the future growth of synthetic biology throughout

128-464: A 2009 listed American Water Landmark located roughly one mile west of Fresh Pond and surrounded by the town of Belmont. The second area is the larger Hobbs Brook and Stony Brook watersheds, which share borders with neighboring towns and cities including Lexington, Lincoln , Waltham and Weston . Cambridge has been called the "City of Squares", as most of its commercial districts are major street intersections known as squares . Each square acts as

192-475: A Fitchburg Line commuter rail stop. Lesley University's University Hall and Porter campus are in Porter Square. Inman Square is at the junction of Cambridge and Hampshire streets in mid-Cambridge. It is home to restaurants, bars, music venues, and boutiques. Victorian streetlights, benches, and bus stops were added to the streets in the 2000s, and a new city park was installed. Lechmere Square

256-462: A bronze medal and 12% were not awarded a medal. In each division, the best performance in a certain aspect of the competition is honored with special prizes . The special prizes include: 'Best Project' in the respective categories (app. 10 categories), 'Best Art & Design', 'Best Hardware', 'Best Measurement', 'Best Software', 'Best Human Practices', 'Best Model', 'Best New Part', 'Best Poster', 'Best Presentation', 'Best Wiki' and others depending on

320-473: A competition with five teams from various schools was held. In 2005, teams from outside the United States took part for the first time. Since then iGEM has continued to grow, with 130 teams entering in 2010. Randy Rettberg, an engineer who has worked for technology companies including Apple , Sun and BBN , is the founder and president of iGEM. Because of this increasing size, in the years 2011 - 2013

384-749: A giant jamboree so every team could participate in one conference in Cambridge unlike in previous years where only the regional finalists were brought to Cambridge. The iGEM Jamborees for 2020 and 2021 were held online, due to the COVID-19 pandemic . Starting in 2022, the event was redesigned and rebranded to the iGEM Grand Jamboree, held in the Paris Expo Porte de Versailles . Beyond just building biological systems, broader goals of iGEM include: iGEM's dual aspects of self-organization and imaginative manipulation of genetic material have demonstrated

448-545: A lab in 1982, in contrast to the hostility that caused the Genetic Institute, a Harvard spinoff, to abandon Somerville and Boston for Cambridge. The biotech and pharmaceutical industries have since thrived in Cambridge, which now includes headquarters for Biogen and Genzyme ; laboratories for Novartis , Teva , Takeda , Alnylam , Ironwood , Catabasis, Moderna Therapeutics , Editas Medicine ; support companies such as Cytel ; and many smaller companies. During

512-504: A large co-working space, is in Kendall Square at 1 Broadway. The Cambridge Center office complex is in Kendall Square, and not at the actual center of Cambridge. The "One Kendall Square" complex is nearby, but not actually in Kendall Square. Central Square is formed by the junction of Massachusetts Avenue, Prospect Street, and Western Avenue. Containing a variety of ethnic restaurants, it was economically depressed as recently as

576-646: A major transfer point to streetcars that also operated in a short tunnel —which is still a major bus terminal, although the area under the Square was reconfigured dramatically in the 1980s when the Red Line was extended. A short distance away from the square lies the Cambridge Common, while the neighborhood north of Harvard and east of Massachusetts Avenue is known as Baldwin, in honor of the first Black principal of Cambridge public schools, Maria L. Baldwin. It

640-478: A neighborhood center. Kendall Square , formed by the junction of Broadway, Main Street, and Third Street, has been called "the most innovative square mile on the planet", owing to its high concentration of entrepreneurial start-ups and quality of innovation which have emerged in the vicinity of the square since 2010. Technology Square is an office and laboratory building cluster in this neighborhood. Just over

704-704: A new way to arouse student interest in modern biology and to develop their independent learning skills. Freiburg Ionis-Paris Marburg Toulouse-INSA-UPS TUM Straubing UToronto WageningenUR BioBrick Too Many Requests If you report this error to the Wikimedia System Administrators, please include the details below. Request from 172.68.168.226 via cp1108 cp1108, Varnish XID 220994880 Upstream caches: cp1108 int Error: 429, Too Many Requests at Thu, 28 Nov 2024 07:49:50 GMT Cambridge, Massachusetts Cambridge ( / ˈ k eɪ m b r ɪ dʒ / KAYM -brij )

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768-459: A women's liberal arts college, was based in Cambridge from its 1879 founding until its assimilation into Harvard in 1999. Kendall Square , near MIT in the eastern part of Cambridge, has been called "the most innovative square mile on the planet" due to the high concentration of startup companies that have emerged there since 2010. Founded in December 1630 during the colonial era , Cambridge

832-745: Is a city in Middlesex County, Massachusetts , United States. It is a suburb in the Greater Boston metropolitan area, located directly across the Charles River from Boston . The city's population as of the 2020 U.S. census was 118,403, making it the most populous city in the county, the fourth-largest in Massachusetts behind Boston , Worcester , and Springfield , and ninth-most populous in New England . The city

896-610: Is at the junction of Cambridge and First streets, adjacent to the CambridgeSide Galleria shopping mall. It is served by Lechmere station on the MBTA Green Line . The City of Cambridge officially recognizes 13 neighborhoods, which are as follows: In the Köppen-Geiger classification, Cambridge has a hot-summer humid continental climate (Dfa) with hot summers and cold winters, that can appear in

960-465: Is for example necessary to submit a new part to the Parts Registry , for a silver medal the team is required to document the functionality of a part and for a gold medal it is finally, among other criteria, necessary to obtain a proof-of-principle for the team's project. In 2016 as an example, 300 teams participated in the competition from which 37% received a gold medal, 25% a silver medal, 26%

1024-467: Is now within Harvard Square . The marketplace where farmers sold crops from surrounding towns at the edge of a salt marsh (since filled) remains within a small park at the corner of John F. Kennedy and Winthrop Streets. In 1636, Newe College, later renamed Harvard College after benefactor John Harvard , was founded as North America's first institution of higher learning . Its initial purpose

1088-483: Is south of Central Square, and bordered by MIT, the Charles River, Massachusetts Avenue, and River Street. Harvard Square is formed by the junction of Massachusetts Avenue, Brattle Street, Dunster Street, and JFK Street. This is the primary site of Harvard University and a major Cambridge shopping area. It is served by a Red Line station . Harvard Square was originally the Red Line's northwestern terminus and

1152-586: The Cambridge and Concord Turnpike (today's Broadway and Concord Ave.), the Middlesex Turnpike (Hampshire St. and Massachusetts Ave. northwest of Porter Square ), and what are today's Cambridge, Main, and Harvard Streets connected various areas of Cambridge to the bridges. In addition, the town was connected to the Boston & Maine Railroad , leading to the development of Porter Square as well as

1216-586: The Continental Army and appointed George Washington commander of it, Washington arrived at Cambridge Common to take command of the Patriot soldiers camped there. Many of these soldiers played a role in supporting Washington's successful Siege of Boston , which trapped garrisoned British troops from moving by land, forcing the British to ultimately abandon Boston. Cambridge Common is thus celebrated as

1280-589: The Fig Newton , Necco , Squirrel Brands , George Close Company (1861–1930s), Page & Shaw , Daggett Chocolate (1892–1960s, recipes bought by Necco), Fox Cross Company (1920–1980, originator of the Charleston Chew , and now part of Tootsie Roll Industries ), Kendall Confectionery Company, and James O. Welch (1927–1963, originator of Junior Mints , Sugar Daddies , Sugar Mamas , and Sugar Babies , now part of Tootsie Roll Industries). Main Street

1344-525: The Grand Prize Winner team, who are then awarded a big metal Lego -brick (see fig. below). The winning team may keep this challenge trophy for a year until it gets awarded to the next 'Grand Prize Winner'. Participants of a 'Grand Prize Winner' team are also given challenge coins of the respective year (see fig. below). iGEM developed out of student projects conducted during MIT's Independent Activities Periods in 2003 and 2004. Later in 2004,

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1408-479: The Great Depression and after World War II , Cambridge lost much of its industrial base. It also began to become an intellectual, rather than an industrial, center. Harvard University , which had always been important as both a landowner and an institution, began to play a more dominant role in the city's life and culture. When Radcliffe College was established in 1879, the town became a mecca for some of

1472-681: The Longfellow Bridge from Boston, at the eastern end of the MIT campus, it is served by the Kendall/MIT station on the MBTA Red Line subway. Most of Cambridge's large office towers are located in the Square. Kendall Square houses some of the biggest technological companies of the world, including Google , Microsoft , Amazon , Meta , and Apple . A biotech industry has developed in this area. The Cambridge Innovation Center ,

1536-647: The Massachusetts General Court purchased the land that became present-day Cambridge from the Naumkeag Squaw Sachem of Mistick . The town comprised a much larger area than the present city, with various outlying parts becoming independent towns over the years: Cambridge Village (later Newtown and now Newton ) in 1688, Cambridge Farms (now Lexington ) in 1712 or 1713, and Little or South Cambridge (now Brighton ) and Menotomy or West Cambridge (now Arlington ) in 1807. In

1600-629: The Cambridge Housing Authority and the Public Works Administration demolished an integrated low-income tenement neighborhood with African Americans and European immigrants. In its place, it built the whites-only " Newtowne Court " public housing development and the adjoining, blacks-only " Washington Elms " project in 1940; the city required segregation in its other public housing projects as well. As industry in New England began to decline during

1664-581: The birthplace of the Continental Army. The Massachusett inhabited the area that is now called Cambridge for thousands of years prior to European colonization of the Americas , most recently under the name Anmoughcawgen , which means 'fishing weir' or 'beaver dam' in Natick . At the time of European contact, the area was inhabited by Naumkeag or Pawtucket to the north and Massachusett to

1728-535: The bursting of the United States housing bubble in 2008 and 2009. Cambridge has been a sanctuary city since 1985 and reaffirmed its status as such in 2006. According to the U.S. Census Bureau , Cambridge has a total area of 7.1 square miles (18 km ), 6.4 square miles (17 km ) of which is land and 0.7 square miles (1.8 km ) (9.82%) of which is water. Cambridge is located in eastern Massachusetts, bordered by: The border between Cambridge and

1792-548: The carving up of the last estates into residential subdivisions to house the thousands of immigrants who arrived to work in the new industries. For much of the 19th and early 20th centuries, the city's largest employer was the New England Glass Company , founded in 1818. By the middle of the 19th century, it was the world's largest and most modern glassworks. In 1888, Edward Drummond Libbey moved all production to Toledo, Ohio , where it continues today under

1856-406: The city . Within four years of repealing the law, Cambridge, where "the city's form of rent control was unusually strict," saw new housing and construction increase by 50%, and the tax revenue from construction permits tripled. Property values in Cambridge increased by about $ 7.8 billion in the decade following the repeal. Roughly a quarter of this increase, $ 1.8 billion ($ 3 billion in 2024 dollars),

1920-477: The city. The population density was 16,354.9 inhabitants per square mile (6,314.7/km ). There were 47,291 housing units at an average density of 7,354.7 per square mile (2,839.7/km ). The racial makeup of the city was 66.60% White , 11.70% Black or African American , 0.20% Native American , 15.10% Asian (3.7% Chinese , 1.4% Asian Indian , 1.2% Korean , 1.0% Japanese ), 0.01% Pacific Islander , 2.10% from other races, and 4.30% from two or more races. 7.60% of

1984-681: The competition was split into three regions: Europe, the Americas, and Asia (though teams from Africa and Australia also entered via "Europe" and "Asia" respectively). Regional jamborees occurred during October; and some subset of teams attending those events were selected to advance to the World Championship at MIT in November. In January 2012 the iGEM Foundation was spun out of MIT as an independent non-profit organization located in Cambridge, Massachusetts , USA. The iGEM Foundation supports scientific research and education through operating

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2048-427: The competition year. Together with individual certificates, the teams are given glass trophies for each special prize (see fig. below). From all teams in a respective division, a number of finalists are selected (1 to 6, depending on year and division) and allowed to present their project again in front of all Jamboree participants. From the presented projects all judges select the winner of this year's iGEM competition,

2112-573: The construction of West Boston Bridge in 1792 connecting Cambridge directly to Boston , making it no longer necessary to travel eight miles (13 km) through the Boston Neck , Roxbury , and Brookline to cross the Charles River . A second bridge, the Canal Bridge, opened in 1809 alongside the new Middlesex Canal . The new bridges and roads made what were formerly estates and marshland into prime industrial and residential districts. In

2176-520: The creation of neighboring Somerville from the formerly rural parts of Charlestown . Cambridge was incorporated as a city in 1846. The city's commercial center began to shift from Harvard Square to Central Square, which became the city's downtown around that time. Between 1850 and 1900, Cambridge took on much of its present character, featuring streetcar suburban development along the turnpikes and working class and industrial neighborhoods focused on East Cambridge, comfortable middle-class housing on

2240-588: The era of rent control in Massachusetts , at least 20 percent of all rent controlled apartments in Cambridge housed the rich. The vast majority housed middle- and high-income earners. In an independent study conducted of 2/3 of the rent controlled apartments in Cambridge in 1988, 246 were households headed by doctors, 298 by lawyers, 265 by architects, 259 by professors, and 220 by engineers. There were 2,650 with students, including 1,503 with graduate students. Those who lived in rent controlled apartments included The end of rent control in 1994 had numerous effects on

2304-666: The first convenient Charles River crossing west of Boston , Newtowne was one of several towns, including Boston, Dorchester , Watertown , and Weymouth , founded by the 700 original Puritan colonists of the Massachusetts Bay Colony under Governor John Winthrop . Its first preacher was Thomas Hooker , who led many of its original inhabitants west in 1636 to found Hartford and the Connecticut Colony ; before leaving, they sold their plots to more recent immigrants from England. The original village site

2368-657: The first network router in 1969 and hosted the invention of computer-to-computer email in 1971. The 1980s brought a wave of high technology startups. Those selling advanced minicomputers were overtaken by the microcomputer . Cambridge-based VisiCorp made the first spreadsheet software for personal computers, VisiCalc , and helped propel the Apple II to consumer success. It was overtaken and purchased by Cambridge-based Lotus Development , maker of Lotus 1-2-3 (which was, in turn, replaced in by Microsoft Excel ). The city continues to be home to many startups. Kendall Square

2432-651: The force of Patriot soldiers camped on Cambridge Common on July 3, 1775, which is now considered the birthplace of the Continental Army . On January 24, 1776, Henry Knox arrived with an artillery train captured from Fort Ticonderoga , which allowed Washington to force the British Army to evacuate Boston . Most of the Loyalist estates in Cambridge were confiscated after the Revolutionary War . Between 1790 and 1840, Cambridge grew rapidly with

2496-638: The iGEM competition. The same year, iGEM expanded into having not only the Collegiate division, but also competitions for entrepreneurs and high school students. For their tenth anniversary, iGEM added new tracks to the existing ones: Art & Design, Community Labs, Entrepreneurship, Measurement, Microfluidics, Policy & Practice, and Software. Although Entrepreneurship and Software were tracks in previous years, in 2014 they were made more distinct in terms of their judging requirements. Furthermore, in 2014 iGEM did not have regional jamborees, but instead hosted

2560-619: The late 1990s; it underwent gentrification in recent years (in conjunction with the development of the nearby University Park at MIT ), and continues to grow more costly. It is served by the Central Station stop on the MBTA Red Line subway. Lafayette Square , formed by the junction of Massachusetts Avenue, Columbia Street, Sidney Street, and Main Street, is considered part of the Central Square area. Cambridgeport

2624-416: The late 19th century, various schemes for annexing Cambridge to Boston were pursued and rejected. Newtowne's ministers, Hooker and Shepard, the college's first president , the college's major benefactor, and the first schoolmaster Nathaniel Eaton were all Cambridge alumni, as was the colony's governor John Winthrop. In 1629, Winthrop had led the signing of the founding document of the city of Boston, which

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2688-421: The mid-19th century, Cambridge was the center of a literary revolution. It was home to some of the famous Fireside poets , named because their poems would often be read aloud by families in front of their evening fires. The Fireside poets, including Henry Wadsworth Longfellow , James Russell Lowell , and Oliver Wendell Holmes , were highly popular and influential in this era. Soon after, turnpikes were built:

2752-746: The name Owens-Illinois . The company's flint glassware with heavy lead content is prized by antique glass collectors, and the Toledo Museum of Art has a large collection. The Museum of Fine Arts in Boston and the Sandwich Glass Museum on Cape Cod also house several pieces. In 1895, Edwin Ginn , founder of Ginn and Company , built the Athenaeum Press Building for his publishing textbook empire. By 1920, Cambridge

2816-403: The nation's most academically talented female students. MIT 's move from Boston to Cambridge in 1916 reinforced Cambridge's status as an intellectual center of the United States. After the 1950s, the city's population began to decline slowly as families tended to be replaced by single people and young couples. In Cambridge Highlands, the technology company Bolt, Beranek, & Newman produced

2880-574: The neighboring city of Somerville passes through densely populated neighborhoods, which are connected by the MBTA Red Line . Some of the main squares, Inman , Porter, and to a lesser extent, Harvard and Lechmere , are very close to the city line, as are Somerville's Union and Davis Squares . Through the City of Cambridge's exclusive municipal water system, the city further controls two exclave areas, one being Payson Park Reservoir and Gatehouse,

2944-478: The old Cambridgeport, and Mid-Cambridge estates and upper-class enclaves near Harvard University and on the minor hills. The arrival of the railroad in North Cambridge and Northwest Cambridge led to three changes: the development of massive brickyards and brickworks between Massachusetts Avenue , Concord Avenue , and Alewife Brook ; the ice-cutting industry launched by Frederic Tudor on Fresh Pond ; and

3008-482: The population were Hispanic or Latino of any race (1.6% Puerto Rican , 1.4% Mexican , 0.6% Dominican , 0.5% Colombian & Salvadoran , 0.4% Spaniard ). Non-Hispanic Whites were 62.1% of the population in 2010, down from 89.7% in 1970. An individual resident of Cambridge is known as a Cantabrigian . In 2010, there were 44,032 households, out of which 16.9% had children under the age of 18 living with them, 28.9% were married couples living together, 8.4% had

3072-461: The south, and may have been inhabited by other groups such as the Totant, not well described in later European narratives. The contact period introduced a number of European infectious diseases which would decimate native populations in virgin soil epidemics , leaving the area uncontested upon the arrival of large groups of English settlers in 1630. In December 1630, the site of present-day Cambridge

3136-402: The southern end of New England's interior. Abundant rain falls on the city (and in the winter often as snow); it has no dry season. The average January temperature is 26.6 °F (−3 °C), making Cambridge part of Group D, independent of the isotherm. There are four well-defined seasons. As of the census of 2010, there were 105,162 people, 44,032 households, and 17,420 families residing in

3200-470: The summer, the teams add their new BioBricks to the Parts Registry and the scientific community can build upon the expanded set of BioBricks in the next year. At the annual ‘iGEM Jamboree ’ teams from all continents meet in Paris for a scientific expo event and conference where they present their projects to each other and to a scientific jury of ~400 judges. The judges award medals and special prizes to

3264-409: The summer, they use these parts and new parts of their own design to build biological systems and operate them in living cells. The teams are free to choose a project, which can build on previous projects or be new to iGEM. Successful projects produce cells that exhibit new and unusual properties by engineering sets of multiple genes together with mechanisms to regulate their expression. At the end of

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3328-412: The teams and select a ‘Grand Prize Winner’ team as well as ‘Runner-Up’ teams in each division (High School, Undergraduate and Overgraduate). Each participant receives a participating certificate (see fig. below) and has the possibility to earn medals (bronze, silver and gold; see fig. below) with their team depending on different criteria that the team fulfilled in the competitions. For a bronze medal it

3392-515: The town comprising farms and estates. Most inhabitants were descendants of the original Puritan colonists, but there was also a small elite of Anglican "worthies" who were not involved in village life, made their livings from estates, investments, and trade, and lived in mansions along "the Road to Watertown", present-day Brattle Street , which is still known as Tory Row . The Virginian George Washington , coming from Philadelphia , took command of

3456-517: The world: iGEM Community, iGEM Technology, iGEM Responsibility, iGEM Startups, and iGEM Leagues. Student teams are given a kit (so called ‘Distribution Kit’) of standard, interchangeable parts (so called ' BioBricks ') at the beginning of the summer from the Registry of Standard Biological Parts comprising various genetic components such as promoters , terminators , reporter elements , and plasmid backbones . Working at their local laboratories over

3520-489: Was a software hub through the dot-com boom and today hosts offices of such technology companies as Google, Microsoft , and Amazon . The Square also now houses the headquarters of Akamai . In 1976, Harvard's plans to start experiments with recombinant DNA led to a three-month moratorium and a citizen review panel. In the end, Cambridge decided to allow such experiments but passed safety regulations in 1977. This led to regulatory certainty and acceptance when Biogen opened

3584-482: Was chosen for settlement because it was safely upriver from Boston Harbor , making it easily defensible from attacks by enemy ships. The city was founded by Thomas Dudley , his daughter Anne Bradstreet , and his son-in-law Simon Bradstreet . The first houses were built in the spring of 1631. The settlement was initially referred to as "the newe towne". Official Massachusetts records show the name rendered as Newe Towne by 1632, and as Newtowne by 1638. Located at

3648-548: Was due to the repeal of rent control. Close to 40% of all Cambridge properties were under rent control when it was repealed. Their property values appreciated faster than non-rent controlled properties, as did the properties around them. By the end of the 20th century, Cambridge had one of the most costly housing markets in the Northeastern United States . Cambridge's mix of amenities and proximity to Boston kept housing prices relatively stable despite

3712-591: Was known as the Cambridge Agreement , after the university. In 1650, Governor Thomas Dudley signed the charter creating the corporation that still governs Harvard College. Cambridge grew slowly as an agricultural village eight miles (13 km) by road from Boston, the colony 's capital. By the American Revolution , most residents lived near the Common and Harvard College, with most of

3776-596: Was named in honor of the University of Cambridge in Cambridge , England, which was an important center of the Puritan theology that was embraced by the town's founders. Harvard University , an Ivy League university founded in Cambridge in 1636, is the oldest institution of higher learning in the United States. Massachusetts Institute of Technology (MIT), Lesley University , and Hult International Business School also are based in Cambridge. Radcliffe College ,

3840-743: Was nicknamed "Confectioner's Row". Only the Cambridge Brands subsidiary of Tootsie Roll Industries remains in town, still manufacturing Junior Mints in the old Welch factory on Main Street. The Blake and Knowles Steam Pump Company (1886), the Kendall Boiler and Tank Company (1880, now in Chelmsford, Massachusetts ), and the New England Glass Company (1818–1878) were among the industrial manufacturers in what are now Kendall Square and East Cambridge. In 1935,

3904-782: Was one among the first cities established in the Thirteen Colonies , and it went on to play a historic role during the American Revolution . In May 1775, approximately 16,000 American patriots assembled in Cambridge Common to begin organizing a military retaliation against British troops following the Battles of Lexington and Concord . On July 2, 1775, two weeks after the Second Continental Congress in Philadelphia formally established

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3968-633: Was one of New England 's main industrial cities, with nearly 120,000 residents. Among the largest businesses in Cambridge during the period of industrialization was Carter's Ink Company , whose neon sign long adorned the Charles River and which was for many years the world's largest ink manufacturer. Next door was the Athenaeum Press. Confectionery and snack manufacturers in the Cambridgeport-Area 4-Kendall corridor included Kennedy Biscuit Factory, later part of Nabisco and originator of

4032-479: Was renamed "Baldwin" in 2021, and so some know the area better by its former name, Agassiz, after the famed scientist Louis Agassiz . Porter Square is about a mile north on Massachusetts Avenue from Harvard Square, at the junction of Massachusetts and Somerville Avenues. It includes part of the city of Somerville and is served by the Porter Square Station , a complex housing a Red Line stop and

4096-480: Was training ministers . According to Cotton Mather , Newtowne was chosen for the site of the college by the Great and General Court , then the legislature of Massachusetts Bay Colony , primarily for its proximity to the popular and highly respected Puritan preacher Thomas Shepard . In May 1638, the settlement's name was changed to Cambridge in honor of the University of Cambridge in Cambridge , England. In 1639,

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