An online database is a database accessible from a local network or the Internet , as opposed to one that is stored locally on an individual computer or its attached storage (such as a CD). Online databases are hosted on websites, made available as software as a service products accessible via a web browser. They may be free or require payment, such as by a monthly subscription. Some have enhanced features such as collaborative editing and email notification.
8-413: MEROPS is an online database for peptidases (also known as proteases , proteinases and proteolytic enzymes ) and their inhibitors. The classification scheme for peptidases was published by Rawlings & Barrett in 1993, and that for protein inhibitors by Rawlings et al. in 2004. The most recent version, MEROPS 12.4, was released in late October 2021. The classification is based on similarities at
16-443: A unique identifier. The families of peptidases are constructed by comparisons of amino acid sequences. A family is assembled around a type example , the sequence of a well-characterized peptidase or inhibitor. All other sequences in the family must be related to the family type example, either directly or through a transitive relationship involving one or more sequences already shown to be family members. Typically, FastA or BlastP
24-406: Is included in a clan if the tertiary structure of a family member can be shown to be related to that of the clan type example. Typically, DALI is used to establish clan membership, with a z score of 6.00 standard deviation units or above considered to be statistically significant. For peptidases, other evidence to indicate that families are related when a tertiary structure is absent includes
32-461: Is used to establish sequence relationships, with an expect value of 0.001 or lower taken to be statistically significant . HMMER or psi-blast searches are used for adding sequences which are distantly related to a family. Each family is identified by a letter representing the catalytic type of the peptidases it contains followed by an arbitrary unique number. Some families are divided into subfamilies due to evidence of very ancient divergence within
40-502: The Internet so that all its departments or divisions can access and update it. Most database services offer web-based consoles, which the end user can use to provision and configure database instances. Many pirate databases (e.g. Z-Library ) are established by individuals or institutions. The Stop Online Piracy Act bill was proposed by Lamar Smith in order to combat online piracy. This article about an online database
48-428: The family. The divergence corresponds to more than 150 accepted point mutations per 100 amino acid residues. The similarity in three-dimensional structures supports the evidence that many of the families do share common ancestry with others. "Clan" is used to describe such a group of families. A clan is also assembled around a type example, this being the structure of a well-characterized peptidase or inhibitor. A family
56-435: The same order of catalytic residues in the sequences. Each family, clan, peptidase, and inhibitor has a unique identifier. Description and example of identifiers are shown in the table below. Online database A cloud database is a database that is run on and accessed via the Internet, rather than locally. So, rather than keep a customer information database at one location, a business may choose to have it hosted on
64-400: The tertiary and primary structural levels. Comparisons are restricted to that part of the sequence directly involved in the reaction, which in the case of a peptidase must include the active site , and for a protein inhibitor the reactive site. The classification is hierarchical: sequences are assembled into families, and families are assembled into clans. Each peptidase, family, and clan has
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