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85-691: There have been 56 men who served as Adjutant General in Indiana; 3 have served nonconsecutive terms, bringing the total number of terms to 59. The following have served as Adjutants General in Indiana: Mitch Daniels (2004) Mike Pence (2012) The following Adjutants General served in Indiana Territory : Mitch Daniels Mitchell Elias Daniels Jr. (born April 7, 1949) is an American academic administrator , businessman, author, and retired politician who served as

170-444: A Republican—if he had any" but Daniels had "nothing to do" with selling drugs. Another roommate said that police obtained a warrant to search the room based on the activity of the first roommate arrested. "Unbeknownst to [Daniels and the other current roommates] ... [he] was coming back there and using the room when we're not there and was involved with drugs much worse than pot...We considered ourselves innocent victims." Daniels refutes

255-490: A September 15, 2007, Wall Street Journal column, Daniels was quoted as saying about the Healthy Indiana Plan and cigarette tax increase saying, "A consumption tax on a product you'd just as soon have less of doesn't violate the rules I learned under Ronald Reagan ." Pharmaceutical A medication (also called medicament , medicine , pharmaceutical drug , medicinal drug or simply drug )

340-487: A chief political advisor and as a liaison to President Ronald Reagan in 1985. He then moved back to Indiana to become president of the Hudson Institute , a conservative think tank. He later joined Eli Lilly and Company where he served as president of North American Pharmaceutical Operations from 1993 to 1997 and as senior vice president of corporate strategy and policy from 1997 to 2001. In January 2001, Daniels

425-513: A common nuisance" for allowing the room to be used for the sale and use of drugs. In a plea agreement, the prosecutor dropped the charges in exchange for Daniels agreeing to pay a fine of $ 350 for using marijuana. Thirty-four years after the arrest, the first roommate detained (the individual arrested months before Daniels), told the Indianapolis Star that he was a partisan Democrat who "would gladly offer unflattering information about

510-431: A complicated economy, was needed to end constant confusion and bring Indiana into a year-long alignment with the rest of the country. Prior to the change, the counties in the western side of the state did not observe daylight saving time, although the counties in southeastern Indiana near Cincinnati , Ohio, did observe it unofficially due to being in that city's metropolitan area. Interests for both time zones had prevented

595-435: A critical role, often then selling the rights to larger companies that have the resources to run the clinical trials. Drug discovery is different from Drug Development. Drug Discovery is often considered the process of identifying new medicine. At the same time, Drug development is delivering a new drug molecule into clinical practice. In its broad definition, this encompasses all steps from the basic research process of finding

680-575: A group of 2245 elderly Americans (average age of 71) surveyed over the period 2010 – 2011, those percentages were 88%, 38%, and 64%. One of the key classifications is between traditional small molecule drugs; usually derived from chemical synthesis and biological medical products ; which include recombinant proteins , vaccines , blood products used therapeutically (such as IVIG ), gene therapy , and cell therapy (for instance, stem cell therapies). Pharmaceuticals or drugs or medicines are classified into various other groups besides their origin on

765-508: A job at the Indianapolis headquarters of the pharmaceutical company Pitman-Moore. The 10-year-old Daniels was accustomed to the mountains, and he at first disliked the flatland of central Indiana. He was still in grade school at the time of the move and first attended Delaware Trail Elementary, Westlane Junior High School, and North Central High School . In high school he was student body president . After graduation in 1967, Daniels

850-469: A libel suit for $ 20 million. A judge dismissed the case. Eli Lilly experienced dramatic growth during Daniels's tenure at the company. Prozac sales made up 30–40% of Lilly's income during the mid-to-late 1990s, and Lilly doubled its assets to $ 12.8 billion and doubled its revenue to $ 10 billion during the same period. When Daniels later became governor of Indiana, he drew heavily on his former Lilly colleagues to serve as advisers and agency managers. During

935-505: A list of essential medicines . A sampling of classes of medicine includes: Pharmaceuticals may also be described as "specialty", independent of other classifications, which is an ill-defined class of drugs that might be difficult to administer, require special handling during administration, require patient monitoring during and immediately after administration, have particular regulatory requirements restricting their use, and are generally expensive relative to other drugs. Drugs affecting

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1020-417: A one time payment of $ 3.85 billion and the commitment to make $ 4.4 billion worth of upgrades to the road. Most Democrats opposed the measure by starting an advertising campaign accusing Daniels of selling the road to foreign nations. Other critics characterized the deal for fundamentally changing the relationship between infrastructure and taxpayers" saying "the road intended to serve the people of Indiana now

1105-484: A part of a several months long drug investigation that began on Saturday, March 7, 1970, when one of Daniels's roommates was arrested for possessing "large quantities" of marijuana and other drugs. Two months later police raided the same residence hall, finding enough marijuana to fill two size 12 shoeboxes and arresting five additional individuals, including Daniels. Daniels and a roommate were charged with possession of marijuana, LSD and other drugs, along with "maintaining

1190-718: A pharmacist dispenses only on the order of a physician, physician assistant , or qualified nurse ) from over-the-counter drugs (those that consumers can order for themselves). Another key distinction is between traditional small molecule drugs, usually derived from chemical synthesis , and biopharmaceuticals , which include recombinant proteins , vaccines , blood products used therapeutically (such as IVIG ), gene therapy , monoclonal antibodies and cell therapy (for instance, stem cell therapies). Other ways to classify medicines are by mode of action, route of administration , biological system affected, or therapeutic effects . An elaborate and widely used classification system

1275-452: A process known as reverse pharmacology . Hits from these screens are then tested in cells and then in animals for efficacy . Even more recently, scientists have been able to understand the shape of biological molecules at the atomic level and to use that knowledge to design (see drug design ) drug candidates. Modern drug discovery involves the identification of screening hits, medicinal chemistry , and optimization of those hits to increase

1360-411: A process of identifying a new medicine. Development: Chemicals extracted from natural products are used to make pills, capsules, or syrups for oral use. Injections for direct infusion into the blood drops for eyes or ears. Preclinical research : Drugs go under laboratory or animal testing, to ensure that they can be used on Humans. Clinical testing: The drug is used on people to confirm that it

1445-560: A savings of $ 190 million, resulting in a budget of $ 23 billion. Annual spending growth for future budgets was cut to 2.8% from the 5.9% that had been standard for many years. Increase in revenues, coupled with the spending reductions, led to a $ 300 million budget surplus. Indiana is not permitted to take loans, as borrowing was prohibited in its constitution following the 1837 state bankruptcy . The state, therefore, had financed its deficit spending by reallocating $ 760 million in revenue that belonged to local government and school districts over

1530-533: A search committee, composed mostly of Purdue faculty and administrators recommended Daniels to become the university's 12th president after his term as governor ended on January 14, 2013. Ultimately, the hiring decision was made by the Trustees of the Board of Purdue University , all of whom Daniels appointed or re-appointed while Governor. He retired as Purdue president on January 1, 2023. Mitchell Elias Daniels Jr.

1615-445: A second term, defeating Jill Long Thompson . During his tenure, Daniels cut the state government workforce by 18%, cut and capped state property taxes, balanced the state budget through austerity measures and increasing spending by less than the inflation rate . In his second term, Daniels saw protest by labor unions and Democrats in the state legislature over Indiana's school voucher program, privatization of public highways, and

1700-404: A state take-over of a project initially started by the city of Indianapolis and led to a bitter feud between Daniels and the city leadership over who should have ownership of the project. The state ultimately won and took ownership of the facilities from the city. In 2006, Daniels continued his effort to reduce state operating costs by signing into law a bill privatizing the enrollment service for

1785-694: A stock sale leading to speculations of insider trading; and, because of his role at Eli Lilly, the high cost of prescription drugs. The 2004 election was the costliest in Indiana history, up until that time, with the candidates spending a combined US$ 23 million. Daniels won the election, garnering about 53% of the vote compared to Kernan's 45%. Kernan was the first incumbent governor to lose an election in Indiana since 1892. On his first day in office, Daniels created Indiana's first Office of Management and Budget to look for inefficiencies and cost savings throughout state government. The same day, he decertified all government employee unions by executive order , removing

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1870-402: A subsidy from the state. The plan promotes health screenings, early prevention services, and smoking cessation . It also provides tax credits for small businesses that create qualified wellness and Section 125 plans. The plan was paid for by an increase in the state's tax on cigarettes and the reallocation of federal Medicaid funds through a special waiver granted by the federal government. In

1955-499: A suitable molecular target to supporting the drug's commercial launch. Drug development is the process of bringing a new drug to the market once a lead compound has been identified through the process of drug discovery . It includes pre-clinical research (microorganisms/animals) and clinical trials (on humans) and may include the step of obtaining regulatory approval to market the drug. Drug Development Process Discovery: The Drug Development process starts with Discovery,

2040-598: A vein , or by drops put into the ear or eye . A medication that does not contain an active ingredient and is used in research studies is called a placebo . In Europe, the term is "medicinal product", and it is defined by EU law as: In the US, a "drug" is: Drug use among elderly Americans has been studied; in a group of 2,377 people with an average age of 71 surveyed between 2005 and 2006, 84% took at least one prescription drug, 44% took at least one over-the-counter (OTC) drug, and 52% took at least one dietary supplement ; in

2125-518: A win. In his many public stops, he frequently used the phrase "every garden needs weeding every sixteen years or so"; it had been 16 years since Indiana had had a Republican governor. His opponent in the general election was the incumbent , Joe Kernan , who had succeeded to the office upon the death of Frank O'Bannon . Campaign ads by Kernan and the Democratic Party attempted to tie Daniels to number of issues—his jail time for marijuana use;

2210-406: Is a drug used to diagnose , cure , treat, or prevent disease. Drug therapy ( pharmacotherapy ) is an important part of the medical field and relies on the science of pharmacology for continual advancement and on pharmacy for appropriate management. Drugs are classified in many ways. One of the key divisions is by level of control , which distinguishes prescription drugs (those that

2295-504: Is a medicine or a chemical compound used to treat or cure illness. According to Encyclopædia Britannica , medication is "a substance used in treating a disease or relieving pain ". As defined by the National Cancer Institute , dosage forms of medication can include tablets , capsules , liquids, creams , and patches. Medications can be administered in different ways, such as by mouth , by infusion into

2380-613: Is applied everywhere else in life," he said. Despite such efforts, during Daniels's 29-month tenure in the position, the projected federal budget surplus of $ 236 billion ballooned to a $ 400 billion deficit , due to the recession of 2001, tax cuts, the War in Afghanistan (2001–present) , and Iraq War . Nobel economics Laureate Paul Krugman noted Daniels is "held up as an icon of fiscal responsibility" without having earned it. Commenting on Daniels leadership he wrote "what I can't forget

2465-590: Is his key role in the squandering of the fiscal surplus Bush inherited. It wasn't just that he supported the Bush tax cuts; the excuses he made for that irresponsibility were stunningly fraudulent. So I just can't take his current pose of deficit hawkishness seriously." Following the September 11, 2001 attacks , Congress passed legislation authorizing the creation of the Department of Homeland Security . Just before

2550-485: Is safe to use. FDA Review: drug is sent to FDA before launching the drug into the market. FDA post-Market Review: The drug is reviewed and monitored by FDA for the safety once it is available to the public. The regulation of drugs varies by jurisdiction. In some countries, such as the United States, they are regulated at the national level by a single agency. In other jurisdictions, they are regulated at

2635-437: Is serving the profit needs of a multinational corporation". Daniels defended the lease, claiming that the road was not earning the state money because of the historical lack of political will to raise tolls. He told a congressional committee, "…instead of making money for the state, the road had operated at a loss for 5 of the previous 7 years…Political timidity had kept tolls locked at the same price since 1985…Even if we raised

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2720-523: Is still a lengthy, "expensive, difficult, and inefficient process" with a low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$ 1.8 billion. Drug discovery is done by pharmaceutical companies, sometimes with research assistance from universities. The "final product" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II, and III clinical trials, and most of them fail. Small companies have

2805-798: Is the Anatomical Therapeutic Chemical Classification System . The World Health Organization keeps a list of essential medicines . Drug discovery and drug development are complex and expensive endeavors undertaken by pharmaceutical companies , academic scientists, and governments. As a result of this complex path from discovery to commercialization, partnering has become a standard practice for advancing drug candidates through development pipelines. Governments generally regulate what drugs can be marketed, how drugs are marketed , and in some jurisdictions, drug pricing . Controversies have arisen over drug pricing and disposal of used Medicine . Medication

2890-406: Is used for euthanasia and physician-assisted suicide . Euthanasia is not permitted by law in many countries, and consequently, medicines will not be licensed for this use in those countries. A single drug may contain single or multiple active ingredients . The administration is the process by which a patient takes medicine. There are three major categories of drug administration: enteral (via

2975-469: Is used per day (e.g., four times a day). It may include event-related information (e.g., 1 hour before meals, in the morning, at bedtime), or complimentary to an interval, although equivalent expressions may have different implications (e.g., every 8 hours versus 3 times a day). In the fields of medicine, biotechnology , and pharmacology , drug discovery is the process by which new drugs are discovered. Historically, drugs were discovered by identifying

3060-512: The Hudson Institute , a conservative think tank . In 1988, Dan Quayle was elected Vice President of the United States , and Indiana governor Robert D. Orr offered to appoint Daniels to Quayle's vacant Senate seat. Daniels declined the offer, saying it would force him to spend too much time away from his family. While serving as the executive director of the Senate Republican campaign committee, Daniels expressed concern about

3145-506: The affinity , selectivity (to reduce the potential of side effects), efficacy/ potency , metabolic stability (to increase the half-life ), and oral bioavailability . Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials . One or more of these steps may, but not necessarily, involve computer-aided drug design . Despite advances in technology and understanding of biological systems, drug discovery

3230-3535: The central nervous system include psychedelics , hypnotics , anaesthetics , antipsychotics , eugeroics , antidepressants (including tricyclic antidepressants , monoamine oxidase inhibitors , lithium salts , and selective serotonin reuptake inhibitors (SSRIs)), antiemetics , anticonvulsants /antiepileptics, anxiolytics , barbiturates , movement disorder (e.g., Parkinson's disease ) drugs, nootropics , stimulants (including amphetamines ), benzodiazepines , cyclopyrrolones , dopamine antagonists , antihistamines , cholinergics , anticholinergics , emetics , cannabinoids , and 5-HT (serotonin) antagonists . The main classes of painkillers are NSAIDs , opioids , and local anesthetics . For consciousness (anesthetic drugs) Some anesthetics include benzodiazepines and barbiturates . The main categories of drugs for musculoskeletal disorders are: NSAIDs (including COX-2 selective inhibitors ), muscle relaxants , neuromuscular drugs , and anticholinesterases . Antibiotics , sympathomimetics , antihistamines , anticholinergics , NSAIDs , corticosteroids , antiseptics , local anesthetics , antifungals , and cerumenolytics. Bronchodilators , antitussives , mucolytics , decongestants , inhaled and systemic corticosteroids , beta2-adrenergic agonists , anticholinergics , mast cell stabilizers , leukotriene antagonists . Androgens , antiandrogens , estrogens , gonadotropin , corticosteroids , human growth hormone , insulin , antidiabetics ( sulfonylureas , biguanides / metformin , thiazolidinediones , insulin ), thyroid hormones , antithyroid drugs, calcitonin , diphosphonate , vasopressin analogues . Antifungal , alkalinizing agents , quinolones , antibiotics , cholinergics , anticholinergics , antispasmodics , 5-alpha reductase inhibitor , selective alpha-1 blockers , sildenafils , fertility medications . NSAIDs , anticholinergics , haemostatic drugs , antifibrinolytics , Hormone Replacement Therapy (HRT), bone regulators, beta-receptor agonists , follicle stimulating hormone , luteinising hormone , LHRH , gamolenic acid , gonadotropin release inhibitor , progestogen , dopamine agonists , oestrogen , prostaglandins , gonadorelin , clomiphene , tamoxifen , diethylstilbestrol . Emollients , anti-pruritics , antifungals , antiseptics , scabicides , pediculicides , tar products, vitamin A derivatives , vitamin D analogues , keratolytics , abrasives , systemic antibiotics , topical antibiotics , hormones , desloughing agents, exudate absorbents, fibrinolytics , proteolytics , sunscreens , antiperspirants , corticosteroids , immune modulators. Antibiotics , antifungals , antileprotics , antituberculous drugs , antimalarials , anthelmintics , amoebicides , antivirals , antiprotozoals , probiotics, prebiotics, antitoxins , and antivenoms. Vaccines , immunoglobulins , immunosuppressants , interferons , and monoclonal antibodies . Anti-allergics , antihistamines , NSAIDs , corticosteroids . Tonics, electrolytes and mineral preparations (including iron preparations and magnesium preparations ), parenteral nutrition , vitamins , anti-obesity drugs , anabolic drugs , haematopoietic drugs, food product drugs. Cytotoxic drugs , therapeutic antibodies , sex hormones , aromatase inhibitors , somatostatin inhibitors, recombinant interleukins , G-CSF , erythropoietin . Contrast media . A euthanaticum

3315-410: The human gastrointestinal tract ), injection into the body, and by other routes ( dermal , nasal , ophthalmic , otologic , and urogenital ). Oral administration , the most common form of enteral administration, can be performed using various dosage forms including tablets or capsules and liquid such as syrup or suspension. Other ways to take the medication include buccally (placed inside

3400-569: The requirement that state employees pay union dues by rescinding a mandate created by Governor Evan Bayh in a 1989 executive order . Dues-paying union membership subsequently dropped 90% among all state employees. In his first State of the State address on January 18, 2005, Daniels put forward his agenda to improve the state's fiscal situation. Indiana has a biennial budget, and had a projected two-year deficit of $ 800 million. Daniels called for strict controls on all spending increases and reducing

3485-580: The 49th governor of Indiana from 2005 to 2013. A Republican , he later served as president of Purdue University from 2013 until the end of 2022. Daniels began his career as an assistant to senator Richard Lugar , working as his chief of staff in the Senate from 1977 to 1982. He was appointed executive director of the National Republican Senatorial Committee when Lugar was chairman from 1983 to 1984. He worked as

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3570-568: The Hoosier Heartland Highway, I-69, and the Ohio River bridges. It also rehabilitated 1,400 bridges and 50% of the state's roads without using tax dollars or taking on new debt. As anticipated, drivers experienced dramatic hikes in tolls after the lease, which increased the cost to travel on the public road from $ 4.65 to $ 8.80 for passenger vehicles, and semitrailer trucks from $ 18 to $ 35.20. Despite doubling toll prices,

3655-810: The Reagan administration's response to the Supreme Court's ruling in Garcia v. San Antonio Metropolitan Transit Authority , regarding the Fair Labor Standards Act, and advocated limiting the power of the federal government in defining overtime rules for state and local governments, summing up his position by asking "What business is it of the Federal Government to tell localities how to structure their personnel practices?". In 1987, Daniels returned to Indiana as president and CEO of

3740-643: The active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules , natural products , or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology . Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compound libraries against isolated biological targets which are hypothesized to be disease-modifying in

3825-457: The administration was budgeting for both. The failure to provide long term cost estimates led opponents to claim that Daniels and the administration had suggested the entire war would cost less than $ 60 billion. The CBO has estimated the total cost of the war in Iraq to U.S. taxpayers will be around $ 1.9 trillion if it was carried on until 2017. Three months later, on March 25, 2003, five days after

3910-543: The annual growth rate of the budget. He also proposed a one-year 1% tax increase on all individuals and entities earning over $ 100,000. The taxing proposal was controversial and the Republican Speaker of the House, Brian Bosma , criticized Daniels and refused to allow the proposal to be debated. The General Assembly approved $ 250 million in spending cuts and Daniels renegotiated 30 different state contracts for

3995-410: The attempt to pass ' right to work ' legislation, leading to the 2011 Indiana legislative walkouts . During the legislature's last session under Daniels, he signed a ' right-to-work law ', with Indiana becoming the 23rd state in the nation to pass such legislation. It was widely speculated that Daniels would be a candidate in the 2012 presidential election , but he chose not to run. Shortly after,

4080-399: The basis of pharmacological properties like mode of action and their pharmacological action or activity, such as by chemical properties , mode or route of administration , biological system affected, or therapeutic effects . An elaborate and widely used classification system is the Anatomical Therapeutic Chemical Classification System (ATC system). The World Health Organization keeps

4165-597: The bill's passing and some have raised concerns over potential conflicts of interest. Congress repealed the thimerosal provision following expressions of public displeasure. Conservative columnist Ross Douthat stated in a column about Daniels's time at OMB that Daniels "carried water, as director of the Office of Management and Budget, for some of the Bush administration's more egregious budgets." But Douthat, while calling Daniels "America's Best Governor", defended Daniels against accusations that Daniels inaccurately assessed

4250-400: The cheek), sublingually (placed underneath the tongue), eye and ear drops (dropped into the eye or ear), and transdermally (applied to the skin). They can be administered in one dose, as a bolus . Administration frequencies are often abbreviated from Latin, such as every 8 hours reading Q8H from Quaque VIII Hora . The drug frequencies are often expressed as the number of times a drug

4335-563: The costs of the Iraq war. In 2002, Daniels helped discredit a report by Assistant to the President on Economic Policy Lawrence B. Lindsey estimating the cost of the Iraq War at between $ 100-$ 200 billion. Daniels called this estimate "very, very high" and stated that the costs would be between $ 50-$ 60 billion. At the time Daniels would not provide specific costs for either a long or a short military campaign against Saddam Hussein, saying

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4420-565: The course of many years. The funds were gradually and fully restored to the municipal governments using the surplus money, and the state reserve fund was grown to $ 1.3 billion. Two of Daniels's other tax proposals were approved: a tax on liquor and beverages to fund the construction of the Lucas Oil Stadium and a tax on rental cars to expand the Indiana Convention Center . The new source of funding resulted in

4505-505: The deal, including $ 150 million that went to Indiana's 92 counties for local roads, $ 240 million to seven counties for infrastructure and economic development projects, and $ 120 million for the Northwest Regional Development Authority for local economic development. Over the next ten years, Indiana would use the cash and interest from the deal to add or expand several major new roadways such as US 31,

4590-452: The director of O.M.B. is only concerned about numbers ... and he has no concern about what those numbers do or do not do for the country, for our military, for our security." Then HHS Secretary Tommy Thompson complained that Daniels's office would reject a proposal "nine times out of 10, just to show you who the boss is". The $ 2.13 trillion budget Daniels submitted to Congress in 2001 would have made deep cuts in many agencies to accommodate

4675-778: The director of the Office of Management and Budget . and was confirmed by the United States Senate by a vote of 100–0 on January 23, 2001. In this role he was also a member of the National Security Council and the Homeland Security Council . During his time as the director of the OMB, Daniels sought to restrict congressional spending, saying Congress's motto apparently is "Don't just stand there, spend something." During his tenure he

4760-541: The foreign-owned operator of the toll road filed for bankruptcy in 2014, and its $ 3.85 billion purchase price resulted in $ 6 billion in debts owed by the company to its financiers. Indiana retained the $ 3.85 billion lump sum payment and the lease was transferred to another Australian investment company without altering the terms of the lease. An October 2014 ITR report to the Indiana Toll Road Oversight Board cited numerous deficiencies along

4845-554: The highway including: deficient pavements and signage at travel plazas, activities at vehicle maintenance facilities that could allow petroleum products or other chemicals into open storm water drains, and closed sewage dump stations at risk of unmonitored dumping. In response, the new lease owners pledged to invest $ 260 million in capital improvements. In June 2015, Ken Daley, the new CEO of the Indiana Toll Road Concession Company, announced that all of

4930-835: The honesty of Illinois elections saying in 1984, "ballot integrity will be the single most decisive factor in the Illinois Senate race", a theme Daniels has returned to throughout his career. In 1990, Daniels left the Hudson Institute to accept a position at Eli Lilly and Company , the largest corporation headquartered in Indiana at that time. He was first promoted to President of North American Operations (1993–97) and then to Senior Vice President for Corporate Strategy and Policy (1997–2001). During his tenure Lilly pleaded guilty to two criminal misdemeanors, paid more than $ 2.7 billion in fines and damages, settled more than 32,000 personal injury claims—and copped to one of

5015-562: The idea that he was innocent saying he "had used marijuana" and "was fined for that, and that was appropriate". Daniels has disclosed the arrest on job applications and in government background checks and spoken about the incident in opinion columns. In a 1989 opinion piece in The Washington Post , Daniels called the incident the "unfortunate confluence of my wild oats period and America's libertine apogee" and said "On my college campus, just as on most college campuses, marijuana

5100-423: The largest state consumer protection cases involving a drug company in U.S. history. In 2009, Lilly also pleaded guilty for illegally marketing Zyprexa during Daniels' tenure and agreed to pay a $ 1.415 billion penalty that included a criminal fine of $ 515 million, the largest ever in a healthcare case and the largest criminal fine for an individual corporation ever imposed in a U.S. criminal prosecution of any kind at

5185-399: The legislation was signed by Bush, Republican lawmakers inserted language into the bill that authorized protection from liability corporations that manufactured thimerosal , a controversial vaccine preservative that has been the subject of multiple lawsuits. Eli Lilly was once the largest maker of thimerosal and is a major target of the lawsuits. Daniels was the budget director at the time of

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5270-612: The northwest and southwest corners that are in the Central Time Zone . In 2006 the legislature enacted Daniels' controversial plan to remake the state's highways system by leasing the Indiana Toll Road . Called the Major Moves, the road was leased to Statewide Mobility Partners, a joint venture company owned by Spanish firm Cintra and Australia's Macquarie Infrastructure Group for 75 years in exchange for

5355-602: The official adoption of daylight saving since the 1960s, leading to decades of debate . Daniels pressed for the entire state to switch to Central Time, but the General Assembly could not come to terms. Ultimately after a long debate, the General Assembly adopted Eastern Daylight Saving Time in April 2005. The measure passed by one vote and put most of the state on the Eastern Time Zone , except for counties in

5440-479: The original 1955 travel plazas would be demolished and replaced within the next five years. As of October 2015, the Booth Tarkington service area, the easternmost in Indiana, was permanently closed. In 2007, Daniels signed the Healthy Indiana Plan, which provided 132,000 uninsured Indiana workers with coverage. The program works by helping its beneficiaries purchase a private health insurance policy with

5525-481: The primary with 67% of the vote. While campaigning in the general election, Daniels visited all 92 counties at least three times. He traveled in a donated white RV nicknamed "RV-1" and covered with signatures of supporters and his campaign slogan, "My Man Mitch". "My Man Mitch" was a reference to a phrase once used by President George W. Bush to refer to Daniels. Bush campaigned with Daniels on two occasions, as Daniels hoped that Bush's popularity would help him secure

5610-504: The road was worth $ 2 billion at most and were surprised by the offer of nearly $ 4 billion in cash, plus that much in contracted improvements. Daniels called it the best deal since "Manhattan was sold for beads—except this time, the natives won." Initially, Daniels's support for the controversial legislation led to a rapid drop in his approval rating; in May 2005, a poll showed an 18-point drop in support and that only 42% of Hoosiers approved of

5695-618: The same period, Daniels also served on the board of directors of the Indianapolis Power & Light (IPL). He resigned from the IPL Board in 2001 to join the federal government, and sold his IPL stock along with all other holdings in order to comply with federal ethics requirements. Later that year the value declined when Virginia -based AES Corporation bought IPL. On December 22, 2000, President-elect George W. Bush announced that he would nominate Daniels to serve as

5780-415: The six-month supplemental appropriation as a request to fund the entire war. The costs of the Iraq war have exceeded $ 800 billion. Between September 2001 and October 2012, lawmakers appropriated about $ 1.4 trillion for operations in both the war in Iraq and Afghanistan. On May 7, 2003, Daniels announced that he would resign as OMB director within 30 days in a move that Bush administration officials said

5865-502: The start of the invasion, President Bush requested $ 53 billion through an emergency supplemental appropriation to cover operational expenses in Iraq until September 30 of that year. According to the Congressional Budget Office, Military operations in Iraq for 2003 cost $ 46 billion, less than the amount projected by Daniels and OMB. Douthat and other defenders of Daniels accuse Daniels's critics of mischaracterizing

5950-521: The state level, or at both state and national levels by various bodies, as is the case in Australia. The role of therapeutic goods regulation is designed mainly to protect the health and safety of the population. Regulation is aimed at ensuring the safety, quality, and efficacy of the therapeutic goods which are covered under the scope of the regulation. In most jurisdictions, therapeutic goods must be registered before they are allowed to be marketed. There

6035-410: The state's welfare programs. Indiana's welfare enrollment facilities were replaced with call centers operated by IBM . In mid-2009, after complaints of poor service, Daniels canceled the contract and returned the enrollment service to the public sector. One of the most controversial measures Daniels successfully pushed through was the state adoption of Daylight Saving Time , which Daniels argued, in

6120-511: The tax cuts being made, but few of the spending cuts were actually approved by Congress. Shortly after the invasion of Afghanistan , Daniels gave a speech to the National Press Club in which he challenged the view of those who wanted to continue typical spending while the nation was at war. "The idea of reallocating assets from less important to more important things, especially in a time of genuine emergency, makes common sense and

6205-452: The time. Daniels managed strategy to deflect attacks on Lilly's Prozac product by a public relations campaign against the drug being waged by the Church of Scientology . In one interview in 1992, Daniels said of the organization that "it is no church," and that people on Prozac were less likely to become victims of the organization. The Church of Scientology responded by suing Daniels in

6290-427: The tolls, there was little reason to believe that the governors who would come after me would have the inclination or the political ability to do the same. I once asked how much it cost to collect that 15-cent toll on the road and the answer came back at 34 cents. I joked that we would have been better off with the honor system and a fishbowl for occasional donations." Daniels and an independent accounting firm believed

6375-399: The way he was doing his job. In the following months, many of his reforms appeared to have a positive effect and his approval ratings rebounded. The income from the lease was used to finance a backlog of public transportation projects and create a $ 500 million trust fund to generate revenue for the maintenance of the highway system. Local governments also received a significant windfall from

6460-710: Was a member of the American Whig–Cliosophic Society , where he overlapped with future Supreme Court Justice Samuel Alito , who was a year below. He initially studied law at the Indiana McKinney School of Law in Indianapolis. After accepting a job with newly elected Senator Richard Lugar , he transferred to the Georgetown University Law Center , from which he earned a Juris Doctor . In 1970, while an undergraduate at Princeton, Daniels and three roommates were

6545-568: Was appointed by President George W. Bush as the director of the U.S. Office of Management and Budget , where he served until June 2003. Daniels ran in Indiana's 2004 gubernatorial election after leaving the Bush administration . He won the Republican primary with 67% of the vote and defeated Democratic incumbent Governor Joe Kernan in the general election. In 2008, Daniels was reelected to

6630-412: Was as easy to obtain as Budweiser beer and was viewed with equal complacency. For a time, I was a carefree consumer of both." Daniels claimed his "young Midwestern tail was jerked back into line" following the arrest. Daniels had his first experience in politics while still a teenager when, in 1968, he worked on the unsuccessful campaign of fellow Hoosier and Princeton alumnus William Ruckelshaus , who

6715-814: Was born on April 7, 1949, in Monongahela, Pennsylvania , the son of Dorothy Mae (née Wilkes) and Mitchell Elias Daniels. His father's parents were Syrian immigrants from Qalatiyah , Syria , of Antiochian Greek Orthodox descent. Daniels has been honored by the Arab-American Institute with the 2011 Najeeb Halaby Award for Public Service. His mother's ancestry was mostly English (where three of his great-grandparents were born). Daniels spent his early childhood years in Pennsylvania, Tennessee, and Georgia. The Daniels family moved to Indiana from Pennsylvania in 1959 when his father accepted

6800-622: Was criticized by Republicans and Democrats alike. After his first year in office Senator Ted Stevens , then the ranking member of the United States Senate Committee on Appropriations , suggested 'the best thing Daniels could do to repair relations with Congress was to go back to Indiana'. Representative Bill Young , then chairman of the United States House Committee on Appropriations complained about Daniels' leadership saying ''I'm convinced

6885-579: Was elected chairman of the National Republican Senatorial Committee , Daniels was appointed its executive director. Serving in that position (1983–84), he played a major role in keeping the GOP in control of the Senate. Daniels was also manager of three successful re-election campaigns for Lugar. In August 1985, Daniels became chief political advisor and liaison to state and local governments for President Ronald Reagan . As part of this position, Daniels led

6970-564: Was elected to the U.S. Senate in 1976, Daniels followed him to Washington, D.C. , as his Chief of Staff . Daniels served as Chief of Staff during Lugar's first term (1977–1982). During Daniel's time working with Senator Lugar, he met Cheri Herman, who was working for the National Park Service. The two married in 1978 and had four daughters. They divorced in 1993 and Cheri married again; Cheri later divorced her second husband and remarried Daniels in 1997. In 1983, when Lugar

7055-505: Was named one of Indiana's Presidential Scholars —the state's top male high school graduate that year—by President Lyndon B. Johnson . In 1971, Daniels earned a Bachelor's degree from the Woodrow Wilson School of Public and International Affairs at Princeton University after completing a senior thesis titled "The Politics of Metropolitanization: City-County Consolidation in Indianapolis, Indiana". While at Princeton, he

7140-629: Was running for the U.S. Senate against incumbent Democrat Birch Bayh . After the campaign, Daniels secured an internship in the office of then- Indianapolis mayor Richard Lugar , a Ruckelshaus ally. Daniels worked on Lugar's re-election campaign in 1971, and later, in 1974, he worked on Lugar's first campaign for Senate via L. Keith Bulen 's Campaign Communicators, Inc, a political consultancy where Daniels served as vice president. Daniels joined Lugar's mayoral staff in December 1974. Within three years, he became Lugar's principal assistant. After Lugar

7225-516: Was to prepare to run for governor of Indiana . Daniels's decision to run for Governor of Indiana led to most of the rest of Republican field of candidates dropping out of the race. The only challenger who did not do so was conservative activist and lobbyist Eric Miller. Miller worked for the Phoenix Group, a Christian rights defense group. Daniels's campaign platform centered on cutting the state budget and privatizing public agencies. He won

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