The two-pore-domain or tandem pore domain potassium channels are a family of 15 members that form what is known as leak channels which possess Goldman-Hodgkin-Katz (open) rectification . These channels are regulated by several mechanisms including signaling lipids , oxygen tension , pH , mechanical stretch , and G-proteins . Two-pore-domain potassium channels correspond structurally to a inward-rectifier potassium channel α-subunits. Each inward-rectifier potassium channel α-subunit is composed of two transmembrane α-helices, a pore helix and a potassium ion selectivity filter sequence and assembles into a tetramer forming the complete channel. The two-pore domain potassium channels instead are dimers where each subunit is essentially two α-subunits joined together.
3-676: K2P may refer to: Two-pore-domain potassium channel (K 2P ), a family of cell membrane leak channels Kimura's two parameter model (K2P model), a model of DNA evolution Centretown (postal code K2P ), Ottawa, Ontario, Canada; see List of postal codes of Canada: K See also [ edit ] [REDACTED] Search for "k2p" , "k2-p" , "k-2p" , "k-2-p" , or "k2ps" on Misplaced Pages. All pages with titles containing k2p Dipotassium phosphate (K 2 HPO 4 ) 2KP (684 AM), ABC Mid North Coast, Port Macquarie, Mid North Coast, New South Wales, Australia;
6-529: A radio station KP2 KKP (disambiguation) KPP (disambiguation) KP (disambiguation) Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title K2P . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=K2P&oldid=1256408430 " Category : Disambiguation pages Hidden categories: Short description
9-488: Is different from Wikidata All article disambiguation pages All disambiguation pages Two-pore-domain potassium channel Each single channel does not have two pores; the name of the channel comes from the fact that each subunit has two P (pore) domains in its primary sequence. To quote Rang and Dale (2015), "The nomenclature is misleading, especially when they are incorrectly referred to as two-pore channels". A decrease in these leak channels activity
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